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https://www.readbyqxmd.com/read/29020339/can-viral-load-be-used-as-a-surrogate-marker-in-clinical-studies-of-cytomegalovirus-in-solid-organ-transplantation-a-systematic-review-and-meta-analysis
#1
Yoichiro Natori, Ali Alghamdi, Mahmood Tazari, Veronica Miller, Shahid Husain, Takashi Komatsu, Paul Griffiths, Per Ljungman, Ani Orchanian-Cheff, Deepali Kumar, Atul Humar
Symptomatic CMV disease has been the standard endpoint for clinical trials in organ transplant recipients. Viral load may be a more relevant endpoint due to low frequency of disease. We performed a meta-analysis and systematic review of the literature. We found several lines of evidence to support the validity of viral load as an appropriate surrogate end-point including 1)viral loads in CMV disease are significantly greater than in asymptomatic viremia (OR 9.3, 95%CI 4.6 to 19.3); 2)kinetics of viral replication are strongly associated with progression to disease; 3)pooled incidence of CMV viremia and disease is significantly lower during prophylaxis compared with the full patient followup period (viremia incidence: 3...
September 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28989887/a-pragmatic-approach-to-the-indeterminate-thyroid-nodule
#2
REVIEW
Krishna G Seshadri
Thyroid nodules are prevalent in upto 68% of randomly selected individuals in whom high resolution ultrasound is performed. The majority of nodules are benign. The use of ultrasound coupled with FNAC has dramatically reduced the number of patients who undergo surgery for nodules. The six tier Bethesda scoring system has reduced variability and increased the ability to clinicians to guide patients with thyroid nodules. There is good correlation between cytology and histopathologic outcomes. A significant proportion of patients will however fall into an indeterminate category...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28988005/a-longitudinal-study-of-electronic-cigarette-use-and-onset-of-conventional-cigarette-smoking-and-marijuana-use-among-mexican-adolescents
#3
Paula Lozano, Inti Barrientos-Gutierrez, Edna Arillo-Santillan, Paola Morello, Raul Mejia, James D Sargent, James F Thrasher
PURPOSE: This study evaluated whether e-cigarette trial among Mexican adolescents increased the likelihood of trial and use of conventional cigarettes or marijuana use at follow-up. METHOD: A school-based longitudinal survey was conducted in 60 public middle schools from the three largest cities in Mexico. Students (12-13years old) were surveyed in 2015 and followed up 20 months later (n=6574). Generalized estimating equations models were used to evaluate the association between e-cigarette trial at baseline and conventional cigarettes smoking and marijuana use at follow-up...
September 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28982638/prospective-cohort-analyzing-risk-factors-for-chronic-kidney-disease-progression-in-children
#4
Vera M S Belangero, Liliane C Prates, Andreia Watanabe, Benita S G Schvartsman, Paula Nussenzveig, Natalia A Cruz, Ana L S Abreu, Isabel P Paz, Inalda Facincani, Fernanda E C Morgantetti, Andreia O Silva, Olberes V B Andrade, Maria F C Camargo, Paulo C Koch Nogueira
OBJECTIVE: To identify risk factors for chronic kidney disease (CKD) progression in Brazilian children and to evaluate the interactions between factors. METHODS: This was a multicenter prospective cohort in São Paulo, involving 209 children with CKD stages 3-4. The study outcome included: (a) death, (b) start of kidney replacement therapy, (c) eGFR decrease >50% during the followup. Thirteen risk factors were tested using univariate regression models, followed by multivariable Cox regression models...
October 2, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28972795/embolization-for-the-treatment-of-intractable-epistaxis-12-month-outcomes-in-a-two-centre-case-series
#5
Anthony E Robinson, William McAuliffe, Timothy J Phillips, Constantine C Phatouros, Tejinder P Singh
OBJECTIVE: Embolization is a treatment option for intractable epistaxis, however concerns regarding tissue necrosis, stroke and blindness persist in the literature. METHODS: A retrospective review of patients from September 2010 - January 2016 treated with embolization for epistaxis was performed. No patient was excluded. Followup was 12 months and no patient was lost. RESULTS: 62 embolizations on 59 patients occurred. 21 cases were taking anticoagulants, P2Y12 inhibiting agents or had a systemic coagulopathy...
October 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28971355/corr-insights-%C3%A2-high-survivorship-and-few-complications-with-cementless-total-wrist-arthroplasty-at-a-mean-followup-of-9-years
#6
L Kang
No abstract text is available yet for this article.
October 2, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28969403/the-impact-of-bladder-neck-sparing-on-urinary-continence-during-laparoscopic-radical-prostatectomy-results-from-a-high-volume-centre
#7
Ali Serdar Gozen, Yigit Akin, Mutlu Ates, Marcel Fiedler, Jens Rassweiler
OBJECTIVE: To evaluate the effects of bladder neck reconstruction techniques on early continence after laparoscopic radical prostatectomy (LRP). MATERIALS AND METHODS: This non-randomized retrospective study analyzed prospectively collected data concerning LRP. In total, 3107 patients underwent LRP between March 1999 and December 2016. Exclusion criteria were preoperative urinary incontinence, previous history of external beam radiotherapy, co-morbities which may affect urinary continence such as diabetes mellitus and/or neurogenic disorders, irregular followup, and follow-up shorter than 24 months...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28966390/erratum-management-guidelines-for-metal-on-metal-hip-resurfacing-arthroplasty-a-strategy-on-followup
#8
(no author information available yet)
[This corrects the article on p. 414 in vol. 51, PMID: 28790470.].
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28966383/transportal-anterior-cruciate-ligament-reconstruction-with-quadrupled-hamstring-tendon-graft-a-prospective-outcome-study
#9
Chandan Kumar, Anil Kumar Gupta, Santosh Kumar Singh, Rohit Jain
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction has been one of the most commonly performed procedures throughout the world. Unsatisfactory outcome with conventional ACL reconstruction has been attributed to nonanatomic graft placement. Researchers have advised placing the graft in the native footprint of ACL to avoid nonanatomic graft placement. The goal of this study was to analyze the outcome of anatomic single bundle ACL reconstruction using transportal technique. MATERIALS AND METHODS: This was a prospective outcome study conducted on 85 consecutive patients of ACL reconstruction of which 62 patients met inclusion and exclusion criteria and were analyzed for final results...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28966371/comparison-of-outcomes-of-two-femoral-fixation-devices-in-hamstring-anterior-cruciate-ligament-reconstruction
#10
Miguel Angel Sánchez-Carrasco, Juan Francisco Abellán, Salima Qudsi-Sinclair, Guadalupe Ruiz-Merino, Francisco Javier Carrillo-Juliá, David Bo-Rueda
BACKGROUND: Tear of the anterior cruciate ligament (ACL) is a common ligamentous injury of the knee. Reconstruction of this ligament is often required to restore functional stability of the knee. Outcome of ACL reconstruction is significantly affected by how the graft is fixed to the bone. This study is to determine if there is a different clinical outcome after cortical versus cortical-cancellous suspension femoral fixation in hamstring based anterior cruciate ligament (ACL) reconstruction...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28966081/patterns-of-care-and-outcomes-of-proton-and-eye-plaque-brachytherapy-for-uveal-melanoma-review-of-the-national-cancer-database
#11
Alexander J Lin, Yuan J Rao, Sahaja Acharya, Julie Schwarz, Prabakar Kumar Rao, Perry Grigsby
PURPOSE: To examine national practice patterns and outcomes of eye plaque brachytherapy compared to proton external beam radiotherapy in the treatment of choroid melanoma. METHODS AND MATERIALS: Demographic and clinical data for 1224 patients with choroid melanoma treated with either brachytherapy or proton beam therapy from 2004 to 2013 were obtained from the National Cancer Database. Logistic regression and propensity score matching was used to create a 1:1 matched cohort...
September 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28964298/implementation-of-a-perioperative-surgical-home-protocol-for-pediatric-patients-presenting-for-adenoidectomy
#12
Vidya T Raman, Dmitry Tumin, Joshua Uffman, Arlyne K Thung, Candice Burrier, Kris R Jatana, Charles Elmaraghy, Joseph D Tobias
INTRODUCTION: The perioperative surgical home (PSH) is a patient-centered model designed to improve health, streamline the delivery of health care, and reduce the cost of care. Following the national introduction of PSH in 2014 by the ASA, adult hospitals have reported success with this model, with studies validating the benefits of PSH including reducing length of stay, lowering costs, and improving patient satisfaction. METHODS: Eligible patients, ranging in age from 16-35 months of age, were identified by the pre-admission testing (PAT) registered nurses (RNs) and faculty anesthesiologists upon review of the patient history...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28948491/acetabular-reconstruction-with-femoral-head-autograft-after-intraarticular-resection-of-periacetabular-tumors-is-durable-at-short-term-followup
#13
Xiaodong Tang, Wei Guo, Rongli Yang, Taiqiang Yan, Shun Tang, Dasen Li
BACKGROUND: Pelvic reconstruction after periacetabular tumor resection is technically difficult and characterized by a high complication rate. Although endoprosthetic replacement can result in immediate postoperative functional recovery, biologic reconstructions with autograft may provide an enhanced prognosis in patients with long-term survival; however, little has been published regarding this approach. We therefore wished to evaluate whether whole-bulk femoral head autograft that is not contaminated by tumor can be used to reconstruct segmental bone defects after intraarticular resection of periacetabular tumors...
September 25, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28945678/arthroscopic-versus-open-treatment-for-acute-septic-arthritis-of-the-knee-in-children
#14
Brenton Johns, Mark Loewenthal, Eric Ho, David Dewar
BACKGROUND: Acute septic arthritis of the knee in children may be treated by arthroscopic or open methods however paediatric data comparing these methods is limited regarding both short and long-term outcomes. This study aimed to compare outcomes following arthroscopic versus open surgery for acute paediatric septic knee arthritis. METHODS: Paediatric patients with acute knee septic arthritis treated at our institution from 1996 to 2016 were retrospectively assessed...
September 21, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28943128/patterns-of-care-and-impact-of-brachytherapy-boost-utilization-for-squamous-cell-carcinoma-of-the-base-of-tongue-in-a-large-national-cohort
#15
Anna Lee, Babak Givi, S Peter Wu, Moses M Tam, Naamit K Gerber, Kenneth S Hu, Peter Han, David Schreiber
PURPOSE: The National Cancer Data Base was analyzed to evaluate the patterns of care and impact of brachytherapy (BT) boost on overall survival (OS) for patients with squamous cell carcinoma of the base of tongue. METHODS AND MATERIALS: Patients with nonmetastatic squamous cell carcinoma of the base of tongue between 2004 and 2012 who received concurrent external beam radiation therapy (EBRT) and chemotherapy with or without BT boost in the definitive setting were queried...
September 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28940152/osteomyelitis-risk-in-patients-with-transfemoral-amputations-treated-with-osseointegration-prostheses
#16
Jonatan Tillander, Kerstin Hagberg, Örjan Berlin, Lars Hagberg, Rickard Brånemark
BACKGROUND: Percutaneous anchoring of femoral amputation prostheses using osseointegrating titanium implants has been in use for more than 25 years. The method offers considerable advantages in daily life compared with conventional socket prostheses, however long-term success might be jeopardized by implant-associated infection, especially osteomyelitis, but the long-term risk of this complication is unknown. QUESTIONS/PURPOSES: (1) To quantify the risk of osteomyelitis, (2) to characterize the clinical effect of osteomyelitis (including risk of implant extraction and impairments to function), and (3) to determine whether common patient factors (age, sex, body weight, diabetes, and implant component replacements) are associated with osteomyelitis in patients with transfemoral amputations treated with osseointegrated titanium implants...
September 22, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28933330/-short-term-results-of-surgical-treatment-of-patients-with-hallux-rigidus
#17
M Dygrýnová, M Uvízl, J Gallo
PURPOSE OF THE STUDY Hallux rigidus is common and degenerative arthritis of the first metatarsophalangeal joint. The aim of this study was to assess the results of cheilectomy and total joint replacement (TJR) in patients with hallux rigidus. Minimum duration of followup was 18 months. MATERIAL AND METHODS The study included fifty-nine patients who underwent surgery at our Department due to hallux rigidus between January 2013 and December 2014. Thirty-seven patients underwent cheilectomy and twenty-two patients had total joint arthroplasty using METIS®...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28923815/use-of-complementary-health-approaches-among-diverse-primary-care-patients-with-type-2-diabetes-and-association-with-cardiometabolic-outcomes-from-the-sf-bay-collaborative-research-network-sf-bay-crn
#18
Margaret A Handley, Judy Quan, Maria T Chao, Neda Ratanawongsa, Urmimala Sarkar, Sophia Emmons-Bell, Dean Schillinger
PURPOSE: To describe use of complementary health approaches (CHAs) among patients with type 2 diabetes, and independent associations between CHA use and Hemoglobin A1c (A1C) and lower-density lipoprotein (LDL) cholesterol. METHODS: Participants were enrolled onto the SMARTSteps Program, a diabetes self-management support program conducted between 2009 and 2013 in San Francisco. At the 6-month interview, CHA use in the prior 30 days was estimated using a 12-item validated instrument...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28895983/primary-headache-associated-with-sexual-activity-a-case-report
#19
Tuba Özcan, Esra Yancar Demir, Murat Doğan İşcanlı
Headaches provoked by triggering factors have been recognized for many decades. In many cases, the development of such headaches is secondary to an underlying pathology. However, in some cases, no abnormality can be identified. Primary headache associated with sexual activity (PHASA) is one of the subgroups of primary headaches. PHASA is a benign form of headache and lifetime prevalence is estimated to be 1% to 1.6% in the general population. A 38-year-old man was admitted to outpatient clinic reporting history of severe headaches during sexual intercourse for the last 2 months...
April 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28895706/-neonatal-renal-abscess-a-diagnostic-and-therapeutic-challenge-a-clinical-case
#20
Sebastián Argañaraz Gonçalves, Enrique Casanueva, Silvia Filipis, Carla Gandini, M Vanesa Rodríguez, Adriana Santiago, Aída Vázquez, Roberto Vagni
Renal abscess is a rare disease in newborn, but severe consequences can occur: sepsis with high mortality, renal scar formation and risk of chronic renal failure. A neonate with unilateral renal abscess due to Staphylococcus aureus is reported, with septicemia, with no other suppurative focus, nor with urinary malformation, with good clinical evolution with intravenous antibiotics and without surgical treatment, but with renal scars sequel. From this case, the strategies of diagnosis, treatment and followup of the renal abscess in a neonate are analyzed, emphasizing the early diagnosis to avoid renal scars...
October 1, 2017: Archivos Argentinos de Pediatría
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