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https://www.readbyqxmd.com/read/28318194/-craniopharyngioma-and-klinefelter-syndrome-during-the-pubertal-transition-a-diagnostic-challenge
#1
Yamile Mocarbel, Graciela Arébalo de Cross, Marie C Lebrethon, Albert Thiry, Albert Beckersd, Hernan Valdes-Socin
Craniopharyngioma is the most common pituitary tumor in childhood. It can compromise the pubertal development because of its evolution or treatment. Syndrome of Klinefelter is the most common cause of hipergonadotrophic hypogonadism in males. The concomitant presentation of both entities is extremely low (1/109) and the pathophysiological association is questionned. We present the case of a 18-year-old Belgian patient. He had a diagnosis of craniopharyngioma in childhood and he presented with panhypopituitarism after radiotherapy and surgical treatment...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28306687/directly-measured-physical-function-in-cardiac-rehabilitation
#2
Jason L Rengo, Patrick D Savage, Joan C Shaw, Philip A Ades
PURPOSE: The Short Physical Performance Battery (SPPB) is a strong predictor for risk of physical disability in older adults. Roughly half of individuals participating in phase II cardiac rehabilitation (CR) are 65 years or older, many presenting with low aerobic capacities and may be at increased risk for physical disability. METHODS: The cohort consisted of 196 consecutive patients (136 men), aged 65 years or older, entering CR who were prospectively evaluated by the SPPB...
March 15, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28299718/have-the-causes-of-revision-for-total-and-unicompartmental-knee-arthroplasties-changed-during-the-past-two-decades
#3
Gro S Dyrhovden, Stein Håkon L Lygre, Mona Badawy, Øystein Gøthesen, Ove Furnes
BACKGROUND: Revisions after knee arthroplasty are expected to increase, and the epidemiology of failure mechanisms is changing as new implants, technology, and surgical techniques evolve. QUESTIONS/PURPOSES: (1) Was there improvement in survival for TKA and unicompartmental knee arthroplasty (UKA) when comparing two consecutive 11-year periods with similar followups in a national registry? (2) Were there changes in the causes of revision during the two times? (3) Could the changes in revision causes be attributed to patient or implant characteristics? METHODS: A total of 60,623 TKAs (2426 revisions) and 7648 UKAs (725 revisions) were selected from the Norwegian Arthroplasty Register and analyzed based on year of primary surgery: 1994 to 2004 (Period 1) and 2005 to 2015 (Period 2)...
March 15, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28291425/long-term-outcomes-of-epilepsy-surgery-in-85-pediatric-patients-followed-up-for-over-10-years-a-retrospective-survey
#4
Hiroshi Hosoyama, Kazumi Matsuda, Tadahiro Mihara, Naotaka Usui, Koichi Baba, Yushi Inoue, Takayasu Tottori, Toshiaki Otsubo, Yumi Kashida, Koji Iida, Hirofumi Hirano, Ryosuke Hanaya, Kazunori Arita
OBJECTIVE The aim of this study was to investigate the treatment outcomes and social engagement of patients who had undergone pediatric epilepsy surgery more than 10 years earlier. METHODS Between 1983 and 2005, 110 patients younger than 16 years underwent epilepsy surgery at the National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders. The authors sent a questionnaire to 103 patients who had undergone follow-up for more than 10 years after surgery; 85 patients (82.5%) responded. The survey contained 4 categories: seizure outcome, use of antiepileptic drugs, social participation, and general satisfaction with the surgical treatment (resection of the epileptic focus, including 4 hemispherectomies)...
March 3, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28290184/ultrasound-contrast-enhanced-study-as-an-imaging-biomarker-for-anti-cancer-drug-treatment-preliminary-study-with-paclitaxel-in-a-xenograft-mouse-tumor-model-secondary-publication
#5
Hak Jong Lee, Sung Il Hwang, Jonghoe Byun, Hoon Young Kong, Hyun Sook Jung, Mira Kang
Purpose: The purpose of this study was to assess tumor angiogenesis using contrast-enhanced ultrasonography (CEUS) of human prostate cancer cells (PC3) that were implanted in mice before and after paclitaxel injection. Methods: Twelve mice were injected with human prostate cancer cells (PC3). The mice were grouped into two groups; one was the paclitaxel-treated group (n=6) and the other was the control group (n=6). Before administering paclitaxel into the peritoneal cavity, baseline CEUS was performed after the administration of 500 μL (1×108 microbubbles) of contrast agent...
February 14, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28290117/what-influence-does-progression-of-a-nonhealing-rotator-cuff-tear-have-on-shoulder-pain-and-function
#6
Yoon Sang Jeon, Rag Gyu Kim, Sang-Jin Shin
BACKGROUND: There have been numerous reports of clinical outcomes associated with tendon healing after repair that suggest a nonhealed tendon has a negative effect on postoperative clinical outcomes. However, to our knowledge, there has been no report on the relationship between tear size progression of nonhealed tendons and clinical outcomes. QUESTIONS/PURPOSES: (1) Do patients with healed arthroscopic rotator cuff repairs have better outcomes, less pain, and more strength than patients whose repair did not heal? (2) In patients with nonhealed rotator cuff tendons, does tear size progression (increase or decrease) affect outcomes, pain, and strength? (3) Is there continued improvement beyond 6 months in outcomes, pain, and strength; and how do the improvements differ based on whether the tear size has increased or decreased? METHODS: Between May 2008 and December 2012, 647 patients underwent arthroscopic rotator cuff repair for full-thickness tears at our institution...
March 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28272497/the-nucleus-accumbens-and-ketamine-treatment-in-major-depressive-disorder
#7
Chadi G Abdallah, Andrea Jackowski, Ramiro Salas, Swapnil Gupta, João R Sato, Xiangling Mao, Jeremy D Coplan, Dikoma C Shungu, Sanjay J Mathew
Animal models of depression repeatedly showed stress-induced nucleus accumbens (NAc) hypertrophy. Recently, ketamine was found to normalize this stress-induced NAc structural growth. Here, we investigated NAc structural abnormalities in major depressive disorder (MDD) in two cohorts. Cohort A included a cross-sectional sample of 34 MDD and 26 healthy control (HC) subjects, with high-resolution magnetic resonance imaging (MRI) to estimate NAc volumes. Proton MR spectroscopy ((1)H MRS) was used to divide MDD subjects into two subgroups: glutamate-based depression (GBD) and non-GBD...
March 8, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28265884/d%C3%A3-bridement-and-reconstrucion-improve-postoperative-sagittal-alignment-in-kyphotic-cervical-spinal-tuberculosis
#8
Zhimin Pan, Jiaquan Luo, Limin Yu, Yiwei Chen, Junlong Zhong, Zhiyun Li, Zhaoxun Zeng, Pingguo Duan, Yoon Ha, Kai Cao
BACKGROUND: Cervical spinal tuberculosis is relatively common in some developing countries. It erodes vertebrae and discs, which sometimes results in cervical kyphosis and myelopathy. However, to our knowledge, no studies have evaluated improvements to patient-reported outcomes among patients who undergo surgical cervical sagittal realignment after kyphotic cervical spinal tuberculosis has been treated by débridement and reconstruction. QUESTIONS/PURPOSES: (1) Can a spine with kyphotic cervical spinal tuberculosis be returned to normal alignment and fused successfully? (2) Will patient-reported outcomes be improved with this intervention? (3) Are patient-reported outcomes correlated with realignment? METHODS: Forty-six patients with kyphotic cervical spinal tuberculosis were evaluated in this retrospective study...
March 6, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28265327/neuropathic-bladders-investigation-and-treatment-through-their-lifetime
#9
REVIEW
Peter D Metcalfe
The child with a neuropathic bladder requires lifelong dedicated care. Just as each patient presents with unique physiology, each phase of their life presents varying challenges. The primary concern for our patients is their renal health, but continence and independence also play significant roles. Most patients can be managed conservatively, but a myriad of surgical options are also available, reinforcing our emphasis on individualized care. Appropriate pre-surgical planning is required to ensure the right patient receives the best operation for his/her wants and needs...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28262517/visual-acuity-oncologic-and-toxicity-outcomes-with-103-pd-vs-125-i-plaque-treatment-for-choroidal-melanoma
#10
Kirtesh R Patel, Roshan S Prabhu, Jeffrey M Switchenko, Mudit Chowdhary, Caroline Craven, Pia Mendoza, Hasan Danish, Hans E Grossniklaus, Thomas M Aaberg, Thomas Aaberg, Sahitya Reddy, Elizabeth Butker, Chris Bergstrom, Ian R Crocker
PURPOSE: To evaluate outcomes of choroidal melanoma patients treated with (125)I or (103)Pd plaque brachytherapy. METHODS AND MATERIALS: From 1993 to 2012, our institution treated 160 patients with (103)Pd (56.1%) and 125 patients with (125)I (43.9%) plaque brachytherapy. Tumor outcomes, visual acuity (VA), and toxicity were compared. Multivariate analyses (MVAs) and propensity score analysis were used to help address differences in baseline characteristics. RESULTS: Median followup was longer for (125)I patients, 52...
March 2, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28262516/brachytherapy-as-part-of-the-conservative-treatment-for-primary-and-recurrent-vulvar-carcinoma
#11
P Castelnau-Marchand, A Escande, R Mazeron, E Bentivegna, A Cavalcanti, S Gouy, C Baratiny, P Maroun, P Morice, C Haie-Meder, C Chargari
PURPOSE: There are only scarce data on the place of brachytherapy (BT) for treatment of vulvar carcinoma. Our institutional experience of interstitial BT for vulvar carcinoma patients is reported. METHODS AND MATERIALS: Clinical records of patients receiving low-dose-rate or pulsed-dose-rate BT as part of the primary treatment for primary/recurrent vulvar squamous cell carcinoma or as part of postoperative treatment between 2000 and 2015 were included. Patients, tumors, and treatment characteristics as well as clinical outcome were examined...
March 2, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28260477/doppler-ultrasonography-findings-during-recovery-period-of-transplanted-kidney-after-infarction-and-necrosis-due-to-renal-vein-thrombosis-a-case-report
#12
Funda Ulu Ozturk, Nihal Uslu, Eda Yilmaz Akcay, Mehmet Haberal
A 47-year-old male patient underwent living-related renal transplant. On day 3 posttransplant, without evidence of associated clinical symptoms, the patient's serum creatinine levels had increased. The patient was given immunosuppressive medication, and a followup Doppler ultrasonography revealed hypoechoic areas in the inferior pole of the renal parenchyma. Eventually, on day 25, there was no perfusion in the superior and inferior poles of the transplanted kidney. No venous flow was shown in the middle segment, and only arterial vascularization with a high resistive index and negative diastolic phase was observed...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28255418/28-year-late-spermatic-cord-relapse-of-a-testicular-non-seminomatous-germ-cell-tumour-managed-robotically
#13
James R Hayes, Michael A S Jewett, Robert J Hamilton
We present a patient who relapsed symptomatically 28 years post-orchiectomy, initially followed by active surveillance for clinical stage I non-seminomatous germ cell tumour (CSI NSGCT). His relapse was localized to the pelvis, managed with robotic surgery, and achieved a complete resection with tumour markers normalized. We highlight the current Princess Margaret guidelines for followup of CSI NSGCT and discuss the trade-off between lifelong radiographic surveillance to detect the very small risk of late relapse...
July 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28255411/structured-assessment-and-followup-for-patients-with-hereditary-kidney-tumour-syndromes
#14
Jean-Baptiste Lattouf, Stephen E Pautler, M Neil Reaume, Raymond H Kim, Melanie Care, Jane Green, Alan So, Philippe D Violette, Issam Saliba, Philippe Major, Shane Silver, Richard Leicht, Joan Basiuk, Simon Tanguay, Michael A S Jewett, Darrel Drachenberg
INTRODUCTION: Optimal clinical assessment and subsequent followup of patients with or suspected of having a hereditary renal cell carcinoma syndrome (hRCC) is not standardized and practice varies widely. We propose protocols to optimize these processes in patients with hRCC to encourage a more uniform approach to management that can then be evaluated. METHODS: A review of the literature, including existing guidelines, was carried out for the years 1985-2015. Expert consensus was used to define recommendations for initial assessment and followup...
July 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28253942/delayed-fracture-healing-in-diabetics-with-distal-radius-fractures
#15
S Pscherer, G H Sandmann, S Ehnert, A K Nussler, U Stöckle, T Freude
PURPOSE OF THE STUDY Diabetics may have an increased fracture risk, depending on disease duration, quality of metabolic adjustment and extent of comorbidities, and on an increased tendency to fall. The aim of this retrospective one-centre study consisted in detecting differences in fracture healing between patients with and without diabetes mellitus. Data of patients with the most common fracture among older patients were analyzed. MATERIAL AND METHODS Classification of distal radius fractures was established according to the AO classification...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28250143/the-effect-of-widespread-pain-on-knee-pain-worsening-incident-knee-osteoarthritis-oa-and-incident-knee-pain-the-multicenter-oa-most-study
#16
Lisa C Carlesso, Jingbo Niu, Neil A Segal, Laura A Frey-Law, Cora E Lewis, Michael C Nevitt, Tuhina Neogi
OBJECTIVE: Whether widespread pain (WSP) affects the risk of developing knee pain or knee osteoarthritis (OA) is unknown and could enhance understanding of pain mechanisms in OA. METHODS: Subjects from the Multicenter OA (MOST) study, a US National Institutes of Health-funded prospective cohort of older adults with or at risk of knee OA, were characterized regarding WSP, defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, excluding knee pain at 60 months (baseline)...
March 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28248725/3d-tissue-microarray-controls-a-potential-standardization-solution
#17
Charles W Myers, Sonal Bhimji-Patel, Mark Rees, Syed Ashraf Imam, Cynthia Cohen
The use of controls is a hallmark for quality control in anatomic pathology. However, standardization of controls between laboratories has been a significant issue. Differential processing techniques between institutions and a multitude of preanalytical difficulties can result in different immunostain intensities. So called histoid controls, xenografts or culture cell lines, have been discussed in the past but with no recent followup. Herein is presented a histoid termed a 3D tissue microarray control (3D TMAC) control to help alleviate the burgeoning need for control standardization...
February 28, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28244059/medical-errors-in-neonatal-intensive-care-unit-at-benha-university-hospital-egypt
#18
REVIEW
Ahmed N El-Shazly, Mahmoud A Al-Azzouny, Doaa R Soliman, Neveen T Abed, Sameh S Attia
This study was conducted in the neonatal intensive care unit of Benha University Hospital, Egypt from 1 August 2012 to the 31 January 2013 to identify medical errors and to determine the risk factors and consequences of these errors. Errors were detected by follow-up of neonates and review of reports including nursing followup sheets, resident progression notes and investigation reports. We detected 3819 errors that affected 97% of neonates. Types of errors included 403 medication errors (10.55% of total errors), 652 errors in daily routine procedures (17...
February 21, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28237429/prostate-mri-for-brachytherapists-anatomy-and-technique
#19
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
PURPOSE: To present an overview of mp MRI techniques necessary for high-resolution imaging of prostate. METHODS: We summarize examples from our clinical experience and concepts from the current literature that illustrate normal prostate anatomy on multiparametric MRI (mp MRI). RESULTS: Our experience regarding optimal mp MRI image acquisition is provided, as well as a summary of prostate and periprostatic anatomy and anatomical variants that pose challenges for BT...
February 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28237254/early-secondary-bone-grafting-in-children-with-alveolar-cleft-does-not-modify-the-risk-of-maxillary-permanent-canine-impaction-at-the-age-of-10-years
#20
Flavie Kleinpoort, Hugo Ferchichi, Anissa Belkhou, Paul Tramini, Michèle Bigorre, Guillaume Captier
OBJECTIVE: The risk of maxillary permanent canine retention is elevated in children with cleft lip and palate (CLP). This study compared this risk in 10 ± 1 year-old patients with unilateral CLP (UCLP) who underwent or not early maxillary bone grafting at the age of 6 ± 1 years. METHODS: Retrospective, controlled monocentric and observational study with the following inclusion criteria: patients with UCLP, isolated cleft, pre-surgery orthodontic maxillary expansion, same surgical protocol, same surgical team...
January 31, 2017: Journal of Cranio-maxillo-facial Surgery
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