keyword
https://read.qxmd.com/read/38438636/from-periphery-to-center-untold-story-of-pure-neuritic-leprosy-an-electrophysiological-study
#1
JOURNAL ARTICLE
Sanjeev Kumar Bhoi, Yuvraj Lahre, Menka Jha, Suprava Naik, Suvendu Purkait, Priyanka Samal, Gautom Kumar Saharia, Mukesh Kumar, Pritimayee Behera
BACKGROUND: Pure neuritic leprosy (PNL) is uncommon form of leprosy involving peripheral nerves. Some isolated case reports have shown imaging changes in the central nervous system (CNS) and also impairment in visual evoked potential (VEP), somatosensory evoked potential (SSEP) and brain stem auditory-evoked potentials (BAEPs) parameters in PNL, but there is lack of large study. This prospective observational study evaluates impairment in these central conduction studies among PNL patients...
March 4, 2024: Acta Neurologica Belgica
https://read.qxmd.com/read/38423575/idiopathic-membranous-nephropathy-and-synchronous-mononeuritis-multiplex-secondary-to-idiopathic-small-vessel-vasculitis
#2
JOURNAL ARTICLE
Kalpa Jayanatha, Ashutosh Kumar, Mark Sapsford, Mark Simpson
Membranous nephropathy has been associated with demyelinating polyneuropathies and antiglomerular membrane disease; however, an association with vasculitic neuropathy has not been described. This case describes a patient with biopsy-proven idiopathic membranous nephropathy and synchronous mononeuritis multiplex secondary to idiopathic small vessel vasculitis, who presented with lower limb microvascular ischaemia, peripheral neuropathy and active urinary sediment. Her extensive non-invasive screening for immunological disease and radiological investigations for occult malignancy were unremarkable...
February 29, 2024: BMJ Case Reports
https://read.qxmd.com/read/38414086/igg4-disease-with-multiorgan-involvement-a-case-report
#3
JOURNAL ARTICLE
M N Vidanapathirana, D Wijayaratne
BACKGROUND: IgG4-related disease (IgG4RD) is a rare fibroinflammatory disease with multiorgan involvement. It presents insidiously over several years and can be a diagnostic enigma. Delays in diagnosis occur due to failure to consider IgG4 as a differential diagnosis, atypical presentations, and an insidious clinical course. CASE PRESENTATION: We report the case of a 70-year-old Sri Lankan man with pulmonary, renal, and neurological involvement of IgG4-related disease...
February 28, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38333608/mononeuritis-multiplex-following-immune-checkpoint-inhibitors-in-malignant-pleural-mesothelioma
#4
JOURNAL ARTICLE
Antonio Farina, Manon Escalere, Matthias Dion, Martin Moussy, Antoine Pegat, Macarena Villagrán-García, Perrine Devic, Anaïde Lamiral, Antoine Seyve, Karine Aure, Adrien Wang, Lucas Gorza, Nathalie Streichenberger, Thierry Maisonobe, Jerome Honnorat, Cristina Birzu, Dimitri Psimaras, David Weisenburger-Lile, Bastien Joubert
INTRODUCTION: Mononeuritis multiplex is frequently related to vasculitic neuropathy and has been reported only sporadically as an adverse event of immune checkpoint inhibitors. METHODS: Case series of three patients with mononeuritis multiplex-all with mesothelioma-identified in the databases of two French clinical networks (French Reference Center for Paraneoplastic Neurological Syndromes, Lyon; OncoNeuroTox, Paris; January 2015-October 2022) set up to collect and investigate n-irAEs on a nationwide level...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38170096/tendon-transfer-to-treat-radial-nerve-palsy-following-covid-19-infection
#5
Sydney A Thai, Anirudh Kulkarni, Ajul Shah
Multiple manifestations have been associated with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Among them are mononeuritis multiplex (MNM) and other neurological complications, whose connection to coronavirus disease 2019 (COVID-19) is still unclear. One of the most common sites of nerve injury is the radial nerve, which can be treated with both nerve or tendon transfer. In this case report, a patient who was afflicted with severe COVID-19 infection and developed mono neuritis multiplex after prolonged mechanical ventilation with radial nerve palsy was treated with multiple tendon transfers...
November 2023: Curēus
https://read.qxmd.com/read/38126794/-eosinophilic-granulomatosis-with-polyangiitis-a-case-report
#6
JOURNAL ARTICLE
Olafur Orri Sturluson, Olafur Palsson, Einar Hjaltested, Dora Ludviksdottir
A 72-year-old woman presented to the emergency department due to worsening dyspnea. She had been diagnosed with asthma a year earlier. At arrival, her oxygen saturation was only 84%. During lung auscultation, wheezing was noted over all lung fields. A blood test showed a significant increase in eosinophils in peripheral blood, highest value of 1.4 x 10E9/L. Further investigations in the respiratory ward showed a positive MPO-ANCA, which, together with clinical features of asthma, chronic rhinosinusitis with polyps, mononeuritis multiplex and eosinophilia, led to the diagnosis of eosinophilic granulomatosis with polyangiitis, or what used to be called Churg-Strauss syndrome...
January 2024: Læknablađiđ
https://read.qxmd.com/read/38115776/eosinophilic-granulomatosis-with-polyangiitis-sequential-use-of-mepolizumab-following-rituximab-for-inadequate-asthma-control-despite-vasculitis-remission
#7
JOURNAL ARTICLE
B Cremonezi Lammoglia, L De Aguiar Trevise, T Paslar Leal, M Pereira Lopes Vieira Pinto, G Hasselmann, N Salles Rosa Neto
We report the case of a 54-year-old woman with antineutrophilic cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis presenting with mononeuritis multiplex, intestinal hemorrhage, cardiomyopathy, fever, and worsening asthma symptoms. She was initially treated with steroids and cyclophosphamide but eventually required rituximab to control a vasculitis flare. However, her asthmatic symptoms did not improve, despite attaining vasculitis remission. Symptoms abated only after the treatment transition to mepolizumab...
December 19, 2023: Reumatismo
https://read.qxmd.com/read/38054689/acute-paraplegia-in-a-patient-with-eosinophilic-granulomatosis-and-polyangiitis-with-20-years-of-evolution-case-report
#8
JOURNAL ARTICLE
Mariana Guerra, Daniela Marado, Jorge Fortuna
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and necrotizing vasculitis of small and medium vessels with a heterogeneous presentation, multiorgan involvement, characterized by the presence of chronic rhinosinusitis, asthma, and peripheral eosinophilia. Nervous system involvement is frequent, especially in the peripheral nervous system (PNS), in the form of mononeuritis multiplex. However, subarachnoid and cerebral hemorrhage, cerebral infarction, cranial nerve palsies, and cortical blindness have also been reported in the literature...
December 5, 2023: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/38034645/severe-mononeuritis-multiplex-as-a-rare-case-of-neuro-leptospirosis-a-case-report
#9
Sofiati Dian, Ni Made Gitaria Sylvana Ratmadewi, Suryani Gunadharma, Ahmad Rizal Ganiem
Leptospirosis is a zoonotic bacterial disease caused by infection of spirochetes of the genus Leptospira . While typically self-limiting and non-fatal, severe manifestations can arise, including various neurological complications that are often overlooked. This case study presents a 59-year-old man with serologically positive Leptospirosis, who subsequently developed asymmetrical progressive leg weakness, severe back pain, and overflow incontinence suggestive of mononeuritis multiplex. Doxycycline treatment was started and intended to last for seven days...
November 2023: Heliyon
https://read.qxmd.com/read/37900606/antineutrophil-cytoplasmic-antibody-associated-vasculitis-with-predominant-truncal-muscle-weakness-a-retrospective-case-series
#10
JOURNAL ARTICLE
Joe Nemoto, Hideaki Nishihara, Taro Yasuhi, Ryota Sato, Michiaki Koga, Takashi Kanda, Masayuki Nakamori
INTRODUCTION: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) frequently leads to mononeuritis multiplex, which are characterized by distal weakness associated with sensory disturbances. Although AAV has also been reported to be associated with myopathy, the pathogenesis and characteristics remain unclear. We aimed to show the clinical and laboratory findings in AAV-associated myopathy. METHODS: This retrospective single-center study included patients with the diagnosis of AAV who had been admitted to the neurology department and had biopsy specimens of muscle and/or nerve tissue...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37828257/-vasculitides
#11
REVIEW
Thomas Rauen, Kristian Vogt, Stefan Krämer
In everyday clinical practice, immunologically mediated systemic vasculitides are among the rare diseases, meaning that basic knowledge of major symptoms and indicative laboratory findings is crucial for the inclusion of these complex clinical entities in differential diagnostic considerations. For many years, systemic vasculitides have been classified according to the primarily affected vessel size, distinguishing large, medium-sized, and small vessels. Pain is very often one of the main complaints of these diseases, be it, for example, the temporally accentuated headache in giant cell arteritis, the early morning myalgias in the shoulder and hip girdle in polymyalgia rheumatica, or the mononeuritis multiplex in eosinophilic granulomatosis with polyangiitis...
October 12, 2023: Der Schmerz
https://read.qxmd.com/read/37822434/b-cell-lymphoma-presenting-with-seventh-cranial-nerve-palsy-and-mononeuritis-multiplex-a-case-report-and-comprehensive-literature-review
#12
Yongzhen Chen, Yilun Wang, John Corrigan, Anza B Memon
Diagnosing B-cell lymphoma-associated mononeuritis multiplex is challenging due to its rarity and the potential co-existence of other causes of mononeuritis multiplex. Here, we report a case of a 74-year-old male who initially presented with left cranial neuropathies followed by right-sided extremity weakness with hyporeflexia, right facial involvement, and subsequently asymmetric weakness and multifocal muscle wasting. Minor improvements were observed with multiple rounds of steroid treatment. The diffuse large B-cell lymphoma diagnosis was eventually established six months later upon a repeat mediastinal lymph node biopsy and cerebrospinal fluid cytology...
September 2023: Curēus
https://read.qxmd.com/read/37753013/mononeuritis-multiplex-due-to-hansen-s-disease-a-look-through-ultrasound-and-electrodiagnosis
#13
Wilmer Santiago Herrera Malpica, Paula Vanessa Muñetones Hernández, Nathalia Maria Perez Becerra, Jorge Nicolas Muñoz Rodriguez, Jorge Arturo Diaz Ruiz
Hansen's disease is caused by Mycobacterium leprae. This bacillus can invade the peripheral nerves asymmetrically, including the ulnar, median, and radial nerves, causing mononeuritis multiplex. We present the case of a 41-year-old man with a history of Hansen's disease with sensory and motor symptoms. Electrodiagnostic studies and ultrasound showed asymmetric lesions of the median, ulnar, and radial nerves. Because this is the main complication of this pathology, electrodiagnosis is clearly valuable for its diagnosis, demonstrating axonal and myelin involvement, as well as signs of denervation and reinnervation...
August 2023: Curēus
https://read.qxmd.com/read/37701004/benign-intracranial-hypertension-a-rare-manifestation-of-neurosarcoidosis
#14
Prashant Dubey, Satish Nirhale, Shalesh Rohatgi, Pranit Khandait
Sarcoidosis is an immune-mediated disease that can involve multiple systems. Sarcoidosis of the nervous system or neurosarcoidosis may present as cranial mononeuropathy, hypothalamic involvement, aseptic meningitis, granulomatous inflammation in the brain parenchyma or spinal cord, peripheral neuropathy, and, in rare cases, as myopathy and benign intracranial hypertension. The most common cranial nerve involvement is the facial nerve, which can present as unilateral or bilateral facial nerve palsy, often with recurrent episodes...
August 2023: Curēus
https://read.qxmd.com/read/37615230/-not-available
#15
JOURNAL ARTICLE
Anne Møller Witt, Tina Dysgaard
Vasculitic neuropathy (VN) may affect the peripheral nervous system alone (non-systemic vasculitic neuropathy (NSVN)) or be part of a systemic vasculitis. Studies indicate that NSVN is ascommon as other inflammatory neuropathies but is underdiagnosed, probably becausethe clinical phenotype is very heterogenous and vary from sub-acute painful mononeuritis multiplex to progressive, symmetric polyneuropathy. Since the irreversible nerve damage can be reduced with immunosuppressants, early recognition of VN is important...
August 7, 2023: Ugeskrift for Laeger
https://read.qxmd.com/read/37548380/aseptic-meningitis-followed-by-mononeuritis-multiplex-in-a-patient-with-primary-sj%C3%A3-gren-s-syndrome
#16
JOURNAL ARTICLE
Hideki Nakamura, Yutaka Tanikawa, Masahiro Nishihara, Masako Tsukamoto, Yosuke Nagasawa, Kumiko Akiya, Naotoshi Natori, Noboru Kitamura, Tadateru Takayama, Hideto Nakajima
A 38-year-old woman was admitted to hospital because of fever and headache. Increased cerebrospinal cell count and protein without evidence of infection led to a diagnosis of aseptic meningitis. Although she improved with acyclovir and glyceol, she experienced left forearm pain and sensory disturbance with drop fingers. Poor derivation of compound muscle action potentials in the left radial nerve was observed, leading to a diagnosis of mononeuritis multiplex with sensorimotor neuropathy. Because the patient had primary Sjögren's syndrome with anti-Ro/SS-A antibody and salivary gland hypofunction, treatment with methylprednisolone, intravenous immunoglobulin, and intravenous cyclophosphamide was followed by oral glucocorticoid therapy...
August 2023: Journal of International Medical Research
https://read.qxmd.com/read/37525576/new-onset-severe-eosinophilic-granulomatosis-with-polyangiitis-following-the-third-dose-of%C3%A2-mrna-covid-19-vaccine-a-case-report
#17
JOURNAL ARTICLE
Salah Mahdi, Anwar I Joudeh, Krishnamoorthy Sundara Raman, Samia Ait Faqih, Mohammed Ibrahim Alhatou, Muhammad Faisal Wadiwala, Mohammed Akhtar, Abdo Qaid Ahmed Lutf
Eosinophilic granulomatosis with polyangiitis (EGPA) is a complex multifactorial disease that results in multisystemic inflammation of the small- and medium-sized arteries. The exact pathogenesis of this syndrome is poorly understood, but it is postulated to result from a combination of eosinophilic dysfunction, genetic predisposition, and the development of autoantibodies after exposure to an unknown stimulus. We describe a case of new-onset EGPA following the third dose of the Pfizer-BioNTech mRNA vaccine in an infection-naive middle-aged man with a background history of allergic respiratory symptoms...
July 25, 2023: Modern rheumatology case reports
https://read.qxmd.com/read/37484549/a-case-of-eosinophilic-granulomatous-polyangiitis-with-concurrent-central-and-peripheral-nervous-system-involvement
#18
Anusha Challa, Sai Sirisha, Harsh Khandelia, Mihir Parekh, Anuja Patil, Sita Jayalakshmi
Eosinophilic granulomatous polyangiitis (EGPA) like other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has multisystemic involvement. It commonly manifests with prodromal pulmonary involvement as asthma, chronic sinusitis followed by systemic vasculitic complications associated with blood and tissue eosinophilia. Central nervous system manifestations at presentation are uncommon compared with peripheral nervous system involvement. Vasculitic neuropathy in EGPA commonly presents as mononeuritis multiplex but rarely as polyradiculopathy...
July 2023: Oxford Medical Case Reports
https://read.qxmd.com/read/37360749/article-topic-neuropathies-due-to-infections-and-antimicrobial-treatments
#19
REVIEW
Andrés M De León, Rocio Garcia-Santibanez, Taylor B Harrison
PURPOSE OF EVIEW: The aim of this review is to discuss the presentation, diagnosis, and management of polyneuropathy (PN) in selected infections. Overall, most infection related PNs are an indirect consequence of immune activation rather than a direct result of peripheral nerve infection,  Schwann cell infection, or toxin production, though note this review will describe infections that cause PN through all these mechanisms. Rather than dividing them by each infectious agent separately, we have grouped the infectious neuropathies according to their presenting phenotype, to serve as a guide to clinicians...
June 10, 2023: Current Treatment Options in Neurology
https://read.qxmd.com/read/37346885/mononeuropathy-multiplex-as-an-uncommon-presentation-of-intravascular-lymphoma-a-case-report
#20
Bahram Haqi-Ashtiani, Parichehr Moghaddam, Farzaneh Barzkar, Ali Zare Mehrjerdi, Mostafa Almasi-Dooghaee
KEY CLINICAL MESSAGE: Although intravascular lymphoma rarely presents with peripheral neuropathy, learning about this presentation can lead to timely diagnosis and improved prognosis in patients with intravascular lymphoma. ABSTRACT: A 64-year-old man presented with asymmetric paresthesia and subsequent weakness of his feet and a 10 kg weight loss over 40 days. Electrodiagnostic studies revealed distal axonal sensory-motor polyneuropathy with ongoing axonal loss...
June 2023: Clinical Case Reports
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