keyword
MENU ▼
Read by QxMD icon Read
search

smoking and placebo

keyword
https://www.readbyqxmd.com/read/29773262/-smoking-cessation-pharmacological-strategies-different-from-standard-treatments
#1
REVIEW
M Underner, J Perriot, G Peiffer, G Harika-Germaneau, N Jaafari
INTRODUCTION: Three drugs are used as an aid for smoking cessation: nicotine replacement therapy (NRT), varenicline and bupropion. Standard pharmacological strategies have proven their efficacy but may have poor efficacy, especially among "Hard-core smokers" who display low smoking abstinence rates and high relapse rates. OBJECTIVES: Systematic literature review of data on pharmacological strategies for smoking cessation which are different from standard treatments...
May 14, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29765212/the-effect-of-conjugated-linoleic-acid-on-oxidative-stress-and-matrix-metalloproteinases-2-and-9-in-patients-with-copd
#2
Somaieh Matin, Ali Nemati, Hassan Ghobadi, Reza Alipanah-Moghadam, Lotfollah Rezagholizadeh
Background: Natural antioxidants in foods may be used in prevention and treatment of oxidative stress and inflammation in COPD. Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients. Materials and methods: This clinical trial study was conducted on 90 (supplement group=45 and control group=45) COPD patients in Ardabil city, Iran, in 2015...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29765102/the-effects-of-cannabidiol-on-impulsivity-and-memory-during-abstinence-in-cigarette-dependent-smokers
#3
C Hindocha, T P Freeman, M Grabski, H Crudgington, A C Davies, J B Stroud, R K Das, W Lawn, C J A Morgan, H V Curran
Acute nicotine abstinence in cigarette smokers results in deficits in performance on specific cognitive processes, including working memory and impulsivity which are important in relapse. Cannabidiol (CBD), the non-intoxicating cannabinoid found in cannabis, has shown pro-cognitive effects and preliminary evidence has indicated it can reduce the number of cigarettes smoked in dependent smokers. However, the effects of CBD on cognition have never been tested during acute nicotine withdrawal. The present study therefore aimed to investigate if CBD can improve memory and reduce impulsivity during acute tobacco abstinence...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763835/predictors-of-reduced-smoking-quantity-among-recovering-alcohol-dependent-men-in-a-smoking-cessation-trial
#4
Matthew J Worley, Melodie Isgro, Jaimee L Heffner, Soo Yong Lee, Belinda E Daniel, Robert M Anthenelli
INTRODUCTION: Adults with alcohol dependence (AD) have exceptionally high smoking rates and poor smoking cessation outcomes. Discovery of factors that predict reduced smoking among AD smokers may help improve treatment. This study examined baseline predictors of smoking quantity among AD smokers in a pharmacotherapy trial for smoking cessation. METHODS: The sample includes male, AD smokers (N = 129) with 1-32 months of alcohol abstinence who participated in a 12-week trial of medication (topiramate vs...
May 9, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29753799/predictors-of-erectile-function-normalization-in-men-with-erectile-dysfunction-treated-with-placebo
#5
John P Mulhall, Martin Carlsson, Vera Stecher, Li-Jung Tseng
BACKGROUND: Clinical study and practice data have shown sildenafil improves sexual function in men with erectile dysfunction (ED). However, some men treated with placebo in double-blind, placebo-controlled sildenafil studies also report improved erectile function as measured by International Index of Erectile Function (IIEF)-Erectile Function Domain (EFD) scores. AIM: This analysis estimated the relationship between post-baseline IIEF-EFD scores and demographic variables, including co-morbidities, in men with ED receiving placebo in flexible-dose sildenafil studies...
May 9, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29752828/cannabis-smoking-impairs-driving-performance-on-simulator-and-real-driving-a-randomized-double-blind-placebo-controlled-crossover-trial
#6
Joëlle Micallef, Julien Dupouey, Elisabeth Jouve, Romain Truillet, Bruno Lacarelle, Jack Taillard, Agnès Daurat, Colas Authié, Olivier Blin, Olivier Rascol, Pierre Philip, Daniel Mestre
Driving experiments in real conditions are considered as a "gold standard" to evaluate the effects of drugs on driving performance. Several constraints are difficult to manage in these conditions, so driving simulation appears as the best alternative. A preliminary comparison is crucial before being able to use driving simulation as a valid evaluation method. The aim of this study was to design a driving simulation method for assessing drugs effects on driving. We used cannabis (THC) as a positive control and assessed whether THC affects driving performance in simulation conditions and whether these effects are consistent with performance in real driving conditions...
May 12, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29742264/chlorhexidine-for-prevention-of-alveolar-osteitis-a-randomised-clinical-trial
#7
Diego Halabi, Jose Escobar, Cyntia Alvarado, Nicolette Martinez, Carlos Muñoz
Objective To determine the effectiveness of chlorhexidine 0.12% mouthwash (CHX) after tooth extraction for the prevention of alveolar osteitis (AO). Material and methods We conducted a double-blind randomised clinical trial stratified by risk factors. We enrolled a cohort of 822 patients who underwent dental extractions, and were considered to be at risk of developing AO (previous surgical site infection, traumatic extraction, and tobacco smoking). After extraction, patients were randomly allocated for CHX group or placebo group, matched by risk factors...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29729429/perioperative-antibiotic-prophylaxis-in-open-tracheostomy-a-preliminary-randomized-controlled-trial
#8
Pichit Sittitrai, Chatmanee Siriwittayakorn
BACKGROUND: The efficacy of perioperative antibiotic prophylaxis for prevention of wound infection in open tracheostomy has been minimally studied and remains controversial. METHODS: A preliminary double-blind, randomized, placebo-controlled trial was conducted. A total of 159 patients who underwent open tracheostomy were enrolled, and 88 patients were excluded because of lack of desire to participate in research, emergency condition, administration of other antibiotics, immunocompromise, or cervical skin infection...
May 2, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29714034/cannabidiol-reverses-attentional-bias-to-cigarette-cues-in-a-human-experimental-model-of-tobacco-withdrawal
#9
C Hindocha, T P Freeman, M Grabski, J B Stroud, H Crudgington, A C Davies, R K Das, W Lawn, C J A Morgan, H V Curran
BACKGROUND AND AIMS: Cannabidiol (CBD), a non-intoxicating cannabinoid, may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side-effects and research showing it may modify drug cue salience. We used an experimental medicine approach with dependent cigarette smokers to investigate if (1) overnight nicotine abstinence, compared with satiety, will produce greater attentional bias (AB), higher pleasantness ratings of cigarette-related stimuli and increased craving and withdrawal; (2) CBD in comparison to placebo, would attenuate AB, pleasantness of cigarette-related stimuli, craving and withdrawal and not produce any side-effects...
May 1, 2018: Addiction
https://www.readbyqxmd.com/read/29713728/empagliflozin-in-women-with-type-2-diabetes-and-cardiovascular-disease-an-analysis-of-empa-reg-outcome%C3%A2
#10
Bernard Zinman, Silvio E Inzucchi, Christoph Wanner, Uwe Hehnke, Jyothis T George, Odd Erik Johansen, David Fitchett
AIMS/HYPOTHESIS: The global epidemic of type 2 diabetes affects women and men equally; however, the relative impact on the cardiovascular (CV) system appears greater for women than men when compared with peers without diabetes. Furthermore, women are often under-represented in CV outcome trials, resulting in less certainty about the impact of CV prevention therapies across the sexes. The EMPA-REG OUTCOME® trial, which included 28.5% women, found that empagliflozin, given in addition to standard of care, reduced the risk of CV death by 38%, heart failure (HF) hospitalisation by 35% and a composite endpoint for incident or worsening nephropathy by 39%...
April 30, 2018: Diabetologia
https://www.readbyqxmd.com/read/29701814/oxytocin-reduces-cigarette-consumption-in-daily-smokers
#11
Kathryne Van Hedger, Meredith J Kushner, Royce Lee, Harriet de Wit
Introduction: Despite widespread knowledge of the dangers of cigarette consumption, smoking continues to be a public health concern. One compound that has shown potential for treatment in preclinical models is the neuropeptide oxytocin (OT). The purpose of the present study was to examine the effects of intranasal oxytocin on cigarette craving, behavioral economic demand for cigarettes, and cigarette consumption, in regular smokers after 18 hours of abstinence. Method: Otherwise healthy daily smokers (n= 35) completed two sessions where they received OT (40 IU intranasal) or placebo (PBO) and completed measures of craving and cigarette demand, and were given 6 opportunities to smoke partial cigarettes in exchange for money...
April 26, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29693495/a-randomized-clinical-trial-of-nicotine-preloading-for-smoking-cessation-in-people-with-posttraumatic-stress-disorder
#12
Eric A Dedert, Paul A Dennis, Patrick S Calhoun, Michelle F Dennis, Jean C Beckham
OBJECTIVE: To determine whether augmenting standard smoking cessation treatment by wearing an active nicotine patch before the smoking quit date improves rates of smoking cessation in individuals with posttraumatic stress disorder (PTSD), and to explore mechanisms of treatment response such as decreased cigarette craving and symptom relief from smoking. METHODS: Double-blind parallel randomized controlled trial in 81 people with PTSD who smoked cigarettes. Participants were recruited from Veterans Affairs outpatient clinics and flyers in the community...
April 25, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29692206/pilot-investigation-of-the-effect-of-carvedilol-on-stress-precipitated-smoking-lapse-behavior
#13
Terril L Verplaetse, Andrea H Weinberger, Rebecca L Ashare, Brian P Pittman, Julia M Shi, Jeanette M Tetrault, Meaghan Lavery, Sherry A McKee
INTRODUCTION: Separate α1- and β-adrenergic antagonists have shown efficacy in reducing nicotine-motivated behaviors in rodents and humans, supporting a role for the noradrenergic system in mediating the reinforcing properties of drugs of abuse. However, the effect of the combined α1- and β-adrenergic antagonist, carvedilol, on stress-related smoking is unknown. METHODS: Using a well-established human laboratory model of stress-precipitated smoking-lapse behavior, we examined whether carvedilol (0 or 50 mg/day; between subject, n=17 per group), administered to steady-state, would attenuate the ability to resist smoking following stress imagery (vs...
April 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29689485/the-effect-of-high-dose-dronabinol-oral-thc-maintenance-on-cannabis-self-administration
#14
Nicolas J Schlienz, Dustin C Lee, Maxine L Stitzer, Ryan Vandrey
BACKGROUND: There is a clear need for advancing the treatment of cannabis use disorders. Prior research has demonstrated that dronabinol (oral THC) can dose-dependently suppress cannabis withdrawal and reduce the acute effects of smoked cannabis. The present study was conducted to evaluate whether high-dose dronabinol could reduce cannabis self-administration among daily users. METHODS: Non-treatment seeking daily cannabis users (N = 13) completed a residential within-subjects crossover study and were administered placebo, low-dose dronabinol (120 mg/day; 40 mg tid), or high-dose dronabinol (180-240 mg/day; 60-80 mg tid) for 12 consecutive days (order counterbalanced)...
April 17, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29683704/how-do-electronic-cigarettes-affect-cravings-to-smoke-or-vape-parsing-the-influences-of-nicotine-and-expectancies-using-the-balanced-placebo-design
#15
Amanda M Palmer, Thomas H Brandon
OBJECTIVE: Although electronic cigarettes (e-cigarettes) are frequently initiated for smoking cessation, results from the first two clinical trials testing this suggest that the perceived benefits of vaping may be influenced by non-nicotine factors, including cognitive outcome expectancies. The current study investigated the separate and combined effects of nicotine delivery and outcome expectancies on cravings for cigarettes and e-cigarettes using a balanced-placebo experiment. METHOD: Drug dosage (contains nicotine or not) was crossed with instructional set (told nicotine or non-nicotine) during ad lib e-cigarette use sessions by 128 current e-cigarette users (52 identifying as current cigarette smokers or "dual users")...
May 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29679432/an-rct-with-the-combination-of-varenicline-and-bupropion-for-smoking-cessation-clinical-implications-for-front-line-use
#16
Paul M Cinciripini, Jennifer A Minnix, Charles E Green, Jason D Robinson, Jeffrey M Engelmann, Francesco Versace, David W Wetter, Sanjay Shete, Maher Karam-Hage
BACKGROUND AND AIMS: Despite the availability of several efficacious smoking cessation treatments, less than 25% of smokers who quit remain abstinent 1 year post treatment. This study aimed to determine if varenicline and bupropion combination treatment would result in higher abstinence rates than varenicline alone. DESIGN: A double-blind, randomized, parallel groups smoking cessation clinical trial in which participants were exposed to 12 weeks of treatment and followed for 12 months...
April 21, 2018: Addiction
https://www.readbyqxmd.com/read/29676824/the-safety-effectiveness-and-cost-effectiveness-of-cytisine-in-achieving-six-month-continuous-smoking-abstinence-in-tuberculosis-patients-protocol-for-a-double-blind-placebo-controlled-randomised-trial
#17
Omara Dogar, Deepa Barua, Melanie Boeckmann, Helen Elsey, Razia Fatima, Rhian Gabe, Rumana Huque, Ada Keding, Amina Khan, Daniel Kotz, Eva Kralikova, James N Newell, Iveta Nohavova, Steve Parrott, Anne Readshaw, Lottie Renwick, Aziz Sheikh, Kamran Siddiqi
BACKGROUND AND AIMS: Tuberculosis (TB) patients who quit smoking have much better disease outcomes than those who continue to smoke. Behavioural support combined with pharmacotherapy is the most effective strategy in helping people to quit, in general populations. However, there is no evidence for the effectiveness of this strategy in TB patients who smoke. We will assess the safety, effectiveness and cost-effectiveness of cytisine - a low-cost plant-derived nicotine substitute - for smoking cessation in TB patients compared with placebo, over and above brief behavioural support...
April 20, 2018: Addiction
https://www.readbyqxmd.com/read/29663982/nicotine-lozenges-in-the-relief-of-behaviorally-provoked-craving
#18
Mitchell Nides, Gilbert Marava Shanga, Amanda Bishop, William D Becker
OBJECTIVES: Environmental cues may precipitate nicotine cravings in smokers. We present 2 studies exploring the efficacy of nicotine mini lozenges to reduce nicotine craving in smokers following behavioral provocation. METHODS: Healthy smokers aged ≥18 years enrolled. In Study 1, participants were stratified by number of cigarettes smoked daily; Study 2 enrolled only heavy smokers. After an abstinence period, participants engaged in behavioral provocation to induce nicotine craving before receiving a nicotine mini lozenge (Study 1: 1...
May 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29660034/e-cigarettes-may-support-smokers-with-high-smoking-related-risk-awareness-to-stop-smoking-in-the-short-run-preliminary-results-by-randomized-controlled-trial
#19
Marianna Masiero, Claudio Lucchiari, Ketti Mazzocco, Giulia Veronesi, Patrick Maisonneuve, Costantino Jemos, Emanuela Omodeo Salè, Stefania Spina, Raffaella Bertolotti, Gabriella Pravettoni
Introduction: E-cigarettes may be positively used in tobacco cessation treatments. However, neither the World Health Organization nor the American Food and Drug Administration has recognized them as effective cessation aids. Data about the efficacy and safety of e-cigarettes are still limited and controversial. Methods: This was a double-blind randomized controlled study. The main aim was to assess the efficacy of the use of e-cigarettes in a tobacco cessation program with a group of chronic smokers voluntarily involved in long-term lung cancer screening...
April 11, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29650283/-interventions-for-smoking-cessation-in-2018
#20
REVIEW
J Abdul-Kader, G Airagnes, S D'almeida, F Limosin, A-L Le Faou
Smoking cessation treatments have been proved effective to stop smoking. For pharmacological treatments, nicotine replacement therapies (NRT) as well as bupropion allow to increase 6 month-abstinence rates by more than 80% in comparison with placebo while varenicline prescription doubles success rates in the same conditions. These results mean that for 10 smokers who quit with placebo, 18 are expected to quit with NRT or bupropion and 28 are expected to quit with varenicline. Varenicline is 50% more effective than nicotine patch and 70% more effective than nicotine gum...
April 9, 2018: Revue de Pneumologie Clinique
keyword
keyword
103942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"