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https://www.readbyqxmd.com/read/29650283/-interventions-for-smoking-cessation-in-2018
#1
REVIEW
J Abdul-Kader, G Airagnes, S D'almeida, F Limosin, A-L Le Faou
Smoking cessation treatments have been proved effective to stop smoking. For pharmacological treatments, nicotine replacement therapies (NRT) as well as bupropion allow to increase 6 month-abstinence rates by more than 80% in comparison with placebo while varenicline prescription doubles success rates in the same conditions. These results mean that for 10 smokers who quit with placebo, 18 are expected to quit with NRT or bupropion and 28 are expected to quit with varenicline. Varenicline is 50% more effective than nicotine patch and 70% more effective than nicotine gum...
April 9, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29642561/%C3%AE-nicotinamide-adenine-dinucleotide-%C3%AE-nad-inhibits-atp-dependent-il-1%C3%AE-release-from-human-monocytic-cells
#2
Sebastian Daniel Hiller, Sarah Heldmann, Katrin Richter, Innokentij Jurastow, Mira Küllmar, Andreas Hecker, Sigrid Wilker, Gabriele Fuchs-Moll, Ivan Manzini, Günther Schmalzing, Wolfgang Kummer, Winfried Padberg, J Michael McIntosh, Jelena Damm, Anna Zakrzewicz, Veronika Grau
While interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine essential for host defense, high systemic levels cause life-threatening inflammatory syndromes. ATP, a stimulus of IL-1β maturation, is released from damaged cells along with β-nicotinamide adenine dinucleotide (β-NAD). Here, we tested the hypothesis that β-NAD controls ATP-signaling and, hence, IL-1β release. Lipopolysaccharide-primed monocytic U937 cells and primary human mononuclear leukocytes were stimulated with 2'(3')- O -(4-benzoyl-benzoyl)ATP trieethylammonium salt (BzATP), a P2X7 receptor agonist, in the presence or absence of β-NAD...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29627622/investigating-the-role-of-ion-pair-strategy-in-regulating-nicotine-release-from-patch-mechanistic-insights-based-on-intermolecular-interaction-and-mobility-of-pressure-sensitive-adhesive
#3
Qiaoyun Li, Xiaocao Wan, Chao Liu, Liang Fang
The aim of this study was to prepare a drug-in-adhesive patch of nicotine (NIC) and use ion-pair strategy to regulate drug delivery rate. Moreover, the mechanism of how ion-pair strategy regulated drug release was elucidated at molecular level. Formulation factors including pressure sensitive adhesives (PSAs), drug loading and counter ions (C4 , C6 , C8 , C10 , and C12 ) were screened. In vitro release experiment and in vitro transdermal experiment were conducted to determine the rate-limiting step in drug delivery process...
April 5, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29617633/reducing-racial-ethnic-tobacco-cessation-disparities-via-cognitive-behavioral-therapy-design-of-a-dualsite-randomized-controlled-trial
#4
Monica Webb Hooper, David J Lee, Vani N Simmons, Karen O Brandon, Michael H Antoni, Marina Unrod, Taghrid Asfar, John B Correa, Tulay Koru-Sengul, Thomas H Brandon
Racial/ethnic disparities in tobacco cessation are such that U.S. minorities have greater difficulty quitting compared to White non-Hispanics. Group differences in distress (i.e., perceived stress and depressive symptoms) may contribute to cessation disparities. The allostasis model of health suggests that the toll of chronic stress experienced by racial/ethnic minorities may lead to dysregulation of the physiological stress system and drug use. Previous research suggests that group cognitive behavioral therapy (CBT) for tobacco cessation addresses distress as a modifiable mechanism and has the potential to reduce/eliminate disparities...
April 1, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29609056/smoking-cessation-treatment-outcomes-among-people-with-and-without-mental-and-substance-use-disorders-an-observational-real-world-study
#5
João Mauricio Castaldelli-Maia, Aline Rodrigues Loreto, Bruna Beatriz Sales Guimarães-Pereira, Carlos Felipe Cavalcanti Carvalho, Felipe Gil, Fernanda Piotto Frallonardo, Flávia Ismael, Arthur Guerra de Andrade, Antonio Ventriglio, Kimber P Richter, Dinesh Bhugra
BACKGROUND: There is a lack of studies evaluating smoking cessation treatment protocols which include people with and without mental and substance use disorders (MSUD), and which allows for individuals with MSUD undergoing their psychiatric treatment. METHODS: We compared treatment success between participants with (n = 277) and without (n = 419) MSUD among patients in a 6-week treatment provided by a Brazilian Psychosocial Care Center (CAPS) from 2007 to 2013...
March 30, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29547920/nicotine-addiction-management-following-surgery-a-quality-improvement-approach-in-the-post-anesthesia-care-unit
#6
Barry A Finegan, Daniel Roblin, Fadi Hammal
Quality problem: For smokers, hospital admission is accompanied by forced involuntary nicotine abstinence due to smoke-free site/grounds policies. An audit of patients admitted to our surgical wards revealed that identification of smoking status was inadequate and that nicotine addiction management (NAM) was infrequently offered. The project aimed to enhance both these metrics by initiating NAM in the post anesthesia care unit (PACU). Initial assessment: Out of 744 patients admitted to our PACU in August 2015, 54% had their smoking status documented...
March 14, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29514317/reinforcement-enhancing-effects-of-nicotine-via-patch-and-nasal-spray
#7
Kenneth A Perkins, Joshua L Karelitz, Margaret C Boldry
Introduction: Confirming preclinical findings, nicotine in humans (via smoking) enhances reinforcement from non-drug rewards. Recent demonstration of similar effects with nicotine via e-cigarettes suggests they may also occur when using nicotine replacement therapies (NRT). Methods: Effects of nicotine via NRT patch or nasal spray were assessed on responding reinforced by music, video, or monetary rewards, or for no reward (control). Non-treatment seeking smokers (N=31) participated in three virtually identical experimental sessions, each following overnight abstinence (CO≤10 ppm)...
March 3, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29510223/using-facebook-to-address-smoking-and-heavy-drinking-in-young-adults-protocol-for-a-randomized-controlled-trial
#8
Danielle E Ramo, Manpreet Kaur, Ella S Corpuz, Derek D Satre, Kevin Delucchi, Sandra A Brown, Judith J Prochaska
INTRODUCTION: Tobacco and alcohol often are used simultaneously by young adults, and their co-use is associated with greater health consequences than from single use. Social media platforms offer low cost and highly accessible channels to reach and engage young people in substance use interventions. The current trial seeks to compare the Facebook Tobacco Status Project (TSP) smoking cessation intervention to an intervention targeting both tobacco use and heavy episodic drinking (TSP + ALC) among young adults who use both substances...
March 3, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29487212/target-selectivity-of-septal-cholinergic-neurons-in-the-medial-and-lateral-entorhinal-cortex
#9
Srinidhi Desikan, David E Koser, Angela Neitz, Hannah Monyer
The entorhinal cortex (EC) plays a pivotal role in processing and conveying spatial information to the hippocampus. It has long been known that EC neurons are modulated by cholinergic input from the medial septum. However, little is known as to how synaptic release of acetylcholine affects the different cell types in EC. Here we combined optogenetics and patch-clamp recordings to study the effect of cholinergic axon stimulation on distinct neurons in EC. We found dense cholinergic innervations that terminate in layer I and II (LI and LII)...
February 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29477596/nicotine-facilitates-synaptic-depression-in-layer-v-pyramidal-neurons-of-the-mouse-insular-cortex
#10
Hiroki Toyoda
The insular cortex is known to play a pivotal role in addiction to nicotine. Long-term depression (LTD) in the central nervous system is a major form of synaptic plasticity which is involved in learning and memory and in various pathological conditions such as nicotine addiction. Until now, effects of nicotine on LTD were mainly examined in the hippocampus and striatum, and there is no report showing the effects of nicotine on LTD in the insular cortex. In the present study, I show for the first time that nicotine facilitates LTD which is induced by combination of presynaptic stimulation with postsynaptic depolarization (paired training) in layer 5 pyramidal neurons of the mouse insular cortex using whole-cell patch-clamp recordings...
February 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29458324/smoking-cessation-therapy-in-australian-and-new-zealand-intensive-care-units-a-multicentre-point-prevalence-study
#11
Forbes McGain, Matthew L Durie, Samantha Bates, Christine M Polmear, Jason Meyer, Craig J French
OBJECTIVE: To obtain an accurate estimate of smoking prevalence and smoking cessation support practices, including nicotine replacement therapy (NRT), in Australian and New Zealand intensive care units (ICUs). DESIGN, SETTING AND PARTICIPANTS: Cross-sectional, observational study using data obtained from adult ICUs participating in the Australian and New Zealand Intensive Care Society Clinical Trials Group Point Prevalence Program in 2016. MAIN OUTCOME MEASURES: Prevalence and intensity of current smoking, baseline characteristics of smokers in comparison with non-smokers and frequency of NRT use while admitted to the ICU...
March 2018: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/29444289/knowledge-attitude-and-behaviors-of-health-professionals-towards-smoking-cessation-in-primary-healthcare-settings
#12
Abdullah Matouq, Yousef Khader, Albaraa Khader, Anas Al-Rabadi, Mousa Al Omari, Ibrahim Iblan, Nihaya Al-Sheyab
This study aimed to assess the behaviors of multiple health professionals in primary healthcare settings in Jordan towards smoking cessation counseling and to determine the barriers to effective smoking cessation behaviors. A survey of 456 health professionals in primary healthcare settings was conducted. A self-administrated questionnaire was used to collect the data. About half of health professionals reported that they usually ask patients about smoking status and advise them to stop smoking (51.4% and 50...
February 10, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29427655/nicotinic-acetylcholine-receptors-are-associated-with-ketamine-induced-neuronal-apoptosis-in-the-developing-rat-retina
#13
Lingqi Gao, Junde Han, Jie Bai, Jing Dong, Sen Zhang, Mazhong Zhang, Jijian Zheng
Early synchronized spontaneous network activity is a hallmark of the brain growth spurt period, during which general anesthetics cause widespread neuronal apoptosis and subsequent cognitive dysfunction. However, the relationship of such activity to anesthetic-induced neuronal apoptosis remains to be determined. In this study, we utilized patch-clamp electrophysiological recording, immunohistochemistry, and TUNEL assays to investigate the potential roles of spontaneous network activity in ketamine-induced neuronal apoptosis during early development...
February 7, 2018: Neuroscience
https://www.readbyqxmd.com/read/29403297/a-cost-effectiveness-analysis-of-varenicline-for-smoking-cessation-using-data-from-the-eagles-trial
#14
Christine L Baker, Guilhem Pietri
Background: The cost-effectiveness of varenicline has been demonstrated in the US health care setting using the Benefits of Smoking Cessation on Outcomes (BENESCO) model to simulate the lifetime direct costs and consequences of a hypothetical cohort of US adult smokers who make a single attempt to quit. The aim of this study was to undertake an updated cost-effectiveness analysis, using current epidemiology inputs and recently published smoking cessation data from the Evaluating Adverse Events in a Global Smoking Cessation Study (EAGLES), the largest clinical trial of smoking cessation pharmacotherapies conducted to date...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29394003/pharmacokinetic-evaluation-of-two-nicotine-patches-in-smokers
#15
Scott Rasmussen, Kathleen Halabuk Horkan, Mitchell Kotler
Smoking continues to be a major preventable cause of early mortality worldwide, and nicotine replacement therapy has been demonstrated to increase rates of abstinence among smokers attempting to quit. Nicotine transdermal systems (also known as nicotine patches) attach to the skin via an adhesive layer composed of a mixture of different-molecular-weight polyisobutylenes (PIBs) in a specific ratio. This randomized, single-dose, 2-treatment, crossover pharmacokinetic (PK) trial assessed the bioequivalence of nicotine patches including a replacement PIB adhesive (test) compared with the PIB adhesive historically used on marketed patches (reference)...
February 2, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29385578/factors-influencing-the-impact-of-pharmacogenomic-prescribing-on-adherence-to-nicotine-replacement-therapy-a-qualitative-study-of-participants-from-a-randomized-controlled-trial
#16
Alison J Wright, Stephen Sutton, David Armstrong, Paul Aveyard, Ann Louise Kinmonth, Theresa M Marteau
Pharmacogenomics may improve health outcomes in two ways: by more precise and therefore more effective prescribing, tailored to genotype, and by increasing perceived effectiveness of treatments and so motivation for adherence. Little is known about patients' experiences of, and reactions to, receiving pharmacogenomically tailored treatments. The aim of this study was to explore the impact of pharmacogenomic prescribing of nicotine replacement therapy (NRT) on smokers' initial expectations of quit success, adherence, and perceived important differences from previous quit attempts...
January 29, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29364128/investigating-the-effect-of-perinatal-nicotine-exposure-on-dopaminergic-neurons-in-the-vta-using-mirna-expression-profiles
#17
Renee F Keller, Pinar Kanlikilicer, Andrei Dragomir, Yantao Fan, Yasemin M Akay, Metin Akay
Maternal smoking during pregnancy is associated with developmental, cognitive, and behavioral disorders, including low birth weight, attention deficit hyperactivity disorder, learning disabilities, and drug abuse later in life. Nicotine activates the reward-driven behavior characteristic of drug abuse. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain, which are stimulated by nicotine and other stimuli, are widely implicated in the natural reward pathway that is known to contribute to addiction...
December 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29351507/-i-smoke-like-this-to-suppress-these-issues-that-are-flaws-of-my-character-challenges-and-facilitators-of-cessation-among-smokers-with-bipolar-disorder
#18
Jaimee L Heffner, Noreen L Watson, Jennifer B McClure, Robert M Anthenelli, Sarah Hohl, Jonathan B Bricker
OBJECTIVE: Smokers with bipolar disorder (BD) have low rates of successful quitting, yet no prior studies have evaluated the process of quitting among these smokers in the context of a current quit attempt. To facilitate development of more effective interventions, we conducted a qualitative exploration of challenges and facilitators of quitting in an intervention study for smokers with BD. METHODS: Participants were adult daily smokers with BD (n = 10) who completed a 10-week smoking cessation intervention consisting of Acceptance and Commitment Therapy (ACT) and nicotine patch...
January 19, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29321008/effects-of-a-culturally-specific-tobacco-cessation-intervention-among-african-american-quitline-enrollees-a-randomized-controlled-trial
#19
Monica Webb Hooper, Kelly Carpenter, Michael Payne, Ken Resnicow
BACKGROUND: African Americans suffer disproportionately from tobacco-related illness and have more difficulty quitting smoking than other racial/ethnic groups. Previous research indicates that African American treatment-seekers are high utilizers of tobacco quitlines, yet cessation rates via quitlines are lower relative to whites. The goal of the present study is to test the effectiveness of adding a culturally specific, video-based, adjunct to standard quitline care. It is hypothesized that the integration of an evidence-based intervention (Pathways to Freedom: Leading the Way to a Smoke-Free Community©; PTF) into quitline services will increase cessation and treatment engagement compared to control conditions, and that effects will be moderated by sociocultural factors (e...
January 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29313652/lung-cancer-smoking-cessation
#20
REVIEW
Kelly M Latimer
Smoking cessation for patients who smoke should be a top priority for physicians. Nicotine dependence should be considered a chronic disease, with the expectation that relapse is normal. The US Preventive Services Task Force (USPSTF) recommends that physicians screen all adults for tobacco use, advise them to stop using tobacco, and provide behavioral interventions and Food and Drug Administration-approved pharmacotherapy for cessation to adults who use tobacco. It also recommends use of the 5 As (ie, Ask, Advise, Assess, Assist, Arrange) in discussing tobacco use with patients...
January 2018: FP Essentials
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