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https://www.readbyqxmd.com/read/28521035/beyond-quitting-any-additional-impact-of-mailing-free-nicotine-patches-to-current-smokers
#1
John A Cunningham, Vladyslav Kushnir, Peter Selby, Rachel F Tyndale, Laurie Zawertailo, Scott T Leatherdale
No abstract text is available yet for this article.
May 18, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28500373/effects-of-varenicline-versus-transdermal-nicotine-replacement-therapy-on-cigarette-demand-on-quit-day-in-individuals-with-substance-use-disorders
#2
Cara M Murphy, James MacKillop, Rosemarie A Martin, Jennifer W Tidey, Suzanne M Colby, Damaris J Rohsenow
RATIONALE: Cigarette demand is a behavioral economic measure of the relative value of cigarettes. Decreasing the value of cigarette reinforcement may help with quitting smoking. OBJECTIVES: This study aimed to evaluate the effects of initial use of varenicline (VAR) versus nicotine replacement therapy (NRT) on demand for cigarettes on quit day among smokers with substance use disorders (SUD) and to determine whether reduced demand was associated with subsequent abstinence from smoking at 1 and 3 months...
May 13, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28498504/varenicline-versus-nicotine-patch-with-brief-advice-for-smokers-with-substance-use-disorders-with-or-without-depression-effects-on-smoking-substance-use-and-depressive-symptoms
#3
Damaris J Rohsenow, Jennifer W Tidey, Rosemarie A Martin, Suzanne M Colby, Robert M Swift, Lorenzo Leggio, Peter M Monti
AIMS: Varenicline was compared with transdermal nicotine (NRT) for smokers with current substance use disorders (SUD) for effects on 3-month smoking abstinence (primary outcome) and, secondarily, on 3 and 6 month abstinence while adjusting for medication adherence, and on additional smoking and substance use outcomes. Moderation by major depressive disorder history (MDD) and adherence were investigated. DESIGN: Double-blind double-placebo controlled randomized design, stratifying by MDD, gender and nicotine dependence, with 3 and 6 months follow up...
May 12, 2017: Addiction
https://www.readbyqxmd.com/read/28496108/alpha7-nicotinic-acetylcholine-receptor-agonist-promotes-retinal-ganglion-cell-function-via-modulating-gabaergic-presynaptic-activity-in-a-chronic-glaucomatous-model
#4
Xujiao Zhou, Yun Cheng, Rong Zhang, Gang Li, Boqi Yang, Shenghai Zhang, Jihong Wu
Alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists can prevent glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs). However, the neuroprotective effects and the mechanism of action of PNU-282987, an α7-nAChR agonist, in a chronic in vivo rat glaucoma model are poorly understood. We found that elevated intraocular pressure (IOP) downregulated retinal α7-nAChR expression. Electroretinography revealed that the amplitude of the photopic negative response (PhNR) decreased in parallel with the loss of RGCs caused by elevated IOP...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493744/does-menthol-cigarette-use-moderate-the-effect-of-nicotine-metabolism-on-short-term-smoking-cessation
#5
Nancy C Jao, Anna K Veluz-Wilkins, Matthew J Smith, Allison J Carroll, Sonja Blazekovic, Frank T Leone, Rachel F Tyndale, Robert A Schnoll, Brian Hitsman
The nicotine metabolite ratio (NMR) has been shown to predict response to the transdermal nicotine patch, such that faster nicotine metabolism is associated with a lower abstinence rate. Menthol cigarette use, versus nonmenthol cigarette use, slows nicotine metabolism and therefore may attenuate the effect of NMR on smoking abstinence. In this study, we evaluated whether cigarette type (menthol vs. nonmenthol) modified the association between NMR and short-term abstinence. This was a secondary analysis examining treatment in the first 8 weeks of 21 mg/day nicotine patch therapy in a completed clinical trial (n = 474)...
June 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28489501/smoking-cessation-treatment-for-patients-with-mental-disorders-using-cbt-and-combined-pharmacotherapy
#6
Aline Rodrigues Loreto, Carlos Felipe Cavalcanti Carvalho, Fernanda Piotto Fralonardo, Flavia Ismael, Arthur Guerra de Andrade, João Maurício Castaldelli-Maia
OBJECTIVES: To investigate smoking treatment effectiveness and retention in a population with and without mental disorders (MD). Participants received cognitive-behavioral therapy (CBT) plus nicotine patch alone or in combination with other medications (i.e., gum, bupropion, or nortriptyline) for smoking cessation treatment in a Brazilian Psychosocial Care Center unit (CAPS), taking into account sociodemographics and smoking profile covariates. METHODS: Comparison of treatment success (7-day point prevalence abstinence at the end of the treatment) and retention (presence of the individual in all of the 4 medical consultations and 6 group sessions) in two subsamples of patients with MD (n = 267) and without MD (n = 397) who were included in a 6-week treatment provided by a CAPS from 2007 to 2013...
May 10, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28489321/nicotine-deprivation-attenuates-panic-reactivity-in-smokers-findings-from-a-placebo-controlled-nicotine-patch-study
#7
Kenneth Abrams, Sam Krimmel, Stacey Johnson, Kate Cieslowski, Helen Strnad, Arielle Melum, Caroline Kryder
BACKGROUND: Prospective studies consistently find that smoking is a risk factor for the development of panic disorder (PD). A possible explanation is that nicotine deprivation promotes heightened sensitivity to bodily sensations and/or arterial carbon dioxide (CO2 ). Abrams et al. (2011) previously found that, in response to a CO2 rebreathing challenge, smokers experiencing more (vs. less) intense nicotine withdrawal had more severe panic symptoms and a stronger urge to escape. However, participants were aware of the last time they smoked, leaving unclear the extent to which fear reactivity was influenced by the pharmacologic effects of nicotine deprivation versus beliefs regarding when nicotine was most recently used...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28487481/functional-genomics-in-brugia-malayi-reveal-diverse-muscle-nachrs-and-differences-between-cholinergic-anthelmintics
#8
Saurabh Verma, Sudhanva Srinivas Kashyap, Alan Patrick Robertson, Richard John Martin
Many techniques for studying functional genomics of important target sites of anthelmintics have been restricted to Caenorhabditis elegans because they have failed when applied to animal parasites. To overcome these limitations, we have focused our research on the human nematode parasite Brugia malayi, which causes elephantiasis. Here, we combine single-cell PCR, whole muscle cell patch clamp, motility phenotyping (Worminator), and dsRNA for RNAi for functional genomic studies that have revealed, in vivo, four different muscle nAChRs (M-, L-, P-, and N-)...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28486709/anhedonia-its-dynamic-relations-with-craving-negative-affect-and-treatment-during-a-quit-smoking-attempt
#9
Jessica W Cook, Stephanie T Lanza, Wanghuan Chu, Timothy B Baker, Megan E Piper
Introduction: Research shows that abstinence from tobacco leads to a withdrawal-related decrement in responsivity to nondrug rewards (ie, anhedonia). However, it remains unclear how anhedonia relates to other key withdrawal symptoms and withdrawal-related constructs over time. We analyzed ecological momentary assessment data to examine whether a decrement in response to rewards during a 10-day period following quitting shows a pattern of associations with other variables (ie, treatment, tobacco dependence, negative affect, and craving) that is consistent with anhedonia being a tobacco withdrawal symptom...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28479554/temporal-trends-of-psychosociobehavioral-factors-underlying-tobacco-use-a-semi-automated-exploratory-analysis-of-peer-to-peer-communication-in-a-health-related-online-community
#10
Vishnupriya Sridharan, Trevor Cohen, Nathan Cobb, Sahiti Myneni
Online communities have been an integral part of tobacco cessation programs. They are rich in content, and offer insights into factors affecting an individual's behavior change efforts. We used word representation techniques to infer implicit meaning embedded in messages exchanged in a health-related online community. Our analysis of peer interactions revealed that individuals factor in safety, glamour, expense, and media projection when choosing a form of nicotine intake. When choosing pharmacotherapy techniques, individuals focus on brands, dosage, and side effects associated with each form (e...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28470846/systematic-review-interventions-for-abdominal-pain-management-in-inflammatory-bowel-disease
#11
REVIEW
C Norton, W Czuber-Dochan, M Artom, L Sweeney, A Hart
BACKGROUND: Abdominal pain is frequently reported by people with inflammatory bowel disease (IBD), including in remission. Pain is an under-treated symptom. AIM: To systematically review evidence on interventions (excluding disease-modifying interventions) for abdominal pain management in IBD. METHODS: Databases (MEDLINE, EMBASE, PsycInfo, CINAHL, Scopus, Cochrane Library) were searched (February 2016). Two researchers independently screened references and extracted data...
May 4, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28469856/monocular-diplopia-associated-migraine-like-headache-induced-by-nicotine-withdrawal
#12
Xiaoping He, Alvina Munaf, Evgeny Idrisov, George Everett, Sami K Saikaly, Esther Kim, Khalid Abusaada, Vincent Hsu
We describe an extremely rare case of migraine-associated monocular diplopia developed in a 23-year-old man after sudden cessation of smoking. The physical examination and brain MRI scan were unremarkable. The symptoms resolved after starting nicotine patch. We reviewed the literature and discussed the diagnosis and possible mechanism of this phenomenon.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28462940/chronic-nicotine-alters-corticostriatal-plasticity-in-the-striatopallidal-pathway-mediated-by-nr2b-containing-silent-synapses
#13
Jianxun Xia, Allison M Meyers, Jeff A Beeler
Smoking is the leading cause of preventable death in the U.S. and success rates for quitting remain low. High relapse rates are attributed to pervasive nicotine-reinforced associative learning of incentive cues that is highly resistant to extinction. Why such learning is so persistent is poorly understood but may arise as a consequence of neuroadaptations in synaptic plasticity induced by chronic nicotine. We used whole-cell patch clamp recording to investigate the effect of chronic nicotine (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium spiny neurons in the indirect, striatopallidal pathway in dorsolateral striatum...
May 2, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28415979/behavioral-activation-for-smoking-cessation-and-mood-management-following-a-cardiac-event-results-of-a-pilot-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Andrew M Busch, Erin M Tooley, Shira Dunsiger, Elizabeth A Chattillion, John Fani Srour, Sherry L Pagoto, Christopher W Kahler, Belinda Borrelli
BACKGROUND: Smoking cessation following hospitalization for Acute Coronary Syndrome (ACS) significantly reduces subsequent mortality. Depressed mood is a major barrier to cessation post-ACS. Although existing counseling treatments address smoking and depression independently in ACS patients, no integrated treatment addresses both. We developed an integrated treatment combining gold standard cessation counseling with behavioral activation-based mood management; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS)...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28409740/quit-methods-used-by-us-adult-cigarette-smokers-2014-2016
#15
Ralph S Caraballo, Paul R Shafer, Deesha Patel, Kevin C Davis, Timothy A McAfee
To quantify the prevalence of 10 quit methods commonly used by adult cigarette smokers, we used data from a nationally representative longitudinal (2014-2016) online survey of US adult cigarette smokers (n = 15,943). Overall, 74.7% of adult current cigarette smokers used multiple quit methods during their most recent quit attempt. Giving up cigarettes all at once (65.3%) and reducing the number of cigarettes smoked (62.0%) were the most prevalent methods. Substituting some cigarettes with e-cigarettes was used by a greater percentage of smokers than the nicotine patch, nicotine gum, or other cessation aids approved by the US Food and Drug Administration...
April 13, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28403383/neural-signatures-of-cognitive-flexibility-and-reward-sensitivity-following-nicotinic-receptor-stimulation-in-dependent-smokers-a-randomized-trial
#16
Elise Lesage, Sarah E Aronson, Matthew T Sutherland, Thomas J Ross, Betty Jo Salmeron, Elliot A Stein
Importance: Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid cessation treatment. Objective: To independently assess the effects of nicotine dependence and stimulation of the nicotinic acetylcholine receptor on the ability to interpret valence information (reward sensitivity) and subsequently alter behavior as reward contingencies change (cognitive flexibility) in a probabilistic reversal learning task...
April 12, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28401564/a-double-blind-randomized-placebo-controlled-trial-of-oral-naltrexone-for-heavy-drinking-smokers-seeking-smoking-cessation-treatment
#17
Christopher W Kahler, Patricia A Cioe, Golfo K Tzilos, Nichea S Spillane, Lorenzo Leggio, Susan E Ramsey, Richard A Brown, Stephanie S O'Malley
BACKGROUND: Post hoc analyses of 2 randomized controlled trials suggest naltrexone may reduce alcohol use and improve smoking cessation outcomes among heavy drinkers receiving smoking cessation treatment. However, no studies have been conducted specifically to examine naltrexone for this purpose or to test whether naltrexone has benefit when added to smoking cessation counseling that explicitly addresses heavy drinking. METHODS: We recruited heavy-drinking smokers from the community and randomized them to receive 10 weeks of either (i) 50 mg naltrexone (n = 75) or (ii) placebo (n = 75) daily...
April 12, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28398690/use-of-nicotine-replacement-therapy-in-young-people-entering-custody-in-new-south-wales-australia
#18
Leigh Haysom, Dianne Lawrence, Donna Mellish, Peter Burns, Pariza Khale, Ariana Arulampalam, Catherine Stapylton
AIM: To describe the prevalence of nicotine dependence and acceptance of nicotine replacement therapy (NRT) in young people entering custody, where smoking is not allowed. METHODS: Cross-sectional study in 2013. SETTING: All New South Wales Juvenile Justice Centres. PARTICIPANTS: Incarcerated youth, aged 12-21 years. MAIN EXPOSURES: gender, age, ethnicity, cannabis use. MAIN OUTCOMES: rates of smoking, cannabis use, nicotine dependence, NRT acceptance...
April 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28396143/lethal-effects-of-an-insecticidal-spider-venom-peptide-involve-positive-allosteric-modulation-of-insect-nicotinic-acetylcholine-receptors
#19
Monique J Windley, Irina Vetter, Richard J Lewis, Graham M Nicholson
κ-Hexatoxins (κ-HXTXs) are a family of excitotoxic insect-selective neurotoxins from Australian funnel-web spiders that are lethal to a wide range of insects, but display no toxicity towards vertebrates. The prototypic κ-HXTX-Hv1c selectively blocks native and expressed cockroach large-conductance calcium-activated potassium (BKCa or KCa1.1) channels, but not their mammalian orthologs. Despite this potent and selective action on insect KCa1.1 channels, we found that the classical KCa1.1 blockers paxilline, charybdotoxin and iberiotoxin, which all block insect KCa1...
April 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28342090/the-effect-of-varenicline-and-nicotine-patch-on-smoking-rate-and-satisfaction-with-smoking-an-examination-of-the-mechanism-of-action-of-two-pre-quit-pharmacotherapies
#20
Wenying Lu, Kate Chappell, Julia A E Walters, Glenn A Jacobson, Rahul Patel, Natalie Schüz, Stuart G Ferguson
OBJECTIVES: In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation outcomes. The objective of the current study was to test the effects of the pre-quit use of varenicline and nicotine patch on smoking rate and satisfaction with smoking. METHODS: All participants were required to attend up to five study visit sections...
March 24, 2017: Psychopharmacology
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