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https://www.readbyqxmd.com/read/29045967/-early-surgical-treatment-of-multi-segmet-intramedullary-cervical-spinal-cord-ependymoma
#1
C C Ma, G Z Lin, Z Y Wang
OBJECTIVE: To investigate the early clinical treatment and prognosis of multi-segment intramedullary cervical ependymoma. METHODS: Twenty patients with multi-segment (more than 3 segments) intramedullary spinal ependymoma (McCormic grade I) were microsurgically treated with assistance of intraoperative neuroelectrophysiological monitoring. None of them received postoperative radiotherapy. Preoperatively all the patients underwent MRI examination and their neurologically function was assessed by McCormic classification method...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045909/an-integrative-review-of-graduate-transition-programmes-developmental-considerations-for-nursing-management
#2
REVIEW
Shannon Bakon, Judy Craft, Lisa Wirihana, Martin Christensen, Jennie Barr, Lily Tsai
Graduate transition programmes have been developed to recruit new nursing staff and facilitate an effective transition from nursing student to Registered Nurse within the clinical environment. Therefore the aim of this paper was to explore the various elements included in nursing graduate transition programmes. An integrative review was undertaken incorporating a strict inclusion criterion, critical appraisal, and thematic analysis of 30 studies. There are numerous transition programmes available yet there remains a lack of transparency regarding their aims/objectives, course content, support timeframe and the type of support provided...
October 10, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29045747/extracorporeal-membrane-oxygenation-support-for-right-ventricular-failure-after-left-ventricular-assist-device-implantation
#3
Julia Riebandt, Thomas Haberl, Dominik Wiedemann, R Moayedifar, Thomas Schloeglhofer, Stéphane Mahr, Kamen Dimitrov, Philipp Angleitner, Guenther Laufer, Daniel Zimpfer
OBJECTIVES: Right ventricular (RV) failure complicating left ventricular assist device implantation is associated with increased mortality. Despite a lack of supporting evidence, venoarterial extracorporeal membrane oxygenation (ECMO) support is increasingly being used as an alternative to traditional temporary RV support. We report our institutional experience with ECMO-facilitated RV support after left ventricular assist device implantation. METHODS: We retrospectively reviewed the concept of temporary ECMO support for perioperative RV failure in 32 consecutive left ventricular assist device (mean age 52 ± 14 years; male 84...
October 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29045650/association-between-race-and-receipt-of-counselling-or-medication-for-smoking-cessation-in-primary-care
#4
Denise R Hooks-Anderson, Joanne Salas, Scott Secrest, Sarah Skiöld-Hanlin, Jeffrey F Scherrer
Background: Previous evidence of race disparities in smoking cessation treatment has been limited to mostly survey studies which increase the potential for recall bias. We examined if African American versus white patients in primary care are less likely to receive any treatment or if race disparities are specific to the type of treatment offered using data pulled from a large electronic health record system. Methods: Medical record data from 3510 white and 2707 African American patients were available from primary care encounters between 2008 and 2015 and was used to define smoking status, cessation treatments (counselling and medication), and covariates...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29045467/the-dose-of-hydroxyethyl-starch-6-130-0-4-for-fluid-therapy-and-the-incidence-of-acute-kidney-injury-after-cardiac-surgery-a-retrospective-matched-study
#5
Mona Momeni, Lompoli Nkoy Ena, Michel Van Dyck, Amine Matta, David Kahn, Dominique Thiry, André Grégoire, Christine Watremez
The safety of hydroxyethyl starches (HES) is still under debate. No studies have compared different dosing regimens of HES in cardiac surgery. We analyzed whether the incidence of Acute Kidney Injury (AKI) differed taking into account a weight-adjusted cumulative dose of HES 6% 130/0.4 for perioperative fluid therapy. This retrospective cohort study included all adult patients undergoing elective or emergency cardiac surgery with or without cardiopulmonary bypass. Exclusion criteria were patients on renal replacement therapy (RRT), cardiac trauma surgery, heart transplantation, patients with ventricular assist devices, subjects who required a surgical revision for bleeding and those whose medical records were incomplete...
2017: PloS One
https://www.readbyqxmd.com/read/29045282/prediction-model-for-wait-times-in-cardiac-transplantation
#6
David L Joyce, Brian D Lahr, Lyle D Joyce, Sudhir S Kushwaha, Richard C Daly
Wait times have increased for patients approved for heart transplants. We reviewed United Network for Organ Sharing (UNOS) data for 14,242 patients listed for isolated heart transplant (2009-2013) to develop a risk score model for timing left ventricular assist device (LVAD) implantation in bridge-to-transplant patients. We used a multivariable Cox proportional hazards regression model with subsequent bootstrap resampling for internal validation to develop a scoring system that combined risk factors, weighted by the corresponding regression coefficients, to define an individual's risk score...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29045281/pharmacokinetics-of-amikacin-in-critical-care-patients-on-extracorporeal-device
#7
Jesus Ruiz-Ramos, Ricardo Gimeno, Francisca Pérez, Paula Ramirez, Esther Villarreal, Monica Gordon, Carlos Vicent, María Remedios Marqués, Álvaro Castellanos-Ortega
In this study, we evaluate the effect of extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (Levitronix) on the pharmacokinetic of amikacin in critically ill patients. Twelve patients with ECMO and three with Levitronix devices who started treatment with amikacin were included. Amikacin pre (Cmax) and post (Cmin) dose serum concentrations were measured during the first 72-96 hours of treatment initiation. Pharmacokinetic parameters were performed by Bayesian adjustment. The median initial dose was 1,000 mg (range: 600-1,400 mg)...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29045277/determinants-of-improvement-in-cardiopulmonary-exercise-testing-after-left-ventricular-assist-device-implantation
#8
Andrew N Rosenbaum, Shannon M Dunlay, Naveen L Pereira, Thomas G Allison, Simon Maltais, John M Stulak, Lyle D Joyce, Sudhir S Kushwaha
Although improvement in cardiac output and hemodynamic parameters is routinely demonstrated in patients implanted with continuous-flow left ventricular assist devices (CF-LVADs), improvement in exercise capacity is inconsistently seen. Our purpose was to determine whether native cardiac factors, LVAD factors, or comorbid factors were associated with lack of improvement. Review of all patients undergoing preimplant cardiopulmonary exercise testing (CPET) and CPET on LVAD therapy at one institution was performed between 2007 and 2014 (n = 49)...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29045247/factors-associated-with-higher-caregiver-burden-among-family-caregivers-of-elderly-cancer-patients-a-systematic-review
#9
Lixia Ge, Siti Zubaidah Mordiffi
BACKGROUND: Caring for elderly cancer patients may cause multidimensional burden on family caregivers. Recognition of factors associated with caregiver burden is important for providing proactive support to caregivers at risk. OBJECTIVE: The aim of this study was to identify factors associated with high caregiver burden among family caregivers of elderly cancer patients. METHODS: A systematic search of 7 electronic databases was conducted from database inception to October 2014...
November 2017: Cancer Nursing
https://www.readbyqxmd.com/read/29045177/outcomes-of-endovascular-management-of-late-vascular-hemorrhage-after-pancreatic-transplant
#10
Shamar J Young, Lindsey Bergren, Ty Dunn, Prashant Shrestha, Kunal Yadav, Nicholas Frank, Raja Kandaswamy, Jafar Golzarian
OBJECTIVE: The aim of this retrospective study is to evaluate the endovascular treatment of hemorrhage in the nonperioperative setting in pancreas transplant recipients. MATERIALS AND METHODS: All angiograms performed between January 1, 1999, and June 1, 2016, to treat hemorrhage after pancreatic transplant at a single large-volume transplant center were reviewed. Fourteen patients who underwent 21 angiograms were identified. The patients' charts were reviewed for clinical indications, technical aspects of the endovascular interventions, outcomes, and complications...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29045160/taxi-driver-speeding-who-when-where-and-how-a-comparative-study-between-shanghai-and-new-york
#11
Yizhe Huang, Daniel Jian Sun, Juanyu Tang
OBJECTIVE: The three objectives of this study are: 1) To identify the driving style characteristics of taxi drivers in Shanghai and NYC using taxi GPS data and make a comparative analysis; 2) To explore the influence of different driving style characteristics on the frequency of speeding (who and how?) 3) To explore the influence of driving style characteristics, road attributes and environmental factors on the speeding rate (when, where and how?) Methods: This study proposes a Driver-Road-Environment Identification (DREI) method to investigate the determinant factors of taxi speeding violations...
October 18, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29045030/drug-delivery-to-the-brain-across-the-blood-brain-barrier-using-nanomaterials
#12
REVIEW
Yung-Hao Tsou, Xue-Qing Zhang, He Zhu, Sahla Syed, Xiaoyang Xu
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood-brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer-based, lipid-based, and inorganic-based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities...
October 16, 2017: Small
https://www.readbyqxmd.com/read/29044982/surface-assisted-self-assembly-strategies-leading-to-supramolecular-hydrogels
#13
Pierre Schaaf, Cécile Vigier-Carrière, Fouzia Boulmedais, Loïc Jierry
Localized molecular self-assembly processes leading to the growth of nanostructures exclusively from the surface of a material is one of the great challenges in surface chemistry. In the last decade, several works have been reported about the ability of modified or unmodified surfaces to manage the self-assembly of low molecular weight hydrogelators (LMWH) resulting in localized supramolecular hydrogel coatings mainly based on nanofiber architectures. This minireview highlights all strategies that emerged recently to initiate and localize LMWH supramolecular hydrogel formation, their related fundamental issues and applications...
October 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29044959/a-general-strategy-assisted-with-dual-reductants-and-dual-protecting-agents-for-preparing-pt-based-alloys-with-high-index-facets-and-excellent-electrocatalytic-performance
#14
Chenglong Luan, Qing-Xiang Zhou, Yao Wang, Yun Xiao, Xiaoping Dai, Xing-Liang Huang, Xin Zhang
Synthesizing noble metallic nanoparticles (NPs) enclosed by high-index facets (HIFs) is challenged as it involves the tuning of growth kinetics, the selective adsorption of certain chemical species, and the epitaxial growth from HIF enclosed seeds. Herein, a simple and general strategy is reported by using dual reduction agents and dual capping agents to prepare Pt-based alloy NPs with HIFs, in which both glycine and poly(vinylpyrrolidone) serve as the reductants and capping agents. Due to the facilely tunable growth/nucleation rates and protecting abilities of the reductants and capping agents, Pt concave nanocube (CNC), binary Pt-Ni CNC, ternary Pt-Mn-Cu CNC, and Pt-Mn-Cu ramiform polyhedron alloy NPs terminated by HIFs as well as other NPs with well-defined morphologies such as Pt-Mn-Cu nanocube and Pt-Mn-Cu nanoflower are obtained with this approach...
October 16, 2017: Small
https://www.readbyqxmd.com/read/29044929/anticancer-activity-of-vmct1-analogs-against-mcf-7-cells
#15
Cibele Nicolaski Pedron, Gislaine Patricia Andrade, Roseli Hiromi Sato, Marcelo Der Torossian Torres, Giselle Cerchiaro, Anderson Orzari Ribeiro, Vani Xavier Oliveira Junior
Antimicrobial peptides are considered promising drug candidates due to their broad range of activity. VmCT1 (Phe-Leu-Gly-Ala-Leu-Trp-Asn-Val-Ala-Lys-Ser-Val-Phe-NH2 ) is an α-helical antimicrobial peptide that was obtained from the Vaejovis mexicanus smithi scorpion venom. Some of its analogs showed to be as antimicrobial as the wild type and they were designed for understanding the influence of physiochemical parameters on antimicrobial and hemolytic activity. Some cationic antimicrobial peptides exhibit anticancer activity so VmCT1 analogs were tested in order to verify the anticancer activity of this family of peptides...
October 17, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29044898/use-of-computed-tomography-and-minimum-intensity-projection-in-the-detection-of-lobar-pneumonia-mimicking-lung-lobe-torsion-in-a-dog
#16
Sang-Kwon Lee, Kyoung-Oh Cho, Mia Madel Alfajaro, Juhwan Lee, Dohyeon Yu, Jihye Choi
A 10-year-old female spayed Dachshund was referred with progressive coughing for 1 month. The dog was tentatively diagnosed with right middle lung torsion based on pleural effusion, vesicular emphysema, abruptly ending bronchus in consolidated right middle lung, and no contrast enhancement of the affected lobe on radiography and computed tomography (CT). There was no evidence of torsion upon thoracotomy, and histological examination confirmed lobar pneumonia. The CT images were reevaluated using minimum intensity projection and revealed normal bronchial courses...
October 16, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29044896/support-vector-machine-for-breast-cancer-classification-using-diffusion-weighted-mri-histogram-features-preliminary-study
#17
Igor Vidić, Liv Egnell, Neil P Jerome, Jose R Teruel, Torill E Sjøbakk, Agnes Østlie, Hans E Fjøsne, Tone F Bathen, Pål Erik Goa
BACKGROUND: Diffusion-weighted MRI (DWI) is currently one of the fastest developing MRI-based techniques in oncology. Histogram properties from model fitting of DWI are useful features for differentiation of lesions, and classification can potentially be improved by machine learning. PURPOSE: To evaluate classification of malignant and benign tumors and breast cancer subtypes using support vector machine (SVM). STUDY TYPE: Prospective. SUBJECTS: Fifty-one patients with benign (n = 23) and malignant (n = 28) breast tumors (26 ER+, whereof six were HER2+)...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29044894/immediate-implant-placement-and-provisionalization-following-tumor-resective-surgery-in-the-midfacial-region-a-case-series
#18
Nelson Fernandes, Jacobus van den Heever, Leanne Sykes
Surgical and prosthodontic restoration of the midfacial region following tumor resection has always posed a considerable challenge, as this area serves crucial functional and esthetic roles. Being diagnosed and subsequently treated for facial tumors can have an immense psychosocial impact on a patient, as the resulting defects are often disfiguring, and lead to an inability to masticate, swallow, and speak clearly. Provision of an immediate facial and dental prosthesis at the time of surgery can limit these side effects and help reduce mental duress on these patients and their families, as well as aid in the process of rehabilitation...
October 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29044842/changing-perspectives-on-the-strategic-use-of-microwave-heating-in-organic-synthesis
#19
REVIEW
Gregory B Dudley, A E Stiegman
This Personal Account describes collaborative investigations into apocryphal microwave effects in organic chemistry. Focused research on microwave-assisted organic synthesis has been fraught with confusion, controversy, and misinformation. Microwave heating is an undoubtedly useful tactic for organic synthesis, but whether or not it can offer strategic advantages remains an open question in the minds of many people. (Ironically, those who do not consider it an open question are split as to whether it has been resolved affirmatively or negatively...
October 18, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29044720/observational-comparative-effectiveness-of-pharmaceutical-treatments-for-obesity-within-the-veterans-health-administration
#20
Ted R Grabarczyk
STUDY OBJECTIVE: To compare the effectiveness of weight-management medications used to assist with weight loss in real-world clinical practice in the Veterans Health Administration (VHA). DESIGN: Retrospective, multicenter, observational cohort study. DATA SOURCE: National VA Corporate Data Warehouse. PATIENTS: A total of 66,035 VA patients aged 18 years or older with a body mass index of 25 kg/m(2) or greater who had an initial fill for a study medication (orlistat [6153 patients], phentermine [304 patients], lorcaserin [298 patients], or phentermine-topiramate extended release [233 patients]) or participation in the VA's MOVE! weight management program with at least three total visits in a clinic coded as a MOVE clinic in the subsequent 24 weeks (59,047 patients) between January 1, 2012 and July 1, 2016...
October 17, 2017: Pharmacotherapy
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