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https://www.readbyqxmd.com/read/28214937/factors-affecting-the-variability-in-the-observed-levels-of-cadmium-in-blood-and-urine-among-former-and-current-smokers-aged-20-64-and-%C3%A2-65years
#1
Ram B Jain
Data from National Health and Nutrition Examination Survey for 1999-2012 were used to evaluate factors that affect observed levels of blood cadmium (BCd) and urine cadmium (UCd) among former and current smokers aged 20-64 and ≥65 years. Adjusted levels (AGM) for BCd and UCd were higher among females as compared to males. The order of AGM for BCd by race/ethnicity for 20-64 years old was non-Hispanic white (NHW) < non-Hispanic black (NHB) and NHW > NHB for ≥65 years old. The order of AGMs for UCd for 20-64-year-old current smokers was NHW > NHB and NHW > NHB for former smokers...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28188580/ucd-school-of-medicine-summer-student-research-awards-ssra-2016
#2
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28183767/draft-genome-sequence-of-arthrobacter-sp-strain-ucd-gka-phylum-actinobacteria
#3
Gregory N Kincheloe, Jonathan A Eisen, David A Coil
Here we present the draft genome of Arthrobacter sp. strain UCD-GKA. The assembly contains 4,930,274 bp in 33 contigs. This strain was isolated from the handle of a weight bar in the UC Davis Activities and Recreation Center.
February 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28170291/evaluating-a-medical-school-s-climate-for-women-s-success-outcomes-for-faculty-recruitment-retention-and-promotion
#4
Amparo C Villablanca, Yueju Li, Laurel A Beckett, Lydia Pleotis Howell
OBJECTIVE: Women are under-represented in academia. Causative factors include challenges of career-family integration. We evaluated factors reflecting institutional culture (promotion, retention, hiring, and biasing language in promotion letters) as part of an intervention to help shift culture and raise awareness of flexibility policies at the University of California, Davis (UCD). MATERIALS AND METHODS: Data on faculty use of family-friendly policies were obtained at baseline, and surveys for policy awareness were conducted pre(2010)/post(2013) an NIH-funded study educational intervention...
February 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28169024/a-sustainable-use-of-ricotta-cheese-whey-for-microbial-biodiesel-production
#5
Eleonora Carota, Silvia Crognale, Alessandro D'Annibale, Anna Maria Gallo, Silvia Rita Stazi, Maurizio Petruccioli
The increasing demand of plant oils for biodiesel production has highlighted the need for alternative strategies based either on non-food crops or agro-industrial wastes that do not compete with food and feed production. In this context, the combined use of wastewater and oleaginous microorganisms could be a valuable production option. Ricotta cheese whey (RCW), one of the major byproducts of the dairy industry, is produced in very high and steadily increasing amounts and, due to its high organic load, its disposal is cost-prohibitive...
February 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28151401/left-ventricular-structure-and-function-in-relation-to-environmental-exposure-to-lead-and-cadmium
#6
Wen-Yi Yang, Zhen-Yu Zhang, Lutgarde Thijs, Nicholas Cauwenberghs, Fang-Fei Wei, Lotte Jacobs, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Tim S Nawrot, Jan A Staessen
BACKGROUND: Experimental studies have demonstrated that lead and cadmium have direct toxic effects on the myocardium, but the few human studies are limited by design, assessment of exposure, and use of heart failure as a late-stage endpoint. METHODS AND RESULTS: In a prospective population study, we studied the association of left ventricular (LV) function with blood lead (BPb) and 24-hour urinary cadmium (UCd). In 179 participants randomly recruited from a Flemish population (50...
February 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28135567/tafro-syndrome-new-subtype-of-idiopathic-multicentric-castleman-disease
#7
REVIEW
Gordan Srkalovic, Inga Marijanovic, Maya B Srkalovic, David C Fajgenbaum
Castleman disease (CD) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. Unicentric CD (UCD) involves a single region of enlarged nodes. Multicentric CD (MCD) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. MCD is further divided into Human Herpes Virus-8 (HHV-8)-associated MCD, which occurs in immunocompromised individuals, and HHV-8-negative/idiopathic MCD (iMCD)...
January 26, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28108211/user-centered-design-improves-the-usability-of-drug-drug-interaction-alerts-experimental-comparison-of-interfaces
#8
Daniel R Luna, Daniel A Rizzato Lede, Carlos M Otero, Marcelo R Risk, Fernán González Bernaldo de Quirós
Clinical Decision Support Systems can alert health professionals about drug interactions when they prescribe medications. The Hospital Italiano de Buenos Aires in Argentina developed an electronic health record with drug-drug interaction alerts, using traditional software engineering techniques and requirements. Despite enhancing the drug-drug interaction knowledge database, the alert override rate of this system was very high. We redesigned the alert system using user-centered design (UCD) and participatory design techniques to enhance the drug-drug interaction alert interface...
January 17, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28100459/clinical-and-pathological-characteristics-of-hiv-and-hhv8-negative-castleman-disease
#9
Li Yu, Meifeng Tu, Jorge Cortes, Zijun Y Xu-Monette, Roberto N Miranda, Jun Zhang, Robert Z Orlowski, Sattva Neelapu, Prajwal C Boddu, Mary A Akosile, Thomas S Uldrick, Robert Yarchoan, L Jeffrey Medeiros, Yong Li, David C Fajgenbaum, Ken H Young
Castleman disease (CD) comprises three poorly-understood lymphoproliferative variants that share several common histopathological features. Unicentric CD (UCD) is localized to a single region of lymph nodes. Multicentric CD (MCD) manifests with systemic inflammatory symptoms and organ dysfunction due to cytokine dysregulation, and involves multiple lymph node regions. Human herpes virus-8 causes MCD (HHV-8-associated MCD) in immunocompromised individuals, such as HIV infected patients. However, greater than 50% MCD cases are HIV and HHV-8 negative, defined as idiopathic (iMCD)...
January 18, 2017: Blood
https://www.readbyqxmd.com/read/28093407/protein-multiple-sequence-alignment-benchmarking-through-secondary-structure-prediction
#10
Quan Le, Fabian Sievers, Desmond G Higgins
MOTIVATION: Multiple sequence alignment (MSA) is commonly used to analyse sets of homologous protein or DNA sequences. This has lead to the development of many methods and packages forMSAover the past 30 years. Being able to compare different methods has been problematic and has relied on gold standard benchmark datasets of 'true' alignments or on MSA simulations. A number of protein benchmark datasets have been produced which rely on a combination of manual alignment and/or automated superposition of protein structures...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28077348/user-centered-design-of-serious-games-for-older-adults-following-3-years-of-experience-with-exergames-for-seniors-a-study-design
#11
Ellen Brox, Stathis Th Konstantinidis, Gunn Evertsen
BACKGROUND: Seniors need sufficient balance and strength to manage in daily life, and sufficient physical activity is required to achieve and maintain these abilities. This can be a challenge, but fun and motivational exergames can be of help. However, most commercial games are not suited for this age group for several reasons. Many usability studies and user-centered design (UCD) protocols have been developed and applied, but to the best of our knowledge none of them are focusing on seniors' use of games for physical activity...
January 11, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/28028481/brain-transcriptomes-of-harbor-seals-demonstrate-gene-expression-patterns-of-animals-undergoing-a-metabolic-disease-and-a-viral-infection
#12
Stephanie M Rosales, Rebecca L Vega Thurber
Diseases of marine mammals can be difficult to diagnose because of their life history and protected status. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators. Additionally, advancements in high-throughput sequencing (HTS) has contributed to the discovery of novel pathogens in marine mammals. In this study, we use a combination of HTS and stranded harbor seals (Phoca vitulina) to better understand a known and unknown brain disease...
2016: PeerJ
https://www.readbyqxmd.com/read/28008366/pervasive-assistive-technology-for-people-with-dementia-a-ucd-case
#13
Julia Rosemary Thorpe, Kristoffer V H Rønn-Andersen, Paulina Bień, Ali Gürcan Özkil, Birgitte Hysse Forchhammer, Anja M Maier
Smart mobile and wearable technology offers exciting opportunities to support people with dementia (PwD). Its ubiquity and popularity could even benefit user adoption - a great challenge for assistive technology (AT) for PwD that calls for user-centred design (UCD) methods. This study describes a user-centred approach to developing and testing AT based on off-the-shelf pervasive technologies. A prototype is created by combining a smartphone, smartwatch and various applications to offer six support features...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27997202/peptigram-a-web-based-application-for-peptidomics-data-visualization
#14
Jean Manguy, Peter Jehl, Eugène T Dillon, Norman E Davey, Denis C Shields, Thérèse A Holton
Tandem mass spectrometry (MS/MS) techniques, developed for protein identification, are increasingly being applied in the field of peptidomics. Using this approach, the set of protein fragments observed in a sample of interest can be determined to gain insights into important biological processes such as signaling and other bioactivities. As the peptidomics era progresses, there is a need for robust and convenient methods to inspect and analyze MS/MS derived data. Here, we present Peptigram, a novel tool dedicated to the visualization and comparison of peptides detected by MS/MS...
December 20, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27979940/draft-genome-sequence-of-enterococcus-faecalis-strain-ucd-pd3
#15
Dana R De Vries, Alexandra L Martin, Holly H Ganz, Jonathan A Eisen, David A Coil
Here, we present the draft genome sequence of Enterococcus faecalis strain UCD-PD3. The assembly contains 2,861,314 bp in 73 contigs. This strain was isolated from a feral domestic cat (Felis catus) anal sac secretion sample, as part of a project on isolating and characterizing the microbes present in feline anal sacs.
December 15, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27956536/factors-associated-with-delays-in-chemotherapy-initiation-among-patients-with-breast-cancer-at-a-comprehensive-cancer-center
#16
Katya Losk, Ines Vaz-Luis, Kristen Camuso, Rafael Batista, Max Lloyd, Mustafa Tukenmez, Mehra Golshan, Nancy U Lin, Craig A Bunnell
BACKGROUND: National guidelines endorse time-dependent quality metrics for breast cancer care. We examined factors associated with delays in chemotherapy initiation at an NCI-Designated Comprehensive Cancer Center. PATIENTS AND METHODS: We identified 523 patients who received postoperative adjuvant chemotherapy between January 2011 and December 2013 at our center. We defined 28 days from last definitive surgery (LDS) to chemotherapy as the target time frame, and an unacceptable delay in chemotherapy initiation (UCD) as greater than 42 days from LDS...
December 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27908535/mortality-profile-of-patients-with-rheumatoid-arthritis-in-france-and-its-change-in-10-years
#17
Jérôme Avouac, Fazia Amrouche, Christophe Meune, Grégoire Rey, André Kahan, Yannick Allanore
OBJECTIVE: To study the mortality profile of patients with rheumatoid arthritis (RA) in France. METHODS: Data were collected between 2000 and 2011 from the French Epidemiological Center for the Medical Causes of Death database; all death certificates from adults that either mentioned RA as an underlying cause of death (UCD) or as an associated cause of death (ACD) were evaluated using multiple-cause-of-death analysis. The different causes of death and their frequency were reported, together with the ratio of observed/expected number of death (O/E ratio) to measure the strength of association between RA listed as an ACD and the corresponding UCD...
October 29, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27834067/novel-pathogenic-variant-c-580c-t-in-the-cps1-gene-in-a-newborn-with-carbamoyl-phosphate-synthetase-1-deficiency-identified-by-whole-exome-sequencing
#18
Rihwa Choi, Hyung Doo Park, Mina Yang, Chang Seok Ki, Soo Youn Lee, Jong Won Kim, Junghan Song, Yun Sil Chang, Won Soon Park
Diagnosis of the urea cycle disorder (USD) carbamoyl-phosphate synthetase 1 (CPS1) deficiency (CPS1D) based on only the measurements of biochemical intermediary metabolites is not sufficient to properly exclude other UCDs with similar symptoms. We report the first Korean CPS1D patient using whole exome sequencing (WES). A four-day-old female neonate presented with respiratory failure due to severe metabolic encephalopathy with hyperammonemia (1,690 μmol/L; reference range, 11.2-48.2 μmol/L). Plasma amino acid analysis revealed markedly elevated levels of alanine (2,923 μmol/L; reference range, 131-710 μmol/L) and glutamine (5,777 μmol/L; reference range, 376-709 μmol/L), whereas that of citrulline was decreased (2 μmol/L; reference range, 10-45 μmol/L)...
January 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27824287/interview-with-david-j-brayden
#19
David J Brayden
David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute. Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research's in vitro pharmacology laboratory in Dublin (1991). At Elan, he became a senior scientist and project manager of several of Elan's joint-venture drug delivery research collaborations with US biotech companies...
November 8, 2016: Therapeutic Delivery
https://www.readbyqxmd.com/read/27822689/factors-affecting-the-variability-in-the-observed-levels-of-urinary-cadmium-among-children-and-nonsmoker-adolescents
#20
Ram B Jain
Data from the National Health and Nutrition Examination Survey for 1999-2012 were used to evaluate factors that affect observed levels of urine cadmium (UCd) among children aged 6-11 years and nonsmoker adolescents aged 12-19 years. Adjusted UCd levels were found to be statistically significantly higher for female nonsmoker adolescents than male nonsmoker adolescents (p < 0.01). Non-Hispanic white (NHW) participants had statistically significantly lower adjusted levels of UCd (<0.01) than non-Hispanic black (NHB) participants for both children (p < 0...
November 7, 2016: Environmental Science and Pollution Research International
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