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https://www.readbyqxmd.com/read/28425170/rheumatoid-arthritis-as-underlying-cause-of-death-in-31-countries-1987-2011-trend-analysis-of-who-mortality-database
#1
Aliasghar A Kiadaliri, David T Felson, Tuhina Neogi, Martin Englund
Objective To examine trends in rheumatoid arthritis (RA) as an underlying cause of death (UCD) in 31 countries across the globe during 1987-2011. Methods Data on mortality and population were collected from the World Health Organization mortality database and the United Nations. Age-standardized mortality rates (ASMR) were calculated by means of direct standardization. We applied joinpoint regression analysis for trend analysis. Between-country disparities were examined using between-country variance, and Gini coefficient...
April 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28408361/design-of-a-mobile-app-for-nutrition-education-trec-lifestyle-and-formative-evaluation-with-families-of-overweight-children
#2
Silvia Gabrielli, Marco Dianti, Rosa Maimone, Marta Betta, Lorena Filippi, Monica Ghezzi, Stefano Forti
BACKGROUND: Nutrition and diet apps represent today a popular area of mobile health (mHealth), offering the possibility of delivering behavior change (BC) interventions for healthy eating and weight management in a scalable and cost-effective way. However, if commercial apps for pediatric weight management fail to retain users because of a lack of theoretical background and evidence-based content, mHealth apps that are more evidence-based are found less engaging and popular among consumers...
April 13, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28403292/semiotics-and-semiology-of-nursing-evaluation-of-undergraduate-students-knowledge-on-procedures
#3
Gabriela de Sousa Martins Melo, Manuela Pinto Tibúrcio, Camylla Cavalcante Soares de Freitas, Quinídia Lúcia Duarte de Almeida Quithé de Vasconcelos, Isabel Karolyne Fernandes Costa, Gilson de Vasconcelos Torres
OBJECTIVE: to assess the knowledge of scholars on Nursing regarding simple hands hygiene (SHH), blood pressure measurement (BP), peripheral venipuncture (PV) with venous catheter and male urethral catheterization delay (UCD) procedures. METHOD: quantitative study carried out between February and May 2014, with 186 undergraduate Nursing students from 5th to 9th period of a public university of Rio Grande do Norte, with application of four questionnaires. One carried out descriptive and analytic analysis...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28401573/is-tocilizumab-a-potential-therapeutic-option-for-refractory-unicentric-castleman-disease
#4
Muhammad Bilal Abid, Rachel Peck, Muhammad Abbas Abid, Wesam Al-Sakkaf, Yuening Zhang, Giles S Dunnill, Konrad Staines, Iara-Maria Sequeiros, Lisa Lowry
Castleman disease is a rare lymphoproliferative disorder with 2 distinctly defined clinical forms. While multicentric Castleman disease (UCD) poses a potential therapeutic challenge, unicentric variant has historically been considered curable with surgical resection. Hence, little is known to guide management of patients with UCD, refractory to surgical resection and combination chemotherapy. We present a case of a patient, negative for HIV and HHV-8, who had an unsuccessful surgical intervention and no response to radiotherapy and chemotherapy...
April 11, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28387819/slimsearch-a-framework-for-proteome-wide-discovery-and-annotation-of-functional-modules-in-intrinsically-disordered-regions
#5
Izabella Krystkowiak, Norman E Davey
The extensive intrinsically disordered regions of higher eukaryotic proteomes contain vast numbers of functional interaction modules known as short linear motifs (SLiMs). Here, we present SLiMSearch, a motif discovery tool that scans a motif consensus, representing the specificity determinants of a motif-binding domain, against a proteome to discover putative novel motif instances. SLiMSearch applies several distinct and complementary approaches exploiting the common properties of SLiMs to predict novel motifs...
April 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28360178/draft-genome-sequences-of-pseudomonas-moraviensis-ucd-kl30-vibrio-ostreicida-ucd-kl16-colwellia-sp-strain-ucd-kl20-shewanella-sp-strain-ucd-kl12-and-shewanella-sp-strain-ucd-kl21-isolated-from-seagrass
#6
Karley M Lujan, Jonathan A Eisen, David A Coil
Here, we present the draft genome sequences for five bacterial strains. These strains were all isolated from seagrass (Zostera marina) collected from Bodega Bay, CA, as a part of an undergraduate research project focused on seagrass-associated microbes.
March 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28336587/draft-genome-sequence-of-propionibacterium-avidum-strain-ucd-pd2-isolated-from-a-feline-anal-sac
#7
Petra A Dahms, Alexandra L Martin, Holly H Ganz, Jonathan A Eisen, David A Coil
Here, we present the draft genome sequence of Propionibacterium (Cutibacterium) avidum strain UCD-PD2. The assembly contains 2,667,287 bp in 51 contigs. The strain was isolated from anal sac secretion samples collected from a feral domestic cat (Felis catus) as part of a larger project to study the microbiology of cats.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28335496/quantitative-analysis-of-the-kshv-transcriptome-following-primary-infection-of-blood-and-lymphatic-endothelial-cells
#8
A Gregory Bruce, Serge Barcy, Terri DiMaio, Emilia Gan, H Jacques Garrigues, Michael Lagunoff, Timothy M Rose
The transcriptome of the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) after primary latent infection of human blood (BEC), lymphatic (LEC) and immortalized (TIME) endothelial cells was analyzed using RNAseq, and compared to long-term latency in BCBL-1 lymphoma cells. Naturally expressed transcripts were obtained without artificial induction, and a comprehensive annotation of the KSHV genome was determined. A set of unique coding sequence (UCDS) features and a process to resolve overlapping transcripts were developed to accurately quantitate transcript levels from specific promoters...
March 19, 2017: Pathogens
https://www.readbyqxmd.com/read/28302489/modelling-urea-cycle-disorder-citrullinemia-type-1-with-disease-specific-ipscs
#9
Elena Yukie Yoshitoshi-Uebayashi, Taro Toyoda, Katsutaro Yasuda, Maki Kotaka, Keiko Nomoto, Keisuke Okita, Kentaro Yasuchika, Shinya Okamoto, Noriyuki Takubo, Toshiya Nishikubo, Tomoyoshi Soga, Shinji Uemoto, Kenji Osafune
Citrullinemia type 1 (CTLN1) is a urea cycle disorder (UCD) caused by mutations of the ASS1 gene, which is responsible for production of the enzyme argininosuccinate synthetase (ASS), and classically presented as life-threatening hyperammonemia in newborns. Therapeutic options are limited, and neurological sequelae may persist. To understand the pathophysiology and find novel treatments, induced pluripotent stem cells (iPSCs) were generated from a CTLN1 patient and differentiated into hepatocyte-like cells (HLCs)...
March 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28281899/targeting-cps1-in-the-treatment-of-carbamoyl-phosphate-synthetase-1-cps1-deficiency-a-urea-cycle-disorder
#10
Carmen Diez-Fernandez, Johannes Häberle
Carbamoyl phosphate synthetase 1 (CPS1) deficiency (CPS1D) is a rare autosomal recessive urea cycle disorder (UCD), which can lead to life-threatening hyperammonemia. Unless promptly treated, it can result in encephalopathy, coma and death, or intellectual disability in surviving patients. Over recent decades, therapies for CPS1D have barely improved leaving the management of these patients largely unchanged. Additionally, in many cases, current management (protein-restriction and supplementation with citrulline and/or arginine and ammonia scavengers) is insufficient for achieving metabolic stability, highlighting the importance of developing alternative therapeutic approaches...
April 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28250137/mortality-from-musculoskeletal-disorders-including-rheumatoid-arthritis-in-southern-sweden-a-multiple-cause-of-death-analysis-1998-2014
#11
Aliasghar A Kiadaliri, Aleksandra Turkiewicz, Martin Englund
OBJECTIVE: To assess mortality related to musculoskeletal (MSK) disorders and rheumatoid arthritis (RA), specifically, among adults (aged ≥ 20 yrs) in southern Sweden using the multiple-cause-of-death approach. METHODS: All death certificates (DC; n = 201,488) from 1998 to 2014 for adults in the region of Skåne were analyzed when mortality from MSK disorders and RA was listed as the underlying and nonunderlying cause of death (UCD/NUCD). Trends in age-standardized mortality rates (ASMR) were evaluated using joinpoint regression, and associated causes were identified by age- and sex-adjusted observed/expected ratios...
March 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28247338/development-and-psychometric-evaluation-of-the-metabqol-1-0-a-quality-of-life-questionnaire-for-paediatric-patients-with-intoxication-type-inborn-errors-of-metabolism
#12
Nina A Zeltner, Matthias R Baumgartner, Aljona Bondarenko, Regina Ensenauer, Daniela Karall, Stefan Kölker, Chris Mühlhausen, Sabine Scholl-Bürgi, Eva Thimm, Julia Quitmann, Peter Burgard, Markus A Landolt, Martina Huemer
INTRODUCTION: This study is part of the "European network and registry for intoxication type metabolic diseases" (E-IMD) project. Intoxication-type inborn errors of metabolism (IT-IEM) such as urea cycle disorders (UCD) and organic acidurias (OA) have a major impact on patients' lives. Patients have to adhere to strict diet and medication and may suffer from metabolic crises and neurocognitive impairment. Disease-specific health-related quality of life (HrQoL) assessment questionnaires are the method of choice to estimate the subjective burden of a disease...
March 1, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28214937/factors-affecting-the-variability-in-the-observed-levels-of-cadmium-in-blood-and-urine-among-former-and-current-smokers-aged-20-64-and-%C3%A2-65years
#13
Ram B Jain
Data from National Health and Nutrition Examination Survey for 1999-2012 were used to evaluate factors that affect observed levels of blood cadmium (BCd) and urine cadmium (UCd) among former and current smokers aged 20-64 and ≥65 years. Adjusted levels (AGM) for BCd and UCd were higher among females as compared to males. The order of AGM for BCd by race/ethnicity for 20-64 years old was non-Hispanic white (NHW) < non-Hispanic black (NHB) and NHW > NHB for ≥65 years old. The order of AGMs for UCd for 20-64-year-old current smokers was NHW > NHB and NHW > NHB for former smokers...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28188580/ucd-school-of-medicine-summer-student-research-awards-ssra-2016
#14
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28183767/draft-genome-sequence-of-arthrobacter-sp-strain-ucd-gka-phylum-actinobacteria
#15
Gregory N Kincheloe, Jonathan A Eisen, David A Coil
Here we present the draft genome of Arthrobacter sp. strain UCD-GKA. The assembly contains 4,930,274 bp in 33 contigs. This strain was isolated from the handle of a weight bar in the UC Davis Activities and Recreation Center.
February 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28170291/evaluating-a-medical-school-s-climate-for-women-s-success-outcomes-for-faculty-recruitment-retention-and-promotion
#16
Amparo C Villablanca, Yueju Li, Laurel A Beckett, Lydia Pleotis Howell
OBJECTIVE: Women are under-represented in academia. Causative factors include challenges of career-family integration. We evaluated factors reflecting institutional culture (promotion, retention, hiring, and biasing language in promotion letters) as part of an intervention to help shift culture and raise awareness of flexibility policies at the University of California, Davis (UCD). MATERIALS AND METHODS: Data on faculty use of family-friendly policies were obtained at baseline, and surveys for policy awareness were conducted pre(2010)/post(2013) an NIH-funded study educational intervention...
February 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28169024/a-sustainable-use-of-ricotta-cheese-whey-for-microbial-biodiesel-production
#17
Eleonora Carota, Silvia Crognale, Alessandro D'Annibale, Anna Maria Gallo, Silvia Rita Stazi, Maurizio Petruccioli
The increasing demand of plant oils for biodiesel production has highlighted the need for alternative strategies based either on non-food crops or agro-industrial wastes that do not compete with food and feed production. In this context, the combined use of wastewater and oleaginous microorganisms could be a valuable production option. Ricotta cheese whey (RCW), one of the major byproducts of the dairy industry, is produced in very high and steadily increasing amounts and, due to its high organic load, its disposal is cost-prohibitive...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28151401/left-ventricular-structure-and-function-in-relation-to-environmental-exposure-to-lead-and-cadmium
#18
Wen-Yi Yang, Zhen-Yu Zhang, Lutgarde Thijs, Nicholas Cauwenberghs, Fang-Fei Wei, Lotte Jacobs, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Tim S Nawrot, Jan A Staessen
BACKGROUND: Experimental studies have demonstrated that lead and cadmium have direct toxic effects on the myocardium, but the few human studies are limited by design, assessment of exposure, and use of heart failure as a late-stage endpoint. METHODS AND RESULTS: In a prospective population study, we studied the association of left ventricular (LV) function with blood lead (BPb) and 24-hour urinary cadmium (UCd). In 179 participants randomly recruited from a Flemish population (50...
February 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28135567/tafro-syndrome-new-subtype-of-idiopathic-multicentric-castleman-disease
#19
REVIEW
Gordan Srkalovic, Inga Marijanovic, Maya B Srkalovic, David C Fajgenbaum
Castleman disease (CD) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. Unicentric CD (UCD) involves a single region of enlarged nodes. Multicentric CD (MCD) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. MCD is further divided into Human Herpes Virus-8 (HHV-8)-associated MCD, which occurs in immunocompromised individuals, and HHV-8-negative/idiopathic MCD (iMCD)...
January 26, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28108211/user-centered-design-improves-the-usability-of-drug-drug-interaction-alerts-experimental-comparison-of-interfaces
#20
Daniel R Luna, Daniel A Rizzato Lede, Carlos M Otero, Marcelo R Risk, Fernán González Bernaldo de Quirós
Clinical Decision Support Systems can alert health professionals about drug interactions when they prescribe medications. The Hospital Italiano de Buenos Aires in Argentina developed an electronic health record with drug-drug interaction alerts, using traditional software engineering techniques and requirements. Despite enhancing the drug-drug interaction knowledge database, the alert override rate of this system was very high. We redesigned the alert system using user-centered design (UCD) and participatory design techniques to enhance the drug-drug interaction alert interface...
January 17, 2017: Journal of Biomedical Informatics
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