Fabiana M de O Hernandez, Marilene O Santos, Gabriela L Venturin, Jaqueline P Bragato, Gabriela T Rebech, Larissa M Melo, Sidnei F Costa, Jéssica H de Freitas, Carlos Eduardo Siqueira, Déborah A Morais, Wellington T de S Júnior, Fernando B Júnior, Flávia L Lopes, Valéria M F de Lima
Canine leishmaniasis (CanL) is a chronic disease caused by Leishmania infantum , and the limitations of the current treatments have encouraged new alternatives, such as the use of immunomodulatory nutrients. The objective of this study was to determine the serum levels of vitamin A (retinol), vitamin D (25(OH)VD3 ), and zinc (Zn) in dogs with CanL and the effect of in vitro supplementation with the respective active forms ATRA, 1,25(OH)2 VD3 , and SZn on spleen leukocyte cultures. Serum retinol, 25(OH)VD3 , and Zn were determined by HPLC, ELISA, and ICP-MS, respectively...
August 31, 2021: Animals: An Open Access Journal From MDPI