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https://www.readbyqxmd.com/read/29775030/-endoscopic-transnasal-approach-for-surgical-treatment-of-skull-base-clival-area-chordomas-report-of-2-cases
#1
J Ma, P Fang, D Wang, Y J Liu
The case 1 performanced submandibular trauma because of the faint Suddenly. There were no obvious abnormality in physical examination. CT result showed that the tumour located in the lower clivus, and the atlas was infringed. MRI imaging showed the tumour located in the both sides of the internal carotid artery, infringed clivus and atlas front, forwarded into the nasal cavity and oral cavity. The case 2 performanced the left nose stuffy and increased gradually, nasopharyngeal mirror showed the left nasal cavity filled with new life...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29735192/heavy-charged-particles-does-improved-precision-and-higher-biological-effectiveness-translate-to-better-outcome-in-patients
#2
REVIEW
Marco Durante, Jürgen Debus
Protons are the most common charged particles used in oncology. Acceleration of heavier ions requires larger accelerators and is more expensive, yet heavy nuclei share the same advantageous dose-depth profile characteristics of protons and have potential additional advantages. These advantages are related to the physical characteristics of the beam, owing to reduced lateral scattering and sharper lateral penumbra. In addition, heavy ions produce an increased biological response. In fact, in the target region heavy ions behave as densely ionizing radiation, which produce distinct biological effects compared to sparsely ionizing x-rays and protons...
April 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29732516/survival-analysis-of-patients-with-spinal-chordomas
#3
Hui-Hui Sun, Xin Hong, Bing Liu, Jia-Qu Cui, Zhao-Ming Zhou, Xin-Hui Xie, Xiao-Tao Wu
This study was aimed to analyze the survival of patients with spinal chordomas. Patients' data in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved and analyzed statistically. There were 765 patients with spinal chordomas between 1974 and 2013. The overall survival did not improve significantly over decades for patients receiving surgery and radiotherapy (SR) (P = 0.221). There were significant differences in overall survival among subgroups of patients receiving surgery (S), radiotherapy (R), and neither S nor R (NSR) (P = 0...
May 7, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29732421/the-top-50-cited-articles-on-chordomas
#4
Tochukwu Ikpeze, Addisu Mesfin
Background: Chordomas are rare malignant primary tumors of the spine. In the mobile spine and sacrum an en-bloc resection is associated with decreased rates of recurrence. Our objective was to identify the top cited articles in chordoma research and to further analyze characteristics of these articles. Methods: In March 2017, we used ISI Web of Science (v5.11, Thomas Reuter, Philadelphia, Pennsylvania, USA) to search for the following key word: "chordoma"...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29725750/characterization-of-the-endolysosomal-system-in-human-chordoma-cell-lines-is-there-a-role-of-lysosomes-in-chemoresistance-of-this-rare-bone-tumor
#5
Dagmar Kolb-Lenz, Robert Fuchs, Birgit Lohberger, Ellen Heitzer, Katharina Meditz, Dominique Pernitsch, Elisabeth Pritz, Andrea Groselj-Strele, Andreas Leithner, Bernadette Liegl-Atzwanger, Beate Rinner
Chordoma is a rare tumor of the bone derived from remnants of the notochord with pronounced chemoresistance. A common feature of the notochord and chordoma cells is distinct vacuolization. Recently, the notochord vacuole was described as a lysosome-related organelle. Since lysosomes are considered as mediators of drug resistance in cancer, we were interested whether they may also play a role in chemoresistance of chordoma. We characterized the lysosomal compartment in chordoma cell lines by cytochemistry, electron microscopy (ELMI) and mutational analysis of genes essential for the physiology of lysosomes...
May 3, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29724767/role-of-the-apparent-diffusion-coefficient-as-a-predictor-of-tumor-progression-in-patients-with-chordoma
#6
T Sasaki, T Moritani, A Belay, A A Capizzano, S P Sato, Y Sato, P Kirby, S Ishitoya, A Oya, M Toda, K Takahashi
BACKGROUND AND PURPOSE: Diffusion-weighted imaging may aid in distinguishing aggressive chordoma from nonaggressive chordoma. This study explores the prognostic role of the apparent diffusion coefficient in chordomas. MATERIALS AND METHODS: Sixteen patients with residual or recurrent chordoma were divided postoperatively into those with an aggressive tumor, defined as a growing tumor having a doubling time of <1 year, and those with a nonaggressive tumor on follow-up MR images...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29724651/clinical-experience-of-intracranial-chordoma-a-systematic-review-and-meta-analysis-of-the-literature
#7
REVIEW
P Leah, A Dower, C Vescovi, M Mulcahy, D Al Khawaja
Chordomas are rare neoplasms of the axial skeleton, with a predilection for the clival region. The lack of data about intracranial chordomas has led to inconsistent reporting of their clinical behavior and management principles. We performed a systematic review and meta-analysis with the aim of reporting on clinical behavior and management in the literature. We performed an electronic search of the MEDLINE, EMBASE, LILACS, Web of Science, Cochrane, and CINAHL databases. We included studies of patients with intracranial chordoma that had undergone surgical management with 5-year data available...
April 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29721355/pituitary-fossa-chondrosarcoma-an-unusual-cause-of-a-sellar-suprasellar-mass-masquerading-as-pituitary-adenoma
#8
Gautam Dutta, Daljit Singh, Hukum Singh, Arvind Kumar Srivastava, Anita Jagetia, Deepashu Sachdeva
Background: Chondrosarcoma is a mesenchymal malignant tumor composed of tumor cells producing cartilage. It is more commonly found in older age group and usually affects the axial skeleton. Intracranial chondrosarcoma is extremely rare, and chondrosarcoma arising from the sellar region are even rarer with only a few cases described in the literature. We report a case of chondrosarcoma mimicking a sellar suprasellar mass with parasellar extension. Case Description: A 22-year old male presented with generalized intermittent headache along with diplopia and diminished visual acuity without any history of sexual dysfunction or galactorrhea...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29702311/initial-experience-with-intraoperative-phosphorous-32-brachytherapy-during-resection-of-malignant-spinal-tumors
#9
Cecilia L Dalle Ore, Christopher P Ames, Stephen T Magill, Vedat Deviren, Manish K Aghi, Darryl Lau
INTRODUCTION: Brachytherapy is a major adjuvant modality for neoplasms, but few have trialed its use for spinal tumors. This study examines perioperative and oncological outcomes of malignant spinal tumor patients who underwent resection with intraoperative phosphorous-32 (P32) brachytherapy. METHODS: Consecutive adult patients who underwent P32 brachytherapy during malignant spinal tumor resection were retrospectively identified from 2014 to 2015. Complications, tumor recurrence, and survival were reviewed...
April 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29701545/letter-to-the-editor-brachyury-as-prognostic-biomarker-in-chordoma
#10
Hua Zhong, Zhihong Zhou, Guo-Hua Lv, Jing Li, Ming-Xiang Zou
No abstract text is available yet for this article.
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29691145/extended-endoscopic-endonasal-surgery-for-clival-chordoma-and-chondrosarcoma-our-experience-in-14-cases
#11
Diego Culebras, Jorge Torales, Luis Alberto Reyes, Luis Zapata, Sergio García, Pedro Roldán, Cristóbal Langdon, Issam Alobid, Joaquim Enseñat
OBJECTIVE: To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery. METHOD: We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team. RESULTS: We had fourteen patients (male/female 2:1), with a mean age of 49years for chordoma and 32 for chondrosarcoma...
April 21, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29685413/a-cavernous-sinus-lesion-clinically-responsive-to-steroids
#12
M W Ruff, I D Carabenciov, D R Johnson, B E Pollock, J E Parisi, J P Klaas
Tolosa Hunt syndrome (THS) is characterized by painful ophthalmoplegia secondary to idiopathic granulomatous inflammation of the cavernous sinus. The characteristic finding on MRI is an enhancing T1 isointense and T2 hypo- or hyperintense cavernous sinus mass lesion, which may result in focal narrowing of the ipsilateral internal carotid artery. Although the incidence is quite rare, it is a common diagnostic consideration in cases that present with multiple cranial neuropathies. However, the differential diagnosis for a unilateral cavernous sinus lesion in adults is broad and includes neoplastic, inflammatory (such as sarcoidosis and immunoglobulin G4-related disease [IgG4-RD]), infectious etiologies (such as syphilis and leprosy), as well as vascular lesions...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29672767/in-reply-cranial-chordoma-a-new-preoperative-grading-system
#13
Harley Brito da Silva, Laligam N Sekhar
No abstract text is available yet for this article.
April 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29672759/letter-cranial-chordoma-a-new-preoperative-grading-system
#14
Ming-Xiang Zou, Fu-Sheng Liu, Guo-Hua Lv, Xiao-Bin Wang, Jing Li
No abstract text is available yet for this article.
April 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29661049/academic-facility-utilization-and-survival-outcomes-in-adult-head-and-neck-sarcomas-an-ncdb-analysis
#15
Richard B Cannon, Patrick S Carpenter, Dustin Boothe, Luke O Buchmann, Jason P Hunt, Shane Lloyd, Ying J Hitchcock, Jeffrey J Houlton, John R Weis, Hailey M Shepherd, Marcus M Monroe
Objectives To investigate clinicopathologic and treatment factors associated with survival in adult head and neck sarcomas in the National Cancer Database (NCDB). To analyze whether treatment settings and therapies received influence survival outcomes and to compare trends in utilization via an aggregated national data set. Study Design Prospectively gathered data. Setting NCDB. Subjects and Methods The study comprised a total of 6944 adult patients treated for a head and neck sarcoma from January 2004 to December 2013...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29660835/pdgfra-mrna-overexpression-is-associated-with-regional-metastasis-and-reduced-survival-in-oral-squamous-cell-carcinoma
#16
Hui Shan Ong, Sandhya Gokavarapu, Zhen Tian, Jiang Li, Qin Xu, Chen Ping Zhang, Wei Cao
BACKGROUND: Platelet-derived growth factor alpha (PDGFRA) is a gene encoding tyrosine kinase receptor and both EGFR and PDGFRA activate tyrosine kinase. The implication of PGFRA in many cancers and its prognostic significance irrespective to EGFR status in spinal chordoma, gliomas and uterine cancers has shown a need for its investigation in oral squamous cell carcinoma (OSCC). We investigated the prognostic value of PDGFRA mRNA expression in OSCC. PATIENTS AND METHODS: The study was conducted in the department of oral maxillofacial surgery-head and neck oncology, at a tertiary hospital...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29649649/aberrant-expression-of-erk-and-hpgd-indicates-radiation-resistance-and-poor-prognosis-for-patients-with-clival-chordomas
#17
Yixuan Zhai, Jiwei Bai, Shuai Wang, Mingxuan Li, Fei Wang, Chuzhong Li, Yazhuo Zhang
OBJECTIVE: We aim to explore the molecular markers of radiosensitivity and prognostic factors in clival chordomas. METHODS: A total of 35 patients were reviewed retrospectively. The mean follow-up interval was 66.37 months (range: 29-106 months). The Kaplan-Meier method was used for survival analysis. Immunohistochemical staining was used to detect the expression level of ERK and HPGD. RESULTS: Total resection (TR) was achieved in 12 cases, subtotal resection (STR) in 12 cases, partial resection (PR) in 11 cases...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29629241/state-of-the-art-imaging-in-human-chordoma-of-the-skull-base
#18
REVIEW
Rene G C Santegoeds, Yasin Temel, Jan C Beckervordersandforth, Jacobus J Van Overbeeke, Christianne M Hoeberigs
Purpose of Review: Chordoma are rare tumours of the axial skeleton which occur most often at the base of the skull and in the sacrum. Although chordoma are generally slow-growing lesions, the recurrence rate is high and the location makes it often difficult to treat. Both computed tomography (CT) and magnetic resonance imaging (MRI) are crucial in the initial diagnosis, treatment planning and post-treatment follow-up. Recent Findings: Basic MRI and CT characteristics of chordoma were described in the late 1980s and early 1990s...
2018: Current Radiology Reports
https://www.readbyqxmd.com/read/29625617/analysis-of-prognostic-factors-for-survival-in-patients-with-primary-spinal-chordoma-using-the-seer-registry-from-1973-to-2014
#19
Yue Pan, Lingyun Lu, Junquan Chen, Yong Zhong, Zhehao Dai
BACKGROUND: Spinal chordomas are rare primary osseous tumors that arise from the remnants of the notochord. They are commonly considered slow-growing, locally invasive neoplasms with little tendency to metastasize, but the high recurrent rate of spinal chordomas may seriously affect the survival rate and quality of life of patients. The aim of the study is to describe the epidemiological data and determine the prognostic factors for decreased survival in patients with primary spinal chordoma...
April 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29623728/poorly-differentiated-chordomas-showing-loss-of-ini1-smarcb1-a-report-of-2-rare-cases-with-diagnostic-implications
#20
Bharat Rekhi, Kemal Kosemehmetoglu, Swapnil Rane, Figen Soylemezoglu, Elif Bulut
Poorly differentiated chordomas are rare musculoskeletal tumors. Case 1. A 42-year-old lady presented with quadriparesis of 2 months' duration. Radiologic imaging disclosed a soft tissue mass in her left prevertebral- and paravertebral cervical region. Case 2. A 4-year-old male child presented with neck pain and restricted head movements of 1-year duration. Radiologic imaging revealed a contrast enhancing, paraspinal soft tissue mass in his cervical region. Microscopic examination in both the cases revealed a cellular malignant tumor composed of moderate to markedly pleomorphic cells with interspersed mitotic figures, along with focal myxoid change and necrosis...
April 1, 2018: International Journal of Surgical Pathology
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