keyword
https://read.qxmd.com/read/38546282/paediatric-endoscopic-endonasal-middle-skull-base-reconstruction-retrospective-analysis-of-78-patients-treated-in-a-single-tertiary-care-paediatric-center
#1
JOURNAL ARTICLE
Danilo Di Giorgio, Filippo Giovannetti, Paolo Priore, Mirko Scagnet, Federico Mussa, Ingrid Raponi, Valentino Valentini, Lorenzo Genitori
INTRODUCTION: Skull base pathologies in the paediatric population are rare and require treatment by multiple qualified specialists. The endoscopic endonasal approach has revolutionized surgical treatment because it is less invasive than existing treatments.The goal of this study was to retrospectively review our experience with the reconstruction of paediatric skull middle base defects and associated complications. MATERIALS AND METHODS: We analysed medical records from patients aged ≤ 18 years who were treated at our centre between 2013 and 2021...
March 28, 2024: British Journal of Neurosurgery
https://read.qxmd.com/read/38545593/sacral-resections-for-primary-sacral-tumor-an-experience-from-a-tertiary-care-cancer-center-in-india
#2
JOURNAL ARTICLE
Manu Paul, Bhaskar Subin Sugath, Arun Peter Mathew, Madhu Muralee, Amrita Balakrishna Rao, Sunil Kumar Thangaraju, Rexeena V Bhargavan, Kurian Cherian, Paul Augustine
Primary sacral tumors are uncommon and sacrectomy is a complex surgical procedure with substantial risk of morbidity. We conducted a retrospective study of patients who had undergone sacral resections for primary sacral tumors between 2010 and 2020. Ten sacral resections including five type 1 sacrectomy (S1 resected), four type 2 (S1 spared), and one type 3 (S3 spared) were performed during the above period. The median age was 47 years and the most common histologic diagnosis was chordoma (50%). The median operating time was 705 min (range 180-960 min) with a median blood loss of 3400 ml (range 500-7000 ml) and a median duration of hospital stay of 13...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38544830/animal-model-considerations-for-chordoma-research-reproducing-the-tumor-microenvironment-in-vivo-with-humanized-mice
#3
REVIEW
Beatrice Campilan, Christian Schroeder, Emilija Sagaityte, Jonathan Arditi, Owen P Leary, Ziya L Gokaslan, Patricia L Zadnik Sullivan, Margot Martinez-Moreno
Animal models have been commonly used in immunotherapy research to study the cell response to external agents and to assess the effectiveness and safety of new therapies. Over the past few decades, immunocompromised (also called immunodeficient) mice allowed researchers to grow human tumor cells without the impact of the host's immune system. However, while this model is very valuable to understand the tumor biology and to understand the underlying mechanism of immunotherapy, the results may not always directly translate to humans...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38544468/speech-and-swallowing-outcomes-of-surgically-managed-cervical-chordoma-a-case-series
#4
JOURNAL ARTICLE
Alice C Yu, Myungjun Ko, Albert Y Han, Maie St John, Dinesh K Chhetri
OBJECTIVES: Cervical chordoma is a rare, low-grade primary bone tumor occurring in the axial skeleton. Due to challenges in surgical exposure caused by anatomic location, patients may experience dysfunction in speech and swallowing. The objective of this study was to characterize speech and swallowing outcomes for patients undergoing surgical resection of cervical chordoma. Moreover, we detail in-depth two cases with similar initial presentations to compare prognostic factors and management strategies...
March 28, 2024: Laryngoscope
https://read.qxmd.com/read/38539641/clivus-cervical-stabilization-through-transoral-approach-in-patients-with-craniocervical-tumor-three-cases-and-surgical-technical-note
#5
JOURNAL ARTICLE
Gervith Reyes-Soto, Alfonso Corona De la Torre, Kaori Guadalupe Honda Partida, Renat Nurmukhametov, Manuel De Jesus Encarnacion Ramirez, Nicola Montemurro
Craniocervical tumors lead to cervical pain, instability, and neurological symptoms, reducing the quality of life. Effective surgical intervention at the craniocervical junction (CCJ) is critical and complex, involving comprehensive approaches and advanced reconstructive techniques. This study, conducted at Mexico City's National Institute of Cancerology, focused on three surgical cases that occurred in 2023 involving tumors at the CCJ: two chordomas and one prostate adenocarcinoma. We utilized a specialized technique: clivus-cervical stabilization reinforced with a polymethylmethacrylate (PMMA)-filled cervical mesh...
March 5, 2024: Brain Sciences
https://read.qxmd.com/read/38537982/effectiveness-of-carbon-ion-radiotherapy-for-bone-and-soft-tissue-sarcoma-in-older-patients
#6
JOURNAL ARTICLE
Hideyuki Kinoshita, Tsukasa Yonemoto, Shigeru Yamada, Reiko Imai
BACKGROUND/AIM: The aging population is expected to increase the occurrences of bone sarcoma (BS) and soft tissue sarcoma (STS). Carbon ion radiotherapy (CIRT) is reported to be effective for BS and several STSs. However, the effect of CIRT on clinical outcomes, functional prognoses, and quality of life (QOL) in older patients who underwent CIRT has not been reported. Therefore, we aimed to evaluate the effect of CIRT on clinical outcomes, functional prognoses and QOL in older patients with BS or STS...
April 2024: Anticancer Research
https://read.qxmd.com/read/38532359/sirt5-promote-malignant-advancement-of-chordoma-by-regulating-the-desuccinylation-of-c-myc
#7
JOURNAL ARTICLE
Minghui Jiang, Zheng Huang, Li Chen, Ting Deng, Junpeng Liu, Yue Wu
Chordoma is a relatively rare and locally aggressive malignant tumor. Sirtuin (SIRT)5 plays pivotal roles in various tumors, but the role of SIRT5 in chordoma has not been found. This study was performed to investigate the regulatory effects of SIRT5 on cell proliferation, migration, and invasion and the underlying mechanism in chordoma. A xenograft tumor mouse model was established to assess tumor growth. Reverse transcription-quantitative polymerase chain reaction was used to analyze the mRNA levels of SIRT5 and c-myc...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532352/complications-and-local-recurrence-of-chondrosarcoma-and-chordoma-treated-by-total-tumor-resection-in-thoracic-and-lumbar-spine
#8
JOURNAL ARTICLE
Jiacheng Liu, Panpan Hu, Zhongjun Liu, Feng Wei
BACKGROUND: En bloc resection of spinal tumors is challenging and associated with a high incidence of complications; however, it offers the potential to reduce the risk of recurrence when a wide margin is achieved. This research aims to investigate the safety and efficacy of en bloc resection in treating thoracic and lumbar chondrosarcoma/chordoma. METHODS: Data from patients diagnosed with chondrosarcoma and chordoma in the thoracic or lumbar region, who underwent total en bloc or piecemeal resection at our institution over a 7-year period, were collected and regularly followed up...
March 26, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38518293/retraction-immunohistochemical-markers-predicting-recurrence-following-resection-and-radiotherapy-in-chordoma-patients-insights-from-a-multicenter-study
#9
Carlos Pinheiro Neto, Mohamad Bydon
No abstract text is available yet for this article.
March 22, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38501158/proton-beam-therapy-for-clival-chordoma-optimising-rare-cancer-treatments-in-australia
#10
REVIEW
Ashwathy Mathew, Peter Gorayski, Nicholas Candy, Frank Saran, Hien Le
With the anticipated launch of the Australian Bragg Centre for Proton Therapy and Research (ABCPTR) in Adelaide, Australia, proton therapy will become a significant addition to existing cancer treatment options for Australians. The anticipated benefits will be particularly evident in rare cancers such as clival chordomas, a challenging tumour entity due to the anatomical relationship with critical structures, and proven radio-resistance to conventional radiation therapy. The article synthesises key findings from major studies and evaluates the current evidence supporting various management strategies for clival chordomas...
March 19, 2024: Journal of Medical Radiation Sciences
https://read.qxmd.com/read/38481587/chordoma-of-the-oropharynx
#11
Almedina Ramas, Merima Kasumovic, Sabrina Uscupsic, Majda Mujic, Lejla Tokic
BACKGROUND: Chordoma is a rare malignant neoplasm that predominantly arises from the axial skeleton, but can also develop in unusual locations. However, there are also rare cases of "NOS" chordoma involving the oropharyx and epithelial-myoepithelial carcinoma of the parotid gland in the same patient. According to contemporary research, chordoma is a rare malignant neoplasm that arises from the embryonic remnants of the notochord. and typically involves the clivus, sacrococcygeal bones or vertebrae...
2024: Medical Archives
https://read.qxmd.com/read/38476413/surgical-seeding-of-a-chordoma-into-the-temporal-muscle
#12
JOURNAL ARTICLE
Arthur Hosmann, Basant K Misra
No abstract text is available yet for this article.
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38473334/clinical-outcome-after-surgical-treatment-of-sacral-chordomas-a-single-center-retrospective-cohort-of-27-patients
#13
JOURNAL ARTICLE
Stavros Goumenos, Georgios Kakouratos, Ioannis Trikoupis, Panagiotis Gavriil, Pavlos Gerasimidis, Konstantinos Soultanis, Pavlos Patapis, Vasileios Kontogeorgakos, Panayiotis Papagelopoulos
Introduction: The aims of our study were (1) to determine disease-specific and disease-free survival after the en-bloc resection of sacral chordomas and (2) to investigate potential risk factors for tumor recurrence and major postoperative wound-related complications. Methods: We retrospectively analyzed 27 consecutive patients with sacral chordomas who were surgically treated in our institution between 2004 and 2022. Three patients (11.1%) had a recurrent tumor and four patients (14.8%) had history of a second primary solid tumor prior to or after their sacral chordoma...
February 28, 2024: Cancers
https://read.qxmd.com/read/38454495/organelle-resolved-proteomics-uncovers-pla2r1-as-a-novel-cell-surface-marker-required-for-chordoma-growth
#14
JOURNAL ARTICLE
Shahbaz Khan, Jeffrey A Zuccato, Vladimir Ignatchenko, Olivia Singh, Meinusha Govindarajan, Matthew Waas, Salvador Mejia-Guerrero, Andrew Gao, Gelareh Zadeh, Thomas Kislinger
Chordomas are clinically aggressive tumors with a high rate of disease progression despite maximal therapy. Given the limited therapeutic options available, there remains an urgent need for the development of novel therapies to improve clinical outcomes. Cell surface proteins are attractive therapeutic targets yet are challenging to profile with common methods. Four chordoma cell lines were analyzed by quantitative proteomics using a differential ultracentrifugation organellar fractionation approach. A subtractive proteomics strategy was applied to select proteins that are plasma membrane enriched...
March 7, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38451390/unfolding-the-art-of-methodical-approach-for-total-sacrectomy
#15
JOURNAL ARTICLE
Supakool Jearanai, Songphol Malakorn
BACKGROUND: Total sacrectomy is a technically demanding surgery with substantial risks, including high morbidity and mortality due to the likelihood of exsanguination.1-3 Despite the evolution of surgical techniques,4,5 the incidence of postoperative complications remains significant.1 This study presents a systematic approach to total sacrectomy, with a particular focus on a modified technique for isolating the iliac vessels, aimed at effective management of complex sacrococcygeal masses and the reduction of operative complications...
March 7, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38449582/investigating-the-effects-of-chordoma-cell-derived-exosomes-on-the-tumorigenicity-of-nucleus-pulposus-cells
#16
JOURNAL ARTICLE
Esra Aydemir, Nur Zübeyda Yılmaz, Ömer Faruk Bayrak, Fikrettin Sahin
Objective  Interaction of tumor cells with the surrounding environment is essential for tumor growth and progression that eventually leads to metastasis. Growing evidence shows that extracellular vesicles also known as exosomes play a crucial role in signaling between the tumor and its microenvironment. Tumor-derived exosomes have generally protumorigenic effects such as metastasis, hypoxia, angiogenesis, and epithelial-mesenchymal transition. Methods  In this study, exosomes were isolated from a chordoma cell line, MUG-Chor1, and characterized subsequently...
April 2024: Journal of Neurological Surgery. Part B, Skull Base
https://read.qxmd.com/read/38419802/effects-of-nuclear-interaction-corrections-and-trichrome-fragment-spectra-modelling-on-dose-and-linear-energy-transfer-distributions-in-carbon-ion-radiotherapy
#17
JOURNAL ARTICLE
Alessia Bazani, Jacob Brunner, Stefania Russo, Antonio Carlino, Daniel Simon Colomar, Walter Ikegami Andersson, Mario Ciocca, Markus Stock, Piero Fossati, Ester Orlandi, Lars Glimelius, Silvia Molinelli, Barbara Knäusl
BACKGROUND AND PURPOSE: Nuclear interaction correction (NIC) and trichrome fragment spectra modelling improve relative biological effectiveness-weighted dose (DRBE ) and dose-averaged linear energy transfer (LETd ) calculation for carbon ions. The effect of those novel approaches on the clinical dose and LET distributions was investigated. MATERIALS AND METHODS: The effect of the NIC and trichrome algorithm was assessed, creating single beam plans for a virtual water phantom with standard settings and NIC + trichrome corrections...
January 2024: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38417394/soft-tissue-reconstruction-with-pedicled-vertical-rectus-abdominis-myocutaneous-flap-after-total-or-high-sacrectomy-for-giant-sacral-tumor
#18
JOURNAL ARTICLE
Wending Huang, Xianglin Hu, Weiluo Cai, Mo Cheng, Meng Fang, Zhengwang Sun, Tu Hu, Wangjun Yan
BACKGROUND: The large soft-tissue defect after total or high sacrectomy for giant sacral tumor induces high incidence of wound complications. It remains a huge challenge to reconstruct the soft-tissue defect and achieve the preferred clinical outcome. METHODS: A total of 27 patients undergoing one-stage total or high sacrectomy for giant sacral tumors between 2016 and 2021 in a tertiary university hospital were retrospectively reviewed. Participants were divided into two groups...
February 5, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38407581/evaluation-of-cranial-nerve-involvement-in-chordomas-and-chondrosarcomas-a-retrospective-imaging-study
#19
JOURNAL ARTICLE
Tatsushi Oura, Taro Shimono, Daisuke Horiuchi, Takeo Goto, Hirotaka Takita, Taro Tsukamoto, Hiroyuki Tatekawa, Daiju Ueda, Shu Matsushita, Yasuhito Mitsuyama, Natsuko Atsukawa, Yukio Miki
PURPOSE: Cranial nerve involvement (CNI) influences the treatment strategies and prognosis of head and neck tumors. However, its incidence in skull base chordomas and chondrosarcomas remains to be investigated. This study evaluated the imaging features of chordoma and chondrosarcoma, with a focus on the differences in CNI. METHODS: Forty-two patients (26 and 16 patients with chordomas and chondrosarcomas, respectively) treated at our institution between January 2007 and January 2023 were included in this retrospective study...
February 26, 2024: Neuroradiology
https://read.qxmd.com/read/38400611/single-high-energy-arc-proton-therapy-with-bragg-peak-boost-sharp
#20
JOURNAL ARTICLE
Scott N Penfold, Alexandre M C Santos, Melanie Penfold, Emma Shierlaw, Rosanna Crain
INTRODUCTION: Because of the co-location of critical organs at risk, base of skull tumours require steep dose gradients to achieve the prescribed dosimetric criteria. When available, proton beam therapy (PBT) is often considered a desirable modality for these cases, but in many instances, compromises in target coverage are still required to achieve critical organ at risk (OAR) tolerance doses. A number of techniques have been proposed to further improve the penumbra of PBT. In the current study, we propose a novel, collimator-free treatment planning technique that combines high-energy shoot-through proton beams with conventional Bragg peak spot placement...
February 23, 2024: Journal of Medical Radiation Sciences
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