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https://www.readbyqxmd.com/read/28106524/the-utility-of-3d-printing-for-surgical-planning-and-patient-specific-implant-design-for-complex-spinal-pathologies-case-report
#1
Ralph J Mobbs, Marc Coughlan, Robert Thompson, Chester E Sutterlin, Kevin Phan
OBJECTIVE There has been a recent renewed interest in the use and potential applications of 3D printing in the assistance of surgical planning and the development of personalized prostheses. There have been few reports on the use of 3D printing for implants designed to be used in complex spinal surgery. METHODS The authors report 2 cases in which 3D printing was used for surgical planning as a preoperative mold, and for a custom-designed titanium prosthesis: one patient with a C-1/C-2 chordoma who underwent tumor resection and vertebral reconstruction, and another patient with a custom-designed titanium anterior fusion cage for an unusual congenital spinal deformity...
January 20, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28105164/mir-219-5p-inhibits-proliferation-and-clonogenicity-in-chordoma-cells-and-is-associated-with-tumor-recurrence
#2
Wei Wei, Qiuhang Zhang, Zhenlin Wang, Bo Yan, Yanjun Feng, Pu Li
Chordoma is a rare malignant bone tumor that is usually localized to the skull base, vertebral column and sacrum. The transcription factor brachyury, which is encoded by the T gene, has a critical role in the development and progression of chordoma, although the mechanisms underlying brachyury regulation remain unclear. The aim of the current study was to identify and characterize microRNAs (miRs) that regulate brachyury expression in chordoma. MicroRNAs that target brachyury were predicted using miRanda and TargetScan...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28094431/chordoma-immunohistochemical-analysis-of-brachury
#3
İbrahim Sun, Mustafa Güdük, Bülent Güçyetmez, Özlem Yapicier, M Necmettin Pamir
AIM: Chordomas are rare, slow growing but locally aggressive malignancies of the axial skeleton. Skull base chordomas, due to their intricate anatomical localization pose significant challenges to managing physician. In classical and chondroid chordomas the disease course cannot be reliably determined using only morphological criteria. Brachyury (T Gene) was shown to play a central role in chordoma pathogenesis and several studies have also shown that this gene also caries potential as a prognostic biomarker...
December 12, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28088711/surgery-for-chronic-mesh-infection-occurred-10-years-after-sacrectomy-mesh-resection-and-mesentric-leaf-repair-a-case-report
#4
Makoto Koyama, Yusuke Miyagawa, Yuta Yamamoto, Masato Kitazawa, Akira Suzuki, Satoshi Ishizone, Shinichi Miyagawa
INTRODUCTION: Sacrectomy to treat malignant tumors is often results in large pelvic defects to require reconstruction, using a prosthetic mesh. Importance is to avoid its direct contact of mesh with intestine to prevent adhesion between them. PRESENTATION OF CASE: An 83-year old woman who was diagnosed with a mesh infection caused by a small bowel penetration 10 years after sacrectomy combined with mesh reconstruction for chordoma. In the first operation, because of incomplete re-peritonealization due to a large defect in the retroperitoneum, a mesh unavoidably was compelled to contact with the small intestine...
October 26, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28064345/osseous-metastases-of-chordoma-imaging-and-clinical-findings
#5
Connie Chang, Ivan Chebib, Martin Torriani, Miriam Bredella
PURPOSE: To describe the imaging and clinical characteristics of chordoma osseous metastases (COM). MATERIALS AND METHODS: Our study was IRB approved and HIPAA compliant. A retrospective search of our pathology database for pathology-proven COM yielded 15 patients who had undergone MRI, CT, bone scan, and/or FDG-PET/CT. The imaging and clinical features of the COMs were recorded. A control group of age and gender matched chordoma patients without osseous metastasis was evaluated...
January 7, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28060123/whole-body-mri-virtual-autopsy-using-diffusion-weighted-imaging-with-background-suppression-dwibs-at-3-t-in-a-child-succumbing-to-chordoma
#6
Savvas Andronikou, Marnie L Kemp, Michelle Meiring
BACKGROUND: We report the use of diffusion-weighted imaging with background suppression (DWIBS) in pediatric virtual magnetic resonance imaging (MRI) autopsy of a child who succumbed to chordoma. CASE DESCRIPTION: A 10-year-old girl who succumbed to relapse of a chordoma underwent whole-body virtual MRI autopsy 12 hours postmortem with short Tau inversion recovery (STIR) and DWIBS on 3 T, which demonstrated the primary mass, local and cardiac invasion, and metastatic disease to the thorax, abdomen, head/neck, and musculoskeletal system...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28059654/clinical-features-and-surgical-outcomes-of-patients-with-skull-base-chordoma-a-retrospective-analysis-of-238-patients
#7
Liang Wang, Zhen Wu, Kaibing Tian, Ke Wang, Da Li, Junpeng Ma, Guijun Jia, Liwei Zhang, Junting Zhang
OBJECTIVE Skull base chordoma is relatively rare, and a limited number of reports have been published regarding its clinical features. Moreover, the factors associated with extent of resection, as well as the value of marginal resection for long-term survival, are still in question for this disease. The objective of this study was to investigate these factors by evaluating their clinical features and surgical outcomes. METHODS A retrospective analysis of 238 patients with skull base chordomas, who met the inclusion criteria, was performed...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28056253/-updates-and-interpretations-of-2017-nccn-guidelines-for-bone-cancer
#8
X H Niu
The NCCN guidelines for bone cancer are generally updated 1-2 times one year, the contents include diagnosis, treatment guidelines and the latest developments. The latest version of 2017 guideline of bone cancer is released recently. It includes multidisciplinary treatment of common primary bone cancer including diagnosis, surgery, drugs and radiotherapy. It covers osteosarcoma, chondrosarcoma, Ewing's sarcoma, giant cell tumor of bone and chordoma. In this article, the core contents and the updates are illustrated...
January 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28048225/th-cd-209-09-quickly-identifying-good-candidates-for-proton-therapy-from-geometric-considerations
#9
D Hall, A Trofimov, B Winey, N Liebsch, H Paganetti
PURPOSE: We developed a knowledge-based model that can predict the patient-specific benefits of proton therapy based upon geometric considerations. The model could also aid patient selection in model-based clinical trials or help justify clinical decisions to insurance companies. METHODS: The knowledge-based method trains a model upon existing proton treatment plans, exploiting correlations between dose and distance-to-target. Each OAR is split into concentric subvolumes surrounding the target volume, and a skew-normal PDF is fit to the dose distribution found within each shell...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047948/su-f-t-203-high-dose-definitive-proton-therapy-with-integrated-boost-to-hypoxic-subvolumes-determined-by-18f-fluoromisonidazole-fmiso-pet-ct-for-patients-with-recurrent-chordomas-using-intensity-modulated-proton-therapy-impt
#10
S Yan, G Broussard, K De, Amorim Bernstein, Y Wang
PURPOSE: Recurrent chordomas are difficult to control locally. This dosimetric study investigates the feasibility of dose escalation to hypoxic regions, visualized on FMISO-PET, while respecting the dose constraints to the neighboring normal tissues/organs. We propose to deliver a higher dose to the areas of hypoxia (84.5Gy) using IMPT with the goal of improving local control. METHODS: We currently have four patients with hypoxic subvolumes (HSV) greater than 10cc from the FMISO-PET image...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047469/th-cd-209-06-let-based-adjustment-of-impt-plans-using-prioritized-optimization
#11
J Unkelbach, P Botas, N Qin, X Jia, D Giantsoudi, H Paganetti
PURPOSE: In-vitro experiments suggest an increase in proton relative biological effectiveness (RBE) towards the end of range. However, proton treatment planning and dose reporting for clinical outcome assessment has been based on physical dose and constant RBE. Therefore, treatment planning for intensity-modulated proton therapy (IMPT) is unlikely to transition radically to pure RBE-based planning. We suggest a hybrid approach where treatment plans are initially created based on physical dose constraints and prescriptions, and are subsequently altered to avoid high linear energy transfer (LET) in critical structures while limiting the degradation of the physical dose distribution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047315/su-f-t-124-radiation-biological-equivalent-presentations-oflem-1-and-mkm-approaches-in-the-carbon-ion-radiotherapy
#12
W Hsi, G Jiang, Y Sheng
PURPOSE: To study the correlations of the radiation biological equivalent doses (BED) along depth and lateral distance between LEM-1 and MKM approaches. METHODS: In NIRS-MKM (Microdosimetric Kinetic Model) approach, the prescribed BED, referred as C-Eq, doses aims to present the relative biological effectiveness (RBE) for different energies of carbon-ions on a fixed 10% survival value of HCG cell with respect to convention X-ray. Instead of a fixed 10% survival, the BED doses of LEM-1 (Local Effect Model) approach, referred as X-Eq, aims to present the RBE over the whole survival curve of chordoma-like cell with alpha/beta ratio of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046622/su-f-t-214-re-thinking-the-useful-clinical-beam-energy-in-proton-therapy-an-opportunity-for-cost-reduction
#13
El H Bentefour, H Lu
PURPOSE: We conducted a retrospective study of the useful clinical proton beam energy based on the beam range data of patients treated over the last 10 years at Massachusetts General Hospital Proton Therapy Center. METHODS: Treatment field information were collected for all patients treated over the last 10 years (2005-2015) in the two gantry treatment rooms at MGH. The beam ranges for these fields were retrieved and categorized per treatment site. The 10 prostate patients that required the highest beam range (lateral fields) were selected...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046585/su-f-t-221-an-assessment-of-the-potential-for-improved-local-control-of-skull-base-chordomas-via-reduction-of-the-proton-beam-range-uncertainty
#14
L Muller, A Soldner, M Kirk, M Fager, T Solberg, L Robert, D Dolney
PURPOSE: The beam range uncertainty presents a special challenge for proton therapy. Novel technologies currently under development offer strategies to reduce the range uncertainty [1,2]. This work quantifies the potential advantages that could be realized by such a reduction for dosimetrically challenging chordomas at the base of skull. Therapeutic improvement was assessed by evaluating tumor control probabilities (TCP) and normal tissue complication probabilities (NTCP). METHODS: Treatment plans were made for a modulated-scanned proton delivery technique using the Eclipse treatment planning system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046270/su-d-brc-03-development-and-validation-of-an-online-2d-dose-verification-system-for-daily-patient-plan-delivery-accuracy-check
#15
J Zhao, W Hu, Y Xing, X Wu, Y Li
PURPOSE: All plan verification systems for particle therapy are designed to do plan verification before treatment. However, the actual dose distributions during patient treatment are not known. This study develops an online 2D dose verification tool to check the daily dose delivery accuracy. METHODS: A Siemens particle treatment system with a modulated scanning spot beam is used in our center. In order to do online dose verification, we made a program to reconstruct the delivered 2D dose distributions based on the daily treatment log files and depth dose distributions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041320/image-guided-resection-of-aggressive-sacral-tumors
#16
Doniel Drazin, Neil Bhamb, Lutfi T Al-Khouja, Ari D Kappel, Terrence T Kim, J Patrick Johnson, Earl Brien
OBJECTIVE The aim of this study was to identify and discuss operative nuances utilizing image guidance in the surgical management of aggressive sacral tumors. METHODS The authors report on their single-institution, multi-surgeon, retrospective case series involving patients with pathology-proven aggressive sacral tumors treated between 2009 and 2016. They also reviewed the literature to identify articles related to aggressive sacral tumors, their diagnosis, and their surgical treatment and discuss the results together with their own experience...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28041314/spinal-stereotactic-body-radiotherapy-following-intralesional-curettage-with-separation-surgery-for-initial-or-salvage-chordoma-treatment
#17
Dennis T Lockney, Timothy Shub, Benjamin Hopkins, Natalie A Lockney, Nelson Moussazadeh, Eric Lis, Yoshiya Yamada, Adam M Schmitt, Daniel S Higginson, Ilya Laufer, Mark Bilsky
OBJECTIVE Chordoma is a rare malignant tumor for which en bloc resection with wide margins is advocated as primary treatment. Unfortunately, due to anatomical constraints, en bloc resection to achieve wide or marginal margins is not feasible for many patients as the resulting morbidity would be prohibitive. The objective of this study was to evaluate the efficacy of intralesional curettage and separation surgery followed by spinal stereotactic body radiation therapy (SBRT) in patients with chordomas in the mobile spine...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28027905/notochord-isolation-using-laser-capture-microdissection
#18
R G C Santegoeds, Y Yakkioui, A Jahanshahi, G Raven, J J Van Overbeeke, A Herrler, Y Temel
BACKGROUND: Chordoma are malignant tumors of the axial skeleton, which arise from remnants of the notochord. The Notochord (chorda dorsalis) is an essential embryonic structure involved in the development of the nervous system and axial skeleton. Therefore, the notochord seems to be the most appropriate control tissue in chordoma molecular biology research. Nevertheless, up to now mainly different tissues but not the notochord have been used as control for chordoma, due to difficulty of isolating notochordal tissue...
December 24, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#19
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27998723/corrigendum-to-proposal-and-validation-of-a-basic-progression-scoring-system-for-patients-with-skull-base-chordoma-world-neurosurg-91-2016-409-418
#20
(no author information available yet)
No abstract text is available yet for this article.
December 17, 2016: World Neurosurgery
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