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Chordoma

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https://www.readbyqxmd.com/read/28624565/a-case-of-laterally-extended-high-positioned-chordoma-treated-using-the-high-cervical-retropharyngeal-approach
#1
Kiyoshi Ito, Takuya Nakamura, Tatsuro Aoyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo
BACKGROUND: Several surgical approaches for the treatment of pathologies of the craniovertebral junction (CVJ) and high cervical regions have been reported. For the best postoperative results, selection of a surgical route to treat such pathologies should be based on a complete understanding of the approach. CASE DESCRIPTION: Here, we describe the case of a 64-year-old woman who presented with a 5-year history of motor and sensory disturbances in her right upper extremity...
June 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28623412/long-term-follow-up-after-endoscopic-trans-sphenoidal-surgery-or-initial-observation-in-clivus-chordomas
#2
Jon Ramm-Pettersen, Radek Frič, Jon Berg-Johnsen
BACKGROUND: Resection of clivus chordomas through extensive skull base approaches is associated with high mortality and morbidity even in experienced hands. We report our experience with endoscopic trans-sphenoidal surgery, or a "wait-and-scan" strategy in selected patients. METHOD: Ten patients were diagnosed with clivus chordomas during an 8-year period. Six patients underwent primary treatment with endoscopic trans-sphenoidal surgery, followed by adjuvant proton-beam therapy in three of these patients...
June 16, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28606919/expression-and-therapeutic-potential-of-sox9-in-chordoma
#3
Hua Chen, Cassandra Garbutt, Dimitrios Spentzos, Edwin Choy, Francis J Hornicek, Zhenfeng Duan
Conventional chemotherapeutic agents are ineffective in the treatment of chordoma. We investigated the functional roles and therapeutic relevance of the sex-determining region Y (SRY)-box 9 (SOX9) in chordoma. <br /><br />Experimental Design: <p>SOX9 expression was examined by immunohistochemistry (IHC) using 50 chordoma tissue samples. SOX9 expression in chordoma cell lines was examined by Western blot and immunofluorescence assays. We used synthetic human SOX9 siRNA to inhibit the expression of SOX9...
June 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28606578/a-case-of-ecchordosis-physaliphora-in-the-prepontine-cistern-a-rare-entity-in-the-differential-diagnosis-of-an-epidermoid-cyst
#4
Kenji Miki, Koji Yoshimoto, Ataru Nishimura, Satoshi O Suzuki, Akio Hiwatashi, Koji Iihara
BACKGROUND: Ecchordosis physaliphora (EP) is a benign notochordal remnant, which is usually asymptomatic. Herein, we report a case of symptomatic large EP mimicking an epidermoid cyst. CASE DESCRIPTION: A 44-year-old female presented with right facial dysesthesia. Brain magnetic resonance imaging (MRI) showed a mass with a diameter of 3.2 cm that was hypointense on T1-weighted images (T1WI), hyperintense on T2-weighted images (T2WI), iso-to-hyperintense on diffusion-weighted (DW) images, and hyperintense on apparent diffusion coefficient (ADC) map (1...
June 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28598292/effects-of-primary-and-recurrent-sacral-chordoma-on-the-motor-and-nociceptive-function-of-hindlimbs-in-rats-an-orthotopic-spine-model
#5
Rachel Sarabia-Estrada, Alejandro Ruiz-Valls, Sagar R Shah, A Karim Ahmed, Alvaro A Ordonez, Fausto J Rodriguez, Hugo Guerrero-Cazares, Ismael Jimenez-Estrada, Esteban Velarde, Betty Tyler, Yuxin Li, Neil A Phillips, C Rory Goodwin, Rory J Petteys, Sanjay K Jain, Gary L Gallia, Ziya L Gokaslan, Alfredo Quinones-Hinojosa, Daniel M Sciubba
OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and radiotherapy and has high local recurrence rates after resection. Currently, there are no rodent models of spinal chordoma. In the present study, the authors sought to develop and characterize an orthotopic model of human chordoma in an immunocompromised rat. METHODS Thirty-four immunocompromised rats were randomly allocated to 4 study groups; 22 of the 34 rats were engrafted in the lumbar spine with human chordoma...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28595230/-pulmonary-metastasis-of-sacral-chordoma-fifteen-years-after-resection-of-primary-site-report-of-a-case
#6
Tomomi Isono, Hiroyoshi Watanabe, Yumeta Shimazu, Nobuhisa Yamazaki, Hirokazu Tanaka, Masaharu Nakade
A 71-years-old man, who had undergone resection for sacral chordoma 15 years before, was admitted to our hospital to treat a nodule in the right middle lobe detected by computed tomography. The nodule was resected and was histologically diagnosed as lung-metastasis of chordoma.
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28593502/prognostic-factors-in-surgical-patients-with-chordomas-of-the-cervical-spine-a-study-of-52-cases-from-a-single-institution
#7
Hua Zhou, Liang Jiang, Feng Wei, Alexander Joeris, Anahí Hurtado-Chong, Vasiliki Kalampoki, Elke Rometsch, Miao Yu, Fengliang Wu, Lei Dang, Xiaoguang Liu, Zhongjun Liu
BACKGROUND: The recurrence rate of cervical chordomas is high, and hence it is important to discern the prognostic factors for local relapse and overall survival (OS). METHODS: A retrospective review of 52 patients with cervical chordoma operated in our institution from January 1999 to March 2015 was performed. The association of clinicopathologic characteristics with local relapse-free survival (LRFS) and OS was analyzed. Univariate analysis was performed to determine whether tumor characteristics and types of therapy affected prognosis, and a multivariate Cox proportional hazard model was developed to further investigate local recurrence and mortality...
June 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28593113/the-added-value-of-diffusion-magnetic-resonance-imaging-in-the-diagnosis-and-posttreatment-evaluation-of-skull-base-chordomas
#8
Ezgi Guler, Burce Ozgen, Melike Mut, Figen Soylemezoglu, Kader Karli Oguz
Objectives  To determine the use of diffusion-weighted imaging (DWI) in the pre- and posttreatment evaluation of skull base chordomas. Design  Retrospective study. Setting  Tertiary care university hospital. Participants  In total, 17 patients with histopathological diagnosis of chordoma who had magnetic resonance (MR) imaging and DWI were evaluated. Of them, 13 patients had posttreatment MR imaging including DWI. Main Outcome Measures  Three apparent diffusion coefficient (ADC) values were obtained from tumor, and an ADC value was measured from pons for the purpose of normalization...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28593109/extent-of-endoscopic-resection-for-anterior-skull-base-tumors-an-mri-based-volumetric-analysis
#9
Ian J Koszewski, Gregory Avey, Azam Ahmed, Lucas Leonhard, Matthew R Hoffman, Timothy M McCulloch
Objective  To determine the volume of ventral skull base tumor removed following endoscopic endonasal (EEA) resection using MRI-based volumetric analysis and to evaluate the inter-rater reliability of such analysis. Design  Retrospective case series. Setting  Academic tertiary care hospital. Participants  EEA patients November 2012 to August 2015. Main Outcome Measures  Volumetric analysis of pre- and immediately postoperative MR imaging was performed independently by two investigators. The percentage of total tumor resected was evaluated according to resection goal and tumor type...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28591830/letter-factors-predicting-recurrence-after-resection-of-clival-chordoma-using-variable-surgical-approaches-and-radiation-modalities
#10
Ming-Xiang Zou, Guo-Hua Lv, Xiao-Bin Wang, Jing Li
No abstract text is available yet for this article.
June 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28589739/characteristics-and-functional-outcomes-of-chordoma-patients-admitted-for-inpatient-rehabilitation
#11
Sasha E Knowlton, Ross Zafonte, Kevin C O'Connor, Joseph Schwab, Francis Hornicek
PURPOSE: To describe the population and functional changes observed after an inpatient rehabilitation facility stay in chordoma patients Materials and Methods: We conducted a consecutive series retrospective review of patients with chordoma, admitted to an academic inpatient rehabilitation facility after surgical resection from 2010 to 2015. Information regarding demographic, tumor- and surgery-specific data, lengths of stay, complications, admission and discharge functional independence measure scores was collected...
June 7, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28574308/clinical-outcomes-of-an-endoscopic-transclival-and-transpetrosal-approach-for-primary-skull-base-malignancies-involving-the-clivus
#12
Yong Hwy Kim, Chiman Jeon, Young-Bem Se, Sang Duk Hong, Ho Jun Seol, Jung-Ii Lee, Chul-Kee Park, Dong Gyu Kim, Hee-Won Jung, Doo Hee Han, Do-Hyun Nam, Doo-Sik Kong
OBJECTIVE The endoscopic endonasal approach for treating primary skull base malignancies involving the clivus is a formidable task. The authors hypothesized that tumor involvement of nearby critical anatomical structures creates hurdles to endoscopic gross-total resection (GTR). The aim of this study was to retrospectively review the clinical outcomes of patients who underwent an endoscopic endonasal approach to treat primary malignancies involving the clivus and to analyze prognostic factors for GTR. METHODS Between January 2009 and November 2015, 42 patients underwent the endoscopic endonasal approach for resection of primary skull base malignancies involving the clivus at 2 independent institutions...
June 2, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28567186/critical-evaluation-of-contemporary-management-in-a-new-pelvic-exenteration-unit-the-first-25-consecutive-cases
#13
Min Hoe Chew, Yu-Ting Yeh, Ee-Lin Toh, Stephen Aditya Sumarli, Ghee Kheng Chew, Lui Shiong Lee, Mann Hong Tan, Tiffany Priyanthi Hennedige, Shin Yi Ng, Say Kiat Lee, Tze Tec Chong, Hairil Rizal Abdullah, Terence Lin Hon Goh, Mohamed Zulfikar Rasheed, Kok Chai Tan, Choong Leong Tang
AIM: To critically appraise short-term outcomes in patients treated in a new Pelvic Exenteration (PE) Unit. METHODS: This retrospective observational study was conducted by analysing prospectively collected data for the first 25 patients (16 males, 9 females) who underwent PE for advanced pelvic tumours in our PE Unit between January 2012 and October 2016. Data evaluated included age, co-morbidities, American Society of Anesthesiologists (ASA) score, Eastern Cooperative Oncology Group (ECOG) status, preoperative adjuvant treatment, intra-operative blood loss, procedural duration, perioperative adverse event, lengths of intensive care unit (ICU) stay and hospital stay, and oncological outcome...
May 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28531926/in-reply-to-ki-67-index-as-a-prognostic-marker-in-chordomas-a-systematic-review-of-the-literature
#14
Yixuan Zhai, Jiwei Bai, Shuai Wang, Mingxuan Li, Yazhuo Zhang
No abstract text is available yet for this article.
May 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28531925/ki-67-index-as-a-prognostic-marker-in-chordomas-a-systematic-review-of-the-literature
#15
Xiao-Bin Wang, Guo-Hua Lv, Jing Li, Ming-Xiang Zou
No abstract text is available yet for this article.
May 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28527124/erratum-to-symptom-burden-and-life-challenges-reported-by-adult-chordoma-patients-and-their-caregivers
#16
Paula H Song, Hadi Beyhaghi, Josh Sommer, Antonia V Bennett
No abstract text is available yet for this article.
May 19, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28524812/em-proves-invaluable-in-the-confirmation-of-chordoma-in-the-sacral-mass-of-a-middle-aged-man
#17
A Flowers, E Turbat-Herrera
A case of a 47-year-old male with a sacral spine mass was investigated by histology, immunohistochemistry (IHC), and electron microscopy (EM). The light microscopy of the first core biopsy revealed scant cellularity with spindle and round cells with eosinophilic cytoplasm within a fibromyxoid background. Immunostaining with pancytokeratin, cytokeratin 19, and S100 was nonspecific. Another biopsy was attempted to obtain a more definitive diagnosis. Light microscopy of the second core had scant cellular material...
May 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28524794/erratum-um-chor1-establishment-and-characterization-of-the-first-validated-clival-chordoma-cell-line
#18
Mark E P Prince, Xing Fan
No abstract text is available yet for this article.
May 19, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28521059/pediatric-clival-chordoma-a-curable-disease-that-conforms-to-collins-law
#19
Marcio S Rassi, M Maher Hulou, Kaith Almefty, Wenya Linda Bi, Svetlana Pravdenkova, Ian F Dunn, Timothy R Smith, Ossama Al-Mefty
BACKGROUND: Skull base chordomas in children are extremely rare. Their course, management, and outcome have not been defined. OBJECTIVE: To describe the preeminent clinical and radiological features in a series of pediatric patients with skull base chordomas and analyze the outcome of a cohort who underwent uniform treatment. We emphasize predictors of overall survival and progression-free survival, which aligns with Collins' law for embryonal tumors. METHODS: Thirty-one patients with a mean age of 10...
May 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28516081/a-case-of-coincidental-intrasellar-chordoma-and-pituitary-adenoma
#20
Sehoon Park, Hee Sung Kim, Ki-Su Park, Taek-Kyun Nam, Yong-Sook Park, Jeong-Taik Kwon, Kyung-Tae Kim
Although chordomas are midline tumors, primarily intrasellar chordomas are extremely rare. In this report, the authors describe the case of a 68-year-old female with partial abducens nerve palsy in the right eye due to the intrasellar cystic tumor. After endonasal trans-sphenoidal surgery, intraoperative and histopathological findings confirmed the co-occurrence of an entirely intrasellar chordoma and pituitary adenoma. To our knowledge, the present case is the third reported case of an intrasellar chordoma with a pituitary adenoma...
April 2017: Brain Tumor Research and Treatment
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