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https://www.readbyqxmd.com/read/29433161/the-allele-2-of-the-vntr-polymorphism-in-the-gene-that-encodes-a-natural-inhibitor-of-il-1%C3%AE-il-1ra-is-favorably-associated-with-chronic-otitis-media
#1
Maja Živković, Ivana Kolić, Snežana Jesić, Ana Jotić, Aleksandra Stanković
Objectives: Chronic otitis media (COM) is followed by irreversible tissue damage and destruction of the middle ear structures, with the possibility of complications under the maintenance of inflammation. Inflammatory mediators such as cytokines play a crucial role in the initial stage of inflammation. The aim of this study was to evaluate the association of the polymorphisms in two innate immunity/inflammation cascade genes from interleukin-1 (IL-1) gene cluster with COM with regard to cholesteatoma...
February 14, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29424472/characterization-of-a-satellite-dna-in-the-genera%C3%A2-lacerta%C3%A2-and-timon-reptilia-lacertidae-and-its-role-in-the-differentiation-of-the-w-chromosome
#2
Massimo Giovannotti, Paola Nisi Cerioni, Verónica Rojo, Ettore Olmo, Tahar Slimani, Andrea Splendiani, Vincenzo Caputo Barucchi
In this study, IMO-TaqI satDNA, previously isolated in several species of Lacertidae, was isolated and characterized from four species of the genus Lacerta and three of the genus Timon. The aim was to gain further insights into the evolutionary dynamics of this satDNA, its occurrence among lacertids and to understand if it plays any role in sex chromosome evolution in these seven species. The results here obtained highlighted the presence of this repetitive element in the genome of all the species investigated, thus indicating that IMO-TaqI satDNA is evolutionary conserved among a wide variety of lacertids...
February 9, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29391820/relationship-of-vitamin-d-receptor-gene-polymorphisms-in-helicobacter-pylori-gastric-patients
#3
Dinelma de Jesus Martins, Gyselly Cb Matos, Rosane Sp Loiola, Vivian D'Annibale, Tereza Corvelo
Purpose: The present study aimed to investigate the association between the human VDR gene and Helicobacter pylori infection. Patients and methods: A cross-sectional study was conducted on 208 adult patients with upper gastrointestinal symptoms. Gastric biopsy specimens were obtained from each patient for molecular DNA and histological examination. Patients were genotyped for VDR gene polymorphisms using polymerase chain reaction and restriction fragment length polymorphism analysis...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29388852/associations-between-vitamin-d-receptor-polymorphisms-and-susceptibility-to-behcet-s-disease-a-meta-analysis
#4
Zahra Mirfeizi, Samira Tabaei, Yalda Ravanshad, Kamila Hashemzadeh, Elahe Kharazmi, Hassan Mehrad-Majd
BACKGROUND: The vitamin D receptor (VDR) gene polymorphisms have been reported to be related to the development of Behcet's disease (BD). However, the results have been inconsistent among diverse populations. Therefore, this comprehensive meta-analysis has been designed to assess a more accurate association between VDR polymorphisms and BD susceptibility. METHODS: An electronic literature search was conducted to identify eligible studies. Pooled odds ratios (OR) with corresponding 95% confidence interval (CI) were calculated in different genetic models to assess this association...
February 1, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29384117/vitamin-d-receptor-variants-and-uncontrolled-asthma
#5
K Hutchinson, C P Kerley, J Faul, P Greally, D Coghlan, M Louw, B Elnazir, Y Rochev
Background. Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate the association between 2 VDR polymorphisms and uncontrolled paediatric asthma. Methods. 44 asthmatic children and 57 healthy volunteers were studied. The VDR TaqI gene variant in exon 9 (T/C) (rs731236) and ApaI (rs7975232) in intron 8 (C/T) were determined, using TaqMan® Assays. The lung function, serum 25-hydroxyvitamin D (25OHD) levels and other biomarkers of allergy, immunity, airway and systemic inflammation were as-sessed...
November 28, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29372085/distribution-of-trauma-care-facilities-in-oman-in-relation-to-high-incidence-road-traffic-injury-sites-pilot-study
#6
Sara M Al-Kindi, Ahmed A Naiem, Kadhim M Taqi, Najla M Al-Gheiti, Ikhtiyar S Al-Toobi, Nasra Q Al-Busaidi, Ahmed Z Al-Harthy, Alaa M Taqi, Sharif A Ba-Alawi, Hani A Al-Qadhi
Objectives: Road traffic injuries (RTIs) are considered a major public health problem worldwide. In Oman, high numbers of RTIs and RTI-related deaths are frequently registered. This study aimed to evaluate the distribution of trauma care facilities in Oman with regards to their proximity to RTI-prevalent areas. Methods: This descriptive pilot study analysed RTI data recorded in the national Royal Oman Police registry from January to December 2014. The distribution of trauma care facilities was analysed by calculating distances between areas of peak RTI incidence and the closest trauma centre using Google Earth and Google Maps software (Google Inc...
November 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29363636/drug-induced-oral-erythema-multiforme-a-diagnostic-challenge
#7
Syed Ahmed Taqi
Trimethoprim-sulfamethoxazole (cotrimoxazole or TMP/SMX) is commonly used for the treatment of urinary or lower respiratory tract infections. A comprehensive review is presented of the world literature on adverse reactions to TMP/SMX since its first use in 1968, when concern was expressed about possible hematologic toxicity. The adverse reactions to TMP/SMX occur in approximately 1%-3% of persons in general population. Here, we report a case of oral erythema multiforme (EM) secondary to TMP/SMX that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of distinguishing them from other ulcerative disorders involving oral cavity...
January 2018: Annals of African Medicine
https://www.readbyqxmd.com/read/29351807/vitamin-d-receptor-rs2228570-polymorphism-is-associated-with-lh-levels-in-men-exposed-to-anabolic-androgenic-steroids
#8
Linda Björkhem-Bergman, Mikael Lehtihet, Anders Rane, Lena Ekström
OBJECTIVE: The primary aim of this study was to investigate the association between the vitamin D receptor polymorphisms rs2228570 (Fok1) and rs731236 (TaqI) and LH and FSH levels in relation to anabolic androgenic steroid (AAS) use. RESULTS: Two cohorts were analyzed. Cohort 1 comprised healthy volunteers given single supra-physiological doses of 500 mg testosterone (n = 25). Cohort 2 comprised 45 self-reporting AAS users. Healthy volunteers homozygous for the C-allele of the Fok1 polymorphism exhibited 30% higher LH levels than T-carriers at baseline (p = 0...
January 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29331875/the-association-between-vitamin-d-receptor-polymorphisms-and-multiple-sclerosis-in-a-turkish-population
#9
Ozden Kamisli, Ceren Acar, Mert Sozen, Mehmet Tecellioglu, Fatma Ebru Yücel, Dilara Vaizoglu, Cemal Özcan
BACKGROUND: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. METHODS: 167 MS patients and 146 healthy control subjects were included in the present study...
January 9, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29326340/rare-cause-of-pulmonary-cavitation-in-a-75-year-old-man
#10
Jaffar Al-Sheikhli, Hussein Taqi, John Drake, Ayaaz Habib
A 75-year-old man of Asian descent presented to the acute medical unit with signs and symptoms suggestive of a community-acquired pneumonia. He had multiple comorbidities and was relatively immunocompromised as a result. Initial investigations supported the diagnosis of community-acquired pneumonia complicated by a cavitating lung lesion, and the patient was treated as per hospital guidelines. He continued to deteriorate despite appropriate therapy and developed a hydropneumothorax, requiring the insertion of a chest drain...
January 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29320820/first-molecular-characterization-of-hypoderma-actaeon-in-cattle-and-red-deer-cervus-elaphus-in-portugal
#11
Haroon Ahmed, Sérgio Ramalho Sousa, Sami Simsek, Sofia Anastácio, Seyma Gunyakti Kilinc
Hypoderma spp. larvae cause subcutaneous myiasis in several animal species. The objective of the present investigation was to identify and characterize morphologically and molecularly the larvae of Hypoderma spp. collected from cattle (Bos taurus taurus) and red deer (Cervus elaphus) in the district of Castelo Branco, Portugal. For this purpose, a total of 8 larvae were collected from cattle (n=2) and red deer (n=6). After morphological identification of Hypoderma spp. larvae, molecular characterization was based on PCR-RFLP and mitochondrial CO1 gene sequence analysis...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29273706/delayed-diagnosis-of-ureteral-injury-following-penetrating-abdominal-trauma-a-case-report-and-review-of-the-literature
#12
Kadhim M Taqi, Manar Mohammed Nassr, Jihad Salim Al Jufaili, Alla Ibrahim Abu-Qasida, Joseph Mathew, Hani Al-Qadhi
BACKGROUND Ureteral injuries are considered to be uncommon in cases of trauma. The possibility of damage to the ureters may not be considered in the setting of acute trauma when life-threatening injuries take clinical management priority. A case of acute ureteral injury is described in a patient with acute penetrating gunshot abdominal injury that had a delay in diagnosis, with a review of the literature. CASE REPORT A 29-year-old woman presented to our hospital with a missed ureteral injury following a self-inflicted gunshot injury to the abdomen...
December 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29248582/association-between-vitamin-d-receptor-polymorphisms-and-hepatitis-b-virus-infection-susceptibility-a-meta-analysis-study
#13
REVIEW
Qiao He, Yecai Huang, Li Zhang, Yan Yan, Jingyi Liu, Xiaoyu Song, Weixian Chen
BACKGROUND: Hepatitis B virus (HBV) infection is still a serious public health problem. Understanding risk factors associated with development of HBV is greatly important. Numerous studies focus on relationship between vitamin D receptor (VDR) polymorphisms (TaqI, FokI, ApaI, BsmI) and the risk of HBV infection in different ethnic groups. However the results published so far are inconsistent. The aim of this study is to quantify the association between VDR polymorphisms with HBV infection by meta-analysis approach...
December 14, 2017: Gene
https://www.readbyqxmd.com/read/29238479/vitamin-d-receptor-gene-polymorphisms-as-a-risk-factor-for-obesity-in-saudi-men
#14
Ayman Saeed Al-Hazmi, Mazin Mohammed Al-Mehmadi, Sarah Mohammad Al-Bogami, Ashjan Ali Shami, Ahmed Ali Al-Askary, Anas Mohammad Alomery, Saad Saeed Al-Shehri, Haytham Dahlawi, Khadija Abdulrazag, Tariq Ali, Abdalaziz Al-Bogami, Emad Sheshah, Abdalaziz Al-Mutairi, Salh Al-Suhimi, Faris Alharb
Background: The prevalence of obesity and vitamin D deficiency in Saudi Arabia has increased recently. Decreased physical activity might play a role in obesity. Previous studies showed an association between low vitamin D level and its receptor polymorphism with obesity development. Objective: To determine association of low vitamin D level and its receptor polymorphism with obesity in Saudi men. Methods: This case control study was carried out from March 2016 through March 2017...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29230954/association-between-vitamin-d-receptor-polymorphisms-and-systemic-lupus-erythematosus-in-an-indian-cohort
#15
Harishankar Mahto, Rina Tripathy, Bidyut K Das, Aditya K Panda
AIM: Systemic lupus erythematosus (SLE) is an autoimmune disorder with various clinical manifestations. Susceptibility to development of SLE has been linked to several factors, such as genetic, environmental and hormonal. Vitamin D appears to have a regulatory role on disease manifestation and activity. Vitamin D exerts its effect through vitamin D receptors (VDR). Several studies have demonstrated an association between VDR polymorphisms and susceptibility to SLE in different populations, although the results are still inconclusive...
December 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29204386/identification-of-genotypes-and-allelic-frequencies-of-vitamin-d-receptor-gene-polymorphism-taqi-in-egyptian-melasma-patients
#16
Iman Seleit, Ola Ahmed Bakry, Eman Masoud, Shaimaa Nabil
Background: Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in a mask-like distribution. The pathogenesis of melasma is not fully understood. Vitamin D plays a role in skin pigmentation. It exerts its effect through vitamin D receptor (VDR), which is expressed in variable cells including normal melanocytes. Aim and Objective: The aim of the current work was to investigate if VDR gene polymorphism (TaqI) confers susceptibility to melasma in Egyptian patients...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29171558/enhanced-recovery-after-surgery-eras-protocol-in-stoma-reversals
#17
Muhammad Taqi Pirzada, Faisal Naseer, Raza Haider, Jahanzaib Haider, Monis Jaleel Ahmed, Shams Nadeem Alam, Sheeraz Shakoor Siddique
OBJECTIVE: To compare the length of hospital stay and return of bowel movement using the conventional management versus 'enhanced recovery after surgery' protocol. METHODS: This study was conducted at the Civil Hospital, Karachi, from June 2014 to May 2015, and comprised patients undergoing stoma reversal. Patients were randomly allocated in two equal groups, i.e. A (treated with conventional peri-operative management) and B (with 'enhanced recovery after surgery' protocol)...
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29110148/association-between-vdr-polymorphisms-and-multiple-sclerosis-systematic-review-and-updated-meta-analysis-of-case-control-studies
#18
Yan-Jie Zhang, Li Zhang, Shan-Yu Chen, Guo-Jun Yang, Xiao-Lei Huang, Yu Duan, Li-Juan Yang, Dong-Qing Ye, Jing Wang
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in multiple sclerosis (MS). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and MS risk. The aim of the current study was to quantify the magnitude of the association between BsmI, FokI, ApaI, and TaqI VDR polymorphisms and MS risk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search and meta-analysis of the VDR gene polymorphisms and the risk of MS...
November 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29105380/association-study-of-transforming-growth-factor-alpha-taqi-polymorphism-and-the-risk-of-cleft-lip-and-or-palate-in-an-iranian-population
#19
Fahimeh Bagheri, Asghar Ebadifar, Hamid Reza Khorram Khorshid, Koorosh Kamali
BACKGROUND: The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population. METHODS: In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p-value of <0.05 was considered statistically significant. RESULTS: For the TGFA TaqI polymorphism, the distributions of genotypes in the NSCLP (p = 0...
October 16, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29104144/iraqi-propolis-increases-degradation-of-il-1%C3%AE-and-nlrc4-by-autophagy-following-pseudomonas-aeruginosa-infection
#20
Majid S Jabir, Ghassan M Sulaiman, Zainab J Taqi, Dong Li
Autophagy is a cellular process for maintaining cellular homeostasis. This process can be induced by different factors, such as immune stimuli and pathogen-associated molecules. Autophagy has an important role in the control of IL-1β secretion by macrophages and other cell types. In present study, we describe a novel role for Iraqi propolis affecting autophagy in controlling the secretion of IL-1β in bone-marrow macrophages (BMDMs). After infection with Pseudomonas aeruginosa in the presence of propolis, the degradation of IL-1β was induced, and the activity of inflammasome was reduced...
November 8, 2017: Microbes and Infection
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