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https://www.readbyqxmd.com/read/29204386/identification-of-genotypes-and-allelic-frequencies-of-vitamin-d-receptor-gene-polymorphism-taqi-in-egyptian-melasma-patients
#1
Iman Seleit, Ola Ahmed Bakry, Eman Masoud, Shaimaa Nabil
Background: Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in a mask-like distribution. The pathogenesis of melasma is not fully understood. Vitamin D plays a role in skin pigmentation. It exerts its effect through vitamin D receptor (VDR), which is expressed in variable cells including normal melanocytes. Aim and Objective: The aim of the current work was to investigate if VDR gene polymorphism (TaqI) confers susceptibility to melasma in Egyptian patients...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29171558/enhanced-recovery-after-surgery-eras-protocol-in-stoma-reversals
#2
Muhammad Taqi Pirzada, Faisal Naseer, Raza Haider, Jahanzaib Haider, Monis Jaleel Ahmed, Shams Nadeem Alam, Sheeraz Shakoor Siddique
OBJECTIVE: To compare the length of hospital stay and return of bowel movement using the conventional management versus 'enhanced recovery after surgery' protocol. METHODS: This study was conducted at the Civil Hospital, Karachi, from June 2014 to May 2015, and comprised patients undergoing stoma reversal. Patients were randomly allocated in two equal groups, i.e. A (treated with conventional peri-operative management) and B (with 'enhanced recovery after surgery' protocol)...
November 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29110148/association-between-vdr-polymorphisms-and-multiple-sclerosis-systematic-review-and-updated-meta-analysis-of-case-control-studies
#3
Yan-Jie Zhang, Li Zhang, Shan-Yu Chen, Guo-Jun Yang, Xiao-Lei Huang, Yu Duan, Li-Juan Yang, Dong-Qing Ye, Jing Wang
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in multiple sclerosis (MS). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and MS risk. The aim of the current study was to quantify the magnitude of the association between BsmI, FokI, ApaI, and TaqI VDR polymorphisms and MS risk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search and meta-analysis of the VDR gene polymorphisms and the risk of MS...
November 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29105380/association-study-of-transforming-growth-factor-alpha-taqi-polymorphism-and-the-risk-of-cleft-lip-and-or-palate-in-an-iranian-population
#4
Fahimeh Bagheri, Asghar Ebadifar, Hamid Reza Khorram Khorshid, Koorosh Kamali
BACKGROUND: The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population. METHODS: In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p-value of <0.05 was considered statistically significant. RESULTS: For the TGFA TaqI polymorphism, the distributions of genotypes in the NSCLP (p = 0...
October 16, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29104144/iraqi-propolis-increases-degradation-of-il-1%C3%AE-and-nlrc4-by-autophagy-following-pseudomonas-aeruginosa-infection
#5
Majid S Jabir, Ghassan M Sulaiman, Zainab J Taqi, Dong Li
Autophagy is a cellular process for maintaining cellular homeostasis. This process can be induced by different factors, such as immune stimuli and pathogen-associated molecules. Autophagy has an important role in the control of IL-1β secretion by macrophages and other cell types. In present study, we describe a novel role for Iraqi propolis affecting autophagy in controlling the secretion of IL-1β in bone-marrow macrophages (BMDMs). After infection with Pseudomonas aeruginosa in the presence of propolis, the degradation of IL-1β was induced, and the activity of inflammasome was reduced...
November 8, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29099735/effect-of-pharmacogenetic-markers-of-vitamin-d-pathway-on-deferasirox-pharmacokinetics-in-children
#6
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics in a cohort of pediatric patients. PATIENTS AND METHODS: Eighteen children with β-thalassemia were enrolled. Drug plasma concentrations at the end of dosing interval (Ctrough) and after 0, 2, 4, 6, and 24 h of drug administration were measured by a HPLC-UV method...
November 2, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29067071/caries-risk-assessment-in-school-children-using-reduced-cariogram-model
#7
Muhammad Taqi, Ishak Abdul Razak, Norintan Ab-Murat
OBJECTIVE: To estimate the percentage of children with low, moderate and high caries risk; and to determine the predictors of caries risk amongst 11-12 year old Pakistani school children. METHODS: Subjects' caries risk was assessed using the Cariogram programme. The survey was done among school children in Bhakkar district of Punjab, Pakistan. Caries and plaque level were assessed using the DMFT and Sillnes and Loe indices respectively, while diet content and frequency were assessed using a three-day diet diary...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29066872/association-of-vitamin-d-receptor-gene-polymorphisms-with-diabetic-dyslipidemia-in-the-elderly-male-population-in-north-china
#8
Zheng Xia, Yazhuo Hu, Zhitao Han, Ya Gao, Jie Bai, Yao He, Hua Zhao, Honghong Zhang
BACKGROUND: The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China. METHODS: A total of 242 T2DM patients with dyslipidemia (DH group, n=108) or without dyslipidemia (DO group, n=134) and 100 controls were genotyped for ApaI, TaqI and FokI single nucleotide polymorphisms (SNPs) of the VDR gene using polymerase chain reaction-restriction fragment length polymorphism and sequencing...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29063227/implantation-of-right-kidneys-is-the-risk-of-technical-graft-loss-real
#9
Taqi T Khan, Nadeem Ahmad, Kashif Siddique, Konstantinos Fourtounas
BACKGROUND: The left kidney (LK) is preferred by transplant surgeons, because its vein is always of good length and has a thick wall that enables safe suturing. On the other hand, the right renal vein is generally shorter and thinner walled, and well known for its technical difficulty during venous anastomosis, and can result in graft loss. We examined our living (LD) and deceased donor (DD) recipient data and compared the incidence of technical graft loss and early graft function in right and left kidneys...
October 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29043707/congenital-malformations-in-singleton-infants-conceived-by-assisted-reproductive-technologies-and-singleton-infants-by-natural-conception-in-tehran-iran
#10
Ramin Mozafari Kermani, Mansoureh Farhangniya, Seyed Abolhassan Shahzadeh Fazeli, Pezhman Bagheri, Mahnaz Ashrafi, Ahmad Vosough Taqi Dizaj
Background: Multiple pregnancies occur more frequently in assisted reproductive technology (ART) compared to normal conception (NC). It is known that the risk of congenital malformations in a multiple pregnancy are higher than single pregnancy. The aim of this study is to compare congenital malformations in singleton infants conceived by ART to singleton infants conceived naturally. MATERIALS AND METHODS: In this historical cohort study, we performed a historical cohort study of major congenital malformations (MCM) in 820 singleton births from January 2012 to December 2014...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29032145/genetic-association-analysis-of-vitamin-d-receptor-gene-polymorphisms-and-obesity-related-phenotypes
#11
Correa-Rodríguez María, Jose Antonio Carrillo-Ávila, Schmidt-RioValle Jacqueline, González-Jiménez Emilio, Vargas Sofia, Martin Javier, Rueda-Medina Blanca
Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR). The aim of this study was to investigate the contribution of the VDR gene to obesity-related phenotypes in a population of Caucasian young adults. The study population consisted of 701 healthy Spanish young adults (mean age 20.41±2.48). Three single-nucleotide polymorphisms (SNPs) of VDR (TaqI, BsmI and FokI) were selected as genetic markers. Body composition measurements including weight, body mass index (BMI), fat mass (FM), percentage of fat mass (PFM), fat-free mass (FFM) and visceral fat level (VFL) were analysed...
January 15, 2018: Gene
https://www.readbyqxmd.com/read/29022486/association-of-vitamin-d-receptor-gene-polymorphisms-with-breast-cancer-risk-in-an-egyptian-population
#12
Haidan M El-Shorbagy, Nada H Mahmoud, Salwa Sabet
This study aimed to explore whether genetic polymorphisms in vitamin D receptor are correlated to the breast cancer prevalence in an Egyptian population. Polymerase chain reaction-restriction fragment polymorphism was used to genotype three frequently analyzed vitamin D receptor gene single-nucleotide polymorphisms (rs1544410, rs7975232, and rs731236) and were identified by sequencing analysis. This is the first study that recorded a new single-nucleotide polymorphism in ApaI genotype within an Egyptian population and was registered with the accession number KY859868...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29017672/surgical-outcome-of-pancreaticoduodenectomy-in-pancreatic-and-periampullary-neoplasms
#13
Muhammad Fahd Shah, Muhammad Taqi Pirzada, Irfan Ul Islam Nasir, Awais Amjad Malik, Umer Farooq, Abdul Wahid Anwer, Shahid Khattak, Muhammad Aasim Yusuf, Amir Ali Syed, Faisal Hanif
OBJECTIVE: To report the results in the surgical treatment of pancreatic and periampullary neoplasms with emphasis on surgical technique, short-term postoperative outcome and the lessons learnt. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: This study was carried out at Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, from October 2014 to May 2016. METHODOLOGY: Patients undergoing surgical treatment of pancreatic and periampullary neoplasms were selected...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28990310/the-interaction-between-vitamin-d-receptor-polymorphisms-and-sun-exposure-around-time-of-diagnosis-influences-melanoma-survival
#14
Irene Orlow, Yang Shi, Peter A Kanetsky, Nancy E Thomas, Li Luo, Sergio Corrales-Guerrero, Anne E Cust, Lidia Sacchetto, Roberto Zanetti, Stefano Rosso, Bruce K Armstrong, Terence Dwyer, Alison Venn, Richard P Gallagher, Stephen B Gruber, Loraine D Marrett, Hoda Anton-Culver, Klaus Busam, Colin B Begg, Marianne Berwick
Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB...
October 9, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28968778/neuronal-expression-of-opioid-gene-is-controlled-by-dual-epigenetic-and-transcriptional-mechanism-in-human-brain
#15
Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Mumtaz Malik Taqi, Lada Stålhandske, Dineke S Verbeek, Jan Mulder, Grazyna Rajkowska, Donna Sheedy, Jillian Kril, Xueguang Sun, Ann-Christine Syvänen, Tatiana Yakovleva, Georgy Bakalkin
Molecular mechanisms that define patterns of neuropeptide expression are essential for the formation and rewiring of neural circuits. The prodynorphin gene (PDYN) gives rise to dynorphin opioid peptides mediating depression and substance dependence. We here demonstrated that PDYN is expressed in neurons in human dorsolateral prefrontal cortex (dlPFC), and identified neuronal differentially methylated region in PDYN locus framed by CCCTC-binding factor binding sites. A short, nucleosome size human-specific promoter CpG island (CGI), a core of this region may serve as a regulatory module, which is hypomethylated in neurons, enriched in 5-hydroxymethylcytosine, and targeted by USF2, a methylation-sensitive E-box transcription factor (TF)...
July 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28963367/trevo-stent-retriever-mechanical-thrombectomy-for-acute-ischemic-stroke-secondary-to-large-vessel-occlusion-registry
#16
Osama O Zaidat, Alicia C Castonguay, Raul G Nogueira, Diogo C Haussen, Joey D English, Sudhakar R Satti, Jennifer Chen, Hamed Farid, Candace Borders, Erol Veznedaroglu, Mandy J Binning, Ajit Puri, Nirav A Vora, Ron F Budzik, Guilherme Dabus, Italo Linfante, Vallabh Janardhan, Amer Alshekhlee, Michael G Abraham, Randall Edgell, Muhammad Asif Taqi, Ramy El Khoury, Maxim Mokin, Aniel Q Majjhoo, Mouhammed R Kabbani, Michael T Froehler, Ira Finch, Sameer A Ansari, Roberta Novakovic, Thanh N Nguyen
BACKGROUND: Recent randomized clinical trials (RCTs) demonstrated the efficacy of mechanical thrombectomy using stent-retrievers in patients with acute ischemic stroke (AIS) with large vessel occlusions; however, it remains unclear if these results translate to a real-world setting. The TREVO Stent-Retriever Acute Stroke (TRACK) multicenter Registry aimed to evaluate the use of the Trevo device in everyday clinical practice. METHODS: Twenty-three centers enrolled consecutive AIS patients treated from March 2013 through August 2015 with the Trevo device...
September 29, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28961166/high-levels-of-circulating-type-ii-collagen-degradation-marker-ctx-ii-are-associated-with-specific-vdr-polymorphisms-in-patients-with-adult-vertebral-osteochondrosis
#17
Sabina Cauci, Marco Viganò, Laura de Girolamo, Paola De Luca, Carlotta Perucca Orfei, Giuseppe Banfi, Giovanni Lombardi, Marco Brayda-Bruno, Alessandra Colombini
Both vitamin D and collagen have roles in osteocartilaginous homeostasis. We evaluated the association between the circulating 25-hydroxyvitamin D (25(OH)D) type I and II collagen degradation products (CTx-I, and CTx-II), and four vitamin D receptor gene (VDR) polymorphisms, in Italian males affected by low back pain (LBP) due to herniation/discopathy and/or vertebral osteochondrosis. FokI, BsmI, ApaI, and TaqI VDR-polymorphisms were detected through PCR-restriction fragment length polymorphism (RFLP), and circulating 25(OH)D, CTx-I and CTx-II were measured by immunoassays in 79 patients (of which 26 had osteochondrosis) and 79 age-, sex- and body mass index (BMI)-matched healthy controls...
September 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28959253/methylation-of-the-vitamin-d-receptor-vdr-gene-together-with-genetic-variation-race-and-environment-influence-the-signaling-efficacy-of-the-toll-like-receptor-2-1-vdr-pathway
#18
Vanessa Meyer, Donovan Sean Saccone, Fidele Tugizimana, Furaha Florence Asani, Tamsyn Jacki Jeffery, Liza Bornman
BACKGROUND: The disparity in prevalence of infectious diseases across the globe is common knowledge. Vitamin D receptor (VDR)-mediated toll-like receptor (TLR) 2/1 signaling produces antimicrobial peptides, which is critical as a first line of defense in innate immunity. Numerous studies disclosed the independent role of genetic polymorphisms in this pathway, vitamin D status or season and more recently epigenetics, as factors contributing to infectious disease predisposition. Few studies address the interaction between environment, genetics, and epigenetics...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28943516/interhospital-transfer-prior-to-thrombectomy-is-associated-with-delayed-treatment-and-worse-outcome-in-the-stratis-registry
#19
Michael T Froehler, Jeffrey L Saver, Osama O Zaidat, Reza Jahan, Mohammad Ali Aziz-Sultan, Richard P Klucznick, Diogo C Haussen, Frank R Hellinger, Dileep R Yavagal, Tom L Yao, David S Liebeskind, Ashutosh P Jadhav, Rishi Gupta, Ameer E Hassan, Coleman O Martin, Hormozd Bozorgchami, Ritesh Kaushal, Raul G Nogueira, Ravi H Gandhi, Eric C Peterson, Shervin R Dashti, Curtis A Given, Brijesh P Mehta, Vivek Deshmukh, Sidney Starkman, Italo Linfante, Scott H McPherson, Peter Kvamme, Thomas J Grobelny, Muhammad S Hussain, Ike Thacker, Nirav Vora, Peng Roc Chen, Stephen J Monteith, Robert D Ecker, Clemens M Schirmer, Eric Sauvageau, Alex Abou-Chebl, Colin P Derdeyn, Lucian Maidan, Aamir Badruddin, Adnan H Siddiqui, Travis M Dumont, Abdulnasser Alhajeri, M Asif Taqi, Khaled Asi, Jeffrey S Carpenter, Alan Boulos, Gaurav Jindal, Ajit S Puri, Rohan Chitale, Eric M Deshaies, David H Robinson, David F Kallmes, Blaise W Baxter, Mouhammad A Jumaa, Peter Sunenshine, Aniel Q Majjhoo, Joey D English, Shuichi Suzuki, Richard D Fessler, Josser E Delgado Almandoz, Jerry C Martin, Nils H Mueller-Kronast
Background -Endovascular treatment with mechanical thrombectomy (MT) is beneficial for acute stroke patients suffering a large vessel occlusion, though treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared to direct presentation. Methods -STRATIS was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke due to anterior-circulation large vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours...
September 24, 2017: Circulation
https://www.readbyqxmd.com/read/28939539/falxuplication-a-novel-method-for-wrap-clipping-a-fusiform-aneurysm-a-technical-note
#20
Martin M Mortazavi, Tania Hassanzadeh, Kianoush Khalili, Sajid S Suriya, M Asif Taqi, Salman A Fard, R Shane Tubbs
BACKGROUND: Various techniques have been used for wrap-clipping a ruptured, fusiform intracranial aneurysm. However, there is no available literature on use of the falx cerebri for wrap-clipping. OBJECTIVE: We present a review of the literature with an illustrative case, with a ruptured fusiform pericallosal artery aneurysm firmly attached to the lower edge of the falx cerebri and not amenable to endovascular intervention. METHODS: While the firm attachment between the inferior falx and the fusiform aneurysm was maintained, a section of the lower thinner part of the falx cerebri firmly attached to the aneurysm was dissected and wrapped around the fusiform aneurysm, stabilized with a fenestrated clip...
September 19, 2017: World Neurosurgery
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