keyword
MENU ▼
Read by QxMD icon Read
search

FokI

keyword
https://www.readbyqxmd.com/read/29922333/association-of-vitamin-d-receptor-bsmi-taqi-foki-and-apai-polymorphisms-with-susceptibility-of-chronic-periodontitis-a-systematic-review-and-meta-analysis-based-on-38-case-control-studies
#1
REVIEW
Fatemeh Mashhadiabbas, Hossein Neamatzadeh, Rezvan Nasiri, Elnaz Foroughi, Soudabeh Farahnak, Parisa Piroozmand, Mahta Mazaheri, Masoud Zare-Shehneh
Background: There has been increasing interest in the study of the association between Vitamin D receptor (VDR) gene polymorphisms and risk of chronic periodontitis. However, the results remain inconclusive. To better understand the roles of VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) in chronic periodontitis susceptibility, we conducted this systematic review and meta-analysis. Materials and Methods: The PubMed, Google Scholar, and Web of Science database were systemically searched to determine all the eligible studies about VDR polymorphisms and risk of chronic periodontitis up to April 2017...
May 2018: Dental Research Journal
https://www.readbyqxmd.com/read/29911037/prevalence-pattern-of-key-polymorphisms-in-the-vitamin-d-receptor-gene-among-patients-of-type-2-diabetes-mellitus-in-northeast-india
#2
Dipti Sarma, Vikram Singh Chauhan, Kandarpa Kumar Saikia, Partha Sarma, Sukanta Nath
Aims: To investigate the association between Vitamin D receptor gene polymorphisms (BsmI, TaqI and FokI) and type 2 diabetes mellitus in patients in north eastern India. Settings and Design: This was a case control study with 40 cases of type 2 diabetes and 20 controls. Materials and Methods: Genomic DNA was extracted from blood and genotyped for the single nucleotide polymorphism (SNPs) of BsmI [rs1544410], TaqI [rs731236] and FokI [rs2228570] by polymerase chain reaction and gene sequencing...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29892263/vitamin-d-receptor-taqi-polymorphism-is-associated-with-reduced-follicle-number-in-women-utilizing-assisted-reproductive-technologies
#3
Mila W Reginatto, Bartira M Pizarro, Roberto A Antunes, Ana C A Mancebo, Luísa Hoffmann, Pâmela Fernandes, Patrícia Areas, Maria I Chiamolera, Rosane Silva, Maria do Carmo Borges de Souza, Enrrico Bloise, Tânia M Ortiga-Carvalho
Purpose: Calcitriol, or 1,25-hydroxycholecalciferol, is the active form of vitamin D. It binds and activates vitamin D receptor (VDR). Infertility and defective folliculogenesis have been observed in female vdr- knockout mice; however, whether VDR polymorphisms affect human ovarian responses to controlled ovarian stimulation (COS) remains unclear. We hypothesized that VDR polymorphisms are associated with infertility and COS responses. Thus, we evaluated the association between the TaqI, BsmI , and FokI VDR polymorphisms and ovarian responses in women undergoing COS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29798391/-association-of-vitamin-d-receptor-and-its-genetic-polymorphisms-with-nasopharyngeal-carcinoma
#4
L Wang, X Chen, Z X Cheng, Z Lian, A D Sun
Objective: To investigate the gene expression and polymorphisms of vitamin D receptor (VDR) in nasopharyngeal carcinoma. Method: The expression of VDR mRNA was detected by fluorescent quantitative PCR in PBMC from 48 patients with nasopharyngeal carcinoma and 48 controls. The FokI and ApaI loci of all subjects were detected by TaqMan-MGB fluorescent probe PCR. Result: The VDR mRNA △Ct value was 9.32±0.91 and 7.31±1.04 in nasopharyngeal carcinoma patients and controls, respectively. Using multivariate Logistic regression analysis, the results showed that the distribution of FokI point Ff genotype in the case group was significantly higher than that in the control group (adjusted OR =1...
December 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29795525/the-association-of-vdr-polymorphisms-and-type-2-diabetes-in-older-people-living-in-community-in-santiago-de-chile
#5
Bárbara Angel, Lydia Lera, Carlos Márquez, Cecilia Albala
INTRODUCTION: Several polymorphisms have been associated with obesity and type 2 diabetes in different populations. OBJECTIVE: To investigate the frequencies of a genetic polymorphism of vitamin D receptor (FokI and BsmI) in patients with T2D. METHODS: The case-control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60-79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects...
May 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29790402/vitamin-d-pathway-gene-polymorphisms-affecting-daclatasvir-plasma-concentration-at-2-weeks-and-1-month-of-therapy
#6
Jessica Cusato, Amedeo De Nicolò, Lucio Boglione, Fabio Favata, Alessandra Ariaudo, Simone Mornese Pinna, Chiara Carcieri, Federica Guido, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio
AIM: Vitamin D (VD) influences genetic expression through its receptor (VDR). VD pathway gene polymorphisms seem to influence antiviral drug pharmacokinetics and therapeutic outcome/toxicity. We investigated the association between daclatasvir (DCV) plasma concentrations and genetic variants (SNPs) associated with the VD pathway. PATIENTS & METHODS: Chronic hepatitis C patients treated with DCV from 2014 to 2016 were included. Genotypes were assessed through real-time PCR and plasma concentrations through liquid chromatography...
June 1, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29767379/individual-cognitive-change-after-dbs-surgery-in-parkinson-s-disease-patients-using-reliable-change-index-methodology
#7
Thomas Foki, Daniela Hitzl, Walter Pirker, Klaus Novak, Gisela Pusswald, Johann Lehrner
Long-term therapy of Parkinson's disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson's patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination...
May 16, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29766002/influence-of-vitamin-d-receptor-gene-polymorphisms-on-response-to-pegylated-interferon-in-chronic-hepatitis-b-egyptian-patients
#8
Gomaa Mostafa-Hedeab, Dina Sabry, Ghada Mostafa Abdelaziz, Manal Ewaiss, Nagla Adli, Wael Fathy
Background: We explored the effect of vitamin D receptor gene ( VDR ) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 µg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels and hepatitis B surface antigen (HBsAg) expression were assessed by ELISA. VDR polymorphisms FokI T>C (rs 10735810), BsmI A>G (rs 1544410), ApaI (rs7975253), and TaqI C>T (rs 731236), were genotyped using real-time PCR...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29727015/association-of-vdr-gene-polymorphisms-and-22-bp-deletions-in-the-promoter-region-of-tlr2%C3%AE-22-196-174-with-increased-risk-of-pulmonary-tuberculosis-a-case-control-study-in-tea-garden-communities-of-assam
#9
Kangjam Rekha Devi, Kaustab Mukherjee, Pradipta Kumar Chelleng, Simanta Kalita, Upasana Das, Kanwar Narain
BACKGROUND: A high number of pulmonary tuberculosis (PTB) cases have been reported from tea garden communities of Assam. Till date, no molecular epidemiological study was performed to investigate the association of candidate gene(s) with the risk PTB in this region. The present case-control study was aimed to investigate the association of vitamin D receptor (VDR) gene polymorphisms and 22 bp deletion in the promoter region of toll-like receptor 2 (TLR2) gene with the risk of PTB in tea garden communities of Assam...
May 4, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29705233/association-of-vitamin-d-receptor-gene-taqi-bsmi-foki-and-apai-polymorphisms-and-susceptibility-to-hallux-valgus-in-the-chinese-population
#10
Tianqi Tao, Yiqiu Jiang, Wang Li, Yang Li, Jing Du, Jianchao Gui
Previous studies have indicated that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with the risk of skeletal malformations with inflammation. However, the potential association of VDR gene polymorphisms with the susceptibility to hallux valgus remains unclear. To clarify this association, we compared the genotypes of 228 patients with hallux valgus with those of 200 controls using the Multiplex SNaPshot system. The χ2 test was used to compare the allele and genotype frequencies between groups, and p ≤ ...
April 25, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29643436/satellite-dna-in-vicia-faba-is-characterized-by-remarkable-diversity-in-its-sequence-composition-association-with-centromeres-and-replication-timing
#11
Laura Ávila Robledillo, Andrea Koblížková, Petr Novák, Katharina Böttinger, Iva Vrbová, Pavel Neumann, Ingo Schubert, Jiří Macas
Satellite DNA, a class of repetitive sequences forming long arrays of tandemly repeated units, represents substantial portions of many plant genomes yet remains poorly characterized due to various methodological obstacles. Here we show that the genome of the field bean (Vicia faba, 2n = 12), a long-established model for cytogenetic studies in plants, contains a diverse set of satellite repeats, most of which remained concealed until their present investigation. Using next-generation sequencing combined with novel bioinformatics tools, we reconstructed consensus sequences of 23 novel satellite repeats representing 0...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29589202/the-impact-of-five-vdr-polymorphisms-on-multiple-sclerosis-risk-and-progression-a-case-control-and-genotype-phenotype-study
#12
Pavel Křenek, Yvonne Benešová, Julie Bienertová-Vašků, Anna Vašků
Vitamin D receptor polymorphisms have been the target of many studies focusing on multiple sclerosis. However, previously reported results have been inconclusive. The objective of this study was to investigate the association between five vitamin D receptor polymorphisms (EcoRV, FokI, ApaI, TaqI, and BsmI) and multiple sclerosis susceptibility and its course. The study was carried out as a case-control and genotype-phenotype study, consisted of 296 Czech multiple sclerosis patients and 135 healthy controls...
April 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29581796/polymorphisms-in-vitamin-d-receptor-genes-in-association-with-childhood-autism-spectrum-disorder
#13
Zengyu Zhang, Sufang Li, Lianfang Yu, Jun Liu
Both genetic and environmental factors have been implicated in the etiology of autism spectrum disorder (ASD). This case-control study aimed to determine the association of single-nucleotide polymorphisms (SNPs) rs731276 (TaqI), rs1568820 (Cdx2), rs1544410 (BsmI), and rs2228570 (FokI) in the vitamin D receptor (VDR) gene with susceptibility of childhood ASD and severity of the disease. A total of 201 children with ASD and 200 healthy controls from the Han Chinese population were recruited. SNP genotyping was carried out by TaqMan probe-based real-time PCR using genomic DNA extracted from blood cells...
2018: Disease Markers
https://www.readbyqxmd.com/read/29569696/association-of-rs2228570-polymorphism-of-vitamin-d-receptor-gene-with-lumbar-degenerative-disc-disease
#14
Selçuk Özdoğan, Cumhur Kaan Yaltirik, Seda Güleç Yilmaz, Ayhan Koçak, Turgay Isbir
AIM: Lumbar degenerative disc disease (LDDD) is the most common cause of lower back pain (LBP) and sciatica. The vitamin D receptor (VDR) gene, which is located on chromosome 12 (12q12-q14), was the first gene reported to be potentially related to intervertebral degenerative disc disease risks. We conducted a case-control study of a Turkish population and investigated the association between the VDR gene rs2228570 FokI polymorphism and the development of LDDD. MATERIAL AND METHODS: This was a prospective case-control study that included 45 patients with LDDD and 49 healthy individuals (control group)...
March 11, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29562138/rational-design-of-mini-cas9-for-transcriptional-activation
#15
Dacheng Ma, Shuguang Peng, Weiren Huang, Zhiming Cai, Zhen Xie
Nuclease dead Cas9 (dCas9) has been widely used for modulating gene expression by fusing with different activation or repression domains. However, delivery of the CRISPR/Cas system fused with various effector domains in a single adeno-associated virus (AAV) remains challenging due to the payload limit. Here, we engineered a set of downsized variants of Cas9 including Staphylococcus aureus Cas9 (SaCas9) that retained DNA binding activity by deleting conserved functional domains. We demonstrated that fusing FokI nuclease domain to the N-terminal of the minimal SaCas9 (mini-SaCas9) or to the middle of the split mini-SaCas9 can trigger efficient DNA cleavage...
April 20, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29560132/associations-between-vdr-gene-polymorphisms-and-colorectal-cancer-susceptibility-an-updated-meta-analysis-based-on-39-case-control-studies
#16
Zhipeng Pan, Mengya Chen, Xingxing Hu, Hua Wang, Jiajia Yang, Congjun Zhang, Faming Pan, Guoping Sun
Background: Recent studies have reported the associations between vitamin D receptor ( VDR ) polymorphisms and colorectal cancer (CRC), but the results were not always consistent. This meta-analysis aims to evaluate whether VDR polymorphisms are associated with CRC susceptibility. Materials And Methods: Studies on the associations between VDR polymorphisms and CRC were retrieved from the Web of Science, PubMed, the Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and Wanfang (Chinese) databases...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29555202/association-of-vitamin-d-receptor-gene-polymorphisms-with-serum-25-oh-d-levels-and-metabolic-syndrome-in-thai-population
#17
Boonnisa Sangkaew, Manit Nuinoon, Nutjaree Jeenduang
Metabolic syndrome (MetS) increases the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The vitamin D receptor gene (VDR) polymorphisms have been found associated with MetS and serum 25(OH)D levels but these associations remain controversial. The aim of this study was to investigate the relationship between the VDR polymorphisms and MetS, metabolic components, and serum 25(OH)D levels within the Thai population. A case-control study included 237 participants with MetS according to the MetS diagnostic criteria of NCEP ATPIII and 376 controls...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29544394/association-of-vitamin-d-receptor-gene-taqi-foki-and-apai-variants-with-arteriovenous-fistula-failure-in-hemodialysis-patients
#18
Can Huzmeli, Gokhan Bagci, Ferhan Candan, Binnur Bagci, Lale Akkaya, Mansur Kayatas
PURPOSE: We investigated the influence of the vitamin D receptor gene TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms in arteriovenous fistula failure in hemodialysis patients. METHODS: This study was carried out with 54 patients who experienced two or more fistula failures in the late period after arteriovenous fistula operation and 58 control patients with no history of arteriovenous fistula failure in 3 years or longer. The polymerase chain reaction-restriction fragment length polymorphism method was used to determine the vitamin D receptor TaqI, FokI, and ApaI polymorphisms...
May 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29535654/using-cognitive-agents-to-train-negotiation-skills
#19
Christopher A Stevens, Jeroen Daamen, Emma Gaudrain, Tom Renkema, Jakob Dirk Top, Fokie Cnossen, Niels A Taatgen
Training negotiation is difficult because it is a complex, dynamic activity that involves multiple parties. It is often not clear how to create situations in which students can practice negotiation or how to measure students' progress. Some have begun to address these issues by creating artificial software agents with which students can train. These agents have the advantage that they can be "reset," and played against multiple times. This allows students to learn from their mistakes and try different strategies...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29530503/vitamin-d-deficiency-and-vitamin-d-receptor-variants-in-mothers-and-their-neonates-are-risk-factors-for-neonatal-sepsis
#20
Safaa I Tayel, Shimaa E Soliman, Hanan M Elsayed
BACKGROUND AND AIM: Increasing prevalence of neonatal sepsis in recent years catch attention to early prevention and management. Vitamin D receptor (VDR) polymorphism can modulate VDR expression level that greatly influences immunity and susceptibility to microbial infections. We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis. METHODS: This work carried on 160 subjects classified into 80 cases (40 mothers and their 40 septic neonates) and 80 healthy controls (40 volunteer mothers and their 40 healthy neonates)...
June 2018: Steroids
keyword
keyword
103910
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"