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Acoustic neuroma

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https://www.readbyqxmd.com/read/28512503/massive-oculomotor-nerve-enlargement-a-case-of-presumed-schwannomatosis
#1
Laura Donaldson, Ryan Rebello, Amadeo Rodriguez
A 45-year-old man presented with a slowly progressive pupil-involving third nerve palsy. Magnetic resonance imaging (MRI) revealed a tubular lesion extending from the interpeduncular cistern through the cavernous sinus and into the left orbit where it branched into a superior and an inferior division, clearly outlining the anatomy of the third cranial nerve. Multiple other, less pronounced, enlarged cranial nerves were noted. The differential diagnosis included chronic inflammatory demyelinating polyneuropathy (CIDP), hereditary motor and sensory neuropathy (HMSN), neurofibromatosis (NF), and schwannomatosis...
June 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28476467/painful-trigeminal-neuropathy-attributed-to-a-space-occupying-lesion-presenting-as-a-toothache-a-report-of-4-cases
#2
Noboru Noma, Makoto Hayashi, Isao Kitahara, Andrew Young, Maasa Yamamoto, Kosuke Watanabe, Yoshiki Imamura
Painful trigeminal neuropathy attributed to a space-occupying lesion (code 13.1.2.5 in the International Classification of Headache Disorders, 3rd edition [beta version]) is an orofacial pain condition that has characteristics of classical trigeminal neuralgia but is caused by a space-occupying lesion. We present 4 cases of intracranial lesions mimicking odontogenic pain as follows: case 1, a 61-year-old woman presented with a chief complaint of aching soreness in the right mandibular molar area for 1 year; case 2, a 59-year-old man presented with severe pain in the left maxillary and mandibular molars; case 3, a 72-year-old man presented with a chief complaint of facial shock-like pain on the left side; and case 4, a 75-year-old man presented with a chief complaint of paroxysmal pain and numbness in the buccal gingiva of the right mandibular molar region...
May 2, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28450850/cholecystokinin-from-local-gut-hormone-to-ubiquitous-messenger
#3
REVIEW
Jens F Rehfeld
Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. It was later shown to be member of a peptide family, which are all ligands for the CCK1 and CCK2 receptors. CCK peptides are known to be synthetized in small intestinal endocrine I-cells and cerebral neurons. But in addition, CCK is expressed in several endocrine glands (pituitary cells, thyroid C-cells, pancreatic islets, the adrenals, and the testes); in peripheral nerves; in cortical and medullary kidney cells; in cardial myocytes; and in cells of the immune system...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28441508/cyberknife-for-treatment-of-vestibular-schwannoma-a-meta-analysis
#4
Hossein Mahboubi, Ronald Sahyouni, Omid Moshtaghi, Kent Tadokoro, Yaser Ghavami, Kasra Ziai, Harrison W Lin, Hamid R Djalilian
Objectives (1) Perform a meta-analysis of the available data on the outcomes of CyberKnife radiosurgery for treatment of vestibular schwannomas (VSs) in the published English-language literature and (2) evaluate the collective outcomes of CyberKnife treatment with respect to tumor control and hearing preservation. Data Sources A thorough literature search of published English-language articles was performed in the PubMed, Ovid, and Cochrane databases. Review Methods A database search was conducted with the keywords "CyberKnife" and "vestibular schwannoma" or "acoustic neuroma...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28430338/yap-taz-and-areg-expression-in-eighth-cranial-nerve-schwannoma
#5
Alessandro Martini, Gino Marioni, Elisabetta Zanoletti, Rocco Cappellesso, Roberto Stramare, Elena Fasanaro, Chiara Faccioli, Luciano Giacomelli, Luca Denaro, Domenico D'Avella, Antonio Mazzoni, Ambrogio Fassina
BACKGROUND: Although the diagnosis and treatment of eighth cranial nerve (VIII CN) schwannoma (acoustic neuroma) has improved over the years, no factors capable of predicting tumor growth have been identified as yet. This study is a preliminary investigation of the expression in sporadic VIII CN schwannomas of Yes-associated protein (YAP), transcriptional coactivator with PDZ-binding motif (TAZ), and amphiregulin (AREG), a direct target gene of YAP and TAZ. The expression of YAP, TAZ and AREG was correlated with the volumetric dimensions of tumors on contrast-enhanced magnetic resonance imaging (ceMRI)...
April 7, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28391530/validation-of-the-facial-dysfunction-domain-of-the-penn-acoustic-neuroma-quality-of-life-panqol-scale
#6
Wouter L Lodder, Guleed H Adan, Chung S Chean, Tristram H Lesser, Samuel C Leong
The objective of this study is to evaluate the strength of content validity within the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale and to compare how it correlates with a facial dysfunction-specific QOL instrument (Facial Clinimetric Evaluation, FaCE). The study design is online questionnaire survey. Members of the British Acoustic Neuroma Association received both PANQOL questionnaires and the FaCE scale. 158 respondents with self-identified facial paralysis or dysfunction had completed PANQOL and FaCE data sets for analysis...
April 8, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28371358/hearing-optimization-in-neurofibromatosis-type-2-a-systematic-review
#7
Simon Kingsley Wickham Lloyd, Andrew Thomas King, Scott Alexander Rutherford, Charlotte Lucy Hammerbeck-Ward, Simon Richard MacKenzie Freeman, Deborah Jane Mawman, Martin O'Driscoll, Dafydd Gareth Evans
BACKGROUND: It is common for patients with Neurofibromatosis type 2 to develop bilateral profound hearing loss hearing loss and this is one of the main determinants of quality of life in this patient group. OBJECTIVES: The aim of this systematic review was to review the current literature regarding hearing outcomes of treatments for vestibular schwannomas in neurofibromatosis type 2 including conservative and medical management, radiotherapy, hearing preservation surgery and auditory implantation in order to determine the most effective way of preserving or rehabilitating hearing Search Strategy: A MESH search in PubMed using search terms (("Neurofibromatosis 2"[Mesh]) AND "Neuroma, Acoustic"[Mesh]) AND "Hearing Loss"[Mesh] was performed...
April 1, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28362891/the-response-of-cystic-acoustic-neuromas-to-radiosurgery
#8
L Dade Lunsford, Gregory Bowden
No abstract text is available yet for this article.
January 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28343920/impact-of-insurance-status-and-race-on-receipt-of-treatment-for-acoustic-neuroma-a-national-cancer-database-analysis
#9
Shearwood McClelland, Ellen Kim, James D Murphy, Jerry J Jaboin
Acoustic neuroma (AN) management involves surgery, radiation, or observation. Previous studies have demonstrated that patient race and insurance status impact in-hospital morbidity/mortality following surgery; however the nationwide impact of these demographics on the receipt of each treatment modality has not been examined. The National Cancer Data Base (NCDB) from 2004 to 2013 identified AN patients. Multivariate analysis adjusted for several variables within each treatment modality, including patient age, race, sex, income, primary payer for care, tumor size, and medical comorbidities...
March 23, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28319458/quality-of-life-in-807-patients-with-vestibular-schwannoma-comparing-treatment-modalities
#10
Géke Soulier, Bibian M van Leeuwen, Hein Putter, Jeroen C Jansen, Martijn J A Malessy, Peter Paul G van Benthem, Andel G L van der Mey, Anne M Stiggelbout
Objective In vestibular schwannoma treatment, the choice among treatment modalities is controversial. The first aim of this study was to examine the quality of life of patients with vestibular schwannoma having undergone observation, radiation therapy, or microsurgical resection. The second aim was to examine the relationship between perceived symptoms and quality of life. Last, the association between quality of life and time since treatment was studied. Study Design Cross-sectional study. Setting Tertiary referral center...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28296312/two-year-experience-with-the-commercial-gamma-knife-check-software
#11
Andy Yuanguang Xu, Jagdish Bhatnagar, Greg Bednarz, Josef Novotny, John Flickinger, L Dade Lunsford, M Saiful Huq
The Gamma Knife Check software is an FDA approved second check system for dose calculations in Gamma Knife radiosurgery. The purpose of this study was to evaluate the accuracy and the stability of the commercial software package as a tool for independent dose verification. The Gamma Knife Check software version 8.4 was commissioned for a Leksell Gamma Knife Perfexion and a 4C unit at the University of Pittsburgh Medical Center in May 2012. Independent dose verifications were performed using this software for 319 radiosurgery cases on the Perfexion and 283 radiosurgery cases on the 4C units...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28264236/influencing-factors-analysis-of-facial-nerve-function-after-the-microsurgical-resection-of-acoustic-neuroma
#12
WenMing Hong, HongWei Cheng, XiaoJie Wang, ChunGuo Feng
OBJECTIVE: To explore and analyze the influencing factors of facial nerve function retainment after microsurgery resection of acoustic neurinoma. METHODS: Retrospective analysis of our hospital 105 acoustic neuroma cases from October, 2006 to January 2012, in the group all patients were treated with suboccipital sigmoid sinus approach to acoustic neuroma microsurgery resection. We adopted researching individual patient data, outpatient review and telephone followed up and the House-Brackmann grading system to evaluate and analyze the facial nerve function...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28258282/evaluation-of-auditory-pathways-using-dti-in-patients-treated-with-gamma-knife-radiosurgery-for-acoustic-neuroma-a%C3%A2-preliminary-report
#13
Serpil Kurtcan, Mustafa Aziz Hatiboglu, Alpay Alkan, Huseyin Toprak, Mehmet Hakan Seyithanoglu, Ayse Aralasmak, Bahar Atasoy, Omer Uysal
PURPOSE: We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings. METHODS: In this study 13 patients with unilateral acoustic neuroma and 11 controls underwent routine magnetic resonance imaging (MRI) and DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured from the bilateral auditory pathways in all individuals before and after GKR...
March 3, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28187056/operative-mortality-rates-of-acoustic-neuroma-surgery-a-national-cancer-database-analysis
#14
Shearwood McClelland, Ellen Kim, James D Murphy, Jerry J Jaboin
INTRODUCTION: Optimal acoustic neuroma (AN) management involves choosing between three treatment modalities: microsurgical excision, radiation, or observation with serial imaging. The reported in-hospital mortality rate of surgery for AN in the United States is 0.5%. However, there has yet to be a nationwide examination of the AN surgery mortality rate encompassing the period beyond initial hospital discharge. METHODS: The National Cancer Data Base (NCDB) from 2004 to 2013 identified AN patients receiving surgery...
June 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28178141/a-non-surgical-approach-to-the-management-of-exposure-keratitis-due-to-facial-palsy-by-using-mini-scleral-lenses
#15
Victor Zaki
RATIONALE: This is a retrospective study aimed to determine the efficacy of mini-scleral contact lens in protecting the cornea and improving vision in cases of facial palsy. PATIENT CONCERNS: Patients with facial palsy get exposure keratitis because the cornea is dry. They feel pain, discomfort and excessive watering. If left untreated, it leads to permanent damage to the cornea and loss of good functional vision. Mini-scleral lens keep the cornea covered by saline solution all wearing hours...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28116984/validation-of-the-penn-acoustic-neuroma-quality-of-life-scale-panqol-for-spanish-speaking-patients
#16
Maria Del Mar Medina, Alvaro Carrillo, Ruben Polo, Borja Fernandez, Daniel Alonso, Miguel Vaca, Adela Cordero, Cecilia Perez, Alfonso Muriel, Ignacio Cobeta
Objective To perform translation, cross-cultural adaptation, and validation of the Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL) to the Spanish language. Study Design Prospective study. Setting Tertiary neurotologic referral center. Subjects and Methods PANQOL was translated and translated back, and a pretest trial was performed. The study included 27 individuals diagnosed with vestibular schwannoma. Inclusion criteria were adults with untreated vestibular schwannoma, diagnosed in the past 12 months...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28116456/postoperative-imaging-of-the-internal-auditory-canal-visualization-of-active-auditory-implants
#17
I Todt, G Rademacher, P Mittmann, S Mutze, A Ernst
BACKGROUND: Assessment of the internal auditory canal (IAC) and cochlea is of central importance in neurotology. The artefacts and visibility of active auditory implants on magnetic resonance imaging (MRI) vary because of their specific magnetic components. Knowledge of the size of MRI artefacts and the options for handling them is important for the auditory rehabilitation of specific diseases (e. g., vestibular schwannoma). METHODS: The current article is a literature review...
January 23, 2017: HNO
https://www.readbyqxmd.com/read/28048547/we-ab-209-06-dynamic-collimator-trajectory-algorithm-for-use-in-vmat-treatment-deliveries
#18
L MacDonald, C Thomas, A Syme
PURPOSE: To develop advanced dynamic collimator positioning algorithms for optimal beam's-eye-view (BEV) fitting of targets in VMAT procedures, including multiple metastases stereotactic radiosurgery procedures. METHODS: A trajectory algorithm was developed, which can dynamically modify the angle of the collimator as a function of VMAT control point to provide optimized collimation of target volume(s). Central to this algorithm is a concept denoted "whitespace", defined as area within the jaw-defined BEV field, outside of the PTV, and not shielded by the MLC when fit to the PTV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047111/su-f-t-611-critical-analysis-and-efficacy-of-linac-based-beam-modulator-and-cyberknife-treatment-plans-for-acoustic-neuroma-schwannoma
#19
Karrthick Kp, T Kataria, R Thiyagarajan, T Selvan, A Abhishek
PURPOSE: To study the critical analysis and efficacy of Linac and Cyberknife (CK) treatment plans for acoustic neuroma/schwannoma. METHODS: Twelve of acoustic neuroma/schwannoma patients were taken for these study that. Treatment plans were generated in Multiplan treatment planning system (TPS) for CK using 5,7.5 and 10mm diameter collimators. Target volumes were in the range of 0.280 cc to 9.256 cc. Prescription dose (Rx) ranges from 1150cGy to 1950cGy delivered over 1 to 3 Fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046447/su-f-t-612-investigation-of-acoustic-neuroma-planning-for-stereotactic-radiosurgery-utilizing-linac-based-cone-collimators
#20
C Yeboah, M Ruschin, Y Lee, A Sarfehnia, B Chugh, S Myrehaug, M Tsao, H Soliman, A Sahgal
PURPOSE: To assess the feasibility of designing clinically-acceptable stereotactic radiosurgery (SRS) plans utilizing linac-based cone collimators for patients presenting with acoustic neuroma. METHODS: Five acoustic neuroma patients with gross tumour volumes (GTVs) of sizes from 1.3 to 2.7 cc were studied. The cranial-caudal extent of the GTVs range from 1.1 to 1.7 cm whereas the largest cross-sectional extent of the lesions varied from 2.0 to 2.4 cm. No PTV margin was added...
June 2016: Medical Physics
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