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https://www.readbyqxmd.com/read/29624920/lack-of-association-between-vitamin-d-receptor-bsmi-apai-polymorphisms-and-osteoporosis-risk-a-pooled-analysis-on-chinese-individuals
#1
Qing-Xian Wang, Shi-Meng Zhao, Ya-Bin Zhou, Cheng Zhang
BACKGROUND: As for the association between vitamin D receptor (VDR) gene polymorphisms and osteoporosis, the current results have yielded conflicts. Therefore, we performed a pooled analysis based on Chinese individuals to provide comprehensive data on the association between VDR BsmI, ApaI, Tru9I polymorphisms and osteoporosis risk. METHODS: Studies were identified using PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine databases through to January 2017...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29589202/the-impact-of-five-vdr-polymorphisms-on-multiple-sclerosis-risk-and-progression-a-case-control-and-genotype-phenotype-study
#2
Pavel Křenek, Yvonne Benešová, Julie Bienertová-Vašků, Anna Vašků
Vitamin D receptor polymorphisms have been the target of many studies focusing on multiple sclerosis. However, previously reported results have been inconclusive. The objective of this study was to investigate the association between five vitamin D receptor polymorphisms (EcoRV, FokI, ApaI, TaqI, and BsmI) and multiple sclerosis susceptibility and its course. The study was carried out as a case-control and genotype-phenotype study, consisted of 296 Czech multiple sclerosis patients and 135 healthy controls...
March 28, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29581796/polymorphisms-in-vitamin-d-receptor-genes-in-association-with-childhood-autism-spectrum-disorder
#3
Zengyu Zhang, Sufang Li, Lianfang Yu, Jun Liu
Both genetic and environmental factors have been implicated in the etiology of autism spectrum disorder (ASD). This case-control study aimed to determine the association of single-nucleotide polymorphisms (SNPs) rs731276 (TaqI), rs1568820 (Cdx2), rs1544410 (BsmI), and rs2228570 (FokI) in the vitamin D receptor (VDR) gene with susceptibility of childhood ASD and severity of the disease. A total of 201 children with ASD and 200 healthy controls from the Han Chinese population were recruited. SNP genotyping was carried out by TaqMan probe-based real-time PCR using genomic DNA extracted from blood cells...
2018: Disease Markers
https://www.readbyqxmd.com/read/29560132/associations-between-vdr-gene-polymorphisms-and-colorectal-cancer-susceptibility-an-updated-meta-analysis-based-on-39-case-control-studies
#4
Zhipeng Pan, Mengya Chen, Xingxing Hu, Hua Wang, Jiajia Yang, Congjun Zhang, Faming Pan, Guoping Sun
Background: Recent studies have reported the associations between vitamin D receptor ( VDR ) polymorphisms and colorectal cancer (CRC), but the results were not always consistent. This meta-analysis aims to evaluate whether VDR polymorphisms are associated with CRC susceptibility. Materials And Methods: Studies on the associations between VDR polymorphisms and CRC were retrieved from the Web of Science, PubMed, the Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and Wanfang (Chinese) databases...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29555202/association-of-vitamin-d-receptor-gene-polymorphisms-with-serum-25-oh-d-levels-and-metabolic-syndrome-in-thai-population
#5
Boonnisa Sangkaew, Manit Nuinoon, Nutjaree Jeenduang
Metabolic syndrome (MetS) increases the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The vitamin D receptor gene (VDR) polymorphisms have been found associated with MetS and serum 25(OH)D levels but these associations remain controversial. The aim of this study was to investigate the relationship between the VDR polymorphisms and MetS, metabolic components, and serum 25(OH)D levels within the Thai population. A case-control study included 237 participants with MetS according to the MetS diagnostic criteria of NCEP ATPIII and 376 controls...
March 16, 2018: Gene
https://www.readbyqxmd.com/read/29506625/vdbp-vdr-mutations-and-other-factors-related-with-vitamin-d-metabolism-may-be-associated-with-type-1-diabetes-mellitus
#6
Deniz Kirac, Ceyda Dincer Yazan, Hazal Gezmis, Ali Yaman, Goncagul Haklar, Onder Sirikci, Elif Cigdem Altunok, Oguzhan Deyneli
Type 1 diabetes mellitus (T1DM) is an insulin dependent autoimmune disorder resulting the progressive destruction of pancreatic beta cells. Another possible factor considered to be related with T1DM is vitamin D deficiency. Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism. Fifty five T1DM paitents and 40 healthy volunteers were recruited to the study. FokI (rs2228570), BsmI (rs1544410) mutations in VDR; rs4588 and rs7041 polymorphisms in VDBP were investigated with real-time polymerase chain reaction (RT-PCR)...
February 28, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29480871/association-of-vitamin-d-receptor-bsmi-rs1544410-and-apai-rs7975232-polymorphisms-with-susceptibility-to-adolescent-idiopathic-scoliosis-a-systematic-review-and-meta-analysis
#7
Xin Yin, Huadong Wang, Jidong Guo, Liang Zhang, Yupeng Zhang, Li Li, Shuxun Hou
BACKGROUND: AIS is the most common spinal deformity disease, yet its etiology remains uncertain. Significant associations have been found between AIS risk and vitamin D receptor (VDR) gene polymorphisms; however, some of these results are controversial. The aim of this study was to determine whether VDR BsmI rs1544410 and ApaI rs7975232 polymorphisms are correlated with AIS. METHODS: Databases, including PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database, were systematically searched, and eligible case-control studies that explored the association of VDR (BsmI and ApaI) and the susceptibility to AIS were selected...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29467039/influence-of-lifestyle-characteristics-and-vdr-polymorphisms-as-risk-factors-for-intervertebral-disc-degeneration-a-case-control-study
#8
Luiz Angelo Vieira, Aline Amaro Dos Santos, Carla Peluso, Caio Parente Barbosa, Bianca Bianco, Luciano Miller Reis Rodrigues
BACKGROUND: Intervertebral disc degeneration (DD) is an important cause of low back pain and its precise aetiology is not fully understood, being attributed to cumulative environmental, biomechanical and genetic effects. The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Polymorphisms in VDR gene were previously associated with DD process, however with conflicting results...
February 21, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29465575/impact-of-vitamin-d-receptor-and-binding-protein-gene-polymorphisms-in-clinical-and-laboratory-data-of-hcv-patients-cross-sectional-study
#9
Letícia de Paula Scalioni, Betânia Rodrigues Dos Santos, Poli Mara Spritzer, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Priscila Pollo-Flores, Eliane Bordalo Cathalá Esberard, Carlos Eduardo Brandão-Mello, Elisabeth Lampe, Livia Melo Villar
Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29458003/fgf-23-pth-and-vitamin-d-status-in-end-stage-renal-disease-patients-affected-by-vdr-foki-and-bsmi-variants
#10
Mouna Bouksila, Wajih Kaabachi, Mehdi Mrad, Wided Smaoui, Elhem Cheour El Kateb, Mohammed Karim Zouaghi, Kamel Hamzaoui, Afef Bahlous
OBJECTIVES: The aim of this study was to evaluate the association between two VDR SNPs FokI and BsmI and mineral status in ESRD patients. DESIGN AND METHODS: Our case-control study included 100 patients with chronic renal failure in ESRD and 149 healthy subjects. We measured the serum Vitamin D levels and the serum intact PTH level by Electrochemiluminescence Technology (cobas E411 analyzer). We evaluated the serum FGF23 levels by indirect ELISA method. The genotyping of two VDR gene variants FokI and BsmI was carried out by PCR-RFLP technique...
February 16, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29409283/relationship-of-vitamin-d-receptor-gene-polymorphisms-with-susceptibility-surgical-outcome-and-prognosis-of-hallux-valgus-in-a-chinese-han-population
#11
Tianqi Tao, Yiqiu Jiang, Wang Li, Yang Li, Jing Du, Jianchao Gui
BACKGROUND: This study aimed to identify the relationship between the vitamin D receptor (VDR) BsmI gene polymorphism and risk factors, surgical outcome and prognosis of hallux valgus (HV). METHODS: A case-control study was performed on a cohort of 236 HV patients and 236 controls in a Chinese Han population. Detection of the VDR BsmI/G2A polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. RESULTS: We detected a statistically significant difference in the allele distribution of the BsmI polymorphism between cases and controls (p<0...
October 28, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29391820/relationship-of-vitamin-d-receptor-gene-polymorphisms-in-helicobacter-pylori-gastric-patients
#12
Dinelma de Jesus Martins, Gyselly Cb Matos, Rosane Sp Loiola, Vivian D'Annibale, Tereza Corvelo
Purpose: The present study aimed to investigate the association between the human VDR gene and Helicobacter pylori infection. Patients and methods: A cross-sectional study was conducted on 208 adult patients with upper gastrointestinal symptoms. Gastric biopsy specimens were obtained from each patient for molecular DNA and histological examination. Patients were genotyped for VDR gene polymorphisms using polymerase chain reaction and restriction fragment length polymorphism analysis...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29388852/associations-between-vitamin-d-receptor-polymorphisms-and-susceptibility-to-behcet-s-disease-a-meta-analysis
#13
Zahra Mirfeizi, Samira Tabaei, Yalda Ravanshad, Kamila Hashemzadeh, Elahe Kharazmi, Hassan Mehrad-Majd
BACKGROUND: The vitamin D receptor (VDR) gene polymorphisms have been reported to be related to the development of Behcet's disease (BD). However, the results have been inconsistent among diverse populations. Therefore, this comprehensive meta-analysis has been designed to assess a more accurate association between VDR polymorphisms and BD susceptibility. METHODS: An electronic literature search was conducted to identify eligible studies. Pooled odds ratios (OR) with corresponding 95% confidence interval (CI) were calculated in different genetic models to assess this association...
February 1, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29343720/associations-between-vdr-gene-polymorphisms-and-osteoporosis-risk-and-bone-mineral-density-in-postmenopausal-women-a-systematic-review-and-meta-analysis
#14
Liang Zhang, Xin Yin, Jingcheng Wang, Daolinag Xu, Yongxiang Wang, Jiandong Yang, Yuping Tao, Shengfei Zhang, Xinmin Feng, Caifeng Yan
Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Overall, there were significant correlations between VDR ApaI, VDR FokI and PMOP susceptibility. Subgroup analysis showed that VDR ApaI polymorphism significantly decreased the osteoporosis risk in Caucasian postmenopausal women...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29248582/association-between-vitamin-d-receptor-polymorphisms-and-hepatitis-b-virus-infection-susceptibility-a-meta-analysis-study
#15
REVIEW
Qiao He, Yecai Huang, Li Zhang, Yan Yan, Jingyi Liu, Xiaoyu Song, Weixian Chen
BACKGROUND: Hepatitis B virus (HBV) infection is still a serious public health problem. Understanding risk factors associated with development of HBV is greatly important. Numerous studies focus on relationship between vitamin D receptor (VDR) polymorphisms (TaqI, FokI, ApaI, BsmI) and the risk of HBV infection in different ethnic groups. However the results published so far are inconsistent. The aim of this study is to quantify the association between VDR polymorphisms with HBV infection by meta-analysis approach...
March 1, 2018: Gene
https://www.readbyqxmd.com/read/29238479/vitamin-d-receptor-gene-polymorphisms-as-a-risk-factor-for-obesity-in-saudi-men
#16
Ayman Saeed Al-Hazmi, Mazin Mohammed Al-Mehmadi, Sarah Mohammad Al-Bogami, Ashjan Ali Shami, Ahmed Ali Al-Askary, Anas Mohammad Alomery, Saad Saeed Al-Shehri, Haytham Dahlawi, Khadija Abdulrazag, Tariq Ali, Abdalaziz Al-Bogami, Emad Sheshah, Abdalaziz Al-Mutairi, Salh Al-Suhimi, Faris Alharb
Background: The prevalence of obesity and vitamin D deficiency in Saudi Arabia has increased recently. Decreased physical activity might play a role in obesity. Previous studies showed an association between low vitamin D level and its receptor polymorphism with obesity development. Objective: To determine association of low vitamin D level and its receptor polymorphism with obesity in Saudi men. Methods: This case control study was carried out from March 2016 through March 2017...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29230954/association-between-vitamin-d-receptor-polymorphisms-and-systemic-lupus-erythematosus-in-an-indian-cohort
#17
Harishankar Mahto, Rina Tripathy, Bidyut K Das, Aditya K Panda
AIM: Systemic lupus erythematosus (SLE) is an autoimmune disorder with various clinical manifestations. Susceptibility to development of SLE has been linked to several factors, such as genetic, environmental and hormonal. Vitamin D appears to have a regulatory role on disease manifestation and activity. Vitamin D exerts its effect through vitamin D receptors (VDR). Several studies have demonstrated an association between VDR polymorphisms and susceptibility to SLE in different populations, although the results are still inconclusive...
February 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29208185/association-between-vitamin-d-receptor-bsmi-gene-polymorphism-and-periodontitis-a-meta-analysis-in-a-single-ethnic-group
#18
Ting Cai, Zheng-Yan Yang, Li Nie, Jia-Xiu Zhen, Li Deng, Zhi Zhou
Although many researchers have studied on the association between vitamin D receptor (VDR) BsmI polymorphism and periodontitis, this association remains elusive. To further assess the effects of VDR BsmI polymorphism on the risk of periodontitis, a meta-analysis was performed in a single ethnic group. We searched PubMed and Chinese databases for relevant studies till April 2017. The strength of the associations were assessed used pooled odds ratios (ORs) and 95% confidence intervals (CIs). Six studies including 757 periodontitis cases and 670 controls were identified at last...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29110148/association-between-vdr-polymorphisms-and-multiple-sclerosis-systematic-review-and-updated-meta-analysis-of-case-control-studies
#19
Yan-Jie Zhang, Li Zhang, Shan-Yu Chen, Guo-Jun Yang, Xiao-Lei Huang, Yu Duan, Li-Juan Yang, Dong-Qing Ye, Jing Wang
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in multiple sclerosis (MS). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and MS risk. The aim of the current study was to quantify the magnitude of the association between BsmI, FokI, ApaI, and TaqI VDR polymorphisms and MS risk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search and meta-analysis of the VDR gene polymorphisms and the risk of MS...
November 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29099735/effect-of-pharmacogenetic-markers-of-vitamin-d-pathway-on-deferasirox-pharmacokinetics-in-children
#20
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics in a cohort of pediatric patients. PATIENTS AND METHODS: Eighteen children with β-thalassemia were enrolled. Drug plasma concentrations at the end of dosing interval (Ctrough) and after 0, 2, 4, 6, and 24 h of drug administration were measured by a HPLC-UV method...
January 2018: Pharmacogenetics and Genomics
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