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Juan Yang, Katherine E Atkins, Luzhao Feng, Mingfan Pang, Yaming Zheng, Xinxin Liu, Benjamin J Cowling, Hongjie Yu
BACKGROUND: To explore the current landscape of seasonal influenza vaccination across China, and estimate the budget of implementing a national "free-at-the-point-of-care" vaccination program for priority populations recommended by the World Health Organization. METHODS: In 2014 and 2016, we conducted a survey across provincial Centers for Disease Control and Prevention to collect information on regional reimbursement policies for influenza vaccination, estimated the national uptake using distributed doses of influenza vaccines, and evaluated the budget using population size and vaccine cost obtained from official websites and literatures...
October 13, 2016: Vaccine
Aline Hajj, Rima Chedid, Eliane Chouery, André Megarbané, Marie-Hélène Gannagé-Yared
AIM: To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin. MATERIALS & METHODS: Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed. RESULTS: In men, BsmI, ApaI and TaqI were associated with BMI and WC (p < 0...
October 2016: Pharmacogenomics
Xiaolei Feng, Sihua Wang, Xiaoran Duan, Chunyang Li, Zhen Yan, Feifei Feng, Songcheng Yu, Yongjun Wu, Wei Wang
BACKGROUND: In recent research, it has been shown that rs2289487 within the PLIN1 gene has different variants that have been associated with obesity, type 2 diabetes, and other diseases. However, the isochizomers such as the BsmI enzyme required for detection of this polymorphism through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method are expensive. In this study, we aimed to explore a novel PCR-RFLP method for identifying the single-nucleotide polymorphism (SNP) of rs2289487 of PLIN1 gene...
April 13, 2016: Journal of Clinical Laboratory Analysis
Dong-Dong Zhao, Dan-Dan Yu, Qiong-Qiong Ren, Bao Dong, Feng Zhao, Ye-Huan Sun
BACKGROUND: As for the association of vitamin D receptor (VDR) gene polymorphisms with susceptibility to pediatric asthma, results of published studies yielded conflicts. A systematic review was conducted on the relationship between childhood asthma and VDR gene polymorphisms, including ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236). METHODS: PubMed, Web of Science, CBM (Chinese Biomedical Database), CNKI (China National Knowledge Infrastructure), and Wanfang (Chinese) database were searched for relevant studies...
August 23, 2016: Pediatric Pulmonology
Morteza Dehghan, Razieh Pourahmad-Jaktaji
INTRODUCTION: Vitamin D receptor gene is one of candidate genes related to osteoporosis expansion. The association of ApaI, TaqI, BsmI polymorphisms in vitamin D receptor gene with bone metabolism and density has been area of interest in many studies. AIM: This study was conducted to further investigate the association between the ApaI, TaqI, BsmI polymorphisms and bone density. This study was analytical study. Centers for bone density measurement in southwestern Iran...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Soranun Chantarangsu, Thanyachai Sura, Sanutm Mongkornkarn, Kobkiat Donsakul, Kitti Torrungruang
BACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the susceptibility to infections and bone-related diseases. However, their relationship with periodontal disease remains unclear. This cross-sectional study investigated whether the susceptibility to chronic periodontitis (CP) in a Thai population is associated with VDR polymorphisms. METHODS: Genomic DNA was obtained from 1,460 subjects, aged 39-66. Genotyping of VDR polymorphisms (FokI, BsmI, ApaI, and TaqI) was performed using real-time polymerase chain reaction...
August 4, 2016: Journal of Periodontology
Fei Yu, Ling Ling Cui, Xing Li, Chong Jian Wang, Yue Ba, Ling Wang, Jing Li, Chao Li, Li Ping Dai, Wen Jie Li
BACKGROUND AND OBJECTIVES: Vitamin D receptor (VDR) genetic polymorphisms are considered to be associated with type 2 diabetes mellitus (T2DM), but this is inconclusive. The aim of this study is to quantify the association between polymorphisms of BsmI and FokI in the VDR gene and T2DM risk through literature review. METHODS AND STUDY DESIGN: Original articles published from 1999 to June 2014 were discovered through PubMed, ISI Web of Science, China National Knowledge Infrastructure, Chinese Wanfang Database, and the Chinese Biomedical Literature Database...
2016: Asia Pacific Journal of Clinical Nutrition
Yingjuan Lv, Qingbin Yao, Wenjiang Ma, Hua Liu, Jian Ji, Xiaorong Li
BACKGROUND: Vitamin D deficiency and vitamin D receptor gene polymorphisms are known to be significantly associated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is largely unknown. This study investigated whether vitamin D receptor gene polymorphisms are altered in primary open-angle glaucoma subjects carrying the risk allele, and whether vitamin D deficiency is an important factor in the development of glaucoma. METHODS: Seventy-three POAG patients and 71 age-matched controls from the Han population were enrolled...
2016: BMC Ophthalmology
Rasoul Abdollahzadeh, Mahsa Sobhani Fard, Farideh Rahmani, Kaveh Moloudi, Behrooz Sadeghi Kalani, Asaad Azarnezhad
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) with a complex etiology. Given the Vitamin D receptor (VDR) gene, it is considered an outstanding risk component associated with MS. The aim of the present study has been to explore and emphasize the role of ApaI, BsmI, TaqI and FokI polymorphisms of VDR gene in susceptibility to MS in an Iranian case-control population including 160 patients and 150 healthy controls. All cases were clinically diagnosed with relapsing-remitting (RR) form, and the controls were age, gender, and race matched which were completely in agreement with the case group...
August 15, 2016: Journal of the Neurological Sciences
Seo Young Kang, Suyeon Park, Eungseok Oh, Jinse Park, Jinyoung Youn, Ji Sun Kim, Jeong-Uk Kim, Wooyoung Jang
Recently, the effect of genetic variants in the Vitamin D receptor (VDR) gene on Parkinson's disease (PD) has gained interest. However, the precise relationship between VDR polymorphisms and PD remains unclear. In Korea, one study reported an association between VDR gene polymorphisms and PD. However, this study was conducted with a small sample size, and only the Bsml locus was evaluated. Therefore, further investigations about the relationship between VDR polymorphisms and PD are necessary in a Korean population...
August 15, 2016: Neuroscience Letters
Daniel Čierny, Jozef Michalik, Mária Škereňová, Ema Kantorová, Štefan Sivák, Juraj Javor, Egon Kurča, Dušan Dobrota, Ján Lehotský
OBJECTIVE: Vitamin D acts through vitamin D receptor (VDR) and has promising beneficial effects in the development and progression of multiple sclerosis (MS). The purpose of our study was to investigate the possible association of the VDR gene polymorphisms ApaI, BsmI and TaqI with the MS susceptibility and with the rate of disease disability progression in the Central European Slovak population. METHODS: The allele and genotype variants of ApaI, TaqI and BsmI VDR gene polymorphisms were analysed in 270 clinically diagnosed MS patients and 303 healthy controls...
August 2016: Neurological Research
Hoda Rasheed, Rehab A Hegazy, Heba I Gawdat, Dina A Mehaney, Marwa M Kamel, Marwa M Fawzy, Mohammed M Nooh, Hebatallah A Darwish
BACKGROUND: Vitamin D has been considered a key player in various malignancies including cutaneous cancers. To date, mycosis fungoides (MF) has been the least studied in relation to vitamin D. Furthermore, the vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) have not been tackled before in the context of MF, despite their incrimination in numerous diseases. AIM OF STUDY: To assess the role of vitamin D in MF by measuring its serum level, and studying VDR SNPs (TaqI, BsmI, FokI) in different stages of MF...
2016: PloS One
Nan Jiang, Xing-Qi Zhao, Cheng-He Qin, Yan-Jun Hu, Lei Wang, Guo-Ping Xie, Sheng-Nan Wang, Li-Guang Chen, Bin Yu
Previous studies have indicated that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with the risk of several inflammatory diseases. However, potential association of the VDR gene polymorphisms with susceptibility to extremity chronic osteomyelitis remains unclear. The present study aimed to investigate link between VDR gene polymorphisms and the risk of extremity chronic osteomyelitis in Chinese population. A total of 233 patients with chronic osteomyelitis and 200 healthy controls were genotyped for the 4 single-nucleotide polymorphisms (SNPs) (TaqI, BsmI, FokI and ApaI) in VDR gene using the SNaPshot genotyping method...
August 2016: Injury
Khayal A Alkhayal, Zainab H Awadalia, Mansoor-Ali Vaali-Mohammed, Omar A Al Obeed, Alanoud Al Wesaimer, Rabih Halwani, Ahmed M Zubaidi, Zahid Khan, Maha-Hamadien Abdulla
BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). VDR is a transcription factor modulating the expression of several genes in different pathways. Genetic variants in the VDR gene have been associated with several cancers in different population including colorectal cancer. OBJECTIVE: To assess the association of VDR gene polymorphisms in relation with colorectal cancer (CRC) in a Saudi population...
2016: PloS One
Sha Liao, Jun He, Xiaoxia Li, Honexia Xu, Xiuying Liu, Yi Zhao, Yuhong Zhang
OBJECTIVE: To explore the association between the vitamin D receptor (VDR) gene polymorphisms and HOMA index in prediabetes. METHODS: On the basis of a cross-sectional study which was conducted in Ningxia during 2008-2012, 339 controls and 468 subjects with prediabetes were selected according to ADA diabetes diagnosis standards. Anthropometric data and blood samples were collected in the field investigation. Blood biochemistry analyses and insulin determination were carried out in the laboratory...
March 2016: Wei Sheng Yan Jiu, Journal of Hygiene Research
Duygu Gezen-Ak, Merve Alaylıoğlu, Gençer Genç, Ayşegül Gündüz, Esin Candaş, Başar Bilgiç, İrem L Atasoy, Hülya Apaydın, Güneş Kızıltan, Hakan Gürvit, Haşmet Hanağası, Sibel Ertan, Selma Yılmazer, Erdinç Dursun
Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D transport, to determine whether vitamin D receptor (VDR) haplotype that we previously demonstrated to be a risk haplotype for AD is also a common haplotype for PD and to investigate any relevant consequence of serum 25OHD levels, GC or VDR genotypes on clinical features of PD...
June 9, 2016: Neuromolecular Medicine
Lynne McNamara, Simbarashe Takuva, Tobias Chirwa, Patrick MacPhail
BACKGROUND: Host genetic factors may a play role in susceptibility to infection. Vitamin-D is an immunomodulator that may play a role in HIV infection. Vitamin-D action is mediated by the vitamin-D receptor. We establish prevalence of ApaI, BsmI, FokI and TaqI polymorphisms (VDRPs) amongst a black southern African HIV+ve population and investigate polymorphic differences between HIV+ve and -ve people. METHODS: Seventy-nine sex and age-group matched HIV+ve patients of African origin initiating antiretroviral therapy (ART) and 79 HIV-ve participants, also of African origin, were recruited from a public sector HIV testing and treatment clinic and investigated for the 4 polymorphisms...
2016: International Journal of Molecular Epidemiology and Genetics
Chi Huang, Chao-Jie Liu, Xiong-Fei Pan, Xiang Liu, Ning-Xiu Li
BACKGROUND: Preventive care has an essential role in reducing income-related health inequalities. Despite a general consensus of the need of shifting focus from disease treatment to wellness and prevention, little is known about inequalities in access to preventive care in China. Our study aimed to explore the inequalities in preventive care usage and factors that were associated with such inequalities among Chinese adults. METHODS: Multilevel logistic regression analyses were performed using national data from the 2011 Chinese Health and Nutrition Survey...
2016: BMC Health Services Research
Chunming Yang, Jia Li, Yan Li, Di Wu, Chengguang Sui, Youhong Jiang, Fandong Meng
Molecular epidemiologic studies previously reported that 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3) appears to influence cancer risk. It exerts its activity through the intracellular vitamin D receptor (VDR), which regulates the transcription of genes. This study aimed to investigate the genetic association of VDR polymorphisms with renal cell carcinoma (RCC) risk in the Chinese population. The genotypes of five VDR polymorphisms (TaqI, BsmI, Cdx-2, ApaI, and FokI) were studied using polymerase chain reaction in 302 RCC patients and 302 healthy controls...
2016: Scientific Reports
S Kılıç, F Sılan, M M Hız, S Işık, Z Ögretmen, Ö Özdemir
BACKGROUND AND OBJECTIVE: The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. PATIENTS AND METHODS: This cross-sectional case control study was performed between March 2013 and April 2014 at the University Hospital in Çanakkale, Turkey. Peripheral blood samples were collected in EDTA tubes...
2016: Journal of Investigational Allergology & Clinical Immunology
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