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https://www.readbyqxmd.com/read/29110148/association-between-vdr-polymorphisms-and-multiple-sclerosis-systematic-review-and-updated-meta-analysis-of-case-control-studies
#1
Yan-Jie Zhang, Li Zhang, Shan-Yu Chen, Guo-Jun Yang, Xiao-Lei Huang, Yu Duan, Li-Juan Yang, Dong-Qing Ye, Jing Wang
Vitamin D receptor (VDR) polymorphisms have been inconsistently investigated in multiple sclerosis (MS). However, published studies demonstrated differences concerning design and effect size. A meta-analysis is necessary to determine the magnitude of the association between VDR polymorphisms and MS risk. The aim of the current study was to quantify the magnitude of the association between BsmI, FokI, ApaI, and TaqI VDR polymorphisms and MS risk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search and meta-analysis of the VDR gene polymorphisms and the risk of MS...
November 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29099735/effect-of-pharmacogenetic-markers-of-vitamin-d-pathway-on-deferasirox-pharmacokinetics-in-children
#2
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics in a cohort of pediatric patients. PATIENTS AND METHODS: Eighteen children with β-thalassemia were enrolled. Drug plasma concentrations at the end of dosing interval (Ctrough) and after 0, 2, 4, 6, and 24 h of drug administration were measured by a HPLC-UV method...
November 2, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29069366/uncommon-carbapenemase-encoding-plasmids-in-the-clinically-emergent-acinetobacter-pittii
#3
Liliana Silva, Joana Mourão, Filipa Grosso, Luísa Peixe
Objectives: Two carbapenemase-carrying plasmids, pLS488 (blaOXA-23) and pLS535 (blaOXA-58) from Acinetobacter pittii clinical isolates, were characterized in this study, including their ability to be transferred to Acinetobacter baumannii. Methods: The clinical isolates were obtained from drainage fluid of a patient with biliary tract cancer and from an exudate of a patient with a hip infection (Portuguese University Hospital, 2012). Isolate characterization included antimicrobial susceptibility tests, carbapenemase production by Blue-Carba, carbapenem-hydrolysing class D β-lactamase (CHDL) gene search by PCR sequencing, ApaI-PFGE, CHDL genetic location and plasmid size by hybridization and WGS...
October 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29066872/association-of-vitamin-d-receptor-gene-polymorphisms-with-diabetic-dyslipidemia-in-the-elderly-male-population-in-north-china
#4
Zheng Xia, Yazhuo Hu, Zhitao Han, Ya Gao, Jie Bai, Yao He, Hua Zhao, Honghong Zhang
BACKGROUND: The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China. METHODS: A total of 242 T2DM patients with dyslipidemia (DH group, n=108) or without dyslipidemia (DO group, n=134) and 100 controls were genotyped for ApaI, TaqI and FokI single nucleotide polymorphisms (SNPs) of the VDR gene using polymerase chain reaction-restriction fragment length polymorphism and sequencing...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29066494/vitamin-d-receptor-apai-rs7975232-polymorphism-confers-decreased-risk-of-pulmonary-tuberculosis-in-overall-and-african-population-but-not-in-asians-evidence-from-a-meta-analysis
#5
Mohammed Y Areeshi, Raju K Mandal, Mohd Wahid, Sajad A Dar, Arshad Jawed, Mohtashim Lohani, Amir Mahgoub Awadelkareem Abdallah, Saif Khan, Aditya K Panda, B N Mishra, Shafiul Haque
GOALS: The involvement of the VDR ApaI gene polymorphism in the development of pulmonary tuberculosis (PTB) has been reported by numerous published studies and yielded inconsistent results. The present meta-analysis evaluated the association of VDR ApaI polymorphism and risk of PTB occurrence. PROCEDURES: PubMed (Medline), EMBASE and Google Scholar web-databases were searched and a meta-analysis was performed by calculating the pooled odds ratios (ORs) and 95% confidence intervals (95% CIs)...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29022486/association-of-vitamin-d-receptor-gene-polymorphisms-with-breast-cancer-risk-in-an-egyptian-population
#6
Haidan M El-Shorbagy, Nada H Mahmoud, Salwa Sabet
This study aimed to explore whether genetic polymorphisms in vitamin D receptor are correlated to the breast cancer prevalence in an Egyptian population. Polymerase chain reaction-restriction fragment polymorphism was used to genotype three frequently analyzed vitamin D receptor gene single-nucleotide polymorphisms (rs1544410, rs7975232, and rs731236) and were identified by sequencing analysis. This is the first study that recorded a new single-nucleotide polymorphism in ApaI genotype within an Egyptian population and was registered with the accession number KY859868...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28961166/high-levels-of-circulating-type-ii-collagen-degradation-marker-ctx-ii-are-associated-with-specific-vdr-polymorphisms-in-patients-with-adult-vertebral-osteochondrosis
#7
Sabina Cauci, Marco Viganò, Laura de Girolamo, Paola De Luca, Carlotta Perucca Orfei, Giuseppe Banfi, Giovanni Lombardi, Marco Brayda-Bruno, Alessandra Colombini
Both vitamin D and collagen have roles in osteocartilaginous homeostasis. We evaluated the association between the circulating 25-hydroxyvitamin D (25(OH)D) type I and II collagen degradation products (CTx-I, and CTx-II), and four vitamin D receptor gene (VDR) polymorphisms, in Italian males affected by low back pain (LBP) due to herniation/discopathy and/or vertebral osteochondrosis. FokI, BsmI, ApaI, and TaqI VDR-polymorphisms were detected through PCR-restriction fragment length polymorphism (RFLP), and circulating 25(OH)D, CTx-I and CTx-II were measured by immunoassays in 79 patients (of which 26 had osteochondrosis) and 79 age-, sex- and body mass index (BMI)-matched healthy controls...
September 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28938978/validity-and-reliability-of-the-czech-version-of-the-amsterdam-preoperative-anxiety-and-information-scale-apais
#8
Renáta Zeleníková, Pavlína Homzová, Miroslav Homza, Radka Bužgová
PURPOSE: The purpose of this study was to validate the Czech version of the Amsterdam Preoperative Anxiety and Information Scale (APAIS) in adult patients undergoing elective surgery. DESIGN: A cross-sectional study. METHODS: Data were collected from July 2012 to January 2013. For reliability and validity testing, two instruments measuring preoperative anxiety were administered to the participants on the same occasion, (APAIS and the Spielberg State Anxiety Inventory (STAI-S))...
October 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28868946/vitamin-d-receptor-gene-polymorphisms-and-risk-of-polycystic-ovary-syndrome-in-south-indian-women
#9
Swapna Siddamalla, Tumu Venkat Reddy, Suresh Govatati, Nagendram Erram, Mamata Deenadayal, Sisinthy Shivaji, Manjula Bhanoori
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women. Emerging evidence suggests that Vitamin D Receptor (VDR) might be a causal factor for characteristics associated with PCOS such as obesity and type 2 diabetes. Present study investigated association between VDR gene BsmI A/G (rs1544410), ApaI A/C (rs7975232) and TaqI T/C (rs731236) single nucleotide polymorphisms and PCOS risk in South Indian women. Genotyping of VDR gene SNPs was carried out in PCOS patients (n = 95) and controls (n = 130) by PCR-RFLP method and confirmed by sequencing analysis...
September 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28851298/vitamin-d-receptor-gene-polymorphisms-in-association-with-diabetic-nephropathy-a-systematic-review-and-meta-analysis
#10
REVIEW
Lina Yang, Lan Wu, Yi Fan, Jianfei Ma
BACKGROUND: A large amount of researches have demonstrated that vitamin D receptor (VDR) gene polymorphisms are associated with diabetic nephropathy (DN) risk in diabetes mellitus (DM) patients. Nevertheless, the results are inconclusive and inconsistent. METHODS: We screened PubMed, Embase, Chinese National Knowledge Infrastructure and Chinese Wanfang databases for those relevant studies updated in May 2016. RESULTS: 7 studies involving 2564 subjects were recruited...
August 29, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28832880/association-of-vitamin-d-receptor-polymorphisms-with-the-risk-of-nonmelanoma-skin-cancer-in-adults
#11
Erin M Burns, Purushotham Guroji, Israr Ahmad, Hana M Nasr, Yingxue Wang, Iman A Tamimi, Elijah Stiefel, Mohammad S Abdelgawwad, Abdullah Shaheen, Anum F Muzaffar, Lisa M Bush, Christina B Hurst, Russell L Griffin, Craig A Elmets, Nabiha Yusuf
Importance: Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increase a person's risk for NMSC. Objective: To examine whether the polymorphisms in the VDR gene are associated with the development of NMSC and the demographic characteristics of the participants...
August 23, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28830368/allelic-variants-in-vitamin-d-receptor-gene-are-associated-with-adiposity-measures-in-the-central-european-population
#12
Julie Bienertová-Vašků, Filip Zlámal, Aneta Pohořalá, Ondřej Mikeš, Monika Goldbergová-Pávková, Jan Novák, Zbyněk Šplíchal, Hynek Pikhart
BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. METHODS: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured...
August 22, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28822353/vdr-gene-variation-and-insulin-resistance-related-diseases
#13
Fei-Fei Han, Ya-Li Lv, Li-Li Gong, He Liu, Zi-Rui Wan, Li-Hong Liu
BACKGROUND: Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed vitamin D receptor (VDR) gene polymorphism in relationship with these diseases; however, results remain inconsistent. Our study was conducted to elucidate whether VDR Gene polymorphisms could predict insulin resistance on a large scale. METHODS: A meta-analysis using MEDLINE and EMBASE, was performed up to December 16th, 2016...
August 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28818943/zones-spots-and-planetary-scale-waves-beating-in-brown-dwarf-atmospheres
#14
D Apai, T Karalidi, M S Marley, H Yang, D Flateau, S Metchev, N B Cowan, E Buenzli, A J Burgasser, J Radigan, E Artigau, P Lowrance
Brown dwarfs are massive analogs of extrasolar giant planets and may host types of atmospheric circulation not seen in the solar system. We analyzed a long-term Spitzer Space Telescope infrared monitoring campaign of brown dwarfs to constrain cloud cover variations over a total of 192 rotations. The infrared brightness evolution is dominated by beat patterns caused by planetary-scale wave pairs and by a small number of bright spots. The beating waves have similar amplitudes but slightly different apparent periods because of differing velocities or directions...
August 18, 2017: Science
https://www.readbyqxmd.com/read/28780323/vitamin-d-receptor-gene-polymorphisms-and-the-risk-of-multiple-sclerosis-an-updated-meta-analysis
#15
Xiao-Long Chen, Ming-Liang Zhang, Lin Zhu, Meng-Le Peng, Fang-Zhou Liu, Guang-Xian Zhang, Li-Mei Wang, Jie Zhao
BACKGROUND: The association between vitamin D receptor (VDR) gene polymorphisms and multiple sclerosis (MS) has been extensively studied, but results were controversial. METHODS: This meta-analysis aimed to confirm whether VDR gene polymorphisms were associated with MS. Meta-analysis on the association between MS and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allelic contrast, recessive, homozygotes and dominant models. Data were extracted by standardized forms and odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model if the results were heterogeneous...
August 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28764147/study-of-vitamin-d-receptor-gene-polymorphism-foki-taqi-and-apai-among-prostate-cancer-patients-in-north-india
#16
Pankaj Ramrao Kambale, Deepa Haldar, B C Kabi, Kalpana Pankaj Kambale
INTRODUCTION: Incidence of prostate cancer is rising worldwide. Multiple factors have been suggested for the aetiology of prostate cancer including ethnic, genetic and diet. Vitamin D (calcitriol) has been shown to have role in cell growth and differentiation and its deficiency is implicated as one of the aetiological factors in prostate cancer. Prostatic epithelial cells express Vitamin D Receptor (VDR) as well as 1α- hydroxylase enzyme that are required for the synthesis of calcitriol and its action...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28749628/circulating-25-hydroxy-vitamin-d-relative-to-vitamin-d-receptor-polymorphism-after-vitamin-d3-supplementation-in-breast-cancer-women-a-randomized-double-blind-controlled-clinical-trial
#17
Houra Mohseni, Seyed Ahmad Hosseini, Reza Amani, Alireza Ekrami, Ahmad Ahmadzadeh, Seyed Mahmoud Latifi
Objective: The influence of vitamin D receptor (VDR) genetic variation on serum 25-hydroxyvitamin D levels [25(OH)D] after vitamin D3 supplementation remains unclear. We aimed to investigate changes of 25(OH)D in a randomized, double-blind, placebo-controlled clinical trial, according to VDR genotype, after provision of vitamin D3 to breast cancer cases for a 2-month period. Methods: Participants were assigned to two treatment arms: placebo (n = 28) and vitamin D3 supplementation (n =28). The supplementation group received 50,000 IU of vitamin D every week for 2 months...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28739681/vitamin-d-receptor-polymorphism-and-cancer-an-update
#18
REVIEW
Vikrant Rai, Joe Abdo, Swati Agrawal, Devendra K Agrawal
BACKGROUND: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. The association of VDR polymorphism with cancer has been reported; however, the literature lacks critical analyses of the studies in last 3 years...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28697775/the-relationship-between-vitamin-d-receptor-gene-polymorphism-and-deciduous-tooth-decay-in-chinese-children
#19
Yuan-Yuan Kong, Jian-Mao Zheng, Wen-Juan Zhang, Qian-Zhou Jiang, Xue-Chao Yang, Miao Yu, Su-Juan Zeng
BACKGROUND: In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children. METHODS: Our study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP. RESULTS: The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1...
July 11, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28665452/genetic-polymorphisms-of-vitamin-d-metabolism-genes-and-serum-level-of-vitamin-d-in-colorectal-cancer
#20
Verônica Marques Vidigal, Pedro Nazareth Aguiar Junior, Tiago Donizetti Silva, Juliana de Oliveira, Célia Aparecida Marques Pimenta, Aledson Vitor Felipe, Nora Manoukian Forones
BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. METHODS: One hundred fifty-two CRC patients and 321 controls were included...
June 19, 2017: International Journal of Biological Markers
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