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https://www.readbyqxmd.com/read/28868946/vitamin-d-receptor-gene-polymorphisms-and-risk-of-polycystic-ovary-syndrome-in-south-indian-women
#1
Swapna Siddamalla, Tumu Venkat Reddy, Suresh Govatati, Nagendram Erram, Mamata Deenadayal, Sisinthy Shivaji, Manjula Bhanoori
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women. Emerging evidence suggests that Vitamin D Receptor (VDR) might be a causal factor for characteristics associated with PCOS such as obesity and type 2 diabetes. Present study investigated association between VDR gene BsmI A/G (rs1544410), ApaI A/C (rs7975232) and TaqI T/C (rs731236) single nucleotide polymorphisms and PCOS risk in South Indian women. Genotyping of VDR gene SNPs was carried out in PCOS patients (n = 95) and controls (n = 130) by PCR-RFLP method and confirmed by sequencing analysis...
September 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28851298/vitamin-d-receptor-gene-polymorphisms-in-association-with-diabetic-nephropathy-a-systematic-review-and-meta-analysis
#2
REVIEW
Lina Yang, Lan Wu, Yi Fan, Jianfei Ma
BACKGROUND: A large amount of researches have demonstrated that vitamin D receptor (VDR) gene polymorphisms are associated with diabetic nephropathy (DN) risk in diabetes mellitus (DM) patients. Nevertheless, the results are inconclusive and inconsistent. METHODS: We screened PubMed, Embase, Chinese National Knowledge Infrastructure and Chinese Wanfang databases for those relevant studies updated in May 2016. RESULTS: 7 studies involving 2564 subjects were recruited...
August 29, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28832880/association-of-vitamin-d-receptor-polymorphisms-with-the-risk-of-nonmelanoma-skin-cancer-in-adults
#3
Erin M Burns, Purushotham Guroji, Israr Ahmad, Hana M Nasr, Yingxue Wang, Iman A Tamimi, Elijah Stiefel, Mohammad S Abdelgawwad, Abdullah Shaheen, Anum F Muzaffar, Lisa M Bush, Christina B Hurst, Russell L Griffin, Craig A Elmets, Nabiha Yusuf
Importance: Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increase a person's risk for NMSC. Objective: To examine whether the polymorphisms in the VDR gene are associated with the development of NMSC and the demographic characteristics of the participants...
August 23, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28830368/allelic-variants-in-vitamin-d-receptor-gene-are-associated-with-adiposity-measures-in-the-central-european-population
#4
Julie Bienertová-Vašků, Filip Zlámal, Aneta Pohořalá, Ondřej Mikeš, Monika Goldbergová-Pávková, Jan Novák, Zbyněk Šplíchal, Hynek Pikhart
BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. METHODS: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured...
August 22, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28822353/vdr-gene-variation-and-insulin-resistance-related-diseases
#5
Fei-Fei Han, Ya-Li Lv, Li-Li Gong, He Liu, Zi-Rui Wan, Li-Hong Liu
BACKGROUND: Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed vitamin D receptor (VDR) gene polymorphism in relationship with these diseases; however, results remain inconsistent. Our study was conducted to elucidate whether VDR Gene polymorphisms could predict insulin resistance on a large scale. METHODS: A meta-analysis using MEDLINE and EMBASE, was performed up to December 16th, 2016...
August 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28818943/zones-spots-and-planetary-scale-waves-beating-in-brown-dwarf-atmospheres
#6
D Apai, T Karalidi, M S Marley, H Yang, D Flateau, S Metchev, N B Cowan, E Buenzli, A J Burgasser, J Radigan, E Artigau, P Lowrance
Brown dwarfs are massive analogs of extrasolar giant planets and may host types of atmospheric circulation not seen in the solar system. We analyzed a long-term Spitzer Space Telescope infrared monitoring campaign of brown dwarfs to constrain cloud cover variations over a total of 192 rotations. The infrared brightness evolution is dominated by beat patterns caused by planetary-scale wave pairs and by a small number of bright spots. The beating waves have similar amplitudes but slightly different apparent periods because of differing velocities or directions...
August 18, 2017: Science
https://www.readbyqxmd.com/read/28780323/vitamin-d-receptor-gene-polymorphisms-and-the-risk-of-multiple-sclerosis-an-updated-meta-analysis
#7
Xiao-Long Chen, Ming-Liang Zhang, Lin Zhu, Meng-Le Peng, Fang-Zhou Liu, Guang-Xian Zhang, Li-Mei Wang, Jie Zhao
BACKGROUND: The association between vitamin D receptor (VDR) gene polymorphisms and multiple sclerosis (MS) has been extensively studied, but results were controversial. METHODS: This meta-analysis aimed to confirm whether VDR gene polymorphisms were associated with MS. Meta-analysis on the association between MS and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allelic contrast, recessive, homozygotes and dominant models. Data were extracted by standardized forms and odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model if the results were heterogeneous...
August 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28764147/study-of-vitamin-d-receptor-gene-polymorphism-foki-taqi-and-apai-among-prostate-cancer-patients-in-north-india
#8
Pankaj Ramrao Kambale, Deepa Haldar, B C Kabi, Kalpana Pankaj Kambale
INTRODUCTION: Incidence of prostate cancer is rising worldwide. Multiple factors have been suggested for the aetiology of prostate cancer including ethnic, genetic and diet. Vitamin D (calcitriol) has been shown to have role in cell growth and differentiation and its deficiency is implicated as one of the aetiological factors in prostate cancer. Prostatic epithelial cells express Vitamin D Receptor (VDR) as well as 1α- hydroxylase enzyme that are required for the synthesis of calcitriol and its action...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28749628/circulating-25-hydroxy-vitamin-d-relative-to-vitamin-d-receptor-polymorphism-after-vitamin-d3-supplementation-in-breast-cancer-women-a-randomized-double-blind-controlled-clinical-trial
#9
Houra Mohseni, Seyed Ahmad Hosseini, Reza Amani, Alireza Ekrami, Ahmad Ahmadzadeh, Seyed Mahmoud Latifi
Objective: The influence of vitamin D receptor (VDR) genetic variation on serum 25-hydroxyvitamin D levels [25(OH)D] after vitamin D3 supplementation remains unclear. We aimed to investigate changes of 25(OH)D in a randomized, double-blind, placebo-controlled clinical trial, according to VDR genotype, after provision of vitamin D3 to breast cancer cases for a 2-month period. Methods: Participants were assigned to two treatment arms: placebo (n = 28) and vitamin D3 supplementation (n =28). The supplementation group received 50,000 IU of vitamin D every week for 2 months...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28739681/vitamin-d-receptor-polymorphism-and-cancer-an-update
#10
REVIEW
Vikrant Rai, Joe Abdo, Swati Agrawal, Devendra K Agrawal
BACKGROUND: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. The association of VDR polymorphism with cancer has been reported; however, the literature lacks critical analyses of the studies in last 3 years...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28697775/the-relationship-between-vitamin-d-receptor-gene-polymorphism-and-deciduous-tooth-decay-in-chinese-children
#11
Yuan-Yuan Kong, Jian-Mao Zheng, Wen-Juan Zhang, Qian-Zhou Jiang, Xue-Chao Yang, Miao Yu, Su-Juan Zeng
BACKGROUND: In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children. METHODS: Our study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP. RESULTS: The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1...
July 11, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28665452/genetic-polymorphisms-of-vitamin-d-metabolism-genes-and-serum-level-of-vitamin-d-in-colorectal-cancer
#12
Verônica Marques Vidigal, Pedro Nazareth Aguiar Junior, Tiago Donizetti Silva, Juliana de Oliveira, Célia Aparecida Marques Pimenta, Aledson Vitor Felipe, Nora Manoukian Forones
BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. METHODS: One hundred fifty-two CRC patients and 321 controls were included...
June 19, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28612095/maternal-fetal-vitamin-d-receptor-polymorphisms-significantly-associated-with-preterm-birth
#13
Talya Rosenfeld, Hagit Salem, Gheona Altarescu, Sorina Grisaru-Granovsky, Aharon Tevet, Ruth Birk
PURPOSE: Preterm birth (PTB) is a complex trait with strong genetic background, whose etiology is not fully understood. It was recently suggested that pregnancy duration is affected by fetal genetic variation even more than by the maternal genome. Vitamin D receptor (VDR) is involved in embryonic implantation and fertility. We studied the association between both maternal and neonatal vitamin D receptor (VDR) genetic variation and PTB. METHODS: Maternal and fetal (umbilical cord) DNA was isolated from Jewish Israeli idiopathic preterm newborns (24-36 weeks, n = 146) and control term newborns (>37 weeks, n = 229)...
August 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28607807/immunohistochemical-evaluation-of-vitamin-d-receptor-vdr-expression-in-cutaneous-melanoma-tissues-and-four-vdr-gene-polymorphisms
#14
Francesco La Marra, Giuseppe Stinco, Cinzia Buligan, Giovanni Chiriacò, Diego Serraino, Carla Di Loreto, Sabina Cauci
OBJECTIVE: : Vitamin D receptor (VDR) mediates vitamin D activity. We examined whether VDR expression in excised melanoma tissues is associated with VDR gene (VDR) polymorphisms. METHODS: : We evaluated VDR protein expression (by monoclonal antibody immunostaining), melanoma characteristics, and carriage of VDR-FokI-rs2228570 (C>T),VDR-BsmI-rs1544410 (G>A),VDR-ApaI-rs7975232 (T>G), andVDR-TaqI-rs731236 (T>C) polymorphisms (by restriction fragment length polymorphism)...
May 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28592310/validation-of-the-spanish-version-of-the-amsterdam-preoperative-anxiety-and-information-scale-apais
#15
Manuel Vergara-Romero, José Miguel Morales-Asencio, Angelines Morales-Fernández, Jose Carlos Canca-Sanchez, Francisco Rivas-Ruiz, Jose Antonio Reinaldo-Lapuerta
BACKGROUND: Preoperative anxiety is a frequent and challenging problem with deleterious effects on the development of surgical procedures and postoperative outcomes. To prevent and treat preoperative anxiety effectively, the level of anxiety of patients needs to be assessed through valid and reliable measuring instruments. One such measurement tool is the Amsterdam Preoperative Anxiety and Information Scale (APAIS), of which a Spanish version has not been validated yet. OBJECTIVE: To perform a Spanish cultural adaptation and empirical validation of the APAIS for assessing preoperative anxiety in the Spanish population...
June 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28571837/-prevalence-and-causes-of-pain-after-cataract-surgery-comparison-of-1st-and-2nd-eyes
#16
Y Gayadine-Harricham, T Amzallag
INTRODUCTION: In our practice, patients undergoing bilateral cataract surgery complain of more significant pain after the 2nd eye surgery. The goal of this study was to compare postoperative pain between the 1st and 2nd eyes with cataract surgery under topical anesthesia and to identify the causes of this pain. PATIENTS AND METHODS: We conducted a prospective observational study between May and September 2015. We included 69 consecutive adults scheduled for bilateral cataract surgery under topical anesthesia within 2 months by the same surgeon...
May 29, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28527290/association-of-polymorphic-variants-of-ptpn22-tnf-and-vdr-genes-in-children-with-lupus-nephritis-a-study-in-colombian-family-triads
#17
Gloria Garavito, Eduardo Egea, Luis Fang, Clara Malagón, Carlos Olmos, Luz González, Pilar Guarnizo, Gustavo Aroca, Guillermo López, Antonio Iglesias
INTRODUCTION: Systemic lupus erythematosus is an autoimmune disease in which the severity varies according to race, sex and age of onset. This variation is also observed in the genetic markers associated with the disease, including PTPN22, VDR and TNF genes. The genetic stratification in different populations worldwide can influence the variability. OBJECTIVE: To analyze the heritability of PTPN22, VDR and TNF genetic variants and their association with pediatric lupus nephritis in Colombian families...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28460554/serum-levels-and-apai-polymorphism-of-insulin-like-growth-factor-2-on-intrauterine-growth-restriction-infants
#18
Monica G Hăşmăşanu, Melinda Baizat, Lucia Maria Procopciuc, Ligia Blaga, Mădălina A Văleanu, Tudor C Drugan, Gabriela C Zaharie, Sorana D Bolboacă
PURPOSE: The aim of our study was to evaluate the IGF2 and IGF2R plasmatic level and IGF2-ApaI polymorphism on infants with intrauterine growth restriction (IUGR). MATERIALS AND METHODS: A transversal study was conducted at the Neonatology Ward of the Gynecology Clinic I, Emergency Hospital Cluj-Napoca on neonates with IUGR who were discharged during June 2014 and June 2015. The serum levels of IGF2 and IGF2R were obtained by using ELISA method and IGF2-ApaI polymorphism by taking PCR-RFLP analysis...
May 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28446629/vitamin-d-receptor-and-megalin-gene-polymorphisms-are-associated-with-longitudinal-cognitive-change-among-african-american-urban-adults
#19
May A Beydoun, Salman M Tajuddin, Greg A Dore, Jose-Atilio Canas, Hind A Beydoun, Michele K Evans, Alan B Zonderman
Background: The link between longitudinal cognitive change and polymorphisms in the vitamin D receptor (VDR) and MEGALIN [or LDL receptor-related protein 2 (LRP2)] genes remains unclear, particularly among African-American (AA) adults.Objectives: We aimed to evaluate associations of single nucleotide polymorphisms (SNPs) for VDR [rs11568820 (Cdx-2:T/C), rs1544410 (BsmI:G/A), rs7975232 (ApaI:A/C), rs731236 (TaqI:G/A)] and LRP2 [rs3755166:G/A,rs2075252:C/T, rs2228171:C/T] genes with longitudinal cognitive performance change in various domains of cognition...
June 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28426999/emotional-intelligence-and-affective-events-in-nurse-education-a-narrative-review
#20
REVIEW
Gillian M Lewis, Christine Neville, Neal M Ashkanasy
OBJECTIVE: To investigate the current state of knowledge about emotional intelligence and affective events that arise during nursing students' clinical placement experiences. DESIGN: Narrative literature review. DATA SOURCES: CINAHL, MEDLINE, PsycINFO, Scopus, Web of Science, ERIC and APAIS-Health databases published in English between 1990 and 2016. REVIEW METHODS: Data extraction from and constant comparative analysis of ten (10) research articles...
June 2017: Nurse Education Today
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