keyword
MENU ▼
Read by QxMD icon Read
search

diabetes cortisol

keyword
https://www.readbyqxmd.com/read/28007534/fkbp5-polymorphism-is-associated-with-insulin-resistance-in-children-and-adolescents-with-obesity
#1
Marta Fichna, Izabela Krzyśko-Pieczka, Magdalena Żurawek, Bogda Skowrońska, Danuta Januszkiewicz-Lewandowska, Piotr Fichna
OBJECTIVE: Since metabolic syndrome shares several clinical features with hypercortisolism, it was hypothesised that genes altering individual glucocorticoid (GC) sensitivity might be implicated in pathogenesis of obesity and its adverse outcomes. FKBP5 gene encodes a chaperon protein in the GC receptor (GR) complex, which modulates steroid action upon target genes. Its functional variant, rs1360780, may enhance FKBP5 gene transcription, affect GR signalling and thereby influence the hypothalamo-pituitary-adrenal axis...
December 19, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28000236/optimism-moderates-psychophysiological-responses-to-stress-in-older-people-with-type-2-diabetes
#2
S Puig-Perez, R A Hackett, A Salvador, A Steptoe
Optimism is thought to be beneficial for health, and these effects may be mediated through modifications in psychophysiological stress reactivity. Type 2 diabetes (T2D) is associated with reduced cardiovascular responses to stress and heightened cortisol over the day. This study assessed the relationships between optimism, stress responsivity, and daily cortisol output in people with T2D. A total of 140 participants with T2D were exposed to laboratory stress. Heart rate (HR), systolic (SBP), diastolic blood pressure (DBP), and cortisol were measured throughout the session...
December 21, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27997608/effect-of-peripheral-electrical-stimulation-pes-on-nocturnal-blood-glucose-in-type-2-diabetes-a-randomized-crossover-pilot-study
#3
Merav Catalogna, Keren Doenyas-Barak, Roi Sagi, Ramzia Abu-Hamad, Uri Nevo, Eshel Ben-Jacob, Shai Efrati
BACKGROUND: Regulation of hepatic glucose production has been a target for antidiabetic drug development, due to its major contribution to glucose homeostasis. Previous pre-clinical study demonstrated that peripheral electrical stimulation (PES) may stimulate glucose utilization and improve hepatic insulin sensitivity. The aim of the present study was to evaluate safety, tolerability, and the glucose-lowering effect of this approach in patients with type 2 diabetes (T2DM). METHODS: Twelve patients with T2DM were recruited for an open label, interventional, randomized trial...
2016: PloS One
https://www.readbyqxmd.com/read/27992961/concomitant-alterations-of-metabolic-parameters-cardiovascular-risk-factors-and-altered-cortisol-secretion-in-patients-with-adrenal-incidentalomas-during-prolonged-follow-up
#4
Labrini Papanastasiou, Krystallenia Ι Alexandraki, Ioannis I Androulakis, Stelios Fountoulakis, Theodora Kounadi, Athina Markou, Vaios Tsiavos, Christianna Samara, Theodoros G Papaioannou, George Piaditis, Gregory Kaltsas
OBJECTIVE: Adrenal incidentalomas (AI) are associated with metabolic and hormonal abnormalities, most commonly autonomous cortisol secretion (ACS). Data regarding alterations of insulin resistance (IR), and ACS after prolonged follow-up are limited. We investigated the evolution of IR, cortisol secretion and ACS development in patients with AI during prolonged follow-up. DESIGN: Prospective study in a tertiary hospital. PATIENTS AND MEASUREMENTS: Seventy-one patients with AI, (51 non-functioning [NFAI], 20 ACS), and 5...
December 19, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27987236/evaluation-of-the-counter-regulatory-responses-to-hypoglycemia-in-patients-with-type-1-diabetes-during-opiate-receptor-blockade-with-naltrexone
#5
Sarita Naik, Renata Belfort-DeAguiar, Anne-Sophie Sejling, Barbara Szepietowska, Robert S Sherwin
AIMS: Hypoglycemia is the major limiting factor in achieving optimal glycemic control in people with type 1 diabetes (T1DM), especially intensively treated patients with impaired glucose counterregulation during hypoglycemia. Naloxone, an opiate receptor blocker, has been reported to enhance the acute counterregulatory response to hypoglycemia when administered intravenously in humans. The current study was undertaken to investigate if the oral formulation of the long acting opiate antagonist, naltrexone, could have a similar effect, and thus might be useful therapeutically in T1DM patients with a high risk for hypoglycemia...
December 17, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27936852/racial-ethnic-disparities-in-the-risk-of-posttraumatic-stress-disorder-symptoms-among-mothers-of-children-diagnosed-with-cancer-and-type-1-diabetes-mellitus
#6
Leilani Greening, Laura Stoppelbein, Kara Cheek
OBJECTIVE: Research findings have indicated that mothers of children diagnosed with life-threatening illnesses can be at risk for posttraumatic stress disorder (PTSD) symptoms (PTSS), with African American mothers being especially vulnerable because of evidence suggesting higher rates of PTSD among both African Americans and women. Race/ethnicity, past trauma exposure and the interaction of these variables were evaluated as risk factors for PTSS, depression, and state and trait anxiety among African American and Caucasian mothers of chronically ill children...
December 12, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27932409/increased-prevalence-of-obstructive-sleep-apnea-in-patients-with-cushing-s-syndrome-compared-to-weight-and-age-matched-controls
#7
Feyzi Gokosmanoglu, Aygül Güzel, Elif Kilic Kan, Hulusi Atmaca
OBJECTIVE: Diabetes mellitus and obesity are well-known risk factors associated with obstructive sleep apnea(OSA). Cushing's syndrome (CS) is also characterised by obesity and diabetes mellitus. However, the association between CS and OSA remains unclear. Therefore, we investigated the possible associations between CS and OSA in this study. PATIENTS AND METHODS: Thirty female patients with newly diagnosed active CS and 30 age-, gender and body mass index (BMI)-matched female controls were included in this study...
December 8, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27913001/cancer-related-fatigue-persistent-pervasive-and-problematic
#8
REVIEW
Lynn H Gerber
Cancer-related fatigue (CRF) is commonly reported by patients with cancer before, during, and after treatment. It is a persistent sense of tiredness that interferes with function, is distressing, and requires monitoring and, possibly, treatment. Fatigue assessment requires objective measures and self-reports, such as Functional Assessment of Cancer Therapy-Fatigue. Significant contributors to CRF include anemia, pain, insomnia, depressive symptoms, and elevated BMI. Elevated inflammatory cytokines, diabetes mellitus, cortisol, and cellular dysregulation have been associated with CRF...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27865406/an-adverse-immune-endocrine-profile-in-patients-with-tuberculosis-and-type-2-diabetes
#9
R Fernández, A Díaz, L D'Attilio, B Bongiovanni, N Santucci, D Bertola, H Besedovsky, A Del Rey, M L Bay, O Bottasso
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27861636/association-between-higher-serum-cortisol-levels-and-decreased-insulin-secretion-in-a-general-population
#10
Aya Kamba, Makoto Daimon, Hiroshi Murakami, Hideyuki Otaka, Kota Matsuki, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Ippei Takahashi, Shigeyuki Nakaji
Glucocorticoids (GCs) are well known to induce insulin resistance. However, the effect of GCs on insulin secretion has not been well characterized under physiological conditions in human. We here evaluated the effect of GCs on insulin secretion/ß-cell function precisely in a physiological condition. A population-based study of 1,071 Japanese individuals enrolled in the 2014 Iwaki study (390 men, 681 women; aged 54.1 ± 15.1 years), those excluded individuals taking medication for diabetes or steroid treatment, were enrolled in the present study...
2016: PloS One
https://www.readbyqxmd.com/read/27860160/effect-of-one-week-of-cpap-treatment-of-obstructive-sleep-apnoea-on-24-hour-profiles-of-glucose-insulin-and-counter-regulatory-hormones-in-type-2-diabetes
#11
Babak Mokhlesi, Daniela Grimaldi, Guglielmo Beccuti, Eve Van Cauter
Studies examining the impact of CPAP treatment on glycaemic control have yielded conflicting results, partly because of insufficient nightly CPAP use. We examined the 24-hour profiles of glucose, insulin and counter-regulatory hormones in 12 subjects with type 2 diabetes and OSA before and after 1 week of effective in-laboratory CPAP therapy over an entire 8-hour night thus ensuring optimal CPAP compliance. Blood samples were collected every 15 to 30 minutes for 24 hours under controlled conditions. The 24-hour mean glucose decreased from 153...
November 17, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27800649/effects-of-dpp-4-inhibitor-linagliptin-and-glp-1-receptor-agonist-liraglutide-on-physiological-response-to-hypoglycemia-in-japanese-subjects-with-type-2-diabetes-a-randomized-open-label-2-arm-parallel-comparative-exploratory-trial
#12
Daisuke Yabe, Takashi Eto, Masanari Shiramoto, Shin Irie, Kenta Murotani, Yusuke Seino, Hitoshi Kuwata, Takeshi Kurose, Susumu Seino, Bo Ahren, Yutaka Seino
Dipeptidyl peptidase-4 (DPP-4) inhibitors reduces the risk of hypoglycemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counterregulatory hormone responses to hypoglycemia were evaluated and compared with those of the GLP-1 receptor agonist liraglutide in a multi-center, randomized, open-label, 2 arm parallel comparative, exploratory trial...
November 1, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27792263/the-prevalence-of-impaired-glucose-regulation-in-anxiety-disorder-patients-and-the-relationship-with-hypothalamic-pituitary-adrenal-axis-and-hypothalamic-pituitary-thyroid-axis-activity
#13
Yaling Zhou, Zaiquan Dong, Ruhan A, Zongbing Liao, Jing Guo, Cancan Liu, Xueli Sun
OBJECTIVE: To investigate the prevalence of impaired glucose regulation (IGR) in patients with anxiety disorders and the relationship with hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid (HPT) axes function. METHODS: From September 2013 to May 2015, a total of 646 patients with anxiety disorders who matched the criteria of the 10(th) revision of the International Statistical Classification of Diseases and Related Health Problems participated in our study, which was conducted in the Psychiatric Inpatient Department of the West China Hospital of Sichuan University...
August 29, 2016: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/27763781/markers-of-atherosclerosis-in-patients-with-cushing-s-syndrome-a-meta-analysis-of-literature-studies
#14
Roberta Lupoli, Pasquale Ambrosino, Anna Tortora, Livia Barba, Gelsy Arianna Lupoli, Matteo Nicola Dario Di Minno
BACKGROUND: Several studies reported an increased cardiovascular (CV) risk in Cushing's syndrome (CS). We performed a meta-analysis on the impact of CS on major markers of atherosclerosis. METHODS: Studies on intima-media thickness (IMT), carotid plaques prevalence and flow-mediated dilation (FMD) in CS patients and controls were searched in the PubMed, Web of Science, Scopus and EMBASE. Differences between cases and controls were expressed as mean difference (MD) with 95% confidence intervals (95%CI) for continuous variables, and as Odds Ratio (OR) with 95%CI for dichotomous variables...
October 20, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27759634/delayed-diagnosis-with-autoimmune-polyglandular-syndrome-type-2-causing-acute-adrenal-crisis-a-case-report
#15
Xiaojing Wang, Fan Ping, Cuijuan Qi, Xinhua Xiao
BACKGROUND: Autoimmune polyglandular syndrome type 2 (APS-2), also known as Schmidt's syndrome, is an uncommon disorder characterized by the coexistence of Addison's disease with thyroid autoimmune disease and/or type 1 diabetes mellitus. Addison's disease as the obligatory component is potentially life-threatening. Unfortunately, the delayed diagnosis of Addison's disease is common owing to its rarity and the nonspecific clinical manifestation. METHODS: Here we reported a case of 38-year-old female patient who presented with 2 years' history of Hashimoto's thyroiditis and received levothyroxine replacement...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27750377/cortisol-dysregulation-the-bidirectional-link-between-stress-depression-and-type-2-diabetes-mellitus
#16
Joshua J Joseph, Sherita H Golden
Controversy exists over the role of stress and depression in the pathophysiology of type 2 diabetes mellitus. Depression has been shown to increase the risk for progressive insulin resistance and incident type 2 diabetes mellitus in multiple studies, whereas the association of stress with diabetes is less clear, owing to differences in study designs and in forms and ascertainment of stress. The biological systems involved in adaptation that mediate the link between stress and physiological functions include the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous and immune systems...
October 17, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27744612/follow-up-of-patients-with-adrenal-incidentaloma-in-accordance-with-the-european-society-of-endocrinology-guidelines-could-we-be-safe
#17
V Morelli, A Scillitani, M Arosio, I Chiodini
Recently, the European Society of Endocrinology (ESE) published new guidelines on the management of adrenal incidentalomas. At the same time Lopez and coworkers published on the Annals of Internal Medicine an important study showing that even patients with non-functioning adrenal tumors have an increased risk of incident diabetes. In consideration of previous data and of the results of the study of Lopez and coworkers, some points emerge from the ESE Guidelines that deserve attention. Firstly, it must be observed that the term "autonomous cortisol secretion," introduced by the ESE Panel in the place of the commonly used "subclinical hypercortisolism," seems questionable, since the guidelines do not suggest determining the adrenocorticotroph hormone levels that could give the certain proof of a truly autonomous cortisol secretion...
October 15, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27710242/metabolic-fingerprints-of-circulating-igf-1-and-the-igf-1-igfbp-3-ratio-a-multifluid-metabolomics-study
#18
Henrike Knacke, Maik Pietzner, Kieu Trinh Do, Werner Römisch-Margl, Gabi Kastenmüller, Uwe Völker, Henry Völzke, Jan Krumsiek, Anna Artati, Henri Wallaschofski, Matthias Nauck, Karsten Suhre, Jerzy Adamski, Nele Friedrich
OBJECTIVE: IGF-1 is known for its various physiological and severe pathophysiological effects on human metabolism; however, underlying molecular mechanisms still remain unsolved. To reveal possible molecular mechanisms mediating these effects, for the first time, we associated serum IGF-1 levels with multifluid untargeted metabolomics data. METHODS: Plasma/urine samples of 995 nondiabetic participants of the Study of Health in Pomerania were characterized by mass spectrometry...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27664051/an-okinawan-based-nordic-diet-improves-anthropometry-metabolic-control-and-health-related-quality-of-life-in-scandinavian-patients-with-type-2-diabetes-a-pilot-trial
#19
Gassan Darwiche, Peter Höglund, Bodil Roth, Ewa Larsson, Trygve Sjöberg, Björn Wohlfart, Stig Steen, Bodil Ohlsson
BACKGROUND: Our hypothesis was that a modified diet would improve blood glucose control with beneficial impact on weight management and overall health in established diabetes. OBJECTIVE: This prospective interventional study investigated the clinical effect of an Okinawan-based Nordic diet on anthropometry, metabolic control, and health-related quality of life (HRQoL) in Scandinavian type 2 diabetes patients. DESIGN: Food was prepared and delivered to 30 type 2 diabetes patients...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27646495/prospective-study-of-hypothalamo-hypophyseal-dysfunction-in-children-and-adolescents-following-traumatic-brain-injury
#20
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
keyword
keyword
103907
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"