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pseudomonas aeruginosa review

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https://www.readbyqxmd.com/read/29789006/outcomes-of-lung-transplantation-in-adults-with-bronchiectasis
#1
Jodie Birch, Syba S Sunny, Katy L M Hester, Gareth Parry, F Kate Gould, John H Dark, Stephen C Clark, Gerard Meachery, James Lordan, Andrew J Fisher, Paul A Corris, Anthony De Soyza
BACKGROUND: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. METHODS: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. RESULTS: Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29780361/challenges-and-promises-for-planning-future-clinical-research-into-bacteriophage-therapy-against-pseudomonas-aeruginosa-in-cystic-fibrosis-an-argumentative-review
#2
REVIEW
Martina Rossitto, Ersilia V Fiscarelli, Paola Rosati
Although early aggressive and prolonged treatment with specific antibiotics can extend survival in patients with cystic fibrosis (CF) colonized by opportunistic Pseudomonas aeruginosa (PA), antibiotics fail to eradicate the infecting multidrug-resistant (MDR) PA strains in CF. Century-long research has suggested treating patients with bacteriophages (phages, prokaryotic viruses) naturally hosted by bacteria. Although the only phage types used in therapy, lytic phages, lyse PA aggregated in biofilm matrix by depolymerase degrading enzymes, how they can effectively, safely, and persistently do so in patients with CF is unclear...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29778213/nitric-oxide-an-old-molecule-with-noble-functions-in-pseudomonas-aeruginosa-biology
#3
Masanori Toyofuku, Sang-Sun Yoon
Pseudomonas aeruginosa, a Gram-negative bacterium, is characterized by its versatility that enables persistent survival under adverse conditions. It can grow on diverse energy sources and readily acquire resistance to antimicrobial agents. As an opportunistic human pathogen, it also causes chronic infections inside the anaerobic mucus airways of cystic fibrosis patients. As a strict respirer, P. aeruginosa can grow by anaerobic nitrate ( [Formula: see text] ) respiration. Nitric oxide (NO) produced as an intermediate during anaerobic respiration exerts many important effects on the biological characteristics of P...
2018: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/29775211/proanthocyanidins-will-they-effectively-restrain-conspicuous-bacterial-strains-devolving-on-urinary-tract-infection
#4
REVIEW
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29770096/canadian-recommendations-for-laboratory-interpretation-of-multiple-or-extensive-drug-resistance-in-clinical-isolates-of-enterobacteriaceae-acinetobacter-species-and-pseudomonas-aeruginosa
#5
G J German, M Gilmour, G Tipples, H J Adam, H Almohri, J Bullard, T Dingle, D Farrell, G Girouard, D Haldane, L Hoang, P N Levett, R Melano, J Minion, R Needle, S N Patel, R Rennie, R C Reyes, J Longtin, M R Mulvey
The goal of this document was to provide Canadian laboratories with a framework for consistent reporting and monitoring of multidrug resistant organisms (MDRO) and extensively drug resistant organisms (XDRO) for common gram-negative pathogens. This is the final edition of the interim recommendations, which were modified after one year of broad consultative review. This edition represents a consensus of peer-reviewed information and was co-authored by the Canadian Public Health Laboratory Network and the Canadian Association of Clinical Microbiology and Infectious Diseases...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29752592/the-rate-of-endophthalmitis-after-pars-plana-vitrectomy-and-its-risk-factors
#6
Seyed Ali Tabatabaei, Mohammad Soleimani, Hadi Vakili, Morteza Naderan, Alireza Lashay, Houshang Faghihi, Mehdi Yaseri
PURPOSE: To study the incidence of endophthalmitis after pars plana vitrectomy, its causative organisms, and visual acuity outcomes. PATIENTS AND METHODS: In this retrospective, comparative study, the medical records of patients with acute-onset postoperative endophthalmitis after pars plana vitrectomy at Farabi Eye Hospital, Tehran, Iran, during a 12-year period between January 2004 and November 2015 were reviewed. To compare the endophthalmitis patients with other cases who underwent pars plana vitrectomy at the same day and also the same operating room, a control group was developed by gathering the data from surgical records...
May 11, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29724436/is-it-safe-to-re-access-sodium-bicarbonate-bottles-for-use-in-minor-surgery
#7
Lindsay Bjornson, Marija Bucevska, Peter Tilley, Cynthia Verchere
BACKGROUND/PURPOSE: Sodium bicarbonate is added to lidocaine to reduce injection pain. In Canada, it is available in vials exceeding the injection volume 100-fold. These are single-use vials that should be disposed of after one access. Some surgeons re-use vials to reduce waste, potentially causing contamination. This study aims to review the safety of sodium bicarbonate and assess alternatives to current practice. METHODS: Strains of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Burkholderia cepacia were used to assess bacterial growth in vials of sodium bicarbonate...
April 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29724384/long-term-azithromycin-therapy-to-reduce-acute-exacerbations-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#8
Nafiseh Naderi, Deborah Assayag, Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi, Zeina Kaddaha, Alexandre Joubert, Isabelle Ouellet, Isabelle Drouin, Pei Zhi Li, Jean Bourbeau
RATIONALE: According to clinical trials, azithromycin taken daily for 1 year, decreased exacerbations of chronic obstructive pulmonary disease (COPD). OBJECTIVES: Effectiveness evaluation of long-term azithromycin to reduce exacerbations in severe COPD patient on optimal therapy in real-life practice. METHODS: We conducted a retrospective observational study of severe COPD patients who were prescribed azithromycin (PA)(250 mg, at least 3 times weekly for at least 6 months)...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29707229/fighting-biofilms-with-lantibiotics-and-other-groups-of-bacteriocins
#9
REVIEW
Harsh Mathur, Des Field, Mary C Rea, Paul D Cotter, Colin Hill, R Paul Ross
Biofilms are sessile communities of bacteria typically embedded in an extracellular polymeric matrix. Bacterial cells embedded in biofilms are inherently recalcitrant to antimicrobials, compared to cells existing in a planktonic state, and are notoriously difficult to eradicate once formed. Avenues to tackle biofilms thus far have largely focussed on attempting to disrupt the initial stages of biofilm formation, including adhesion and maturation of the biofilm. Such an approach is advantageous as the concentrations required to inhibit formation of biofilms are generally much lower than removing a fully established biofilm...
2018: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29692381/current-status-of-community-acquired-pneumonia-in-patients-with-chronic-obstructive-pulmonary-disease
#10
REVIEW
De-Shun Liu, Xiu-Di Han, Xue-Dong Liu
Objective: Worldwide, community-acquired pneumonia (CAP) is a common infection that occurs in older adults, who may have pulmonary comorbidities, including chronic obstructive pulmonary disease (COPD). Although there have been clinical studies on the coexistence of CAP with COPD, there remain some controversial findings. This review presents the current status of COPD in CAP patients, including the disease burden, clinical characteristics, risk factors, microbial etiology, and antibiotic treatment...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29681898/the-versatile-mutational-resistome-of-pseudomonas-aeruginosa
#11
REVIEW
Carla López-Causapé, Gabriel Cabot, Ester Del Barrio-Tofiño, Antonio Oliver
One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for developing antimicrobial resistance to nearly all available antipseudomonal agents through the selection of chromosomal mutations, leading to the failure of the treatment of severe hospital-acquired or chronic infections. Recent whole-genome sequencing (WGS) data obtained from in vitro assays on the evolution of antibiotic resistance, in vivo monitoring of antimicrobial resistance development, analysis of sequential cystic fibrosis isolates, and characterization of widespread epidemic high-risk clones have provided new insights into the evolutionary dynamics and mechanisms of P...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29671219/ceftazidime-avibactam-a-review-in-the-treatment-of-serious-gram-negative-bacterial-infections
#12
Matt Shirley
Ceftazidime-avibactam (Zavicefta® ) is an intravenously administered combination of the third-generation cephalosporin ceftazidime and the novel, non-β-lactam β-lactamase inhibitor avibactam. In the EU, ceftazidime-avibactam is approved for the treatment of adults with complicated urinary tract infections (cUTIs) [including pyelonephritis], complicated intra-abdominal infections (cIAIs), hospital-acquired pneumonia (HAP) [including ventilator-associated pneumonia (VAP)], and other infections caused by aerobic Gram-negative organisms in patients with limited treatment options...
April 18, 2018: Drugs
https://www.readbyqxmd.com/read/29669956/nosocomial-pneumonia-search-for-an-empiric-and-effective-antibiotic-regimen-in-high-burden-tertiary-care-centre
#13
Nitin Gupta, Manish Soneja, Yogiraj Ray, Monalisa Sahu, Kutty Sharada Vinod, Arti Kapil, Ashutosh Biswas, Naveet Wig, Rita Sood
The clinical practice guidelines on nosocomial pneumonia recommends an empirical regimen that would work in 95% of the patients based on the local antibiogram. The aim of the study was development of an antibiogram for guiding empiric therapy in settings with high prevalence of multi-drug resistant organisms. A retrospective review of electronic health records (e-hospital portal) was done to analyze all respiratory isolates from patients admitted in medical wards and intensive care unit between May 2016 and May 2017...
April 17, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29662672/results-of-a-local-combination-therapy-antibiogram-for-pseudomonas-aeruginosa-isolates-is-double-worth-the-trouble
#14
Matthew Song, Thomas J Dilworth, Erik Munson, Jim Davis, Ramy H Elshaboury
Purpose: To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam agents. Methods: β-lactam-non-susceptible P. aeruginosa isolates recovered from blood, bone, lower respiratory tract, pleural fluid, cerebrospinal fluid, or peritoneal fluid cultures between October 2010 and October 2014 were reviewed from four community hospitals within a single health-system...
November 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29655388/the-prevalence-of-healthcare-associated-infections-in-mainland-china-a-systematic-review-and-meta-analysis
#15
Jiancong Wang, Fangfei Liu, Ermira Tartari, Jianan Huang, Stephan Harbarth, Didier Pittet, Walter Zingg
OBJECTIVETo assess the prevalence of healthcare-associated infections (HAIs) in mainland China.DESIGNSystematic review and meta-analysis.SETTINGAdults and children from secondary and tertiary acute-care hospitals in mainland China.METHODSWe searched PubMed, the China National Knowledge Infrastructure, and Wan Fang for multicenter point-prevalence surveys of acute-care hospitals in mainland China from January 2006 to August 2016. All reports related to HAI, using a point-prevalence methodology and published either in English or Chinese were eligible...
April 15, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29649830/healthcare-associated-infections-after-lower-urinary-tract-endoscopic-surgery-analysis-of-risk-factors-associated-microorganisms-and-patterns-of-antibiotic-resistance
#16
Raquel Sopeña-Sutil, José Medina-Polo, Juan Justo-Quintas, Javier Gil-Moradillo, Lucia Garcia-Gonzalez, Raúl Benítez-Sala, Manuel Alonso-Isa, Alba Lara-Isla, Angel Tejido-Sanchez
OBJECTIVES: To review the incidence of healthcare-associated infections/urinary tract infection (UTI), risk factors, microorganisms isolated and antibiotic resistances in patients who underwent lower urinary tract endoscopic surgery (LUTES) in a tertiary care hospital. METHODS: A prospective observational study was carried out including 1,498 patients who undergo LUTES. Patients with and without UTI after surgery were compared. We analysed infection incidence, risk factors, microorganisms isolated and antibiotic resistances...
April 12, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29644540/molecular-epidemiology-of-carbapenem-resistant-pseudomonas-aeruginosa-in-an-endemic-area-comparison-with-global-data
#17
REVIEW
Theodoros Karampatakis, Charalampos Antachopoulos, Athanassios Tsakris, Emmanuel Roilides
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is an endemic problem in certain countries including Greece. CRPA and multidrug-resistant P. aeruginosa (MDRPA) firstly emerged in our region during the 80s, right after the launch of imipenem and meropenem as therapeutic agents against P. aeruginosa infections. The role of outer membrane protein (Opr) inactivation has been known to contribute to imipenem resistance since many years, while efflux overexpression systems have been mainly associated with meropenem resistance...
April 11, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29643807/antimicrobial-peptides-and-their-therapeutic-potential-for-bacterial-skin-infections-and-wounds
#18
REVIEW
Anja Pfalzgraff, Klaus Brandenburg, Günther Weindl
Alarming data about increasing resistance to conventional antibiotics are reported, while at the same time the development of new antibiotics is stagnating. Skin and soft tissue infections (SSTIs) are mainly caused by the so called ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter species) which belong to the most recalcitrant bacteria and are resistant to almost all common antibiotics. S. aureus and P. aeruginosa are the most frequent pathogens isolated from chronic wounds and increasing resistance to topical antibiotics has become a major issue...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29618488/steroid-sulfatase-inhibition-by-aryl-sulfamates-clinical-progress-mechanism-and-future-prospects
#19
Barry V L Potter
Steroid sulfatase is an emerging drug target for the endocrine therapy of hormone-dependent diseases, catalyzing estrogen sulfate hydrolysis to estrogen. Drug discovery, developing the core aryl O-sulfamate pharmacophore, has led to steroidal and non-steroidal drugs entering numerous clinical trials, with promising results in oncology and women's health. Steroidal estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors and one was developed clinically as an oral estradiol pro-drug and for endometriosis applications...
April 4, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29617698/pseudomonas-aeruginosa-and-klebsiella-pneumoniae-adaptation-to-innate-immune-clearance-mechanisms-in-the-lung
#20
Sebastian A Riquelme, Danielle Ahn, Alice Prince
Many different species of gram-negative bacteria are associated with infection in the lung, causing exacerbations of chronic obstructive pulmonary disease, cystic fibrosis (CF), and ventilator-associated pneumonias. These airway pathogens must adapt to common host clearance mechanisms that include killing by antimicrobial peptides, antibiotics, oxidative stress, and phagocytosis by leukocytes. Bacterial adaptation to the host is often evident phenotypically, with increased extracellular polysaccharide production characteristic of some biofilm-associated organisms...
April 4, 2018: Journal of Innate Immunity
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