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pseudomonas aeruginosa review

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https://www.readbyqxmd.com/read/27907224/single-versus-combination-intravenous-anti-pseudomonal-antibiotic-therapy-for-people-with-cystic-fibrosis
#1
REVIEW
Heather E Elphick, Alison Scott
BACKGROUND: Choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and reduction of drug-related toxicity. Current evidence does not provide a clear answer and the use of intravenous antibiotic therapy in cystic fibrosis requires further evaluation...
December 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#2
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27876274/are-there-any-ways-around-the-exposure-limiting-nephrotoxicity-of-the-polymyxins
#3
Jason M Pogue, Jessica K Ortwine, Keith S Kaye
The polymyxins (colistin and polymyxin B) have emerged over the past 20 years as essential antibacterial agents that often are the only remaining active class against troublesome multidrug-resistant Gram-negative bacilli such as carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacteriaceae. The utility of this class is limited by its dose-dependent nephrotoxicity, which can occur in more than one-half of patients receiving therapy with either agent. Strategies are urgently needed to optimise the use of this class of agents to ensure optimal activity while minimising the treatment-limiting nephrotoxicity...
November 11, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27865626/synergistic-combinations-of-polymyxins
#4
Justin R Lenhard, Roger L Nation, Brian T Tsuji
The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011-2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii...
October 24, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27859825/do-children-with-cystic-fibrosis-receiving-outreach-care-have-poorer-clinical-outcomes-than-those-treated-at-a-specialist-cystic-fibrosis-centre
#5
Heinrich C Weber, Philip F Robinson, Nicole Saxby, Sean A Beggs, Ingrid Els, Rodney I Ehrlich
INTRODUCTION: Although cystic fibrosis (CF) centre care is generally considered ideal, children living in regional Australia receive outreach care supported by the academic CF centres. METHODS: This is a retrospective database review of children with CF treated at the Royal Children's Hospital in Melbourne and its outreach clinics in Albury (Victoria), and Tasmania. The aim was to compare the outcomes of children with CF managed at an academic centre with that of outreach care, using lung function, nutritional status and Pseudomonas aeruginosa colonisation...
November 17, 2016: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/27823913/-cutaneous-lesions-during-hot-tub-hypersensitivity-pneumonitis-pseudomonas-folliculitis%C3%A2
#6
N Sokolowsky, L Rolland, M-A Vandenhende, J-Y Colin, F Laurent, P Morlat, F Bonnet, M Beylot-Barry
BACKGROUND: Interstitial lung disease, cutaneous rash and elevated serum angiotensin converting enzyme (ACE) may suggest diagnoses other than sarcoidosis. PATIENTS AND METHODS: A 58-year-old man had presented dyspnoea for 2 years with increased angiotensin-converting enzyme, as well as an interstitial syndrome and micronodules. The possibility of sarcoidosis was raised. Systemic corticosteroids resulted in improvement of the dyspnoea although it recurred on dose reduction...
November 4, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27821456/carbapenem-resistant-pseudomonas-aeruginosa-bacteremia-risk-factors-for-mortality-and-microbiologic-treatment-failure
#7
Deanna J Buehrle, Ryan K Shields, Lloyd G Clarke, Brian A Potoski, Cornelius J Clancy, M Hong Nguyen
We reviewed 37 patients treated for bacteremia due to carbapenem-resistant Pseudomonas aeruginosa (CR-Pa). Although 65% of isolates were multiple-drug resistant, therapeutic options were available as all were susceptible to ≥1 antibiotic. Ninety-two percent of patients received active antimicrobial therapy, but only 57% received early active therapy (within 48 hours). Fourteen-day mortality was 19%. Microbiologic failure occurred in 29%. Pitt bacteremia score (P=0.046) and delayed active therapy (P=0.027) were predictive of death and microbiologic failure, respectively...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27806928/the-intrinsic-resistance-of-bacteria
#8
Zhang Gang, Feng Jie
Antibiotic resistance is often considered to be a trait acquired by previously susceptible bacteria, on the basis of which can be attributed to the horizontal acquisition of new genes or the occurrence of spontaneous mutation. In addition to acquired resistance, bacteria have a trait of intrinsic resistance to different classes of antibiotics. An intrinsic resistance gene is involved in intrinsic resistance, and its presence in bacterial strains is independent of previous antibiotic exposure and is not caused by horizontal gene transfer...
October 20, 2016: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/27806892/necrotizing-otitis-externa-diagnosis-treatment-and-outcome-in-a-case-series
#9
Eran Glikson, Doron Sagiv, Michael Wolf, Yisgav Shapira
We reviewed 25 cases of patients diagnosed with necrotizing otitis externa in our tertiary university-affiliated medical center between 2009 and 2015. Mean overall hospitalization duration was 14.52days, 95% of the patients showed specific seasonal incidence. Mean duration of symptoms prior to hospitalization was 6weeks and the duration correlated with outcome. Only 8% of the patients presented with cranial neuropathies; however, this presentation correlated with adverse outcome. Pseudomonas aeruginosa was the main causative organism (50%), with a 30% multidrug-resistance rate...
October 18, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27790211/modular-approach-to-select-bacteriophages-targeting-pseudomonas-aeruginosa-for-their-application-to-children-suffering-with-cystic-fibrosis
#10
REVIEW
Victor Krylov, Olga Shaburova, Elena Pleteneva, Maria Bourkaltseva, Sergey Krylov, Alla Kaplan, Elena Chesnokova, Leonid Kulakov, Damian Magill, Olga Polygach
This review discusses the potential application of bacterial viruses (phage therapy) toward the eradication of antibiotic resistant Pseudomonas aeruginosa in children with cystic fibrosis (CF). In this regard, several potential relationships between bacteria and their bacteriophages are considered. The most important aspect that must be addressed with respect to phage therapy of bacterial infections in the lungs of CF patients is in ensuring the continuity of treatment in light of the continual occurrence of resistant bacteria...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27758704/plant-derived-compounds-as-potential-source-of-novel-anti-biofilm-agents-against-pseudomonas-aeruginosa
#11
Pooi Yin Chung
Pseudomonas aeruginosa is the most common Gram-negative bacterium associated with nosocomial and life-threatening chronic infections in cystic fibrosis patients. This pathogen is well-known for its ability to attach to surfaces of indwelling medical devices to form biofilms, which consist of a regular array of extracellular polymers. Tenaciously bound to the surface of devices and inherently resilient to antibiotic treatment, P. aeruginosa poses a serious threat in clinical medicine and contributes to the persistence of chronic infections...
October 19, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27746159/modulation-of-host-defence-against-bacterial-and-viral-infections-by-omega-3-polyunsaturated-fatty-acids
#12
REVIEW
Marie-Odile Husson, Delphine Ley, Céline Portal, Madeleine Gottrand, Thomas Hueso, Jean-Luc Desseyn, Frédéric Gottrand
OBJECTIVES: Although n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) are used widely in the treatment of chronic inflammatory diseases, their effect in infectious disease requires a particular attention. METHODS: The present article discusses their anti-inflammatory and immune properties involved in the host defence and presents a systematic review of the effects of their oral administration on the prevention and outcome of experimental and clinical infections...
December 2016: Journal of Infection
https://www.readbyqxmd.com/read/27743202/updates-in-the-management-of-cephalosporin-resistant-gram-negative-bacteria
#13
Andre Arizpe, Kelly R Reveles, Shrina D Patel, Samuel L Aitken
Resistance to cephalosporins is now common among Gram-negative bacterial infections, including those caused by the Enterobacteriaceae and Pseudomonas aeruginosa, posing a major threat to public health. As resistance to the traditional drugs of choice for these infections, carbapenems, has also become increasingly common, interest in cefepime and piperacillin-tazobactam as carbapenem-sparing alternatives has increased. Additionally, the availability of the novel β-lactam-β-lactamase inhibitor combinations ceftolozane-tazobactam and ceftazidime-avibactam has added to the antimicrobial armamentarium available to treat these multidrug-resistant infections...
December 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27735846/inhalable-antimicrobials-for-treatment-of-bacterial-biofilm-associated-sinusitis-in-cystic-fibrosis-patients-challenges-and-drug-delivery-approaches
#14
Sylvia Natalie Kłodzińska, Petra Alexandra Priemel, Thomas Rades, Hanne Mørck Nielsen
Bacterial biofilm-associated chronic sinusitis in cystic fibrosis (CF) patients caused by Pseudomonas aeruginosa infections and the lack of available treatments for such infections constitute a critical aspect of CF disease management. Currently, inhalation therapies to combat P. aeruginosa infections in CF patients are focused mainly on the delivery of antimicrobials to the lower respiratory tract, disregarding the sinuses. However, the sinuses constitute a reservoir for P. aeruginosa growth, leading to re-infection of the lungs, even after clearing an initial lung infection...
October 9, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27733304/solid-organ-transplant-antibiograms-an-opportunity-for-antimicrobial-stewardship
#15
Rossana Rosa, Jacques Simkins, Jose F Camargo, Octavio Martinez, Lilian M Abbo
OBJECTIVES: We aimed to compare the antimicrobial susceptibility percentages in blood and urine bacterial isolates recovered from solid organ transplant (SOT) recipients with those reported in the hospital-wide antibiogram. METHODS: Retrospective review of the antimicrobial susceptibilities of bacterial isolates recovered from SOT recipients at a 1550-bed hospital over a 2-year period. Antibiograms were categorized by anatomic site (blood and urine). Percentage of bacterial susceptibilities to specific antibiotics were compared with the hospital-wide antibiogram...
August 26, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27730639/insights-into-host-pathogen-interactions-from-state-of-the-art-animal-models-of-respiratory-pseudomonas-aeruginosa-infections
#16
REVIEW
Anne Lorenz, Vinay Pawar, Susanne Häussler, Siegfried Weiss
Pseudomonas aeruginosa is an important opportunistic pathogen that can cause acute respiratory infections in immunocompetent patients or chronic infections in immunocompromised individuals and in patients with cystic fibrosis. When acquiring the chronic infection state, bacteria are encapsulated within biofilm structures enabling them to withstand diverse environmental assaults, including immune reactions and antimicrobial therapy. Understanding the molecular interactions within the bacteria, as well as with the host or other bacteria, is essential for developing innovative treatment strategies...
November 2016: FEBS Letters
https://www.readbyqxmd.com/read/27718217/animal-models-of-implant-related-low-grade-infections-a-twenty-year-review
#17
Arianna Barbara Lovati, Marta Bottagisio, Elena de Vecchi, Enrico Gallazzi, Lorenzo Drago
The demand for joint replacement and surgical treatment is continuously increasing, thus representing a clinical burden and a cost for the healthcare system. Among several pathogens involved in implant-related infections, staphylococci account for the two-thirds of clinically isolated bacteria. Despite most of them are highly virulent microorganisms (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa), low virulent bacteria (Staphylococcus epidermidis, Propionibacterium acnes) are responsible for delayed, low-grade infections without specific clinical signs and hardly distinguishable from aseptic prosthetic failure...
October 9, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27716406/pseudomonas-mendocina-native-valve-infective-endocarditis-a-case-report
#18
Glenn J Rapsinski, Jina Makadia, Nitin Bhanot, Zaw Min
BACKGROUND: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. CASE PRESENTATION: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis...
October 4, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27713884/resistance-mechanisms
#19
Yasemin Cag, Hulya Caskurlu, Yanyan Fan, Bin Cao, Haluk Vahaboglu
By definition, the terms sepsis and septic shock refer to a potentially fatal infectious state in which the early administration of an effective antibiotic is the most significant determinant of the outcome. Because of the global spread of resistant bacteria, the efficacy of antibiotics has been severely compromised. S. pneumonia, Escherichia coli (E. coli), Klebsiella, Acinetobacter, and Pseudomonas are the predominant pathogens of sepsis and septic shock. It is common for E. coli, Klebsiella, Acinetobacter and Pseudomonas to be resistant to multiple drugs...
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27692977/comparison-of-inhaled-antibiotics-for-the-treatment-of-chronic-pseudomonas-aeruginosa-lung-infection-in-patients-with-cystic-fibrosis-systematic-literature-review-and-network-meta-analysis
#20
J Stuart Elborn, Anne-Lise Vataire, Ayako Fukushima, Samuel Aballea, Amine Khemiri, Curtis Moore, Goran Medic, Michiel E H Hemels
PURPOSE: In Europe, 4 inhaled antibiotics (tobramycin, colistimethate sodium, aztreonam, and levofloxacin) are currently approved for the treatment of chronic Pseudomonas aeruginosa lung infection in patients with cystic fibrosis (CF). Levofloxacin inhalation solution (LIS) is the most recently approved inhaled antibiotic for adult patients with CF. A systematic literature review and Bayesian network meta-analysis (NMA) was conducted to compare the relative short-term (4 weeks) and long-term (24 weeks) outcomes of these inhaled antibiotics versus LIS...
September 28, 2016: Clinical Therapeutics
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