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https://www.readbyqxmd.com/read/29443747/supraglottoplasty-in-neonates-and-infants-a-radiofrequency-ablation-approach
#1
Shilei Pu, Hongming Xu, Xiaoyan Li
BACKGROUND: Supraglottoplasty is the mainstay of surgical treatment for laryngomalacia. A novel supraglottoplasty surgical technique is needed to achieve better efficacy. The purpose of this study was to introduce modified microscopic radiofrequency ablation supraglottoplasty (MMRAS) for the treatment of congenital laryngomalacia and to evaluate the outcome and effectiveness of this novel approach. METHODS: Seventeen children with severe laryngomalacia who underwent MMRAS were studied retrospectively...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29439417/recent-advances-in-antibacterial-and-antiendotoxic-peptides-or-proteins-from-marine-resources
#2
REVIEW
Zhenlong Wang, Xiumin Wang, Jianhua Wang
Infectious diseases caused by Gram-negative bacteria and sepsis induced by lipopolysaccharide (LPS) pose a major threat to humans and animals and cause millions of deaths each year. Marine organisms are a valuable resource library of bioactive products with huge medicinal potential. Among them, antibacterial and antiendotoxic peptides or proteins, which are composed of metabolically tolerable residues, are present in many marine species, including marine vertebrates, invertebrates and microorganisms. A lot of studies have reported that these marine peptides and proteins or their derivatives exhibit potent antibacterial activity and antiendotoxic activity in vitro and in vivo...
February 10, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29433688/synergism-of-prenylflavonoids-from-morus-alba-root-bark-against-clinical-mrsa-isolates
#3
Guo-Ying Zuo, Cui-Xian Yang, Jun Han, Yu-Qing Li, Gen-Chun Wang
BACKGROUND: Clinical methicillin-resistant Staphylococcus aureus (MRSA) is a thorny problem in current anti-infective therapeutics and a challenge of new drug development. Plant prenylflavonoids possess anti-MRSA activity, but few of the prenylflavonoids have been reported the synergistic anti-MRSA effect when they are used in combination with conventional antibacterial agents. PURPOSE: This study deals with anti-MRSA activity of four prenylflavonoids from the root bark of Morus alba and their synergism with 11 conventional antibacterial agents...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29432677/multifunctional-biomaterial-coating-based-on-bio-inspired-polyphosphate-and-lysozyme-supramolecular-nanofilm
#4
Xinyuan Xu, Dongyue Zhang, Shangwei Gao, Toshikazu Shiba, Quan Yuan, Kai Cheng, Hong Tan, Jianshu Li
Current implant materials have widespread clinical applications together with some disadvantages, the majority of which are easily to induce infection and hardly to exhibit biocompatibility. To efficiently improve their properties, the development of interface multifunctional modification in a simple, universal and environment benign approach becomes a critical challenge and appeals numerous attention of scientists. In this study, a lysozyme-polyphosphate composite coating was fabricated for titanium(Ti)-based biomaterial in order to obtain multifunctional surface...
February 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29429458/-burkholderia-cepacia-infection-in-children-a-clinical-analysis-of-16-cases
#5
Fang Peng, Li-Li Zhong, Xiao-Juan Lin, Min Chen, Miao Zhou
OBJECTIVE: To investigate the distribution characteristics and clinical features of Burkholderia cepacia infection in children. METHODS: A retrospective analysis was performed for the clinical data of 16 children with Burkholderia cepacia infection who were hospitalized between June 2012 and September 2017. RESULTS: All 16 children with Burkholderia cepacia infection were sporadic cases. A total of 16 strains of Burkholderia cepacia were isolated, among which 8 were detected by sputum culture, 5 were detected by blood culture, 2 were detected by tracheal intubation tip culture, and 1 was detected by lung biopsy culture...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29426873/suppression-of-staphylococcus-aureus-biofilm-formation-and-virulence-by-a-benzimidazole-derivative-um-c162
#6
Cin Kong, Chin-Fei Chee, Katharina Richter, Nicky Thomas, Noorsaadah Abd Rahman, Sheila Nathan
Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazole derivative, UM-C162, which rescued nematodes from a S...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426804/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biologic-therapies-an-infectious-diseases-perspective-cell-surface-receptors-and-associated-signaling-pathways
#7
REVIEW
J Aguilar-Company, M Fernández-Ruiz, R García-Campelo, A C Garrido-Castro, I Ruiz-Camps
BACKGROUND: The present review is part of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biologic therapies. AIMS: To review, from an infectious diseases perspective, the safety profile of therapies targeting cell surface receptors and associated signaling pathways among cancer patients and to suggest preventive recommendations...
February 6, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29425164/association-of-alpha-tocopherol-and-ag-sulfadiazine-chitosan-oleate-nanocarriers-in-bioactive-dressings-supporting-platelet-lysate-application-to-skin-wounds
#8
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Eleonora Dellera, Alessandro Invernizzi, Cinzia Boselli, Antonia Icaro Cornaglia, Claudia Del Fante, Cesare Perotti, Barbara Vigani, Federica Riva, Carla Caramella, Franca Ferrari
Chitosan oleate was previously proposed to encapsulate in nanocarriers some poorly soluble molecules aimed to wound therapy, such as the anti-infective silver sulfadiazine, and the antioxidant α tocopherol. Because nanocarriers need a suitable formulation to be administered to wounds, in the present paper, these previously developed nanocarriers were loaded into freeze dried dressings based on chitosan glutamate. These were proposed as bioactive dressings aimed to support the application to wounds of platelet lysate, a hemoderivative rich in growth factors...
February 9, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29425049/polysaccharide-sub-microcarrier-for-improved-pulmonary-delivery-of-poorly-soluble-anti-infective-ciprofloxacin-preparation-characterization-and-influence-of-size-on-cellular-uptake
#9
Duy-Khiet Ho, Ana Costa, Chiara De Rossi, Cristiane de Souza Carvalho-Wodarz, Brigitta Loretz, Claus-Michael Lehr
The majority of the currently used and developed anti-infectives are poorly water-soluble molecules. The poor solubility might lead to limited bioavailability and pharmacological action of the drug. Novel pharmaceutical materials have thus been designed to solve those problems and improve drug delivery. In this study, we propose a facile method to produce sub-microcarriers (sMCs) by electrostatic gelation of anionic ß-Cyclodextrin (aß-CD) and chitosan. The average hydrodynamic size ranged from 400-900 nm by carefully adjusting polymer concentrations and N/C ratio...
February 9, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29412643/the-expanding-diversity-of-mycobacterium-tuberculosis-drug-targets
#10
Samantha Wellington, Deborah T Hung
After decades of relative inactivity, a large increase in efforts to discover antitubercular therapeutics has brought insights into the biology of Mycobacterium tuberculosis (Mtb) and promising new drugs such as bedaquiline, which inhibits ATP synthase, and the nitroimidazoles delamanid and pretomanid, which inhibit both mycolic acid synthesis and energy production. Despite these advances, the drug discovery pipeline remains underpopulated. The field desperately needs compounds with novel mechanisms of action capable of inhibiting multi- and extensively drug -resistant Mtb (M/XDR-TB) and, potentially, nonreplicating Mtb with the hope of shortening the duration of required therapy...
February 15, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29407045/antibiofilm-activity-of-bioactive-hop-compounds-humulone-lupulone-and-xanthohumol-toward-susceptible-and-resistant-staphylococci
#11
Katerina Bogdanova, Magdalena Röderova, Milan Kolar, Katerina Langova, Martin Dusek, Petr Jost, Klara Kubelkova, Pavel Bostik, Jana Olsovska
Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials, and staphylococci are recognized as the most frequent cause of biofilm-associated infections. The hop plant (Humulus lupulus L.) contains substances that have been determined to act as anti-infective agents against bacteria, mainly in planktonic form. Therefore, we decided to investigate the antibiofilm properties of Humulus lupulus L.-derived compounds (humulone, lupulone and xanthohumol) against a selected group of Staphylococcus spp...
January 30, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29399578/anti-infective-potential-of-catechins-and-their-derivatives-against-viral-hepatitis
#12
REVIEW
Jae-Min Song
Polyphenols including catechins from green tea ( Camellia sinensis ) have been reported to have anti-infective activities against a broad spectrum of viruses and other pathogens. During the last two decades, antiviral activities of catechins with different modes of action have been demonstrated on diverse families of viruses, such as human immunodeficiency virus, Herpes simplex virus, influenza virus, hepatitis B and C virus. In this study, we focused on the antiviral properties of catechins and their derivatives against viral hepatitis which have become a key public health issue due to their serious impact on human health with liver diseases...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29396496/metals-enhance-the-killing-of-bacteria-by-bacteriophage-in-human-blood
#13
Li Ma, Sabrina I Green, Barbara W Trautner, Robert F Ramig, Anthony W Maresso
Multidrug-resistant bacterial pathogens are a major medical concern. E. coli, particularly the pathotype extraintestinal pathogenic E. coli (ExPEC), is a leading cause of bloodstream infections. As natural parasites of bacteria, bacteriophages are considered a possible solution to treat patients infected with antibiotic resistant strains of bacteria. However, the development of phage as an anti-infective therapeutic is hampered by limited knowledge of the physiologic factors that influence their properties in complex mammalian environments such as blood...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29395886/-drug-administration-to-pediatric-patients-evaluation-of-the-nurses-preparation-habits-in-pediatric-units
#14
S Ménétré, M Weber, M Socha, S Le Tacon, I May, C Schweitzer, B Demoré
In hospitals, the nursing staff is often confronted with the problem of the preparation and administration of drugs for their pediatric patients because of the lack of indication, pediatric dosage, and appropriate galenic form. The goal of this study was to give an overview of the nurses' preparation habits in pediatric units and highlight their daily problems. This single-center prospective study was conducted through an observation of the nursing staff during the drug preparation process in medicine, surgery and intensive care units...
January 29, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29390345/a-case-of-immunoglobulin-g4-related-lung-disease-with-bilateral-diffuse-infiltration-a-case-report
#15
Ailing Liu, Qianwen Zhang, Bo Liu, Ning Xu, Aijun Li
RATIONALE: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a rare and chronic progressive autoimmune disease. It is a novel clinical entity characterized by elevated serum IgG4 concentration and tissue infiltration by IgG4 plasma cells. IgG4-related lung disease (IgG4-RLD) has been described as interstitial pneumonia and inflammatory pseudotumor, with various abnormal radiographic patterns. We report a case of IgG4-related lung disease with bilateral diffuse infiltration. PATIENT CONCERNS: A 65-year-old woman was admitted to our hospital because of cough, sputum, and fever...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390339/infliximab-associated-with-life-threatening-lung-infection-in-a-patient-with-behcet-disease-with-intestinal-and-hematopoietic-system-involvement-a-case-report
#16
Yong Chen, Yan Shen, Hai-Fen Ma, Jian-Fei Cai, Yan-Qin Hua, Jun Zou, Jian-Long Guan
RATIONALE: Tumor necrosis factor (TNF-α) participates in the pathophysiology of Behcet's disease (BD) and myelodysplastic syndrome (MDS). Infliximab is recommaned for the most severe type of BD, however, there is little evidence for its effectiveness in BD associated MDS. PATIENT CONCERNS: A 46-year-old female, initially diagnosed with intestinal BD and leukopenia was later diagnosed as MDS. Treatement with infliximab and other immunoregulators lead to life-threatening pneumonia...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390256/sjogren-s-syndrome-complicating-pancytopenia-cerebral-hemorrhage-and-damage-in-nervous-system-a-case-report-and-literature-review
#17
Wenqing Yu, Wei Qu, Zhiyong Wang, Chunhong Xin, Rui Jing, Yinghui Shang, Huilin Zou, Hua Wang, Sizhou Feng
RATIONALE: Sjogren's syndrome(SS) is a chronic autoimmune disease, which damages exocrine glands especially salivary and lacrimal glands, with xerostomia and xerophthalmia as common symptoms. PATIENT CONCERNS: We report a case of a 49-year-old woman presented with pancytopenia. Her laboratory examinations lead us diagnose her as Sjogren's syndrome complicating pancytopenia. She had neurological symptoms during her treatment, which represent only 4.5% of Sjogren's syndrome complicating damage in nervous system...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383395/bacterial-sepsis-diagnostics-and-calculated-antibiotic-therapy
#18
REVIEW
D C Richter, A Heininger, T Brenner, M Hochreiter, M Bernhard, J Briegel, S Dubler, B Grabein, A Hecker, W A Kruger, K Mayer, M W Pletz, D Storzinger, N Pinder, T Hoppe-Tichy, S Weiterer, S Zimmermann, A Brinkmann, M A Weigand, C Lichtenstern
The mortality of patients with sepsis and septic shock is still unacceptably high. An effective calculated antibiotic treatment within 1 h of recognition of sepsis is an important target of sepsis treatment. Delays lead to an increase in mortality; therefore, structured treatment concepts form a rational foundation, taking relevant diagnostic and treatment steps into consideration. In addition to the assumed infection and individual risks of each patient, local resistance patterns and specific problem pathogens must be taken into account during the selection of anti-infective treatment...
January 30, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29382099/in-silico-and-in-vitro-guided-identification-of-inhibitors-of-alkylquinolone-dependent-quorum-sensing-in-pseudomonas-aeruginosa
#19
Fadi Soukarieh, Eduard Vico Oton, Jean-Frédéric Dubern, Janice Gomes, Nigel Halliday, Maria de Pilar Crespo, Jonathan Ramírez-Prada, Braulio Insuasty, Rodrigo Abonia, Jairo Quiroga, Stephan Heeb, Paul Williams, Michael J Stocks, Miguel Cámara
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis, wound and nosocomial infections, posing a serious burden to public health, due to its antibiotic resistance. The P. aeruginosa Pseudomonas Quinolone System (pqs) quorum sensing system, driven by the activation of the transcriptional regulator, PqsR (MvfR) by alkylquinolone (AQ) signal molecules, is a key player in the regulation of virulence and a potential target for the development of novel antibacterial agents. In this study, we performed in silico docking analysis, coupled with screening using a P...
January 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29382010/ct-and-pet-ct-findings-of-primary-pulmonary-diffuse-large-b-cell-lymphoma-one-case-report-and-literature-review
#20
REVIEW
Yanjun Bai, Wenjie Liang
RATIONALE: Primary pulmonary diffuse large B-cell lymphoma (PPL-DLBCL) is rare and its clinical manifestations lack specificity. In this report, we present one case of PPL-DLBCL with complete clinical and imaging data, including uncontrast-enhanced CT, contrast-enhanced CT, and positron emission tomography (PET)/CT. Previous cases will also be reviewed and summarized. PATIENT CONCERNS: A 62-year-old woman was hospitalized due to a swelling pain located in the right side of her back that persisted for >1 month...
November 2017: Medicine (Baltimore)
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