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Maternal fetal medicine

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https://www.readbyqxmd.com/read/29447720/no-257-ultrasonographic-cervical-length-assessment-in-predicting-preterm-birth-in-singleton-pregnancies
#1
Kenneth Lim, Kimberly Butt, Joan M Crane
OBJECTIVES: To review (1) the use of ultrasonographic-derived cervical length measurement in predicting preterm birth and (2) interventions associated with a short cervical length. OUTCOMES: Reduction in rates of prematurity and/or better identification of those at risk, as well as possible prevention of unnecessary interventions. EVIDENCE: Published literature was retrieved through searches of PubMed and The Cochrane Library up to December 2009, using appropriate controlled vocabulary and key words (preterm labour, ultrasound, cervix, incompetent cervix, transvaginal, transperineal, cervical length, fibronectin)...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29447091/obesity-in-pregnancy-a-comparison-of-four-national-guidelines
#2
Dana Vitner, Kristin Harris, Cynthia Maxwell, M D Farine
BACKGROUND: Obesity in pregnancy has become one of the most important challenges in obstetrical care given its prevalence and potential adverse impact on both mother and fetus. The primary objective of this descriptive review is to identify common themes and distinctions within the current recommendations for maternal obesity in the most updated version of four published national guidelines. METHODS: We reviewed the following guidelines for obesity in pregnancy: American College of Obstetricians and Gynecologists (ACOG) 2015, Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG) 2013, Royal College of Obstetrics and Gynecology (RCOG) 2010, and Society of Obstetrics and Gynecologists of Canada (SOGC) 2010...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29433145/effect-of-cord-blood-magnesium-level-at-birth-on-non-neurologic-neonatal-outcomes
#3
James M Edwards, Laura E Edwards, Geeta K Swamy, Chad A Grotegut
OBJECTIVE: We examined the effects of magnesium sulfate on non-neurologic neonatal outcomes with respect to cord blood magnesium level. STUDY DESIGN: We conducted a secondary analysis of the Maternal-Fetal Medicine Units Beneficial Effects of Antenatal Magnesium (MFMU BEAM) trial comparing the upper and lower quintiles of cord blood magnesium level. Outcomes included cerebral palsy (CP), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and assessments of mental and motor disability...
February 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29425726/does-poor-fetal-growth-influence-the-extent-of-fetal-exposure-to-maternal-medications
#4
REVIEW
Jia Yin Soo, Michael D Wiese, Mary J Berry, Janna L Morrison
A large proportion of women are prescribed a medication during pregnancy, and the conditions requiring treatment with these medicines are often also associated with placental dysfunction and abnormal fetal growth. For the fetus, exposure to maternal illness or medications can alter fetal growth trajectory, which is a key indicator of fetal and postnatal wellbeing. There is a large amount of human and animal evidence highlighting the hormonal and/or metabolic changes that occur in both the mother and the fetus as a result of maternal illness or either excessive or restricted fetal growth...
February 6, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29420394/second-stage-duration-and-outcomes-among-women-who-labored-after-a-prior-cesarean-delivery
#5
Mark P Hehir, Dwight J Rouse, Russell S Miller, Cande V Ananth, Jason D Wright, Zainab Siddiq, Mary E DʼAlton, Alexander M Friedman
OBJECTIVE: To characterize probabilities of vaginal delivery based on second-stage duration along with maternal and neonatal risks for women undergoing labor after cesarean delivery. METHODS: This unplanned secondary analysis of the Maternal-Fetal Medicine Units Cesarean Registry, a prospective observational cohort, assessed outcomes in women with a prior uterine scar and included women with a previous cesarean delivery without prior vaginal delivery who reached the second stage of labor...
February 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29419329/understanding-gastroschisis-and-its-clinical-management-where-are-we
#6
Candace Haddock, Erik D Skarsgard
Gastroschisis is the commonest developmental defect of the anterior abdominal wall in both developed and developing countries. The past 30 years have seen transformational improvements in outcome due to advances in neonatal intensive care and enhanced integration between the disciplines of maternal fetal medicine, neonatology and pediatric surgery. A review of gastroschisis, which emphasizes its epidemiology, multidisciplinary care strategies and contemporary outcomes is timely. Areas covered: This review discusses the current state of knowledge related to prevalence and causation, and postulated embryopathologic mechanisms contributing to the development of gastroschisis...
February 8, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29409368/reference-centiles-for-the-middle-cerebral-artery-and-umbilical-artery-pulsatility-index-and-cerebro-placental-ratio-from-a-low-risk-population-a-generalised-additive-model-for-location-shape-and-scale-gamlss-approach
#7
Christopher Flatley, Sailesh Kumar, Ristan M Greer
OBJECTIVE: The primary aim of this study was to create reference ranges for the fetal Middle Cerebral artery Pulsatility Index (MCA PI), Umbilical Artery Pulsatility Index (UA PI) and the Cerebro-Placental Ratio (CPR) in a clearly defined low-risk cohort using the Generalised Additive Model for Location, Shape and Scale (GAMLSS) method. METHODS: Prospectively collected cross-sectional biometry and Doppler data from low-risk women attending the Mater Mother's Hospital, Maternal and Fetal Medicine Department in Brisbane, Australia between January 2010 and April 2017 were used to derive gestation specific centiles for the MCA PI, UA PI and CPR...
February 6, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29407514/prenatal-stress-and-genetic-risk-how-prenatal-stress-interacts-with-genetics-to-alter-risk-for-psychiatric-illness
#8
REVIEW
Parker W Abbott, Serena B Gumusoglu, Jada Bittle, David Q Beversdorf, Hanna E Stevens
Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic endowment and their environmental experiences and exposures. Embryonic development captures a particularly complex period, in which genetic and environmental factors can interact to contribute to risk. These environmental factors are incorporated differently into the embryonic brain than postnatal one. Here, we comprehensively review the human and animal model literature for studies that assess the interaction between genetic risks and one particular environmental exposure with strong and complex associations with neuropsychiatric outcomes-prenatal maternal stress...
January 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29403316/validation-of-modified-world-health-organization-classification-for-pregnant-women-with-heart-disease-in-a-tertiary-care-center-in-southern-thailand
#9
Chitkasaem Suwanrath, Putthaporn Thongphanang, Sutham Pinjaroen, Saranyou Suwanugsorn
Purpose: To validate the modified World Health Organization (WHO) classification in pregnant women with congenital and acquired heart diseases. Patients and methods: The database of pregnant women with heart disease, who delivered at Songklanagarind Hospital between January 1995 and December 2016, was retrieved from the Statistical Unit, Department of Obstetrics and Gynecology, along with the Hospital Information System of Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29399860/reproducibility-of-lung-to-head-ratio-ultrasound-measurements-in-congenital-diaphragmatic-hernia
#10
Victoria Arruga Novoa Y Novoa, Laura F Sutton, Allan E Neis, Amber M Marroquin, Tamara A Freimund, Tracey M Coleman, Kathleen A Praska, Krystal L Ruka, Vicki L Warzala, Haleh Sangi-Haghpeykar, Rodrigo Ruano
OBJECTIVES: This study investigated the reproducibility of standardization of lung-to-head ratio measurements in congenital diaphragmatic hernia (CDH) at our center among sonographers after we standardized the method. METHODS: We reviewed ultrasound images of 12 fetuses with CDH at Mayo Clinic from 2010 to 2016. Nine operators (1 maternal-fetal medicine specialist with experience in measuring the lung-to-head ratio and 8 sonographers), who were blinded to previous findings, reviewed 33 selected images from 12 fetuses with left CDH...
February 5, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29397381/investigation-of-the-prevalence-and-causes-and-of-legal-abortion-of-teenage-married-mothers-in-iran
#11
Fatemeh Ghodrati, Narges Saadatmand, Saeid Gholamzadeh, Marzieh Akbarzadeh
Background The therapeutic abortion law, in accordance with the fatwa issued by our Muslim jurisprudent approved by the parliament in 2005, has made major developments in dealing with cases of therapeutic abortions. Objective This study aimed at identifying the prevalence and causes of therapeutic abortion requests to the Legal Medicine Organization of Fars province, Shiraz, by pregnant teenager mothers. Methods This study was a retrospective, cross-sectional, descriptive survey. In this study, all documents related to therapeutic abortion requests from the Legal Medicine Organization of Fars province (southern Iran) from 2006 to 2013 were investigated...
February 5, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29381473/low-dose-aspirin-for-preventing-fetal-growth-restriction-a-randomised-trial
#12
Anca-Daniela Stanescu, Roxana Banica, Romina-Marina Sima, Liana Ples
The purpose of this study was to investigate when in pregnancy to stop the administration of low dose aspirin (150 mg/daily) so as to prevent fetal growth restriction (FGR) A randomised, placebo-controlled study was designed. The patients were all screened positive using the Fetal Medicine Foundation (FMF) early pregnancy screening test for preeclampsia (PE) and FGR prediction. One hundred and fifty patients were enrolled and divided equally into three groups: A - the controls who received placebo treatment; B - those who received aspirin till 32 weeks of gestation and C - those who received aspirin till 36 weeks of gestation...
January 30, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29380918/aspre-trial-incidence-of-preterm-preeclampsia-in-patients-fulfilling-acog-and-nice-criteria-according-to-risk-by-the-fmf-algorithm
#13
Liona C Poon, Daniel L Rolnik, Min Yi Tan, Juan Luis Delgado, Theodora Tsokaki, Ranjit Akolekar, Mandeep Singh, Walkyria Andrade, Tunay Efeturk, Jacques C Jani, Walter Plasencia, George Papaioannou, Ana Rosa Blazquez, Ilma Floriana Carbone, David Wright, Kypros H Nicolaides
OBJECTIVE: To report the incidence of preterm preeclampsia (PE) in women that fulfil the screening criteria of the National Institute for Health and Clinical Excellence (NICE) and American Congress of Obstetricians and Gynecologists (ACOG) and compare the incidence in those that are screen positive and screen negative by the Fetal Medicine Foundation (FMF) algorithm. STUDY DESIGN: This was a secondary analysis of data from the ASPRE study. The study population consisted of women with singleton pregnancies who had prospective screening for preterm-PE by means of the FMF algorithm that combines maternal factors and biomarkers at 11-13 weeks' gestation...
January 30, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29368789/techniques-for-repair-of-obstetric-anal-sphincter-injuries
#14
Melanie R Meister, Joshua I Rosenbloom, Jerry L Lowder, Alison G Cahill
Importance: Obstetric anal sphincter injuries (OASISs) complicate up to 11% of vaginal deliveries; obstetricians must be able to recognize and manage these technically challenging injuries. Objective: The aim of this study was to share our approach for management of these challenging complications of childbirth based on a multidisciplinary collaboration between general obstetrician-gynecologists, maternal fetal medicine specialists, and female pelvic medicine and reconstructive surgeons established at our institution...
January 2018: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29365328/outcomes-of-spontaneous-labor-in-women-undergoing-trial-of-labor-after-cesarean-as-compared-with-nulliparous-women-a-retrospective-cohort-study
#15
Sarah C Lassey, Julian N Robinson, Anjali J Kaimal, Sarah E Little
OBJECTIVE: The objective of this study was to compare spontaneous labor outcomes in women undergoing trial of labor after cesarean (TOLAC) and nulliparas to better counsel women. STUDY DESIGN: A 4-year retrospective cohort. We included women at term in spontaneous labor with vertex singletons and no more than one prior cesarean delivery. In planned secondary analysis, we focused on a subset of women with a prior cesarean and a predicted likelihood of a successful vaginal delivery of 70% or more based on the Maternal-Fetal Medicine Units-vaginal birth after cesarean (VBAC) calculator...
January 24, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29361931/obstetrical-provider-knowledge-and-attitudes-towards-cell-free-dna-screening-results-of-a-cross-sectional-national-survey
#16
Wilson V Chan, Jo-Ann Johnson, R Douglas Wilson, Amy Metcalfe
BACKGROUND: Cell-free DNA (cfDNA) screening has recently acquired tremendous attention, promising patients and healthcare providers a more accurate prenatal screen for aneuploidy than other current screening modalities. It is unclear how much knowledge regarding cfDNA screening obstetrical providers possess which has important implications for the quality and content of the informed consent patients receive. METHODS: A survey was designed to assess obstetrical provider knowledge and attitudes towards cfDNA screening and distributed online through the Society of Obstetricians & Gynecologists of Canada (SOGC)...
January 23, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29356333/limitations-of-vaginal-birth-after-cesarean-success-prediction
#17
Patrick Thornton
The Society for Maternal-Fetal Medicine endorses an algorithm for estimating the probability of successful vaginal birth for women undergoing trial of labor after cesarean (TOLAC). The algorithm is available online in the form of an easy-to-use calculator. This calculator has significant limitations that are easily overlooked by women and providers alike. The calculator has much greater positive than negative predictive power, and it cannot predict unsuccessful TOLAC or uterine rupture. Furthermore, the calculator cannot predict rare catastrophes, such as unplanned hysterectomy, permanent injury, or death...
January 22, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29356242/preferable-in-vitro-condition-for-maintaining-faithful-dna-methylation-imprinting-in-mouse-embryonic-stem-cells
#18
Jiyoung Lee, Ayumi Matsuzawa, Hirosuke Shiura, Akito Sutani, Fumitoshi Ishino
Epigenetic properties of cultured embryonic stem cells (ESCs), including DNA methylation imprinting, are important because they affect the developmental potential. Here, we tested a variety of culture media, including knockout serum replacement (KSR) and fetal bovine serum (FBS) with or without inhibitors of Gsk3β and Mek1/2 (2i) at various time points. In addition to the previously known passage-dependent global changes, unexpected dynamic DNA methylation changes occurred in both maternal and paternal differentially methylated regions: under the widely used condition of KSR with 2i, a highly hypomethylated state occurred at early passages (P1-7) as well as P10, but DNA methylation increased over further passages in most conditions, except under KSR with 2i at P25...
January 22, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29350490/chronic-exposure-to-high-doses-of-selenium-in-the-first-trimester-of-pregnancy-case-report-and-brief-literature-review
#19
Luisa D'Oria, Massimo Apicella, Carmen De Luca, Angelo Licameli, Caterina Neri, Marcella Pellegrino, Daniela Simeone, Marco De Santis
BACKGROUND: Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE: A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestational week (g.w.) 7 to 12, due to a prescription error. The patient experienced nausea, vomiting, hand and foot paresthesia, followed by fatigue, loss of fingernails and hair...
January 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29349587/the-danish-medical-birth-register
#20
REVIEW
Mette Bliddal, Anne Broe, Anton Pottegård, Jørn Olsen, Jens Langhoff-Roos
The Danish Medical Birth Register was established in 1973. It is a key component of the Danish health information system. The register enables monitoring of the health of pregnant women and their offspring, it provides data for quality assessment of the perinatal care in Denmark, and it is used extensively for research. The register underwent major changes in construction and content in 1997, and new variables have been added during the last 20 years. The aim was to provide an updated description of the register focusing on structure, content, and coverage since 1997...
January 19, 2018: European Journal of Epidemiology
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