keyword
https://read.qxmd.com/read/38524734/the-montana-interfacility-blood-network-a-novel-lifesaving-hand-off-for-the-optimal-care-of-rural-patients
#1
JOURNAL ARTICLE
Gordon M Riha, Alyssa Johnson, Sadie Arnold, Michael S Englehart, Simon J Thompson
PURPOSE: The state of Montana encompasses and defines rural health care as it is known in the United States (US) today. This vast area is punctuated by pockets of health care availability with varying access to blood products for transfusion. Furthermore, timely transport is frequently challenged by weather that may limit air transportation options, resulting in multiple hours in ground transport to definitive care. PATIENTS AND METHODS: The Montana State Trauma Care Committee (MT-STCC) developed the Montana Interfacility Blood Network (MT-IBN) to ensure blood availability in geographically distanced cases where patients may otherwise not survive...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38485355/habits-attitudes-and-expectations-of-regular-users-of-partial-driving-automation-systems
#2
JOURNAL ARTICLE
Alexandra S Mueller, Jessica B Cicchino, Joseph V Calvanelli
INTRODUCTION: Little is known about regular users' perceptions of partial (Level 2) automation or how those perceptions affect behind-the-wheel behavior. METHOD: A mixed mode (phone and online) survey explored the habits, expectations, and attitudes among regular users of General Motors Super Cruise (n = 200), Nissan/Infiniti ProPILOT Assist (n = 202), and Tesla Autopilot (n = 202). RESULTS: All three groups reported being more likely to engage in non-driving-related activities while using their systems than while driving unassisted...
February 2024: Journal of Safety Research
https://read.qxmd.com/read/38478018/snare-chaperone-sly1-directly-mediates-close-range-vesicle-tethering
#3
JOURNAL ARTICLE
Mengtong Duan, Rachael L Plemel, Tomoka Takenaka, Ariel Lin, Beatriz Marie Delgado, Una Nattermann, Daniel P Nickerson, Joji Mima, Elizabeth A Miller, Alexey J Merz
The essential Golgi protein Sly1 is a member of the Sec1/mammalian Unc-18 (SM) family of SNARE chaperones. Sly1 was originally identified through remarkable gain-of-function alleles that bypass requirements for diverse vesicle tethering factors. Employing genetic analyses and chemically defined reconstitutions of ER-Golgi fusion, we discovered that a loop conserved among Sly1 family members is not only autoinhibitory but also acts as a positive effector. An amphipathic lipid packing sensor (ALPS)-like helix within the loop directly binds high-curvature membranes...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38462247/prescriptive-and-proscriptive-lessons-for-managing-shoulder-dystocia-a-technical-and-videographical-tutorial
#4
REVIEW
Edith Gurewitsch Allen
This tutorial of the intrapartum management of shoulder dystocia uses drawings and videos of simulated and actual deliveries to illustrate the biomechanical principles of specialized delivery maneuvers and examine missteps associated with brachial plexus injury. It is intended to complement haptic, mannequin-based simulation training. Demonstrative explication of each maneuver is accompanied by specific examples of what not to do. Positive (prescriptive) instruction prioritizes early use of direct fetal manipulation and stresses the importance of determining the alignment of the fetal shoulders by direct palpation, and that the biacromial width should be manually adjusted to an oblique orientation within the pelvis-before application of traction to the fetal head, the biacromial width is manually adjusted to an oblique orientation within the pelvis...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38447140/deep-learning-assisted-sensor-with-multiple-perception-capabilities-for-an-intelligent-driver-assistance-monitoring-system
#5
JOURNAL ARTICLE
Jingliang Lv, Yu Wang, Haiyue Fu, Yulong Pei, Zhijie Xie
Driver assistance systems can help drivers achieve better control of their vehicles while driving and reduce driver fatigue and errors. However, the current driver assistance devices have a complex structure and severely violate the privacy of drivers, hindering the development of driver assistance technology. To address these limitations, this article proposes an intelligent driver assistance monitoring system (IDAMS), which combines a Kresling origami structure-based triboelectric sensor (KOS-TS) and a convolutional neural network (CNN)-based data analysis...
March 6, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38444623/automated-test-apparatus-for-bench-testing-the-magnetic-field-homogeneity-of-nmr-transceiver-coils
#6
JOURNAL ARTICLE
Jose L Uribe, Matthew D Jimenez, Jessica I Kelz, Jeanie Liang, Rachel W Martin
We describe an automated hands-off bench testing method for measuring the magnetic field profile of transceiver coils for nuclear magnetic resonance (NMR). The scattering parameter (S-parameter) data is measured using a portable network analyzer, and the results are automatically exported to a computer for plotting and viewing. This assay dramatically reduces the time needed to measure the magnetic field (B1 ) homogeneity profile of a transceiver coil while also improving accuracy relative to manual operation...
March 2024: Journal of Magnetic Resonance Open
https://read.qxmd.com/read/38398960/automated-nanodroplet-dispensing-for-large-scale-spheroid-generation-via-hanging-drop-and-parallelized-lossless-spheroid-harvesting
#7
JOURNAL ARTICLE
Viktoria Zieger, Ellen Woehr, Stefan Zimmermann, Daniel Frejek, Peter Koltay, Roland Zengerle, Sabrina Kartmann
Creating model systems that replicate in vivo tissues is crucial for understanding complex biological pathways like drug response and disease progression. Three-dimensional (3D) in vitro models, especially multicellular spheroids (MCSs), offer valuable insights into physiological processes. However, generating MCSs at scale with consistent properties and efficiently recovering them pose challenges. We introduce a workflow that automates large-scale spheroid production and enables parallel harvesting into individual wells of a microtiter plate...
January 31, 2024: Micromachines
https://read.qxmd.com/read/38358840/advances-in-managing-chytridiomycosis-for-australian-frogs-gradarius-firmus-victoria
#8
REVIEW
Lee Berger, Lee F Skerratt, Tiffany A Kosch, Laura A Brannelly, Rebecca J Webb, Anthony W Waddle
Extensive knowledge gains from research worldwide over the 25 years since the discovery of chytridiomycosis can be used for improved management. Strategies that have saved populations in the short term and/or enabled recovery include captive breeding, translocation into disease refugia, translocation from resistant populations, disease-free exclosures, and preservation of disease refuges with connectivity to previous habitat, while antifungal treatments have reduced mortality rates in the wild. Increasing host resistance is the goal of many strategies under development, including vaccination and targeted genetic interventions...
February 15, 2024: Annual Review of Animal Biosciences
https://read.qxmd.com/read/38297615/compact-ultrastable-high-repetition-rate-2-%C3%AE-m-and-3-%C3%AE-m-fiber-laser-for-seeding-mid-ir-opcpa
#9
JOURNAL ARTICLE
W Hettel, G Golba, D Morrill, D Carlson, P Chang, T-H Wu, S Diddams, H Kapteyn, M Murnane, M Hemmer
We report a compact and reliable ultrafast fiber laser system optimized for seeding a high energy, 2 μm pumped, 3 μm wavelength optical parametric chirped pulse amplification to drive soft X-ray high harmonics. The system delivers 100 MHz narrowband 2 μm pulses with >1 nJ energy, synchronized with ultra-broadband optical pulses with a ∼1 μm FWHM spectrum centered at 3 μm with 39 pJ pulse energy. The 2 μm and 3 μm pulses are derived from a single 1.5 μm fiber oscillator, fully fiber integrated with free-space downconversion for the 3 μm...
January 29, 2024: Optics Express
https://read.qxmd.com/read/38214596/eliminating-hands-off-handoffs-improvement-in-perioperative-handoff-communication-with-a-multidisciplinary-tool-initiative
#10
JOURNAL ARTICLE
David P Ebertz, Emily Steinhagen, Christine E Alvarado, Katherine Bingmer, Daniel Asher, Amy Berardinelli, John Ammori
INTRODUCTION: Handoffs between the operating room (OR) and post-anesthesia care unit (PACU) require a high volume and quality of information to be transferred. This study aimed to improve perioperative communication with a handoff tool. METHODS: Perioperative staff at a quaternary care center was surveyed regarding perception of handoff quality, and OR to PACU handoffs were observed for structured criteria. A 25-item tool was implemented, and handoffs were similarly observed...
January 12, 2024: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://read.qxmd.com/read/38171214/target-lysis-by-cholesterol-extraction-is-a-rate-limiting-step-in-the-resolution-of-phagolysosomes
#11
JOURNAL ARTICLE
Dante Barreda, Sergio Grinstein, Spencer A Freeman
The ongoing phagocytic activity of macrophages necessitates an extraordinary capacity to digest and resolve incoming material. While the initial steps leading to the formation of a terminal phagolysosome are well studied, much less is known about the later stages of this process, namely the degradation and resolution of the phagolysosomal contents. We report that the degradation of targets such as splenocytes and erythrocytes by phagolysosomes occurs in a stepwise fashion, requiring lysis of their plasmalemmal bilayer as an essential initial step...
December 27, 2023: European Journal of Cell Biology
https://read.qxmd.com/read/38165188/simulation-based-comparison-of-british-and-australian-advanced-life-support-guidelines
#12
JOURNAL ARTICLE
Fawaz Altuwaijri
INTRODUCTION: Cardiac arrest is a major health concern that has been linked to poor disease outcomes. Cardiopulmonary resuscitation (CPR) is a critical protocol for restoring spontaneous circulation. The guidelines used by medical staff differ across different countries. A comparison of these guidelines can help in designing more efficient Advanced Life Support (ALS) protocols. The goal in this study was to compare the guidelines for interruption of compression during CPR (hands-off time) for ALS protocols provided by Australian and United Kingdom (UK) resuscitation councils...
November 2023: Western Journal of Emergency Medicine
https://read.qxmd.com/read/38160732/exploring-unequal-class-logics-of-mealtime-food-socialisation-an-ethnography-of-family-meals-in-france-and-australia
#13
JOURNAL ARTICLE
Fairley Le Moal, Maxime Michaud, John Coveney
Regular family mealtimes are occasions to model food consumption and have been associated with health and well-being benefits for children. This study aimed to investigate children's mealtime food socialisation in socially diverse households. Nine families from France and five from Australia were recruited, ranging from lower middle-class to upper-class positions, with children mostly between the ages of five to eight. The data is composed of the observations of 47 mealtimes and semi-directive interviews with both parents...
December 29, 2023: Appetite
https://read.qxmd.com/read/38141571/the-reactivation-of-task-rules-triggers-the-reactivation-of-task-relevant-items
#14
JOURNAL ARTICLE
Yağmur D Şentürk, Nursima Ünver, Can Demircan, Tobias Egner, Eren Günseli
Working memory (WM) describes the temporary storage of task-relevant items and procedural rules to guide action. Despite its central importance for goal-directed behavior, the interplay between WM and long-term memory (LTM) remains poorly understood. Recent studies have shown that repeated use of the same task-relevant item in WM results in a hand-off of the storage of that item to LTM, and switching to a new item reactivates WM. To further elucidate the rules governing WM-LTM interactions, we here planned to probe whether a change in task rules, independent of a switch in task-relevant items, would also lead to WM reactivation of maintained items...
November 23, 2023: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://read.qxmd.com/read/38131105/residues-within-the-lptc-transmembrane-helix-are-critical-for-escherichia-coli-lptb-2-fg-atpase-regulation
#15
JOURNAL ARTICLE
Nicholas P Cina, Dara W Frank, Candice S Klug
Lipopolysaccharide (LPS) synthesis in Gram-negative bacteria is completed at the outer leaflet of the inner membrane (IM). Following synthesis, seven LPS transport (Lpt) proteins facilitate the movement of LPS to the outer membrane (OM), an essential process that, if disrupted at any stage, has lethal effects on bacterial viability. LptB2 FG, the IM component of the Lpt bridge system, is a type VI ABC transporter that provides the driving force for LPS extraction from the IM and subsequent transport across a stable protein bridge to the outer leaflet of the OM...
December 22, 2023: Protein Science
https://read.qxmd.com/read/38127817/the-duckweed-dip-aquatic-spirodela-polyrhiza-plants-can-efficiently-uptake-dissolved-dna-wrapped-carbon-nanotubes-from-their-environment-for-transient-gene-expression
#16
JOURNAL ARTICLE
Tasmia Islam, Swapna Kalkar, Rachel Tinker-Kulberg, Tetyana Ignatova, Eric A Josephs
Duckweeds ( Lemnaceae ) are aquatic nongrass monocots that are the smallest and fastest-growing flowering plants in the world. While having simplified morphologies, relatively small genomes, and many other ideal traits for emerging applications in plant biotechnology, duckweeds have been largely overlooked in this era of synthetic biology. Here, we report that Greater Duckweed ( Spirodela polyrhiza ), when simply incubated in a solution containing plasmid-wrapped carbon nanotubes (DNA-CNTs), can directly uptake the DNA-CNTs from their growth media with high efficiency and that transgenes encoded within the plasmids are expressed by the plants─without the usual need for large doses of nanomaterials or agrobacterium to be directly infiltrated into plant tissue...
December 21, 2023: ACS Synthetic Biology
https://read.qxmd.com/read/38110144/live-stream-of-prehospital-point-of-care-ultrasound-during-cardiopulmonary-resuscitation-a-feasibility-trial
#17
JOURNAL ARTICLE
C Hafner, V Manschein, D A Klaus, W Schaubmayr, A Tiboldi, V Scharner, A Gleiss, B Thal, M Krammel, T Hamp, H Willschke, M Hermann
BACKGROUND: Current resuscitation guidelines recommend that skilled persons could use ultrasound to detect reversible causes during cardiopulmonary resuscitation (CPR) where the examination can be safely integrated into the Advanced Life Support (ALS) algorithm. However, in a prehospital setting performing and rapidly interpreting ultrasound can be challenging for physicians. Implementing remote, expert-guided, and real-time transmissions of ultrasound examinations offers the opportunity for tele-support, even during an out-of-hospital cardiac arrest (OHCA)...
December 16, 2023: Resuscitation
https://read.qxmd.com/read/37996323/comparing-the-effects-of-blended-learning-and-traditional-instruction-on-basic-life-support-for-laypersons-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
Ying-Chih Ko, Hao-Yang Lin, Wen-Chu Chiang, Chih-Wei Yang, Ming-Ju Hsieh, Matthew Huei-Ming Ma
BACKGROUND/PURPOSE: Blended learning offers the advantages of both instructor-led and self-instruction methods in basic life support (BLS). Our study aims to compare the effects of blended learning with those of traditional instructor-led methods on the performance of laypersons taking BLS courses. METHODS: A total of 108 participants were randomly assigned to three groups: traditional instruction (group A, n = 36), blended learning with two rounds of practice (group B, n = 36), and blended learning with three rounds of practice (group C, n = 36)...
November 22, 2023: Journal of the Formosan Medical Association
https://read.qxmd.com/read/37973909/feasibility-of-resuscitative-transesophageal-echocardiography-at-out-of-hospital-emergency-scenes-of-cardiac-arrest
#19
JOURNAL ARTICLE
Mario Krammel, Thomas Hamp, Christina Hafner, Ingrid Magnet, Michael Poppe, Peter Marhofer
Guidelines recommend the use of ultrasound in cardiac arrest. Transthoracic echocardiography, has issues with image quality and by increasing hands-off times during resuscitation. We assessed the feasibility of transesophageal echocardiography (TEE), which does not have both problems, at out-of-hospital cardiac arrest (OHCA) emergency scenes. Included were 10 adults with non-traumatic OHCA in Vienna, Austria. An expert in emergency ultrasound was dispatched to the scenes in addition to the resuscitation team...
November 16, 2023: Scientific Reports
https://read.qxmd.com/read/37949227/structure-of-phosphorylated-like-rssb-the-adaptor-delivering-%C3%AF-s-to-the-clpxp-proteolytic-machinery-reveals-an-interface-switch-for-activation
#20
JOURNAL ARTICLE
Christiane Brugger, Jacob Schwartz, Scott Novick, Song Tong, Joel Hoskins, Nadim Majdalani, Rebecca Kim, Martin Filipovski, Sue Wickner, Susan Gottesman, Patrick Griffin, Alexandra M Deaconescu
In enterobacteria such as Escherichia coli, the general stress response is mediated by σs , the stationary phase dissociable promoter specificity subunit of RNA polymerase. σs is degraded by ClpXP during active growth in a process dependent on the RssB adaptor, which is thought to be stimulated by phosphorylation of a conserved aspartate in its N-terminal receiver domain. Here we present the crystal structure of full-length RssB bound to a beryllofluoride phosphomimic. Compared to the structure of RssB bound to the IraD anti-adaptor, our new RssB structure with bound beryllofluoride reveals conformational differences and coil-to-helix transitions in the C-terminal region of the RssB receiver domain and in the inter-domain segmented helical linker...
November 8, 2023: Journal of Biological Chemistry
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