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https://www.readbyqxmd.com/read/27916652/exploring-pericyte-and-cardiac-stem-cell-secretome-unveils-new-tactics-for-drug-discovery
#1
REVIEW
Georgina M Ellison-Hughes, Paolo Madeddu
Ischaemic diseases remain a major cause of morbidity and mortality despite continuous advancements in medical and interventional treatments. Moreover, available drugs reduce symptoms associated with tissue ischaemia, without providing a definitive repair. Cardiovascular regenerative medicine is an expanding field of research that aims to improve the treatment of ischaemic disorders through restorative methods, such as gene therapy, stem cell therapy, and tissue engineering. Stem cell transplantation has salutary effects through direct and indirect actions, the latter being attributable to growth factors and cytokines released by stem cells and influencing the endogenous mechanisms of repair...
December 1, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27894249/brief-compression-only-cardiopulmonary-resuscitation-training-video-and-simulation-with-homemade-mannequin-improves-cpr-skills
#2
Gregory K Wanner, Arayel Osborne, Charlotte H Greene
BACKGROUND: Cardiopulmonary resuscitation (CPR) training has traditionally involved classroom-based courses or, more recently, home-based video self-instruction. These methods typically require preparation and purchase fee; which can dissuade many potential bystanders from receiving training. This study aimed to evaluate the effectiveness of teaching compression-only CPR to previously untrained individuals using our 6-min online CPR training video and skills practice on a homemade mannequin, reproduced by viewers with commonly available items (towel, toilet paper roll, t-shirt)...
November 29, 2016: BMC Emergency Medicine
https://www.readbyqxmd.com/read/27887756/needlestick-injuries-among-healthcare-professionals-in-training-using-the-surgical-time-out-and-hand-off-protocols-to-deter-high-risk-needlesticks
#3
EDITORIAL
G A Katsevman, J A Braca, C L Sedney, L Hatchett
No abstract text is available yet for this article.
November 3, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27850010/370-descriptive-analysis-of-hands-off-activity-in-cpr-events-using-real-time-video-data
#4
Mahsheed Taeb, Jamie Schwartz, Michael Spaeder, Amanda Levin
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27842502/the-experiences-of-family-members-in-the-nursing-home-to-hospital-transfer-decision
#5
Kathleen Abrahamson, Brittany Bernard, Lara Magnabosco, Arif Nazir, Kathleen T Unroe
BACKGROUND: The objective of this study was to better understand the experiences of family members in the nursing home to hospital transfer decision making process. Semi-structured interviews were conducted with 20 family members who had recently been involved in a nursing home to hospital transfer decision. RESULTS: Family members perceived themselves to play an advocacy role in their resident's care and interview themes clustered within three over-arching categories: Family perception of the nursing home's capacity to provide medical care: Resident and family choices; and issues at 'hand-off' and the hospital...
November 15, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27832586/the-human-microbiome-before-birth
#6
Martin J Blaser, Maria G Dominguez-Bello
The conservation of the microbiota within humans and other hominids suggests an ancient assembly that has been selected to optimize host fitness. Pregnancy induces changes in the maternal microbiome just before the intergenerational hand-off of the microbiota. Interventions, including peri-partum antibiotics and Cesarean sections, may have unintended effects on babies.
November 9, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27803024/directly-comparing-handoff-protocols-for-pediatric-hospitalists
#7
Elizabeth H Lazzara, Robert Riss, Brady Patzer, Dustin C Smith, Y Raymond Chan, Joseph R Keebler, Sarah D Fouquet, Evan M Palmer
BACKGROUND AND OBJECTIVES: Handoff protocols are often developed by brainstorming and consensus, and few are directly compared. We hypothesized that a handoff protocol (Flex 11) developed using a rigorous methodology would be more favorable in terms of clinicians' attitudes, behaviors, cognitions, or time-on-task when performing handoffs compared with a prevalent protocol (Situation Background Assessment Recommendation [SBAR]). METHODS: Using a between-groups, randomized control trial design (Flex 11 versus SBAR) during a pilot study in a simulated environment, 20 clinicians (13 attending physicians and 7 residents) received 3 patient handoffs from a standardized physician, managed the patients, and handed off the patients to the same standardized physician...
December 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27780740/comparative-performance-assessment-of-commercially-available-automatic-external-defibrillators-a-simulation-and-real-life-measurement-study-of-hands-off-time
#8
Simone Savastano, Vincenzo Vanni, Roman Burkart, Maurizio Raimondi, Fabrizio Canevari, Simone Molinari, Enrico Baldi, Aurora I Danza, Maria Luce Caputo, Romano Mauri, Francois Regoli, Giulio Conte, Claudio Benvenuti, Angelo Auricchio
PURPOSE: Early and good quality cardiopulmonary resuscitation (CPR) and the use of automated external defibrillators (AEDs) improve cardiac arrest patients' survival. However, AED peri- and post-shock/analysis pauses may reduce CPR effectiveness. METHODS: The time performance of 12 different commercially available AEDs was tested in a manikin based scenario; then the AEDs recordings from the same tested models following the clinical use both in Pavia and Ticino were analyzed to evaluate the post-shock and post-analysis time...
October 22, 2016: Resuscitation
https://www.readbyqxmd.com/read/27756513/cardiopulmonary-resuscitation-using-the-lifeline-arm-mechanical-chest-compression-device-a-randomized-crossover-manikin-trial
#9
Lukasz Szarpak, Zenon Truszewski, Lukasz Czyzewski, Michael Frass, Oliver Robak
INTRODUCTION: European Resuscitation Council as well as American Heart Association guidelines for cardiopulmonary resuscitation (CPR) stress the importance of uninterrupted and effective chest compressions (CCs). Manual CPR decreases in quality of CCs over time because of fatigue which impacts outcome. We report the first study with the Lifeline ARM automated CC device for providing uninterrupted CCs. METHODS: Seventy-eight paramedics participated in this randomized, crossover, manikin trial...
October 7, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27700977/a-simple-evidence-based-intervention-to-improve-care-transitions-for-frail-patients-with-complex-health-conditions-why%C3%A2-didn-t-it-work-as-expected
#10
David McNeil, Roger Strasser, Nancy Lightfoot, Raymond Pong
The transition from hospital to home is a vulnerable period for patients with complex conditions, who are often frail, at risk for adverse events and unable to navigate a system of poorly coordinated care in the post-discharge period. Care transition interventions are seen as effective care coordinating mechanisms for reducing avoidable adverse events associated with the transition of the patient from the hospital to the home. A study was undertaken to evaluate the effectiveness of a care transition intervention involving a hand-off between a hospital-based care transitions nurse and a community-based rapid response nurse...
2016: Healthcare Quarterly
https://www.readbyqxmd.com/read/27668920/two-thumb-encircling-technique-over-the-head-of-patients-in-the-setting-of-lone-rescuer-infant-cpr-occurred-during-ambulance-transfer-a-crossover-simulation-study
#11
Choong Hyun Jo, Gyu Chong Cho, Chang Hee Lee
OBJECTIVE: The purpose of this study was to determine if the over-the-head 2-thumb encircling technique (OTTT) provides better overall quality of cardiopulmonary resuscitation compared with conventional 2-finger technique (TFT) for a lone rescuer in the setting of infant cardiac arrest in ambulance. METHODS: Fifty medical emergency service students were voluntarily recruited to perform lone rescuer infant cardiopulmonary resuscitation for 2 minutes on a manikin simulating a 3-month-old baby in an ambulance...
September 23, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27658651/a-novel-protocol-for-dispatcher-assisted-cpr-improves-cpr-quality-and-motivation-among-rescuers-a-randomized-controlled-simulation-study
#12
Stinne Eika Rasmussen, Mette Amalie Nebsbjerg, Lise Qvirin Krogh, Katrine Bjørnshave, Kristian Krogh, Jonas Agerlund Povlsen, Ingunn Skogstad Riddervold, Thorbjørn Grøfte, Hans Kirkegaard, Bo Løfgren
BACKGROUND: Emergency dispatchers use protocols to instruct bystanders in cardiopulmonary resuscitation (CPR). Studies changing one element in the dispatcher's protocol report improved CPR quality. Whether several changes interact is unknown and the effect of combining multiple changes previously reported to improve CPR quality into one protocol remains to be investigated. We hypothesize that a novel dispatch protocol, combining multiple beneficial elements improves CPR quality compared with a standard protocol...
September 19, 2016: Resuscitation
https://www.readbyqxmd.com/read/27658622/transport-of-a-kinesin-cargo-pair-along-microtubules-into-dendritic-spines-undergoing-synaptic-plasticity
#13
Derrick P McVicker, Adam M Awe, Karl E Richters, Rebecca L Wilson, Diana A Cowdrey, Xindao Hu, Edwin R Chapman, Erik W Dent
Synaptic plasticity often involves changes in the structure and composition of dendritic spines. Vesicular cargos and organelles enter spines either by exocytosing in the dendrite shaft and diffusing into spines or through a kinesin to myosin hand-off at the base of spines. Here we present evidence for microtubule (MT)-based targeting of a specific motor/cargo pair directly into hippocampal dendritic spines. During transient MT polymerization into spines, the kinesin KIF1A and an associated cargo, synaptotagmin-IV (syt-IV), are trafficked in unison along MTs into spines...
2016: Nature Communications
https://www.readbyqxmd.com/read/27638418/introduction-of-paramedic-led-echo-in-life-support-into-the-pre-hospital-environment-the-puca-study
#14
Matthew J Reed, Louise Gibson, Alistair Dewar, Steven Short, Polly Black, Gareth R Clegg
OBJECTIVES: Can pre-hospital paramedic responders perform satisfactory pre-hospital Echo in Life Support (ELS) during the 10-second pulse check window, and does pre-hospital ELS adversely affect the delivery of cardiac arrest care. METHODS: Prospective observational study of a cohort of ELS trained paramedics using saved ultrasound clips and wearable camera videos. RESULTS: Between 23rd June 2014 and 31st January 2016, seven Resuscitation Rapid Response Unit (3RU) paramedics attended 45 patients in Lothian suffering out-of-hospital CA where resuscitation was attempted and ELS was available and performed...
September 13, 2016: Resuscitation
https://www.readbyqxmd.com/read/27637438/cardiopulmonary-resuscitation-quality-by-helicopter-rescue-swimmers-while-flying
#15
Cristian Abelairas-Gómez, Pablo Vázquez-González, Sergio López-García, José Palacios-Aguilar, Alexis Padrón-Cabo, Antonio Rodríguez-Núñez
OBJECTIVE: Our objective was to assess the cardiopulmonary resuscitation (CPR) quality by helicopter rescue swimmers (HRSs) while flying. METHODS: Twenty HRSs from the Spanish Maritime Safety took part in this study. The research protocol included 2 phases: a baseline test (5 minutes of CPR on land) and a challenge test (5 minutes of CPR on a Sikorsky S-61N helicopter in-flight). A Laerdal Resusci Anne mannequin with Laerdal PC Skill Reporting (Stavanger, Norway) was used to register CPR variables...
September 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27630885/quality-of-basic-life-support-a-comparison-between-medical-students-and-paramedics
#16
Maria Isabel Körber, Thomas Köhler, Verena Weiss, Roman Pfister, Guido Michels
INTRODUCTION: Poor survival rates after cardiac arrest can partly be explained by poor basic life support skills in medical professionals. AIM: This study aimed to assess quality of basic life support in medical students and paramedics. MATERIALS AND METHODS: We conducted a prospective observational study with 100 early medical students (group A), 100 late medical students (group B) and 100 paramedics (group C), performing a 20-minute basic life support simulation in teams of two...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27608067/reducing-prospective-memory-error-and-costs-in-simulated-air-traffic-control-external-aids-extending-practice-and-removing-perceived-memory-requirements
#17
Shayne Loft, Melissa Chapman, Rebekah E Smith
In air traffic control (ATC), forgetting to perform deferred actions-prospective memory (PM) errors-can have severe consequences. PM demands can also interfere with ongoing tasks (costs). We examined the extent to which PM errors and costs were reduced in simulated ATC by providing extended practice, or by providing external aids combined with extended practice, or by providing external aids combined with instructions that removed perceived memory requirements. Participants accepted/handed-off aircraft and detected conflicts...
September 2016: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/27561571/taking-stock-of-training-in-implant-dentistry
#18
F Barrak
Despite the ever-growing demand for implant treatments by patients, there is confusion about what the appropriate training pathway in implant dentistry should be. This is accompanied by a worrying lack of training at undergraduate level for correct patient selection and monitoring of implant cases. An unclear training pathway, inappropriate referrals and a 'hands-off' approach to patients with implants may be putting patients at risk. This article highlights these issues with a suggestion that the training should of course follow the current GDC guidelines, but goes further to suggest that the end point of training should be at diploma level as a minimum, either via a university route, or via the RCS Edinburgh Diploma in Implant Dentistry Examination...
August 26, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27551080/clues-to-the-mechanism-of-cholesterol-transfer-from-the-structure-of-npc1-middle-lumenal-domain-bound-to-npc2
#19
Xiaochun Li, Piyali Saha, Jian Li, Günter Blobel, Suzanne R Pfeffer
Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a soluble protein, Niemann-Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann-Pick disease type C (NPC). NPC2 binds to NPC1's second (middle), lumenally oriented domain (MLD) and transfers cholesterol to NPC1's N-terminal domain (NTD). Here, we report the 2.4-Å resolution crystal structure of a complex of human NPC1-MLD and NPC2 bearing bound cholesterol-3-O-sulfate...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27464394/hands-on-hands-off-midwifing-the-inner-life-of-women
#20
Sister MorningStar
No abstract text is available yet for this article.
2016: Midwifery Today with International Midwife
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