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Multiple Sclerosis exercise

James H Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine, Tapan Mehta
BACKGROUND: Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues. METHODS: Our Russian doll framework encompasses three study phases. Phase 1 involves prospectively following a cohort of participants with disability to examine the relationships between rates of health and functional deficits (e.g., pain, fatigue, deconditioning), functional measures (e...
March 14, 2018: BMC Medical Research Methodology
Bryan D Loy, Michelle H Cameron, Patrick J O'Connor
Persistent fatigue is a common problem (∼20-45% of U.S. population), with higher prevalence and severity in people with medical conditions such as cancer, depression, fibromyalgia, heart failure, sleep apnea and multiple sclerosis. There are few FDA-approved treatments for fatigue and great disagreement on how to measure fatigue, with over 250 instruments used in research. Many instruments define fatigue as "a lack of energy", thus viewing energy and fatigue states as opposites on a single bipolar continuum...
April 2018: Medical Hypotheses
Brian M Sandroff, Glenn R Wylie, Brad P Sutton, Curtis L Johnson, John DeLuca, Robert W Motl
Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus ( d  = 1.92) and left medial frontal gyrus ( d  = 1...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
M Mäurer, K Schuh, S Seibert, M Baier, C Hentschke, R Streber, A Tallner, K Pfeifer
Background: Fatigue is a major symptom of multiple sclerosis (MS) in patients, and it has been shown to improve with physical exercise. Although fingolimod might lessen fatigue, it is unclear how patients treated with fingolimod react to physical activity regarding fatigue. Objective: This study evaluated the effect of an exercise intervention on fatigue in relapsing-remitting MS patients receiving fingolimod. Methods: People with MS (PwMS) were randomized to either a structured internet-based exercise program (e-training) or no e-training intervention...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Charly Keytsman, Laura Blancquaert, Inez Wens, Maarten Missine, Pieter Van Noten, Frank Vandenabeele, Wim Derave, Bert O Eijnde
BACKGROUND: Muscle carnosine is related to contractile function (Ca ++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. METHODS: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAE EX , CON EX , 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE SED , CON SED )...
February 11, 2018: Multiple Sclerosis and related Disorders
Katie L Cederberg, Julia M Balto, Robert W Motl
OBJECTIVE: To examine self-regulation strategies as correlates of physical activity in persons with multiple sclerosis (MS). DESIGN: Cross-sectional, or survey, study. SETTING: University-based research laboratory. PARTICIPANTS: Convenience sample of 68 persons with MS. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Exercise Self-Efficacy Scale (EXSE), Physical Activity Self-Regulation Scale (PASR-12), and Godin Leisure-Time Exercise Questionnaire (GLTEQ)...
February 8, 2018: Archives of Physical Medicine and Rehabilitation
Shannon Charron, Kyla A McKay, Helen Tremlett
BACKGROUND: Physical activity may be neuroprotective in multiple sclerosis (MS). One review (2011) of exercise and MS disability was inconclusive, but highlighted the need for more studies. OBJECTIVE: To perform an updated systematic literature review examining the relationship between physical activity and physical ability outcomes in persons with MS. METHODS: EMBASE and MEDLINE were searched for original interventional studies (2011-2016) evaluating exercise on quantitative outcomes of physical disability in MS...
February 1, 2018: Multiple Sclerosis and related Disorders
Diana Veneri, Mary Gannotti, Matteo Bertucco, Sarah E Fournier Hillman
OBJECTIVE: Research pertaining to yoga and children with cerebral palsy (CP) is negligible. The primary purpose of this study was to determine the domains of the International Classification of Functioning, Disability, and Health (ICF) model and levels of evidence for yoga and adults with stroke and multiple sclerosis (MS), and children. A secondary purpose was to decide whether any inferences could be made for children with CP. DESIGN: This study included a meta-analysis...
February 6, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Jeffrey R Hebert, John R Corboy, Timothy Vollmer, Jeri E Forster, Margaret Schenkman
OBJECTIVE: To determine whether a multifaceted vestibular-related rehabilitation program (Balance and Eye-Movement Exercises for Persons with Multiple Sclerosis; BEEMS) improves balance in persons with MS and whether there are differences in outcomes based on brainstem/cerebellar lesion involvement. METHODS: A 2-arm, examiner-blinded, stratified (involvement vs no involvement of brainstem/cerebellar structures), randomized controlled trial was implemented. Eighty-eight participants were allocated to BEEMS or no treatment control...
January 31, 2018: Neurology
Robert W Motl, Elizabeth A Barstow, Sarah Blaylock, Emma Richardson, Yvonne C Learmonth, Matthew Fifolt
Participation in exercise yields meaningful benefits among persons with multiple sclerosis(MS), yet this population engages in low rates of health-promoting physical activity. The disconnect between evidence of benefits and rates of participation requires consideration of new opportunities for changing this health behavior. The current paper hypothesizes that the patient-provider interaction offers a fertile opportunity for promoting exercise behavior in MS.
January 15, 2018: Exercise and Sport Sciences Reviews
Elizabeth Morghen Sikes, Emma V Richardson, Katie J Cederberg, Jeffer E Sasaki, Brian M Sandroff, Robert W Motl
PURPOSE: The Godin Leisure-Time Exercise Questionnaire has been a commonly applied measure of physical activity in research among persons with multiple sclerosis over the past decade. This paper provides a comprehensive description of its application and inclusion in research on physical activity in multiple sclerosis. METHOD: This comprehensive, narrative review included papers that were published between 1985 and 2017, written in English, involved participants with multiple sclerosis as a primary population, measured physical activity, and cited one of the two original Godin papers...
January 17, 2018: Disability and Rehabilitation
Keira Byrnes, Ping-Jung Wu, Stephney Whillier
BACKGROUND: Pilates is a system of exercise focusing upon controlled movement, stretching and breathing. Pilates is popular today not only for physical fitness but also for rehabilitation programs. This paper is a review of the literature on the effectiveness of Pilates as a rehabilitation tool in a wide range of conditions in an adult population. METHODS: A systematic literature review was carried out according to the PRISMA guidelines. Electronic databases were searched for cohort studies or randomised controlled trials (RCTs), and inclusion and exclusion criteria were applied...
January 2018: Journal of Bodywork and Movement Therapies
C Ozkul, A Guclu-Gunduz, C Irkec, I Fidan, Y Aydin, T Ozkan, G Yazici
BACKGROUND: Suppressors of cytokine signaling (SOCS) and brain-derived neurotrophic factor (BDNF) are important immunologic, and neurotrophic factors for MS pathogenesis. The impact of exercise on these factors is yet to be fully elucidated in patients with MS. OBJECTIVE: The primary aim of this study is to investigate the effect of 8-week combined exercise training on serum concentrations of SOCS1, SOCS3, and BDNF. The secondary aim is to determine the effects of combined exercise training on balance, functional exercise capacity, and fatigue in patients with MS...
January 3, 2018: Journal of Neuroimmunology
Geetika Grover, Michelle Ploughman, Devin T Philpott, Liam P Kelly, Augustine J Devasahayam, Katie Wadden, Kevin E Power, Duane C Button
Background: Heat sensitivity and fatigue limit the ability of multiple sclerosis patients to participate in exercise. Objective: The purpose of this study was to determine the optimal aerobic exercise parameters (environmental temperature and exercise modality) to limit exercise-induced central and muscle fatigue among people with multiple sclerosis. Methods: Fourteen people with multiple sclerosis with varying levels of disability completed four randomized exercise sessions at 65% of the maximal volume of oxygen: body-weight supported treadmill cool (16°C), body-weight supported treadmill room (21°C), total-body recumbent stepper cool and total-body recumbent stepper room...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Winde Jorissen, Tim Vanmierlo, Inez Wens, Veerle Somers, Bart Van Wijmeersch, Jeroen F Bogie, Alan T Remaley, Bert O Eijnde, Jerome J A Hendriks
Multiple sclerosis (MS) is an inflammatory auto-immune disease of the central nervous system (CNS). Serum glucose alterations and impaired glucose tolerance (IGT) are reported in MS patients, and are commonly associated with the development of cardio-metabolic co-morbidities. We previously found that a subgroup of MS patients shows alterations in their lipoprotein profile that are similar to a pre-cardiovascular risk profile. In addition, we showed that a high-intensity exercise training has a positive effect on IGT in MS patients...
January 8, 2018: International Journal of Molecular Sciences
Eric R Reynolds, Andrew D Ashbaugh, Brandon J Hockenberry, Christopher A McGrew
Multiple sclerosis (MS) is the most common autoimmune disabling neurological conditions of young adults and affects more than 2.3 million people worldwide. Given the high likelihood for disability and decreased neurological function, there have been concerns about the role of exercise in MS patients with a fear of increased injury. This article looks at recent articles evaluating the role of exercise in MS and can hopefully be used by patients, caregivers, and health care providers to guide decision making about the role of exercise in patients with MS...
January 2018: Current Sports Medicine Reports
Manuel Rojas, Yhojan Rodriguez, Yovana Pacheco, Elizabeth Zapata, Diana M Monsalve, Rubén D Mantilla, Monica Rodríguez-Jimenez, Carolina Ramírez-Santana, Nicolás Molano-González, Juan-Manuel Anaya
OBJECTIVE: To evaluate the relationship between resilience and clinical outcomes in patients with autoimmune rheumatic diseases. METHODS: Focus groups, individual interviews, and chart reviews were done to collect data on 188 women with autoimmune rheumatic diseases, namely rheumatoid arthritis (n=51), systemic lupus erythematosus (n=70), systemic sclerosis (n=35), and Sjögren's syndrome (n=32). Demographic, clinical, and laboratory variables were assessed including disease activity by patient reported outcomes...
December 28, 2017: Joint, Bone, Spine: Revue du Rhumatisme
Robert W Motl, Brian M Sandroff
PURPOSE: The decline of central nervous system (CNS) function is a hallmark characteristic of multiple sclerosis (MS) that can manifest as cognitive impairment. We believe that exercise represents a potential behavioral approach for counteracting the declines in CNS structure and associated function among persons with MS (ie, exercise as a countermeasure of CNS decline). This theory is important because disease-modifying drugs represent a first-line approach for modifying the immune system and its effects on the CNS, but these drugs do not generally demonstrate robust improvements in cognitive performance...
December 26, 2017: Clinical Therapeutics
Alison Barry, Owen Cronin, Aisling M Ryan, Brian Sweeney, Orna O'Toole, Andrew P Allen, Gerard Clarke, Ken D O'Halloran, Eric J Downer
In this pilot study, we investigate whether a routine cycle ergometry training programme has therapeutic potential in individuals with multiple sclerosis (MS) by improving quality of life (QOL) and depressive symptomatology, while ameliorating cognitive disturbances. Healthy volunteers and MS patients cycled for 30 min at 65-75% age-predicted maximal heart rate on a recumbent ergometer, with this session repeated twice a week for 8 weeks. QOL, depressive symptomatology and cognitive function were assessed pre- and post-exercise using the MS Quality of Life-54 (MSQOL-54) questionnaire, 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16) questionnaire and the Cambridge Neuropsychological Test Automated Battery (CANTAB), respectively...
December 26, 2017: Neurological Sciences
Stine Maren Riksfjord, Siri Merete Brændvik, Ola D Røksund, Inger-Lise Aamot
Objectives: To assess ventilatory efficiency and aerobic capacity in people with multiple sclerosis and whether treadmill walking or progressive strength training has an effect on these parameters in this population. Methods: In all, 24 adults with multiple sclerosis with an Expanded Disability Status Scale score of ≤6 completed a cardiopulmonary exercise test before and after 8 weeks of exercise. They were randomized to treadmill walking of low-to-moderate intensity (50%-70% of peak heart rate) or progressive strength training (six repetitions × two at 80% of one repetition maximum)...
2017: SAGE Open Medicine
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