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Multiple Sclerosis exercise

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https://www.readbyqxmd.com/read/29775986/effects-of-two-training-programs-on-transcriptional-levels-of-neurotrophins-and-glial-cells-population-in-hippocampus-of-experimental-multiple-sclerosis
#1
Maryam Naghibzadeh, Rouhollah Ranjbar, Mohammad Reza Tabandeh, Abdolhamid Habibi
The aim of the present study was to investigate the effects of high-intensity interval training (HIIT) versus low-intensity continuous training (LICT) on transcriptional levels of neurotrophic factors and oligodendrocyte/microglia cell loss in a cuprizone (CP) induced animal model of demyelination. Male C57BL/6 mice were assigned to six groups: control (C), cuprizone-induced demyelination (CP), interval training (IT), continuous training (CT), IT plus CP (ITCP), and CT plus CP (CTCP). Training programs on the treadmill were performed for four weeks, and then demyelination was induced by feeding mice a diet containing 0...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29772185/therapies-for-mobility-disability-in-persons-with-multiple-sclerosis
#2
Jessica F Baird, Brian M Sandroff, Robert W Motl
Mobility disability is one of the most widespread and impactful consequences of multiple sclerosis (MS). Disease modifying drugs (DMDs) may delay the progression of disability over time; however, there is minimal evidence supporting the efficacy of DMDs for reversing mobility disability or restoring ambulatory function in persons with MS. Areas covered: This review outlines symptomatic pharmacologic and non-pharmacologic therapeutic approaches that target mobility disability with the goal of restoring and improving walking function...
May 17, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29771367/effectiveness-of-and-user-experience-with-web-based-interventions-in-increasing-physical-activity-levels-in-people-with-multiple-sclerosis-a-systematic-review
#3
Rachel Dennett, Hilary Gunn, Jennifer A Freeman
Background: Supporting people with multiple sclerosis (MS) to achieve and maintain recommended levels of physical activity is important but challenging. Web-based interventions are increasingly being used to deliver targeted exercise programs and promote physical activity. Purpose: The purpose of this study was to systematically review current evidence regarding the effectiveness and user experience of web-based interventions in increasing physical activity in people with MS...
May 15, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29748963/body-mass-index-and-cardiorespiratory-fitness-in-persons-with-multiple-sclerosis
#4
E Sebastião, R W Motl
OBJECTIVE: This study examined body fatness and its association with cardiorespiratory fitness (CRF) in persons with multiple sclerosis (pwMS) accounting for disability status. MATERIALS AND METHODS: This study involved a secondary data analysis from a previous study of 62 pwMS. Body fatness was indirect measured as body mass index (BMI), and CRF was measured as peak oxygen consumption from an incremental exercise test with spirometry. Participants were allocated into 3 different groups based on established BMI categories (ie, normal, overweight, and obese), and data were analyzed using SPSS...
May 11, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29745872/effects-of-autonomic-dysfunction-on-exercise-tolerance-in-systemic-sclerosis-patients-without-clinical-and-instrumental-evidence-of-cardiac-and-pulmonary-involvement
#5
Marcello Di Paolo, Antonietta Gigante, Marta Liberatori, Liborio Sardo, Paolo Marinelli, Marco Rossetti, Paolo Palange, Luigi Tubani, Edoardo Rosato
OBJECTIVES: Autonomic dysfunction (AD) in systemic sclerosis (SSc) was already confirmed through heart rate variability (HRV) analysis. Cardio-pulmonary exercise testing (CPET) is a useful tool in early detection of exercise tolerance in SSc patients. Aim of the study was to assess the relationships existing between AD and exercise tolerance. METHODS: Thirty-two [4 M, 28 F; median age: 47.5 (20-65) years] consecutive SSc patients were enrolled. All patients underwent pulmonary function testing, incremental symptom-limited CPET and twenty-four hours ECG Holter recording with HRV analysis in time and frequency domain...
May 4, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29727394/lower-aerobic-endurance-linked-to-history-of-depression-in-multiple-sclerosis-preliminary-observations
#6
Kimberly R Chapman, Jason R Anderson, Dayana Calvo, Brandon S Pollock, Jennifer Petersen, Hayden Gerhart, Angela Ridgel, Mary Beth Spitznagel
BACKGROUND: Despite the demonstrated benefits of exercise in multiple sclerosis (MS), this population shows low rates of physical activity. Understanding barriers to exercise in persons with MS is important. The current study examined the relationship between lifetime history of depression, current depressive symptoms, and aerobic endurance in persons with relapsing-remitting MS to determine whether depression might be one such barrier. METHODS: Thirty-one participants with relapsing-remitting MS self-reported current depressive symptoms and history of depression...
June 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29705471/acute-responses-of-cytokines-and-adipokines-to-aerobic-exercise-in-relapsing-vs-remitting-women-with-multiple-sclerosis
#7
Nastaran Majdinasab, Robert W Motl, Motahare Mokhtarzade, Philipp Zimmer, Rouholah Ranjbar, Charly Keytsman, Tom Cullen, Raoof Negaresh, Julien S Baker
OBJECTIVE: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). METHODS: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29696187/feasibility-study-design-and-methods-for-a-home-based-square-stepping-exercise-program-among-older-adults-with-multiple-sclerosis-the-sse-ms-project
#8
Emerson Sebastião, Edward McAuley, Ryosuke Shigematsu, Robert W Motl
We propose a randomized controlled trial (RCT) examining the feasibility of square-stepping exercise (SSE) delivered as a home-based program for older adults with multiple sclerosis (MS). We will assess feasibility in the four domains of process, resources, management and scientific outcomes. The trial will recruit older adults (aged 60 years and older) with mild-to-moderate MS-related disability who will be randomized into intervention or attention control conditions. Participants will complete assessments before and after completion of the conditions delivered over a 12-week period...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29670495/impact-of-pilates-exercise-in-multiple-sclerosis-a-randomized-controlled-trial
#9
Whitney R D Duff, Justin W Andrushko, Doug W Renshaw, Philip D Chilibeck, Jonathan P Farthing, Jana Danielson, Charity D Evans
Background: Pilates is a series of exercises based on whole-body movement and may improve mobility in people with multiple sclerosis (MS). The purpose of this study was to determine the effect of Pilates on walking performance in people with MS. Methods: 30 individuals with MS who were not restricted to a wheelchair or scooter (Patient-Determined Disease Steps scale score <7) were randomized to receive Pilates (twice weekly) and massage therapy (once weekly) or once-weekly massage therapy only (control group)...
March 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29666705/the-role-of-moderate-aerobic-exercise-as-determined-by-cardiopulmonary-exercise-testing-in-als
#10
Anna Caroline Marques Braga, Anabela Pinto, Susana Pinto, Mamede de Carvalho
Introduction: The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention. Methods: We included 48 ALS patients randomized in 2 groups: G1 ( n = 24), exercise intensity leveled by CPET; G2 ( n = 24), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission ( T 1) and 6 months later ( T 2)...
2018: Neurology Research International
https://www.readbyqxmd.com/read/29618280/progressive-resistance-exercise-training-and-changes-in-resting-state-functional-connectivity-of-the-caudate-in-persons-with-multiple-sclerosis-and-severe-fatigue-a-proof-of-concept-study
#11
Nadine Akbar, Brian M Sandroff, Glenn R Wylie, Lauren B Strober, Angela Smith, Yael Goverover, Robert W Motl, John DeLuca, Helen Genova
Fatigue is one of the most disabling symptoms of multiple sclerosis (MS). While progressive resistance training (PRT) has been shown to reduce fatigue in persons with MS, it is not clear why these reductions occur. One hypothesis is that PRT may induce functional changes to the caudate, a region highly implicated in MS fatigue. The aim of the current study was to study the effects of PRT on overall fatigue impact and resting-state functional connectivity of the caudate in persons with MS reporting severe fatigue...
April 4, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29609662/considerations-for-expanding-community-exercise-programs-incorporating-a-healthcare-recreation-partnership-for-people-with-balance-and-mobility-limitations-a-mixed-methods-evaluation
#12
Nancy M Salbach, Jo-Anne Howe, Diem Baldry, Saira Merali, Sarah E P Munce
OBJECTIVE: To increase access to safe and appropriate exercise for people with balance and mobility limitations, community organizations have partnered with healthcare providers to deliver an evidence-based, task-oriented group exercise program in community centers in Canada. We aimed to understand challenges and solutions to implementing this program model to inform plans for expansion. RESULTS: At a 1-day meeting, 53 stakeholders (healthcare/recreation personnel, program participants/caregivers, researchers) identified challenges to program implementation that were captured by seven themes: Resources to deliver the exercise class (e...
April 2, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29596685/activity-matters-a-web-based-resource-to-enable-people-with-multiple-sclerosis-to-become-more-active
#13
Blathin Casey, Susan Coote, Molly Byrne
Increasing physical activity (PA) through exercise is associated with improvements in many of the symptoms associated with multiple sclerosis (MS) such as fatigue, strength, balance, and mobility. Despite this, people with MS remain largely inactive. Interventions that are grounded in theory and that aim to change PA behavior need to be developed. The purpose of this study was to describe the development process of a web-based resource, namely, "Activity Matters," to enable people with MS to become more active...
March 27, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29595826/pediatric-multiple-sclerosis-current-perspectives-on-health-behaviors
#14
REVIEW
Elizabeth Morghen Sikes, Robert W Motl, Jayne M Ness
Purpose: Pediatric-onset multiple sclerosis (POMS) accounts for ~5% of all multiple sclerosis cases, and has a prevalence of ~10,000 children in the USA. POMS is associated with a higher relapse rate, and results in irreversible disability on average 10 years earlier than adult-onset multiple sclerosis. Other manifestations of POMS include mental and physical fatigue, cognitive impairment, and depression. We believe that the health behaviors of physical activity, diet, and sleep may have potential benefits in POMS, and present a scoping review of the existing literature...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29574556/fatigue-as-measured-using-the-modified-fatigue-impact-scale-is-a-predictor-of-processing-speed-improvement-induced-by-exercise-in-patients-with-multiple-sclerosis-data-from-a-randomized-controlled-trial
#15
Giancarlo Coghe, Federica Corona, Elisabetta Marongiu, Giuseppe Fenu, Jessica Frau, Lorena Lorefice, Antonio Crisafulli, Manuela Galli, Alberto Concu, Maria Giovanna Marrosu, Massimiliano Pau, Eleonora Cocco
BACKGROUND: Few studies have evaluated the impact of physical activity (PA) on cognition and fatigue, and none have considered the effects of PA on the relationship between cognition and fatigue. OBJECTIVES: We evaluated the effect of PA in people with multiple sclerosis (pwMS) in a 6-month-long single-blind randomized controlled trial. We focused on the impact of exercise on cognition, fatigue, and the relationship between cognition and fatigue. METHODS: We recruited pwMS, who were then randomly assigned 1:1 to either a PA protocol group or a control group (CG)...
March 24, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29563533/profiling-walking-dysfunction-in-multiple-sclerosis-characterisation-classification-and-progression-over-time
#16
Linard Filli, Tabea Sutter, Christopher S Easthope, Tim Killeen, Christian Meyer, Katja Reuter, Lilla Lörincz, Marc Bolliger, Michael Weller, Armin Curt, Dominik Straumann, Michael Linnebank, Björn Zörner
Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology in gait-impaired patients with MS using comprehensive 3D gait analysis and clinical walking tests. Thirty-seven patients with MS walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects walked at all the different patient's paces, allowing for comparisons independent of walking velocity. Kinematic analysis revealed pronounced restrictions in knee and ankle joint excursion, increased gait variability and asymmetry along with impaired dynamic stability in patients...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29553785/do-multiple-sclerosis-symptoms-moderate-the-relationship-between-self-efficacy-and-physical-activity-in-people-with-multiple-sclerosis
#17
Blathin Casey, Marcin Uszynski, Sara Hayes, Robert Motl, Stephen Gallagher, Susan Coote
OBJECTIVE: To investigate the bivariate correlations between objective physical activity (PA), self-efficacy, and a range of multiple sclerosis (MS) symptom measures. Also, to determine whether any MS symptom measures moderate the relationship between self-efficacy and PA. METHOD: Baseline analysis from a randomized control trial exercise plus a behavior change intervention was used. Fifty-nine physically inactive people with a definite diagnosis of MS were included...
February 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29540164/methodological-and-clinical-implications-of-a-three-in-one-russian-doll-design-for-tracking-health-trajectories-and-improving-health-and-function-through-innovative-exercise-treatments-in-adults-with-disability
#18
James H Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine, Tapan Mehta
BACKGROUND: Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues. METHODS: Our Russian doll framework encompasses three study phases. Phase 1 involves prospectively following a cohort of participants with disability to examine the relationships between rates of health and functional deficits (e.g., pain, fatigue, deconditioning), functional measures (e...
March 14, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29523293/perceived-fatigue-and-energy-are-independent-unipolar-states-supporting-evidence
#19
Bryan D Loy, Michelle H Cameron, Patrick J O'Connor
Persistent fatigue is a common problem (∼20-45% of U.S. population), with higher prevalence and severity in people with medical conditions such as cancer, depression, fibromyalgia, heart failure, sleep apnea and multiple sclerosis. There are few FDA-approved treatments for fatigue and great disagreement on how to measure fatigue, with over 250 instruments used in research. Many instruments define fatigue as "a lack of energy", thus viewing energy and fatigue states as opposites on a single bipolar continuum...
April 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29497559/treadmill-walking-exercise-training-and-brain-function-in-multiple-sclerosis-preliminary-evidence-setting-the-stage-for-a-network-based-approach-to-rehabilitation
#20
Brian M Sandroff, Glenn R Wylie, Brad P Sutton, Curtis L Johnson, John DeLuca, Robert W Motl
Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus ( d  = 1.92) and left medial frontal gyrus ( d  = 1...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
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