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https://www.readbyqxmd.com/read/29284512/quantifying-the-learning-curve-for-pulmonary-thromboendarterectomy
#1
Smita Sihag, Bao Le, Alison S Witkin, Josanna M Rodriguez-Lopez, Mauricio A Villavicencio, Gus J Vlahakes, Richard N Channick, Cameron D Wright
BACKGROUND: Pulmonary thromboendarterectomy (PTE) is an effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH), but is a technically challenging operation for cardiothoracic surgeons. Starting a new program allows an opportunity to define a learning curve for PTE. METHODS: A retrospective case review was performed of 134 consecutive PTEs performed from 1998 to 2016 at a single institution. Outcomes were compared using either a two-tailed t-test for continuous variables or a chi-squared test for categorical variables according to experience of the program by terciles (T)...
December 28, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29247544/removal-of-hemangiosarcoma-cells-from-canine-blood-with-a-cell-salvage-system-and-leukocyte-reduction-filter
#2
Brittany Ciepluch, Heather Wilson-Robles, Gwendolyn Levine, Roger Smith, Gus A Wright, Tasha Miller, Maureen T O'Brien, Kelley M Thieman Mankin
OBJECTIVE: To determine the ability of an intraoperative cell salvage (IOCS) system and a leukocyte reduction filter (LRF) to remove hemangiosarcoma (HSA) cells from canine blood. STUDY DESIGN: Cultured HSA cells were added to canine blood to simulate intraoperative hemorrhage and address hemoabdomen from ruptured splenic HSA. The blood/HSA cell mixture was processed through an IOCS, followed by LRF processing. SAMPLE POPULATION: Whole blood from 3 healthy dogs combined with cultured HSA cells...
December 16, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29233896/retargeting-lentiviruses-via-spycatcher-spytag-chemistry-for-gene-delivery-into-specific-cell-types
#3
Nagarjun Kasaraneni, Ana M Chamoun-Emanuelli, Gus Wright, Zhilei Chen
We report a simple strategy for the creation of lentiviral vectors specific to any desired target cells. SpyTag is inserted into an engineered Sindbis virus envelope protein and displayed on the lentivirus surface to create Sindbis virus-SpyTag pseudoparticles (Sind-SpyTag-pp). The SpyTag serves as the covalent anchoring site for a target-cell-specific cell-binding protein (CBP) that is fused to a truncated SpyCatcher (SpyCatcherΔ). Target-cell-specific lentiviruses are created by mixing the Sind-SpyTag-pp and CBP-SpyCatcherΔ in vitro We first used a HER2-binding designed ankyrin repeat protein (DARPin...
December 12, 2017: MBio
https://www.readbyqxmd.com/read/29217004/transapical-transcatheter-aortic-valve-replacement-is-associated-with-increased-cardiac-mortality-in-patients-with-left%C3%A2-ventricular-dysfunction-insights-from-the-partner-i-trial
#4
Sammy Elmariah, William F Fearon, Ignacio Inglessis, Gus J Vlahakes, Brian R Lindman, Maria C Alu, Aaron Crowley, Susheel Kodali, Martin B Leon, Lars Svensson, Philippe Pibarot, Rebecca T Hahn, Vinod H Thourani, Igor F Palacios, D Craig Miller, Pamela S Douglas, Jonathan J Passeri
OBJECTIVES: The authors sought to evaluate the impact of transapical (TA) transcatheter aortic valve replacement (TAVR) on mortality, left ventricular (LV) ejection fraction (LVEF) improvement, and functional recovery in patients with LV dysfunction. BACKGROUND: LV injury inherent to TA access for structural heart disease interventions may be particularly detrimental to the LV, functional recovery, and survival in patients with LV dysfunction. METHODS: The study included patients enrolled within the PARTNER I (Placement of Aortic Transcatheter Valves) trial that underwent transfemoral (TF) or TA TAVR...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29215527/long-term-trends-in-singleton-preterm-birth-in-south-australia-from-1986-to-2014
#5
Petra E Verburg, Gus A Dekker, Kamalesh Venugopal, Wendy Scheil, Jan Jaap H M Erwich, Ben W Mol, Claire T Roberts
OBJECTIVE: To describe long-term trends in the prevalence of preterm birth and rates of preterm birth in singleton pregnancies complicated by hypertensive disorders of pregnancy, small for gestational age (SGA), and preterm prelabor rupture of membranes (PROM) in South Australia. METHODS: We conducted a retrospective population study including all singleton live births in the state of South Australia from 1986 to 2014. Long-term trends for preterm birth, hypertensive disorders of pregnancy, SGA, preterm PROM as well as stillbirth were assessed using joinpoint regression analyses...
January 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29191914/resolvins-suppress-tumor-growth-and-enhance-cancer-therapy
#6
Megan L Sulciner, Charles N Serhan, Molly M Gilligan, Dayna K Mudge, Jaimie Chang, Allison Gartung, Kristen A Lehner, Diane R Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P Sukhatme, Arja Kaipainen, Mark W Kieran, Sui Huang, Dipak Panigrahy
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release after phosphatidylserine exposure...
November 30, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29182530/nodule-enriched-gretchen-hagen-3-enzymes-have-distinct-substrate-specificities-and-are-important-for-proper-soybean-nodule-development
#7
Suresh Damodaran, Corey S Westfall, Brian A Kisely, Joseph M Jez, Senthil Subramanian
Legume root nodules develop as a result of a symbiotic relationship between the plant and nitrogen-fixing rhizobia bacteria in soil. Auxin activity is detected in different cell types at different stages of nodule development; as well as an enhanced sensitivity to auxin inhibits, which could affect nodule development. While some transport and signaling mechanisms that achieve precise spatiotemporal auxin output are known, the role of auxin metabolism during nodule development is unclear. Using a soybean root lateral organ transcriptome data set, we identified distinct nodule enrichment of three genes encoding auxin-deactivating GRETCHEN HAGEN 3 (GH3) indole-3-acetic acid (IAA) amido transferase enzymes: GmGH3-11/12, GmGH3-14 and GmGH3-15...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29161311/expression-and-regulation-of-atl9-an-e3-ubiquitin-ligase-involved-in-plant-defense
#8
Fengyan Deng, Tingwei Guo, Mitchell Lefebvre, Steven Scaglione, Christopher J Antico, Tao Jing, Xin Yang, Weixing Shan, Katrina M Ramonell
Plants are continually exposed to a variety of pathogenic organisms, including bacteria, fungi and viruses. In response to these assaults, plants have developed various defense pathways to protect themselves from pathogen invasion. An understanding of the expression and regulation of genes involved in defense signaling is essential to controlling plant disease. ATL9, an Arabidopsis RING zinc finger protein, is an E3 ubiquitin ligase that is induced by chitin and involved in basal resistance to the biotrophic fungal pathogen, Golovinomyces cichoracearum (G...
2017: PloS One
https://www.readbyqxmd.com/read/29151075/formation-of-new-blood-vessels-during-gastric-ulcer-healing-role-of-bone-marrow-derived-endothelial-progenitor-cells
#9
A Ahluwalia, T Brzozowski, M K Jones, Y Ichikawa, A S Tarnawski
Regeneration of blood vessels (neovascularization) is critical for gastric ulcer (GU) healing. The contributions of bone marrow-derived endothelial progenitor cells (BMD-EPCs) to neovascularization during GU healing are not fully elucidated. Our specific aims were to determine whether in GU, BMD-EPCs are incorporated into blood vessels of GU granulation tissue jointly with ECs, thus forming hybrid vessels; or, form separate vessels consisting of only BMD-EPCs. GUs were induced in rats by serosal application of acetic acid...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29074714/potential-for-non-invasive-assessment-of-lung-inhomogeneity-using-highly-precise-highly-time-resolved-measurements-of-gas-exchange
#10
James E Mountain, Peter Santer, David Patrick O'Neill, Nicholas M J Smith, Luca Ciaffoni, John H Couper, Grant A D Ritchie, Gus Hancock, Jonathan P Whiteley, Peter A Robbins
Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesised that highly precise measurements of gas exchange contain sufficient information to quantify many aspects of the inhomogeneity non-invasively. Our aim was to explore whether one parameterization of lung inhomogeneity could both fit such data and provide reliable parameter estimates. A mathematical model of gas exchange in an inhomogeneous lung was developed, containing inhomogeneity parameters for compliance, vascular conductance and deadspace, all relative to lung volume...
October 26, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29042210/the-physicochemical-basis-of-clofazimine-induced-skin-pigmentation
#11
Mikhail D Murashov, Vernon LaLone, Phillip M Rzeczycki, Rahul K Keswani, Gi S Yoon, Sudha Sud, Walajapet Rajeswaran, Scott Larsen, Kathleen A Stringer, Gus R Rosania
Clofazimine is a weakly basic, FDA-approved antibiotic recommended by the World Health Organization to treat leprosy and multi-drug-resistant tuberculosis. Upon prolonged treatment, clofazimine extensively bioaccumulates and precipitates throughout the organism, forming crystal-like drug inclusions (CLDIs). Because of the drug's red color, it is widely believed that clofazimine bioaccumulation results in skin pigmentation, its most common side effect. To test whether clofazimine-induced skin pigmentation is due to CLDI formation, we synthesized a closely related clofazimine analog that does not precipitate under physiological pH and chloride conditions that are required for CLDI formation...
October 14, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29028482/adiposity-phenotypes-are-associated-with-type-2-diabetes-lap-index-body-adiposity-index-and-neck-circumference
#12
Aline Marcadenti, Flavio D Fuchs, Leila B Moreira, Miguel Gus, Sandra C Fuchs
BACKGROUND AND AIMS: Adiposity phenotypes can be detected by anthropometric indexes associated with type-2 diabetes mellitus (T2DM). Besides body mass index (BMI) and waist circumference (WC), new indices seem to be able to identify T2DM. This study aimed to evaluate independent associations of T2DM with lipid accumulation product (LAP index), neck circumference (NC) and body adiposity index (BAI) in patients with hypertension. METHODS: A cross-sectional study was carried out among 430 patients with hypertension...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28993784/the-intergenic-interplay-between-aldose-1-epimerase-like-protein-and-pectin-methylesterase-in-abiotic-and-biotic-stress-control
#13
Ekaterina V Sheshukova, Tatiana V Komarova, Denis V Pozdyshev, Natalia M Ershova, Anastasia V Shindyapina, Vadim N Tashlitsky, Eugene V Sheval, Yuri L Dorokhov
The mechanical damage that often precedes the penetration of a leaf by a pathogen promotes the activation of pectin methylesterase (PME); the activation of PME leads to the emission of methanol, resulting in a "priming" effect on intact leaves, which is accompanied by an increased sensitivity to Tobacco mosaic virus (TMV) and resistance to bacteria. In this study, we revealed that mRNA levels of the methanol-inducible gene encoding Nicotiana benthamiana aldose 1-epimerase-like protein (NbAELP) in the leaves of intact plants are very low compared with roots...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28893220/the-added-value-of-musculoskeletal-ultrasound-to-clinical-evaluation-in-the-treatment-decision-of-rheumatoid-arthritis-outpatients-physician-experience-matters
#14
C Sifuentes-Cantú, I Contreras-Yáñez, L Saldarriaga, A C Lozada, M Gutiérrez, V Pascual-Ramos
BACKGROUND: Musculoskeletal ultrasound improves the accuracy of detecting the level of disease activity (DA) in RA patients, although its impact on the final treatment decision in a real clinical setting is uncertain. The objectives were to define the percentage of clinical scenarios from an ongoing cohort of RA outpatients in which the German Ultrasound Score on 7 joints (GUS-7) impacted the treatment and to explore if the impact differed between a senior rheumatologist (SR) vs. a trainee (TR)...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28878804/the-latex-protein-mlx56-from-mulberry-morus-multicaulis-protects-plants-against-insect-pests-and-pathogens
#15
Ying-Ping Gai, Ya-Nan Zhao, Huai-Ning Zhao, Chuan-Zhong Yuan, Shuo-Shuo Yuan, Shuo Li, Bing-Sen Zhu, Xian-Ling Ji
Biotic stresses are major constraints limiting the leaf quality and productivity of mulberry. MLX56 is a unique chitin-binding protein isolated from Shin-Ichinose (Morus alba) latex that displays toxicity against lepidopteran caterpillars. In this study, the full-length cDNA encoding MLX56 was isolated from Husang 32 (M. multicaulis) and designated HMLX56. Amino acid sequence analysis and protein modeling of three MLX56 proteins showed that they were highly conserved among Morus species. Tissue expression pattern analysis showed that the HMLX56 gene was strongly expressed in mulberry bark and leaves but only slightly expressed in fruits...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28878506/analysis-of-tandem-repeat-units-of-the-promoter-of-capsanthin-capsorubin-synthase-ccs-gene-in-pepper-fruit
#16
Shi-Lin Tian, Zheng Li, Li Li, S N M Shah, Zhen-Hui Gong
Capsanthin/capsorubin synthase (Ccs) gene is a key gene that regulates the synthesis of capsanthin and the development of red coloration in pepper fruits. There are three tandem repeat units in the promoter region of Ccs, but the potential effects of the number of repetitive units on the transcriptional regulation of Ccs has been unclear. In the present study, expression vectors carrying different numbers of repeat units of the Ccs promoter were constructed, and the transient expression of the β-glucuronidase (GUS) gene was used to detect differences in expression levels associated with the promoter fragments...
July 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28842561/construction-and-in-vivo-assembly-of-a-catalytically-proficient-and-hyperthermostable-de-novo-enzyme
#17
Daniel W Watkins, Jonathan M X Jenkins, Katie J Grayson, Nicola Wood, Jack W Steventon, Kristian K Le Vay, Matthew I Goodwin, Anna S Mullen, Henry J Bailey, Matthew P Crump, Fraser MacMillan, Adrian J Mulholland, Gus Cameron, Richard B Sessions, Stephen Mann, J L Ross Anderson
Although catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of reaction chemistries in re-engineered native proteins has proved challenging. Wholesale modification of natural enzymes is potentially compromised by their intrinsic complexity, which often obscures the underlying principles governing biocatalytic efficiency. The maquette approach can circumvent this complexity by combining a robust de novo designed chassis with a design process that avoids atomistic mimicry of natural proteins...
August 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28755726/the-underappreciated-doctors-of-the-american-civil-rights-movement-part-i-theodore-roosevelt-mason-howard-md
#18
EDITORIAL
Richard D deShazo, Sara B Parker
During the fight to end segregation in the United States, most of the 25 or so black physicians who had not already left Mississippi took risks to become active in civil rights locally and nationally. One of the first was T.R.M. Howard, MD, whose life story is both an encouragement and warning for today's physicians. Howard, the protégé of a white Adventist physician, became active in civil rights during medical school. While serving as chief surgeon of the all-black hospital in Mississippi, he formed his own civil rights organization in 1951 and worked to solve the shootings of 2 of its members, George Lee and Gus Courts, and the murder of Emmett Till in 1955...
July 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28755354/transient-gus-gene-expression-in-date-palm-fruit-using-agroinjection-transformation-technique
#19
Mohei El-Din M Solliman, Hebaallah A Mohasseb, Abdullatif A Al-Khateeb, Jameel M Al-Khayri, Suliman A Al-Khateeb
Transient expression of foreign genes in plant tissue is a valuable tool for testing the efficacy of transformation methods. In this work, we present, for the first time, the utilization of agroinjection as an efficient transformation system for gene delivery in date palm fruit. The research utilized Agrobacterium tumefaciens strain LBA4404 harboring the binary vector pRI201-AN-GUS carrying the beta-glucuronidase (GUS) gene, under the control of a CaMV 35S and kanamycin (NPTII) as an antibiotic gene under the control of a NOS promoter...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28746737/divergent-expression-of-cytokinin-biosynthesis-signaling-and-catabolism-genes-underlying-differences-in-feeding-sites-induced-by-cyst-and-root-knot-nematodes
#20
Carola D Dowd, Demosthenis Chronis, Zoran S Radakovic, Shahid Siddique, Thomas Schmülling, Tomáš Werner, Tatsuo Kakimoto, Florian M W Grundler, Melissa G Mitchum
Cyst and root-knot nematodes are obligate parasites of economic importance with a remarkable ability to reprogram root cells into unique metabolically active feeding sites. Previous studies have suggested a role for cytokinin in feeding site formation induced by these two types of nematodes, but the mechanistic details have not yet been described. Using Arabidopsis as a host plant species, we conducted a comparative analysis of cytokinin genes in response to the beet cyst nematode (BCN), Heterodera schachtii, and the root-knot nematode (RKN), Meloidogyne incognita...
July 26, 2017: Plant Journal: for Cell and Molecular Biology
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