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https://www.readbyqxmd.com/read/29773331/novel-use-of-viewray-mri-guidance-for-high-dose-rate-brachytherapy-in-the-treatment-of-cervical-cancer
#1
Huaising C Ko, Jessie Y Huang, Jessica R Miller, Rupak K Das, Charles R Wallace, Anna-Maria A De Costa, David M Francis, Margaret R Straub, Bethany M Anderson, Kristin A Bradley
PURPOSE: To characterize image quality and feasibility of using ViewRay MRI (VR)-guided brachytherapy planning for cervical cancer. METHODS AND MATERIALS: Cervical cancer patients receiving intracavitary brachytherapy with tandem and ovoids, planned using 0.35T VR MRI at our institution, were included in this series. The high-risk clinical target volume (HR-CTV), visible gross tumor volume, bladder, sigmoid, bowel, and rectum contours for each fraction of brachytherapy were evaluated for dosimetric parameters...
May 14, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29755679/microrna-profiles-in-urine-by-next-generation-sequencing-can-stratify-bladder-cancer-subtypes
#2
Barbara Pardini, Francesca Cordero, Alessio Naccarati, Clara Viberti, Giovanni Birolo, Marco Oderda, Cornelia Di Gaetano, Maddalena Arigoni, Federica Martina, Raffaele A Calogero, Carlotta Sacerdote, Paolo Gontero, Paolo Vineis, Giuseppe Matullo
Bladder cancer (BC) is the most frequent malignancy of the urinary tract with a high incidence in men and smokers. Currently, there are no non-invasive markers useful for BC diagnosis and subtypes classification that could overcome invasive procedures such as cystoscopy. Dysregulated miRNA profiles have been associated with numerous cancers, including BC. Cell-free miRNAs are abundantly present in a variety of biofluids including urine and make them promising candidates in cancer biomarker discovery. In the present study, the identification of miRNA fingerprints associated with different BC status was performed by next-generation sequencing on urine samples from 66 BC and 48 controls...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29746834/characterization-of-bk-polyomaviruses-from-kidney-transplant-recipients-suggests-a-role-for-apobec3-in-driving-in-host-virus-evolution
#3
Alberto Peretti, Eileen M Geoghegan, Diana V Pastrana, Sigrun Smola, Pascal Feld, Marlies Sauter, Stefan Lohse, Mayur Ramesh, Efrem S Lim, David Wang, Cinzia Borgogna, Peter C FitzGerald, Valery Bliskovsky, Gabriel J Starrett, Emily K Law, Reuben S Harris, J Keith Killian, Jack Zhu, Marbin Pineda, Paul S Meltzer, Renzo Boldorini, Marisa Gariglio, Christopher B Buck
BK polyomavirus (BKV) frequently causes nephropathy (BKVN) in kidney transplant recipients (KTRs). BKV has also been implicated in the etiology of bladder and kidney cancers. We characterized BKV variants from two KTRs who developed BKVN followed by renal carcinoma. Both patients showed a swarm of BKV sequence variants encoding non-silent mutations in surface loops of the viral major capsid protein. The temporal appearance and disappearance of these mutations highlights the intra-patient evolution of BKV. Some of the observed mutations conferred resistance to antibody-mediated neutralization...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29742009/multicenter-prospective-phase-ii-trial-of-neoadjuvant-dose-dense-gemcitabine-plus-cisplatin-in-patients-with-muscle-invasive-bladder-cancer
#4
Gopa Iyer, Arjun V Balar, Matthew I Milowsky, Bernard H Bochner, Guido Dalbagni, S Machele Donat, Harry W Herr, William C Huang, Samir S Taneja, Michael Woods, Irina Ostrovnaya, Hikmat Al-Ahmadie, Maria E Arcila, Jamie C Riches, Andreas Meier, Caitlin Bourque, Maha Shady, Helen Won, Tracy L Rose, William Y Kim, Brooke E Kania, Mariel E Boyd, Catharine K Cipolla, Ashley M Regazzi, Daniela Delbeau, Asia S McCoy, Hebert Alberto Vargas, Michael F Berger, David B Solit, Jonathan E Rosenberg, Dean F Bajorin
Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin-based regimens have yielded favorable outcomes compared with standard-dose chemotherapy, yet the optimal neoadjuvant regimen remains undefined. We assessed the efficacy and tolerability of six cycles of neoadjuvant dose-dense gemcitabine and cisplatin (ddGC) in patients with MIBC. Patients and Methods In this prospective, multicenter phase II study, patients received ddGC (gemcitabine 2,500 mg/m2 on day 1 and cisplatin 35 mg/m2 on days 1 and 2) every 2 weeks for 6 cycles followed by RC...
May 9, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29729848/development-and-validation-of-a-28-gene-hypoxia-related-prognostic-signature-for-localized-prostate-cancer
#5
Lingjian Yang, Darren Roberts, Mandeep Takhar, Nicholas Erho, Becky A S Bibby, Niluja Thiruthaneeswaran, Vinayak Bhandari, Wei-Chen Cheng, Syed Haider, Amy M B McCorry, Darragh McArt, Suneil Jain, Mohammed Alshalalfa, Ashley Ross, Edward Schaffer, Robert B Den, R Jeffrey Karnes, Eric Klein, Peter J Hoskin, Stephen J Freedland, Alastair D Lamb, David E Neal, Francesca M Buffa, Robert G Bristow, Paul C Boutros, Elai Davicioni, Ananya Choudhury, Catharine M L West
BACKGROUND: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. METHOD: Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON)...
April 23, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29727914/germline-mutations-in-dna-repair-genes-are-associated-with-bladder-cancer-risk-and-unfavorable-prognosis
#6
Rong Na, Yishuo Wu, Guangliang Jiang, Hongjie Yu, Xiaoling Lin, Meilin Wang, Carly A Conran, Richard J Fantus, Ning Zhang, Shenghua Liu, Brian T Helfand, S Lilly Zheng, William B Isaacs, Qiang Ding, Zhoujun Shen, Jianfeng Xu
OBJECTIVES: Germline DNA repair gene mutations in bladder cancer (BCa) are poorly characterized. We therefore sought to perform a systematic evaluation of whether these mutations are associated with increased risk of BCa and aggressive disease. MATERIALS AND METHODS: Germline DNA from 98 BCa patients was analyzed for 54 DNA repair genes using a customized targeted sequencing panel. Population control data were obtained from the public databases Exome Aggregation Consortium database (ExAC) and Genome Aggregation Database (gnomAD)...
May 4, 2018: BJU International
https://www.readbyqxmd.com/read/29713629/helminths-and-cancers-from-the-evolutionary-perspective
#7
REVIEW
Larissa L S Scholte, Marcelo A Pascoal-Xavier, Laila A Nahum
Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes ( Schistosoma haematobium, Schistosoma japonicum , and Schistosoma mansoni ) and liver flukes ( Clonorchis sinensis and Opisthorchis viverrini ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29699519/comprehensive-gene-expression-analysis-of-canine-invasive-urothelial-bladder-carcinoma-by-rna-seq
#8
Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Naoaki Matsuki
BACKGROUND: Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is necessary to improve our understanding of progression, diagnosis, and treatment of iUC. Companion canines are a preferred animal model of iUC due to spontaneous tumor development and similarity to human disease in terms of histopathology, metastatic behavior, and treatment response...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29682192/-atm-rb1-mutations-predict-shorter-overall-survival-in-urothelial-cancer
#9
Ming Yin, Petros Grivas, Hamid Emamekhoo, Prateek Mendiratta, Siraj Ali, JoAnn Hsu, Monali Vasekar, Joseph J Drabick, Sumanta Pal, Monika Joshi
Background: Mutations of DNA repair genes, e.g. ATM/RB1 , are frequently found in urothelial cancer (UC) and have been associated with better response to cisplatin-based chemotherapy. Further external validation of the prognostic value of ATM/RB1 mutations in UC can inform clinical decision making and trial designs. Results: In the discovery dataset, ATM/RB1 mutations were present in 24% of patients and were associated with shorter OS (adjusted HR 2.67, 95% CI, 1...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29673906/interest-of-next-generation-sequencing-in-bcg-treated-high-risk-bladder-cancer
#10
C Jungels, N Martinez Chanza, S Albisinni, M Mercier, N d'Haene, S Rorive, T Roumeguère
OBJECTIVES: There are only few predictive factors for response of non-musculo-invasive bladder cancer (NMIBC) to Bacillus Calmette-Guérin (BCG) therapy. Our study analyzed the results of the sequencing of new generation (NGS) targeted on 50 genes of oncological interest obtained on bladder resection parts in high-risk NMIBC patients treated with BCG, to describe this population from a molecular point of view and try to correlate these results in patients who present or not recurrence after BCG...
April 16, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29672836/pathogenic-and-targetable-genetic-alterations-in-70-urachal-adenocarcinomas
#11
Henning Reis, Kristan E van der Vos, Christian Niedworok, Thomas Herold, Orsolya Módos, Attila Szendrői, Thomas Hager, Marc Ingenwerth, Daniël J Vis, Mark A Behrendt, Jeroen de Jong, Michiel S van der Heijden, Benoit Peyronnet, Romain Mathieu, Marcel Wiesweg, Jason Ablat, Krzysztof Okon, Yuri Tolkach, David Keresztes, Nikolett Nagy, Felix Bremmer, Nadine T Gaisa, Piotr Chlosta, Joerg Kriegsmann, Ilona Kovalszky, József Timar, Glen Kristiansen, Heinz-Joachim Radzun, Ruth Knüchel, Martin Schuler, Peter Black, Herbert Rübben, Boris Hadaschik, Kurt Werner Schmid, Bas W G van Rhijn, Péter Nyirády, Tibor Szarvas
Urachal cancer (UrC) is a rare but aggressive malignancy often diagnosed in advanced stages requiring systemic treatment. Although cytotoxic chemotherapy is of limited effectiveness, prospective clinical studies can hardly be conducted. Targeted therapeutic treatment approaches and potentially immunotherapy based on a biological rationale may provide an alternative strategy. We therefore subjected 70 urachal adenocarcinomas to targeted next-generation sequencing, conducted in situ and immunohistochemical analyses (including PD-L1 and DNA mismatch repair proteins (MMR)) and evaluated the microsatellite instability (MSI) status...
April 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29658966/methylation-in-the-promoter-regions-of-wt1-nkx6-1-and-dbc1-genes-in-cervical-cancer-tissues-of-uygur-women-in-xinjiang
#12
Dan Wu, Jinli Zhang, Peiwen Fan, Hongtao Li, Dongmei Li, Huan Pan, Hongchang He, Xianxian Ren, Zhenzhen Pan, Renfu Shao, Zemin Pan
This study aimed to explore: 1) DNA methylation in the promoter regions of Wilms tumor gene 1 (WT1), NK6 transcription factor related locus 1 gene (NKX6-1) and Deleted in bladder cancer 1 (DBC1) gene in cervical cancer tissues of Uygur women in Xinjiang, and 2) the correlation of gene methylation with the infection of HPV16/18 viruses. We detected HPV16/18 infection in 43 normal cervical tissues, 30 cervical intraepithelial neoplasia lesions (CIN) and 48 cervical cancer tissues with polymerase chain reaction (PCR) method...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29655784/aristolochic-acid-i-interferes-with-the-expression-of-blcap-tumor-suppressor-gene-in-human-cells
#13
Ying-Tzu Huang, Ting-Shuan Wu, Chuan-Chen Lu, Feng-Yih Yu, Biing-Hui Liu
Aristolochic acid I (AAI) is a phytocompound that is linked to the progressive renal disease and development of human urothelial carcinoma. The bladder cancer-associated protein (BLCAP) gene exhibits a tumor suppressor function in various tumors, including bladder carcinoma. This study evaluated the effect of AAI on BLCAP expression and its associated mechanism in human cells. Administering AAI to human embryonic kidney cells (HEK293), human proximal tubule epithelial cells (HK-2) and urinary bladder cancer cells (HT-1376) significantly reduced the expression of BLCAP mRNA and protein...
July 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29602637/importin-11-overexpression-promotes-the-migration-invasion-and-progression-of-bladder-cancer-associated-with-the-deregulation-of-cdkn1a-and-thbs1
#14
Junjie Zhao, Lei Shi, Shuxiong Zeng, Chong Ma, Weidong Xu, Zhensheng Zhang, Qingzuo Liu, Peng Zhang, Yinghao Sun, Chuanliang Xu
OBJECTIVES: We recently determined that a novel oncogene, IPO11 from 5q12, participates in bladder cancer (BCa) progression. However, the biological function of IPO11 and the molecular mechanisms through which it contributes to BCa progression remain unclear. The aim of this study was to investigate the role of IPO11 in BCa aggressiveness and elucidate the molecular mechanisms underlying its effects in BCa. MATERIALS AND METHODS: The mRNA expression levels of IPO11 in BIU-87, RT4, UMUC3, EJ, 5637, T24, J82, and HT-1376 cell lines were determined using quantitative real-time polymerase chain reaction...
March 27, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29573965/the-evolution-of-bladder-cancer-genomics-what-have-we-learned-and-how-can-we-use-it
#15
REVIEW
François Audenet, Kyrollis Attalla, John P Sfakianos
BACKGROUND: With advancements in molecular biology techniques, great progress has been made in the understanding of urothelial carcinoma pathogenesis. OBJECTIVE: To examine the historic description of molecular alterations in bladder cancer and their evolution towards our current comprehension of the biology of the disease. RESULTS: Historically, a two-pathway model was described from histological and cytogenetic studies: low-grade papillary non-muscle invasive bladder cancers (NMIBC) were described to arise from epithelial hyperplasia with loss of chromosome 9 as an early event, whereas muscle-invasive bladder cancers (MIBC) were considered to develop from dysplasia, associated with genetic instability...
March 21, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29557778/non-invasive-detection-of-urothelial-cancer-through-the-analysis-of-driver-gene-mutations-and-aneuploidy
#16
Simeon U Springer, Chung-Hsin Chen, Maria Del Carmen Rodriguez Pena, Lu Li, Christopher Douville, Yuxuan Wang, Joshua David Cohen, Diana Taheri, Natalie Silliman, Joy Schaefer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Bahman Afsari, Aline C Tregnago, Stephania M Bezerra, Christopher VandenBussche, Kazutoshi Fujita, Dilek Ertoy, Isabela W Cunha, Lijia Yu, Trinity J Bivalacqua, Arthur P Grollman, Luis A Diaz, Rachel Karchin, Ludmila Danilova, Chao-Yuan Huang, Chia-Tung Shun, Robert J Turesky, Byeong Hwa Yun, Thomas A Rosenquist, Yeong-Shiau Pu, Ralph H Hruban, Cristian Tomasetti, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Kathleen G Dickman, George J Netto
Current non-invasive approaches for detection of urothelial cancers are suboptimal. We developed a test to detect urothelial neoplasms using DNA recovered from cells shed into urine. UroSEEK incorporates massive parallel sequencing assays for mutations in 11 genes and copy number changes on 39 chromosome arms. In 570 patients at risk for bladder cancer (BC), UroSEEK was positive in 83% of those who developed BC. Combined with cytology, UroSEEK detected 95% of patients who developed BC. Of 56 patients with upper tract urothelial cancer, 75% tested positive by UroSEEK, including 79% of those with non-invasive tumors...
March 20, 2018: ELife
https://www.readbyqxmd.com/read/29544183/functional-genomics-profiling-of-bladder-urothelial-carcinoma-micrornaome-as-a-potential-biomarker
#17
Wei Tse Li, Hao Zheng, Vincent Nguyen, Jessica Wang-Rodriguez, Weg M Ongkeko
Though bladder urothelial carcinoma is the most common form of bladder cancer, advances in its diagnosis and treatment have been modest in the past few decades. To evaluate miRNAs as putative disease markers for bladder urothelial carcinoma, this study develops a process to identify dysregulated miRNAs in cancer patients and potentially stratify patients based on the association of their microRNAome phenotype to genomic alterations. Using RNA sequencing data for 409 patients from the Cancer Genome Atlas, we examined miRNA differential expression between cancer and normal tissues and associated differentially expressed miRNAs with patient survival and clinical variables...
April 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29540855/dual-strands-of-the-mir-223-duplex-mir-223-5p-and-mir-223-3p-inhibit-cancer-cell-aggressiveness-targeted-genes-are-involved-in-bladder-cancer-pathogenesis
#18
Sho Sugawara, Yasutaka Yamada, Takayuki Arai, Atsushi Okato, Tetsuya Idichi, Mayuko Kato, Keiichi Koshizuka, Tomohiko Ichikawa, Naohiko Seki
Analyses of microRNA (miRNA) expression signatures obtained by RNA sequencing revealed that some passenger miRNAs (miR-144-5p, miR-145-3p, miR-149-3p, miR-150-3p, and miR-199a-3p) acted as anti-tumor miRNAs in several types of cancer cells. The involvement of passenger strands in the pathogenesis of human cancer is a novel concept. Based on the miRNA signature of bladder cancer (BC) obtained by RNA sequencing, we focused on both strands of the miR-223-duplex (miR-223-5p and miR-223-3p) and investigated their functional significance in BC cells...
May 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29538042/the-evolving-genomic-landscape-in-urothelial-cancer
#19
Lara Kujtan, Arif Hussain, Janakiraman Subramanian, Ashiq Masood
PURPOSE OF REVIEW: Recent advances in next-generation sequencing have allowed for detailed molecular analysis of urothelial carcinomas, with potentially significant clinical implications for personalized treatment. Our objective in this review is to highlight studies from the past year that have furthered the understanding of urothelial cancer genomics. RECENT FINDINGS: Recent studies by The Cancer Genome Atlas consortium further characterized urothelial carcinomas via molecular subtyping, and a schema was proposed to match each subtype with potential therapeutic implications...
May 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29535424/comprehensive-genomic-profiling-of-neuroendocrine-bladder-cancer-pinpoints-molecular-origin-and-potential-therapeutics
#20
Peiye Shen, Ying Jing, Ruiyun Zhang, Mei-Chun Cai, Pengfei Ma, Haige Chen, Guanglei Zhuang
Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and signatures of neuroendocrine bladder cancer strikingly resembled those in conventional urothelial carcinoma, along with typically mixed histologies, supporting a common cellular origin...
March 14, 2018: Oncogene
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