Julien D Schulberg, Emily K Wright, Bronte A Holt, Amy L Hamilton, Tom R Sutherland, Alyson L Ross, Sara Vogrin, Ashley M Miller, William C Connell, Mark Lust, Nik S Ding, Gregory T Moore, Sally J Bell, Edward Shelton, Britt Christensen, Peter De Cruz, Yuwei J Rong, Michael A Kamm
BACKGROUND: Strictures are the most common structural complication of Crohn's disease. Surgery and endoscopic balloon dilation are the main treatments; drug therapy has been considered contraindicated. Given that most strictures have an inflammatory component, we aimed to find out whether strictures are responsive to drug treatment and whether intensive drug therapy is more effective than standard drug therapy. METHODS: This open-label, single-centre, randomised controlled trial was performed in one specialist inflammatory bowel disease centre in Australia...
April 2022: Lancet. Gastroenterology & Hepatology