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traditional chinese medicine principles

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https://www.readbyqxmd.com/read/29321678/systems-pharmacology-analysis-of-synergy-of-tcm-an-example-using-saffron-formula
#1
Jianling Liu, Jingjing Liu, Fengxia Shen, Zonghui Qin, Meng Jiang, Jinglin Zhu, Zhenzhong Wang, Jun Zhou, Yingxue Fu, Xuetong Chen, Chao Huang, Wei Xiao, Chunli Zheng, Yonghua Wang
Traditional Chinese medicine (TCM) follows the principle of formulae, in which the pharmacological activity of a single herb can be enhanced or potentiated by addition of other herbs. Nevertheless, the involved synergy mechanisms in formulae remain unknown. Here, a systems-based method is proposed and applied to three representative Chinese medicines in compound saffron formula (CSF): two animal spices (Moschus, Beaver Castoreum), and one herb Crocus sativus which exert synergistic effects for cardiovascular diseases (CVDs)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29248451/features-and-outcomes-of-drugs-for-combination-therapy-as-multi-targets-strategy-to-combat-alzheimer-s-disease
#2
REVIEW
Atish Kumar Sahoo, Jagnehswar Dandapat, Umesh Chandra Dash, Satish Kanhar
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD), a deleterious neurodegenerative disorder that impairs memory, cognitive functions and may lead to dementia in late stage of life. The pathogenic cause of AD remains incompletely understood and FDA approved drugs are partial inhibitors rather than curative. Most of drugs are synthetic or natural products as galanthamine is an alkaloid obtained from Galanthus spp. Huperzine A, an alkaloid found in Huperzia spp., gingkolides a diterpenoids from Gingko biloba and many ethnobotanicals like Withania somnifera (L...
December 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29235278/-guideline-principle-and-technical-requirement-for-preparing-traditional-chinese-medicine-reference-drug
#3
Li-Xing Nie, Zhong Dai, Shuang-Cheng Ma
Traditional Chinese medicine (TCM) reference drug is a new form of TCM standard reference substance. The purpose of this guideline is to guide the establishment of the reference drug and standardize its investigation and application in national drug standards. Definition of TCM reference drug was specified and relating guideline and technical requirement were introduced in this paper. Its application in quality control of TCM was analyzed and the developing train was proposed. There is a wide prospect for the application of reference drug in quality control of TCM...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29231555/-brief-discussion-on-shidong-diseases-and-suosheng-diseases-in-miraculous-pivot-and-reference-to-differentiate-them
#4
Bingyan Cao
According to Miraculous Pivot:meridian, the indications of twelve meridians were divided into two parts, the "shidong" diseases and "suosheng" diseases. Traditional Chinese medicine practitioners of later generation provided several assumptions to differentiate them, but a general conclusion was still not drawn. In this paper, the opinions of previous researches were summarized; based on this, the viewpoints of each opinion were reviewed, and the authors' opinion on method to differentiate "shidong" diseases and "suosheng" disease was proposed...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29226353/biotransformation-and-metabolic-profile-of-xian-ling-gu-bao-capsule-a-traditional-chinese-medicine-prescription-with-rat-intestinal-microflora-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry-analysis
#5
Meng-Xue Gao, Xi-Yang Tang, Feng-Xiang Zhang, Zhi-Hong Yao, Xin-Sheng Yao, Yi Dai
Xian-Ling-Gu-Bao capsule (XLGB), a well-known traditional Chinese medicine prescription (TCMP), has been used for prevention and treatment of osteoporosis. The safety and efficacy of XLGB have been confirmed based on the principle of evidence-based medicine (EBM). XLGB is usually administered orally, after which its multi-components are brought into contacted with intestinal microflora in the alimentary tract and biotransformed. However, investigations on the comprehensive metabolic profile of XLGB are absent...
December 11, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29192435/-discussion-on-scientific-problems-in-standard-decoction-of-traditional-chinese-medicine
#6
Shui-Han Zhang, Xue-Juan Liang, Hao Liu, Dan Wan, Toda Koin, Lin Chen, Rong-Rong Zhou, Lu-Qi Huang
Based on the reviewing of development and disadvantages of Chinese medicine formula granules, the concept of standard decoction of traditional Chinese medicine was proposed in this study, and it was used as the standard mode of Chinese medicine formula granules to standardize the production process and quality standards of formula granules. The standard was unified according to the principles of "standardization of medicinal materials, standardization of process, intellectualization of production, standardization of quality, normalization of packaging, and informatization of storage"; and consistency evaluation was carried out by the analysis of chemical components, pharmacological activities and clinical efficacy of the standardized decoction and the traditional decoction, interpreting the scientific questions to ensure the stability and uniformity of Chinese medicine formula granule as well as the safety and effectiveness of its clinical application...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29129604/simultaneous-determination-of-nine-kinds-of-dominating-bile-acids-in-various-snake-bile-by-ultrahigh-performance-liquid-chromatography-with-triple-quadrupole-linear-iontrap-mass-spectrometry
#7
Jie Zhang, Yeqin Fan, Yajun Gong, Xiaoyong Chen, Luosheng Wan, Chenggao Zhou, Jiewen Zhou, Shuangcheng Ma, Feng Wei, Jiachun Chen, Jing Nie
Snake bile is one of the most expensive traditional Chinese medicines (TCMs). However, due to the complicated constitutes of snake bile and the poor ultraviolet absorbance of some trace bile acids (BAs), effective analysis methods for snake bile acids were still unavailable, making it difficult to solve adulteration problems. In present study, ultrahigh-performance liquid chromatography with triple quadrupole linear ion trap mass spectrometry (UHPLC-QqQ-MS/MS) was applied to conduct a quantitative analysis on snake BAs...
November 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29082713/-research-and-development-strategies-in-classical-herbal-formulae
#8
Chang Chen, Jin-Tang Cheng, An Liu
As an outstanding representative of traditional Chinese medicine prescription, classical herbal formulae are the essence of traditional Chinese medicine great treasure. To support the development of classical herbal formulae, the state and relevant administrative departments have successively promulgated the relevant encouraged policies.But some key issues of classic herbal formulae in the development process have not reached a unified consensus and standard, and these problems were discussed in depth here...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29076119/identification-of-potential-biomarkers-from-aconitum-carmichaelii-a-traditional-chinese-medicine-using-a-metabolomic-approach
#9
Dake Zhao, Yana Shi, Xinyan Zhu, Li Liu, Pengzhang Ji, Chunlin Long, Yong Shen, Edward J Kennelly
Despite their well-known toxicity, Aconitum species are important traditional medicines worldwide. Aconitum carmichaelii, known in Chinese as (fuzi), is an officially recognized traditional Chinese medicine with characteristic analgesic and anti-inflammatory activities, whose principal pharmacological ingredients are considered as aconitine-type diterpene alkaloids. Notwithstanding the long-recorded use of A. carmichaelii in traditional Chinese medicine, no single-entity aconitum alkaloid drug has been developed for clinical use...
October 26, 2017: Planta Medica
https://www.readbyqxmd.com/read/29072001/-randomized-controlled-clinical-trials-of-eye-acupuncture-therapy-for-patients-with-post-stroke-insomnia
#10
Lu-Yang Liu, Peng-Qin Wang
OBJECTIVE: To observe the therapeutic effect of eye-acupuncture therapy for post-stroke insomnia. METHODS: Sixty patients (45-70 years in age) with post-stroke insomnia were randomized into eye-acupuncture group and routine acupuncture (body acupuncture) group (30 cases in each). Patients of the eye-acupuncture group were treated by acupuncture stimulation of bilateral Shangjiao (Upper-energizer) and Xin (Heart) regions and those of the routine acupuncture group treated by acupuncture stimulation of Baihui (GV 20), Sishencong (EX-HN 1), Anmian (EX-HN 16), etc...
February 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29057475/erding-formula-in-hyperuricaemia-treatment-unfolding-traditional-chinese-herbal-compatibility-using-modern-pharmaceutical-approaches
#11
Jieyu Zuo, Hongming He, Zhengyun Zuo, Nádia Bou-Chacra, Raimar Löbenberg
OBJECTIVES: Traditional Chinese herbal formulas are difficult to be understood because of complex compositions and specific therapeutic principles. To better understand herbal compatibility in Traditional Chinese medicine (TCM), this study was conducted to investigate the effects of a Chinese pharmacopoeia-listed formula, Erding Formula (EF) and its constituent herbs for a new indication, hyperuricaemia. METHODS: A hypoxanthine and potassium oxonate-induced hyperuricemic mouse model, a xylene-induced inflammatory mouse model and an acetic acid-induced pain model were used to test the effects of EF and its constituent herbs...
October 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29027440/-analysis-on-composition-principles-of-tibetan-medicine-containing-terminalia-chebula-by-data-mining
#12
Wen-Juan Yang, Yong-Zhong Zeweng, Yi Zhang, Zang-Jia Geng, Jia Nie
This study using traditional Chinese medicine inheritance support software(TCMISS) to analyze the prescription rules of Tibetan medicine containing Terminalia chebula in the Encyclopedia of Chinese Medicine-Tibetan Medicine, Tibetan Medicine Composition Preparation of Modern Research and Clinical Application and Common Interpretation of Tibetan Medicine and so on. TCMISS(V2.5) was used to build a prescription database of Tibetan medicine containing T. chebula.The software statistical statement module, association rules and improved mutual information method and other data mining technologies were adopted to analyze the common herbs, combination rules and core combination of prescriptions containing T...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28994522/-moderation-integrated-balance-presupposition-of-chinese-medicine-compound-and-pharmacological-problems-in-traditional-chinese-drug-research
#13
Jun-Ning Zhao
The moderation-integrated-balance presupposition (MIBP) of Chinese medicine compound was first proposed in this paper based on the review of function characteristics and action principles of Chinese medicine compound. Furthermore, the pharmacological problems of traditional Chinese drug research were discussed in details. The results were of important value in accelerating the transformation of traditional Chinese medicine compound, and constructing the new drug innovation and review system for traditional Chinese medicine...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28974750/discrimination-of-geographical-origin-of-cultivated-polygala-tenuifolia-based-on-multi-element-fingerprinting-by-inductively-coupled-plasma-mass-spectrometry
#14
Yunsheng Zhao, Xiaofang Ma, Lingling Fan, Fuying Mao, Hongling Tian, Rui Xu, Zhe Cao, Xinhui Zhang, Xueyan Fu, Hong Sui
Inorganic elements are important components of medicinal herbs, and provide valuable experimental evidence for the quality evaluation and control of traditional Chinese medicine (TCM). In this study, to investigate the relationship between the inorganic elemental fingerprint and geographical origin identification of cultivated Polygala tenuifolia, 41 elemental fingerprints of P. tenuifolia from four major polygala-producing regions (Shanxi, Hebei, Henan, and Shaanxi) were evaluated to determine the importance of inorganic elements to cultivated P...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28952243/-application-of-immunoassay-in-fast-quality-evaluation-of-traditional-chinese-medicine
#15
REVIEW
Bo Zhang, Tie-Gui Nan, Qing Sun, Hong-Mei Liu, Feng-Wei Ding, Ying Wang
The quality evaluation of traditional Chinese medicine can be divided into two aspects, effectiveness and safety. The existing methods for evaluating the quality of traditional Chinese medicine(TCM) are mostly based on the testing instruments, which can not meet the practical needs of simple, rapid and on-site in production and life. Immunoassay, characterized by simple, rapid, sensitive, specific, low-cost and high-throughput, is widely used in the fields of clinical diagnosis, environmental pollution monitoring, food safety testing, and other fields...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28933119/-research-on-rat-models-of-acute-liver-injury-with-syndrome-of-liver-depression-and-spleen-deficiency
#16
Na-Na Huang, Xiao-Qian Sun, Qian Yang, Xiao-Yu Li, Rong Sun
This paper aimed to establish animal models which are suitable for the activity found, efficacy evaluation of herbs resistant to acute liver injury with syndrome of liver depression and spleen deficiency and new drug research and development based on corresponding of formula and syndrome. The symptoms that are suitable for evaluating the rat models of acute liver injury with syndrome of liver depression and spleen deficiency were extracted according to the evolution rule of the etiology and pathogenesis in traditional Chinese medicine and the modern pathological mechanism...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28933115/-rancidness-of-armeniacae-semen-amarum-involving-bianzhuang-lunzhi
#17
Jian-Ting Gong, Li-Ying Zhao, Bauer Rudolf, Wen-Juan Mi, Yang Li, Jia-Hui Li, Zhi-Yu Ren, Dong Xu, Ting Zhao, Yong-Hong Yan
This article aims to compare the qualities of Armeniacae Semen Amarum before and after rancidness, in order to study the rancidness of Armeniacae Semen Amarum. In the experiment, content of fatty oil, acid value and peroxide value were determined before and after rancidness,respectively. Meanwhile, HPLC, GC-MS were utilized to analyze laetrile and fatty acid components. Besides, colorimeter and e-nose were introduced to quantify and compare "color and odor". A correlation analysis was conducted on the above results...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929694/-methodological-quality-evaluation-of-randomized-controlled-trials-for-traditional-chinese-medicines-for-treatment-of-sub-health
#18
Jun Zhao, Xing Liao, Hui Zhao, Zhi-Geng Li, Nan-Yue Wang, Li-Min Wang
To evaluate the methodological quality of the randomized controlled trials(RCTs) for traditional Chinese medicines for treatment of sub-health, in order to provide a scientific basis for the improvement of clinical trials and systematic review. Such databases as CNKI, CBM, VIP, Wanfang, EMbase, Medline, Clinical Trials, Web of Science and Cochrane Library were searched for RCTS for traditional Chinese medicines for treatment of sub-health between the time of establishment and February 29, 2016. Cochrane Handbook 5...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929676/-understanding-and-development-strategy-of-health-food-containing-chinese-materia-medica
#19
REVIEW
Lin-Yuan Wang, Jian-Jun Zhang, Chun Wang, Jing-Xia Wang, Ying-Li Zhu, Jia Wang, Xue-Min Gao
Health food containing Chinese materia medica (CMM) conforms to the development demands of the age of big health and the theory of preventive treatment. In the view of health care and improvement of resisting diseases, it plays an important role in the market. It is very necessary to have further study and discussion on health food containing CMM. First of all, by comparing, analyzing and summarizing, the health food containing CMM could be defined as the health food which is qualified in security and functionality evaluation, with the traditional Chinese medicines(TCM) within TCM standards as the main raw materials, and the formulation-composition is based on the theory of TCM...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925140/-near-infrared-spectroscopy-based-process-trajectory-technology-and-its-application-in-monitoring-and-controlling-of-traditional-chinese-medicine-manufacturing-process
#20
Wen-Long Li, Hai-Bin Qu
In this paper, the principle of NIRS (near infrared spectroscopy)-based process trajectory technology was introduced.The main steps of the technique include:① in-line collection of the processes spectra of different technics; ② unfolding of the 3-D process spectra;③ determination of the process trajectories and their normal limits;④ monitoring of the new batches with the established MSPC (multivariate statistical process control) models.Applications of the technology in the chemical and biological medicines were reviewed briefly...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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