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https://www.readbyqxmd.com/read/28363525/protective-effect-of-a-phenolic-extract-containing-indoline-amides-from-portulaca-oleracea-against-cognitive-impairment-in-senescent-mice-induced-by-large-dose-of-d-galactose-nano2
#1
Peipei Wang, Hongxiang Sun, Dianyu Liu, Zezhao Jiao, Su Yue, Xiuquan He, Wen Xia, Jianbo Ji, Lan Xiang
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea L. is a potherb and also a widely used traditional Chinese medicine. In accordance with its nickname "longevity vegetable", pharmacological study demonstrated that this plant possessed antioxidant, anti-aging, and cognition-improvement function. Active principles pertaining to these functions of P. oleracea need to be elucidated. AIM OF THE STUDY: The present study evaluated the effect of a phenolic extract (PAAs) from P...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28352348/gambogic-acid-potentiates-the-chemosensitivity-of-colorectal-cancer-cells-to-5-fluorouracil-by-inhibiting-proliferation-and-inducing-apoptosis
#2
Jianchang Wei, Ping Yang, Wanglin Li, Feng He, Shanqi Zeng, Tong Zhang, Junbin Zhong, Di Huang, Zhuanpeng Chen, Chengxing Wang, Huacui Chen, He Hu, Jie Cao
Chemotherapy using 5-fluorouracil (5-FU) for colorectal cancer (CRC) has low specificity and response rates, leading to severe side effects. Gambogic acid (GA), a traditional Chinese medicine, has multi-targeted anticancer effects, including growth inhibition and apoptosis induction. However, it is unclear whether a combination of 5-FU and GA has synergistic anticancer effects in CRC cells. In this study, SW480 and HCT116 human CRC cells and human intestinal epithelial cells (IECs) were treated with different concentrations of 5-FU, GA or 5-FU+GA...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28271655/use-of-electroacupuncture-and-transcutaneous-electrical-acupoint-stimulation-in-reproductive-medicine-a-group-consensus
#3
Fan Qu, Rong Li, Wei Sun, Ge Lin, Rong Zhang, Jing Yang, Li Tian, Guo-Gang Xing, Hui Jiang, Fei Gong, Xiao-Yan Liang, Yan Meng, Jia-Yin Liu, Li-Ying Zhou, Shu-Yu Wang, Yan Wu, Yi-Jing He, Jia-Yu Ye, Song-Ping Han, Ji-Sheng Han
With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS), become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility. This present paper describes how to select acupoints for the treatment of infertility from the view of theories of traditional Chinese medicine and how to determine critical parameters of electric pulses of EA/TEAS based on results from animal and clinical studies...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28257573/toward-understanding-the-cold-hot-and-neutral-nature-of-chinese-medicines-using-in-silico-mode-of-action-analysis
#4
Xianjun Fu, Lewis H Mervin, Xuebo Li, Huayun Yu, Jiaoyang Li, Siti Zuraidah Mohamad Zobir, Azedine Zoufir, Yang Zhou, Yongmei Song, Zhenguo Wang, Andreas Bender
One important, however, poorly understood, concept of Traditional Chinese Medicine (TCM) is that of hot, cold, and neutral nature of its bioactive principles. To advance the field, in this study, we analyzed compound-nature pairs from TCM on a large scale (>23 000 structures) via chemical space visualizations to understand its physicochemical domain and in silico target prediction to understand differences related to their modes-of-action (MoA) against proteins. We found that overall TCM natures spread into different subclusters with specific molecular patterns, as opposed to forming coherent global groups...
March 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28254105/a-single-case-of-tourette-s-syndrome-treated-with-traditional-chinese-medicine
#5
Min-Hwa Lee
The objective of this case study was to investigate the effectiveness of Chinese medicine in treating Tourette's syndrome. Tourette's syndrome is a childhood- onset disorder that is characterized by sudden, involuntary movements or tics. The participant in this study was a 33-year-old male who had been diagnosed with Tourette's syndrome at the age of 9 years. His major complaints included facial tics, shoulder shrugging, and clearing the throat. Using a combination of acupuncture, herbs, Gua-Sha, and lifestyle changes once a week for 35 treatments, all the symptoms were reduced by 70%, as reported by the patient...
January 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28137413/achyranthes-bidentate-saponins-protect-rat-articular-chondrocytes-against-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in%C3%A2-vitro
#6
Xian-Xiang Xu, Xiao-Hong Zhang, Yong Diao, Yu-Xiang Huang
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bioactive principles. In the present study, protective effects of A. bidentata saponins (ABS) on inflammation and apoptosis in interleukine-1β (IL-1β)-induced chondrocytes were investigated. Rat chondrocytes were pretreated with ABS at 3 μg/mL, 10 μg/mL, and 30 μg/mL, and subsequently stimulated with IL-1β (10 ng/mL)...
February 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28088255/a-review-on-different-english-versions-of-an-ancient-classic-of-chinese-medicine-huang-di-nei-jing
#7
REVIEW
Xiao Ye, Min-Hua Dong
Huang Di Nei Jing (Nei Jing), one of the most important classical texts of traditional Chinese medicine, is the foundation upon which today's Chinese medicine principles are built. This seminal ancient classic has been translated into English many times by different scholars worldwide. The authors have found thirteen English versions, each of which has its own distinctive features. By reviewing different versions and research achievements of the English translation, the authors try to summarize the translation style, purpose, content and other features of each version, and point out each translation's weaknesses, strengths, or significance...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28057058/efficacy-and-safety-of-lian-ju-gan-mao-capsules-for-treating-the-common-cold-with-wind-heat-syndrome-study-protocol-for-a-randomized-controlled-trial
#8
Shengjun Wang, Hongli Jiang, Qin Yu, Bin She, Bing Mao
BACKGROUND: The common cold is a common and frequent respiratory disease mainly caused by viral infection of the upper respiratory tract. Chinese herbal medicine has been increasingly prescribed to treat the common cold; however, there is a lack of evidence to support the wide utility of this regimen. This protocol describes an ongoing phase II randomized controlled clinical trial, based on the theory of traditional Chinese medicine (TCM), with the objective of evaluating the efficacy and safety of Lian-Ju-Gan-Mao capsules (LJGMC), a Chinese patent medicine, compared with placebo in patients suffering from the common cold with wind-heat syndrome (CCWHS)...
January 5, 2017: Trials
https://www.readbyqxmd.com/read/27968847/bushenjianpi-formula-combined-with-entecavir-for-hbeag-negative-chronic-hepatitis-b-patients-a-multicentre-randomised-double-blind-placebo-controlled-trial
#9
Yue-Qiu Gao, Xin Zhang, Man Li, Zhen-Hua Zhou, Xue-Hua Sun, Xiao-Jun Zhu, Shu-Gen Jin
BACKGROUND: The treatment combination of traditional Chinese medicine with western medicine results in significant decrease of serum hepatitis B virus (HBV) DNA and increase of HBeAg loss in patients with HBeAg-positive chronic hepatitis B (CHB) without any serious adverse events. We aimed to assess whether the Bushenjianpi Formula combined with entecavir could increase the HBsAg loss rate in patients with HBeAg-negative CHB. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, we recruited patients with HBeAg-negative CHB from ten third-level grade-A hospital of Traditional Chinese Medicine...
October 2016: Lancet
https://www.readbyqxmd.com/read/27965050/the-optimal-dose-of-arsenic-trioxide-induced-opposite-efficacy-in-autophagy-between-k562-cells-and-their-initiating-cells-to-eradicate-human-myelogenous-leukemia
#10
Zhenzhen Guo, Mingjing Meng, Shengnan Geng, Zhenhua Du, Yaqiu Zheng, Jingjing Yao, Zibo Li, Guang Han, Haihong Lin, Gangjun Du
ETHNOPHARMACOLOGICAL RELEVANCE: Arsenic trioxide (As2O3), a main component of arsenolite which is a common traditional Chinese medicine (TCM) wildly used as a therapeutic agent for more than 2400 years in china, has been accepted as a standard treatment for the patients with acute promyelocytic leukemia (APL) based on the principle in TCM of "using a poison to fight against other poisons or malignancy illnesses". However, it remains unknown that which mechanism is actually responsible for the therapeutic effects against these blood malignancies...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27956918/the-applications-and-features-of-liquid-chromatography-mass-spectrometry-in-the-analysis-of-traditional-chinese-medicine
#11
REVIEW
Bingyao Pang, Ying Zhu, Longqing Lu, Fangbing Gu, Hailong Chen
With increasingly improved separation of complex samples and detection of unknown material capabilities, liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in traditional Chinese medicine (TCM) research. This article describes the principles of liquid chromatography (LC) and mass spectrometry (MS) and their advantages and disadvantages in qualitative and quantitative analysis of TCM. We retrieved research literatures about the application of LC-MS in TCM published during the past five years at home and abroad...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27912962/the-influence-of-traditional-chinese-medicine-constitutions-on-the-potential-repair-capacity-after-osteonecrosis-of-the-femoral-head
#12
Tong Yu, Zhennan Zhang, Limin Xie, Xun Ke, Yang Liu
OBJECTIVES: To explore the effects of traditional Chinese medicine (TCM) constitutions on repair capacity after osteonecrosis of the femoral head (ONFH). DESIGN AND SETTING: Ninety-six patients with TCM constitutions of yang-deficiency, dampness-heat and/or blood-stasis were recruited from the orthopedic outpatient clinic of the Guang'anmen Hospital of the China Academy of Chinese Medical Science. Each patient underwent computed tomography (CT) examination of the hips, and CAD software was used to estimate proximal sclerosis ratios based on the CT images...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27852126/traditional-chinese-medicine-food-therapy-and-hypertension-control-a-narrative-review-of-chinese-literature
#13
REVIEW
Ping Zou
Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27845727/ligand-fishing-a-remarkable-strategy-for-discovering-bioactive-compounds-from-complex-mixture-of-natural-products
#14
REVIEW
Rongjie Zhuo, Hao Liu, Ningning Liu, Yi Wang
Identification of active compounds from natural products is a critical and challenging task in drug discovery pipelines. Besides commonly used bio-guided screening approaches, affinity selection strategy coupled with liquid chromatography or mass spectrometry, known as ligand fishing, has been gaining increasing interest from researchers. In this review, we summarized this emerging strategy and categorized those methods as off-line or on-line mode according to their features. The separation principles of ligand fishing were introduced based on distinct analytical techniques, including biochromatography, capillary electrophoresis, ultrafiltration, equilibrium dialysis, microdialysis, and magnetic beads...
November 11, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27785941/new-development-in-traditional-chinese-medicine-symbolism-digit-therapy-as-a-special-naturopathic-treatment
#15
REVIEW
Shanyu Li, Stevenson Xutian
Traditional Chinese medicine (TCM) grew out of traditional Chinese culture. For example, the eight-diagram symbol is composed of the Yang and the Yin. According to oriental philosophy, everything in the universe has a two-sided property, namely an image (or symbol) and a number (or digit). This paper introduces the new concept and historical background of symbolism-digit therapy (SDT), which is a natural therapy for the treatment of various kinds of diseases. SDT is of TCM heritage, which can be traced back to the ancient publications such as Yi Jing, and this heritage has been incorporated into modern development and practices...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27768943/state-risk-discourse-and-the-regulatory-preservation-of-traditional-medicine-knowledge-the-case-of-acupuncture-in-ontario-canada
#16
Nadine Ijaz, Heather Boon, Linda Muzzin, Sandy Welsh
Several United Nations bodies have advised countries to actively preserve Traditional Medicine (TM) knowledge and prevent its misappropriation in regulatory structures. To help advance decision-making around this complex regulatory issue, we examine the relationship between risk discourse, epistemology and policy. This study presents a critical, postcolonial analysis of divergent risk discourses elaborated in two contrasting Ontario (Canada) government reports preceding that jurisdiction's regulation of acupuncture, the world's most widely practised TM therapy...
December 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27766596/effects-of-acupuncture-on-quality-of-life-and-pain-in-patients-with-osteoporosis-a-pilot-randomized-controlled-trial
#17
Joerg Schiller, Christoph Korallus, Matthias Bethge, Matthias Karst, Marie-Lena Schmalhofer, Christoph Gutenbrunner, Matthias Georg Fink
In this sham-controlled study, 53 patients received 10 sessions of acupuncture treatment over 5 weeks to investigate the effects of acupuncture on the pain and quality of life of patients with osteoporosis. The results showed significant favorable effects of verum acupuncture on quality of life. Both interventions showed sustained and clinically relevant effects on pain. PURPOSE: Standard analgesic treatment is associated with adverse events in patients with osteoporosis, especially elderly and/or comorbid patients...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27734592/traditional-chinese-medicine-for-schizophrenia-a-survey-of-randomized-trials
#18
REVIEW
Hongyong Deng, Clive E Adams
OBJECTIVE: To survey the reports of randomized trials of traditional Chinese medicine (TCM) interventions for schizophrenia and produce a broad overview of this type of research activity in this area. METHOD: We searched the Cochrane Schizophrenia Group's comprehensive Trials Register (January 2016), selected all relevant randomized trials, and extracted the data within each study. Finally, we sought relevant reviews on the Cochrane Library. RESULTS: We initially screened 423 articles from which we identified 378 relevant studies randomizing 35 341 participants (average study size 94, SD 60)...
March 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/27729283/locally-and-traditionally-used-ligusticum-species-a-review-of-their-phytochemistry-pharmacology-and-pharmacokinetics
#19
REVIEW
Paul Owusu Donkor, Ying Chen, Liqin Ding, Feng Qiu
ETHNOPHARMACOLOGICAL RELEVANCE: Ligusticum species (Umbelliferae) have been widely used in traditional Chinese medicine, Korean folk medicine and Native American medicine for their medicinal and nutritional value. Decoctions of the rhizomes are used in treatment and prophylaxis of migraine, anemia and cardiovascular conditions including stroke. AIM OF STUDY: This review is intended to fully compile the constituents of locally and traditionally used Ligusticum species, present their bioactivities and highlight potential leads for future drug design, and thus, provide a reference for further research and application of these species...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27704591/a-cell-based-high-throughput-protocol-to-screen-entry-inhibitors-of-highly-pathogenic-viruses-with-traditional-chinese-medicines
#20
Yong Yang, Han Cheng, Hui Yan, Peng-Zhan Wang, Rong Rong, Ying-Ying Zhang, Cheng-Bo Zhang, Rui-Kun Du, Li-Jun Rong
Emerging viruses such as Ebola virus (EBOV), Lassa virus (LASV), and avian influenza virus H5N1 (AIV) are global health concerns. Since there is very limited options (either vaccine or specific therapy) approved for humans against these viruses, there is an urgent need to develop prophylactic and therapeutic treatments. Previously we reported a high-throughput screening (HTS) protocol to identify entry inhibitors for three highly pathogenic viruses (EBOV, LASV, and AIV) using a human immunodeficiency virus-based pseudotyping platform which allows us to perform the screening in a BSL-2 facility...
May 2017: Journal of Medical Virology
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