Taizo Kimura, Kozoh Shiraishi, Aya Furusho, Sohei Ito, Saki Hirakata, Norifumi Nishida, Koichi Yoshimura, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Yasuhiro Ikeda, Takanobu Miyamoto, Takafumi Ueno, Kimikazu Hamano, Michiaki Hiroe, Kazutaka Aonuma, Masunori Matsuzaki, Tsutomu Imaizumi, Hiroki Aoki
Acute aortic dissection (AAD) is caused by the disruption of intimomedial layer of the aortic walls, which is immediately life-threatening. Although recent studies indicate the importance of proinflammatory response in pathogenesis of AAD, the mechanism to keep the destructive inflammatory response in check is unknown. Here, we report that induction of tenascin-C (TNC) is a stress-evoked protective mechanism against the acute hemodynamic and humoral stress in aorta. Periaortic application of CaCl₂ caused stiffening of abdominal aorta, which augmented the hemodynamic stress and TNC induction in suprarenal aorta by angiotensin II infusion...
2014: Scientific Reports