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preterm, preeclampsia

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https://www.readbyqxmd.com/read/29328602/aspirin-versus-placebo-in-pregnancies-at-high-risk-for-preterm-preeclampsia
#1
Kypros H Nicolaides
No abstract text is available yet for this article.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29328601/aspirin-versus-placebo-in-pregnancies-at-high-risk-for-preterm-preeclampsia
#2
Loïc Sentilhes, Elie Azria, Thomas Schmitz
No abstract text is available yet for this article.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29325073/the-women-s-health-diagnostic-gap
#3
Ann M Gronowski, Melanie L Yarbrough
Pregnancy remains a significant health risk to women in both developed and underdeveloped countries. Worldwide, 10 to 20 million women have pregnancy complications including ectopic pregnancy, preterm birth, gestational diabetes mellitus, and hypertensive states, including preeclampsia. Despite advancements in women's health research, there is a large gap in the diagnostic tools available to screen, diagnose, and monitor these conditions. Herein, we examine existing diagnostic tools, such as the human chorionic gonadotropin discriminatory zone, cervicovaginal fetal fibronectin, sFlt-1:PlGF ratio, and glucose tolerance testing...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29324603/pregnancy-associated-hypertension-and-offspring-cardiometabolic-health
#4
Madeline Murguia Rice, Mark B Landon, Michael W Varner, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George Saade, Alan M Peaceman, Sean C Blackwell
OBJECTIVE: To evaluate whether pregnancy-associated hypertension (gestational hypertension and preeclampsia) was associated with the cardiometabolic health of young offspring. METHODS: This was a prospective observational follow-up study from 2012 to 2013 of children born to women previously enrolled in a mild gestational diabetes mellitus treatment trial or nongestational diabetes mellitus observational study. At 5-10 years after birth, children were examined and fasting blood samples obtained to determine the following cardiometabolic risk factors: blood pressure (BP), high-density lipoprotein cholesterol, triglycerides, glucose, homeostatic model assessment of insulin resistance, waist circumference, and body mass index (BMI)...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29320955/therapeutic-roles-of-statins-in-gynecology-and-obstetrics-the-current-evidence
#5
Burak Zeybek, Maged Costantine, Gokhan S Kilic, Mostafa A Borahay
INTRODUCTION: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29320948/the-profiles-of-soluble-adhesion-molecules-in-the-great-obstetrical-syndromes
#6
Nikolina Docheva, Roberto Romero, Piya Chaemsaithong, Adi L Tarca, Gaurav Bhatti, Percy Pacora, Bogdan Panaitescu, Noppadol Chaiyasit, Tinnakorn Chaiworapongsa, Eli Maymon, Sonia S Hassan, Offer Erez
OBJECTIVE: The objective of this study was to determine the profiles of maternal plasma soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) fetuses, acute pyelonephritis, preterm labor with intact membranes (PTL), preterm prelabor rupture of the membranes (preterm PROM), and fetal death. MATERIALS AND METHODS: A cross-sectional study was conducted to determine maternal plasma concentrations of sE-selectin, sL-selectin, and sP-selectin as well as sICAM-1, sVCAM-1, and sPECAM-1 in patients with 1) an uncomplicated pregnancy (control, n = 100); 2) preeclampsia (n = 94); 3) SGA fetuses (in women without preeclampsia/hypertension, n = 45); 4) acute pyelonephritis (n = 25); 5) PTL (n = 53); 6) preterm PROM (n = 24); and 7) fetal death (n = 34)...
January 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29310615/avoiding-late-preterm-deliveries-to-reduce-neonatal-complications-an-11-year-cohort-study
#7
Noémie Bouchet, Angèle Gayet-Ageron, Marina Lumbreras Areta, Riccardo Erennio Pfister, Begoña Martinez de Tejada
BACKGROUND: Late preterm (LPT) newborns, defined as those born between 34 0/7 and 36 6/7 gestational weeks, have higher short- and long-term morbidity and mortality than term infants (≥37 weeks). A categorization to justify a non-spontaneous LPT delivery has been proposed to distinguish evidence-based from non-evidence-based criteria. This study aims to describe rates and temporal trends of non-spontaneous LPT neonates delivered according to evidence-based or non-evidence-based criteria and to evaluate the number of avoidable LPT deliveries, including severe neonatal morbidity rates and associated risk factors...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29305253/chronic-hypertension-first-trimester-blood-pressure-control-and-likelihood-of-severe-hypertension-preeclampsia-and-small-for-gestational-age
#8
Diane Nzelu, Dan Dumitrascu-Biris, Kypros H Nicolaides, Nikos A Kametas
BACKGROUND: There is extensive evidence that pre-pregnancy chronic hypertension is associated with high risk of development of severe hypertension and preeclampsia and birth of small for gestational age neonates. However, previous studies have not reported whether anti-hypertensive use, blood pressure control or normalization of blood pressure during early pregnancy influence the rates of these pregnancy complications. OBJECTIVE: To stratify women with pre-pregnancy chronic hypertension according to the use of antihypertensive medications and level of blood pressure control at the first hospital visit during the first-trimester of pregnancy and examine the rates of severe hypertension, preeclampsia and birth of small for gestational age neonates according to such stratification...
January 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29304810/socioeconomic-status-can-affect-pregnancy-outcomes-and-complications-even-with-a-universal-healthcare-system
#9
Min Kyoung Kim, Seung Mi Lee, Sung-Hee Bae, Hyun Joo Kim, Nam Gu Lim, Seok-Jun Yoon, Jin Yong Lee, Min-Woo Jo
BACKGROUND: Low socioeconomic status can increase the risk of adverse pregnancy outcomes, but it remains unclear whether this negative association is attributed to inadequate prenatal care. Korea has been adopting a universal healthcare system. All Korean citizens must be enrolled National Health Insurance (NHI) or be recipient of Medical Aid (MA). In addition, Korean government launched a financial support system for antenatal care for all pregnant women in 2008. Therefore, in theory, there is no financial barrier to receive prenatal cares regardless of someone's social class...
January 5, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29303121/maternal-and-obstetric-complications-among-hiv-infected-women-treated-with-highly-active-antiretroviral-treatment-at-a-regional-hospital-in-durban-south-africa
#10
H M Sebitloane, J Moodley
INTRODUCTION: HIV is the leading cause of maternal deaths in resource-poor countries. The use of highly active antiretroviral treatment (HAART) has been shown to almost eliminate vertical transmission and improve maternal health outcomes. Its effect on direct obstetric conditions has not been well documented. METHODS: We conducted a retrospective study of women who delivered at a regional hospital from April 1, 2011, to April 30, 2014. We employed a stratified random selection, where the first 50 files recorded in the birth register during each calendar month were chosen, at a ratio of one HIV uninfected for every 4 infected women...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29302809/preeclampsia-acts-differently-in-in-vitro-fertilization-versus-spontaneous-twins
#11
Rania Okby, Avi Harlev, Kira Nahum Sacks, Ruslan Sergienko, Eyal Sheiner
OBJECTIVE: To investigate risk factors and pregnancy outcome of spontaneous vs in-vitro fertilization (IVF) twins complicated with preeclampsia. STUDY DESIGN: A retrospective population-based cohort study comparing maternal and neonatal outcome in IVF vs spontaneously conceived twins was conducted. Deliveries occurred in a tertiary medical center between the years 1988 and 2010. Women who conceived after ovulation induction and those with chronic hypertension were excluded from the study...
January 4, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29301455/body-mass-index-at-11-13%C3%A2-weeks-gestation-and-pregnancy-complications-in-a-southern-chinese-population-a-retrospective-cohort-study
#12
Piya Chaemsaithong, Tak Yeung Leung, Daljit Sahota, Yvonne Kwun Yue Cheng, Wing Cheong Leung, Tsz Kin Lo, Liona Chiu Yee Poon
OBJECTIVE: To assess the association between body mass index (BMI) and adverse pregnancy outcomes. MATERIALS AND METHODS: A multicentre retrospective cohort study was conducted in three hospitals in Hong Kong including 67 248 women with singleton pregnancy at 11-13 weeks between 2010-2016. The relationship between maternal BMI and [1] miscarriage or stillbirth, [2] development of preeclampsia (PE), [3] gestational hypertension (GH), [4] development of gestational diabetes mellitus (GDM), [5] spontaneous preterm delivery (sPTD) < 34 and < 37 weeks, [6] delivery of a small for gestational age (SGA) or large for gestational age (LGA) neonate, [7] caesarean section (CS) and [8] postpartum haemorrhage (PPH) were examined after adjusting for confounding factors...
January 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29301419/antenatal-magnesium-sulfate-is-beneficial-or-harmful-in-very-preterm-and-extremely-preterm-neonates-a-new-insight
#13
Bhawan Garg
Magnesium sulfate (MgSO4) is drug of choice for both prevention of eclampsia in women with severe preeclampsia and treatment of eclampsia. Antenatal MgSO4 is now emerging as popular neuroprotective agent in preterm neonates. However, recent studies reported an association of antenatal MgSO4 with feed intolerance, necrotizing enterocolitis and spontaneous intestinal perforation in extremely preterm neonates. In this review article, we discuss both aspects of antenatal MgSO4 in preterm neonates.
January 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29298455/preterm-preeclampsia-with-severe-features-composite-maternal-and-neonatal-morbidities-associated-with-fetal-growth-restriction
#14
Olaide Ashimi Balogun, Raminder K Khanagura, Heather R Kregel, Farah H Amro, Baha M Sibai, Suneet P Chauhan
OBJECTIVE:  The objective of this study was to compare adverse pregnancy outcomes between fetuses with estimated fetal weight (EFW) < 10 to > 10% in women with preterm preeclampsia (PE) with severe features. MATERIALS AND METHODS:  All women with preterm PE with severe features and nonanomalous singletons with EFW were identified at a tertiary center. Women with oligohydramnios or absent/reversed umbilical Doppler velocimetry were excluded. Using multivariable analysis, we compared the composite maternal and neonatal morbidities (CMM and CNM) between those with appropriate for gestational age (AGA) fetal growth, defined as EFW at 10 to 90th versus those with fetal growth restriction (FGR), defined as EFW < 10th percentile for gestational age (GA)...
January 3, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29287294/outcomes-of-medically-indicated-preterm-births-differ-by-indication
#15
Michelle J Wang, Spencer G Kuper, Robin Steele, Rachel A Sievert, Alan T Tita, Lorie M Harper
OBJECTIVE:  We aim to examine whether outcomes of preterm birth (PTB) are further modified by the indication for delivery. STUDY DESIGN:  We performed a retrospective cohort study of all singletons delivered at 23 to 34 weeks from 2011 to 2014. Women were classified by their primary indication for delivery: maternal (preeclampsia) or fetal/obstetric (growth restriction, nonreassuring fetal status, and vaginal bleeding). The primary neonatal outcome was a composite of neonatal death, cord pH <7 or base excess < - 12, 5-minute Apgar ≤3, C-reactive protein during resuscitation, culture-proven sepsis, intraventricular hemorrhage, and necrotizing enterocolitis...
December 29, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29282226/maternal-and-fetal-outcomes-of-pregnancies-in-women-with-atypical-hemolytic-uremic-syndrome
#16
Martina Gaggl, Christof Aigner, Dorottya Csuka, Ágnes Szilágyi, Zoltán Prohászka, Renate Kain, Natalja Haninger, Maarten Knechtelsdorfer, Raute Sunder-Plassmann, Gere Sunder-Plassmann, Alice Schmidt
Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the alternative pathway of complement, or the proteins that regulate this pathway, and life-threatening episodes of aHUS can be provoked by pregnancy. We retrospectively and prospectively investigated 27 maternal and fetal pregnancy outcomes in 14 women with aHUS from the Vienna Thrombotic Microangiopathy Cohort. Seven pregnancies (26%) were complicated by pregnancy-associated aHUS (p-aHUS), of which three appeared to be provoked by infection, bleeding, and curettage, and three individuals were considered to have preeclampsia/HELLP syndrome before the definitive diagnosis of p-aHUS was made...
December 27, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29275882/dysfunctional-uterine-activity-in-labour-and-premature-adverse-cardiac-events-population-based-cohort-study
#17
Alyssa Kahane, Alison L Park, Joel G Ray
BACKGROUND: There exist structural and physiological commonalities between myometrial and myocardial tissue, and each can become dysfunctional, such as in the presence of cardiometabolic factors. METHODS: This population-based cohort study was comprised of 1,608,720 women with ≥ 1 singleton hospital live birth at 24-41 weeks' gestation in Ontario, from 1992 to 2016. The main exposure was prolonged first stage of labour; secondary exposure was prolonged second stage of labour...
January 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29275823/is-there-a-role-for-placental-senescence-in-the-genesis-of-obstetric-complications-and-fetal-growth-restriction
#18
REVIEW
Zakia Sultana, Kaushik Maiti, Lee Dedman, Roger Smith
The placenta ages as pregnancy advances, yet its continued function is required for a successful pregnancy outcome. Placental aging is a physiological phenomenon; however, there are some placentas that show signs of aging earlier than others. Premature placental senescence and aging are implicated in a number of adverse pregnancy outcomes, including fetal growth restriction, preeclampsia, spontaneous preterm birth, and intrauterine fetal death. Here we discuss cellular senescence, a state of terminal proliferation arrest, and how senescence is regulated...
December 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29273044/a-randomized-controlled-trial-of-exercise-during-pregnancy-on-maternal-and-neonatal-outcomes-results-from-the-pamela-study
#19
Shana Ginar da Silva, Pedro Curi Hallal, Marlos Rodrigues Domingues, Andréa Dâmaso Bertoldi, Mariângela Freitas da Silveira, Diego Bassani, Inácio Crochemore Mohnsam da Silva, Bruna Gonçalves Cordeiro da Silva, Carolina de Vargas Nunes Coll, Kelly Evenson
BACKGROUND: Women are encouraged to be physically active during pregnancy. Despite available evidence supporting antenatal physical activity to bring health benefits for both the mother and child, the most effective way to prevent some maternal and fetal outcomes is still unclear. The purpose of this study was to evaluate the efficacy of an exercise intervention to prevent negative maternal and newborn health outcomes. METHODS: A randomized controlled trial (RCT) nested into the 2015 Pelotas (Brazil) Birth Cohort Study was carried-out with 639 healthy pregnant women, 213 in the intervention group (IG) and 426 in the control (CG) group...
December 22, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29251202/cd15-as-a-marker-of-fetoplacental-endothelial-immaturity-in-iugr-placentas
#20
Gayatri Ravikumar, Julian Crasta, Jyothi S Prabhu, Tinku Thomas, Pratibha Dwarkanath, Annamma Thomas, Anura V Kurpad, Tirumalai Srinivas Sridhar
BACKGROUND: Structural or functional defects in the placenta, are the primary cause of growth restriction of the fetus. Morphological examination of such placentas from intrauterine growth restricted (IUGR) fetuses often appears deceptively normal. Evaluation of angiogenesis and fetoplacental vasculature is critical to understand the underlying pathogenesis of fetal growth restriction in both idiopathic as well as cases where it is thought to be secondary to complications like preeclampsia (PE)...
December 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
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