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https://www.readbyqxmd.com/read/29138036/aspirin-for-the-prevention-of-preterm-and-term-preeclampsia-systematic-review-and-meta-analysis
#1
Stephanie Roberge, Emmanuel Bujold, Kypros H Nicolaides
BACKGROUND: Meta-analyses of randomized controlled trials have reported contradictory results concerning the effect of aspirin in the prevention of preeclampsia both in terms of the gestational age at the onset of treatment and the dose of the drug. The controversy may be resolved by a meta-analysis that includes several recently published trials and particularly the large Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial and by examining whether there is a difference of the effect of aspirin on preterm vs...
November 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29130759/preeclampsia-in-pregnancies-complicated-by-sle-nephritis-prophylactic-treatment-with-multidisciplinary-approach-are-important-keys-to-prevent-adverse-obstetrics-outcomes
#2
Federico Mecacci, Serena Simeone, Calogero Lino Cirami, Mauro Cozzolino, Caterina Serena, Marianna Pina Rambaldi, Pamela Gallo, Lorenzo Emmi, Daniele Cammelli, Giorgio Mello, Marco Matucci Cerinic
INTRODUCTION: Systemic lupus erythematosus (SLE) commonly affects women of childbearing age. Hypertension, antiphospholipid syndrome and lupus nephritis are risk factors for adverse maternal/fetal outcome. The aim of this retrospective cohort study is to compare pregnancy outcomes in patients with and without SLE nephritis, using a multidisciplinary approach and a broad prophylaxis protocol. MATERIALS AND METHODS: Data were collected from 86 pregnancies complicated by SLE...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29125627/placental-development-and-function-in-women-with-a-history-of-placenta-related-complications-a-systematic-review
#3
Ignatia F Reijnders, Annemarie G M G J Mulders, Maria P H Koster
INTRODUCTION: Women with a history of placenta-related pregnancy complications, such as preeclampsia, intra-uterine growth restriction or preterm delivery, have an increased risk for recurrence of such complications. This recurrence is likely the result of underlying endothelial dysfunction that leads to abnormal placentation, especially in complications with an early onset. This study provides an overview of biomarkers of placental development and function in pregnancies from women with a history of pregnancy-related complications...
November 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29113124/role-of-placental-vdr-expression-and-function-in-common-late-pregnancy-disorders
#4
REVIEW
Julia Knabl, Aurelia Vattai, Yao Ye, Julia Jueckstock, Stefan Hutter, Franz Kainer, Sven Mahner, Udo Jeschke
Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29112657/placental-complications-associated-with-psychostimulant-use-in-pregnancy
#5
Jacqueline M Cohen, Sonia Hernández-Díaz, Brian T Bateman, Yoonyoung Park, Rishi J Desai, Kathryn J Gray, Elisabetta Patorno, Helen Mogun, Krista F Huybrechts
OBJECTIVE: To evaluate whether psychostimulants used to treat attention-deficit/hyperactivity disorder (ADHD) are associated with risk of adverse placental-associated pregnancy outcomes including preeclampsia, placental abruption, growth restriction, and preterm birth. METHODS: We designed a population-based cohort study in which we examined a cohort of pregnant women and their liveborn neonates enrolled in Medicaid from 2000 to 2010. Women who received amphetamine-dextroamphetamine or methylphenidate monotherapy in the first half of pregnancy were compared with unexposed women...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29111424/abnormal-mid-trimester-cardiac-strain-in-women-with-chronic-hypertension-predates-superimposed-preeclampsia
#6
Sajid Shahul, Hadi Ramadan, Ariel Mueller, Junaid Nizamuddin, Rabab Nasim, Joana Lopes Perdigao, Sireesha Chinthala, Avery Tung, Sarosh Rana
BACKGROUND: Chronic hypertension (cHTN) affects 7% of all pregnancies. We hypothesized that cHTN during pregnancy would be associated with abnormal myocardial strain patterns and adverse perinatal outcomes. METHODS: This was a retrospective cohort study of patients seen in a high-risk obstetrics clinic with cHTN. Parturients with a singleton pregnancy who had undergone an echocardiogram as part of routine clinical care were eligible. Clinical and demographic information was collected from medical records...
October 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29107602/maternal-ophthalmic-artery-doppler-ultrasonography-in-preeclampsia-and-pregnancy-outcomes
#7
Maria Teresa Pedrazzi Chaves, Sérgio Martins-Costa, Maria Lúcia da Rocha Oppermann, Ricardo Palma Dias, Valentino Magno, Julio Alejandro Peña, José Geraldo Lopes Ramos
OBJECTIVE: To examine the association of ophthalmic artery (OA) Doppler measure - the ratio of velocity peaks (PR) - to adverse pregnancy outcomes in preeclampsia. STUDY DESIGN AND MAIN OUTCOMES: Prospective cohort study of 56 women with preeclampsia that underwent Doppler measurements of OA flow, medial to optic nerve. PR results were classified as normal (PR < 0.78), abnormal (PR 0.78-0.98), or highly abnormal (PR ≥ 0.99). Attending clinicians were blinded to OA Doppler results...
October 19, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29106560/preeclampsia-mediates-the-association-between-shorter-height-and-increased-risk-of-preterm-delivery
#8
Naho Morisaki, Kohei Ogawa, Kevin Y Urayama, Haruhiko Sago, Shoji Sato, Shigeru Saito
Background: Maternal short stature has been observed to increase the risk of preterm birth; however, the aetiology behind this phenomenon is unknown. We investigated whether preeclampsia, an obstetric complication that often leads to preterm delivery and is reported to have an inverse association with women's height, mediates this association. Methods: We studied 218 412 women with no underlying diseases before pregnancy, who delivered singletons from 2005 to 2011 and were included in the Japan Society of Obstetrics and Gynecology perinatal database, which is a national multi-centre-based delivery database among tertiary hospitals...
October 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29096631/prediction-of-uncomplicated-pregnancies-in-obese-women-a-prospective-multicentre-study
#9
Matias C Vieira, Sara L White, Nashita Patel, Paul T Seed, Annette L Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M Nelson, Debbie A Lawlor, Lucilla Poston, Dharmintra Pasupathy
BACKGROUND: All obese pregnant women are considered at equal high risk with respect to complications in pregnancy and birth, and are commonly managed through resource-intensive care pathways. However, the identification of maternal characteristics associated with normal pregnancy outcomes could assist in the management of these pregnancies. The present study aims to identify the factors associated with uncomplicated pregnancy and birth in obese women, and to assess their predictive performance...
November 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29095432/pregnancy-induced-hypertension-and-neonatal-outcomes-a-systematic-review-and-meta-analysis
#10
A Razak, A Florendo-Chin, L Banfield, M G Abdul Wahab, S McDonald, P S Shah, A Mukerji
OBJECTIVE: Pregnancy-induced hypertension (PIH) is associated with preterm delivery but its independent impact on neonatal outcomes remains unclear. We sought to systematically review and meta-analyze clinical outcomes of preterm infants <37 weeks' gestation born to mothers with and without PIH. STUDY DESIGN: Medline, Embase, PsychINFO and CINAHL were searched from January 2000 to October 2016. Studies with low-moderate risk of bias reporting neonatal outcomes based on PIH as primary exposure variable were included...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29091257/are-women-positive-for-the-one-step-but-negative-for-the-two-step-screening-tests-for-gestational-diabetes-at-higher-risk-for-adverse-outcomes
#11
Claudia Caissutti, Adeeb Khalifeh, Gabriele Saccone, Vincenzo Berghella
INTRODUCTION: To evaluate if women meeting criteria for gestational diabetes mellitus (GDM) by the One Step test as per International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by other less strict criteria have adverse pregnancy outcomes compared to GDM negative controls. The primary outcome was the incidence of macrosomia, defined as birth weight >4,000 grams. MATERIAL AND METHODS: Electronic databases were searched from their inception until May 2017...
November 1, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29082792/evaluation-of-late-adolescent-pregnancies-is-late-adolescence-a-risk-factor-for-preterm-labor
#12
Sunullah Soysal, Abdullah Sarioz, Gokce Anik Ilhan, Ali Kocagoz, Aylin Dizi, Ilhan Gursoy, Ipek Celik, Damla Ozmen
STUDY OBJECTIVE: We evaluated effect of late adolescence during pregnancy and its confounding factors on neonatal and maternal results. OBJECTIVE: The aim of the present study is to evaluate the effect of late adolescence on maternal, perinatal outcomes and preterm labor. METHODS: This retrospective study was carried out on 172 late adolescents and 160 adult women who delivered in a tertiary center. The demographic features, obstetrical and neonatal properties of the patients were analyzed...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29082786/the-mediterranean-diet-adherence-by-pregnant-women-delivering-prematurely-association-with-size-at-birth-and-complications-of-prematurity
#13
Elisavet Parlapani, Charalampos Agakidis, Thomais Karagiozoglou-Lampoudi, Kosmas Sarafidis, Eleni Agakidou, Apostolos Athanasiadis, Elisavet Diamanti
BACKGROUND: The Mediterranean diet (MD) is associated with decreased risk of metabolic syndrome and gestational diabetes due to the anti-inflammatory and antioxidative properties of its components. The aim was to investigate the potential association of MD adherence (MDA) during pregnancy by mothers delivering prematurely, with intrauterine growth as expressed by neonates' anthropometry at birth and complications of prematurity. PARTICIPANTS AND METHODS: This is a single-center, prospective, observational cohort study of 82 women who delivered preterm singletons at post conceptional age (PCA) ≤ 34 weeks and their live-born neonates...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29082782/how-do-maternal-factors-impact-preeclampsia-prediction-in-brazilian-population
#14
Karina Bilda de Castro Rezende, Antônio José Ledo Alves da Cunha, Cristos Pritsivelis, Edson Chaves Faleiro, Joffre Amim Junior, Rita Guérios Bornia
OBJECTIVE: To evaluate the impacts of maternal risk factors described by the Fetal Medicine Foundation's 2012 algorithm (FMF2012) in a Brazilian population. METHODS: All singleton pregnancies submitted to first-trimester preeclampsia (PE) screening using the FMF2012 algorithm were considered for study inclusion. Maternal factors, recorded via a patient questionnaire, were described and compared between PE outcome groups. A Gaussian regression model was derived to measure the effects of maternal factors, and to identify factors that contributed significantly (p < 0...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29082781/body-mass-index-and-the-risk-of-hypertensive-disorders-of-pregnancy-the-great-obstetrical-syndromes-gos-study
#15
Cédric Gasse, Amélie Boutin, Suzanne Demers, Nils Chaillet, Emmanuel Bujold
OBJECTIVE: To estimate the association between first-trimester body mass index (BMI) and the different types of hypertensive disorders of pregnancy (HDP). METHODS: A prospective cohort of nulliparous women recruited at 11-13 weeks. Height and weight were measured and BMI was reported as binary (more or less than 30 kg/m(2)), categorical (World Health Organization classification), and continuous variables. Participants were followed for development of any HDP, including preeclampsia and preterm preeclampsia...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29079144/society-for-maternal-fetal-medicine-smfm-consult-series-44-management-of-bleeding-in%C3%A2-the-late-preterm-period
#16
Cynthia Gyamfi-Bannerman
Third-trimester bleeding is a common complication arising from a variety of etiologies, some of which may initially present in the late preterm period. Previous management recommendations have not been specific to this gestational age window, which carries a potentially lower threshold for delivery. The purpose of this document is to provide guidance on management of late preterm (34 0/7-36 6/7 weeks of gestation) vaginal bleeding. The following are Society for Maternal-Fetal Medicine recommendations: (1) we recommend delivery at 36-37 6/7 weeks of gestation for stable women with placenta previa without bleeding or other obstetric complications, such as preeclampsia or fetal growth restriction (Grade 1B); (2) we do not recommend routine cervical length screening for women with placenta previa in the late preterm period because of a lack of data on an appropriate management strategy (Grade 2C); (3) we recommend a planned delivery between 34 and 37 weeks of gestation for stable women with placenta accreta (Grade 1C); (4) we recommend delivery between 34 and 37 weeks of gestation for stable women with vasa previa (Grade 1C); (5) we recommend that in women with active hemorrhage in the late preterm period, delivery should not be delayed for the purpose of administering antenatal corticosteroids (Grade 1B); (6) we recommend that fetal lung maturity testing should not be used to guide management in the late preterm period when an indication for delivery is present (Grade 1B); and (7) we recommend that antenatal corticosteroids should be administered to women who are eligible and are managed expectantly if delivery is likely within 7 days, the gestational age is between 34 0/7 and 36 6/7 weeks of gestation, and antenatal corticosteroids has not previously been administered (Grade 1A)...
October 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29079078/maternal-characteristics-for-the-prediction-of-preeclampsia-in-nulliparous-women-the-great-obstetrical-syndromes-gos-study
#17
Amélie Boutin, Cédric Gasse, Suzanne Demers, Yves Giguère, Amélie Tétu, Emmanuel Bujold
OBJECTIVE: Low-dose aspirin started in early pregnancy significantly reduces the risk of preeclampsia (PE) in high-risk women, especially preterm PE. This study aimed to evaluate the influence of maternal characteristics on the risk of PE in nulliparous women. METHODS: The Great Obstetrical Syndromes (GOS) study recruited nulliparous women with singleton pregnancies at 11 to 13 weeks. The following maternal characteristics were collected: age, BMI, ethnicity, chronic diseases, smoking, and assisted reproductive technologies...
October 24, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29067240/benign-thyroid-disease-in-pregnancy-a-state-of-the-art-review
#18
REVIEW
Efterpi Tingi, Akheel A Syed, Alexis Kyriacou, George Mastorakos, Angelos Kyriacou
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid disease on pregnancy and the current evidence on the management of different thyroid conditions in pregnancy and postpartum to improve fetal and neonatal outcomes, with special reference to existing guidelines on the topic which we dissect, critique and compare with each other...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29065730/fetal-hydrops-and-the-risk-of-severe-preeclampsia
#19
Richard M Burwick, Rachel A Pilliod, Stephanie E Dukhovny, Aaron B Caughey
OBJECTIVE: To assess the incidence and severity of preeclampsia in pregnancies complicated by fetal hydrops. METHODS: We performed a retrospective cohort study of singleton gestations from 2005-2008 in California. The primary predictor was fetal hydrops and the primary outcome was preeclampsia. Selected adverse maternal and neonatal events were assessed as secondary outcomes. Potential confounders examined included fetal anomalies, polyhydramnios, race/ethnicity, nulliparity, chronic hypertension, and gestational or pregestational diabetes mellitus...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29064265/pregnancy-complications-and-wheezing-and-asthma-in-childhood
#20
Franca Rusconi, Luigi Gagliardi
This review focuses on recent advances in the field of several frequent maternal complications in pregnancy and asthma and wheezing in childhood, for which large birth cohort studies have recently provided clues. Within the framework of epidemiologic studies, we discuss potential mechanisms, mediators and confounders involved in associations, in an attempt to discern causal pathways. Preeclampsia, a pregnancy-specific multiorgan disease that affects 2-4% of women in developed countries, is characterized by placental dysfunction and is associated with preterm delivery, fetal growth restriction and vascular and lung effects in the fetus...
October 24, 2017: American Journal of Respiratory and Critical Care Medicine
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