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Best-worst scaling

Henock G Yebyo, Hélène E Aschmann, Tsung Yu, Milo A Puhan
BACKGROUND: Patient preferences are key parameters to evaluate benefit-harm balance of statins for primary prevention but they are not readily available to guideline developers and decision makers. Our study aimed to elicit patient preferences for benefit and harm outcomes related to use of statins for primary cardiovascular disease prevention and to examine how the preferences differ across economically and socio-culturally different environments. METHODS: We conducted preference-eliciting surveys using best-worst scaling designed with a balanced incomplete-block design (BIBD) on 13 statins-related outcomes on 220 people in Ethiopia and Switzerland...
May 18, 2018: BMC Cardiovascular Disorders
V M Merlino, D Borra, V Girgenti, A Dal Vecchio, S Massaglia
In this research the importance of several choice attributes of beef for Piedmontese consumers was examined. The survey was conducted on a sample of consumers in sixteen meat stores in Piedmont, Northwest Italy. A choice experiment (Best-Worst scaling methodology) was used to identify consumer preferences and five clusters of purchaser. The responses were also analyzed on the basis of two variables, the frequency of meat consumption and the place of purchase. Piedmontese consumers considered "price" as the most important factor in meat purchasing, but "animal welfare" considerations played some part too...
April 23, 2018: Meat Science
Emma E Bleasdale, Sam N Thrower, Andrea Petróczi
Background: 2,4-Dinitrophenol (2,4-DNP) is an effective but highly dangerous fat burner, not licensed for human consumption. Death cases reported for 2,4-DNP overdose, particularly among young adults, have raised concerns about the ineffective regulatory control, lack of education and risks associated with impurity, and the unknown concentration of 2,4-DNP purchased on the Internet. Methods: Using a sequential mixed method design and based on a hypothetical scenario as if 2,4-DNP was a licensed pharmaceutical drug, first we conducted a qualitative study to explore what product attributes people consider when buying a weight-loss aid...
2018: Frontiers in Psychiatry
John Fp Bridges, Allison H Oakes, Crystal A Reinhart, Ernest Voyard, Bernadette O'Donoghue
Background: Acute myeloid leukemia (AML) is a rapidly progressing blood cancer for which new treatments are needed. We sought to promote patient-focused drug development (PFDD) for AML by developing and piloting an instrument to prioritize the worries of patients with AML. Patients and methods: An innovative community-centered approach was used to engage expert and community stakeholders in the development, pretesting, pilot testing, and dissemination of a novel best-worst scaling instrument...
2018: Patient Preference and Adherence
Anne Frisch, Thula C Walter, Christian Grieser, Dominik Geisel, Bernd Hamm, Timm Denecke
Background: Orally administered substances, which reduce image contamination by overlying gastrointestinal fluid signals, can be used to enhance the quality of MRCP images. Recently, a new standardized formula consisting of biological substances has become available. The objective of this study is to provide a first assessment of achievable MRCP image quality, taste and palatability of this new dedicated agent. Methods: In January 2015 to May 2015 practicing radiologists in Germany, Austria and Switzerland were asked to evaluate image quality as well as taste and palatability when using the new agent (LumiVision® ; b...
2018: European Journal of Radiology Open
Ellen M Janssen, Heather L Benz, Jui-Hua Tsai, John Fp Bridges
OBJECTIVE: We identified and prioritized concerns reported by stakeholders associated with novel upper-limb prostheses. METHODS: An evidence review and key-informant engagement, identified 62 concerns with upper-limb prostheses with implantable components. We selected 16 concerns for inclusion in a best-worst scaling (BWS) prioritization survey. Focus groups and BWS were used to engage stakeholders at a public meeting on prostheses. In 16 BWS choice tasks, attendees selected the most and least influential concern when choosing an upper-limb prosthesis...
April 30, 2018: Expert Review of Medical Devices
Nacho Castejón, Joseph C Cappelleri, Jesús Cuervo, Kathryn Lang, Priyanka Mehta, Ruth Mokgokong, Carla Mamolo
BACKGROUND: Health state (HS) utility values for patients with acute myeloid leukemia (AML), a hematological malignancy, are not available in the United Kingdom (UK). This study aims to develop clinically sound HSs for previously untreated patients with AML and to assign utility values based on preferences of the general UK population. METHODS: This study was conducted in the UK and comprised 2 stages. During the first stage, AML HSs were drafted based on evidence from a literature review of AML clinical and health-related quality-of-life studies (published January 2000-June 2016) and patient-reported outcome measures previously used in this population...
April 18, 2018: Health and Quality of Life Outcomes
Alex Reivitis, Kian Karimi, Chester Griffiths, Ashley Banayan
BACKGROUND: Topical treatments containing tripeptide and hexapeptide (TriHex technology) have been proven to contribute to youthful skin by clearing the extracellular matrix and stimulating collagen and elastin production. OBJECTIVE: Evaluate the efficacy of a novel eye treatment containing TriHex peptides and other synergistic ingredients for the daily treatment of fine lines/crow's feet around the eyes, under eye hollowing, under eye bags, and dark circles. PATIENTS/METHODS: In this study, 10 subjects (9 female and 1 male) aged 30-60 of Fitzpatrick skin type I, II, or III were selected to use an eye treatment containing TriHex peptides and active botanicals (Alastin Restorative Eye Treatment with TriHex Technology™, ALASTIN Skincare, Inc...
April 16, 2018: Journal of Cosmetic Dermatology
Sachiko Ozawa, Mo Zhou, Chizoba Wonodi, Hui-Han Chen, John F P Bridges
BACKGROUND: Routine childhood immunization coverage has been low in northern Nigeria. While local authorities and international partners have been working hard to improve coverage, population preferences for interventions have not been documented. This study aimed to understand parents' preferences and identify possible interventions to improve uptake of childhood immunization. METHODS: Preferences for immunization interventions were elicited using a best-worst scaling (BWS) instrument among parents with children under five...
April 13, 2018: Vaccine
Abed Ghandour, Andrew Sher, Negin Rassouli, Amar Dhanantwari, Prabhakar Rajiah
OBJECTIVE: To evaluate the ability of retrospectively generated virtual monoenergetic images (VMIs) from the detector-based spectral computed tomography (SDCT) to augment pulmonary artery enhancement in CT and if iodine map can predict the optimal monoenergetic level. METHODS: The study included 79 patients with contrast-enhanced chest CT scans on an SDCT scanner. Conventional 120-kVp images and VMI from 40 to 80 keV were generated. Attenuation, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were measured at 7 different locations in the pulmonary arterial system...
April 13, 2018: Journal of Computer Assisted Tomography
Claire A Lawson, Ivonne Solis-Trapala, Ulf Dahlstrom, Mamas Mamas, Tiny Jaarsma, Umesh T Kadam, Anna Stromberg
BACKGROUND: Optimally treated heart failure (HF) patients often have persisting symptoms and poor health-related quality of life. Comorbidities are common, but little is known about their impact on these factors, and guideline-driven HF care remains focused on cardiovascular status. The following hypotheses were tested: (i) comorbidities are associated with more severe symptoms and functional limitations and subsequently worse patient-rated health in HF, and (ii) these patterns of association differ among selected comorbidities...
March 2018: PLoS Medicine
Sarah Tebrügge, Angela Winkler, Diana Gerards, Christian Weimar, Susanne Moebus, Karl-Heinz Jöckel, Raimund Erbel, Martha Jokisch
BACKGROUND: There is strong evidence for an association of olfactory dysfunction and neurodegenerative diseases. Studies on the association of olfaction and cognition in the general population are rare. OBJECTIVE: To evaluate gender- and age-specific associations of olfactory function and cognitive performance in a well characterized population-based study sample. METHODS: At the third examination of the Heinz Nixdorf Recall study (n = 3,087), 2,640 participants (48% men; 68...
March 23, 2018: Journal of Alzheimer's Disease: JAD
Carlos Zaror, Yolanda Pardo, Gerardo Espinoza-Espinoza, Àngels Pont, Patricia Muñoz-Millán, María José Martínez-Zapata, Gemma Vilagut, Carlos G Forero, Olatz Garin, Jordi Alonso, Montse Ferrer
OBJECTIVES: To obtain a systematic and standardized evaluation of the current evidence on development process, metric properties, and administration issues of oral health-related quality of life instruments available for children and adolescents. MATERIALS AND METHODS: A systematic search until October 2016 was conducted in PubMed, Embase, Lilacs, SciELO, and Cochrane databases. Articles with information regarding the development process, metric properties, and administration issues of pediatric instruments measuring oral health-related quality of life were eligible for inclusion...
March 22, 2018: Clinical Oral Investigations
William Walker, Katherine A Stromberg, Jennifer H Marwitz, Adam Sima, Amma A Agyemang, Kristin M Graham, Cynthia L Harrison-Felix, Jeanne Hoffman, Allen W Brown, Jeffrey S Kreutzer, Randall Merchant
For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Outcome Scale (GOS) functional levels at 1, 2, and 5-years after moderate to severe closed TBI. Flexible classification tree statistical modeling was used on prospectively collected data from the TBI-Model Systems (TBIMS) inception cohort study...
March 22, 2018: Journal of Neurotrauma
Jesus Sainz, Carlos Prieto, Fulgencio Ruso-Julve, Benedicto Crespo-Facorro
Antipsychotic drugs are one of the largest types of prescribed drugs and have large inter-individual differences in efficacy, but there is no methodology to predict their clinical effect. Here we show a four-gene blood expression profile to predict the response to antipsychotics in schizophrenia patients before treatment. We sequenced total mRNA from blood samples of antipsychotic naïve patients who, after 3 months of treatment, were in the top 40% with the best response (15 patients) and in the bottom 40% with the worst response (15 patients) according to the Brief Psychiatric Rating Scale (BPRS)...
2018: Frontiers in Molecular Neuroscience
Florian Dams, Javier Leonardo Gonzalez Rodriguez, Kei Long Cheung, Ben F M Wijnen, Mickaël Hiligsmann
OBJECTIVES: Several studies, mostly from developed countries, have identified barriers and facilitators with regard to the uptake of health technology assessment (HTA). This study elicited, using best-worst scaling (BWS), what HTA experts in Colombia consider to be the most important barriers and facilitators in the use of HTA, and makes a comparison to results from the Netherlands. METHODS: Two object case surveys (one for barriers, one for facilitators) were conducted among 18 experts (policymakers, health professionals, PhD students, senior HTA-researchers) from Colombia...
May 2018: Journal of Medical Economics
Cordula Braun, Helen H Handoll
BACKGROUND: Knowledge about Minimal Important Differences (MIDs) is essential for the interpretation of continuous outcomes, especially patient-reported outcome measures (PROMS). OBJECTIVE: The aim of this study was to estimate the MID for the Western Ontario Rotator Cuff Index (WORC: score 0 (best) to 2100 (worst disability)) in adults with shoulder pain associated with partial-thickness rotator cuff tears, 'symptomatic PTTs', undergoing conservative treatment with physiotherapy...
June 2018: Musculoskeletal Science & Practice
Wendy Camelo Castillo, Melissa Ross, Saad Tariq, Susan dosReis
OBJECTIVE: Health care decision-making for youth with mental health multimorbidity is guided by outcomes that are considered most meaningful and important. The study objective was to pilot test a best-worst scaling (BWS) instrument designed to assess trade-offs among caregiver-defined, meaningful health care outcomes. METHODS: A BWS was designed with continuous stakeholder involvement to elicit caregiver-defined outcomes in 4 domains: school, behavioral, social, and independence...
February 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Melissa Ross, Vy Nguyen, John F P Bridges, Xinyi Ng, Gloria Reeves, Emily Frosch, Susan dosReis
OBJECTIVE: To document variability among caregivers' priorities when considering medication to treat their Children's attention-deficit hyperactivity disorder (ADHD) and explore associations between these priorities and medication-related improvements. METHODS: Caregivers of children, ages 4 to 14 years, diagnosed with ADHD were recruited from outpatient clinics and support groups across Maryland. A survey gathered data on caregiver-reported concerns when considering ADHD medication, demographic characteristics, and observed and desired improvements in their child's ADHD...
February 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Vala Flosadottir, Richard Frobell, Ewa M Roos, Eva Ageberg
BACKGROUND: In people with anterior cruciate ligament (ACL) injury, high self-efficacy facilitates recovery, indicated by improved muscle function, reduced knee symptoms and increased physical activity. Impact of treatment on future self-efficacy is however not well investigated. The aims of the study were to 1) investigate knee-related self-efficacy 6 years after acute ACL injury in patients treated with exercise therapy alone or in combination with either early or the option of delayed ACL reconstruction (ACLR), and 2) to investigate associations between single-leg physical performance at various time points after ACL injury and knee self-efficacy at 6 years after injury...
February 13, 2018: BMC Musculoskeletal Disorders
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