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Parkingson's

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https://www.readbyqxmd.com/read/25063512/degradation-of-misfolded-proteins-by-autophagy-is-it-a-strategy-for-huntington-s-disease-treatment
#1
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Fang Lin, Zheng-Hong Qin
Autophagy is a degradation pathway for long-lived cytoplasmic proteins, protein complexes, or damaged organelles. The accumulation and aggregation of misfolded proteins are hallmarks of several neurodegenerative diseases. Many researchers have reported that autophagy degrades disease-causing misfolded and aggregated proteins, including mutant huntingtin (Htt) in Huntington's disease, mutant synuclein in familial Parkingson's disease, mutant Cu, Zn-Superoxide dismutase (SOD1) in familial amyotrophic lateral sclerosis...
2013: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/23123341/conversion-of-natively-unstructured-%C3%AE-synuclein-to-its-%C3%AE-helical-conformation-significantly-attenuates-production-of-reactive-oxygen-species
#2
Binbin Zhou, Yuanqiang Hao, Chengshan Wang, Ding Li, You-Nian Liu, Feimeng Zhou
The intracellular α-synuclein (α-syn) protein, whose conformational change and aggregation have been closely linked to the pathology of Parkingson's disease (PD), is highly populated at the presynaptic termini and remains there in the α-helical conformation. In this study, circular dichroism confirmed that natively unstructured α-syn in aqueous solution was transformed to its α-helical conformation upon addition of trifluoroethanol (TFE). Electrochemical and UV-visible spectroscopic experiments reveal that both Cu (I) and Cu (II) are stabilized, with the former being stabilized by about two orders of magnitude...
January 2013: Journal of Inorganic Biochemistry
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