keyword
MENU ▼
Read by QxMD icon Read
search

model-based model-free

keyword
https://www.readbyqxmd.com/read/28227910/development-of-a-three-dimensional-lattice-free-multiscale-model-of-the-mammary-terminal-end-bud
#1
Joseph D Butner, Vittorio Cristini, Zhihui Wang, Joseph D Butner, Vittorio Cristini, Zhihui Wang, Vittorio Cristini, Joseph D Butner, Zhihui Wang
The terminal end bud (TEB) is a bulbous structure composed of highly proliferative cells that is responsible for mammary gland development during the pubertal stage. This is a highly organized process, involving cellular differentiation hierarchies regulated by endocrine and paracrine signaling. Here, we present development of a lattice-free, three dimensional multiscale agent based model of the TEB to study the effects of cellular phenotypic hierarchies, endocrine and paracrine signaling, and proliferation demographics on pubertal mammary gland development...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227751/a-time-domain-frequency-selective-multivariate-granger-causality-approach
#2
Lutz Leistritz, Herbert Witte, Lutz Leistritz, Herbert Witte, Lutz Leistritz, Herbert Witte
The investigation of effective connectivity is one of the major topics in computational neuroscience to understand the interaction between spatially distributed neuronal units of the brain. Thus, a wide variety of methods has been developed during the last decades to investigate functional and effective connectivity in multivariate systems. Their spectrum ranges from model-based to model-free approaches with a clear separation into time and frequency range methods. We present in this simulation study a novel time domain approach based on Granger's principle of predictability, which allows frequency-selective considerations of directed interactions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227617/detection-of-chewing-from-piezoelectric-film-sensor-signals-using-ensemble-classifiers
#3
Muhammad Farooq, Edward Sazonov, Muhammad Farooq, Edward Sazonov, Muhammad Farooq, Edward Sazonov
Selection and use of pattern recognition algorithms is application dependent. In this work, we explored the use of several ensembles of weak classifiers to classify signals captured from a wearable sensor system to detect food intake based on chewing. Three sensor signals (Piezoelectric sensor, accelerometer, and hand to mouth gesture) were collected from 12 subjects in free-living conditions for 24 hrs. Sensor signals were divided into 10 seconds epochs and for each epoch combination of time and frequency domain features were computed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227445/quantitative-estimation-of-electro-osmosis-force-on-charged-particles-inside-a-borosilicate-resistive-pulse-sensor
#4
Mostafa Ghobadi, Yuqian Zhang, Ankit Rana, Ehsan T Esfahani, Leyla Esfandiari, Mostafa Ghobadi, Yuqian Zhang, Ankit Rana, Ehsan T Esfahani, Leyla Esfandiari, Ehsan T Esfahani, Yuqian Zhang, Ankit Rana, Mostafa Ghobadi
Nano and micron-scale pore sensors have been widely used for biomolecular sensing application due to its sensitive, label-free and potentially cost-effective criteria. Electrophoretic and electroosmosis are major forces which play significant roles on the sensor's performance. In this work, we have developed a mathematical model based on experimental and simulation results of negatively charged particles passing through a 2μm diameter solid-state borosilicate pore under a constant applied electric field. The mathematical model has estimated the ratio of electroosmosis force to electrophoretic force on particles to be 77...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227131/sound-preference-test-in-animal-models-of-addicts-and-phobias
#5
Ryo Soga, Tomoyo I Shiramatsu, Ryohei Kanzaki, Hirokazu Takahashi, Ryo Soga, Tomoyo I Shiramatsu, Ryohei Kanzaki, Hirokazu Takahashi, Tomoyo I Shiramatsu, Ryohei Kanzaki, Ryo Soga, Hirokazu Takahashi
Biased or too strong preference for a particular object is often problematic, resulting in addiction and phobia. In animal models, alternative forced-choice tasks have been routinely used, but such preference test is far from daily situations that addicts or phobic are facing. In the present study, we developed a behavioral assay to evaluate the preference of sounds in rodents. In the assay, several sounds were presented according to the position of free-moving rats, and quantified the sound preference based on the behavior...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226779/biologically-inspired-design-of-feedback-control-systems-implemented-using-dna-strand-displacement-reactions
#6
Mathias Foo, Rucha Sawlekar, Vishwesh V Kulkarni, Declan G Bates, Mathias Foo, Rucha Sawlekar, Vishwesh V Kulkarni, Declan G Bates, Vishwesh V Kulkarni, Rucha Sawlekar, Declan G Bates, Mathias Foo
The use of abstract chemical reaction networks (CRNs) as a modelling and design framework for the implementation of computing and control circuits using enzyme-free, entropy driven DNA strand displacement (DSD) reactions is starting to garner widespread attention in the area of synthetic biology. Previous work in this area has demonstrated the theoretical plausibility of using this approach to design biomolecular feedback control systems based on classical proportional-integral (PI) controllers, which may be constructed from CRNs implementing gain, summation and integrator operators...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226767/place-field-detection-using-grid-based-clustering-in-a-large-scale-computational-model-of-the-rat-dentate-gyrus
#7
Gene J Yu, Dong Song, Theodore W Berger, Gene J Yu, Dong Song, Theodore W Berger, Dong Song, Gene J Yu, Theodore W Berger
Place cells are neurons in the hippocampus that are sensitive to location within an environment. Simulations of a large-scale, computational model of the rat dentate gyrus using grid cell input have been performed resulting in granule cells that express multiple place fields. The typical method of detecting place fields using a global threshold on this data is unreliable as the characteristics of the place fields from a single neuron can be highly variable. A grid-based implementation of DENCLUE has been developed to calculate local thresholds to identify each place field...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226661/optimal-weighted-averaging-of-event-related-activity-from-acquisitions-with-artifacts
#8
Luca Vollero, Sara Petrichella, Giulio Innello, Luca Vollero, Sara Petrichella, Giulio Innello, Luca Vollero, Sara Petrichella, Giulio Innello
In several biomedical applications that require the signal processing of biological data, the starting procedure for noise reduction is the ensemble averaging of multiple repeated acquisitions (trials). This method is based on the assumption that each trial is composed of two additive components: (i) a time-locked activity related to some sensitive/stimulation phenomenon (ERA, Event Related Activity in the following) and (ii) a sum of several other non time-locked background activities. The averaging aims at estimating the ERA activity under very low Signal to Noise and Interference Ratio (SNIR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226649/heart-rate-independent-qt-variability-component-can-detect-subclinical-cardiac-autonomic-neuropathy-in-diabetes
#9
Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami, Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami, Ahsan H Khandoker, Herbert F Jelinek, Chandan K Karmakar, Mohammad H Imam, M Palaniswami
Cardiac autonomic neuropathy (CAN) may lead to life threatening arrhythmia due to denervation of both the parasympathetic and sympathetic branches of autonomic nervous system innervating the heart. CAN is a frequently under diagnosed complication of diabetes, because a patient can have asymptomatic CAN for several years before it is clinically apparent. However, detection of CAN at the early or subclinical stage leads to more effective treatment outcomes. Cardiac autonomic reflex tests (CART) (i.e. Ewing test battery) are normally used for the detection and staging of CAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226483/experimental-evaluation-of-regression-model-based-walking-speed-estimation-using-lower-body-mounted-imu
#10
Shaghayegh Zihajehzadeh, Edward J Park, Shaghayegh Zihajehzadeh, Edward J Park, Shaghayegh Zihajehzadeh, Edward J Park
This study provides a concurrent comparison of regression model-based walking speed estimation accuracy using lower body mounted inertial sensors. The comparison is based on different sets of variables, features, mounting locations and regression methods. An experimental evaluation was performed on 15 healthy subjects during free walking trials. Our results show better accuracy of Gaussian process regression compared to least square regression using Lasso. Among the variables, external acceleration tends to provide improved accuracy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226400/population-pharmacokinetics-and-pharmacodynamic-target-attainment-of-ampicillin-in-neonates-with-hypoxemic-ischemic-encephalopathy-in-the-setting-of-controlled-hypothermia
#11
Jeffrey J Cies, Keri N Fugarolas, Wayne S Moore, Robert W Mason, Ogechukwu R Menkiti
STUDY OBJECTIVE: To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN: Prospective, open-label pharmacokinetic study. SETTING: 189-bed, freestanding children's tertiary care teaching hospital. PATIENTS: Thirteen neonates (three females, 10 males) with HIE encephalopathy receiving CH and ampicillin 100 mg/kg/dose intravenously every 8 hours who were admitted to the neonatal intensive care unit between May 2013 and June 2014...
February 22, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28226245/subconjunctival-injectable-dendrimer-dexamethasone-gel-for-the-treatment-of-corneal-inflammation
#12
Uri Soiberman, Siva P Kambhampati, Tony Wu, Manoj K Mishra, Yumin Oh, Rishi Sharma, Jiangxia Wang, Abdul Elah Al Towerki, Samuel Yiu, Walter J Stark, Rangaramanujam M Kannan
Corneal inflammation is often encountered as a key pathological event in many corneal diseases. Current treatments involve topical corticosteroids which require frequent instillations due to rapid tear turnover, causing side-effects such as corneal toxicity and elevated intraocular pressure (IOP). Hence, new interventions that can reduce side effects, dosing frequency, and increase patient compliance can be highly beneficial. In this study, we explore a subconjunctival injectable gel based on G4-PAMAM dendrimer and hyaluronic acid, cross-linked using thiol-ene click chemistry, incorporated with dendrimer dexamethasone (D-Dex) conjugates as a potential strategy for sustained delivery and enhanced bioavailability of corticosteroids...
February 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28226219/dietary-inflammatory-index-and-odds-of-colorectal-cancer-in-a-case-control-study-from-jordan
#13
Nitin Shivappa, James R Hébert, Susan E Steck, Lorne J Hofseth, Ihab Shehadah, Kamal E Bani-Hani, Tareq Al-Jaberi, Majed Al-Nusairr, Dennis Heath, Reema Tayyem
BACKGROUND: Dietary components that promote inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet and CRC has been investigated in several developed or Western countries. Despite the fact that dietary choices in the Middle East differ markedly from those in the West, results have not been reported from any study conducted in a Middle-Eastern population. We examined the association between dietary inflammatory index (DII)TM scores and CRC in a case-control study conducted in Jordan...
February 22, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28225628/insights-into-the-diels-alder-reaction-between-3-vinylindoles-and-methyleneindolinone-without-and-with-the-assistance-of-hydrogen-bonding-catalyst-bisthiourea-mechanism-origin-of-stereoselectivity-role-of-catalyst
#14
Chao-Xian Yan, Fan Yang, Xing Yang, Da-Gang Zhou, Pan-Pan Zhou
The Diels-Alder reaction between 3-vinylindoles and methyleneindolinone can proceed both with catalyst-free and bisthiourea catalyst, the reaction with bisthiourea is much faster and yields product with even higher stereoselectivity. The reaction mechanisms, origin of stereoselectivity and role of catalyst were elaborated based on quantum mechanical calculations and theoretical methods of reactivity indexes, NCI, QTAIM and distortion/interaction models. In uncatalyzed reaction, the two C-C bonds formed undergo the conversion from noncovalent to covalent bonding via concerted asynchronous mechanism...
February 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28225613/dehydrogenation-free-energy-of-co-2-aq-from-density-functional-theory-based-molecular-dynamics
#15
Florian H Hodel, Sandra Luber
Electron and proton transfers are important steps occurring in nature and in artificial (catalytic) reaction mechanisms. The often employed approach of calculating the energy differences of those steps using methods involving geometry optimizations neglects the influence of dynamic effects such as solvent rearrangement. To further investigate this issue and inspired by recent research in water oxidation, we calculate in the present study the dehydrogenation free energy of aqueous Co(2+), which is the free energy change associated with the first step of the reaction mechanism of model Co(II)-based water oxidation catalysts...
February 22, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28225609/regulation-and-plasticity-of-catalysis-in-enzymes-insights-from-analysis-of-mechanochemical-coupling-in-myosin
#16
Xiya Lu, Victor Ovchinnikov, Darren Demapan, Daniel Roston, Qiang Cui
The mechanism of ATP hydrolysis in the myosin motor domain is analyzed using a combination of DFTB3/CHARMM simulations and enhanced sampling techniques. The motor domain is modeled in the pre-powerstroke state, in the post-rigor state, and a hybrid model based on the post-rigor state with a closed nucleotide-binding pocket. The ATP hydrolysis activity is found to depend on the positioning of nearby water molecules, and a network of polar residues facilitates proton transfer and charge redistribution during hydrolysis...
February 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28225445/adjuvant-radiotherapy-versus-wait-and-see-strategy-for-pathologic-t3-or-margin-positive-prostate-cancer-a-meta-analysis
#17
M Parvez Shaikh, Fiori Alite, Meng-Jia Wu, Abhishek A Solanki, Matthew M Harkenrider
OBJECTIVE: To conduct a meta-analysis of the randomized controlled trials (RCTs) comparing adjuvant radiotherapy (ART) to wait-and-see (WS) strategy in pathologic T3 or margin-positive prostate cancer. METHODS: A comprehensive EMBASE, MEDLINE, http://www.clinicaltrails.gov, and Cochrane Library search for RCTs of ART versus WS was done. Results were synthesized for metastasis-free, biochemical progression-free, clinical progression-free, hormone-free, and overall survival as well as gastrointestinal (GI) and genitourinary (GU) toxicities...
February 20, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28225285/multi-scale-modeling-of-the-effects-of-salt-and-perfume-raw-materials-on-the-rheological-properties-of-commercial-thread-like-micellar-solutions
#18
Xueming Tang, Weizhong Zou, Peter H Koenig, Shawn D McConaughy, Michael R Weaver, David Michael Eike, Michael J Schmidt, Ronald G Larson
We link micellar structures to rheological properties for two surfactant body-wash formulations at various concentrations of salts and perfume raw materials (PRMs) using molecular simulations and micellar-scale modeling as well as traditional surfactant packing arguments. The two body washes, named BW-1EO and BW-3EO, are composed of sodium lauryl ethylene glycol ether sulfate (SLEnS, where n is the average number of ethylene glycol repeat units), cocamidopropyl betaine (CAPB), ACCORD (which is a mixture of six PRMs), and NaCl salt...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28225218/synthesis-of-n-n-dialkylamino-nor-dihydroxanthene-hemicyanine-fused-near-infrared-fluorophores-and-their-first-water-soluble-and-or-bioconjugatable-analogues
#19
Jean-Alexandre Richard, Michelle Jui Hsien Ong, Sylvain Debieu, Mathieu Moreau, Anthony Romieu
The effective synthesis of extended conjugated N,N-dialkylamino-nor-dihydroxanthene-based fluorophores is described from diversely functionalized salicylic aldehydes. The access to these original fluorescent derivatives proceeded in two steps through a one-pot construction of the unusual nor-dihydroxanthene (nor-DHX) scaffold followed by a diversification step providing a wide variety of nor-DHX-hemicyanine fused dyes emitting in the range 730-790 nm. The versatility of our approach has enabled a further extension to the late-stage introduction of negatively/positively charged polar groups onto their terminal nitrogen heterocyclic subunit giving access to the first water-soluble and/or bioconjugatable members of this emerging class of NIR fluorophores...
February 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28225134/phase-behaviour-and-gravity-directed-self-assembly-of-hard-convex-spherical-caps
#20
John M McBride, Carlos Avendaño
We investigate the phase behaviour and self-assembly of convex spherical caps using Monte Carlo simulations. This model is used to represent the main features observed in experimental colloidal particles with mushroom-cap shape [Riley et al., Langmuir, 2010, 26, 1648]. The geometry of this non-centrosymmetric convex model is fully characterized by the aspect ratio χ* defined as the spherical cap height to diameter ratio. We use NPT Monte Carlo simulations combined with free energy calculations to determine the most stable crystal structures and the phase behaviour of convex spherical caps with different aspect ratios...
February 22, 2017: Soft Matter
keyword
keyword
103847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"