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https://www.readbyqxmd.com/read/29031225/cube-shaped-theranostic-paclitaxel-prodrug-nanocrystals-with-surface-functionalization-of-spc-and-mpeg-dspe-for-imaging-and-chemotherapy
#1
Fuqiang Guo, Jiajia Shang, Hai Zhao, Kangrong Lai, Yang Li, Zhongxiong Fan, Zhenqing Hou, Guanghao Su
As one of nanomedicine delivery systems (NDSs), drug nanocrystals exhibited an excellent anticancer effect. Recently, differences of internalization mechanisms and subcellular localization of both drug nanocrystals and small molecular free drug have drawn much attention. In this paper, paclitaxel (PTX) as a model anticancer drug was directly labeled with 4-chloro-7-nitro-1, 2, 3-benzoxadiazole (NBD-Cl) (a drug-fluorophore conjugate Ma et al. (2016) and Wang et al. (2016) [1,2] (PTX-NBD)). PTX-NBD was synthesized by nucleophilic substitution reaction of PTX with NBD-Cl in high yield and characterized by fluorescence, XRD, ESI-MS, and FT-IR analysis...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29029307/droplet-digital-pcr-diagnosis-of-human-schistosomiasis-parasite-cell-free-dna-detection-in-diverse-clinical-samples
#2
Kosala G Weerakoon, Catherine A Gordon, Gail M Williams, Pengfei Cai, Geoffrey N Gobert, Remigio M Olveda, Allen G Ross, David U Olveda, Donald P McManus
Background: Schistosomiasis japonica remains a major public health and socio-economic concern in Southeast-Asia. Sensitive and accurate diagnostics can play a pivotal role in achieving disease elimination goals. Methods: We previously reported a novel droplet digital-PCR (ddPCR) assay targeting the mitochondrial gene nad1 to diagnose schistosomiasis japonica. The tool identified both pre-patent and patent infections using Schistosoma japonicum DNA isolated from serum, urine, salivary glands and faeces in a murine model...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028198/a-benchmark-dataset-and-saliency-guided-stacked-autoencoders-for-video-based-salient-object-detection
#3
Jia Li, Changqun Xia, Xiaowu Chen
Image-based salient object detection (SOD) has been extensively studied in past decades. However, video-based SOD is much less explored due to the lack of large-scale video datasets within which salient objects are unambiguously defined and annotated. Toward this end, this paper proposes a video-based SOD dataset that consists of 200 videos. In constructing the dataset, we manually annotate all objects and regions over 7,650 uniformly sampled keyframes and collect the eye-tracking data of 23 subjects who free-view all videos...
October 12, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29027815/l-carnosine-as-an-adjunctive-therapy-to-risperidone-in-children-with-autistic-disorder-a-randomized-double-blind-placebo-controlled-trial
#4
Reihaneh Hajizadeh-Zaker, Alireza Ghajar, Bita Mesgarpour, Mohsen Afarideh, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: This study aimed at investigating the efficacy and tolerability of l-carnosine as an add-on to risperidone in the management of children with autism. METHODS: This was a 10-week, randomized, double-blind, placebo-controlled study. Seventy drug-free children aged 4-12 years old with a diagnosis of autism spectrum disorder (ASD), according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (DSM-5) who had an Aberrant Behavior Checklist-Community (ABC-C) scale irritability subscale score of ≥12, entered the study...
October 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29027752/label-free-multiplex-dna-detection-utilizing-projected-capacitive-touchscreen
#5
Joon Young Lee, Byoung Yeon Won, Hyun Gyu Park
We have developed a novel strategy to achieve label-free multiplex DNA detection system based on the projected capacitive touchscreen. Touchscreen panel was first fabricated by patterning the ITO (indium-tin-oxide) electrode array on the glass wafer, and the electrodes were modified with the respective capture probe DNA sequences complementary to hemagglutinin1 (H1), neuraminidase1 (N1), and matrix1 (M1) DNA to demonstrate the molecular diagnosis of H1N1 influenza virus as a model pathogen. DNA sample was then applied to the electrodes to allow hybridization of target DNA with the corresponding complementary capture probe...
October 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29027395/prognostic-value-of-programmed-death-ligand-1-pd-l1-expression-in-ovarian-clear-cell-carcinoma
#6
Jun Zhu, Hao Wen, Rui Bi, Yong Wu, Xiaohua Wu
OBJECTIVE: Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and its correlation with clinicopathologic features and clinical outcomes in ovarian clear cell carcinoma (OCCC). METHODS: The PD-L1 expression was measured by tissue-microarray-based immunohistochemistry from 122 eligible patients diagnosed with OCCC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027378/why-is-african-swine-fever-still-present-in-sardinia
#7
C Jurado, E Fernández-Carrión, L Mur, S Rolesu, A Laddomada, J M Sánchez-Vizcaíno
African swine fever (ASF) is an infectious disease of swine that has been present in Sardinia since 1978. Soon after introduction of the disease, several control and eradication programmes were established with limited success. Some researchers attributed the persistence of the disease in central and eastern areas to certain socio-economic factors, the existence of some local and traditional farming practices (i.e., unregistered free-ranging pigs known as brado animals) and the high density of wild boar in the region...
October 12, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29027306/fenton-reaction-induced-renal-carcinogenesis-in-mutyh-deficient-mice-exhibits-less-chromosomal-aberrations-than-the-rat-model
#8
Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26...
October 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29027138/recurrence-of-optimally-treated-malignant-peritoneal-mesothelioma-with-cytoreduction-and-heated-intraperitoneal-chemotherapy
#9
Danielle R Heller, Cody Chiuzan, Robert N Taub, Joshua C Leinwand, Allison M Greene, Gleneara E Bates, John A Chabot, Michael D Kluger
BACKGROUND: The prognosis for patients with diffuse malignant peritoneal mesothelioma has dramatically improved with cytoreductive surgery and intraperitoneal chemotherapy. Little is known about disease recurrence after treatment. We analyzed the time to and predictors of recurrence in a large cohort of optimally treated patients. METHODS: We examined 113 patients completing a two-stage cytoreduction and intraperitoneal chemotherapy protocol. All patients achieved optimal surgical resection with completeness of cytoreduction (CC) score ≤ 1 and were divided into two groups based on absence (Group A) or presence (Group B) of gross disease at the outset of the second operation...
October 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29026678/statistical-model-for-oct-image-denoising
#10
Muxingzi Li, Ramzi Idoughi, Biswarup Choudhury, Wolfgang Heidrich
Optical coherence tomography (OCT) is a non-invasive technique with a large array of applications in clinical imaging and biological tissue visualization. However, the presence of speckle noise affects the analysis of OCT images and their diagnostic utility. In this article, we introduce a new OCT denoising algorithm. The proposed method is founded on a numerical optimization framework based on maximum-a-posteriori estimate of the noise-free OCT image. It combines a novel speckle noise model, derived from local statistics of empirical spectral domain OCT (SD-OCT) data, with a Huber variant of total variation regularization for edge preservation...
September 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29026390/renal-histoarchitectural-changes-in-nevirapine-therapy-possible-role-of-kolaviron-and-vitamin-c-in-an-experimental-animal-model
#11
Ugochukwu Offor, Sunday Adelaja Ajayi, Isaac Ayoola Jegede, Salem Kharwa, Edwin Coleridge Naidu, Onyemaechi Okpara Azu
BACKGROUND: There is paucity of literature regarding the nephrotoxicity of antiretroviral drugs and its interaction with plant-based adjuvants. This study investigates the attenuating effect of kolaviron in nevirapine-therapy on the histological structure of the kidneys of adult male Sprague-Dawley rats. OBJECTIVE: To determine the attenuating influence of anti-oxidant status of kolaviron on the kidneys of experimental animals following nevirapine administration...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29023120/dft-study-on-the-formation-mechanism-of-normal-and-abnormal-n-heterocyclic-carbene-carbon-dioxide-adducts-from-the-reaction-of-an-imidazolium-based-ionic-liquid-with-co2
#12
Mengmeng Dong, Jun Gao, Chengbu Liu, Dongju Zhang
To illustrate the formation mechanism of normal and abnormal N-heterocyclic carbene-carbon dioxide adducts (NHC-CO2 and aNHC-CO2), we implement DFT calculations on the reactions of two imidazolium-based ionic liquids ([C2C1Im][OAc] and [C2C1Im][CH3SO3]) with CO2. The reaction of [C2C1Im][OAc] with CO2 is mimicked using the gas phase model, implicit solvent model, and combined explicit-implicit solvent model. In gas phase, the calculated barrier at 125℃ and 10 MPa is 12.1 kcal/mol for the formation of NHC-CO2 and 22...
October 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29022636/the-effect-of-anthocyanins-from-red-wine-and-blackberry-on-the-integrity-of-a-keratinocyte-model-using-ecis
#13
Ana Évora, Victor de Freitas, Nuno Mateus, Iva Fernandes
There is a growing market demand for the incorporation of plant-derived ingredients into new products for the cosmetic industry. Anthocyanins are polyphenols arising from plant secondary metabolism that have been shown to possess many bioactive properties such as free radical scavenging, antimicrobial, and chemopreventive activities. In this work, the biological activities of red wine and blackberry anthocyanins were assessed by developing a new keratinocyte barrier model using the HaCat cell line and a microelectrode-based biosensor device, referred to as Electric Cell-Substrate Impedance Sensing (ECIS)...
October 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29022516/folk-economic-beliefs-an-evolutionary-cognitive-model
#14
Pascal Boyer, Michael Bang Petersen
The domain of "folk-economics" consists in explicit beliefs about the economy held by laypeople, untrained in economics, about such topics as e.g., the causes of the wealth of nations, the benefits or drawbacks of markets and international trade, the effects of regulation, the origins of inequality, the connection between work and wages, the economic consequences of immigration, or the possible causes of unemployment. These beliefs are crucial in forming people's political beliefs, and in shaping their reception of different policies...
October 12, 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/29022143/comorbidity-of-gastrointestinal-disorders-migraine-and-tension-type-headache-a-cross-sectional-study-in-iran
#15
Fahimeh Martami, Zeinab Ghorbani, Maryam Abolhasani, Mansoureh Togha, Alipasha Meysamie, Alireza Sharifi, Soodeh Razeghi Jahromi
Migraine can be accompanied by some gastrointestinal (GI) disorders. In this study, we aimed to investigate the relationship between migraine and tension-type headache (TTH) and different lower and upper GI disorders as well as non-alcoholic fatty liver (NAFLD) and cholelithiasis. This cross-sectional study included 1574 overweight and obese participants who were referred to the Obesity Research Center of Sina Hospital, Tehran, Iran. The diagnosis of migraine and TTH was made by an expert neurologist based on the international classification of headache disorders-III β (ICHD III β)...
October 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29022084/exposure-response-analyses-of-trastuzumab-emtansine-in-patients-with-her2-positive-advanced-breast-cancer-previously-treated-with-trastuzumab-and-a-taxane
#16
Chunze Li, Bei Wang, Shang-Chiung Chen, Russell Wada, Dan Lu, Xin Wang, Daniel Polhamus, Jonathan French, Shweta Vadhavkar, Alexander Strasak, Melanie Smitt, Amita Joshi, Meghna Samant, Angelica Quartino, Jin Jin, Sandhya Girish
PURPOSE: In the phase III EMILIA study, trastuzumab emtansine (T-DM1) significantly improved progression-free survival (PFS) and overall survival (OS) versus capecitabine plus lapatinib (control) in previously treated human epidermal growth factor receptor 2-positive advanced breast cancer. Using EMILIA data, we evaluated the T-DM1 exposure-response relationship. METHODS: Exposure-response relationships were examined with four exposure metrics [model-predicted and observed minimum concentration (C min) and area under the concentration-time curve from time zero to day 21 of T-DM1 at cycle 1] and multiple efficacy (OS, PFS, objective response rate) and safety (grade ≥ 3 adverse events, grade ≥ 3 thrombocytopenia, grade ≥ 3 hepatotoxicity) endpoints...
October 11, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29021814/sex-specific-association-between-fibroblast-growth-factor-21-and-type-2-diabetes-a-nested-case-control-study-in-singapore-chinese-men-and-women
#17
Yeli Wang, Woon-Puay Koh, Jian-Min Yuan, An Pan
BACKGROUND: Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between FGF-21 and diabetes risk. However, no study has examined whether the association differed by sex, which has been reported between FGF-21 and atherosclerosis. Therefore, we prospectively evaluated the sex-specific association between FGF-21 and diabetes in a Chinese population...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29021136/distinct-angiogenic-changes-during-carcinogenesis-defined-by-novel-label-free-dark-field-imaging-in-a-hamster-cheek-pouch-model
#18
Fangyao Hu, Hannah Martin, Amy Frees Martinez, Jeffrey Everitt, Alaattin Erkanli, Walter T Lee, Mark W Dewhirst, Nirmala Ramanujam
There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark field microscopy of a DMBA-induced hamster cheek pouch model of oral squamous cell carcinoma (SCC). Wavelength-dependent imaging revealed distinct vascular features at different imaging depths and vessel sizes. Vascular tortuosity increased significantly in high-risk lesions, while diameter decreased significantly in hyperplastic and SCC lesions. Large vessels preserved the same trends seen in the original images, whereas small vessels displayed different trends, with length and diameter increasing during carcinogenesis...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29021127/fall-detection-in-individuals-with-lower-limb-amputations-using-mobile-phones-machine-learning-enhances-robustness-for-real-world-applications
#19
Nicholas Shawen, Luca Lonini, Chaithanya Krishna Mummidisetty, Ilona Shparii, Mark V Albert, Konrad Kording, Arun Jayaraman
BACKGROUND: Automatically detecting falls with mobile phones provides an opportunity for rapid response to injuries and better knowledge of what precipitated the fall and its consequences. This is beneficial for populations that are prone to falling, such as people with lower limb amputations. Prior studies have focused on fall detection in able-bodied individuals using data from a laboratory setting. Such approaches may provide a limited ability to detect falls in amputees and in real-world scenarios...
October 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29021117/there-is-an-app-for-that-or-is-there-a-content-analysis-of-publicly-available-smartphone-apps-for-managing-alcohol-use
#20
Bettina B Hoeppner, Melissa R Schick, Lourah M Kelly, Susanne S Hoeppner, Brandon Bergman, John F Kelly
INTRODUCTION: Smartphone apps are emerging as a promising tool to support recovery from and prevention of problematic alcohol use, yet it is unclear what type of apps are currently available in the public domain, and to what degree these apps use interactive tailoring or other dynamic features to meet users' specific needs. METHODS: We conducted a content analysis of Android apps for managing drinking available on Google Play (n=266), downloaded between November 21, 2014 and June 25, 2015...
November 2017: Journal of Substance Abuse Treatment
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