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https://www.readbyqxmd.com/read/27921189/homogenized-constrained-mixture-models-for-anisotropic-volumetric-growth-and-remodeling
#1
F A Braeu, A Seitz, R C Aydin, C J Cyron
Constrained mixture models for soft tissue growth and remodeling have attracted increasing attention over the last decade. They can capture the effects of the simultaneous presence of multiple constituents that are continuously deposited and degraded at in general different rates, which is important to understand essential features of living soft tissues that cannot be captured by simple kinematic growth models. Recently the novel concept of homogenized constrained mixture models was introduced. It was shown that these models produce results which are very similar (and in certain limit cases even identical) to the ones of constrained mixture models based on multi-network theory...
December 5, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27920536/evaluation-of-potential-novel-variations-and-their-interactions-related-to-bipolar-disorders-analysis-of-genome-wide-association-study-data
#2
Cengizhan Acikel, Yesim Aydin Son, Cemil Celik, Husamettin Gul
BACKGROUND: Multifactor dimensionality reduction (MDR) is a nonparametric approach that can be used to detect relevant interactions between single-nucleotide polymorphisms (SNPs). The aim of this study was to build the best genomic model based on SNP associations and to identify candidate polymorphisms that are the underlying molecular basis of the bipolar disorders. METHODS: This study was performed on Whole-Genome Association Study of Bipolar Disorder (dbGaP [database of Genotypes and Phenotypes] study accession number: phs000017...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27920305/projections-of-dental-care-use-through-2026-preventive-care-to-increase-while-treatment-will-decline
#3
Chad D Meyerhoefer, Irina Panovska, Richard J Manski
This study provides a forward-thinking assessment of the factors likely to affect future trends in dental care in the United States. We developed a forecasting model based on historical data from the Medical Expenditure Panel Survey to determine how demographic trends and recent health care policies will affect dental care use in the future. Our forecasts suggest that the medical and dental insurance reforms instituted under the Affordable Care Act will increase rates of dental care use and the number of dental visits, with utilization rates reaching 47 percent in 2026 and the number of visits reaching 334 million, under optimistic assumptions about take-up of pediatric dental coverage...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27919745/biomechanics-of-cell-reorientation-in-a-three-dimensional-matrix-under-compression
#4
Lijie Yang, Léolène Jean Carrington, Begum Erdogan, Mingfang Ao, Bryson M Brewer, Donna J Webb, Deyu Li
Although a number of studies have reported that cells cultured on a stretchable substrate align away from or perpendicular to the stretch direction, how cells sense and respond to compression in a three-dimensional (3D) matrix remains an open question. We analyzed the reorientation of human prostatic normal tissue fibroblasts (NAFs) and cancer-associated fibroblasts (CAFs) in response to 3D compression using a Fast Fourier Transform (FFT) method. Results show that NAFs align to specific angles upon compression while CAFs exhibit a random distribution...
December 2, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27919712/extracts-from-two-ubiquitous-mediterranean-plants-ameliorate-cellular-and-animal-models-of-neurodegenerative-proteinopathies
#5
Michelle Briffa, Stephanie Ghio, Johanna Neuner, Alison J Gauci, Rebecca Cacciottolo, Christelle Marchal, Mario Caruana, Christophe Cullin, Neville Vassallo, Ruben J Cauchi
A signature feature of age-related neurodegenerative proteinopathies is the misfolding and aggregation of proteins, typically amyloid-β (Aβ) in Alzheimer's disease (AD) and α-synuclein (α-syn) in Parkinson's disease (PD), into soluble oligomeric structures that are highly neurotoxic. Cellular and animal models that faithfully replicate the hallmark features of these disorders are being increasing exploited to identify disease-modifying compounds. Natural compounds have been identified as a useful source of bioactive molecules with promising neuroprotective capabilities...
December 2, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27919292/cost-effectiveness-of-screening-for-ovarian-cancer-amongst-postmenopausal-women-a-model-based-economic-evaluation
#6
Ben Kearns, Jim Chilcott, Sophie Whyte, Louise Preston, Susi Sadler
BACKGROUND: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) was the biggest ovarian cancer screening trial to date. A non-significant effect of screening on ovarian cancer was reported, but the authors noted a potential delayed effect of screening, and suggested the need for four years further follow-up. There are no UK-based cost-effectiveness analyses of ovarian cancer screening. Hence we assessed the lifetime outcomes associated with, and the cost-effectiveness of, screening for ovarian cancer in the UK, along with the value of further research...
December 6, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27918594/real-time-reliability-verification-for-uav-flight-control-system-supporting-airworthiness-certification
#7
Haiyang Xu, Ping Wang
In order to verify the real-time reliability of unmanned aerial vehicle (UAV) flight control system and comply with the airworthiness certification standard, we proposed a model-based integration framework for modeling and verification of time property. Combining with the advantages of MARTE, this framework uses class diagram to create the static model of software system, and utilizes state chart to create the dynamic model. In term of the defined transformation rules, the MARTE model could be transformed to formal integrated model, and the different part of the model could also be verified by using existing formal tools...
2016: PloS One
https://www.readbyqxmd.com/read/27917882/parity-deformed-jaynes-cummings-model-robust-maximally-entangled-states
#8
A Dehghani, B Mojaveri, S Shirin, S Amiri Faseghandis
The parity-deformations of the quantum harmonic oscillator are used to describe the generalized Jaynes-Cummings model based on the λ-analog of the Heisenberg algebra. The behavior is interestingly that of a coupled system comprising a two-level atom and a cavity field assisted by a continuous external classical field. The dynamical characters of the system is explored under the influence of the external field. In particular, we analytically study the generation of robust and maximally entangled states formed by a two-level atom trapped in a lossy cavity interacting with an external centrifugal field...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917146/a-unified-theoretical-framework-for-cognitive-sequencing
#9
Tejas Savalia, Anuj Shukla, Raju S Bapi
The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit vs. explicit and goal-directed vs. habits. We propose a theoretical framework unifying these two streams...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27916944/trend-residual-dual-modeling-for-detection-of-outliers-in-low-cost-gps-trajectories
#10
Xiaojian Chen, Tingting Cui, Jianhong Fu, Jianwei Peng, Jie Shan
Low-cost GPS (receiver) has become a ubiquitous and integral part of our daily life. Despite noticeable advantages such as being cheap, small, light, and easy to use, its limited positioning accuracy devalues and hampers its wide applications for reliable mapping and analysis. Two conventional techniques to remove outliers in a GPS trajectory are thresholding and Kalman-based methods, which are difficult in selecting appropriate thresholds and modeling the trajectories. Moreover, they are insensitive to medium and small outliers, especially for low-sample-rate trajectories...
December 1, 2016: Sensors
https://www.readbyqxmd.com/read/27915181/bioenergy-and-biodiversity-intensified-biomass-extraction-from-hedges-impairs-habitat-conditions-for-birds
#11
Ralf Sauerbrei, Birgit Aue, Christian Krippes, Eva Diehl, Volkmar Wolters
Biomass is increasingly used as an alternative source for energy in Europe. Woody material cut from hedges is considered to provide a suitable complement to maize and oilseed rape, which are currently the dominant biomass sources. Since shrubs and trees are also important habitats for birds, however, coppicing of hedges at the landscape scale may adversely affect the diversity of the avifauna. To evaluate this risk, we estimated the response of hedge birds to three management scenarios differing in cutting intensity and hedge selection...
December 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27915136/dynamics-of-two-interacting-bubbles-in-a-nonspherical-ultrasound-field
#12
Jinfu Liang, Xun Wang, Jing Yang, Lunxun Gong
In this paper, we present and analyze a model of the oscillations of a pair of gas bubbles driven by nonspherical ultrasound. We derived our model based on the perturbation and potential flow theories and use it to study three cases of oscillation of two bubbles under driving ultrasound with different initial phases, different separation distances between the bubbles and different sound pressure amplitudes. For the driving ultrasound with different initial phases, we obtain the in-phase and anti-phase radial pulsations of the bubbles in incompressible liquid...
November 22, 2016: Ultrasonics
https://www.readbyqxmd.com/read/27914639/actual-et-modelling-based-on-the-budyko-framework-and-the-sustainability-of-vegetation-water-use-in-the-loess-plateau
#13
Xuerui Gao, Miao Sun, Qi Zhao, Pute Wu, Xining Zhao, Wenxiang Pan, Yubao Wang
Jointly influenced by the natural factors and the artificial protection measures, the ecological environment of Loess Plateau has been significantly improved in recent years, but which has already brought about some water-related problems. To maintain the balance between precipitation and water consumption is an important foundation for sustainable development of the ecology remediation. This study used Budyko Framework to simulate the actual water consumption of 161 sub-basins from 1990 to 2014. Based on the simulation results, the research also analyzed the evolution characteristics of water balance in Loess Plateau from 1990 to 2014...
November 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27914442/analysis-and-modeling-of-255-source-levels-of-merchant-ships-from-an-acoustic-observatory-along-st-lawrence-seaway
#14
Yvan Simard, Nathalie Roy, Cédric Gervaise, Samuel Giard
An ensemble of 255 spectral source levels (SSLs) of merchant ships were measured with an opportunistic seaway acoustic observatory adhering to the American National Standards Institute/Acoustical Society of America S12.64-2009 standard as much as possible, and deployed in the 350-m deep lower St. Lawrence Seaway in eastern Canada. The estimated SSLs were sensitive to the transmission loss model. The best transmission loss model at the three measuring depths was an empirical in situ function for ranges larger than 300 m, fused with estimates from a wavenumber integration propagation model fed with inverted local geoacoustic properties for [300 to 1 m] ranges...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914076/reconstructing-the-ancestral-relationships-between-bacterial-pathogen-genomes
#15
Caitlin Collins, Xavier Didelot
Following recent developments in DNA sequencing technology, it is now possible to sequence hundreds of whole genomes from bacterial isolates at relatively low cost. Analyzing this growing wealth of genomic data in terms of ancestral relationships can reveal many interesting aspects of the evolution, ecology, and epidemiology of bacterial pathogens. However, reconstructing the ancestry of a sample of bacteria remains challenging, especially for the majority of species where recombination is frequent. Here, we review and describe the computational techniques currently available to infer ancestral relationships, including phylogenetic methods that either ignore or account for the effect of recombination, as well as model-based and model-free phylogeny-independent approaches...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913961/prediction-of-postoperative-clinical-recovery-of-drop-foot-attributable-to-lumbar-degenerative-diseases-via-a-bayesian-network
#16
Shota Takenaka, Hiroyuki Aono
BACKGROUND: Drop foot resulting from degenerative lumbar diseases can impair activities of daily living. Therefore, predictors of recovery of this symptom have been investigated using univariate or/and multivariate analyses. However, the conclusions have been somewhat controversial. Bayesian network models, which are graphic and intuitive to the clinician, may facilitate understanding of the prognosis of drop foot resulting from degenerative lumbar diseases. QUESTIONS/PURPOSES: (1) To show a layered correlation among predictors of recovery from drop foot resulting from degenerative lumbar diseases; and (2) to develop support tools for clinical decisions to treat drop foot resulting from lumbar degenerative diseases...
December 2, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27913364/an-intelligible-risk-stratification-model-based-on-pairwise-and-size-constrained-kmeans
#17
Longfei Han, Senlin Luo, Huaiqing Wang, Limin Pan, Xincheng Ma, Tiemei Zhang
Having a system to stratify individuals according to risk is key to clinical disease prevention, this allows individuals identified at different risk tiers benefit from further investigation and intervention. But the same risk score estimated for two different persons doesn't mean they need the same further investigation or represent the similarity health condition between two persons. Meanwhile, users still does not know a prior what most of the risk tiers are, and how many tiers should be found in risk stratification...
November 29, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27912740/effectiveness-and-cost-effectiveness-of-an-in-home-respite-care-program-in-supporting-informal-caregivers-of-people-with-dementia-design-of-a-comparative-study
#18
Sophie Vandepitte, Nele Van Den Noortgate, Koen Putman, Sofie Verhaeghe, Lieven Annemans
BACKGROUND: Frequent hospitalization and permanent nursing home placement not only affect the well-being of persons with dementia, but also place great financial strain on society. Therefore, it is important to create effective strategies to support informal caregivers so that they can continue to perform their demanding role. Preliminary qualitative evidence suggests that community-based respite services can actually be important for caregivers, and that the level of evidence should be further established in terms of effectiveness...
December 2, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27911939/a-new-model-for-solving-time-cost-quality-trade-off-problems-in-construction
#19
Fang Fu, Tao Zhang
A poor quality affects project makespan and its total costs negatively, but it can be recovered by repair works during construction. We construct a new non-linear programming model based on the classic multi-mode resource constrained project scheduling problem considering repair works. In order to obtain satisfactory quality without a high increase of project cost, the objective is to minimize total quality cost which consists of the prevention cost and failure cost according to Quality-Cost Analysis. A binary dependent normal distribution function is adopted to describe the activity quality; Cumulative quality is defined to determine whether to initiate repair works, according to the different relationships among activity qualities, namely, the coordinative and precedence relationship...
2016: PloS One
https://www.readbyqxmd.com/read/27911562/macroscopic-model-for-head-on-binary-droplet-collisions-in-a-gaseous-medium
#20
Jie Li
In this Letter, coalescence-bouncing transitions of head-on binary droplet collisions are predicted by a novel macroscopic model based entirely on fundamental laws of physics. By making use of the lubrication theory of Zhang and Law [Phys. Fluids 23, 042102 (2011)], we have modified the Navier-Stokes equations to accurately account for the rarefied nature of the interdroplet gas film. Through the disjoint pressure model, we have incorporated the intermolecular van der Waals forces. Our model does not use any adjustable (empirical) parameters...
November 18, 2016: Physical Review Letters
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