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https://www.readbyqxmd.com/read/28938599/a-pathways-based-prediction-model-for-classifying-breast-cancer-subtypes
#1
Tong Wu, Yunfeng Wang, Ronghui Jiang, Xinliang Lu, Jiawei Tian
Breast cancer is highly heterogeneous and is classified into four subtypes characterized by specific biological traits, treatment responses, and clinical prognoses. We performed a systemic analysis of 698 breast cancer patient samples from The Cancer Genome Atlas project database. We identified 136 breast cancer genes differentially expressed among the four subtypes. Based on unsupervised clustering analysis, these 136 core genes efficiently categorized breast cancer patients into the appropriate subtypes. Functional enrichment based on Kyoto Encyclopedia of Genes and Genomes analysis identified six functional pathways regulated by these genes: JAK-STAT signaling, basal cell carcinoma, inflammatory mediator regulation of TRP channels, non-small cell lung cancer, glutamatergic synapse, and amyotrophic lateral sclerosis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937930/feasibility-of-a-multidisciplinary-caregiving-training-protocol-for-young-caregivers-in-families-with-als
#2
Melinda S Kavanaugh, Megan Howard, Lori Banker-Horner
Feasibility of a multidisciplinary caregiving training protocol for young caregivers in families with ALS. OBJECTIVES: To assess the feasibility of a multidisciplinary young caregiver group training protocol for children and youth who provide care to a family member with ALS. METHOD: Peer group experiential young caregiver model based on theories of self-management and self-efficacy. Training conducted by a multidisciplinary team of therapists in ALS (PT, OT, Speech and social work), as well as assistive device vendors...
September 22, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28937298/probing-the-toxicity-of-nanoparticles-a-unified-in-silico-machine-learning-model-based-on-perturbation-theory
#3
Riccardo Concu, Valeria V Kleandrova, Alejandro Speck-Planche, M Natália D S Cordeiro
Nanoparticles (NPs) are part of our daily life, having a wide range of applications in engineering, physics, chemistry, and biomedicine. However, there are serious concerns regarding the harmful effects that NPs can cause to the different biological systems and their ecosystems. Toxicity testing is an essential step for assessing the potential risks of the NPs, but the experimental assays are often very expensive and usually too slow to flag the number of NPs that may cause adverse effects. In silico models centered on quantitative structure-activity/toxicity relationships (QSAR/QSTR) are alternative tools that have become valuable supports to risk assessment, rationalizing the search for safer NPs...
September 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28937117/gender-differences-in-dental-students-professional-expectations-and-attitudes-a-qualitative-study
#4
M da Graça Kfouri, S T Moysés, M C L Gabardo, S J Moysés
Introduction With the significant increase of women in dentistry, the profile of the dental professional has been altered.Aim To investigate the discourses of future dental surgeons, of both genders, from public and private universities of Curitiba, Paraná, Brazil, to detect whether gender profile differences can influence training and intended future practice.Methods The problem is approached using a qualitative design, with the strategy of collective interviews in focus groups followed by a discourse analysis...
September 22, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28936755/comparison-of-control-strategies-for-single-stage-partial-nitrification-anammox-granular-sludge-reactor-for-mainstream-sewage-treatment-a-model-based-evaluation
#5
Jun Wu
The low ammonium concentration, low temperature, presence of organic matter, and large variation of influent ammonium load pose serious challenges for the application of PN/AMX (partial nitrification-anammox) reactor in the mainstream wastewater treatment. Previous mathematical simulation studies of PN/AMX granule reactor mainly concentrated on the steady-state modeling. The steady-state simulation cannot be used for developing control strategies under dynamic condition. In this study, four control strategies were evaluated on their abilities to minimize the impact of feed disturbances on autotrophic nitrogen removal in mainstream wastewater...
September 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28936368/uncertainty-quantified-computational-analysis-of-the-energetics-of-virus-capsid-assembly
#6
N Clement, M Rasheed, C Bajaj
Most of the existing research in assembly pathway prediction/analysis of viral capsids makes the simplifying assumption that the configuration of the intermediate states can be extracted directly from the final configuration of the entire capsid. This assumption does not take into account the conformational changes of the constituent proteins as well as minor changes to the binding interfaces that continue throughout the assembly process until stabilization. This paper presents a statistical-ensemble based approach which samples the configurational space for each monomer with the relative local orientation between monomers, to capture the uncertainties in binding and conformations...
December 2016: Proceedings
https://www.readbyqxmd.com/read/28936134/cost-effectiveness-of-an-intervention-focused-on-reducing-bathing-disability
#7
Magnus Zingmark, Ingeborg Nilsson, Fredrik Norström, Klas Göran Sahlén, Lars Lindholm
The onset of bathing disability among older people is critical for a decline in functioning and has implications for both the individuals' quality of life and societal costs. The aim of this study was to evaluate long-term cost effectiveness of an intervention targeting bathing disability among older people. For hypothetical cohorts of community-dwelling older people with bathing disability, transitions between states of dependency and death were modelled over 8 years including societal costs. A five-state Markov model based on states of dependency was used to evaluate Quality-adjusted life years (QALYs) and costs from a societal perspective...
September 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28935983/model-based-vascular-elastography-improves-the-detection-of-flow-induced-carotid-artery-remodeling-in-mice
#8
Vyacheslav A Korshunov, Hexuan Wang, Rifat Ahmed, Deanne M Mickelsen, Qian Zhou, Chen Yan, Marvin M Doyley
Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935720/suppression-of-store-operated-ca-2-entry-by-activation-of-gper-contribution-to-a-clamping-effect-on-endothelial-ca-2-signaling
#9
Lara E Terry, Mark VerMeer, Jennifer Giles, Quang-Kim Tran
The G Protein-coupled Estrogen Receptor 1 (GPER, formerly a.k.a. GPR30) modulates many Ca(2+)-dependent activities in endothelial cells. However, the underlying mechanisms are poorly understood. We recently reported that GPER acts to prolong cytoplasmic Ca(2+) signals by interacting with and promoting inhibitory phosphorylation of the plasma membrane Ca(2+)-ATPase. In this study, we examined the role of GPER activation in modulating store-operated Ca(2+) entry (SOCE) via effects on the Stromal Interaction Molecule 1 (STIM1)...
September 21, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28935598/infection-dynamics-of-a-v-%C3%A2-splendidus-strain-pathogenic-to-mytilus-edulis-in%C3%A2-vivo-and-in%C3%A2-vitro-interactions-with-hemocytes
#10
Yosra Ben Cheikh, Marie-Agnès Travers, Frank Le Foll
The pathogenic strain V. splendidus 10/068 1T1 has previously been reported for its virulence to the blue mussel and for its capacity to alter immune responses. In this study, we expanded the knowledge on hemocyte-pathogen interactions by using in vitro and in vivo assays. V. splendidus 10/068 1T1 severely inhibited cell adhesion and acidic vacuole formation unlike the innocuous phylogenetically related V. splendidus 12/056 M24T1 which had no effect on these cell functions. Furthermore, the virulent bacteria decreased hemocyte viability (59% of viability after 24 h)...
September 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28935463/image-guidance-for-transcatheter-aortic-valve-implantation-tavi-and-cerebral-embolic-protection
#11
I Vernikouskaya, W Rottbauer, B Gonska, C Rodewald, J Seeger, V Rasche, J Wöhrle
The study was aimed at evaluation of the feasibility and potential benefit of image fusion (IF) of pre-procedural CT angiography (CTA) and x-ray (XR) fluoroscopy for image-guided navigation in transfemoral transcatheter aortic valve implantation (TAVI) with the strong focus on guiding the double-filter cerebral embolic protection device and valve prosthesis placement. METHODS: In 31 patients undergoing TAVI, image registration of CTA-derived 3D anatomical models of the relevant cardiac anatomy and vasculature, and live XR was performed applying a commercially available navigation tool...
September 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28934849/nanospecific-phytotoxicity-of-cuo-nanoparticles-in-soils-disappeared-when-bioavailability-factors-were-considered
#12
Hao Qiu, Erik Smolders
Bioavailability-modifying factors such as soil type and aging have only rarely been considered in assessing toxicity of metal-containing nanoparticles in soil. Here, we examined the toxicity to barley (Hordeum vulgare) of CuO nanoparticles (CuO-NPs) relative to CuO bulk particles (CuO-BPs) and Cu acetate (Cu(OAc)2) in six different soils with or without aging. The set up allows identifying whether or not NPs-derived colloidal Cu in soil porewater contributes to toxicity. Ultrafiltration (50 kDa) was performed together with geochemical modeling to determine {Cu2+} (free Cu2+ activity in soil porewater)...
September 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28934644/cyriax-s-deep-friction-massage-application-parameters-evidence-from-a-cross-sectional-study-with-physiotherapists
#13
Paula Chaves, Daniela Simões, Maria Paço, Francisco Pinho, José Alberto Duarte, Fernando Ribeiro
BACKGROUND: Deep friction massage is one of several physiotherapy interventions suggested for the management of tendinopathy. OBJECTIVES: To determine the prevalence of deep friction massage use in clinical practice, to characterize the application parameters used by physiotherapists, and to identify empirical model-based patterns of deep friction massage application in degenerative tendinopathy. DESIGN: observational, analytical, cross-sectional and national web-based survey...
September 14, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28934616/a-model-based-bayesian-solution-for-characterization-of-complex-damage-scenarios-in-aerospace-composite-structures
#14
H Reed, Cara A C Leckey, A Dick, G Harvey, J Dobson
Ultrasonic damage detection and characterization is commonly used in nondestructive evaluation (NDE) of aerospace composite components. In recent years there has been an increased development of guided wave based methods. In real materials and structures, these dispersive waves result in complicated behavior in the presence of complex damage scenarios. Model-based characterization methods utilize accurate three dimensional finite element models (FEMs) of guided wave interaction with realistic damage scenarios to aid in defect identification and classification...
September 5, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28934523/sleep-stage-transition-dynamics-reveal-specific-stage-2-vulnerability-in-insomnia
#15
Yishul Wei, Michele A Colombo, Jennifer R Ramautar, Tessa F Blanken, Ysbrand D van der Werf, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Eus J W Van Someren
Study Objectives: Objective sleep impairments in insomnia disorder (ID) are insufficiently understood. The present study evaluated whether whole-night sleep stage dynamics derived from polysomnography (PSG) differ between people with ID and matched controls and whether sleep stage dynamic features discriminate them better than conventional sleep parameters. Methods: Eighty-eight participants aged 21-70 years, including 46 with ID and 42 age- and sex-matched controls without sleep complaints, were recruited through www...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934501/model-based-design-of-rna-hybridization-networks-implemented-in-living-cells
#16
Guillermo Rodrigo, Satya Prakash, Shensi Shen, Eszter Majer, José-Antonio Daròs, Alfonso Jaramillo
Synthetic gene circuits allow the behavior of living cells to be reprogrammed, and non-coding small RNAs (sRNAs) are increasingly being used as programmable regulators of gene expression. However, sRNAs (natural or synthetic) are generally used to regulate single target genes, while complex dynamic behaviors would require networks of sRNAs regulating each other. Here, we report a strategy for implementing such networks that exploits hybridization reactions carried out exclusively by multifaceted sRNAs that are both targets of and triggers for other sRNAs...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934291/emotional-metacontrol-of-attention-top-down-modulation-of-sensorimotor-processes-in-a-robotic-visual-search-task
#17
Marwen Belkaid, Nicolas Cuperlier, Philippe Gaussier
Emotions play a significant role in internal regulatory processes. In this paper, we advocate four key ideas. First, novelty detection can be grounded in the sensorimotor experience and allow higher order appraisal. Second, cognitive processes, such as those involved in self-assessment, influence emotional states by eliciting affects like boredom and frustration. Third, emotional processes such as those triggered by self-assessment influence attentional processes. Last, close emotion-cognition interactions implement an efficient feedback loop for the purpose of top-down behavior regulation...
2017: PloS One
https://www.readbyqxmd.com/read/28934274/desert-soil-clay-content-estimation-using-reflectance-spectroscopy-preprocessed-by-fractional-derivative
#18
Jingzhe Wang, Tashpolat Tiyip, Jianli Ding, Dong Zhang, Wei Liu, Fei Wang, Nigara Tashpolat
Effective pretreatment of spectral reflectance is vital to model accuracy in soil parameter estimation. However, the classic integer derivative has some disadvantages, including spectral information loss and the introduction of high-frequency noise. In this paper, the fractional order derivative algorithm was applied to the pretreatment and partial least squares regression (PLSR) was used to assess the clay content of desert soils. Overall, 103 soil samples were collected from the Ebinur Lake basin in the Xinjiang Uighur Autonomous Region of China, and used as data sets for calibration and validation...
2017: PloS One
https://www.readbyqxmd.com/read/28934161/improving-the-process-of-adjusting-the-parameters-of-finite-element-models-of-healthy-human-intervertebral-discs-by-the-multi-response-surface-method
#19
Fátima Somovilla Gómez, Rubén Lostado Lorza, Marina Corral Bobadilla, Rubén Escribano García
The kinematic behavior of models that are based on the finite element method (FEM) for modeling the human body depends greatly on an accurate estimate of the parameters that define such models. This task is complex, and any small difference between the actual biomaterial model and the simulation model based on FEM can be amplified enormously in the presence of nonlinearities. The current paper attempts to demonstrate how a combination of the FEM and the MRS methods with desirability functions can be used to obtain the material parameters that are most appropriate for use in defining the behavior of Finite Element (FE) models of the healthy human lumbar intervertebral disc (IVD)...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28933757/the-mechanisms-for-within-host-influenza-virus-control-affect-model-based-assessment-and-prediction-of-antiviral-treatment
#20
Pengxing Cao, James M McCaw
Models of within-host influenza viral dynamics have contributed to an improved understanding of viral dynamics and antiviral effects over the past decade. Existing models can be classified into two broad types based on the mechanism of viral control: models utilising target cell depletion to limit the progress of infection and models which rely on timely activation of innate and adaptive immune responses to control the infection. In this paper, we compare how two exemplar models based on these different mechanisms behave and investigate how the mechanistic difference affects the assessment and prediction of antiviral treatment...
July 26, 2017: Viruses
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