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https://www.readbyqxmd.com/read/29332198/drug-delivery-and-transport-into-the-central-circulation-an-example-of-zero-order-in-vivo-absorption-of-rotigotine-from-a-transdermal-patch-formulation
#1
Willi Cawello, Marina Braun, Jens-Otto Andreas
BACKGROUND AND OBJECTIVE: Pharmacokinetic studies using deconvolution methods and non-compartmental analysis to model clinical absorption of drugs are not well represented in the literature. The purpose of this research was (1) to define the system of equations for description of rotigotine (a dopamine receptor agonist delivered via a transdermal patch) absorption based on a pharmacokinetic model and (2) to describe the kinetics of rotigotine disposition after single and multiple dosing...
January 13, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29331986/sex-differences-in-impact-of-coronary-artery-calcification-to-predict-coronary-artery-disease
#2
Yoko M Nakao, Yoshihiro Miyamoto, Masahiro Higashi, Teruo Noguchi, Mitsuru Ohishi, Isao Kubota, Hiroyuki Tsutsui, Tomohiro Kawasaki, Yutaka Furukawa, Michihiro Yoshimura, Hideaki Morita, Kunihiro Nishimura, Akiko Kada, Yoichi Goto, Tomonori Okamura, Chuwa Tei, Hitonobu Tomoike, Hiroaki Naito, Satoshi Yasuda
OBJECTIVE: To assess sex-specific differences regarding use of conventional risks and coronary artery calcification (CAC) to detect coronary artery disease (CAD) using coronary CT angiography (CCTA). METHODS: The Nationwide Gender-specific Atherosclerosis Determinants Estimation and Ischemic Cardiovascular Disease Prospective Cohort study is a prospective, multicentre, nationwide cohort study. Candidates with suspected CAD aged 50-74 years enrolled from 2008 to 2012...
January 13, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29331892/dynamic-probabilistic-material-flow-analysis-of-nano-sio2-nano-iron-oxides-nano-ceo2-nano-al2o3-and-quantum-dots-in-seven-european-regions
#3
Yan Wang, Bernd Nowack
Static environmental exposure assessment models based on material flow analysis (MFA) have previously been used to estimate flows of engineered nanomaterials (ENMs) to the environment. However, such models do not account for changes in the system behavior over time. Dynamic MFA used in this study includes the time-dependent development of the modelling system by considering accumulation of ENMs in stocks and the environment, and the dynamic release of ENMs from nano-products. In addition, this study also included regional variations in population, waste management systems, and environmental compartments, which subsequently influence the environmental release and concentrations of ENMs...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29331819/new-strategy-for-determination-of-anthocyanins-polyphenols-and-antioxidant-capacity-of-brassica-oleracea-liquid-extract-using-infrared-spectroscopies-and-multivariate-regression
#4
Isadora R N de Oliveira, Jussara V Roque, Mariza P Maia, Paulo C Stringheta, Reinaldo F Teófilo
A new method was developed to determine the antioxidant properties of red cabbage extract (Brassica oleracea) by mid (MID) and near (NIR) infrared spectroscopies and partial least squares (PLS) regression. A 70% (v/v) ethanolic extract of red cabbage was concentrated to 9° Brix and further diluted (12 to 100%) in water. The dilutions were used as external standards for the building of PLS models. For the first time, this strategy was applied for building multivariate regression models. Reference analyses and spectral data were obtained from diluted extracts...
January 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331246/estimation-of-expected-dengue-seroprevalence-from-passive-epidemiological-surveillance-systems-in-selected-areas-of-argentina-a-proxy-to-evaluate-the-applicability-of-dengue-vaccination
#5
Pablo Orellano, Darío Vezzani, Nancy Quaranta, Julieta Reynoso, Oscar Daniel Salomón
BACKGROUND: Current recommendations about dengue vaccination by the World Health Organization depend on seroprevalence levels and serological status in populations and individuals. However, seroprevalence estimation may be difficult due to a diversity of factors. Thus, estimation through models using data from epidemiological surveillance systems could be an alternative procedure to achieve this goal. OBJECTIVE: To estimate the expected dengue seroprevalence in children of selected areas in Argentina, using a simple model based on data from passive epidemiological surveillance systems...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29330704/the-effects-of-coenzyme-q10-supplementation-on-blood-pressures-among-patients-with-metabolic-diseases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Reza Tabrizi, Maryam Akbari, Nasrin Sharifi, Kamran B Lankarani, Mahmood Moosazadeh, Fariba Kolahdooz, Mohsen Taghizadeh, Zatollah Asemi
INTRODUCTION: Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial. AIM: This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases. METHODS: Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched...
January 12, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29330658/patient-specific-model-based-segmentation-of-brain-tumors-in-3d-intraoperative-ultrasound-images
#7
Elisee Ilunga-Mbuyamba, Juan Gabriel Avina-Cervantes, Dirk Lindner, Felix Arlt, Jean Fulbert Ituna-Yudonago, Claire Chalopin
PURPOSE: Intraoperative ultrasound (iUS) imaging is commonly used to support brain tumor operation. The tumor segmentation in the iUS images is a difficult task and still under improvement because of the low signal-to-noise ratio. The success of automatic methods is also limited due to the high noise sensibility. Therefore, an alternative brain tumor segmentation method in 3D-iUS data using a tumor model obtained from magnetic resonance (MR) data for local MR-iUS registration is presented in this paper...
January 12, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29330654/risk-prediction-model-for-severe-postoperative-complication-in-bariatric-surgery
#8
Erik Stenberg, Yang Cao, Eva Szabo, Erik Näslund, Ingmar Näslund, Johan Ottosson
BACKGROUND: Factors associated with risk for adverse outcome are important considerations in the preoperative assessment of patients for bariatric surgery. As yet, prediction models based on preoperative risk factors have not been able to predict adverse outcome sufficiently. OBJECTIVE: This study aimed to identify preoperative risk factors and to construct a risk prediction model based on these. METHODS: Patients who underwent a bariatric surgical procedure in Sweden between 2010 and 2014 were identified from the Scandinavian Obesity Surgery Registry (SOReg)...
January 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29330610/nutrition-delivery-of-a-model-based-icu-glycaemic-control-system
#9
Kent W Stewart, J Geoffrey Chase, Christopher G Pretty, Geoffrey M Shaw
BACKGROUND: Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven difficult. STAR is a proven, effective model-based ICU GC protocol that uniquely maintains normo-glycaemia by changing both insulin and nutrition interventions to maximise nutrition in the context of GC in the 4.4-8.0 mmol/L range. Hence, the level of nutrition it provides is a time-varying estimate of the patient-specific ability to take up glucose...
January 10, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29330204/pazopanib-exposure-relationship-with-clinical-efficacy-and-safety-in-the-adjuvant-treatment-of-advanced-renal-cell-carcinoma
#10
Cora Sternberg, Frede Donskov, Naomi B Haas, Christian Doehn, Paul Russo, Mohamed A Elmeliegy, Guillaume Baneyx, Hiya Banerjee, Paola Aimone, Robert J Motzer
PURPOSE: PROTECT, a phase III randomized placebo-controlled study, evaluated pazopanib efficacy and safety in the adjuvant RCC setting. The relationship between pazopanib exposure (Ctrough) and efficacy and safety was evaluated. EXPERIMENTAL DESIGN: Evaluable steady-state blood trough concentrations were collected from 311 patients at week 3 or 5 (early Ctrough), and 250 patients at week 16 or 20 (late Ctrough). Pazopanib pharmacokinetic (PK) data was analyzed via a population model approach...
January 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29330075/the-epidemic-model-based-on-the-approximation-for-third-order-motifs-on-networks
#11
Jinxian Li, Weiqiang Li, Zhen Jin
The spread of an infectious disease may depend on the structure of the network. To study the influence of the structure parameters of the network on the spread of the epidemic, we need to put these parameters into the epidemic model. The method of moment closure introduces structure parameters into the epidemic model. In this paper, we present a new moment closure epidemic model based on the approximation of third-order motifs in networks. The order of a motif defined in this paper is determined by the number of the edges in the motif, rather than by the number of nodes in the motif as defined in the literature...
January 9, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29329834/heterospectral-two-dimensional-correlation-analysis-with-near-infrared-hyperspectral-imaging-for-monitoring-oxidative-damage-of-pork-myofibrils-during-frozen-storage
#12
Weiwei Cheng, Da-Wen Sun, Hongbin Pu, Qingyi Wei
Near-infrared (NIR) spectra contain abundant data, heterospectral two-dimensional correlation (H2D-CS) analysis offers a good way to interpret these data. For the first time, H2D-CS was used to correlate the NIR hyperspectral imaging (HSI) data with mid-infrared spectra and to identify feature-related wavebands for developing models for monitoring the oxidative damage of pork myofibrils during frozen storage. The HSI images were acquired at frozen state without thawing and the oxidative damage of myofibrils was assessed by carbonyl content...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329732/changes-in-quantitative-ct-image-features-of-ground-glass-nodules-in-differentiating-invasive-pulmonary-adenocarcinoma-from-benign-and-in-situ-lesions-histopathological-comparisons
#13
Y P Zhang, M A Heuvelmans, H Zhang, M Oudkerk, G X Zhang, X Q Xie
AIM: To evaluate progressive changes in quantitative CT features of the non-solid component of ground-glass nodules (GGNs) from baseline to follow-up to differentiate invasive (minimally invasive adenocarcinoma [MIA] and invasive adenocarcinoma [IA]) GGNs from benign or pre-invasive (adenocarcinoma in situ [AIS]) lesions. MATERIALS AND METHODS: Patients with a GGN detected at baseline and follow-up computed tomography (CT), examined by tissue sampling were included in the study...
January 9, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29329349/natural-wind-variability-triggered-drop-in-german-redispatch-volume-and-costs-from-2015-to-2016
#14
Jan Wohland, Mark Reyers, Carolin Märker, Dirk Witthaut
Avoiding dangerous climate change necessitates the decarbonization of electricity systems within the next few decades. In Germany, this decarbonization is based on an increased exploitation of variable renewable electricity sources such as wind and solar power. While system security has remained constantly high, the integration of renewables causes additional costs. In 2015, the costs of grid management saw an all time high of about € 1 billion. Despite the addition of renewable capacity, these costs dropped substantially in 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29329309/time-series-sightability-modeling-of-animal-populations
#15
Althea A ArchMiller, Robert M Dorazio, Katherine St Clair, John R Fieberg
Logistic regression models-or "sightability models"-fit to detection/non-detection data from marked individuals are often used to adjust for visibility bias in later detection-only surveys, with population abundance estimated using a modified Horvitz-Thompson (mHT) estimator. More recently, a model-based alternative for analyzing combined detection/non-detection and detection-only data was developed. This approach seemed promising, since it resulted in similar estimates as the mHT when applied to data from moose (Alces alces) surveys in Minnesota...
2018: PloS One
https://www.readbyqxmd.com/read/29329101/spatial-variation-of-endotoxin-concentrations-measured-in-ambient-pm10-in-a-livestock-dense-area-implementation-of-a-land-use-regression-approach
#16
Myrna M T de Rooij, Dick J J Heederik, Erik J H M van Nunen, Isabella J van Schothorst, Catharina B M Maassen, Gerard Hoek, Inge M Wouters
BACKGROUND: Results from studies on residential health effects of livestock farming are inconsistent, potentially due to simple exposure proxies used (e.g., livestock density). Accuracy of these proxies compared with measured exposure concentrations is unknown. OBJECTIVES: We aimed to assess spatial variation of endotoxin in PM10 (particulate matter ≤10μm) at residential level in a livestock-dense area, compare simple livestock exposure proxies to measured endotoxin concentrations, and evaluate whether land-use regression (LUR) can be used to explain spatial variation of endotoxin...
January 11, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29328545/computer-simulation-elucidates-yeast-flocculation-and-sedimentation-for-efficient-industrial-fermentation
#17
Chen-Guang Liu, Zhi-Yang Li, Yue Hao, Juan Xia, Feng-Wu Bai, Muhammad Aamer Mehmood
Flocculation plays an important role in the immobilized fermentation of biofuels and biochemicals. It is essential to understand the flocculation phenomenon at physical and molecular scale; however, flocs can't be studied directly due to fragile nature. Hence, the present study was focused on the morphological specificities of yeast flocs formation and sedimentation via the computer simulation by a single floc growth model, based on Diffusion-Limited Aggregation (DLA) model. The impact of shear force, adsorption, and cell propagation on porosity and floc size was systematically illustrated...
January 12, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29328098/demonstration-of-single-shot-digital-holography-using-a-bayesian-framework
#18
Casey J Pellizzari, Matthias T Banet, Mark F Spencer, Charles A Bouman
In this paper, we present experimental results for image reconstruction, with isoplanatic phase-error correction, from single-shot digital holography data. We demonstrate the utility of using a model-based iterative reconstruction (MBIR) algorithm to jointly compute the maximum a posteriori estimates of the phase errors and the real-valued object reflectance function. Specifically, we show that the MBIR algorithm is robust to noise and phase errors over a range of conditions.
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29327460/nanocrystal-polymer-particles-extended-delivery-carriers-for-osteoarthritis-treatment
#19
Pierre Maudens, Christian Alexander Seemayer, Cédric Thauvin, Cem Gabay, Olivier Jordan, Eric Allémann
An efficient treatment for osteoarthritis (OA) can benefit from the local release of a high therapeutic dose over an extended period of time. Such a treatment will minimize systemic side effects and avoid the inconvenience of frequent injections. To this aim, nanocrystal-polymer particles (NPPs) are developed by combining the advantages of nanotechnology and microparticles. Nanocrystals are produced by wet milling kartogenin (KGN), which is known to promote chondrogenesis and to foster chondroprotection. A fluorescent biodegradable polymer is synthesized for intravital particle tracking...
January 12, 2018: Small
https://www.readbyqxmd.com/read/29327335/classification-and-characterization-of-postural-transitions-using-instrumented-shoes
#20
Christopher Moufawad El Achkar, Constanze Lenbole-Hoskovec, Anisoara Paraschiv-Ionescu, Kristof Major, Kamiar Aminian, Christophe Büla
The frequency and quality of sit-to-stand and stand-to-sit postural transitions decrease with age and are highly relevant for fall risk assessment. Accurate classification and characterization of these transitions in daily life of older adults are therefore needed. In this study, we propose to use instrumented shoes for postural transition classification as well as transition duration estimation from insole force signals. In the first part, data were collected with 10 older adults and 10 young participants performing transitions in the laboratory while wearing the instrumented shoes, without arm assistance...
January 12, 2018: Medical & Biological Engineering & Computing
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