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effects of oral isotretinoin

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https://www.readbyqxmd.com/read/29729107/which-acne-treatment-has-the-best-influence-on-health-related-quality-of-life-literature-review-by-the-european-academy-of-dermatology-and-venereology-task-force-on-quality-of-life-and-patient-oriented-outcomes
#1
REVIEW
P V Chernyshov, L Tomas-Aragones, L Manolache, A Svensson, S E Marron, A W M Evers, V Bettoli, G B Jemec, J C Szepietowski
According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) most of publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO decided to detect which acne treatment has the best influence on HRQoL of acne patients. A new literature search was organized to find publications on acne treatment where the HRQoL of patients was assessed as an outcome measure...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29564872/reducing-the-oral-isotretinoin-skin-side-effects-efficacy-of-8-omega-ceramides-hydrophilic-sugars-5-niacinamide-cream-compound-in-acne-patients
#2
Maria V Cannizzaro, Annunziata Dattola, Virginia Garofalo, Ester Del Duca, Luca Bianchi
BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment...
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29542350/pharmacotherapy-of-retinal-disease-with-visual-cycle-modulators
#3
Rehan M Hussain, Ninel Z Gregori, Thomas A Ciulla, Byron L Lam
Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular degeneration (AMD), all blinding diseases that lack effective treatment options. Areas covered: The authors review investigational VCMs, including oral retinoids, 9-cis-retinyl-acetate (zuretinol) and 9-cis-β-carotene, which restore 11-cis-retinal levels in RP and LCA caused by LRAT and RPE65 gene mutations, and may improve visual acuity and visual fields...
March 15, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29537444/efficacy-and-safety-of-adapalene-0-3-benzoyl-peroxide-2-5-gel-plus-oral-doxycycline-in-subjects-with-severe-inflammatory-acne-who-are-candidates-for-oral-isotretinoin
#4
James Q Del Rosso, Linda Stein Gold, Sandra Marchese Johnson, Maria Jose Rueda, Hilary Baldwin, Edward L Lain, Megan Landis, Marta Rendon, Emil Tanghetti, Jonathan Weiss
INTRODUCTION: Acne treatment guidelines suggest a combination approach with topical therapy including a topical retinoid, benzoyl peroxide and an oral antibiotic, or oral isotretinoin (OI), as first-line treatment options for severe acne vulgaris (AV). This study evaluated the efficacy and safety of a daily regimen of 0.3% adapalene and 2.5% benzoyl peroxide (0.3% A/BPO) gel and oral doxycycline 100 mg twice daily in severe (nonnodulocystic, non-conglobate) inflammatory AV. METHODS: This was a phase 4, 12-week, single-arm, openlabel, multi-center investigational study...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29464980/evaluation-the-efficacy-of-trichloroacetic-acid-tca-33-in-treatment-of-oral-retinoid-induced-cheilitis-compared-with-placebo-vaseline-a-randomized-pilot-study
#5
Parvin Mansouri, Zahra Azizian, Somayeh Hejazi, Reza Chalangari, Katalin Martits Chalangari
BACKGROUND: Oral Isotretinoin (13-cis-retinoic acid) is a gold standardtreatment for severe forms of acne with cheilitis as a most frequent complication. We designed this novel study to investigate the therapeutic effect of trichloroacetic acid (TCA) 33% as compared with placebo to treat cheilitis. METHODS: In this pilot study, 90 acne vulgaris patients between 18 and 50 years, who referred dermatologic clinic with cheilitis, were assigned to either case (TCA) or control (Vaseline) group using permuted-block randomization from 2013 to 2015 with data analysis in 2016...
March 6, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29460332/vitamin-d-levels-in-acne-vulgaris-patients-treated-with-oral-isotretinoin
#6
Mohammed Abu El-Hamd, Moustafa A El Taieb, Hassan M Ibrahim, Sanaa S Aly
BACKGROUND/OBJECTIVES: Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. This study aimed to assess serum levels of 25 hydroxy vitamin D in patients with acne vulgaris before and after treatment with isotretinoin and its relation with acne vulgaris severity. METHODS: Ninety patients with acne vulgaris and 60 age-sex matched healthy subject as controls have been recruited in this study...
February 20, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29417084/comparing-the-efficacy-of-low-dose-and-conventional-dose-of-oral-isotretinoin-in-treatment-of-moderate-and-severe-acne-vulgaris
#7
Gita Faghihi, Fatemeh Mokhtari, Nasrin Motamedi Fard, Narges Motamedi, Sayed Mohsen Hosseini
Objective: This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne. Methods: This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The patients were divided into two treatment groups: 0.5 mg/kg/day isotretinoin capsule and low-dose isotretinoin capsule (0.25 mg/kg/day). Patients in both groups received 6-month treatment. At the end of the 6th month and 12th month (6 months after the end of the treatment), they were examined again, and their improvement was determined and compared...
October 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29364446/morbihan-disease-a-therapeutic-challenge
#8
Fernanda Cabral, Lara Caroline Lubbe, Monisa Martins Nóbrega, Daniel Lago Obadia, Roberto Souto, Alexandre Carlos Gripp
Morbihan disease is a rare condition characterized by chronic and persistent erythematous solid edema localized on the face. It is believed to be a complication of rosacea and may occur at any stage of the disease. Features of this condition include variable therapeutic response and great refractoriness. We report a case of a 61-year-old man with rosacea history diagnosed with Morbihan disease, who showed excellent therapeutic response with the combination of deflazacort and oral isotretinoin but developed recurrence after corticosteroid discontinuation...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29313960/isotretinoin-treatment-for-folliculitis-decalvans-a-retrospective-case-series-study
#9
Berna Aksoy, Asli Hapa, Emine Mutlu
BACKGROUND: The literature includes only a few reports of oral isotretinoin for the treatment of folliculitis decalvans (FD). This study aimed to determine the most effective dose and duration of oral isotretinoin monotherapy for achieving remission in FD patients. METHODS: This retrospective case series study included FD patients that were treated with oral isotretinoin. Patient demographics, clinical characteristics, and treatment details were obtained from the patients' medical records...
February 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29285959/kyrle-s-disease-effectively-treated-with-oral-isotretinoin
#10
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
BACKGROUND: Kyrle's disease (KD) is a primary perforating dermatosis that affects more commonly 30-50 year old females, and clinically characterized by pruritic hyperkeratotic and ulcerated nodules, papules and plaques, localized on extensor surface of upper and lower limbs, and on the trunk. OBJECTIVE: To determine the effectiveness of the treatment with oral isotretinoin in KD. METHODS: We present the case of a 63-year-old woman with hyperkeratotic, erythematous-brown nodules and plaques localized on arms and legs, intensely itching; some lesions were ulcerated and discharging...
January 10, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29249250/-what-s-new-in-pediatric-dermatology
#11
C Chiaverini
The year 2017 in pediatric dermatology was marked by several consensus recommendations and meta analyzes on childhood psoriasis, atopic dermatitis or PHACE syndrome, case series on the role of anti-JAK treatment in adolescent with alopecia areata, sirolimus for vascular malformations, ivermectine for rosacea, inhibitors of MEK for type 1 neurofibromatosis or on the side effects of the oral isotretinoin for acne or propranolol for immature hemangioma. Only few randomized controlled studies have been published on the interest of adalimumab in the treatment of psoriasis or topical sirolimus for angiofibroma in tuberous sclerosis complex for example...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29190629/suppressed-adiponectin-levels-and-increased-adiponectin-response-to-oral-glucose-load-in-lean-women-with-severe-acne-normalizes-after-isotretinoin-treatment
#12
Kadriye Aydin, Fatma Çetinözman, Gonca Elcin, Duygu Yazgan Aksoy, Fatma Ucar, Bulent O Yildiz
BACKGROUND/AIM: Isotretinoin, the drug of choice for severe acne, might be associated with a decrease in insulin sensitivity. Adiponectin is an adipose tissue-derived protein that increases insulin sensitivity. In this study, we aimed to investigate adiponectin levels in postadolescent severe acne and the effect of isotretinoin on adiponectin levels. METHODS: Participants included 18 female patients with severe acne and 18 healthy women matched for age and body mass index (BMI)...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29030873/a-feasibility-study-for-a-triple-blind-randomized-controlled-trial-investigating-the-effects-of-oral-isotretinoin-on-mood-and-quality-of-life-in-patients-with-acne-vulgaris
#13
RANDOMIZED CONTROLLED TRIAL
S Rea, S Tucker, V Frittelli, R Gunnarsson
Isotretinoin is used in the treatment of severe acne vulgaris (AV), but has controversially been associated with depression and suicide. Large prospective studies have failed to translate this clinically. We undertook a feasibility study to investigate the parameters of a triple-blind, randomized controlled trial (RCT) assessing the effect of oral isotretinoin on quality of life (QoL) and mood in patients with AV. Patients meeting the inclusion criteria were randomized for 2 weeks to isotretinoin or doxycycline...
January 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28979664/oily-skin-a-review-of-treatment-options
#14
REVIEW
Dawnielle C Endly, Richard A Miller
One of the most common dermatologic concerns is oily skin, and the demand for effective treatment options is ever apparent. This review article addresses numerous topical treatment options such as retinoids, olumacostat glasaretil, and various cosmeceutical agents. several systemic and procedural techniques that incorporate isotretinoin, spironolactone, oral contraceptives, botulinum toxin, photodynamic therapy, and lasers are reviewed as well. Each treatment option is analyzed in terms of the proposed mechanism of action, efficacy reported in the literature, and potential adverse effects...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28901534/evaluation-of-the-efficacy-and-safety-of-oral-isotretinoin-versus-topical-isotretinoin-in-the-treatment-of-plane-warts-a-randomized-open-trial
#15
Gagan J Kaur, Balvinder K Brar, Sumir Kumar, Sukhmani K Brar, Baltej Singh
BACKGROUND: Plane warts are a common therapeutic problem. Our aim was to assess the efficacy and safety of oral versus topical isotretinoin in the treatment of plane warts. METHODS: Forty patients with multiple plane warts were randomized into two groups. Group A was treated with oral isotretinoin capsules in the dose of 0.5 mg/kg/d and Group B with topical isotretinoin 0.05% in gel formulation once daily at night. Treatment was given to the patients for 3 months or until the complete clearance of lesions, whichever was earlier...
December 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28853175/safety-of-non-ablative-fractional-laser-for-acne-scars-within-1-month-after-treatment-with-oral-isotretinoin-a-randomized-split-face-controlled-trial
#16
Sandeep S Saluja, Matthew L Walker, Erika M Summers, Payam Tristani-Firouzi, David R Smart
BACKGROUND AND OBJECTIVE: Based on reports of poor wound healing and scarring, it is currently recommended that patients wait 6 months after completion of oral isotretinoin therapy before the safe initiation of laser treatment. Our aim was to evaluate the safety of non-ablative fractional laser (NAFL) treatment for acne scars within 1 month after isotretinoin therapy. STUDY DESIGN/METHODS: This was a randomized split-face controlled trial involving 10 patients with acne scars who had completed isotretinoin treatment...
December 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28791981/the-oral-adverse-effects-of-isotretinoin-treatment-in-acne-vulgaris-patients-a-prospective-case-control-study
#17
U Erdemir, G Okan, S Gungor, B Tekin, S O Yildiz, E Yildiz
BACKGROUND: Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is known on dental side effects over the course of treatment. OBJECTIVES: This prospective case-control study aimed to evaluate the oral adverse effects of isotretinoin in Turkish patients with acne vulgaris; compare oral conditions between patients and normal controls; and investigate the association between salivary parameters and International Caries Detection and Assessment System (ICDAS) scores...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28790988/non-antibiotic-isotretinoin-treatment-differentially-controls-propionibacterium-acnes-on-skin-of-acne-patients
#18
Angela E Ryan-Kewley, David R Williams, Neill Hepburn, Ronald A Dixon
Emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. Remarkably, non-antibiotic therapy in the form of isotretinoin - a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe Propionibacterium acnes which is causally involved in the complex pathogenesis of Acne vulgaris. This study measured the extent of colonization of P. acnes in patients with primary cystic or severe acne from three defined skin sites in 'non-lesion' areas before, during and after treatment with isotretinoin...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28730603/hidradenitis-suppurativa-in-children-treated-with-finasteride-a-case-series
#19
Fernando Mota, Susana Machado, Manuela Selores
BACKGROUND: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. METHODS: Patients were treated with oral finasteride 1 to 5 mg/day. All had entered puberty at the time of treatment initiation. All had normal laboratory results before starting treatment...
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28728857/-rosacea-new-data-for-better-care
#20
B Cribier
In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents...
August 2017: Annales de Dermatologie et de Vénéréologie
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