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effects of oral isotretinoin

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https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#1
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28542914/efficacy-and-adverse-events-of-oral-isotretinoin-for-acne-a-systematic-review
#2
REVIEW
I A Vallerand, R T Lewinson, M S Farris, C D Sibley, M L Ramien, A G M Bulloch, S B Patten
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total n=760 patients randomized), containing mostly males. Mean treatment ages ranged from 18 to 47.9 years and participants generally had moderate-severe acne...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28492216/psychological-status-and-quality-of-life-in-acne-patients-treated-with-oral-isotretinoin
#3
Dubravka Šimić, Jasna Zeljko Penavić, Dragan Babić, Anita Gunarić
INTRODUCTION: The acne patients are at higher risk of acquiring depresion and anxiety, which can lead to reduced quality of life. Effective treatment of acne can reduce symptoms of anxiety and depression and significantly improve other physiological parameters and quality of life of these patients. The aim of this study was to determine the psychological status and quality of life of acne patients before, during and after the treatment with oral isotretinoin. SUBJECTS AND METHODS: The prospective study included a total of 127 patients suffering from moderate to severe form of acne...
May 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28458939/isotretinoin-as-a-possible-environmental-trigger-to-autoimmunity-in-genetically-susceptible-patients
#4
Jocelyn Nugroho, Bahareh Schweiger
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28295859/adverse-effects-of-isotretinoin-a-large-retrospective-review
#5
Piotr Brzezinski, Katarzyna Borowska, Anca Chiriac, Janusz Smigielski
Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Inclusion criteria into this study were moderate, severe, and nodulocystic inflammatory acne vulgaris. Exclusion criteria were mild acne, pregnant, and lactating women...
March 14, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28076744/modern-management-of-acne
#6
REVIEW
Alan J Cooper, Victoria Rebecca Harris
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects...
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/27917684/the-long-term-effect-of-oral-isotretinoin-therapy-on-macula-ganglion-cell-complex-thickness
#7
Gülizar Demirok, Yasemin Topalak, Özge Gündüz, Dilsun Yildirim, Mehmet Fatih Kocamaz, Ahmet Şengün
PURPOSE: To evaluate the long-term effect of oral isotretinoin therapy on macula ganglion cell complex (GCC) thickness by spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Newly diagnosed cystic acne patients who received low dose for a long time systemic isotretinoin therapy were included in this study. Thorough ophthalmic evaluation and GCC thickness analysis by using SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27843919/rosacea-management
#8
REVIEW
Manal Abokwidir, Steven R Feldman
BACKGROUND: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. PURPOSE: To review the different kinds of management for all subtypes. METHODS: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. RESULTS: Flushing is better prevented rather than treated, by avoiding specific triggers, decreasing transepidermal water loss by moisturizers, and blocking ultraviolet light...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27796155/investigation-of-the-effects-of-systemic-isotretinoin-treatment-on-retinal-nerve-fiber-layer-and-macula
#9
Uğur Yılmaz, Erkut Küçük, Çağdaş Koç, Ayşe Özköse
PURPOSE: To investigate the effects of systemic isotretinoin therapy on retina by measuring retinal nerve fiber layer (RNFL) and macular thicknesses. METHOD: This prospective, cross-sectional study was conducted in patients prescribed systemic isotretinoin therapy. Seventy-two eyes of 36 patients were included in the study. The patients were followed during three months. Detailed ophthalmologic examination including anterior and posterior segment examination, best corrected visual acuity and intraocular pressure measurement, RNFL and macular thicknesses measurement by Spectral Domain Cirrus Optical Coherence Tomography Model 400 (Carl Zeiss Meditech, Jena, Germany) were performed at baseline, first, second and third months after the beginning of systemic isotretinoin therapy in ophthalmology clinic...
June 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27738837/utilizing-non-ablative-fractional-photothermolysis-prior-to-ala-photodynamic-therapy-in-the-treatment-of-acne-vulgaris-a-case-series
#10
Sarah Qureshi, Jennifer Y Lin
Aminolevulinic acid (ALA) photodynamic therapy (PDT) is an emerging modality in the treatment of acne. While ablative fractional lasers have been used to enhance drug delivery into the epidermis, recent evidence suggests that non-ablative fractional photothermolysis may also improve uptake of ALA. We explored the use of non-ablative 1550 nm laser as a safe alternative in the delivery of ALA prior to red-light PDT for refractory inflammatory and cystic acne. Subjects referred for treatment of acne refractory to several topical and oral regimens, including isotretinoin, were pre-treated with non-ablative fractional photothermolysis (NAFP)...
April 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/27730033/a-randomized-comparative-trial-of-two-low-dose-oral-isotretinoin-regimens-in-moderate-to-severe-acne-vulgaris
#11
Daulat Ram Dhaked, Ram Singh Meena, Anshul Maheshwari, Uma Shankar Agarwal, Saroj Purohit
BACKGROUND: Oral isotretinoin is highly effective in all forms and grades of acne, even in lower dosages (<0.5 mg/kg/day). There is a paucity of comparative data on the various low-dose regimens of oral isotretinoin in the Indian literature. OBJECTIVES: To assess and compare the efficacy and tolerability of two low-dose oral isotretinoin treatment regimens (20 mg daily and 20 mg alternate days) in moderate to severe acne vulgaris. MATERIALS AND METHODS: A total of 240 patients with moderate to severe acne vulgaris were selected and randomized into two groups and treated with a fixed dose of 20 mg of isotretinoin (Group A - daily and Group B - alternate days) for 24 weeks and followed up for 12 weeks post therapy...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27617470/diclofenac-sodium-3-gel-for-darier-s-disease-treatment
#12
LETTER
Sergio Santos-Alarcon, Celia Sanchis-Sanchez, Almudena Mateu-Puchades
BACKGROUND: Darier's disease (DD) is an autosomal dominant skin disorder which causative gene, ATP2A2, is located atchromosome 12q23-24. The lesions of DD are skin-coloured to brown, hyperkeratotic, greasy papules that coalesce into warty plaques commonly involving the seborrhoeic areas of the trunk and face, especially the scalp margins, temples, ears, and scalp. The most common complaint associated with the disease is itching, with exacerbations attributed to heat, sweating, sunlight, lithium, steroid therapy, stress, and menstruation OBJECTIVES: We report a patient with DD treated with topical diclofenac sodium 3%...
April 18, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27605902/effects-of-isotretinoin-on-body-mass-index-serum-adiponectin-leptin-and-ghrelin-levels-in-acne-vulgaris-patients
#13
Bengu Cevirgen Cemil, Havva Hilal Ayvaz, Gulfer Ozturk, Can Ergin, Havva Kaya Akıs, Muzeyyen Gonul, Ercan Arzuhal
INTRODUCTION: Isotretinoin has been successfully used for the treatment of acne vulgaris. AIM: To investigate the effects of isotretinoin on body mass index (BMI), to determine whether isotretinoin causes any changes in serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients, and to correlate variables. MATERIAL AND METHODS: Thirty-two patients were included in this study. Oral isotretinoin was begun at a dose of 0.5-0.6 mg/kg and raised to 0...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27571439/the-weeks-and-the-cumulative-doses-of-the-first-adverse-events-related-to-oral-isotretinoin-in-acne-patients-analysis-of-300-patients
#14
Duriye Deniz Demirseren, Fadime Kilinc, Selma Emre, Mesut Akyol, Ahmet Metin, Akin Aktas
BACKGROUND: The purpose of our study is to find out in which weeks and in which cumulative doses the side effects emerge and to study whether or not there is a significant variance between the observed period and doses of the emergent side effects of the patients taking the daily doses of below and above 0.5 mg/kg. METHODS: Patients were started treatment with doses of 0.25-1 mg/kg isotretinoin, and a form was given to the patients to mark which probable side effects occurred in which weeks and called for weekly follow-up for the first 2 months...
June 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27419807/observational-retrospective-study-evaluating-the-effects-of-oral-isotretinoin-in-keloids-and-hypertrophic-scars
#15
Lilia R S Guadanhim, Rubens G Gonçalves, Ediléia Bagatin
BACKGROUND: Acne vulgaris is a chronic inflammatory disease characterized by non-inflammatory and inflammatory lesions that can cause scarring. Oral isotretinoin is the current recommended treatment for moderate and severe cases; however, there are reports of possible influences on the healing process of the skin, leading to an increase in the risk for hypertrophic scars and keloids. This hypothesis, although unproven, represents a contraindication to the treatment of acne scars during the 6-12 months after the cessation of isotretinoin...
November 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27398012/surgical-outcome-in-patients-taking-concomitant-or-recent-intake-of-oral-isotretinoin-a-multicentric-study-iso-aims-study
#16
Omprakash Heggadahalli Mahadevappa, Venkataram Mysore, Vishalakshi Viswanath, Salim Thurakkal, Imran Majid, Suresh Talwar, Sanjeev J Aurangabadkar, Manas Chatterjee, M Ramesh Bhat, Shyamanta Barua, Anil Ganjoo
BACKGROUND: The current standard recommendation is to avoid surgical interventions in patients taking oral isotretinoin. However, this recommendation has been questioned in several recent publications. AIM: To document the safety of cosmetic and surgical interventions, among patients receiving or recently received oral isotretinoin. MATERIALS AND METHODS: Association of Cutaneous Surgeons, India, in May 2012, initiated this study, at 11 centers in different parts of India...
April 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27346869/interpretation-of-biochemical-tests-using-the-reference-change-value-in-monitoring-adverse-effects-of-oral-isotretinoin-in-102-ethnic-turkish-patients
#17
Guler Bugdayci, Mualla Polat, Hamdi Oguzman, Havva Yasemin Cinpolat
OBJECTIVES: The aim of this study was to model the use of reference change values (RCVs) for the follow-up of 4 parameters of patients using oral isotretinoin which is gaining widespread popularity for monitoring the side effects of the treatment. METHOD: 102 patients received 30 mg/day oral isotretinoin for 24 weeks for the diagnosis of acne vulgaris. RESULTS: Repetitive measurements of the patients were interpreted with RCVs, after comparing the first and second doses based on RCVs: TC, TG, AST and ALT results increased in 12%, 20%, 14% and 12% of the patients respectively...
August 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27317530/depression-screening-using-health-questionnaires-in-patients-receiving-oral-isotretinoin-for-acne-vulgaris
#18
EDITORIAL
Kory Schrom, Terri Nagy, Eliot Mostow
Isotretinoin is used to treat severe and recalcitrant acne. Possible side effects include depression, suicide, and suicidal ideation; however, other studies suggest isotretinoin may improve mood and quality of life. Although iPLEDGE consenting warns about the risk of depression and suicidal ideation, there is no recommendation for screening tools. The patient health questionnaire-2 and the patient health questionnaire-9 are validated instruments that enable dermatologists to efficiently screen for depression before and after isotretinoin is initiated...
July 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27160965/the-safety-of-isotretinoin-in-patients-with-lupus-nephritis-a-comprehensive-review
#19
REVIEW
Bartosz Miziołek, Beata Bergler-Czop, Anna Stańkowska, Ligia Brzezińska-Wcisło
Oral isotretinoin (13-cis-retinoinc acid) is a derivative of vitamin A and belongs to the first generation of retinoids, which act as synthetic isomers of retinoic acid (RA). It is a very effective agent in a treatment of acne vulgaris; however, multiple side effects related to therapy with retinoids preclude the use of isotretinoin in less severe acne vulgaris. A significant limitation for the administration of isotretinoin appears in case of concomitant kidney disease with a special attention regarding the safety of the agent in patients with lupus nephritis (LN)...
March 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27151312/isotretinoin-use-for-acne-vulgaris-is-associated-with-increased-serum-uric-acid-levels
#20
Berna Solak, Teoman Erdem, Yalcin Solak
A few previous case reports related vitamin A and retinoid use with elevated serum uric acid (SUA) levels. Recently, a population based study showed an independent positive correlation of serum retinol with SUA levels. Despite increasing importance of SUA in a number of disease states, no study has examined the association between retinoids and SUA. We aimed to evaluate the effect of pharmacologic dose isotretinoin on SUA level. This was a cohort study in which 51 consecutive adult patients with severe acne vulgaris who were prescribed oral isotretinoin treatment (0...
February 2017: Journal of Dermatological Treatment
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