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Sleep in elderly

Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
October 14, 2016: Clinical Therapeutics
Thomas Roth, Jed Black, Raymond Cluydts, Pascal Charef, Marzia Cavallaro, Fabrice Kramer, Gary Zammit, James Walsh
OBJECTIVE: Sleep laboratory study to determine the dose-related efficacy and safety of almorexant in elderly patients with primary chronic insomnia. METHODS: Patients aged ≥65 years with primary insomnia were enrolled into a prospective, randomized, double-blind, placebo-controlled, multicenter dose-finding study with a five-period, five-way Latin square cross-over design. Patients were randomized to one of 10 unique sequences of two-night treatment with oral almorexant 25, 50, 100, or 200 mg capsules, or matching placebo...
October 10, 2016: Sleep
A A Barbosa, M A L Miguel, S Tufik, F C Sabino, M S Cendoroglo, M Pedrazzoli
The objective of this study was to evaluate the alterations in sleep and circadian parameters during the aging process. The study sample comprises volunteers older than 18 up to 90 years of age that answered the Pittsburgh Sleep Quality Index (PSQI) and the Horne and Östberg circadian preference questionnaire. We observed that the shift to morningness with increasing age is associated with a significant worsening in sleep quality. We discuss that this sleep profile characterized by morningness and worse sleep quality observed in elderly, when compared to younger people, reflects not necessarily a pathological state, but an expected profile for this age group...
October 10, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Sujeong Mun, Kihyun Park, Younghwa Baek, Siwoo Lee, Jong-Hyang Yoo
BACKGROUND: Because the world population is aging, it has become increasingly important to focus on and meet the healthcare needs of elderly individuals. This study aims to evaluate the relationships among common symptoms experienced by the elderly, including fatigue, pain, sleep disturbance, indigestion, and depression/anger/anxiety, and to assess how these symptoms affect health-related quality of life (HRQoL) in the elderly population after adjusting for sociodemographic characteristics and diagnosed diseases...
October 13, 2016: Health and Quality of Life Outcomes
Xinqi Zhou, Taoyu Wu, Jing Yu, Xu Lei
Accumulating evidence supports that sleep deprivation (SD) and aging have similar effects: decreased cognition performance and impaired brain function. Some investigators even proposed the SD as a model of aging. However, few direct comparisons were ever explored between the effects of SD and aging by network module analysis with the resting-state fMRI. In this study, both within- and between-module connectivities were calculated in the whole brain to describe a complete picture of brain networks' functional connectivity among three groups (young normal sleep, young SD and old group)...
October 12, 2016: Brain Connectivity
Johannes M Just, Klaus Weckbecker, Katja S Just
BACKGROUND: Nocturnal leg cramps are painful, involuntary muscle contractions commonly seen in elderly. While mostly harmless, they can severely impair quality of life and often disrupt sleep. Adverse drug effects may be responsible for a fraction of nocturnal leg cramps but often go unrecognized, resulting in additional prescribing intended to deal with adverse effects that might be better addressed by reduction, substitution, or discontinuation of the offending agent. CASE PRESENTATION: An 87 year old female presented as outpatient in family medicine with nocturnal leg cramps which had been present for five years and increasingly burdened her quality of life...
October 1, 2016: BMC Geriatrics
Shan Ai Quan, Yong Chun Li, Wen Jie Li, Yan Li, Jin Young Jeong, Dong Hyun Kim
Sleep is an important component in our lives as it is necessary throughout one's entire life span. This study was conducted to elucidate whether there are gender differences in sleep quality and what factors can affect sleep quality in community-dwelling elderly Koreans. A total of 382 subjects (175 males and 207 females) were recruited among elderly aged 45 or over who participated in the 2010 Hallym Aging Study (HAS). They were invited to a general hospital and were evaluated for socioeconomic status, smoking history, and various clinical measures...
November 2016: Journal of Korean Medical Science
Kui Peng, Lin Lin, Zhengyi Wang, Lin Ding, Ya Huang, Po Wang, Yu Xu, Jieli Lu, Min Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Guang Ning
BACKGROUND: Epidemiologic studies have reported conflicting results on the relationship between short sleep duration and nonalcoholic fatty liver disease (NAFLD). Previous research investigating the impact of daytime nap on NAFLD was not available. Herein, we examined the associations between nightly sleep duration, daytime nap with NAFLD in a middle-aged and elderly Chinese population. METHODS: This cross-sectional community-based population study included 8559 individuals aged 40 years or older...
October 4, 2016: Journal of Diabetes
Aileen Wk Chan, Doris Sf Yu, K C Choi, Diana Tf Lee, Janet Wh Sit, Helen Yl Chan
PURPOSE: Age-related cognitivee decline is a growing public health concern worldwide. More than a quarter of adults with cognitive impairment experience sleep disturbance. The objective of this pilot study was to evaluate the preliminary effects of tai chi qigong (TCQ) on improving the night-time sleep quality of older adults with cognitive impairment. PARTICIPANTS: Older adults with cognitive impairment who complain of sleep disturbance. METHODS: A randomized controlled trial with two groups...
2016: Clinical Interventions in Aging
Kazuko Kato, Seiko Miyata, Motoo Ando, Hiroki Matsuoka, Fumihiko Yasuma, Kunihiro Iwamoto, Naoko Kawano, Masahiro Banno, Norio Ozaki, Akiko Noda
AIMS: Short sleep duration is a risk factor for cardiovascular diseases. Cerebral blood flow and its regulation are affected by pathological conditions commonly observed in the elderly population, such as dementia, atherosclerosis, diabetes mellitus, stroke and hypertension. The purpose of this study was to examine the influence of sleep duration on cortical oxygenated hemoglobin (OxyHb) using near-infrared spectroscopy (NIRS). METHODS: Seventy-three individuals (age, 70...
October 3, 2016: Psychiatry and Clinical Neurosciences
S Sabzwari, A Munir Badini, Z Fatmi, T Jamali, S Shah
The elderly population in South Asia is growing. In Pakistan trained caregivers are scarce and culturally not acceptable. This study assessed the level of stress experienced by caregivers of the elderly and determined the association of care giving burden with different characteristics of the elderly. A cross-sectional, questionnaire based study was conducted using nonprobability purposive sampling. All consenting participants aged 60 years and above needing help with at least one activity of daily living or two instrumental activities of daily living were included...
2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Shuai Liu, Chonghui Li, Zhihong Shi, Xiaodan Wang, Yuying Zhou, Shuling Liu, Jing Liu, Tao Yu, Yong Ji
AIM: To evaluate caregiver burden and factors that influence this burden among caregivers and patients with Alzheimer's disease in China. BACKGROUND: Long-term care can reduce the quality of life for caregivers and result in both mental and physical exhaustion. However, little is known about caregiver burden and associated factors in China. DESIGN: The study had a quantitative cross-sectional design. METHODS: A total of 309 caregivers and their patients were included in the study...
September 29, 2016: Journal of Clinical Nursing
Wei-Ju Lee, Li-Ning Peng, Chih-Kuang Liang, Shu-Ti Chiou, Liang-Kung Chen
AIM: There is a complex interrelationship between long sleep duration, frailty, chronic inflammation and mortality among the community-dwelling middle-aged and elderly population, which remains unclear and deserves to be investigated. The current study intended to explore these associations by using a prospective population-based cohort study. METHODS: A total of 937 community-dwelling middle-aged and elderly people were enrolled. Sleep patterns of the study participants were categorized as short (<6 h), average or long (≥8 h)...
September 29, 2016: Geriatrics & Gerontology International
Magali Saint Martin, Emilia Sforza, Emilie Crawford-Achour, Lefèvre Pascal, Georges Lienard, Roche Frédéric
OBJECTIVE: Sleep breathing disorders (SBD) are the most common sleep disorders frequently under-diagnosed in elderly populations. However, it is it well known that this disorder may contribute to the age-related cognitive decline. In a cohort of healthy elderly subjects, we performed an 8-year longitudinal study to assess whether changes in cognitive function occur in untreated SBD elderly and the nocturnal factors implicated in these changes. MATERIAL/PATIENTS AND METHODS: A total of 559 participants of the community-based PROOF study aged 67years at the study entry and free from neurological disorders were examined...
September 2016: Annals of Physical and Rehabilitation Medicine
John E Morley
Frailty is a pre-disability syndrome where an older person can be identified as being at risk when exposed to stressors associated with high risk for disability or needing to be hospitalized. Two major frailty definitions exist. The physical phenotype of frailty and the multiple deficit model. A simple frailty screening tool-FRAIL-has been validated. Treatment of frailty involves resistance exercise, optimization of nutrition, and treatment of fatigue (sleep apnea, depression), treatable causes of weight loss and adjustment of polypharmacy...
September 26, 2016: Wiener Klinische Wochenschrift
Malcolm Koo, Juen-Haur Hwang
OBJECTIVE: To investigate the risk of tinnitus in patients with sleep disturbance or sleep apnea. STUDY DESIGN: Case control study. METHODS: We identified 21,798 middle-aged and elderly patients with otolaryngologist-diagnosed tinnitus between January 1, 2000, and December 31, 2012, from the Longitudinal Health Insurance Database 2000 of the Taiwan National Health Insurance Research Database. A total of 108,990 controls were also identified from the same database based on frequency-matching on 10-year age interval, sex, and year of index date of the cases...
September 26, 2016: Laryngoscope
Ki Woong Kim, Suk-Hoon Kang, In-Young Yoon, Sang Don Lee, Gawon Ju, Ji Won Han, Tae Hui Kim, Chung Suk Lee, Tae Kim
BACKGROUND: Insomnia is known to be associated with psychiatric disorders, other sleep disorders and medical conditions, but the prevalence of insomnia diagnosis has never been estimated according to its subtypes. We studied the prevalence and clinical characteristics of insomnia diagnosis and its subtypes in the Korean elderly population. METHODS: Among 1423 sampled elderly individuals aged 60 years or older, 881 subjects participated in this study. The Athens Insomnia Scale was applied to detect insomnia symptoms, and insomnia diagnosis was finally evaluated using the international classification of sleep disorders, 2nd edition...
September 17, 2016: Archives of Gerontology and Geriatrics
Marion Baillet, Bixente Dilharreguy, Karine Pérès, Jean-François Dartigues, Willy Mayo, Gwenaëlle Catheline
OBJECTIVE: Although aging is associated with alterations of both activity/rest cycle and brain structure, few studies have evaluated associations between these processes. The aim of this study was to examine relationship between activity/rest cycle quality and brain structural integrity in aging subjects by exploring both grey and white matter compartments. MATERIAL AND METHODS: Fifty-eight elderly subjects (76±0.5 years; 41% female) without dementia, sleep disorders and medications were included in the analysis...
September 21, 2016: NeuroImage
Timothy M Morgan, Bob Soh
AIMS: To test the feasibility of a novel rivastigmine nasal spray as prospective treatment for dementia. METHODS: A single dose, crossover absolute bioavailability and safety study was conducted with rivastigmine intravenous solution (1 mg) and nasal spray (3.126 mg) in eight healthy elderly individuals, aged 58 to 75 years. RESULTS: The absolute bioavailability (F) of the nasal spray was significant at 0.62 (0.15) for F > 0 (p < 0...
September 18, 2016: British Journal of Clinical Pharmacology
Ioulietta Lazarou, Anastasios Karakostas, Thanos G Stavropoulos, Theodoros Tsompanidis, Georgios Meditskos, Ioannis Kompatsiaris, Magda Tsolaki
BACKGROUND: Assistive technology, in the form of a smart home environment, is employed to support people with dementia. OBJECTIVES: To propose a system for continuous and objective remote monitoring of problematic daily living activity areas and design personalized interventions based on system feedback and clinical observations for improving cognitive function and health-related quality of life. METHODS: The assistive technology of the proposed system, including wearable, sleep, object motion, presence, and utility usage sensors, was methodically deployed at four different home installations of people with cognitive impairment...
October 18, 2016: Journal of Alzheimer's Disease: JAD
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