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https://www.readbyqxmd.com/read/28743157/her2-mutations-in-lung-adenocarcinomas-a-report-from-the-lung-cancer-mutation-consortium
#1
Rathi N Pillai, Madhusmita Behera, Lynne D Berry, Mike R Rossi, Mark G Kris, Bruce E Johnson, Paul A Bunn, Suresh S Ramalingam, Fadlo R Khuri
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) mutations have been reported in lung adenocarcinomas. Herein, the authors describe the prevalence, clinical features, and outcomes associated with HER2 mutations in 1007 patients in the Lung Cancer Mutation Consortium (LCMC). METHODS: Patients with advanced-stage lung adenocarcinomas were enrolled to the LCMC. Tumor specimens were assessed for diagnosis and adequacy; multiplexed genotyping was performed in Clinical Laboratory Improvement Amendments (CLIA)-certified laboratories to examine 10 oncogenic drivers...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743059/altered-connectivity-within-and-between-the-default-mode-central-executive-and-salience-networks-in-obsessive-compulsive-disorder
#2
Jie Fan, Mingtian Zhong, Jun Gan, Wanting Liu, Chaoyang Niu, Haiyan Liao, Hongchun Zhang, Jinyao Yi, Raymond C K Chan, Changlian Tan, Xiongzhao Zhu
BACKGROUND: Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them...
July 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28743044/electrophysiological-and-gene-expression-characterization-of-the-ontogeny-of-nestin-expressing-cells-in-the-adult-mouse-midbrain
#3
Anupama Dey, Parisa Farzanehfar, Elena V Gazina, Tim D Aumann
The birth of new neurons, or neurogenesis, in the adult midbrain is important for progressing dopamine cell-replacement therapies for Parkinson's disease. Most studies suggest newborn cells remain undifferentiated or differentiate into glia within the adult midbrain. However, some studies suggest nestin+neural precursor cells (NPCs) have a propensity to generate new neurons here. We sought to confirm this by administering tamoxifen to adult NesCreER(T2)/R26eYFP transgenic mice, which permanently labelled adult nestin-expressing cells and their progeny with enhanced yellow fluorescent protein (eYFP)...
July 4, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28742954/carbon-dioxide-elimination-by-cardiomyocytes-a-tale-of-high-carbonic-anhydrase-activity-and-membrane-permeability
#4
EDITORIAL
Erik R Swenson
Life as a multicellular organism requires a heart with a coordinated contractile activity that must never cease, and in this regard, it is very much like the brain with a high mass-specific 'resting' metabolic rate. To maintain this constant activity requires a high rate of oxygen consumption and resultant carbon dioxide generation and, pari passu, the rapid exchange of large amounts of these gases with capillary blood. While oxygen has been far more the focus of the two gases in cardiac physiology, the work of Arias-Hidalgo et al (1) in this issue of the journal offers new insights and better understanding of how CO2 uniquely traverses its path from production in the mitochondria to the capillary blood, and does so with much smaller driving gradients than necessary for oxygen...
July 25, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28742848/indicators-to-measure-risk-of-disaster-associated-with-drought-implications-for-the-health-sector
#5
Aderita Sena, Kristie L Ebi, Carlos Freitas, Carlos Corvalan, Christovam Barcellos
INTRODUCTION: Brazil has a large semiarid region, which covers part of 9 states, over 20% of the 5565 municipalities in the country and at 22.5 million persons, 12% of the country's population. This region experiences recurrent and extended droughts and is characterized by low economic development, scarcity of natural resources including water, and difficult agricultural and livestock production. Local governments and communities need easily obtainable tools to aid their decision making process in managing risks associated with drought...
2017: PloS One
https://www.readbyqxmd.com/read/28742607/pitch-counts-in-youth-baseball-and-softball-a-historical-review
#6
Brian T Feeley, Jessica Schisel, Julie Agel
OBJECTIVE: Pitching injuries are getting increased attention in the mass media. Many references are made to pitch counts and the role they play in injury prevention. The original purpose of regulating the pitch count in youth baseball was to reduce injury and fatigue to pitchers. This article reviews the history and development of the pitch count limit in baseball, the effect it has had on injury, and the evidence regarding injury rates on softball windmill pitching. DATA SOURCE: Literature search through PubMed, mass media, and organizational Web sites through June 2015...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742132/theory-and-development-of-biplanar-active-shim-coils-for-a-permanent-nmr-analyzer
#7
Tian Xia, Zhiying Miao, Shanshan Chen, Hongzhi Wang, Yefeng Yao
The general expression for magnetic induction in the z axis direction is derived from magnetic scalar potential, and magnetic induction for biplanar shimming coils (BSCs) is also derived from magnetic vector potentials and Green functions, which simultaneously include Sin and Cos harmonic fields. The relationship between these expressions is discussed, and we show they are partially consistent. Magnetic induction generated Sin and Cos stream functions, which are presented and discussed, and we conclude that the type of stream function determines the type of harmonic field, and that BSCs can not only generate specific harmonic fields directly using Cos stream function, but also generate the rest of the harmonic fields through some specific operations...
2017: PloS One
https://www.readbyqxmd.com/read/28742046/a-fast-algorithm-for-analysis-of-molecular-communication-in-artificial-synapse
#8
Bilgesu A Bilgin, Ozgur B Akan
In this paper we analyse molecular communications (MC) in a proposed artificial synapse (AS), whose main difference from biological synapses (BSs) is that it is closed, i.e., transmitter molecules cannot diffuse out from AS. Such a setup has both advantages and disadvantages. Besides higher structural stability, being closed, AS never runs out of transmitters. Thus, MC in AS is disconnected from outer environment, which is very desirable for possible intra-body applications. On the other hand, clearance of transmitters from AS has to be achieved by transporter molecules on the presynaptic membrane of AS...
July 21, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28741652/a-randomised-controlled-trial-of-rectus-sheath-bupivacaine-and-intrathecal-bupivacaine-without-or-with-intrathecal-morphine-vs-intrathecal-bupivacaine-and-morphine-after-caesarean-section
#9
M W Lui, T K T Li, F Lui, C Y T Ong
We recruited 144 women of whom 131 underwent scheduled caesarean section and were allocated to intrathecal bupivacaine without (46) or with (47) morphine and postoperative rectus sheath bupivacaine; or intrathecal bupivacaine with morphine and postoperative rectus sheath saline (38). We measured postoperative pain with a 10-point numeric rating scale. The mean (SD) areas under the curve for pain on movement during 48 postoperative hours were 273.5 (63.6), 223.8 (80.7) and 223.8 (80.7), respectively, p = 0.008...
July 25, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28741624/hormonal-cycle-and-contraceptive-effects-on-amygdala-and-salience-resting-state-networks-in-women-with-previous-affective-side-effects-on-the-pill
#10
Jonas Engman, Inger Sundström Poromaa, Lena Moby, Johan Wikström, Mats Fredrikson, Malin Gingnell
The mechanisms linking ovarian hormones to negative affect are poorly characterized, but important clues may come from the examination of the brain's intrinsic organization. Here, we studied the effects of both the menstrual cycle and oral contraceptives (OCs) on amygdala and salience network resting-state functional connectivity using a double-blind, randomized, and placebo-controlled design. Hormone levels, depressive symptoms, and resting-state functional connectivity were measured in 35 healthy women (24...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28741425/gabapentin-in-the-management-of-pain-following-tonsillectomy-a-randomized-double-blind-placebo-controlled-trial
#11
James G Sanders, Claire Cameron, Patrick J D Dawes
Objective To determine if a single dose of oral gabapentin given prior to tonsillectomy decreases postoperative morbidity. Study Design Prospective randomized double-blind placebo-controlled trial. Setting Southern District Health Board University Hospitals, New Zealand, over a 10-month period. Subjects and Methods Seventy-three adults undergoing tonsillectomy were randomized to receive either a single preoperative dose of oral gabapentin (600 mg) or placebo. A standard analgesic protocol was prescribed for 14 postoperative days...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28741413/modulating-children-s-manual-preference-through-spontaneous-nondominant-hand-use
#12
Juliana Maia Garcia, Luis Augusto Teixeira
We evaluated the effect of repeated use of the nonpreferred hand on young children's manual preference by positioning toys in the left hemifield in egocentric coordinates to induce right-handed 4- to 5-year-olds to use their left hands spontaneously. We induced motor activities in the laterally biased workspace by presenting tasks in a ludic context over different days, similar to their daily kindergarten experience. Preceding and following these lateralized experiences, the children were tested on a task requiring reaching, grasping, and inserting cards into a slot...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28741191/systematic-review-and-meta-analysis-of-epidural-analgesia-versus-different-analgesic-regimes-following-oesophagogastric-resection
#13
REVIEW
Michael Hughes, Ivan Yim, D A Christopher Deans, Graeme W Couper, Peter J Lamb, Richard J E Skipworth
INTRODUCTION: Effective analgesia following open oesophagogastric (OG) resection is considered a key determinant of recovery. This review aimed to compare epidural to alternative analgesic techniques in patients undergoing major open resection for OG cancer. METHODS: A systematic review and meta-analysis was conducted of randomized controlled trials comparing epidural with alternative analgesic methods in open OG surgery. Primary outcome was the overall post-operative morbidity rate...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28741009/the-role-of-dispatch-in-resuscitation
#14
Yih Yng Ng, Siew Hon Benjamin Leong, Marcus Eng Hock Ong
The role of the dispatch centre has increasingly become a focus of attention in cardiac arrest resuscitation. The dispatch centre is part of the first link in the chain of survival because without the initiation of early access, the rest of the chain is irrelevant. The influence of dispatch can also extend to the initiation of bystander cardiopulmonary resuscitation, early defibrillation and the rapid dispatch of emergency ambulances. The new International Liaison Committee on Resuscitation, the American Heart Association and, especially, the European Resuscitation Council 2015 guidelines have been increasing their emphasis on dispatch as the key to improving out-of-hospital cardiac arrest survival...
July 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28740959/idiopathic-granulomatous-mastitis-an-institutional-experience
#15
Seetharam Prasad, Padmapriya Jaiprakash, Aniket Dave, Deepti Pai
OBJECTIVE: To study idiopathic granulomatous mastitis with respect to its various clinical features, etiologic factors, treatment modalities and complications. MATERIAL AND METHODS: Retrospective study of all patients who were diagnosed with idiopathic granulomatous mastitis from 1(st) January 2006 to 31(st) December 2014 at Kasturba Hospital, Manipal, India (a tertiary care referral centre). The research was performed according to the World Medical Association Declaration of Helsinki...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740944/effect-of-mechanical-vibration-generated-in-oscillating-vibratory-platform-on-the-concentration-of-plasma-biomarkers-and-on-the-weight-in-rats
#16
Éric Heleno Freire Ferreira Frederico, Danúbia da Cunha de Sá-Caputo, Eloá Moreira-Marconi, Carlos Alberto Sampaio Guimarães, André Luiz Bandeira Dionísio Cardoso, Carla da Fontoura Dionello, Danielle Soares Morel, Cintia Renata Sousa-Gonçalves, Laisa Liana Paineiras-Domingos, Rebeca Graça Costa Cavalcanti, Nasser Ribeiro Asad, Pedro Jesus Marin, Mario Bernardo-Filho
BACKGROUND: Whole body vibration (WBV) exercise has been used in health sciences. Authors have reported that changes on the concentration of plasma biomarkers could be associated with the WBV effects. The aim of this investigation is to assess the consequences of exposition of 25 Hz mechanical vibration generated in oscillating/vibratory platform (OVP) on the concentration of some plasma biomarkers and on the weight of rats. MATERIALS AND METHODS: Wistar rats were divided into two groups...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28740941/effects-of-whole-body-vibration-intervention-on-handgrip-strength-of-brazilian-healthy-soldiers
#17
Danielle Soares Morel, Eloá Moreira-Marconi, Samuel Brandão Sobrinho Neto, Laisa Liane Paineiras Domingos, Patrícia Lopes de Souza, Danúbia da Cunha de Sá Caputo, Glenda Dias Costa, Cláudia Ferreira de Figueiredo, Roberto Carlos Resende Carmo, Patrícia de Castro de Paiva, Cintia Renata Sousa Gonçalves, Cristiane Ribeiro Kütter, Eliane de Oliveira Guedes de Aguiar, Mario Bernardo-Filho
BACKGROUND: Whole body vibration (WBV) exercises have been investigated as an alternative and complementary method to traditional resistance programs for fitness improvements in healthy subjects. Active militaries must have a high fitness level and have to improve some physical abilities to accomplish some specific tasks in Army, as climb ropes, climb walls and pull up. MATERIALS AND METHODS: Seven young and healthy soldiers from Brazilian Army were exposed to mechanical vibration in a push-up position, with different frequencies, as 25 (first session), 30 (second session), 35 (third session), 40 (fourth session) and 45 Hz (fifth session)...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28740923/a-comparison-of-interfraction-setup-error-patient-comfort-and-therapist-acceptance-for-2-different-prostate-radiation-therapy-immobilization-devices
#18
Eric Pei Ping Pang, Kellie Knight, Marilyn Baird, Joshua Ming Quan Loh, Adelene Hwee San Boo, Jeffrey Kit Loong Tuan
PURPOSE: Our purpose was to investigate interfraction setup error of the immobilization device required to implement transperineal ultrasound compared with the current, standard immobilization device. Patient comfort and radiation therapist (RT) satisfaction were also assessed. METHODS AND MATERIALS: Cone beam computed tomography images were acquired before 4069 fractions from 111 patients (control group, n = 56; intervention group, n = 55) were analyzed. The intervention group was immobilized using the Clarity Immobilization System (CIS), comprising a knee rest with autoscan probe kit and transperineal ultrasound probe (n = 55), and control group using a leg immobilizer (LI) (n = 56)...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740870/reduced-ventral-tegmental-area-hippocampal-connectivity-in-children-and-adolescents-exposed-to-early-threat
#19
Hilary A Marusak, Joshua R B Hatfield, Moriah E Thomason, Christine A Rabinak
BACKGROUND: Preclinical data suggest that early life stress has detrimental effects on the brain's dopaminergic system, particularly the mesocorticolimbic pathway. Altered dopamine function is thought to contribute to the development of stress-related pathologies; yet, little is known about the impact of early stress on dopamine systems during childhood and adolescence, when stress-related disorders frequently emerge. Here, we evaluate the impact of early threat exposure (violence, abuse) on functional connectivity of putative dopaminergic midbrain regions, the ventral tegmental area (VTA) and substantia nigra (SN), giving rise to mesocorticolimbic and nigrostriatal pathways, respectively...
March 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28740418/comparison-of-patient-controlled-intravenous-analgesia-with-sufentanil-versus-tramadol-in-post-cesarean-section-pain-management-and-lactation-after-general-anesthesia-a-prospective-randomized-double-blind-controlled-study
#20
Xiaohui Chi, Man Li, Wei Mei, Mingfeng Liao
INTRODUCTION: Acute pain is a common complication following cesarean section under general anesthesia. Post-cesarean section pain management is important for both the mother and the newborn. This study compared the effects of patient-controlled intravenous analgesia (PCIA) using sufentanil or tramadol on postoperative pain control and initiation time of lactation in patients who underwent cesarean section under general anesthesia. METHODS: Primiparas (n=146) scheduled for cesarean section under general anesthesia were randomized to receive PCIA with sufentanil or tramadol...
2017: Journal of Pain Research
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