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https://www.readbyqxmd.com/read/29466066/effect-of-graft-type-on-balance-and-hop-tests-in-adolescent-males-following-anterior-cruciate-ligament-reconstruction
#1
Dai Sugimoto, Benton E Heyworth, Jeffery J Brodeur, Dennis E Kramer, Mininder S Kocher, Lyle J Micheli
CONTEXT: Recent epidemiology studies indicated a steady increase of anterior cruciate ligament (ACL) injury in young athletes. ACL reconstruction (ACLR) is currently a standard of the care, but effect of ACLR graft including bone patellar tendon bone (BTB), hamstring tendon (HT), or iliotibial band (ITB) on balance and hop performance is understudied. OBJECTIVE: To compare balance and hop deficits between uninvolved and reconstructed limbs in each autograft type (aim 1) and among the three autograft groups (aim 2)...
February 21, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29446764/antibodies-against-glycoprotein-2-display-diagnostic-advantages-over-asca-in-distinguishing-cd-from-intestinal-tuberculosis-and-intestinal-beh%C3%A3-et-s-disease
#2
Shulan Zhang, Jing Luo, Ziyan Wu, Dirk Roggenbuck, Peter Schierack, Dirk Reinhold, Ji Li, Xiaofeng Zeng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
OBJECTIVES: There is an increasing need to identify reliable biomarkers for distinguishing Crohn's disease (CD) from other gastrointestinal disorders sharing similar clinical and pathological features. This study aimed at evaluating the diagnostic potential of antibodies to zymogen granule glycoprotein GP2 (aGP2) in a large, well-defined Chinese cohort with a special focus on their role in discriminating CD from intestinal Behçet's disease (BD) and intestinal tubercolosis (ITB). METHODS: A total of 577 subjects were prospectively enrolled, including 171 patients with CD, 208 patients with ulcerative colitis (UC), 71 with BD, 57 with ITB and 70 healthy controls (HC)...
February 15, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29439364/enhancement-of-motor-learning-by-focal-intermittent-theta-burst-stimulation-itbs-of-either-the-primary-motor-m1-or-somatosensory-area-s1-in-healthy-human-subjects
#3
Thomas Platz, Marija Adler-Wiebe, Sybille Roschka, Martin Lotze
BACKGROUND: Motor rehabilitation after brain damage relies on motor re-learning as induced by specific training. Non-invasive brain stimulation (NIBS) can alter cortical excitability and thereby has a potential to enhance subsequent training-induced learning. Knowledge about any priming effects of NIBS on motor learning in healthy subjects can help to design targeted therapeutic applications in brain-damaged subjects. OBJECTIVE: To examine whether complex motor learning in healthy subjects can be enhanced by intermittent theta burst stimulation (iTBS) to primary motor or sensory cortical areas...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29405267/pharmacological-and-neurosurgical-interventions-for-managing-dystonia-in-cerebral-palsy-a-systematic-review
#4
Darcy Fehlings, Leah Brown, Adrienne Harvey, Kate Himmelmann, Jean-Pierre Lin, Alexander Macintosh, Jonathan W Mink, Elegast Monbaliu, James Rice, Jessica Silver, Lauren Switzer, Ilana Walters
AIM: To systematically review evidence for pharmacological/neurosurgical interventions for managing dystonia in individuals with cerebral palsy (CP) to inform a care pathway. METHOD: Searches included studies with a minimum of five participants with dystonia in CP receiving oral baclofen, benzodiazepines (clonazepam, diazepam, lorazepam), clonidine, gabapentin, levodopa, trihexyphenidyl, botulinum toxin, intrathecal baclofen (ITB), or deep brain stimulation (DBS)...
February 6, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29395556/outcomes-of-arthroscopic-management-of-trochanteric-bursitis-in-patients-with-femoroacetabular-impingement-a-comparison-of-two-matched-patient-groups
#5
Alexander R Vap, Justin J Mitchell, Karen K Briggs, Shannen C McNamara, Marc J Philippon
PURPOSE: To determine the prevalence of chronic trochanteric bursitis (TB) in patient being treated for femoroacetabular impingement (FAI) and determine the effectiveness of arthroscopic bursectomy and iliotibial band lengthening (AB-ITB-L) at the time of hip arthroscopy for FAI. METHODS: Patients diagnosed with primary FAI and chronic TB were included in the study. Patients were included if they underwent hip arthroscopy with labral repair, femoral and/or acetabular osteoplasty, and AB-ITB-L...
January 27, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29389221/the-augmentation-of-revision-anterior-cruciate-ligament-reconstruction-with-modified-iliotibial-band-tenodesis-to-correct-the-pivot-shift-a-computer-navigation-study
#6
Mark D Porter, Bruce Shadbolt, Samantha Pomroy
BACKGROUND: Iliotibial band (ITB) tenodesis improves stability and functional outcomes when added to anterior cruciate ligament (ACL) reconstruction. Its precise indications are unknown. Persistence of the pivot shift after revision ACL reconstruction may be one indication. HYPOTHESIS: The addition of ITB tenodesis for a persistent pivot shift after revision ACL reconstruction will improve stability and activity levels. STUDY DESIGN: Cohort study; Level of evidence, 2...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29374195/restrained-management-of-copper-level-enhances-the-antineoplastic-activity-of-imatinib-in-vitro-and-in-vivo
#7
Iftekhar Hassan, Azmat Ali Khan, Shazia Aman, Wajhul Qamar, Hossam Ebaid, Jameel Al-Tamimi, Ibrahim M Alhazza, Ahmed M Rady
The present study was designed to investigate if elevated copper level can be targeted to enhance the efficacy of a significant anticancer drug, imatinib (ITB). The antineoplastic activity of this drug was assessed in the HepG2, HEK-293, MCF-7 and MDA-MD-231 cells targeting elevated copper level as their common drug target. The cell lines were treated with the different doses of copper chloride (Cu II) and disulfiram (DSF) alone as well as in their combinations with the drug for 24 h in standard culture medium and conditions...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29373059/dynamic-varus-and-the-development-of-iliotibial-band-syndrome
#8
Christopher D Stickley, Melanie M Presuto, Kara N Radzak, Christina M Bourbeau, Ronald K Hetzler
CONTEXT:   Although the risk of osteoarthritis development after acute knee injury has been widely studied, the long-term consequences of knee overuse injury are not well understood. OBJECTIVE:   To identify the relationship between gait-related risk factors osteoarthritis and the development of iliotibial band syndrome (ITBS) in members of a single University Army Reserve Officers' Training Corps (ROTC) unit. DESIGN:   Prospective cohort study...
January 26, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29361639/outcome-of-low-invasive-local-split-thickness-lengthening-for-iliotibial-band-friction-syndrome
#9
Hiroaki Inoue, Kunio Hara, Yuji Arai, Shuji Nakagawa, Hiroyuki Kan, Manabu Hino, Hiroyoshi Fujiwara, Toshikazu Kubo
Conventional surgical methods for iliotibial band friction syndrome (ITBFS) may affect the iliotibial band (ITB), delaying return to sports activities or impeding performance. We have developed a minimally invasive method. This study retrospectively analyzed the outcomes of this procedure in individuals with ITBFS. This study included 34 knees of 31 individuals. Surgery involved lengthening the central part of the ITB by splitting it into a superficial and a deep layer, maintaining the anterior and posterior fibers immediately above the lateral epicondyle...
January 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29352668/the-effect-of-single-and-repeated-prefrontal-intermittent-theta-burst-stimulation-on-cortical-reactivity-and-working-memory
#10
Sung Wook Chung, Nigel C Rogasch, Kate E Hoy, Paul B Fitzgerald
BACKGROUND: With an increasing interest in the use of theta burst stimulation (TBS) as a cognitive enhancer and a potential therapeutic tool for psychiatric disorders, there is a need to identify optimal parameters of TBS in the prefrontal cortex. OBJECTIVE/HYPOTHESIS: This study examined the effect of two blocks of prefrontal intermittent TBS (iTBS) on cortical reactivity and working memory performance, compared to one block of iTBS and sham stimulation. We hypothesized that greater cortical effects would be obtained with two blocks of iTBS...
January 8, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29349778/intrathecal-baclofen-therapy-in-children-an-analysis-of-individualized-goals
#11
Peck Yee Liew, Kirsty Stewart, Debra Khan, Sarah Jane Arnup, Adam Scheinberg
AIM: To determine whether intrathecal baclofen (ITB) therapy improves performance and performance satisfaction in goal areas identified by patients' parents. METHOD: This study formed part of an ongoing multicentre national audit involving six paediatric ITB pump implant centres across Australia. The Canadian Occupational Performance Measure was the primary outcome measure utilized at baseline, 6 months, and 12 months after pump implants in paediatric patients receiving ITB therapy for the first time between 31st December 2009 and 31st December 2014...
January 19, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29326296/intrathecal-baclofen-therapy-versus-conventional-medical-management-for-severe-poststroke-spasticity-results-from-a-multicentre-randomised-controlled-open-label-trial-sisters
#12
Michael Creamer, Geoffrey Cloud, Peter Kossmehl, Michael Yochelson, Gerard E Francisco, Anthony B Ward, Jörg Wissel, Mauro Zampolini, Abdallah Abouihia, Nathalie Berthuy, Alessandra Calabrese, Meghann Loven, Leopold Saltuari
BACKGROUND: Intrathecal baclofen (ITB) is a treatment option for patients with severe poststroke spasticity (PSS) who have not reached their therapy goal with other interventions. METHODS: 'Spasticity In Stroke-Randomised Study' (SISTERS) was a randomised, controlled, open-label, multicentre phase IV study to evaluate the efficacy and safety of ITB therapy versus conventional medical management (CMM) with oral antispastic medications for treatment of PSS. Patients with chronic stroke with spasticity in ≥2 extremities and an Ashworth Scale (AS) score ≥3 in at least two affected muscle groups in the lower extremities (LE) were randomised (1:1) to ITB or CMM...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29305879/reproductive-stage-and-sex-dependant-effects-of-neurohypophyseal-nonapeptides-on-gonadotropin-subunit-mrna-expression-in-the-catfish-heteropneustes-fossilis-an-in-vitro-study
#13
A Acharjee, R Chaube, K P Joy
In the present study, in vitroeffects of synthetic vasotocin (VT), isotocin (4Ser, 8Ile- oxytocin; ITb) and the recently cloned IT gene paralog product (8Val-Isotocin, ITa) were studied onthe expression of pituitary gonadotropin (GtH) subunit mRNA levels. In male pituitaries of early (preparatory phase) and late (prespawning phase) recrudescing catfish, Heteropneustes fossilis, VT (10 nM, 100 nM and 1000 nM) stimulated fshβ expression dose-dependently. But in females, the dose-dependent effect was found only in the preparatory phase...
January 3, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29304065/bilateral-theta-burst-magnetic-stimulation-influence-on-event-related-brain-potentials
#14
Nuno Pinto, Marta Duarte, Helena Gonçalves, Ricardo Silva, Jorge Gama, Maria Vaz Pato
Theta-burst stimulation (TBS) can be a non-invasive technique to modulate cognitive functions, with promising therapeutic potential, but with some contradictory results. Event related potentials are used as a marker of brain deterioration and can be used to evaluate TBS-related cognitive performance, but its use remains scant. This study aimed to study bilateral inhibitory and excitatory TBS effects upon neurocognitive performance of young healthy volunteers, using the auditory P300' results. Using a double-blind sham-controlled study, 51 healthy volunteers were randomly assigned to five different groups, two submitted to either excitatory (iTBS) or inhibitory (cTBS) stimulation over the left dorsolateral pre-frontal cortex (DLPFC), two other actively stimulated the right DLPFC and finally a sham stimulation group...
2018: PloS One
https://www.readbyqxmd.com/read/29290657/diagnostic-classification-of-endosonography-for-differentiating-colorectal-ulcerative-diseases-a-new-statistical-method
#15
En-Qi Qiu, Wen Guo, Tian-Ming Cheng, Yong-Li Yao, Wei Zhu, Si-De Liu, Fa-Chao Zhi
AIM: To establish a classification method for differential diagnosis of colorectal ulcerative diseases, especially Crohn's disease (CD), primary intestinal lymphoma (PIL) and intestinal tuberculosis (ITB). METHODS: We searched the in-patient medical record database for confirmed cases of CD, PIL and ITB from 2008 to 2015 at our center, collected data on endoscopic ultrasound (EUS) from randomly-chosen patients who formed the training set, conducted univariate logistic regression analysis to summarize EUS features of CD, PIL and ITB, and created a diagnostic classification method...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29249365/comparative-study-of-ipsilesional-and-contralesional-repetitive-transcranial-magnetic-stimulations-for-acute-infarction
#16
Kosuke Watanabe, Yosuke Kudo, Eriko Sugawara, Tomoki Nakamizo, Kazumitsu Amari, Koji Takahashi, Osamu Tanaka, Miho Endo, Yuko Hayakawa, Ken Johkura
BACKGROUND AND PURPOSE: Repetitive transcranial magnetic stimulation (rTMS) is reported to improve chronic post-stoke hemiparesis. However, application of rTMS during the acute phase of post-stroke has not fully been investigated. We investigated the safety and the efficacy of intermittent theta-burst stimulation (iTBS) of the affected motor cortex and 1-Hz stimulation of the unaffected hemisphere during the acute phase in patients with hemiparesis due to capsular infarction. METHODS: Twenty one patients who met the study criteria were randomly assigned to receive, starting within 7days after stroke onset and for a period of 10days, iTBS of the affected motor cortex hand area (n=8), 1-Hz stimulation of the unaffected motor cortex hand area (n=7), or sham stimulation (n=6)...
January 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29236921/intermittent-theta-burst-transcranial-magnetic-stimulation-for-autism-spectrum-disorder-an-open-label-pilot-study
#17
Caio Abujadi, Paul E Croarkin, Bianca B Bellini, Helena Brentani, Marco A Marcolin
OBJECTIVE: Theta-burst stimulation (TBS) modulates synaptic plasticity more efficiently than standard repetitive transcranial magnetic stimulation delivery and may be a promising modality for neuropsychiatric disorders such as autism spectrum disorder (ASD). At present there are few effective interventions for prefrontal cortex dysfunction in ASD. We report on an open-label, pilot study of intermittent TBS (iTBS) to target executive function deficits and restricted, repetitive behaviors in male children and adolescents with ASD...
December 11, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29205485/combination-of-increased-visceral-fat-and-long-segment-involvement-development-and-validation-of-an-updated-imaging-marker-for-differentiating-crohn-s-disease-from-intestinal-tuberculosis
#18
Saurabh Kedia, K S Madhusudhan, Raju Sharma, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Prasenjit Das, Siddhartha Dattagupta, Govind Makharia, Vineet Ahuja
BACKGROUND: Computed tomographic(CT) features(long segment, ileocaecal area involvement and lymph nodes>1cm) have demonstrated good specificity but poor sensitivity, while visceral to subcutaneous fat ratio on CT(VF/SC>0.63) has moderate sensitivity and specificity in differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB). AIM: To develop and validate an updated model incorporating CT features and VF/SC to improve the diagnostic accuracy of imaging in differentiating CD/ITB...
December 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29192855/early-outcomes-after-intrathecal-baclofen-therapy-in-ambulatory-patients-with-multiple-sclerosis
#19
Bryan S Lee, Jaes Jones, Min Lang, Rebecca Achey, Lu Dai, Darlene A Lobel, Sean J Nagel, Andre G Machado, Francois Bethoux
OBJECTIVE Multiple sclerosis (MS) is a chronic autoimmune disease that causes demyelination and axonal loss. Walking difficulties are a common and debilitating symptom of MS; they are usually caused by spastic paresis of the lower extremities. Although intrathecal baclofen (ITB) therapy has been reported to be an effective treatment for spasticity in MS, there is limited published evidence regarding its effects on ambulation. The goal of this study was to characterize ITB therapy outcomes in ambulatory patients with MS...
December 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29178837/vispa2-a-scalable-pipeline-for-high-throughput-identification-and-annotation-of-vector-integration-sites
#20
Giulio Spinozzi, Andrea Calabria, Stefano Brasca, Stefano Beretta, Ivan Merelli, Luciano Milanesi, Eugenio Montini
BACKGROUND: Bioinformatics tools designed to identify lentiviral or retroviral vector insertion sites in the genome of host cells are used to address the safety and long-term efficacy of hematopoietic stem cell gene therapy applications and to study the clonal dynamics of hematopoietic reconstitution. The increasing number of gene therapy clinical trials combined with the increasing amount of Next Generation Sequencing data, aimed at identifying integration sites, require both highly accurate and efficient computational software able to correctly process "big data" in a reasonable computational time...
November 25, 2017: BMC Bioinformatics
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