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https://www.readbyqxmd.com/read/28990718/limb-sparing-sarcoma-reconstruction-with-functional-composite-thigh-flaps
#1
John T Stranix, Z-Hye Lee, Gretl Lam, Joshua Mirrer, Timothy Rapp, Pierre B Saadeh
INTRODUCTION: Innervated muscle transfer can improve functional outcomes after extensive limb-sparing sarcoma resections. We report our experience using composite thigh flaps for functional reconstruction of large oncologic extremity defects. PATIENTS AND METHODS: Between 2011 and 2014, four limb-sparing oncologic resections (3 lower extremities, 1 upper extremity) underwent immediate functional reconstruction with composite thigh free flaps in three males and one female...
October 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28974897/temporal-trends-in-the-misdiagnosis-rates-between-crohn-s-disease-and-intestinal-tuberculosis
#2
Hyungil Seo, Seohyun Lee, Hoonsub So, Donghoi Kim, Seon-Ok Kim, Jae Seung Soh, Jung Ho Bae, Sun-Ho Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
AIM: To investigate the temporal trends in the misdiagnosis rate between Crohn's disease (CD) and intestinal tuberculosis (ITB) in South Korea. METHODS: We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB (final CD group) and vice versa (final ITB group)...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28970120/an-anatomic-study-of-trifurcate-iliotibial-bands-for-correcting-valgus-knee-deformity
#3
Yu-Hang Zhu, Qin-Li Xu, Guo-Dong Liang, Yun-Tao Wu, You-Qiong Li, Qing-San Zhu
BACKGROUND: The iliotibial band (ITB) trifurcates into the anterior, central and posterior branches at the knee level, and sometimes the branches must be selectively released to correct the valgus knee deformity during total knee arthroplasty. However, the anatomical morphology of the trifurcate ITBs has not been investigated. METHODS: Fifty-two knees from 26 embalmed cadavers were dissected to observe and record the relationship of the three branches given off from the ITB trifurcation...
September 29, 2017: Knee
https://www.readbyqxmd.com/read/28964670/intrathecal-baclofen-treatment-an-option-in-x-linked-adrenoleukodystrophy
#4
Helgi Thor Hjartarson, Christoffer Ehrstedt, Kristina Tedroff
BACKGROUND: X-linked adrenoleukodystrophy (X-ALD) is a genetic peroxisomal disorder associated with tissue accumulation of very long chain fatty acids (VLCFAs). In approximately one third of affected males, this causes progressive and irreversible damage to the brain white matter. Progress is often rapid with upper motor neuron damage leading to severe spasticity and dystonia. The increased muscle tone is frequently difficult to alleviate with oral drugs. Here, we describe two patients with X-ALD who have received treatment with intrathecal baclofen pumps (ITB)...
September 14, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28947393/alterations-of-the-amplitude-of-low-frequency-fluctuation-in-healthy-subjects-with-theta-burst-stimulation-of-the-cortex-of-the-suprahyoid-muscles
#5
Xiuhang Ruan, Guangqing Xu, Cuihua Gao, Lingling Liu, Yanli Liu, Lisheng Jiang, Xin Chen, Shaode Yu, Xinqing Jiang, Yue Lan, Xinhua Wei
Theta burst stimulation (TBS) has emerged as a promising tool for the treatment of swallowing disorders; however, the short-term after-effects of brain activation induced by TBS remain unknown. Here, we measured the changes in spontaneous brain activation using the amplitude of low-frequency fluctuation (ALFF) approach in subjects who underwent different TBS protocols. Sixty right-handed healthy participants (male, n=30; female, n=30; mean age=23.5y) were recruited in this study and randomly assigned to three groups that underwent three different TBS protocols...
September 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28937248/theta-burst-stimulation-in-the-treatment-of-chronic-orofacial-pain-a-randomized-controlled-trial
#6
B Kohútová, J Fricová, M Klírová, T Novák, R Rokyta
Theta burst stimulation (TBS) is a modified form of high-frequency repetitive transcranial magnetic stimulation (rTMS) with promising effect in chronic pain. The aim of our double-blind, sham-controlled, parallel-group, randomized study was to assess an efficacy of intermittent TBS (iTBS) in the treatment of patients with chronic orofacial pain. Nineteen patients (twelve females) with chronic orofacial pain were prospectively included and randomly assigned to single session of an active (iTBS) or sham (intermediate TBS; imTBS) stimulation delivered to the primary motor cortex (M1) contralateral to painful side...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28879772/brain-membrane-proteome-and-phosphoproteome-reveal-molecular-basis-associating-with-nursing-and-foraging-behaviors-of-honeybee-workers
#7
Bin Han, Yu Fang, Mao Feng, Han Hu, Yue Hao, Chuan Ma, Xinmei Huo, Lifeng Meng, Xufeng Zhang, Fan Wu, Jianke Li
The brain is a vital organ in regulating complex social behaviors of honeybees including learning and memory. Knowledge of how brain membrane proteins and their phosphorylation underlie the age-related behavioral polyethism is still lacking. A hitherto age-resolved brain membrane proteome and phosphoproteome were reported in adult worker bees from two strains of honeybee (Apis mellifera ligustica): Italian bee (ITB) and Royal Jelly bee (RJB), a line selected from ITB for increased RJ outputs over four decades...
September 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28871222/reproducibility-of-single-pulse-paired-pulse-and-intermittent-theta-burst-tms-measures-in-healthy-aging-type-2-diabetes-and-alzheimer-s-disease
#8
Peter J Fried, Ali Jannati, Paula Davila-Pérez, Alvaro Pascual-Leone
Background: Transcranial magnetic stimulation (TMS) can be used to assess neurophysiology and the mechanisms of cortical brain plasticity in humans in vivo. As the use of these measures in specific populations (e.g., Alzheimer's disease; AD) increases, it is critical to understand their reproducibility (i.e., test-retest reliability) in the populations of interest. Objective: Reproducibility of TMS measures was evaluated in older adults, including healthy, AD, and Type-2 diabetes mellitus (T2DM) groups. Methods: Participants received two identical neurophysiological assessments within a year including motor thresholds, baseline motor evoked potentials (MEPs), short- and long-interval intracortical inhibition (SICI, LICI) and intracortical facilitation (ICF), and MEP changes following intermittent theta-burst stimulation (iTBS)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28867993/impact-of-prefrontal-theta-burst-stimulation-on-clinical-neuropsychological-tasks
#9
Raquel Viejo-Sobera, Diego Redolar-Ripoll, Mercè Boixadós, Marc Palaus, Antoni Valero-Cabré, Elena M Marron
Theta burst stimulation (TBS) protocols hold high promise in neuropsychological rehabilitation. Nevertheless, their ability to either decrease (continuous, cTBS) or increase (intermittent, iTBS) cortical excitability in areas other than the primary motor cortex, and their consistency modulating human behaviors with clinically relevant tasks remain to be fully established. The behavioral effects of TBS over the dorsolateral prefrontal cortex (dlPFC) are particularly interesting given its involvement in working memory (WM) and executive functions (EF), often impaired following frontal brain damage...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28866663/infections-of-intrathecal-baclofen-delivery-systems-and-ventriculoperitoneal-shunting-systems-clinical-series-discussion
#10
Oussama Abousamra, Maria Del Pilar Duque Orozco, Kenneth J Rogers, Freeman Miller, Julieanne P Sees
BACKGROUND/AIMS: The physiological interaction between the intrathecal baclofen (ITB) delivery system and the ventriculoperitoneal (VP) shunting system in a patient who had both systems implanted has not been reported previously. The aim of our report is to evaluate the effect that one system's infection might have on the other. METHODS: Records of children who were followed at our institution between 2004 and 2015 for management of their ITB systems were reviewed...
September 2, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28864947/immortal-time-bias-in-pharmacoepidemiological-studies-on-cancer-patient-survival-empirical-illustration-for-beta-blocker-use-in-four-cancers-with-different-prognosis
#11
Janick Weberpals, Lina Jansen, Myrthe P P van Herk-Sukel, Josephina G Kuiper, Mieke J Aarts, Pauline A J Vissers, Hermann Brenner
Immortal time bias (ITB) is still seen frequently in medical literature. However, not much is known about this bias in the field of cancer (pharmaco-)epidemiology. In context of a hypothetical beneficial beta-blocker use among cancer patients, we aimed to demonstrate the magnitude of ITB among 9876 prostate, colorectal, lung and pancreatic cancer patients diagnosed between 1998 and 2011, which were selected from a database linkage of the Netherlands Cancer Registry and the PHARMO Database Network. Hazard ratios (HR) and 95% confidence intervals from three ITB scenarios, defining exposure at a defined point after diagnosis (model 1), at any point after diagnosis (model 2) and as multiple exposures after diagnosis (model 3), were calculated to investigate the association between beta-blockers and cancer prognosis using Cox proportional hazards regression...
September 1, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28856488/tubercular-intestinal-strictures-show-a-poor-response-to-anti-tuberculous-therapy
#12
Piyush Aggarwal, Saurabh Kedia, Raju Sharma, Sawan Bopanna, Kumble Seetharama Madhusudhan, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Venigalla Pratap Mouli, Prasenjit Das, Siddhartha Dattagupta, Govind Makharia, Vineet Ahuja
BACKGROUND: The literature on resolution of intestinal strictures in patients with intestinal tuberculosis (ITB) after anti-tuberculous therapy (ATT) is sparse and ambivalent. We aimed to assess the frequency of stricture resolution after ATT and its predictors. METHODS: This ambispective cohort study included consecutive ITB patients with strictures who received ATT for ≥6 months and were on regular follow-up between January 2004 and December 2015. Resolution of stricture was assessed at the end of ATT by endoscopy/radiology...
October 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28834868/outcomes-of-intrathecal-baclofen-therapy-in-patients-with-cerebral-palsy-and-acquired-brain-injury
#13
Young Kwon Yoon, Kil Chan Lee, Han Eol Cho, Minji Chae, Jin Woo Chang, Won Seok Chang, Sung-Rae Cho
Intrathecal baclofen (ITB) has been known to reduce spasticity which did not respond to oral medications and botulinum toxin treatment. However, few results have been reported comparing the effects of ITB therapy in patients with cerebral palsy (CP) and acquired brain injury. This study aimed to investigate beneficial and adverse effects of ITB bolus injection and pump therapy in patients with CP and to compare outcomes to patients with acquired brain injury such as traumatic brain injury and hypoxic brain injury...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28817499/nurse-practitioner-lead-pediatric-baclofen-pump-program-impact-on-safety-and-quality-of-care
#14
Kristin Buxton, Ann Morgan, Jayne Rogers
Children with cerebral palsy experience spasticity that can be debilitating and cause significant pain and contractures. Intrathecal baclofen (ITB) therapy can help relieve this spasticity and improve the quality of life for these patients, but it comes with risk. Withdrawal from the medication in case of abrupt discontinuation of delivery can be life-threatening. Regular maintenance of the system is mandatory. Having a program in place to manage the device and support patients helps to ensure their safety...
August 16, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28803750/motor-cortex-and-spinal-cord-neuromodulation-promote-corticospinal-tract-axonal-outgrowth-and-motor-recovery-after-cervical-contusion-spinal-cord-injury
#15
N Zareen, M Shinozaki, D Ryan, H Alexander, A Amer, D Q Truong, N Khadka, A Sarkar, S Naeem, M Bikson, J H Martin
Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimulation of motor cortex to promote CST axonal sprouting and cathodal trans-spinal direct current stimulation (tsDCS) to enhance spinal cord activation to motor cortex stimulation after injury. We used Finite Element Method (FEM) modeling to direct tsDCS to the cervical enlargement...
November 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28789872/mechanical-analysis-of-extra-articular-knee-ligaments-part-two-tendon-grafts-used-for-knee-ligament-reconstruction
#16
Kristof Smeets, Johan Bellemans, Lennart Scheys, Bert O Eijnde, Joshua Slane, Steven Claes
OBJECTIVES: The aim of this study was to provide information about the mechanical properties of grafts used for knee ligament reconstructions and to compare those results with the mechanical properties of native knee ligaments. METHODS: Eleven cadaveric knees were dissected for the semitendinosus, gracilis, iliotibial band (ITB), quadriceps and patellar tendon. Uniaxial testing to failure was performed using a standardized method and mechanical properties (elastic modulus, ultimate stress, ultimate strain, strain energy density) were determined...
August 5, 2017: Knee
https://www.readbyqxmd.com/read/28789578/accelerated-itbs-treatment-in-depressed-patients-differentially-modulates-reward-system-activity-based-on-anhedonia
#17
Romain Duprat, Guo-Rong Wu, Rudi De Raedt, Chris Baeken
OBJECTIVES: Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDD patients. METHODS: In this registered RCT (NCT01832805), 50 MDD patients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC)...
August 9, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28695932/luminescent-lanthanide-metal-organic-frameworks-for-chemical-sensing-and-toxic-anion-detection
#18
Rui-Zhi Wu, Xing Yang, Liang-Wei Zhang, Pan-Pan Zhou
Prototype lanthanide metal-organic frameworks (LnMOFs), Ln(BTC) (Ln = Eu and Tb; BTC = benzene-1,3,5-tricarboxylate), have been considered as luminescent sensors for detecting toxic anions, while their neutral pore structures have limited the entrance and encapsulation of anions to produce highly anion-responsive photoluminescence (PL). To facilitate anions to enter the pore space of Ln(BTC), a one-pot synthesis method was proposed in which BTC was partially replaced with its structural analogue L·BF4 (H3L·BF4 = 2,4,6-tricarboxy-1-methylpyridinium tetrafluoroborate) which consists of an anion affinity site of cationic methylpyridinium...
July 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28682807/development-and-validation-of-a-novel-prediction-model-for-differential-diagnosis-between-crohn-s-disease-and-intestinal-tuberculosis
#19
Jung Ho Bae, Sang Hyoung Park, Byong Duk Ye, Seon-Ok Kim, Yun Kyung Cho, Eun Ja Youn, Ho-Su Lee, Sung Wook Hwang, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
BACKGROUND: Although colonoscopy is useful for differentiating between Crohn's disease (CD) and intestinal tuberculosis (ITB), the technique has limitations. We developed a practical prediction model for differentiating between CD and ITB using laboratory and radiologic parameters and colonoscopic characteristics. METHODS: We prospectively enrolled 80 patients newly diagnosed with CD (n = 40) and ITB (n = 40). We developed a new prediction score by integrating colonoscopic, laboratory, and radiologic parameters...
September 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28670609/symptomatic-isolated-terminal-ileal-ulcers-etiology-and-clinical-significance
#20
Varun Mehta, Ankita Gupta, Ramit Mahajan, Vikram Narang, Vandana Midha, Neena Sood, Harpreet Kaur, Kirandeep Kaur, Ajit Sood
BACKGROUND:  With an increasing number of ileal intubations, isolated terminal ileal ulcers (ITIU) are frequently found during colonoscopies. The present study aimed at studying the etiology and clinical significance of these ulcers in patients having gastrointestinal symptoms. METHODS:  This was a prospective observational study performed on consecutive patients who underwent ileocolonoscopy for various gastrointestinal symptoms between 1 January 2014 and 31 December 2014...
July 2017: Endoscopy International Open
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