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https://www.readbyqxmd.com/read/27903018/intrathecal-baclofen-therapy-for-the-treatment-of-spasticity-in-lithuania
#1
Robertas Kvascevicius, Ona Lapteva, Jurate Kesiene, Alfredas Vaitkus, Laima Mikulenaite, Ramunas Raugalas, Jurate Sipylaite, Saulius Rocka, Alvydas Juocevicius
Spasticity of cerebral or spinal origin severely impairs an individual's functional ability and quality of life. Intrathecal baclofen (ITB) therapy via an implantable pump is indicated for use in patients unresponsive to oral antispasmodics. ITB therapy improves the daily caring for and relief of painful spasms. In Lithuania, ITB therapy was introduced in clinical practice just recently. We share our experience of spasticity management with the ITB pump system in five patients at Vilnius University Hospital Santariskiu Klinikos...
November 30, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27900437/bdnf-and-ltp-ltd-like-plasticity-of-the-primary-motor-cortex-in-gilles-de-la-tourette-syndrome
#2
L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini, F Cardona, G Defazio, A Berardelli
Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects...
November 30, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27891316/histologic-and-histomorphometric-evaluation-of-two-grafting-materials-cenobone-and-itb-mba-in-open-sinus-lift-surgery
#3
Babak Amoian, Maryam Seyedmajidi, Hamidreza Safipor, Sediqe Ebrahimipour
AIMS AND OBJECTIVES: Alveolar ridge reduction caused after tooth extraction can be minimized through ridge preservation and application of graft materials. The aim of this study was to compare the histologic and histomorphometric aspects of bone particulated allografts, Cenobone and ITB-MBA, in the reconstruction of vertical alveolar ridge after maxillary sinus augmentation. MATERIALS AND METHODS: This clinical trial was performed among 20 patients. The participants were randomly divided into two groups of 10 participants...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27888026/priming-theta-burst-stimulation-enhances-motor-cortex-plasticity-in-young-but-not-old-adults
#4
George M Opie, Eleni Vosnakis, Michael C Ridding, Ulf Ziemann, John G Semmler
BACKGROUND: Primary motor cortex (M1) neuroplasticity is reduced in old adults, which may contribute to the motor deficits commonly observed in the elderly. Previous research in young subjects suggests that the neuroplastic response can be enhanced using non-invasive brain stimulation (NIBS), with a larger plastic response observed following priming with both long-term potentiation (LTP) and depression (LTD)-like protocols. However, it is not known if priming stimulation can also modulate plasticity in older adults...
November 17, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27831916/retrospective-evaluation-of-the-clinical-utility-of-serological-biomarkers-in-chinese-patients-with-inflammatory-bowel-disease-2-year-clinical-experience
#5
Shulan Zhang, Jing Luo, Ji Li, Ziyan Wu, Chaojun Hu, Ping Li, Chuiwen Deng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
BACKGROUND: Antibodies to saccharomyces cerevisiae (ASCA), antibodies to perinuclear anti-neutrophil cytoplasmic (pANCA), pancreatic autoantibodies (PAB) and antibodies against intestinal goblet cells (GAB) are important in diagnosing Crohn's disease (CD) and ulcerative colitis (UC). However, little is known about their diagnostic value in real clinical practice in China. This retrospective study aimed to present our 2-year clinical experience with those biomarkers in diagnosis of CD and UC...
November 10, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27801405/-the-application-of-high-frequency-and-itbs-transcranial-magnetic-stimulation-for-the-treatment-of-spasticity-in-the-patients-presenting-with-secondary-progressive-multiple-sclerosis
#6
Yu E Korzhova, A V Chervyakov, A G Poidasheva, I A Kochergin, A V Peresedova, M N Zakharova, N A Suponeva, L A Chernikova, M A Piradov
: Spasticity is considered to be a common manifestation of multiple sclerosis. Muscle relaxants are not sufficiently effective; more than that, some of them often cause a variety of adverse reactions. Transcranial magnetic stimulation (TMS) can be a promising new tool for the treatment of spasticity. The objective of the present study was to compare the effectiveness of the two TMS protocols: rhythmic (high-frequency) TMS (rTMS) and stimulation with the theta bursts (iTBS) in terms of their ability to reduce spasticity in the patients presenting with multiple sclerosis...
2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/27796359/cerebellar-theta-burst-stimulation-modulates-the-neural-activity-of-interconnected-parietal-and-motor-areas
#7
Elias Paolo Casula, Maria Concetta Pellicciari, Viviana Ponzo, Mario Stampanoni Bassi, Domenica Veniero, Carlo Caltagirone, Giacomo Koch
Voluntary movement control and execution are regulated by the influence of the cerebellar output over different interconnected cortical areas, through dentato-thalamo connections. In the present study we applied transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to directly assess the effects of cerebellar theta-burst stimulation (TBS) over the controlateral primary motor cortex (M1) and posterior parietal cortex (PPC) in a group of healthy volunteers. We found a TBS-dependent bidirectional modulation over TMS-evoked activity; specifically, cTBS increased whereas iTBS decreased activity between 100 and 200 ms after TMS, in a similar manner over both M1 and PPC areas...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27766073/differences-in-motor-evoked-potentials-induced-in-rats-by-transcranial-magnetic-stimulation-under-two-separate-anesthetics-implications-for-plasticity-studies
#8
Matthew Sykes, Natalie A Matheson, Philip W Brownjohn, Alexander D Tang, Jennifer Rodger, Jonathan B H Shemmell, John N J Reynolds
Repetitive transcranial magnetic stimulation (rTMS) is primarily used in humans to change the state of corticospinal excitability. To assess the efficacy of different rTMS stimulation protocols, motor evoked potentials (MEPs) are used as a readout due to their non-invasive nature. Stimulation of the motor cortex produces a response in a targeted muscle, and the amplitude of this twitch provides an indirect measure of the current state of the cortex. When applied to the motor cortex, rTMS can alter MEP amplitude, however, results are variable between participants and across studies...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27748671/intermittent-%C3%AE-burst-stimulation-modulates-resting-state-functional-connectivity-in-the-attention-network-and-promotes-behavioral-recovery-in-patients-with-visual-spatial-neglect
#9
Lei Cao, Wei Fu, Yanming Zhang, Su Huo, JuBao Du, Lin Zhu, Weiqun Song
Functional connectivity changes in the attention network are viewed as a physiological signature of visual spatial neglect (VSN). The left dorsal lateral prefrontal cortex (LDLPFC) is known to initiate and monitor top-down attentional control and dynamically adjust behavioral performance. This study aimed to investigate whether increasing the activity of the LDLPFC through intermittent θ burst stimulation (iTBS) could modulate the resting-state functional connectivity in the attention network and facilitate recovery from VSN...
September 29, 2016: Neuroreport
https://www.readbyqxmd.com/read/27746490/iliotibial-band-syndrome-following-hip-arthroscopy-an-unreported-complication
#10
Roberto Seijas, Andrea Sallent, María Galán, Pedro Alvarez-Diaz, Oscar Ares, Ramón Cugat
BACKGROUND: Hip arthroscopy is considered a safe procedure, considering the relatively low rate of complications. Despite several complications have been described following this surgical procedure, the present event has not yet been described. The purpose of the present study is to report an unpublished complication following hip arthroscopy, after reviewing 162 hip arthroscopies and finding iliotibial band syndrome (ITBS) in the knee during followup. MATERIALS AND METHODS: A retrospective review of 162 hip arthroscopies performed between September 2007 and June 2011 was carried out, evaluating patients who presented ITBS during followup...
September 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27729854/accelerated-intermittent-theta-burst-stimulation-for-suicide-risk-in-therapy-resistant-depressed-patients-a-randomized-sham-controlled-trial
#11
Stefanie Desmyter, Romain Duprat, Chris Baeken, Sara Van Autreve, Kurt Audenaert, Kees van Heeringen
Objectives: We aimed to examine the effects and safety of accelerated intermittent Theta Burst Stimulation (iTBS) on suicide risk in a group of treatment-resistant unipolar depressed patients, using an extensive suicide assessment scale. Methods: In 50 therapy-resistant, antidepressant-free depressed patients, an intensive protocol of accelerated iTBS was applied over the left dorsolateral prefrontal cortex (DLPFC) in a randomized, sham-controlled crossover design. Patients received 20 iTBS sessions over 4 days...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27692927/effects-of-theta-burst-stimulation-on-suprahyoid-motor-cortex-excitability-in-healthy-subjects
#12
Tuo Lin, Lisheng Jiang, Zulin Dou, Cheng Wu, Feng Liu, Guangqing Xu, Yue Lan
BACKGROUND: Continuous theta burst stimulation (cTBS) and intermittent TBS (iTBS) are powerful patterns of repetitive transcranial magnetic stimulation (rTMS), with substantial potential for motor function rehabilitation post-stroke. However, TBS of suprahyoid motor cortex excitability has not been investigated. This study investigated TBS effects on suprahyoid motor cortex excitability and its potential mechanisms in healthy subjects. METHODS: Thirty-five healthy subjects (23 females; mean age = 21...
August 24, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27664997/the-first-meeting-of-the-who-guideline-development-group-for-the-revision-of-the-who-1999-guidelines-for-iodine-thyroid-blocking
#13
Christoph Reiners, Rita Schneider, Makoshi Akashi, Eli A Akl, Jean-René Jourdain, Chunsheng Li, Christoph Murith, Lodewijk Van Bladel, Shunichi Yamashita, Hajo Zeeb, Paolo Vitti, Zhanat Carr
The meeting held in May 2014 in Würzburg, Germany, discussed the scope of the revision of the 1999 WHO guidelines for iodine thyroid blocking (ITB) by following the WHO handbook for guideline development. This article describes the process and methods of developing the revised, evidence-based WHO guidelines for ITB following nuclear and radiological accidents, the results of the kick-off meeting as well as further steps taken to complete the revision.
September 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27662848/segond-fracture-an-mr-evaluation-of-146-patients-with-emphasis-on-the-avulsed-bone-fragment-and-what-attaches-to-it
#14
Dyan V Flores, Edward Smitaman, Brady K Huang, Donald L Resnick
OBJECTIVE: To re-evaluate the Segond fragment emphasizing those structures that attach to the fragment in patients with reported acute/subacute anterior cruciate ligament (ACL) injuries, and to clarify the nomenclature used to describe these structures. MATERIALS AND METHODS: A search of databases of knee MR examinations over 4.5 years with reported ACL tears yielded 19,726 studies. Using strict exclusion criteria, a total of 146 MR studies with acute/subacute ACL tears were re-assessed with respect to the Segond fragment's size, shape, orientation, location, displacement, attaching soft tissue structures, and associated osseous and/or soft tissue injuries...
September 24, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27651067/targeted-transcranial-theta-burst-stimulation-alters-fronto-insular-network-and-prefrontal-gaba
#15
Sarina J Iwabuchi, Felix Raschke, Dorothee P Auer, Peter F Liddle, Sudheer T Lankappa, Lena Palaniyappan
Repetitive transcranial magnetic stimulation (rTMS) has been used worldwide to treat depression. However, the exact physiological effects are not well understood. Pathophysiology of depression involves crucial limbic structures (e.g. insula), and it is still not clear if these structures can be modulated through neurostimulation of surface regions (e.g. dorsolateral prefrontal cortex, DLPFC), and whether rTMS-induced excitatory/inhibitory transmission alterations relate to fronto-limbic connectivity changes...
September 17, 2016: NeuroImage
https://www.readbyqxmd.com/read/27636847/humans-with-type-2-diabetes-show-abnormal-long-term-potentiation-like-cortical-plasticity-associated-with-verbal-learning-deficits
#16
Peter J Fried, Lukas Schilberg, Anna-Katharine Brem, Sadhvi Saxena, Bonnie Wong, Aaron M Cypess, Edward S Horton, Alvaro Pascual-Leone
BACKGROUND: Type-2 diabetes mellitus (T2DM) accelerates cognitive aging and increases risk of Alzheimer's disease. Rodent models of T2DM show altered synaptic plasticity associated with reduced learning and memory. Humans with T2DM also show cognitive deficits, including reduced learning and memory, but the relationship of these impairments to the efficacy of neuroplastic mechanisms has never been assessed. OBJECTIVE: Our primary objective was to compare mechanisms of cortical plasticity in humans with and without T2DM...
September 13, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27623095/transcranial-theta-burst-stimulation-alters-glt-1-and-vglut1-expression-in-rat-cerebellar-cortex
#17
Bojana Mancic, Ivana Stevanovic, Tihomir V Ilic, Ana Djuric, Ivana Stojanovic, Sladjan Milanovic, Milica Ninkovic
Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittent and continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma...
September 10, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27619658/theta-burst-stimulation-over-premotor-cortex-in-parkinson-s-disease-an-explorative-study-on-manual-dexterity
#18
Tim Vanbellingen, Manuela Wapp, Katharina Stegmayer, Manuel Bertschi, Eugenio Abela, Stefanie Kübel, Thomas Nyffeler, René Müri, Sebastian Walther, Tobias Nef, Mark Hallett, Stephan Bohlhalter
Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson's disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with one train of TBS in three experimental sessions: sham stimulation over vertex, continuous TBS (cTBS) over PMd and intermittent TBS (iTBS) over PMd, respectively...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27602250/intrathecal-baclofen-therapy-for-spasticity-a-compliance-based-study-to-indicate-effectiveness
#19
Hussam Abou Al-Shaar, Ahmed Alkhani
BACKGROUND: Intrathecal baclofen (ITB) therapy using a programmable battery-based pump is a well-recognized option in the treatment of patients with refractory spasticity. Improvements in clinical scale scores for muscle spasticity among this heterogeneous group of patients may not reflect the functional benefits of this therapeutic option. The aim of our study is to report the efficacy of ITB therapy by setting the patient's compliance at the 2-year follow-up after pump implantation as an indicator of treatment efficacy, as appreciated by the patients or their caregivers...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27568058/low-intensity-repetitive-magnetic-stimulation-lowers-action-potential-threshold-and-increases-spike-firing-in-layer-5-pyramidal-neurons-in-vitro
#20
Alexander D Tang, Ivan Hong, Laura J Boddington, Andrew R Garrett, Sarah Etherington, John N J Reynolds, Jennifer Rodger
Repetitive transcranial magnetic stimulation (rTMS) has become a popular method of modulating neural plasticity in humans. Clinically, rTMS is delivered at high intensities to modulate neuronal excitability. While the high-intensity magnetic field can be targeted to stimulate specific cortical regions, areas adjacent to the targeted area receive stimulation at a lower intensity and may contribute to the overall plasticity induced by rTMS. We have previously shown that low-intensity rTMS induces molecular and structural plasticity in vivo, but the effects on membrane properties and neural excitability have not been investigated...
October 29, 2016: Neuroscience
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