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https://www.readbyqxmd.com/read/29787437/liquid-biopsy-using-whole-blood-from-testis-tumor-and-colon-cancer-patients-a-new-and-simple-way
#1
Matthäus Majewski, Tim Nestler, Sebastian Kägler, Ines Richardsen, Christian G Ruf, Cord Matthies, Arnulf Willms, Hans-Ulrich Schmelz, Walter Wagner, Robert Schwab, Michael Abend
Tumor cells shed exosomes, which are released to the blood. Detecting tumor-derived exosomes containing RNA in plasma (liquid biopsy) is currently being investigated for early identification of occult metastases or relapses. Isolation of exosomes is laborious, resulting in low RNA yields. As a more robust (but less sensitive) alternative, the authors examined whether whole blood can be used as well. Tumor samples from nonmetastasized seminoma (n = 5) and colon cancer patients (n = 6) were taken during surgery...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29770368/multi-label-inductive-matrix-completion-for-joint-mgmt-and-idh1-status-prediction-for-glioma-patients
#2
Lei Chen, Han Zhang, Kim-Han Thung, Luyan Liu, Junfeng Lu, Jinsong Wu, Qian Wang, Dinggang Shen
MGMT promoter methylation and IDH1 mutation in high-grade gliomas (HGG) have proven to be the two important molecular indicators associated with better prognosis. Traditionally, the statuses of MGMT and IDH1 are obtained via surgical biopsy, which is laborious, invasive and time-consuming. Accurate presurgical prediction of their statuses based on preoperative imaging data is of great clinical value towards better treatment plan. In this paper, we propose a novel Multi-label Inductive Matrix Completion (MIMC) model, highlighted by the online inductive learning strategy, to jointly predict both MGMT and IDH1 statuses...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29764458/cone-beam-computed-tomography-in-implant-dentistry-recommendations-for-clinical-use
#3
Reinhilde Jacobs, Benjamin Salmon, Marina Codari, Bassam Hassan, Michael M Bornstein
BACKGROUND: In implant dentistry, three-dimensional (3D) imaging can be realised by dental cone beam computed tomography (CBCT), offering volumetric data on jaw bones and teeth with relatively low radiation doses and costs. The latter may explain why the market has been steadily growing since the first dental CBCT system appeared two decades ago. More than 85 different CBCT devices are currently available and this exponential growth has created a gap between scientific evidence and existing CBCT machines...
May 15, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29753683/evaluating-resective-surgery-targets-in-epilepsy-patients-a-comparison-of-quantitative-eeg-methods
#4
Michael Müller, Kaspar Schindler, Marc Goodfellow, Claudio Pollo, Christian Rummel, Andreas Steimer
BACKGROUND: Quantitative analysis of intracranial EEG is a promising tool to assist clinicians in the planning of resective brain surgery in patients suffering from pharmacoresistant epilepsies. Quantifying the accuracy of such tools, however, is nontrivial as a ground truth to verify predictions about hypothetical resections is missing. NEW METHOD: As one possibility to address this, we use customized hypotheses tests to examine the agreement of the methods on a common set of patients...
May 10, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29746544/free-water-modeling-of-peritumoral-edema-using-multi-fiber-tractography-application-to-tracking-the-arcuate-fasciculus-for-neurosurgical-planning
#5
Shun Gong, Fan Zhang, Isaiah Norton, Walid I Essayed, Prashin Unadkat, Laura Rigolo, Ofer Pasternak, Yogesh Rathi, Lijun Hou, Alexandra J Golby, Lauren J O'Donnell
PURPOSE: Peritumoral edema impedes the full delineation of fiber tracts due to partial volume effects in image voxels that contain a mixture of cerebral parenchyma and extracellular water. The purpose of this study is to investigate the effect of incorporating a free water (FW) model of edema for white matter tractography in the presence of edema. MATERIALS AND METHODS: We retrospectively evaluated 26 consecutive brain tumor patients with diffusion MRI and T2-weighted images acquired presurgically...
2018: PloS One
https://www.readbyqxmd.com/read/29738857/the-effect-of-tumour-neovasculature-on-fmri-bold-activation
#6
Layla Gould, Chelsea Ekstrand, Daryl R Fourney, Marla J S Mickleborough, Tasha Ellchuk, Ron Borowsky
We report a 40-year-old patient with a large, WHO grade III oligodendroglioma in the left parietal lobe. Presurgical planning included fMRI localization of language, motor, and somatosensory processing. The fMRI results for the motor and somatosensory tasks revealed activation in peri-lesional regions near the surgical resection, as well as deactivation in the tumour for the sensory task, suggesting that there is decreased autoregulation in the region due to the glioma. The fMRI results showed left hemisphere dominance for language, as well as activation in peri-lesional regions for all three speech tasks (i...
May 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29733474/computed-tomographic-description-of-the-highly-variable-imaging-features-of-equine-oromaxillary-sinus-and-oronasal-fistulae
#7
Laura Hargreaves, Jonathon J Dixon
Oronasal and oromaxillary sinus fistulae are well-documented complications following removal or loss of a maxillary cheek tooth. Diagnosis is currently based on a combination of oral examination, videoendoscopy, radiography, and computed tomography (CT). The objective of this retrospective, case series study was to describe the CT characteristics of confirmed oronasal and oromaxillary sinus fistulae in a group of horses. Inclusion criteria were a head CT acquired at the authors' hospital during the period of 2012-2017, a CT diagnosis of oronasal or oromaxillary sinus fistulae, and a confirmed diagnosis based on a method other than CT...
May 7, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29685838/shear-wave-elastography-can-predict-passive-stiffness-of-supraspinatus-musculotendinous-unit-during-arthroscopic-rotator-cuff-repair-for-presurgical-planning
#8
Yoshiaki Itoigawa, Yuichiro Maruyama, Takayuki Kawasaki, Tomoki Wada, Keiichi Yoshida, Kai-Nan An, Kazuo Kaneko
PURPOSE: To determine the feasibility of shear wave elastography (SWE) with B-mode ultrasound in predicting the stiffness of the rotator cuff muscle before arthroscopic rotator cuff repair to evaluate the difficulty of the surgical procedure, as well as to compare SWE with the Goutallier stage on magnetic resonance imaging (MRI). METHODS: Thirty-eight patients with a full-thickness supraspinatus tear requiring arthroscopic rotator cuff repair participated. The Goutallier stage of fatty infiltration on MRI was measured before surgery, as was the SWE modulus of the anterior superficial, anterior deep, posterior superficial, and posterior deep (PD) regions of the supraspinatus muscle...
April 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29652234/computer-assisted-planning-for-the-insertion-of-stereoelectroencephalography-electrodes-for-the-investigation-of-drug-resistant-focal-epilepsy-an-external-validation-study
#9
Vejay N Vakharia, Rachel Sparks, Roman Rodionov, Sjoerd B Vos, Christian Dorfer, Jonathan Miller, Daniel Nilsson, Martin Tisdall, Stefan Wolfsberger, Andrew W McEvoy, Anna Miserocchi, Gavin P Winston, Aidan G O'Keeffe, Sebastien Ourselin, John S Duncan
OBJECTIVE One-third of cases of focal epilepsy are drug refractory, and surgery might provide a cure. Seizure-free outcome after surgery depends on the correct identification and resection of the epileptogenic zone. In patients with no visible abnormality on MRI, or in cases in which presurgical evaluation yields discordant data, invasive stereoelectroencephalography (SEEG) recordings might be necessary. SEEG is a procedure in which multiple electrodes are placed stereotactically in key targets within the brain to record interictal and ictal electrophysiological activity...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29626447/hemimandibular-hyperplasia-correction-by-simultaneous-orthognathic-surgery-and-condylectomy-under-digital-guidance
#10
Bing Han, Xing Wang, Zili Li, Biao Yi, Cheng Liang, Xiaoxia Wang
PURPOSE: Orthognathic surgery with simultaneous condylectomy under digital guidance has been proved to be a feasible method to treat hemimandibular hyperplasia (HH). The objective of this study was to evaluate the effects and precision of correction of HH by use of this method. PATIENTS AND METHODS: This was a case-series study. Fourteen patients with HH who had undergone simultaneous bimaxillary orthognathic surgery and condylectomy from January 2016 to April 2017 were included in this study...
March 15, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29616168/personalized-3d-printed-surgical-tool-for-guiding-the-chisel-during-hump-reduction-in-rhinoplasty
#11
Hugo Herrero Antón de Vez, Javier Herrero Jover, Claudio Silva-Vergara
The authors aimed to present an introduction of patient-specific model in rhinoplasty by introducing a 3D printed surgical guide designed and adapted in an individualized manner for guiding dorsal hump reduction. To introduce the tool, we have designed a six step workflow. First, we obtain a digital 3D model of patient anatomy using computed tomography (CT) images. Second, we conduct a surgical preoperative planning of the rhinoplasty on the mentioned model. Third step consists of designing the guide, while taking into account nasal anthropometries and resection objectives...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29596549/preoperative-facial-nerve-mapping-to-plan-and-guide-pediatric-facial-vascular-anomaly-resection
#12
Randall A Bly, Robert N Holdefer, Jefferson Slimp, Gregory A Kinney, Vicente Martinez, Scott C Manning, Jonathan A Perkins
Importance: Facial vascular anomalies are surgical challenges due to their vascularity and facial nerve distortion. To assist facial vascular anomaly surgical treatment, presurgical percutaneous facial nerve stimulation and recording of compound motor action potentials can be used to map the facial nerve branches. During surgery, the nerve map and continuous intraoperative motor end plate potential monitoring can be used to reduce nerve injury. Objective: To investigate if preoperative facial nerve mapping (FNM) is associated with intraoperative facial nerve injury risk and safe surgical approach options compared with standard nerve integrity monitoring (NIM)...
March 29, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29589954/validation-of-an-mri-protocol-for-routine-quantitative-assessment-of-tunnel-position-in-anterior-cruciate-ligament-reconstruction
#13
Samuel Grasso, James Linklater, Qing Li, David A Parker
BACKGROUND: No standardized methodology and objective criteria currently exist to accurately and objectively assess tunnel placement and consequent graft orientation in anterior cruciate ligament (ACL) reconstruction (ACLR) through a single imaging modality. Advances in magnetic resonance imaging (MRI) technology have enabled the use of volumetric high spatial and contrast resolution proton density-weighted sequencing, which allows precise delineation of graft orientation, tunnel position, and quantitative assessment of tunnel position relationship to adjacent reproducible anatomic landmarks...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29588945/seven-tesla-mri-improves-detection-of-focal-cortical-dysplasia-in-patients-with-refractory-focal-epilepsy
#14
Tim J Veersema, Cyrille H Ferrier, Pieter van Eijsden, Peter H Gosselaar, Eleonora Aronica, Fredy Visser, Jaco M Zwanenburg, Gerard A P de Kort, Jeroen Hendrikse, Peter R Luijten, Kees P J Braun
Objective: The aim of this study is to determine whether the use of 7 tesla (T) MRI in clinical practice leads to higher detection rates of focal cortical dysplasias in possible candidates for epilepsy surgery. Methods: In our center patients are referred for 7 T MRI if lesional focal epilepsy is suspected, but no abnormalities are detected at one or more previous, sufficient-quality lower-field MRI scans, acquired with a dedicated epilepsy protocol, or when concealed pathology is suspected in combination with MR-visible mesiotemporal sclerosis-dual pathology...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29587187/characteristics-and-healthcare-situation-of-adult-patients-with-tuberous-sclerosis-complex-in-german-epilepsy-centers
#15
Hajo M Hamer, Margarete Pfäfflin, Hartmut Baier, Frank Bösebeck, Melanie Franz, Martin Holtkamp, Gerhard Kurlemann, Theodor W May, Thomas Mayer, Mirjam Metzner, Bernhard J Steinhoff, Stefan Stodieck, Hans-Beatus Straub, Yvonne G Weber, Christian Brandt
OBJECTIVE: The objective of the present study was to collect systematic data on the care of adult patients with tuberous sclerosis complex (TSC) in German epilepsy centers, to describe the characteristics of patients in this age group, and to clarify whether and how the recommended interdisciplinary care is implemented. METHODS: This retrospective survey involved 12 major epilepsy centers in Germany. Aggregated data were collected based on an electronic questionnaire that addressed the sociodemographic data, characteristics of the epilepsy syndromes, and general healthcare setting of adult patients with TSC...
March 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29561756/diagnosis-and-surgical-treatment-of-drug-resistant-epilepsy
#16
REVIEW
Chinekwu Anyanwu, Gholam K Motamedi
Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory). Epilepsy surgery offers a potential cure or significant improvement to those with focal onset drug-resistant seizures. Unfortunately, epilepsy surgery is still underutilized which might be in part because of the complexity of presurgical evaluation. This process includes classifying the seizure type, lateralizing and localizing the seizure onset focus (epileptogenic zone), confirming the safety of the prospective brain surgery in terms of potential neurocognitive deficits (language and memory functions), before devising a surgical plan...
March 21, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29549813/surgery-of-language-eloquent-tumors-in-patients-not-eligible-for-awake-surgery-the-impact-of-a-protocol-based-on-navigated-transcranial-magnetic-stimulation-on-presurgical-planning-and-language-outcome-with-evidence-of-tumor-induced-intra-hemispheric-plasticity
#17
Giovanni Raffa, Maria C Quattropani, Antonino Scibilia, Alfredo Conti, Filippo Flavio Angileri, Felice Esposito, Carmela Sindorio, Salvatore Massimiliano Cardali, Antonino Germanò, Francesco Tomasello
OBJECTIVES: Awake surgery and intraoperative monitoring represent the gold standard for surgery of brain tumors located in the perisylvian region of the dominant hemisphere due to their ability to map and preserve the language network during surgery. Nevertheless, in some cases awake surgery is not feasible. This could increase the risk of postoperative language deficit. Navigated transcranial magnetic stimulation (nTMS) and nTMS-based DTI fiber tracking (DTI-FT) provide a preoperative mapping and reconstruction of the cortico-subcortical language network...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29541573/spontaneous-resolution-of-a-confounding-insular-lesion
#18
Ali S Haider, Christopher S Graffeo, Avital Perry, Lucas P Carlstrom, Terry C Burns
Insular gliomas were previously considered inoperable lesions and were typically treated via biopsy, chemotherapy and/or radiation, if not observation alone. Stereotactic biopsies of low grade insular gliomas can underestimate tumor grade or fail to establish malignancy. Moreover, the survival advantages of maximal safe resection for insular lesions are increasingly being recognized. As such, early surgical resection is increasingly being performed. As with most lesions, a differential diagnosis exists for apparent insular gliomas, with definitive diagnosis generally obtained upon resection...
January 11, 2018: Curēus
https://www.readbyqxmd.com/read/29533538/air-conducted-and-skull-tap-cervical-vestibular-evoked-myogenic-potentials-in-determining-nerve-division-involvement-in-vestibular-schwannoma-patients
#19
Magdalena Lachowska, Paulina Glinka, Kazimierz Niemczyk
BACKGROUND: Air-conducted and skull-tap cervical vestibular evoked myogenic potentials (AC-cVEMP and Tap-cVEMP) have been shown to be very promising tools in clinical practice. They are noninvasive, easy to obtain and - importantly - they require little time and the cost of the instruments is low. OBJECTIVES: The aim of this study was to evaluate the usefulness of the combined use of ACand Tap-cVEMPs as a diagnostic tool for advanced assessment of vestibular schwannoma in determining tumor origin, and to investigate whether the results are helpful for a surgeon as an additional source of information about the tumor before surgery...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29528160/presurgical-language-fmri-clinical-practices-and-patient-outcomes-in-epilepsy-surgical-planning
#20
Christopher F A Benjamin, Alexa X Li, Hal Blumenfeld, R Todd Constable, Rafeed Alkawadri, Stephan Bickel, Christoph Helmstaedter, Stefano Meletti, Richard Bronen, Simon K Warfield, Jurriaan M Peters, David Reutens, Monika Połczyńska, Dennis D Spencer, Lawrence J Hirsch
The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Respondents were predominantly US (61%) academic programs (85%), and evaluated adults (44%), adults and children (40%), or children only (16%). Nearly all (96%) reported using language fMRI. Surprisingly, fMRI is used to guide surgical margins (44% of programs) as well as lateralize language (100%)...
March 12, 2018: Human Brain Mapping
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