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https://www.readbyqxmd.com/read/27908155/a-new-algorithm-for-estimating-the-rod-volume-fraction-and-the-trabecular-thickness-from-in-vivo-computed-tomography
#1
Felix Sebastian Leo Thomsen, Jaime Andrés Peña, Yongtao Lu, Gerd Huber, Michael Morlock, Claus-Christian Glüer, Claudio Augusto Delrieux
PURPOSE: Existing microstructure parameters are able to predict vertebral in vitro failure load, but for noisy in vivo data more complex algorithms are needed for a robust assessment. METHODS: A new algorithm is proposed for the microstructural analysis of trabecular bone under in vivo quantitative computed tomography (QCT). Five fractal parameters are computed: (1) the average local fractal dimension FD, (2) its standard deviation FD.SD, (3) the fractal rod volume ratio fRV/BV, (4) the average fractal trabecular thickness fTb...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27902847/food-deprivation-facilitates-reinstatement-of-morphine-induced-conditioned-place-preference-role-of-intra-accumbal-dopamine-d2-like-receptors-in-associating-reinstatement-of-morphine-cpp-with-stress
#2
Fatemeh Sadeghzadeh, Vahab Babapour, Abbas Haghparast
The high rate of relapse to drug use is one of the main problems in the treatment of addiction. Stress plays the essential role in drug abuse and relapse; nevertheless, little is known about the mechanisms underlying stress and relapse. Accordingly, the effects of intra-accumbal administration of Sulpiride, as a dopamine D2-like receptor antagonist, on an ineffective morphine dose+food deprivation(FD)- and morphine priming-induced reinstatement of conditioned place preference (CPP). 104 adult male albino Wistar rats weighing 200-280g were bilaterally implanted by cannula into the nucleus accumbens (NAc)...
November 30, 2016: Synapse
https://www.readbyqxmd.com/read/27902414/modulation-of-intestinal-barrier-function-to-ameliorate-salmonella-infection-in-mice-by-oral-administration-of-fermented-milks-produced-with-lactobacillus-plantarum-mtcc-5690-a-probiotic-strain-of-indian-gut-origin
#3
Namita Rokana, Rajbir Singh, Rashmi Hogarehalli Mallappa, Virender Kumar Batish, Sunita Grover
Probiotic Lactobacillus plantarum MTCC 5690 -a probiotic strain of Indian gut origin as such and milk formulations produced with the same were explored in this sudy as biotherapeutics by evauating their functional efficacy against Salmonella infection in mice. The efficacy of milk formulations (fermented/unfermented) of MTCC 5690 for enhancement of intestinal barrier function was determined by monitoring the permeability and histopathology of intestine. The mice fed with probiotic Dahi (PD), Fermented Probiotic Drink (FD) and Sweetened fermented probiotic drink (SFD) maintained the health and integrity of intestinal epithelium in the infected mice as compared to those fed with phosphate buffered saline, milk, unfermented probiotic milk and Dahi...
October 17, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27900791/robust-graft-survival-and-normalized-dopaminergic-innervation-does-not-obligate-recovery-in-a-pd-patient
#4
Jeffrey H Kordower, Christopher G Goetz, Yaping Chu, Glenda M Halliday, Daniel A Nicholson, Timothy Musial, David J Marmion, A Jon Stoessl, Vesna Sossi, Thomas B Freeman, C Warren Olanow
OBJECTIVE: The main goal of dopamine cell replacement therapy in Parkinson's disease (PD) is to provide clinical benefit mediated by graft survival with nigrostriatal reinnervation. We report a dichotomy between graft structure and clinical function in a patient dying sixteen years following fetal nigral grafting. METHODS: A 55-year-old levodopa-responsive woman with PD received bilateral putamenal fetal mesencephalic grafts as part of an NIH-sponsored double-blind sham-controlled trial...
November 30, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27898310/potential-human-exposure-to-halogenated-flame-retardants-in-elevated-surface-dust-and-floor-dust-in-an-academic-environment
#5
Jaime M Allgood, Tamara Jimah, Carolyn M McClaskey, Mark J La Guardia, Stephanie C Hammel, Maryam M Zeineddine, Ian W Tang, Miryha G Runnerstrom, Oladele A Ogunseitan
Most households and workplaces all over the world possess furnishings and electronics, all of which contain potentially toxic flame retardant chemicals to prevent fire hazards. Indoor dust is a recognized repository of these types of chemicals including polybrominated diphenyl ethers (PBDEs) and non-polybrominated diphenyl ethers (non-PBDEs). However, no previous U.S. studies have differentiated concentrations from elevated surface dust (ESD) and floor dust (FD) within and across microenvironments. We address this information gap by measuring twenty-two flame-retardant chemicals in dust on elevated surfaces (ESD; n=10) and floors (FD; n=10) from rooms on a California campus that contain various concentrations of electronic products...
November 26, 2016: Environmental Research
https://www.readbyqxmd.com/read/27897152/a-novel-multi-frequency-electrical-impedance-tomography-spectral-imaging-algorithm-for-early-stroke-detection
#6
Lin Yang, Canhua Xu, Meng Dai, Feng Fu, Xuetao Shi, Xiuzhen Dong
Multi-frequency electrical impedance tomography (MFEIT) reconstructs the image of conductivity inside the human body based on the dependence of tissue conductivity on frequency. As there exist differences in the conductivity over frequency between blood, ischemic cortical tissue and normal cortical tissue, MFEIT has potential application in the detection of acute stroke. However, because the conductivity distribution of the human head is highly inhomogeneous and the conductivities of normal head tissue and stroke lesion tissue both change with frequency, the anomaly and normal head tissues are often mixed together in the reconstructed image, which makes it difficult to discern the anomaly...
November 29, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27894842/energetic-basis-on-interactions-between-ferredoxin-and-ferredoxin-nadp-reductase-at-varying-physiological-conditions
#7
Misaki Kinoshita, Ju Yaen Kim, Satoshi Kume, Yuxi Lin, K Hun Mok, Yosky Kataoka, Koichiro Ishimori, Natalia Markova, Genji Kurisu, Toshiharu Hase, Young-Ho Lee
In spite of a number of studies to characterize ferredoxin (Fd):ferredoxin NADP(+) reductase (FNR) interactions at limited conditions, detailed energetic investigation on how these proteins interact under near physiological conditions and its linkage to FNR activity are still lacking. We herein performed systematic Fd:FNR binding thermodynamics using isothermal titration calorimetry (ITC) at distinct pH (6.0 and 8.0), NaCl concentrations (0-200 mM), and temperatures (19-28 °C) for mimicking physiological conditions in chloroplasts...
November 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27894323/health-related-quality-of-life-and-a-cost-utility-simulation-of-adults-in-the-uk-with-osteogenesis-imperfecta-x-linked-hypophosphatemia-and-fibrous-dysplasia
#8
Lydia Forestier-Zhang, Laura Watts, Alison Turner, Harriet Teare, Jane Kaye, Joe Barrett, Cyrus Cooper, Richard Eastell, Paul Wordsworth, Muhammad K Javaid, Rafael Pinedo-Villanueva
BACKGROUND: Health-related quality of life of adults with osteogenesis imperfecta (OI), fibrous dysplasia (FD) and X-linked hypophosphatemia (XLH) remains poorly described. The aim of this study was to describe the HRQoL of adults with osteogenesis imperfecta, fibrous dysplasia and X-linked hypophophataemia and perform a cost-utility simulation to calculate the maximum cost that a health care system would be willing to pay for a hypothetical treatment of a rare bone disease. RESULTS: Participants completed the EQ-5D-5 L questionnaire between September 2014 and March 2016...
November 28, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27893521/lower-tear-meniscus-measurements-using-a-new-anterior-segment-swept-source-optical-coherence-tomography-and-agreement-with-fourier-domain-optical-coherence-tomography
#9
Pedro Arriola-Villalobos, José Ignacio Fernández-Vigo, David Díaz-Valle, Jaime Almendral-Gómez, Cristina Fernández-Pérez, José M Benítez-Del-Castillo
PURPOSE: To assess intraobserver repeatability and interobserver and intersession reproducibility of lower tear meniscus height (LTMH) measurements obtained using a new anterior segment swept-source optical coherence tomography (SS-OCT) device. Agreement with Fourier-domain (FD) OCT (Spectralis) was also examined. METHODS: In an observational cross-sectional study, one eye of 29 healthy subjects was randomly imaged with both devices at our center. Two examiners then randomly measured the LTMH using the software's calipers...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27892749/high-non-relapse-mortality-and-low-relapse-incidence-in-gender-mismatched-allogeneic-hematopoietic-stem-cell-transplantation-from-a-parous-female-donor-with-a-male-child
#10
Akihito Shinohara, Yoshihiro Inamoto, Saiko Kurosawa, Nobuhiro Hiramoto, Ryosuke Ueda, Takashi Tanaka, Kohei Tada, Yujin Kobayashi, Noriyuki Morikawa, Keiji Okinaka, Sung-Won Kim, Kinuko Tajima, Takahiro Fukuda
To clarify the influence of exposure to a male fetus during a female donor's (FD) pregnancy in allogeneic hematopoietic stem cell transplantation (HSCT), we retrospectively examined 292 HSCT patients. The 5-year non-relapse mortality (NRM) was 33.5% among 31 male recipients who had HSCT from FD with a male child (MC), 23.0% among 40 male recipients who had HSCT from FD without MC and 19.6% among 221 other recipients. The 5-year relapse incidence (RI) was 22.6%, 42.0%, and 43.1% for the respective group. In multivariate analysis, male recipients who had HSCT from FD with MC had an increased risk of NRM (hazard ratio [HR] 1...
November 28, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27888410/genome-sequence-prevalence-and-quantification-of-the-first-iflavirus-identified-in-a-phytoplasma-insect-vector
#11
Simona Abbà, Luciana Galetto, Marta Vallino, Marika Rossi, Massimo Turina, Anne Sicard, Cristina Marzachì
The leafhopper Euscelidius variegatus is a natural vector of chrysanthemum yellows phytoplasma (CY) and an efficient vector of flavescence dorée phytoplasma (FD) under laboratory conditions. During a transcriptome sequencing (RNA-seq) project aimed at investigating the interactions between the insect and the two phytoplasmas, a 10,616-nucleotide-long contig with high sequence similarity to known picorna-like viruses was identified among the assembled insect transcripts. The discovery came totally unexpected, because insects from the laboratory colony did not show any evident symptom that could be related to the presence of a virus...
November 25, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27888084/are-locked-facets-a-contraindication-for-extreme-lateral-interbody-fusion
#12
Rodrigo Navarro-Ramirez, Gernot Lang, Yu Moriguchi, Eric Elowitz, Jose Alfredo Corredor, Mauricio J Avila, Alberto Gotfryd, Marjan Alimi, Lena Gandevia, Roger Härtl
BACKGROUND: Extreme lateral interbody fusion (ELIF) has gained popularity as a minimally invasive treatment allowing for indirect decompression of neural elements. However, evidence regarding the influence of facet degeneration (FD) and facet tropism (FT) towards indirect decompression is lacking. The aim of the study was to evaluate whether indirect decompression is impaired by FD and FT in patients undergoing ELIF. METHODS: 37 patients undergoing ELIF were included in a retrospective study...
November 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27886142/gender-differences-in-the-application-of-spanish-criteria-for-initiation-of-enzyme-replacement-therapy-for-fabry-disease-in-the-fabry-outcome-survey
#13
Miguel-Ángel Barba-Romero, Guillem Pintos-Morell
Both male/female patients with Fabry disease (FD) may receive enzyme replacement therapy (ERT). Previously published analyses of the Fabry Outcome Survey (FOS; Shire-sponsored) database suggested gender differences in timing of ERT initiation. We assessed alignment of criteria for ERT initiation in the Spanish adult population included in FOS with recommendations of a Spanish national consensus. This retrospective analysis examined baseline clinical data of 88 adults (49 females) enrolled in the FOS database up to August 2014...
November 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27885652/intercellular-translocation-of-molecules-via-plasmodesmata-in-the-multiseriate-filamentous-brown-alga-halopteris-congesta-sphacelariales-phaeophyceae
#14
Chikako Nagasato, Atsuko Tanaka, Toshiaki Ito, Christos Katsaros, Taizo Motomura
Despite the high number of studies on the fine structure of brown algal cells, only limited information is available on the intercelluar transportation of molecules via plasmodesmata in brown algae. In this study, plasmodesmatal permeability of Halopteris congesta was examined by observing the translocation of microinjected fluorescent tracers of different molecular sizes. The tip region of H. congesta consists of a cylindrical apical cell while the basal region is multiseriate. Fluorescein isothiocyanate (FITC)-dextran (FD; 3, 10, and 20 kDa) and recombinant green fluorescent protein (27 kDa) were injected into the apical cell and was observed to diffuse into the neighboring cells...
November 25, 2016: Journal of Phycology
https://www.readbyqxmd.com/read/27884145/estimation-of-the-cool-executive-function-using-frontal-electroencephalogram-signals-in-first-episode-schizophrenia-patients
#15
Yi Yu, Yun Zhao, Yajing Si, Qiongqiong Ren, Wu Ren, Changqin Jing, Hongxing Zhang
BACKGROUND: In schizophrenia, executive dysfunction is the most critical cognitive impairment, and is associated with abnormal neural activities, especially in the frontal lobes. Complexity estimation using electroencephalogram (EEG) recording based on nonlinear dynamics and task performance tests have been widely used to estimate executive dysfunction in schizophrenia. METHODS: The present study estimated the cool executive function based on fractal dimension (FD) values of EEG data recorded from first-episode schizophrenia patients and healthy controls during the performance of three cool executive function tasks, namely, the Trail Making Test-A (TMT-A), Trail Making Test-B (TMT-B), and Tower of Hanoi tasks...
November 25, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27875885/morphology-of-symmetric-abcd-tetrablock-quaterpolymers-studied-by-monte-carlo-simulation
#16
Jiro Suzuki, Atsushi Takano, Yushu Matsushita
Morphology of symmetric ABCD tetrablock quaterpolymers in melt was studied by the Monte Carlo (MC) simulation, where the volume fractions of the block chains, f, kept the relationships of fA=fD and fB=fC, and the volume fraction of the two mid-blocks φ was defined as φ=fB+fC. Previous self-consistent field theory for ABCD reported morphological change including several structures; however, the scope was limited within a two-dimensional system. To the contrary, in this paper, MC simulations were carried out in three dimensions with changing the φ value finely, which resulted in finding a tetracontinuous structure in the range of 0...
November 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27873130/phase-i-clinical-and-pharmacokinetic-study-of-pm01183-a-tetrahydroisoquinoline-lurbinectedin-in-combination-with-gemcitabine-in-patients-with-advanced-solid-tumors
#17
Luis Paz-Ares, Martin Forster, Valentina Boni, Sergio Szyldergemajn, Jesús Corral, Samantha Turnbull, Antonio Cubillo, Carlos Fernandez Teruel, Iker López Calderero, Mariano Siguero, Patrick Bohan, Emiliano Calvo
Background To determine the recommended dose (RD) of a combination of PM01183 and gemcitabine in patients with advanced solid tumors. Methods Forty-five patients received escalating doses of PM01183/gemcitabine on Days 1 and 8 every 3 weeks (d1,8 q3wk) following a standard 3 + 3 design. Results PM01183 3.5 mg flat dose (FD)/gemcitabine 1000 mg/m(2) was the highest dose level tested. Dose-limiting toxicities (DLTs) were mostly hematological and resulted in the expansion of a lower dose level (PM01183 3...
November 21, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27868158/growth-and-prevalence-of-feeding-difficulties-in-children-with-robin-sequence-a-retrospective-cohort-study
#18
Emma C Paes, Iris A C de Vries, Wouter M Penris, Karlijn H Hanny, Selma W Lavrijsen, Elselien K van Leerdam, Maaike M Rademaker, Esther S Veldhoen, Rene M J C Eijkemans, Moshe Kon, Corstiaan C Breugem
OBJECTIVES: In addition to breathing problems, patients with Robin sequence (RS) often encounter feeding difficulties (FD). Data regarding the occurrence of FD and possible influencing factors are scarce. The study aim was to elucidate these factors to improve treatment strategies. MATERIAL AND METHODS: A retrospective comparative cohort study was conducted, consisting of 69 infants diagnosed with both RS and a cleft palate and 64 isolated cleft palate only (iCPO) infants...
November 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27867690/good-adherence-to-mediterranean-diet-can-prevent-gastrointestinal-symptoms-a-survey-from-southern-italy
#19
Francesco Paolo Zito, Barbara Polese, Letizia Vozzella, Antonietta Gala, Daniela Genovese, Viviana Verlezza, Fabiana Medugno, Antonello Santini, Luigi Barrea, Martina Cargiolli, Paolo Andreozzi, Giovanni Sarnelli, Rosario Cuomo
AIM: To evaluate how different levels of adherence to a mediterranean diet (MD) correlate with the onset of functional gastrointestinal disorders. METHODS: As many as 1134 subjects (598 M and 536 F; age range 17-83 years) were prospectively investigated in relation to their dietary habits and the presence of functional gastrointestinal symptoms. Patients with relevant chronic organic disease were excluded from the study. The Mediterranean Diet Quality index for children and adolescents (KIDMED) and the Short Mediterranean Diet Questionnaire were administered...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27866769/modular-virus-like-particles-for-sublingual-vaccination-against-group-a-streptococcus
#20
Arjun Seth, Il Gyu Kong, Su-Hyun Lee, Jin-Young Yang, Yong-Soo Lee, Yeji Kim, Nani Wibowo, Anton P J Middelberg, Linda H L Lua, Mi-Na Kweon
Infection with Group A streptococcus (GAS)-an oropharyngeal pathogen-leads to mortality and morbidity, primarily among developing countries and indigenous populations in developed countries. The development of safe and affordable GAS vaccines is challenging, due to the presence of various unique GAS serotypes, antigenic variation within the same serotype, and potential auto-immune responses. In the present study, we evaluated the use of a sublingual freeze-dried (FD) formulation based on immunogenic modular virus-like particles (VLPs) carrying the J8 peptide (J8-VLPs) as a potential safe and cost-effective GAS vaccine for inducing protective systemic and mucosal immunity...
December 12, 2016: Vaccine
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