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https://www.readbyqxmd.com/read/29457572/early-effects-on-the-intestinal-barrier-and-pancreatic-function-after-enteral-stimulation-with-protease-or-kidney-bean-lectin-in-neonatal-rats
#1
Ester Arévalo Sureda, Olena Prykhodko, Björn Weström
Gut maturation naturally accelerates at weaning in altricial mammalian species, such as the rat. Mimicking this, gut development can also be induced precociously, 3-4 d earlier than it would occur naturally, by enteral exposure to phytohaemagglutinin (PHA), or various proteases. We investigated the early effects of gut provocation on intestinal barrier and pancreatic functions, to get a better understanding of the mechanisms that initiate gut maturation. The effects of oral administration of protease (trypsin) or PHA to 14-d-old suckling rats were studied during 24 h in comparison with water-fed controls...
February 19, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29457264/comparison-of-left-atrial-size-and-function-in-hypertrophic-cardiomyopathy-and-in-fabry-disease-with-left-ventricular-hypertrophy
#2
María Cristina Saccheri, Tomás Francisco Cianciulli, Wilde Challapa Licidio, Jorge A Lax, Martín A Beck, Luis A Morita, Juan A Gagliardi
BACKGROUND: Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) are two diseases with a different pathophysiology, both cause left ventricular hypertrophy (LVH) and myocardial fibrosis. Although remodeling and systolic dysfunction of the left atrium (LA) are associated with atrial fibrillation and stroke in HCM, changes in the size and function of the LA have not been well studied in FD with LVH. METHODS: The following groups were studied prospectively, and their respective findings compared: 19 patients with non-obstructive HCM (Group I), 20 patients with a diagnosis of Fabry cardiomyopathy (Group II), and 20 normal subjects matched for sex and age (Group III)...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29457012/impact-of-folliculitis-decalvans-on-quality-of-life-and-subjective-perception-of-disease
#3
Cristina Pindado-Ortega, David Saceda-Corralo, Laura Miguel-Gómez, Diego Buendía-Castaño, Pablo Fernández-González, Oscar M Moreno-Arrones, Pablo Fonda-Pascual, Adrian Alegre-Sánchez, Rita Rodrigues-Barata, Sergio Vañó-Galván
Folliculitis decalvans (FD) is a primary neutrophilic scarring alopecia characterized by perifollicular papules, crusts, and pustules frequently located on the vertex. FD may affect young men and women. Since it may lead to hair loss, it can have a negative impact on patients' quality of life. Nevertheless, studies have focused on clinical, prognostic, and therapeutic aspects without considering the psychological impact of FD. In our study, we found that FD patients experienced a considerable impact on their quality of life...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29456709/anterior-spinal-instrumentation-combining-a-prosthetic-disc-nucleus-with-a-flexible-stabilization-device-manufacture-and-use-in-intervertebral-disc-repair
#4
Da Bao, Dawei Li
Artificial disc replacement alone is unable to completely cure cervical degenerative diseases; thus, a stabilization device markedly improves patient recovery. In order to meet this requirement, an anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device (ASI combining PDN/FD) was developed. An artificial disc was designed and manufactured using polyvinyl alcohol hydrogel (PVA-H) with a repeated freeze-melting technique, and subsequently the dehydration and swelling properties of the PVA-H were investigated...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455040/a-simple-method-for-calculating-the-likelihood-ratio-in-a-kinship-test-using-x-chromosomal-markers-incorporating-linkage-linkage-disequilibrium-and-mutation
#5
Mamiko Fukuta, Mohammed Hassan Gaballah, Hideaki Kato, Yasuhiro Aoki
X-chromosomal short tandem repeats (X-STRs) are useful for personal identification and kinship tests. However, it has not yet been fully established how to incorporate linkage and linkage disequilibrium (LD) into the calculation of the likelihood ratio (LR). In this paper, we describe a simple calculation method of LR for X-STRs that incorporated linkage, LD, and mutations. Initially, Japanese population data of 27 X-STRs (DXS6807, DXS9902, DXS6795, DXS6810, DXS10076, DXS10077, DXS10078, DXS10162, DXS10163, DXS10164, DXS7132, DXS981, DXS6800, DXS6803, DXS6809, DXS6789, DXS6799, DXS7424, DXS101, DXS7133, GATA172D05, DXS10103, HPRTB, GATA31E08, DXS8377, DXS10147, and DXS7423) were collected from 748 unrelated individuals to estimate the influence of LD...
February 12, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29455026/an-approach-for-cell-viability-online-detection-based-on-the-characteristics-of-lensfree-cell-diffraction-fingerprint
#6
Guoxiao Li, Rongbiao Zhang, Ning Yang, Changsheng Yin, Mingji Wei, Yecheng Zhang, Jian Sun
To overcome the drawbacks such as low automation and high cost, an approach for cell viability online detection is proposed, based on the extracted lensfree cell diffraction fingerprint characteristics. The cell fingerprints are acquired by a constructed large field-of-view (FOV) diffraction imaging platform without any lenses. The approach realizes distinguishing live and dead cells online and calculating cell viability index based on the number of live cells. With theoretical analysis and simulation, diffraction fingerprints of cells with different morphology are simulated and two characteristics are discovered to be able to reflect cell viability status effectively...
February 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29455022/adaptive-pathway-development-for-fabry-disease-a-clinical-approach
#7
REVIEW
Yvonne Schuller, Maarten Arends, Simon Körver, Mirjam Langeveld, Carla E M Hollak
Fabry disease (FD) is a rare X-chromosome-linked lysosomal storage disorder. Although initial expectations of enzyme replacement therapy (ERT) were high, it is now clear that real-world effectiveness is disappointing and evidence gathering has been inadequate. In retrospect, development of ERT for FD had several shortcomings. Little convincing evidence on the effectiveness existed at time of authorization. Also, post-marketing evaluation failed to generate sufficient and relevant data for adequate evaluation on effectiveness...
February 15, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29452581/prospective-observational-study-on-assessing-the-hemodynamic-relevance-of-patent-ductus-arteriosus-with-frequency-domain-near-infrared-spectroscopy
#8
Christoph E Schwarz, Antonio Preusche, Martin Wolf, Christian F Poets, Axel R Franz
BACKGROUND: What constitutes a hemodynamically relevant patent ductus arteriosus (hrPDA) in preterm infants is unclear. Different clinical and echocardiographic parameters are used, but a gold standard definition is lacking. Our objective was to evaluate associations between regional cerebral tissue oxygen saturation (rcStO 2 ), fraction of tissue oxygen extraction (rcFtO 2 E) measured by frequency domain near-infrared spectroscopy (fd-NIRS) and their correlation to echocardiographic, Doppler-ultrasound, and clinical parameters in preterm infants with and without a hrPDA...
February 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29450541/induction-of-ocular-complement-activation-by-inflammatory-stimuli-and-intraocular-inhibition-of-complement-factor-d-in-animal-models
#9
Maura A Crowley, Omar Delgado, Adrian Will-Orrego, Natasha M Buchanan, Karen Anderson, Bruce D Jaffee, Thaddeus P Dryja, Sha-Mei Liao
Purpose: Genome-wide association studies suggest a role for the complement system in age-related macular degeneration (AMD). We characterized ocular complement activation and evaluated a complement factor D (FD) neutralizing antibody. Methods: Mice were treated with toll-like receptor (TLR) ligands, intravitreal injection (IVT), or corneal debridement. Levels of complement proteins and mRNA were measured. A FD neutralizing antibody was administered IVT into eyes of rabbits that were challenged with LPS (lipopolysaccharide) administered intravenously...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29447481/regularity-changes-of-the-retinal-nerve-fiber-layer-and-macular-ganglion-cell-complex-in-patients-with-the-amnestic-mild-cognitive-impairment
#10
Yue Wu, Xiao-Ni Wang, Ningli Wang, Ying Han, Daqing Ma, Yan Lu
Background We investigated the regularity changes of the retinalnerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic Mild Cognitive Impairment (aMCI) patients in this prospective cohort study. Methods Twenty-four aMCI patients and 30 health controls, who are more than 60 years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with fourier-domain optical coherence tomography (FD-OCT). Results Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients...
February 15, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29444068/multi-distance-diffuse-optical-spectroscopy-with-a-single-optode-via-hypotrochoidal-scanning
#11
Matthew B Applegate, Darren Roblyer
Frequency-domain diffuse optical spectroscopy (FD-DOS) is an established technique capable of determining optical properties and chromophore concentrations in biological tissue. Most FD-DOS systems use either manually positioned, handheld probes or complex arrays of source and detector fibers to acquire data from many tissue locations, allowing for the generation of 2D or 3D maps of tissue. Here, we present a new method to rapidly acquire a wide range of source-detector (SD) separations by mechanically scanning a single SD pair...
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29437868/agalsidase-alfa-versus-agalsidase-beta-for-the-treatment-of-fabry-disease-an-international-cohort-study
#12
Maarten Arends, Marieke Biegstraaten, Christoph Wanner, Sandra Sirrs, Atul Mehta, Perry M Elliott, Daniel Oder, Oliver T Watkinson, Daniel G Bichet, Aneal Khan, Mark Iwanochko, Frédéric M Vaz, André B P van Kuilenburg, Michael L West, Derralynn A Hughes, Carla E M Hollak
BACKGROUND: Two recombinant enzymes (agalsidase alfa 0.2 mg/kg/every other week and agalsidase beta 1.0 mg/kg/every other week) have been registered for the treatment of Fabry disease (FD), at equal high costs. An independent international initiative compared clinical and biochemical outcomes of the two enzymes. METHODS: In this multicentre retrospective cohort study, clinical event rate, left ventricular mass index (LVMI), estimated glomerular filtration rate (eGFR), antibody formation and globotriaosylsphingosine (lysoGb3) levels were compared between patients with FD treated with agalsidase alfa and beta at their registered dose after correction for phenotype and sex...
February 7, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29435868/ambulatory-blood-pressure-profiles-in-familial-dysautonomia
#13
Lior Goldberg, Bat-El Bar-Aluma, Alex Krauthammer, Ori Efrati, Yehonatan Sharabi
OBJECTIVE: Familial dysautonomia (FD) is a rare genetic disease that involves extreme blood pressure fluctuations secondary to afferent baroreflex failure. The diurnal blood pressure profile, including the average, variability, and day-night difference, may have implications for long-term end organ damage. The purpose of this study was to describe the circadian pattern of blood pressure in the FD population and relationships with renal and pulmonary function, use of medications, and overall disability...
February 12, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29435308/complementary-and-alternative-treatment-in-functional-dyspepsia
#14
REVIEW
Giuseppe Chiarioni, Marcella Pesce, Alberto Fantin, Giovanni Sarnelli
Introduction and aim: The popularity of complementary and alternative medicine (CAM) in treating functional gastrointestinal disorders (FGIDs) has steadily increased in Western countries. We aimed at analyzing available data on CAM effectiveness in functional dyspepsia (FD) patients. Methods: A bibliographical search was performed in PubMed using the following keywords: "complementary/alternative medicine," "hypnosis," "acupuncture" and/or "functional dyspepsia...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29434653/shuganyin-decoction-improves-the-intestinal-barrier-function-in-a-rat-model-of-irritable-bowel-syndrome-induced-by-water-avoidance-stress
#15
Lu Lu, Liang Yan, Jianye Yuan, Qing Ye, Jiang Lin
Background: To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress. Methods: Forty male Wistar rats were divided into control, water-avoidance stress (WAS) group, WAS plus Shuganyin decoction (SGD) group and WAS plus dicetel (Dicetel) group. IBS was induced in rats by subjecting them to water-avoidance stress for 7 days. On day 4 of the WAS protocol, the rats were treated for 7 consecutive days (days 4-11) with SGD, dicetel or a negative control (saline)...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29434178/a-case-series-of-fibro-osseous-lesions-of-the-jaws
#16
Masaya Akashi, Kenji Matsuo, Manabu Shigeoka, Yasumasa Kakei, Takumi Hasegawa, Akira Tachibana, Shungo Furudoi, Takahide Komori
The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions...
December 18, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29433279/characterization-of-aroma-active-compounds-in-chinese-quince-pseudocydonia-sinensis-schneid-by-aroma-dilution-analyses
#17
Ji Young Choi, Sang Mi Lee, Hyong Joo Lee, Young-Suk Kim
Aroma-active compounds in the peel and pulp of Chinese quince fruits were extracted by high-vacuum distillation (HVD) and headspace solid-phase microextraction (HS-SPME) methods and identified by gas chromatography-olfactometry (GC-O) combined with aroma dilution analyses. Ethyl 2-methylpropanoate, ethyl (E)-2-butenoate, ethyl 2-methylbutanoate, methional, (Z)-3-hexenyl acetate, β-ionone, ethyl nonanoate, and γ-decalactone were detected as the potent aroma-active compounds (log3FD factors≥5) in the peel of Chinese quince, while hexanal, (Z)-3-hexenal, and (Z)-3-hexenol, which have a green odor note, were potent aroma-active compounds with high log3FD factors (≥3) in the pulp of Chinese quince...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432834/polymer-blends-used-to-develop-felodipine-loaded-hollow-microspheres-for-improved-oral-bioavailability
#18
Chao Pi, Ting Feng, Jing Liang, Hao Liu, Dongmei Huang, Chenglin Zhan, Jiyuan Yuan, Robert J Lee, Ling Zhao, Yumeng Wei
Felodipine (FD) has been widely used in anti-hypertensive treatment. However, it has extremely low aqueous solubility and poor bioavailability. To address these problems, FD hollow microspheres as multiple-unit dosage forms were synthesized by a solvent diffusion evaporation method. Particle size of the hollow microspheres, types of ethylcellulose (EC), amounts of EC, polyvinyl pyrrolidone (PVP) and FD were investigated based on an orthogonal experiment of three factors and three levels. In addition, the release kinetics in vitro and pharmacokinetics in beagle dogs of the optimized FD hollow microspheres was investigated and compared with Plendil (commercial FD sustained-release tablets) as a single-unit dosage form...
February 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29432486/fractal-analysis-of-plaque-border-a-novel-method-for-the-quantification-of-atherosclerotic-plaque-contour-irregularity-is-associated-with-pro-atherogenic-plasma-lipid-profile-in-subjects-with-non-obstructive-carotid-stenoses
#19
Francesco Moroni, Marco Magnoni, Vittoria Vergani, Enrico Ammirati, Paolo G Camici
BACKGROUND AND AIMS: Plaque border irregularity is a known imaging characteristic of vulnerable plaques, but its evaluation heavily relies on subjective evaluation and operator expertise. Aim of the present work is to propose a novel fractal-analysis based method for the quantification of atherosclerotic plaque border irregularity and assess its relation with cardiovascular risk factors. METHODS AND RESULTS: Forty-two asymptomatic subjects with carotid stenosis underwent ultrasound evaluation and assessment of cardiovascular risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29429810/envelope-proteins-of-two-hiv-1-clades-induced-different-epitope-specific-antibody-response
#20
Tripti Shrivastava, Sweety Samal, Ashish K Tyagi, Sandeep Goswami, Naresh Kumar, Gabriel Ozorowski, Andrew B Ward, Bimal K Chakrabarti
Using HIV-1 envelope protein (Env)-based immunogens that closely mimic the conformation of functional HIV-1 Envs and represent the isolates prevalent in relevant geographical region is considered a rational approach towards developing HIV vaccine. We recently reported that like clade B Env, JRFL, membrane bound Indian clade C Env, 4-2.J41 is also efficiently cleaved and displays desirable antigenic properties for plasmid DNA immunization. Here, we evaluated the immune response in rabbit by injecting the animals with plasmid expressing membrane bound efficiently cleaved 4-2...
February 8, 2018: Vaccine
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