Aline Cristina Parletta, Gabriela Cavazza Cerri, Claudia Ribeiro Borba Gasparini, Karine Panico, Denival Nascimento Vieira-Junior, Larissa Maria Zacarias-Rodrigues, Nathalia Senger, Amanda de Almeida Silva, Marina Fevereiro, Gabriela Placoná Diniz, Maria Cláudia Costa Irigoyen, Maria Luiza Morais Barreto-Chaves
Cardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation...
April 29, 2024: Pflügers Archiv: European Journal of Physiology