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independent component analysis

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https://www.readbyqxmd.com/read/28453543/altered-resting-state-intra-and-inter-network-functional-connectivity-in-patients-with-persistent-somatoform-pain-disorder
#1
Zhiyong Zhao, Tianming Huang, Chaozheng Tang, Kaiji Ni, Xiandi Pan, Chao Yan, Xiaoduo Fan, Dongrong Xu, Yanli Luo
Patients with persistent somatoform pain disorder (PSPD) usually experience various functional impairments in pain, emotion, and cognition, which cannot be fully explained by a physiological process or a physical disorder. However, it is still not clear for the mechanism underlying the pathogenesis of PSPD. The present study aimed to explore the intra- and inter-network functional connectivity (FC) differences between PSPD patients and healthy controls (HCs). Functional magnetic resonance imaging (fMRI) was performed in 13 PSPD patients and 23 age- and gender-matched HCs...
2017: PloS One
https://www.readbyqxmd.com/read/28448997/altered-expression-of-hippo-signaling-pathway-molecules-in-intrahepatic-cholangiocarcinoma
#2
Keishi Sugimachi, Miki Nishio, Shinichi Aishima, Yosuke Kuroda, Tomohiro Iguchi, Hisateru Komatsu, Hidenari Hirata, Shotaro Sakimura, Hidetoshi Eguchi, Yuki Bekki, Kenji Takenaka, Yoshihiko Maehara, Akira Suzuki, Koshi Mimori
OBJECTIVE: MOB1, a core component of the Hippo signaling pathway, suppresses cell proliferation, and MOB1 liver conditional knockout mice develop intrahepatic cholangiocarcinoma (ICC). However, its clinical significance in human ICC has not been established. The aim of this study was to characterize protein levels and the role of Hippo and TGF pathways in ICCs. METHODS: The protein levels of yes-associated protein 1 (YAP1), MOB1, Smad2, and TGFβ2 in 88 ICC cases were analyzed...
April 28, 2017: Oncology
https://www.readbyqxmd.com/read/28448601/determinants-of-coronary-flow-reserve-in-non-diabetic-patients-with-chest-pain-without-myocardial-perfusion-defects
#3
Helena U Westergren, Erik Michaëlsson, Juuso I Blomster, Tasso Miliotis, Sara Svedlund, Li-Ming Gan
BACKGROUND: Microvascular dysfunction could be responsible for chest pain in patients without myocardial perfusion defects. We evaluated microvascular function using ultrasound-assessed coronary flow reserve (CFR) in patients with chest pain and normal myocardial perfusion scintigram. Secondly, we investigated association between cardiovascular parameters and decreased CFR in a sex specific manner. METHODS: A total of 202 (128 women) non-diabetic patients with chest pain and suspected myocardial ischemia, but without myocardial perfusion defects on myocardial perfusion scintigram, were enrolled and underwent CFR examination and blood sampling...
2017: PloS One
https://www.readbyqxmd.com/read/28447844/frontal-theta-band-oscillations-predict-error-correction-and-posterror-slowing-in-typing
#4
Çığır Kalfaoğlu, Tom Stafford, Elizabeth Milne
Performance errors are associated with robust behavioral and electroencephalography (EEG) effects. However, there is a debate about the nature of the relationship between these effects and implicit versus explicit error awareness. Our aim was to study the relationship between error related electrophysiological effects, such as spectral perturbations in fronto-medial theta band oscillations (FMT), and error awareness in typing. Typing has an advantage as an experimental paradigm in that detected errors are quickly and habitually signaled by the participant using backspace, allowing separation of detected from undetected errors without interruption in behavior...
April 27, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28447220/track-weighted-dynamic-functional-connectivity-tw-dfc-a-new-method-to-study-time-resolved-functional-connectivity
#5
Fernando Calamante, Robert E Smith, Xiaoyun Liang, Andrew Zalesky, Alan Connelly
Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a means to combine structural/functional connectivity information into a single image. We extend here TW-FC in two important ways: first, all the functional data are used without having to define a prior functional network (cf...
April 26, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28447169/modeling-of-carbon-dioxide-mass-transfer-behavior-in-attached-cultivation-photobioreactor-using-the-analysis-of-the-ph-profiles
#6
Chunli Ji, Junfeng Wang, Runzhi Li, Tianzhong Liu
The CO2 mass transfer model associated with growth kinetics of microalgal biofilm in attached cultivation photobioreactor was developed and verified by using the analysis of pH profiles which were in equilibrium with inorganic carbon components concentrations (CO2, H2CO3, HCO3(-) and CO3(2-)) in medium. Model simulation results showed that the model well presented the biofilm growth process. The overall volumetric mass transfer coefficient of CO2 was more influenced by CO2 concentration in aerated gas but less by gas aeration rate and medium circulation rate...
April 26, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28445818/weighted-partial-least-squares-based-on-the-error-and-variance-of-the-recovery-rate-in-calibration-set
#7
Shaohui Yu, Xue Xiao, Hong Ding, Ge Xu, Haixia Li, Jing Liu
The quantitative analysis is very difficult for the emission-excitation fluorescence spectroscopy of multi-component mixtures whose fluorescence peaks are serious overlapping. As an effective method for the quantitative analysis, partial least squares can extract the latent variables from both the independent variables and the dependent variables, so it can model for multiple correlations between variables. However, there are some factors that usually affect the prediction results of partial least squares, such as the noise, the distribution and amount of the samples in calibration set etc...
April 19, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28445789/characterisation-of-pb-induced-changes-and-prediction-of-pb-exposure-in-microalgae-using-infrared-spectroscopy
#8
Ly Dao, John Beardall, Philip Heraud
Macromolecular changes in Chlorella sp. FleB1 and Scenedesmus acutus YaA6 exposed to Pb were characterised by Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy. Spectra were collected in the mid-infrared spectral region and a chemometric approach was used to analyse the spectra. Principal Component Analysis showed that under Pb treatment, carbohydrates and lipids increased while proteins and phosphorylated molecules decreased in both the isolates. These conclusions were corroborated by conventional measurements of photosynthesis and neutral lipids...
April 14, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28443007/neuroimaging-of-human-balance-control-a-systematic-review
#9
REVIEW
Ellen Wittenberg, Jessica Thompson, Chang S Nam, Jason R Franz
This review examined 83 articles using neuroimaging modalities to investigate the neural correlates underlying static and dynamic human balance control, with aims to support future mobile neuroimaging research in the balance control domain. Furthermore, this review analyzed the mobility of the neuroimaging hardware and research paradigms as well as the analytical methodology to identify and remove movement artifact in the acquired brain signal. We found that the majority of static balance control tasks utilized mechanical perturbations to invoke feet-in-place responses (27 out of 38 studies), while cognitive dual-task conditions were commonly used to challenge balance in dynamic balance control tasks (20 out of 32 studies)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28442624/unphosphorylated-isgf3-drives-constitutive-expression-of-interferon-stimulated-genes-to-protect-against-viral-infections
#10
Wenshi Wang, Yuebang Yin, Lei Xu, Junhong Su, Fen Huang, Yijin Wang, Patrick P C Boor, Kan Chen, Wenhui Wang, Wanlu Cao, Xinying Zhou, Pengyu Liu, Luc J W van der Laan, Jaap Kwekkeboom, Maikel P Peppelenbosch, Qiuwei Pan
Interferon (IFN)-stimulated genes (ISGs) are antiviral effectors that are induced by IFNs through the formation of a tripartite transcription factor ISGF3, which is composed of IRF9 and phosphorylated forms of STAT1 and STAT2. However, we found that IFN-independent ISG expression was detectable in immortalized cell lines, primary intestinal and liver organoids, and liver tissues. The constitutive expression of ISGs was mediated by the unphosphorylated ISGF3 (U-ISGF3) complex, consisting of IRF9 together with unphosphorylated STAT1 and STAT2...
April 25, 2017: Science Signaling
https://www.readbyqxmd.com/read/28442422/effects-of-low-frequency-rtms-treatment-on-brain-networks-for-inner-speech-in-patients-with-schizophrenia-and-auditory-verbal-hallucinations
#11
Leonie Bais, Edith Liemburg, Ans Vercammen, Richard Bruggeman, Rikus Knegtering, André Aleman
INTRODUCTION: Efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) targeting the temporo-parietal junction (TPJ) for the treatment of auditory verbal hallucinations (AVH) remains under debate. We assessed the influence of a 1Hz rTMS treatment on neural networks involved in a cognitive mechanism proposed to subserve AVH. METHODS: Patients with schizophrenia (N=24) experiencing medication-resistant AVH completed a 10-day 1Hz rTMS treatment. Participants were randomized to active stimulation of the left or bilateral TPJ, or sham stimulation...
April 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28439637/tibiofemoral-rotational-alignment-affects-flexion-angles-in-navigated-posterior-stabilized-total-knee-arthroplasty
#12
Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Akihiko Toda, Shinya Oka, Kazuki Kodato, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda
PURPOSE: To investigate the tibiofemoral rotational profiles during navigated posterior-stabilized (PS) total knee arthroplasty (TKA) and investigate the effect on post-operative maximum flexion angles. METHODS: Twenty-five subjects, treated with navigated PS TKA, were enrolled, and the effect of posterior cruciate ligament (PCL) resection and component implantation on tibiofemoral rotational kinematics was statistically evaluated. Then, the effect of rotational alignment changes on the post-operative maximum angles was retrospectively examined in 96 subjects using the multiple regression analysis...
April 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28439189/development-and-evaluation-of-two-abbreviated-questionnaires-for-mentoring-and-research-self-efficacy
#13
Donna B Jeffe, Treva K Rice, Josephine E A Boyington, Dabeeru C Rao, Girardin Jean-Louis, Victor G Dávila-Román, Anne L Taylor, Betty S Pace, Mohamed Boutjdir
OBJECTIVES: To reduce respondent burden for future evaluations of the National Heart, Lung, and Blood Institute-supported Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE), a mentored-research education program, we sought to shorten the 33-item Ragins and McFarlin Mentor Role Instrument (RMMRI), measuring mentor-role appraisals, and the 69-item Clinical Research Appraisal Inventory (CRAI), measuring research self-efficacy. METHODS: Three nationally recruited, junior-faculty cohorts attended two, annual 2-3 week Summer Institutes (SI-1/SI-2: 2011/2012, 2012/2013, 2013/2014) at one of six PRIDE sites...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28438369/independent-prognostic-importance-of-respiratory-instability-and-sympathetic-nerve-activity-in-patients-with-chronic-heart-failure
#14
Hidetsugu Asanoi, Daisuke Harada, Yoshitaka Oda, Hiroshi Ueno, Junya Takagawa, Hisanari Ishise, Yukiko Goso, Shuji Joho, Hiroshi Inoue
BACKGROUND: Respiratory instability in chronic heart failure (CHF) is characterized by irregularly rapid respiration or non-periodic breathing rather than by Cheyne-Stokes respiration. We developed a new quantitative measure of respiratory instability (RSI) and examined its independent prognostic impact upon CHF. METHODS: In 87 patients with stable CHF, respiratory flow and muscle sympathetic nerve activity (MSNA) were simultaneously recorded. RSI was calculated from the frequency distribution of respiratory spectral components and very low frequency components...
April 21, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28434746/supplementing-an-immunomodulatory-feed-ingredient-to-modulate-thermoregulation-physiologic-and-production-responses-in-lactating-dairy-cows-under-heat-stress-conditions
#15
T Leiva, R F Cooke, A P Brandão, K M Schubach, L F D Batista, M F Miranda, E A Colombo, R O Rodrigues, J R G Junior, R L A Cerri, J L M Vasconcelos
This study compared vaginal temperature, physiologic, and productive parameters in lactating dairy cows supplemented or not with Omnigen-AF (Phibro Animal Health, Teaneck, NJ) during the summer months in a tropical environment. Thirty-two lactating, primiparous (n = 16) and multiparous (n = 16) pregnant Holstein × Gir cows were ranked by parity, days in milk, body weight, and body condition score (BCS), and assigned to receive (SUPP; n = 16) or not (CON; n = 16) Omnigen-AF (Phibro Animal Health, Teaneck, NJ) at 56 g/cow daily (as-fed basis)...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28434159/decreased-hemispheric-connectivity-and-decreased-intra-and-inter-hemisphere-asymmetry-of-resting-state-functional-network-connectivity-in-schizophrenia
#16
O Agcaoglu, R Miller, E Damaraju, B Rashid, J Bustillo, M S Cetin, T G M Van Erp, S McEwen, A Preda, J M Ford, K O Lim, D S Manoach, D H Mathalon, S G Potkin, V D Calhoun
Many studies have shown that schizophrenia patients have aberrant functional network connectivity (FNC) among brain regions, suggesting schizophrenia manifests with significantly diminished (in majority of the cases) connectivity. Schizophrenia is also associated with a lack of hemispheric lateralization. Hoptman et al. (2012) reported lower inter-hemispheric connectivity in schizophrenia patients compared to controls using voxel-mirrored homotopic connectivity. In this study, we merge these two points of views together using a group independent component analysis (gICA)-based approach to generate hemisphere-specific timecourses and calculate intra-hemisphere and inter-hemisphere FNC on a resting state fMRI dataset consisting of age- and gender-balanced 151 schizophrenia patients and 163 healthy controls...
April 22, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28433026/variational-koopman-models-slow-collective-variables-and-molecular-kinetics-from-short-off-equilibrium-simulations
#17
Hao Wu, Feliks Nüske, Fabian Paul, Stefan Klus, Péter Koltai, Frank Noé
Markov state models (MSMs) and master equation models are popular approaches to approximate molecular kinetics, equilibria, metastable states, and reaction coordinates in terms of a state space discretization usually obtained by clustering. Recently, a powerful generalization of MSMs has been introduced, the variational approach conformation dynamics/molecular kinetics (VAC) and its special case the time-lagged independent component analysis (TICA), which allow us to approximate slow collective variables and molecular kinetics by linear combinations of smooth basis functions or order parameters...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28432780/single-subject-independent-component-analysis-based-intensity-normalization-in-non-quantitative-multi-modal-structural-mri
#18
Sebastian Papazoglou, Jens Würfel, Friedemann Paul, Alexander U Brandt, Michael Scheel
Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on age and sex matched healthy controls. The proposed method leads to consistent and independent components with a significantly reduced coefficient-of-variation across subjects, suggesting potential to serve as automatic intensity normalization and thus to enhance the power of intensity based statistical analyses...
April 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28431691/sensorimotor-activity-measured-via-oscillations-of-eeg-mu-rhythms-in-speech-and-non-speech-discrimination-tasks-with-and-without-segmentation-demands
#19
David Thornton, Ashley W Harkrider, David Jenson, Tim Saltuklaroglu
Better understanding of the role of sensorimotor processing in speech and non-speech segmentation can be achieved with more temporally precise measures. Twenty adults made same/different discriminations of speech and non-speech stimuli pairs, with and without segmentation demands. Independent component analysis of 64-channel EEG data revealed clear sensorimotor mu components, with characteristic alpha and beta peaks, localized to premotor regions in 70% of participants.Time-frequency analyses of mu components from accurate trials showed that (1) segmentation tasks elicited greater event-related synchronization immediately following offset of the first stimulus, suggestive of inhibitory activity; (2) strong late event-related desynchronization in all conditions, suggesting that working memory/covert replay contributed substantially to sensorimotor activity in all conditions; (3) stronger beta desynchronization in speech versus non-speech stimuli during stimulus presentation, suggesting stronger auditory-motor transforms for speech versus non-speech stimuli...
April 18, 2017: Brain and Language
https://www.readbyqxmd.com/read/28428874/population-assessment-using-multivariate-time-series-analysis-a-case-study-of-rockfishes-in-puget-sound
#20
Nick Tolimieri, Elizabeth E Holmes, Gregory D Williams, Robert Pacunski, Dayv Lowry
Estimating a population's growth rate and year-to-year variance is a key component of population viability analysis (PVA). However, standard PVA methods require time series of counts obtained using consistent survey methods over many years. In addition, it can be difficult to separate observation and process variance, which is critical for PVA. Time-series analysis performed with multivariate autoregressive state-space (MARSS) models is a flexible statistical framework that allows one to address many of these limitations...
April 2017: Ecology and Evolution
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