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https://www.readbyqxmd.com/read/29767409/the-use-of-serum-free-light-chain-dimerization-patterns-assist-in-the-diagnosis-of-al-amyloidosis
#1
Moshe E Gatt, Batia Kaplan, Dean Yogev, Elana Slyusarevsky, Galina Pogrebijski, Sizilia Golderman, Olga Kukuy, Avi Livneh
The discrimination between benign and malignant forms of plasma cell dyscrasia (PCD) is often difficult. Free light chain monomer-dimer pattern analysis (FLC-MDPA) may assist in solving this dilemma and distinguish between AL amyloidosis and benign PCD. Serum samples of patients with AL amyloidosis and benign PCD were analysed in a blinded manner. Quantitative Western blotting was performed to estimate dimerization and clonality indices, and thereby determine the source of the tested samples, as derived either from benign or malignant PCD...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29765992/serological-immunoglobulin-free-light-chain-profile-in-myasthenia-gravis-patients
#2
Umberto Basile, Mariapaola Marino, Cecilia Napodano, Krizia Pocino, Paolo Emilio Alboini, Francesca Gulli, Amelia Evoli, Carlo Provenzano, Emanuela Bartoccioni
Background: Serological levels of free immunoglobulin light chains (FLCs), produced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab (RTX) therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus. Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction with antibodies (abs) targeting the acetylcholine receptor (AChR) or the muscle-specific tyrosine kinase (MuSK), inducing muscle weakness and excessive fatigability...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29764984/parallel-evolution-of-common-allelic-variants-confers-flowering-diversity-in-capsella-rubella
#3
Li Yang, Hui-Na Wang, Xing-Hui Hou, Yu-Pan Zou, Ting-Shen Han, Xiao-Min Niu, Jie Zhang, Zhong Zhao, Marco Todesco, Sureshkumar Balasubramanian, Ya-Long Guo
Flowering time is an adaptive life history trait. Capsella rubella, a close relative of Arabidopsis thaliana and a young species, displays extensive variation for flowering time but low standing genetic variation due to an extreme bottleneck event, providing an excellent opportunity to understand how phenotypic diversity can occur with a limited initial gene pool. Here, we demonstrate that common allelic variation and parallel evolution at the FLC locus confer variation in flowering time in C. rubella. We show that two overlapping deletions in the 5' UTR region of C...
May 15, 2018: Plant Cell
https://www.readbyqxmd.com/read/29761290/isolation-and-functional-characterization-of-a-floral-repressor-bcflc2-from-pak-choi-brassica-rapa-ssp-chinensis
#4
Feiyi Huang, Tongkun Liu, Jin Wang, Xilin Hou
BcFLC2 functioned as a repressor of flowering by directly regulating BcTEM1, BcMAF2, BcSOC1 and BcSPL15 in Pak-choi. FLOWERING LOCUS C (FLC) plays an important role in regulating flowering time. Here, we functionally described an FLC homologous gene, BcFLC2, that negatively regulated flowering in Pak-choi (Brassica rapa ssp. chinensis). The sequence comparison to Arabidopsis FLC showed that BcFLC2 also had a MADS-box domain at the N terminus. BcFLC2 was highly expressed in the leaves, roots, stems and stamens, and its expression was repressed by vernalization in Pak-choi...
May 14, 2018: Planta
https://www.readbyqxmd.com/read/29758717/biaxial-potential-of-surface-stabilized-ferroelectric-liquid-crystals
#5
Anatoly Kaznacheev, Evgeny Pozhidaev, Vladimir Rudyak, Alexander V Emelyanenko, Alexei Khokhlov
A biaxial surface potential Φ_{s} of smectic-C^{*} surface-stabilized ferroelectric liquid crystals (SSFLCs) is introduced in this paper to explain the experimentally observed electric-field dependence of polarization P[over ̃]_{cell}(E), in particular the shape of the static hysteresis loops. Our potential consists of three independent parts. The first nonpolar part Φ_{n} describes the deviation of the prime director n (which is the most probable orientation of the long molecular axes) from the easy alignment axis R, which is located in the boundary surface plane...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29755488/-medicago-truncatula-soc1-genes-are-up-regulated-by-environmental-cues-that-promote-flowering
#6
Jared B Fudge, Robyn H Lee, Rebecca E Laurie, Kirankumar S Mysore, Jiangqi Wen, James L Weller, Richard C Macknight
Like Arabidopsis thaliana , the flowering of the legume Medicago truncatula is promoted by long day (LD) photoperiod and vernalization. However, there are differences in the molecular mechanisms involved, with orthologs of two key Arabidopsis thaliana regulators, FLOWERING LOCUS C ( FLC ) and CONSTANS ( CO ), being absent or not having a role in flowering time function in Medicago . In Arabidopsis , the MADS-box transcription factor gene, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 ( AtSOC1 ), plays a key role in integrating the photoperiodic and vernalization pathways...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29747400/in-vitro-anticandidal-activity-and-mechanism-of-a-polyoxovanadate-functionalized-by-zn-fluconazole-complexes
#7
Shuanli Guo, Wei Yang, Mingming Zhao, Rui Tian, Boyu Zhang, Yanfei Qi
The rise in the number of fungal infections is requiring the rapid development of novel antifungal agents. A new polyoxovanadate functionalized by Zn-fluconazole coordination complexes, Zn₃(FLC)₆V10 O28 ·10H₂O (ZnFLC) (FLC = fluconazole) has been synthesized and evaluated for in vitro antifungal against Candida species. The identity of ZnFLC were confirmed by elemental analysis, IR spectrum, and single-crystal X-ray diffraction. The antifungal activities of ZnFLC was screened in 19 Candida species strains using the microdilution checkerboard technique...
May 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29743290/cerebrospinal-fluid-immunoglobulin-light-chain-ratios-predict-disease-progression-in-multiple-sclerosis
#8
Emma Rathbone, Lindsay Durant, James Kinsella, Antony R Parker, Ghaniah Hassan-Smith, Michael R Douglas, S John Curnow
OBJECTIVE: To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts. METHODS: CSF and peripheral blood were obtained from patients undergoing elective diagnostic lumbar puncture and included clinically isolated syndrome (CIS) (n=43), relapsing remitting MS (RRMS; n=50), primary progressive MS (PPMS; n=20) and other neurological disease controls, both inflammatory (ONID; n=23) and non-inflammatory (OND; n=114)...
May 9, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29742142/association-between-urinary-free-light-chains-and-progression-to-end-stage-renal-disease-in-chronic-kidney-disease
#9
Anthony Fenton, Mark D Jesky, Rachel Webster, Stephanie J Stringer, Punit Yadav, Iain Chapple, Indranil Dasgupta, Stephen J Harding, Charles J Ferro, Paul Cockwell
BACKGROUND: Patients with chronic kidney disease (CKD) are at an increased risk of developing end-stage renal disease (ESRD). We assessed for the first time whether urinary free light chains (FLC) are independently associated with risk of ESRD in patients with CKD, and whether they offer incremental value in risk stratification. MATERIALS AND METHODS: We measured urinary FLCs in 556 patients with CKD from a prospective cohort study. The association between urinary kappa/creatinine (KCR) and lambda/creatinine (LCR) ratios and development of ESRD was assessed by competing-risks regression (to account for the competing risk of death)...
2018: PloS One
https://www.readbyqxmd.com/read/29739080/serum-free-light-chain-predict-overall-survival-and-response-to-therapy-in-patients-with-newly-diagnosed-multiple-myeloma
#10
Yanis Meddour, Momahed C Rahali, Salah E Belakehal, Fatma Z Ardjoun, Samia Chaib, Reda Djidjik
BACKGROUND: Multiple myeloma is characterized by underlying clinical and biological heterogeneity, which translates to variable responses to treatment and outcome. METHODS: To assess the roles of serum free light chain (sFLC) and K/L FLC ratio (rFLC) in the diagnoses and prognoses of multiple myeloma (MM), sFLC levels and K/L ratios were measured in 112 patients with newly diagnosed multiple myeloma using the Freelite automated immunoassay. RESULTS: Abnormal sFLC and/or rFLC levels were detected 99...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736762/developmental-transcriptome-analysis-of-floral-transition-in-rosa-odorata-var-gigantea
#11
Xuelian Guo, Chao Yu, Le Luo, Huihua Wan, Ni Zhen, Yushu Li, Tangren Cheng, Jia Wang, Huitang Pan, Qixiang Zhang
Expression analyses revealed that floral transition of Rosa odorata var. gigantea is mainly regulated by VRN1, COLs, DELLA and KSN, with contributions by the effects of phytohormone and starch metabolism. Seasonal plants utilize changing environmental and developmental cues to control the transition from vegetative growth to flowering at the correct time of year. This study investigated global gene expression profiles at different developmental stages of Rosa odorata var. gigantea by RNA-sequencing, combined with phenotypic characterization and physiological changes...
May 7, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29736250/mikc-c-type-mads-box-genes-in-rosa-chinensis-the-remarkable-expansion-of-abcde-model-genes-and-their-roles-in-floral-organogenesis
#12
Jinyi Liu, Xiaodong Fu, Yuwei Dong, Jun Lu, Min Ren, Ningning Zhou, Changquan Wang
MIKCC -type MADS-box (MIKCC ) genes encode transcription factors that have crucial roles in controlling floral organogenesis and flowering time in plants. Although this gene family has been well characterized in many plant species, its evolutionary and comprehensive functional analysis in rose is lacking. In this study, 58 non-redundant MIKCC uni-transcripts were extensively identified from rose transcriptomes. Phylogenetic analysis placed these genes into 12 clades with their Arabidopsis and strawberry counterparts, and revealed that ABCDE model (including AP1/FUL, AP3/PI, AG, and SEP clades), and SOC1 and AGL6 clade genes have remarkably expanded in Rosa chinensis , whereas genes from the FLC and AGL17 clades were undetectable...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29733847/structural-insight-into-the-role-of-val1-b3-domain-for-targeting-to-flc-locus-in-arabidopsis-thaliana
#13
Baixing Wu, Mengmeng Zhang, Shichen Su, Hehua Liu, Jianhua Gan, Jinbiao Ma
Vernalization is a pivotal stage for some plants involving many epigenetic changes during cold exposure. In Arabidopsis, an essential step in vernalization for further flowering is successful silence the potent floral repressor Flowering Locus C (FLC) by repressing histone mark. AtVal1 is a multi-function protein containing five domains that participate into many recognition processes and is validated to recruit the repress histone modifier PHD-PRC2 complex and interact with components of the ASAP complex target to the FLC nucleation region through recognizing a cis element known as CME (cold memory element) by its plant-specific B3 domain...
May 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29730074/defining-the-characteristics-of-certified-hernia-centers-in-italy-the-italian-society-of-hernia-and-abdominal-wall-surgery-workgroup-consensus-on-systematic-reviews-of-the-best-available-evidences
#14
REVIEW
Cesare Stabilini, Giuseppe Cavallaro, Paolo Bocchi, Giampiero Campanelli, Michele Carlucci, Francesca Ceci, Feliciano Crovella, Diego Cuccurullo, Landino Fei, Ezio Gianetta, Francesco Gossetti, Dalila Patrizia Greco, Olga Iorio, Pierluigi Ipponi, Antonio Marioni, Giovanni Merola, Paolo Negro, Denise Palombo, Umberto Bracale
BACKGROUND: The terms "Hernia Center" (HC) and Hernia Surgeon" (HS) have gained more and more popularity in recent years. Nevertheless, there is lack of protocols and methods for certification of their activities and results. The Italian Society of Hernia and Abdominal Wall Surgery proposes a method for different levels of certification. METHODS: The national board created a commission, with the task to define principles and structure of an accreditation program...
May 3, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29725932/light-chain-cast-nephropathy-practical-considerations-in-the-management-of-myeloma-kidney-what-we-know-and-what-the-future-may-hold
#15
REVIEW
Sandhya Manohar, Samih H Nasr, Nelson Leung
PURPOSE OF REVIEW: To update and evaluate the current knowledge on pathogenesis and management of light chain cast nephropathy. Light chain cast nephropathy (LCCN) is the leading cause of acute renal failure in patients with multiple myeloma and is currently recognized as a myeloma defining event. RECENT FINDINGS: The immunoglobulin free light chain plays an integral role in the pathogenesis of LCCN. The level of free light chain (FLC) in the blood and urine is directly associated with the risk of developing LCCN...
May 3, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29709075/reduction-of-the-geomagnetic-field-delays-arabidopsis-thaliana-flowering-time-through-downregulation-of-flowering-related-genes
#16
Chiara Agliassa, Ravishankar Narayana, Cinzia M Bertea, Christopher T Rodgers, Massimo E Maffei
Variations in magnetic field (MF) intensity are known to induce plant morphological and gene expression changes. In Arabidopsis thaliana Col-0, near-null magnetic field (NNMF, i.e., <100 nT MF) causes a delay in the transition to flowering, but the expression of genes involved in this response has been poorly studied. Here, we showed a time-course quantitative analysis of the expression of both leaf (including clock genes, photoperiod pathway, GA20ox, SVP, and vernalization pathway) and floral meristem (including GA2ox, SOC1, AGL24, LFY, AP1, FD, and FLC) genes involved in the transition to flowering in A...
April 30, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29704215/population-pharmacokinetic-modeling-to-describe-the-total-plasma-and-free-brain-levels-of-fluconazole-in-healthy-and-cryptococcus-neoformans-infected-rats-how-does-the-infection-impact-the-drug-s-levels-on-biophase
#17
Izabel Almeida Alves, Keli Jaqueline Staudt, Fernando Olinto Carreño, Graziela de Araujo Lock, Carolina de Miranda Silva, Stela Maris Kuze Rates, Teresa Dalla Costa, Bibiana Verlindo De Araujo
PURPOSE: The present work aimed to evaluate the influence of experimental meningitis caused by C. neoformans on total plasma and free brain concentrations of fluconazole (FLC) in Wistar rats. METHOD: The infection was induced by the administration of 100 μL of inoculum (1.105  CFU) through the tail vein. Free drug in the brain was assessed by microdialisys (μD). Blood and μD samples were collected at pre-determined time points up to 12 h after intravenous administration of FLC (20 mg/kg) to healthy and infected rats...
April 27, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29683546/kappa-free-light-chains-in-cerebrospinal-fluid-to-identify-patients-with-oligoclonal-bands
#18
M Süße, M Hannich, A Petersmann, Stephanie Zylla, M Pietzner, M Nauck, A Dressel
OBJECTIVE: Gold standard for detection of intrathecal immunoglobulin synthesis is the measurement of oligoclonal bands (OCB). In the diagnosis of Multiple Sclerosis the kappa free light chains (KFLC) index has a similar sensitivity and specificity as OCB. This study investigated whether determination of the KFLC index could be used to predict the presence of OCB. METHODS: The KFLC index was determined prospectively from 295 paired serum and cerebrospinal fluid (CSF) samples...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29673601/decision-support-system-for-triage-management-a-hybrid-approach-using-rule-based-reasoning-and-fuzzy-logic
#19
Mahsa Dehghani Soufi, Taha Samad-Soltani, Samad Shams Vahdati, Peyman Rezaei-Hachesu
OBJECTIVES: Fast and accurate patient triage for the response process is a critical first step in emergency situations. This process is often performed using a paper-based mode, which intensifies workload and difficulty, wastes time, and is at risk of human errors. This study aims to design and evaluate a decision support system (DSS) to determine the triage level. METHODS: A combination of the Rule-Based Reasoning (RBR) and Fuzzy Logic Classifier (FLC) approaches were used to predict the triage level of patients according to the triage specialist's opinions and Emergency Severity Index (ESI) guidelines...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29660015/structural-basis-of-dna-target-recognition-by-the-b3-domain-of-arabidopsis-epigenome-reader-val1
#20
Giedrius Sasnauskas, Kotryna Kauneckaite, Virginijus Siksnys
Arabidopsis thaliana requires a prolonged period of cold exposure during winter to initiate flowering in a process termed vernalization. Exposure to cold induces epigenetic silencing of the FLOWERING LOCUS C (FLC) gene by Polycomb group (PcG) proteins. A key role in this epigenetic switch is played by transcriptional repressors VAL1 and VAL2, which specifically recognize Sph/RY DNA sequences within FLC via B3 DNA binding domains, and mediate recruitment of PcG silencing machinery. To understand the structural mechanism of site-specific DNA recognition by VAL1, we have solved the crystal structure of VAL1 B3 domain (VAL1-B3) bound to a 12 bp oligoduplex containing the canonical Sph/RY DNA sequence 5'-CATGCA-3'/5'-TGCATG-3'...
April 6, 2018: Nucleic Acids Research
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