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https://www.readbyqxmd.com/read/27921059/duodenal-recurrence-of-fibrolamellar-carcinoma-12-years-after-partial-hepatectomy-and-adjuvant-chemotherapy
#1
Héctor Adrián Díaz Hernández, Ismael Antonio Gómez Ruiz, Aldo Torre
Fibrolamellar carcinoma (FLC) has a better prognosis than hepatocellular carcinoma; however, it is a highly recurrent disease. A 17-year-old woman presented with FLC with regional disease at the right lobe of the liver and underwent right hepatic lobe resection plus adjuvant chemotherapy with interferon α and adriamycin. She then presented at age 29 years with anemia. Endoscopy revealed an exofitic lesion in the duodenum, which was a recurrence of FLC. The patient underwent duodenal partial resection of a metastatic FLC tumor with disease-free edges and without neural or lymphoid-vascular involvement, a nonreported site of recurrence...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27899552/prognostic-value-of-free-light-chains-lambda-and-kappa-in-early-multiple-sclerosis
#2
Margarete M Voortman, Tatjana Stojakovic, Lukas Pirpamer, Margit Jehna, Christian Langkammer, Hubert Scharnagl, Markus Reindl, Stefan Ropele, Thomas Seifert-Held, Juan-Jose Archelos, Siegrid Fuchs, Christian Enzinger, Franz Fazekas, Michael Khalil
BACKGROUND: Cerebrospinal fluid (CSF) immunoglobulin free light chains (FLC) have been suggested as quantitative alternative to oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS). However, little is known on their role in predicting clinical and paraclinical disease progression, particularly in early stages. OBJECTIVE: To assess the prognostic value of FLC in OCB-positive patients with clinically isolated syndrome (CIS) suggestive of MS and early MS...
November 29, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27898079/a-dna-element-that-remembers-winter
#3
Chenlong Li, Yuhai Cui
Polycomb-mediated silencing of the floral repressor gene FLC in response to long-term cold is a central event during vernalization in Arabidopsis thaliana, but how it is initiated is unclear. Two new studies identify a DNA element that mediates FLC silencing by attracting a pair of transcriptional repressors, VAL1 and VAL2, which in turn trigger epigenetic silencing by the Polycomb complex PHD-PRC2.
November 29, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27888009/a-novel-approach-for-the-chromatographic-purification-and-peptide-mass-fingerprinting-of-urinary-free-light-chains
#4
Bhupesh C Mali, Shamkant B Badgujar, Kunal K Shukla, Paresh B Bhanushali
We describe a chromatographic approach for the purification of urinary free light chains (FLCs) viz., lambda free light chains (λ-FLCs) and kappa free light chains (κ-FLCs). Isolated urinary FLCs were analyzed by SDS-PAGE, immunoblotting and mass spectrometry (MS). The relative molecular masses of λ-FLC and κ-FLC are 22,933.397 and 23,544.336Da respectively. Moreover, dimer forms of each FLC were also detected in mass spectrum which corresponds to 45,737.747 and 47,348.028Da respectively for λ-FLCs and κ-FLCs...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27885691/psychological-need-satisfaction-control-and-disordered-eating
#5
Franzisca V Froreich, Lenny R Vartanian, Matthew J Zawadzki, Jessica R Grisham, Stephen W Touyz
OBJECTIVES: Unfulfilled basic psychological needs have been associated with disordered eating behaviours, but the mechanisms underlying that associations are not well understood. This study examined a two-stage path model linking basic psychological need satisfaction to disordered eating behaviours via issues of control. METHODS: Female university students (N = 323; Mage  = 19.61), community participants (N = 371; Mage  = 29.75), and women who self-reported having been diagnosed with an eating disorder (ED; N = 41; Mage  = 23...
November 24, 2016: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27859214/adaptive-divergence-in-flowering-time-among-natural-populations-of-arabidopsis-thaliana-estimates-of-selection-and-qtl-mapping
#6
Jon Ågren, Christopher G Oakley, Sverre Lundemo, Douglas W Schemske
To identify the ecological and genetic mechanisms of local adaptation requires estimating selection on traits, identifying their genetic basis, and evaluating whether divergence in adaptive traits is due to conditional neutrality or genetic tradeoffs. To this end, we conducted field experiments for three years using recombinant inbred lines derived from two ecotypes of Arabidopsis thaliana (Italy, Sweden), and at each parental site examined selection on flowering time and mapped QTL. There was strong selection for early flowering in Italy, but weak selection in Sweden...
November 12, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27846293/assessment-of-intrathecal-free-light-chain-synthesis-comparison-of-different-quantitative-methods-with-the-detection-of-oligoclonal-free-light-chains-by-isoelectric-focusing-and-affinity-mediated-immunoblotting
#7
David Zeman, Pavlína Kušnierová, Zdeněk Švagera, František Všianský, Monika Byrtusová, Pavel Hradílek, Barbora Kurková, Olga Zapletalová, Vladimír Bartoš
OBJECTIVES: We aimed to compare various methods for free light chain (fLC) quantitation in cerebrospinal fluid (CSF) and serum and to determine whether quantitative CSF measurements could reliably predict intrathecal fLC synthesis. In addition, we wished to determine the relationship between free kappa and free lambda light chain concentrations in CSF and serum in various disease groups. METHODS: We analysed 166 paired CSF and serum samples by at least one of the following methods: turbidimetry (Freelite™, SPAPLUS), nephelometry (N Latex FLC™, BN ProSpec), and two different (commercially available and in-house developed) sandwich ELISAs...
2016: PloS One
https://www.readbyqxmd.com/read/27837087/dna-topoisomerase-i%C3%AE-affects-the-floral-transition
#8
Ximing Gong, Lisha Shen, Ya Zhi Peng, Yinbo Gan, Hao Yu
DNA topoisomerases modulate DNA topology to maintain chromosome superstructure and genome integrity, which is indispensable for DNA replication and RNA transcription. Their function in plant development still remains largely unknown. Here we report a hitherto unidentified role of Topoisomerase Iα (TOP1α) in controlling flowering time in Arabidopsis (Arabidopsis thaliana). Loss of function of TOP1α results in early flowering under both long and short days. This is mainly attributed to a decrease in the expression of a central flowering repressor FLOWERING LOCUS C (FLC) and its close homologs, MADS AFFECTING FLOWERING 4/5 (MAF4 and MAF5), during the floral transition...
November 11, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27819666/a-cis-cold-memory-element-and-a-trans-epigenome-reader-mediate-polycomb-silencing-of-flc-by-vernalization-in-arabidopsis
#9
Wenya Yuan, Xiao Luo, Zicong Li, Wannian Yang, Yizhong Wang, Rui Liu, Jiamu Du, Yuehui He
Some plants acquire competence to flower in spring after experiencing a seasonal temperature drop-winter cold, in a process termed vernalization. In Arabidopsis thaliana, prolonged exposure to cold induces epigenetic silencing of the potent floral repressor locus FLOWERING LOCUS C (FLC) by Polycomb group (PcG) proteins, and this silencing is stably maintained in subsequent growth and development upon return to warm temperatures. Here we show that a cis-regulatory DNA element in the nucleation region for PcG silencing at FLC and two homologous trans-acting epigenome readers, VAL1 and VAL2, control vernalization-mediated FLC silencing...
November 7, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27804118/elevated-levels-of-ferritin-in-the-cerebrospinal-fluid-of-amyotrophic-lateral-sclerosis-patients
#10
Y Zheng, L Gao, D Wang, D Zang
OBJECTIVES: The aim of the study was to detect changes in the levels of ferritin heavy chain (FHC), ferritin light chain (FLC), and transferrin in the cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients and to analyze the correlations between the levels of these proteins and various clinical parameters. METHODS: Cerebrospinal fluid and serum samples were obtained from 54 ALS patients and 46 non-inflammatory neurological disease control (non-INDC) patients...
November 1, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27775866/characterising-genes-associated-with-flowering-time-in-carrot-daucus-carota-l-using-transcriptome-analysis
#11
C-G Ou, J-H Mao, L-J Liu, C-J Li, H-F Ren, Z-W Zhao, F-Y Zhuang
Carrot is generally regarded as a biennial plant with an obligatory vernalization requirement. Early spring cultivation makes plants vulnerable to premature bolting, which results in a loss of commercial value. However, our knowledge of flowering time genes and flowering mechanisms in carrot remain limited. Bolting behavior of D. carota ssp. carota 'Songzi', a wild species sensitive to flower induction by vernalization and photoperiod, and orange cultivar 'Amsterdam forcing', and their offspring were investigated in different growing conditions...
October 24, 2016: Plant Biology
https://www.readbyqxmd.com/read/27735963/effect-of-novel-triazole-amino-acid-hybrids-on-growth-and-virulence-of-candida-species-in-vitro-and-in-vivo-studies
#12
Babita Aneja, Mohammad Irfan, Charu Kapil, Mohamad Aman Jairajpuri, Ronan Maguire, Kevin Kavanagh, M Moshahid A Rizvi, Nikhat Manzoor, Amir Azam, Mohammad Abid
The increasing incidence of human candidiasis and the tendency of Candida species to become resistant to existing chemotherapies are well-recognized health problems. The present study demonstrates the successful synthesis of novel triazole-amino acid hybrids with potent in vitro and in vivo inhibitory activity against Candida species. Particularly, compounds 68 and 70 showed potent in vitro activity against fluconazole (FLC) resistant as well as sensitive clinical isolates of Candida albicans. Time kill curve analysis of lead inhibitors 68 and 70 showed their fungistatic nature...
December 7, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27734231/the-significance-and-predictive-value-of-free-light-chains-in-the-urine-of-patients-with-chronic-inflammatory-rheumatic-disease
#13
Carsten Paul Bramlage, Britta Froelich, Manuel Wallbach, Joan Minguet, Clemens Grupp, Cornelia Deutsch, Peter Bramlage, Michael Koziolek, Gerhard Anton Müller
In patients with rheumatic diseases, reliable markers for determining disease activity are scarce. One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs in urine, a convenient source of test sample, in patients with different rheumatic diseases. We carried out a retrospective analysis of patients with rheumatic disease attending the University hospital of Goettingen, Germany...
October 12, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27729323/serum-free-light-chains-should-be-the-target-of-response-evaluation-in-light-chain-multiple-myeloma-rather-than-urines
#14
Thomas Dejoie, Jill Corre, Helene Caillon, Cyrille Hulin, Aurore Perrot, Denis Caillot, Eileen Boyle, Marie-Lorraine Chretien, Jean Fontan, Karim Belhadj, Sabine Brechignac, Olivier Decaux, Laurent Voillat, Philippe Rodon, Olivier Fitoussi, Carla Araujo, Lotfi Benboubker, Charlotte Fontan, Mourad Tiab, Pascal Godmer, Odile Luycx, Olivier Allangba, Jean-Michel Pignon, Jean-Gabriel Fuzibet, Laurence Legros, Anne-Marie Stoppa, Mamoun Dib, Brigitte Pegourie, Frederique Orsini-Piocelle, Lionel Karlin, Bertrand Arnulf, Murielle Roussel, Laurent Garderet, Mohamad Mohty, Nathalie Meuleman, Chantal Doyen, Pascal Lenain, Margaret Macro, Xavier Leleu, Thierry Facon, Philippe Moreau, Michel Attal, Herve Avet-Loiseau
Guidelines for monitoring multiple myeloma patients expressing light chains only (light chain multiple myeloma; LCMM) rely on measurements of the monoclonal protein in urine. Alternatively serum free light chain (sFLC) measurements have better sensitivity over urine methods, however, demonstration that improved sensitivity provides any clinical benefit is lacking. Here we compared the performance of serum and urine measurements in 113 (72κ, 41λ) newly diagnosed LCMM patients enrolled onto the IFM-2009 trial...
October 11, 2016: Blood
https://www.readbyqxmd.com/read/27721812/antiproliferation-of-berberine-in-combination-with-fluconazole-from-the-perspectives-of-reactive-oxygen-species-ergosterol-and-drug-efflux-in-a-fluconazole-resistant-candida-tropicalis-isolate
#15
Jing Shao, GaoXiang Shi, TianMing Wang, DaQiang Wu, ChangZhong Wang
Candida tropicalis has emerged as an important pathogenic fungus in nosocomial infections due to its recalcitrant resistance to conventional antifungal agents, especially to fluconazole (FLC). Berberine (BBR) is a bioactive herbal-originated alkaloids and has been reported to possess antifungal functions against C. albicans. In this paper, we tried to figure out the antifungal mechanisms of BBR and/or FLC in a clinical C. tropicalis isolate 2006. In the microdilution test, the minimum inhibitory concentration (MIC) of BBR was found 16 μg/mL with fractional inhibitory concentration index (FICI) 0...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27713408/mutually-exclusive-sense-antisense-transcription-at-flc-facilitates-environmentally-induced-gene-repression
#16
Stefanie Rosa, Susan Duncan, Caroline Dean
Antisense transcription through genic regions is pervasive in most genomes; however, its functional significance is still unclear. We are studying the role of antisense transcripts (COOLAIR) in the cold-induced, epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC), a regulator of the transition to reproduction. Here we use single-molecule RNA FISH to address the mechanistic relationship of FLC and COOLAIR transcription at the cellular level. We demonstrate that while sense and antisense transcripts can co-occur in the same cell they are mutually exclusive at individual loci...
October 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27698801/combined-use-of-free-light-chain-and-heavy-light-chain-ratios-allow-diagnosis-and-monitoring-of-patients-with-monoclonal-gammopathies-experience-of-a-single-institute-with-three-exemplar-case-reports
#17
Alfredo Gagliardi, Claudio Carbone, Angela Russo, Rosanna Cuccurullo, Anna Lucania, Paola Della Cioppa, Gabriella Misso, Michele Caraglia, Catello Tommasino, Lucia Mastrullo
Monoclonal gammopathies are characterized by serum monoclonal component (MC) plus an intact immunoglobulin and a free light chain (FLC), or a combination of both. The measurement of FLC with Freelite(®) is the standard practice recommended by International Myeloma Working Group guidelines. Recently, Hevylite(®) heavy/light chains (HLC) assays were introduced to specifically target junctional epitopes between the heavy and light chains of intact immunoglobulins, allowing the independent quantification of the involved (MC) and uninvolved (polyclonal immunoglobulin background) HLC isotype...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27696562/combined-antifungal-therapy-against-systemic-murine-infections-by-rare-cryptococcus-species
#18
Pamela Thomson, Emilio Mayayo, Loida López-Fernández, Josep Guarro, Javier Capilla
Cryptococcus albidus and Cryptococcus laurentii are uncommon species of this genus that in recent decades have increasingly caused opportunistic infections in humans, mainly in immunocompromised patients; the best therapy for such infection being unknown. Using a murine model of systemic infection by these fungi, we have evaluated the efficacy of amphotericin B (AMB) at 0.8 mg/kg, administered intravenously, fluconazole (FLC) or voriconazole (VRC), both administered orally, at 25 mg/kg and the combination of AMB plus VRC against three C...
October 3, 2016: Mycoses
https://www.readbyqxmd.com/read/27692179/molecular-interactions-between-flowering-time-and-abiotic-stress-pathways
#19
H J Park, W-Y Kim, J M Pardo, D-J Yun
Plants have adapted to environmental changes and stresses over generations. The decision of transition from the vegetative to reproductive stage is critical, particularly under unfavorable conditions. Thus, plants appear to have developed mechanisms by which environmental factors or inputs are transmitted to stress response signaling pathways to confer tolerance and are simultaneously integrated into flowering regulation pathways (photoperiod, vernalization, autonomous, and gibberellic acid signaling) to propagate the next generation...
2016: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/27682970/capillary-electrophoresis-immunosubtraction-as-a-better-alternative-to-immunofixation-for-detecting-and-immunotyping-serum-monoclonal-proteins-in-patients-with-immunoglobulin-light-chain-al-amyloidosis
#20
Kanji Miyazaki, Kenshi Suzuki
Capillary electrophoresis/immunosubtraction (CE/IS) is a simple method for detecting and immunotyping serum or urine monoclonal proteins. To our knowledge, there are no previous reports of the use of CE/IS for characterizing patients with Immunoglobulin light chain (AL) amyloidosis, and there are no convincing data available to compare CE/IS with serum immunofixation electrophoresis (IFE) and free light chain (FLC) assay. The aim of this study was to evaluate the clinical utility of CE/IS in patients with AL amyloidosis as a diagnostic accuracy study...
December 2016: Amyloid: the International Journal of Experimental and Clinical Investigation
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