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https://www.readbyqxmd.com/read/28214923/urinary-free-light-chains-may-help-to-identify-infection-in-patients-with-elevated-systemic-inflammation-due-to-rheumatic-disease
#1
Carsten P Bramlage, Britta Froelich, Manuel Wallbach, Joan Minguet, Clemens Grupp, Cornelia Deutsch, Peter Bramlage, Gerhard A Müller, Michael Koziolek
The risk of infection in patients with rheumatic diseases is elevated, but a clear marker to differentiate the cause of the systemic inflammation is missing. We assessed the ability urinary immunoglobulin free light chains (FLCs) to indicate the presence of infection in patients with rheumatic disease. We performed a retrospective analysis of patients with rheumatic disease attending the Georg-August University Hospital in Goettingen, Germany, from January 2011 to December 2013. Subjects were included if they had urine levels of κ and λ FLCs available...
February 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28210504/comparison-of-maximum-stretch-forces-between-femtosecond-laser-assisted-capsulotomy-and-continuous-curvilinear-capsulorhexis
#2
Mari Takagi, Takashi Kojima, Kei Ichikawa, Yoshiki Tanaka, Yukihito Kato, Rie Horai, Akeno Tamaoki, Kazuo Ichikawa
The current study reports comparing the postoperative mechanical properties of the anterior capsule between femtosecond laser capsulotomy (FLC) and continuous curvilinear capsulorhexis (CCC) of variable size and shape in porcine eyes. All CCCs were created using capsule forceps. Irregular or eccentric CCCs were also created to simulate real cataract surgery. For FLC, capsulotomies 5.3 mm in diameter were created using the LenSx® (Alcon) platform. Fresh porcine eyes were used in all experiments. The edges of the capsule openings were pulled at a constant speed using two L-shaped jigs...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28188267/phosphorylation-of-spt5-by-cdkd-2-is-required-for-vip5-recruitment-and-normal-flowering-in-arabidopsis-thaliana
#3
Chengyuan Lu, Yongke Tian, Shiliang Wang, Yanhua Su, Ting Mao, Tongtong Huang, Qingqing Chen, Zuntao Xu, Yong Ding
The elongation factor suppressor of Ty 5 homolog (Spt5) is a regulator of transcription and histone methylation. In humans, phosphorylation of SPT5 by P-TEFb, a protein kinase composed of Cyclin-dependent kinase 9 (CDK9) and cyclin T, interacts with the RNA polymerase II-associated factor1 (PAF1) complex. However, the mechanism of SPT5 phosphorylation is not well understood in plants. Here, we examine the function of SPT5 in Arabidopsis thaliana, and find that spt5 mutant flowers early under long-day and short-day conditions...
February 10, 2017: Plant Cell
https://www.readbyqxmd.com/read/28181910/clinical-usefulness-of-serum-free-light-chains-measurement-in-patients-with-multiple-myeloma-comparative-analysis-of-two-different-tests
#4
Tadeusz Kubicki, Dominik Dytfeld, Aleksandra Baszczuk, Ewa Wysocka, Mieczysław Komarnicki, Krzysztof Lewandowski
INTRODUCTION: There are two commercially available tests for measurement of serum free light chains (sFLC) in multiple myeloma (MM) patients - Freelite and N Latex FLC. The aim of this study was to perform an assessment and direct comparison of the usefulness of the methods in routine clinical practice. METHODS: 40 refractory/relapsed MM patients underwent routine disease activity assessment studies, along with sFLC analysis using both assays. Correlation and concordance between the tests and sensitivity of studied methods of sFLC assessment were established...
January 4, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28176517/regulation-of-erg3-erg6-and-erg11-genes-in-antifungal-resistant-isolates-of-candida-parapsilosis
#5
Ensieh Lotfali, Ali Ghajari, Parivash Kordbacheh, Farideh Zaini, Hossein Mirhendi, Rasoul Mohammadi, Fatemeh Noorbakhsh, Sassan Rezaie
Background: Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms. Method: The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined. The changes in the gene expression related to resistance were analyzed. Results: Eight strains were resistant to fluconazole (FLC), itraconazole (ITC), and amphotericin B (AMB)...
8, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28173754/genome-wide-analyses-of-four-major-histone-modifications-in-arabidopsis-hybrids-at-the-germinating-seed-stage
#6
Anyu Zhu, Ian K Greaves, Elizabeth S Dennis, W James Peacock
BACKGROUND: Hybrid vigour (heterosis) has been used for decades in cropping agriculture, especially in the production of maize and rice, because hybrid varieties exceed their parents in plant biomass and seed yield. The molecular basis of hybrid vigour is not fully understood. Previous studies have suggested that epigenetic systems could play a role in heterosis. RESULTS: In this project, we investigated genome-wide patterns of four histone modifications in Arabidopsis hybrids in germinating seeds...
February 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28165502/post-polyploidisation-morphotype-diversification-associates-with-gene-copy-number-variation
#7
Sarah Schiessl, Bruno Huettel, Diana Kuehn, Richard Reinhardt, Rod Snowdon
Genetic models for polyploid crop adaptation provide important information relevant for future breeding prospects. A well-suited model is Brassica napus, a recent allopolyploid closely related to Arabidopsis thaliana. Flowering time is a major adaptation trait determining life cycle synchronization with the environment. Here we unravel natural genetic variation in B. napus flowering time regulators and investigate associations with evolutionary diversification into different life cycle morphotypes. Deep sequencing of 35 flowering regulators was performed in 280 diverse B...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144822/in-vitro-activity-of-berberine-alone-and-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-trichosporon-asahii
#8
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients, with high mortality rates up to 80% despite treated with antifungal drugs. The biofilms-forming ability of T. asahii on indwelling medical devices may account for the resistance to antifungal drugs. Berberine (BBR) has been demonstrated to have antifungal activity and synergistic effects in combination with antifungal drugs against pathogenic fungi. In the present study, the in vitro activities of BBR alone or combined with fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), caspofungin (CAS) and amphotericin B (AMB) against planktonic forms and biofilms of 21 clinical T...
January 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28138121/activity-of-allyl-isothiocyanate-and-its-synergy-with-fluconazole-against-candida-albicans-biofilms
#9
Jayant Shankar Raut, Bhagyashree Shridhar Bansode, Ashwini Khanderao Jadhav, Sankunny Mohan Karuppayil
Candidiasis involving the biofilms of Candida albicans is a threat to the immunocompromised patients. Candida biofilms are intrinsically resistant to the antifungal drugs hence novel treatment strategies are desired. The study intended to evaluate the anti-Candida activity of allyl isothiocyanate (AITC) alone and with fluconazole (FLC), particularly against the biofilms. Results exhibit the concentration-dependent activity of AITC against the planktonic growth and virulence factors of C. albicans. Significant (p <0...
January 31, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28133872/comparison-of-two-in%C3%A2-vitro-antifungal-sensitivity-tests-and-monitoring-during-therapy-of-sporothrix-schenckii-sensu-stricto-in-malaysian-cats
#10
Hock Siew Han, Rui Kano, Charles Chen, Chiara Noli
BACKGROUND: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown. OBJECTIVES: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. METHODS: Sporothrix schenckii sensu stricto was isolated from 44 cats. Thermotolerance was determined via culture at 37°C for 7 days...
February 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28132848/vernalization-triggered-intragenic-chromatin-loop-formation-by-long-noncoding-rnas
#11
Dong-Hwan Kim, Sibum Sung
Long noncoding RNAs (lncRNAs) affect gene regulation through structural and regulatory interactions with associated proteins. The Polycomb complex often binds to lncRNAs in eukaryotes, and an lncRNA, COLDAIR, associates with Polycomb to mediate silencing of the floral repressor FLOWERING LOCUS C (FLC) during the process of vernalization in Arabidopsis. Here, we identified an additional Polycomb-binding lncRNA, COLDWRAP. COLDWRAP is derived from the repressed promoter of FLC and is necessary for the establishment of the stable repressed state of FLC by vernalization...
February 6, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28128051/functional-imaging-in-the-evaluation-of-diabetic-gastroparesis
#12
Prasanna Santhanam, Wael Marashdeh, Lilja B Solnes
Introduction Gastroparesis (a complication of both type 1 and type 2 diabetes mellitus) is delayed gastric emptying in the absence of a mechanical obstruction. Overall prevalence of Gastroparesis is close to 5 % in type 1 diabetes and 1 % in type 2 diabetes. It is unclear if good glycemic control leads to delay of development and progression of gastroparesis. Methods Gastric enteric neurons as well as interstitial cells of Cajal (ICC) are depleted, truncated and are surrounded by immune infiltrates composed of macrophages...
January 26, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28108812/fackel-interacts-with-gibberellic-acid-signaling-and-vernalization-to-mediate-flowering-in-arabidopsis
#13
Bingyao Huang, Pingping Qian, Na Gao, Jie Shen, Suiwen Hou
Fackel (FK) is involved in the flowering of Arabidopsis mainly via the gibberellin pathway and vernalization pathway. This new function of FK is partially dependent on the FLOWERING LOCUS C ( FLC ). A common transitional process from vegetative stage to reproductive stage exists in higher plants during their life cycle. The initiation of flower bud differentiation, which plays a key role in the reproductive phase, is affected by both external environmental and internal regulatory factors. In this study, we showed that the Arabidopsis weak mutant allele fk-J3158, impaired in the FACKEL (FK) gene, which encodes a C-14 reductase involved in sterol biosynthesis, had a long life cycle and delayed flowering time in different photoperiods...
January 20, 2017: Planta
https://www.readbyqxmd.com/read/28089540/aberrant-cdx2-expression-in-hepatocellular-carcinomas-an-important-diagnostic-pitfall
#14
Sejal S Shah, Tsung-Teh Wu, Michael S Torbenson, Vishal S Chandan
CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCC) that were CDX2 positive. CDX2 expression in HCC has not yet been reported but it has also not been examined in detail. Therefore, we evaluated CDX2 expression in a large number of resected HCCs. Full tumor sections from 172 resected HCCs and 6 resected fibrolamellar carcinomas (FLC) were stained for CDX2...
January 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28073158/antimicrobial-activity-and-mechanism-of-action-of-a-thionin-like-peptide-from-capsicum-annuum-fruits-and-combinatorial-treatment-with-fluconazole-against-fusarium-solani
#15
Gabriel B Taveira, Érica O Mello, André O Carvalho, Mariana Regente, Marcela Pinedo, Laura de La Canal, Rosana Rodrigues, Valdirene M Gomes
Many Fusarium species are able to cause severe infections in plants as well as in animals and humans. Therefore, the discovery of new antifungal agents is of paramount importance. CaThi belongs to the thionins, which are cationic peptides with low molecular weights (∼ 5 kDa) that have toxic effects against various microorganisms. Herein, we study the mechanism of action of CaThi and its combinatory effect with fluconazole (FLC) against Fusarium solani. The mechanism of action of CaThi was studied by growth inhibition, viability, plasma membrane permeabilization, ROS induction, caspase activation, localization and DNA binding capability, as assessed with Sytox green, DAB, FITC-VAD-FMK, CaThi-FITC and gel shift assays...
January 10, 2017: Biopolymers
https://www.readbyqxmd.com/read/28069658/scy-078-is-fungicidal-in-time-kill-studies-against-candida-species
#16
Bernard Scorneaux, David Angulo, Katyna Borroto-Esoda, Mahmoud Ghannoum, Michael Peel, Stephen Wring
SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpine antifungals in clinical development for treating candidemia and invasive candidiasis. In vitro susceptibility by broth micro-dilution, antifungal carry-over, and time-kill dynamics were determined for 3 reference (ATCC) strains (C. albicans 90028, C. parapsilosis 90018, and C. tropicalis 750), a Quality Control (QC) strain (C krusei 6258), and 4 other strains (C. albicans MYA-2732, 64124, 76485 and C...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28061989/high-risk-smoldering-myeloma-perspective-on-watchful-monitoring
#17
REVIEW
Siyang Leng, Suzanne Lentzsch
In a 2008 paper, Dispenzieri and colleagues at the Mayo Clinic proposed a risk stratification system for patients with smoldering multiple myeloma (SMM) based on the presence of three risk factors: serum M-protein ≥3 g/dL, bone marrow plasma cell percentage ≥10%, and a free light chain (FLC) ratio (κ to λ) of either ≤0.125 or ≥8. The patient in this vignette has all three risk factors, classifying him as high-risk, with an associated median time to progression (TTP) of 1.9 years. This is significantly worse than a patient with intermediate-risk (median TTP 5...
December 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/28053149/employment-of-methylene-blue-irradiated-with-laser-light-source-in-photodynamic-inactivation-of-biofilm-formed-by-candida-albicans-strain-resistant-to-fluconazole
#18
Lucia Černáková, Stanislava Dižová, Helena Bujdáková
A promising approach for the eradication of biofilm formed by the yeast Candida albicans seems to be photodynamic inactivation (PDI). This work presents a use of methylene blue (MB, 1 mM) irradiated with a red laser (output power 190 mW/cm(2), wavelength 660 nm) for the eradication of a biofilm formed by the fluconazole-resistant (FLC-resistant) strain C. albicans CY 1123 compared to the standard strain C. albicans SC5314. The periods of irradiation corresponded to the fluence of 15, 23 and 57 J/cm(2) Effectiveness of PDI was evident with following percentage of survived biofilm cells: 24...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28043263/-effect-of-fluorochloridone-on-oxidative-stress-in-primary-co-cultured-sertoli-germ-cell-of-rat
#19
S L Wu, L R Xu, Z J Zhou
Objective: To explore effect of fluorochloridone on primary co-cultured sertoli-germ cell of rat and its possible mechanism. Methods: primary co-cultured sertoli-germ cell was made by two steps of en-zyme digestion with SD rat testes, after 24h of Sertoli-germ cell isolation, A 0.1% DMSO solvent control group and three FLC exposure groups (10(-6)、10(-7)、10(-8) mol/L) were selected, cultured cell for 24h, then MTT assay and index detection of oxidative stress were performed. Results: The mortality of primary co-cultured sertoli-germ cell exposed to 10(-6) mol/L FLC was significantly higher than control group and FLC exposure groups (10(-7)、10(-8) mol/L) (P<0...
November 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28042077/symptom-burden-in-advanced-soft-tissue-sarcoma
#20
Nicholas Gough, Jonathan Koffman, Joy R Ross, Julia Riley, Ian Judson
CONTEXT: There is little information on symptom prevalence and severity in advanced soft-tissue sarcoma (STS). Understanding symptom burden will aid clinical consultations, clarify which symptom interventions are needed, and better define optimum timings of palliative and supportive care referrals. OBJECTIVES: To describe symptom prevalence and severity in patients undergoing different treatment options for advanced STS: 1) first-line palliative chemotherapy (FLC), 2) active surveillance (AS) pre- and post-FLC, and 3) palliative care (PC) alone...
December 29, 2016: Journal of Pain and Symptom Management
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