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https://www.readbyqxmd.com/read/28089540/aberrant-cdx2-expression-in-hepatocellular-carcinomas-an-important-diagnostic-pitfall
#1
Sejal S Shah, Tsung-Teh Wu, Michael S Torbenson, Vishal S Chandan
CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCC) that were CDX2 positive. CDX2 expression in HCC has not yet been reported but it has also not been examined in detail. Therefore, we evaluated CDX2 expression in a large number of resected HCCs. Full tumor sections from 172 resected HCCs and 6 resected fibrolamellar carcinomas (FLC) were stained for CDX2...
January 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28073158/antimicrobial-activity-and-mechanism-of-action-of-a-thionin-like-peptide-from-capsicum-annuum-fruits-and-combinatorial-treatment-with-fluconazole-against-fusarium-solani
#2
Gabriel B Taveira, Érica O Mello, André O Carvalho, Mariana Regente, Marcela Pinedo, Laura de La Canal, Rosana Rodrigues, Valdirene M Gomes
Many Fusarium species are able to cause severe infections in plants as well as in animals and humans. Therefore, the discovery of new antifungal agents is of paramount importance. CaThi belongs to the thionins, which are cationic peptides with low molecular weights (∼ 5 kDa) that have toxic effects against various microorganisms. Herein, we study the mechanism of action of CaThi and its combinatory effect with fluconazole (FLC) against Fusarium solani. The mechanism of action of CaThi was studied by growth inhibition, viability, plasma membrane permeabilization, ROS induction, caspase activation, localization and DNA binding capability, as assessed with Sytox green, DAB, FITC-VAD-FMK, CaThi-FITC and gel shift assays...
January 10, 2017: Biopolymers
https://www.readbyqxmd.com/read/28069658/scy-078-is-fungicidal-in-time-kill-studies-against-candida-species
#3
Bernard Scorneaux, David Angulo, Katyna Borroto-Esoda, Mahmoud Ghannoum, Michael Peel, Stephen Wring
SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpine antifungals in clinical development for treating candidemia and invasive candidiasis. In vitro susceptibility by broth micro-dilution, antifungal carry-over, and time-kill dynamics were determined for 3 reference (ATCC) strains (C. albicans 90028, C. parapsilosis 90018, and C. tropicalis 750), a Quality Control (QC) strain (C krusei 6258), and 4 other strains (C. albicans MYA-2732, 64124, 76485 and C...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28061989/high-risk-smoldering-myeloma-perspective-on-watchful-monitoring
#4
REVIEW
Siyang Leng, Suzanne Lentzsch
In a 2008 paper, Dispenzieri and colleagues at the Mayo Clinic proposed a risk stratification system for patients with smoldering multiple myeloma (SMM) based on the presence of three risk factors: serum M-protein ≥3 g/dL, bone marrow plasma cell percentage ≥10%, and a free light chain (FLC) ratio (κ to λ) of either ≤0.125 or ≥8. The patient in this vignette has all three risk factors, classifying him as high-risk, with an associated median time to progression (TTP) of 1.9 years. This is significantly worse than a patient with intermediate-risk (median TTP 5...
December 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/28053149/employment-of-methylene-blue-irradiated-with-laser-light-source-in-photodynamic-inactivation-of-biofilm-formed-by-candida-albicans-strain-resistant-to-fluconazole
#5
Lucia Černáková, Stanislava Dižová, Helena Bujdáková
A promising approach for the eradication of biofilm formed by the yeast Candida albicans seems to be photodynamic inactivation (PDI). This work presents a use of methylene blue (MB, 1 mM) irradiated with a red laser (output power 190 mW/cm(2), wavelength 660 nm) for the eradication of a biofilm formed by the fluconazole-resistant (FLC-resistant) strain C. albicans CY 1123 compared to the standard strain C. albicans SC5314. The periods of irradiation corresponded to the fluence of 15, 23 and 57 J/cm(2) Effectiveness of PDI was evident with following percentage of survived biofilm cells: 24...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28043263/-effect-of-fluorochloridone-on-oxidative-stress-in-primary-co-cultured-sertoli-germ-cell-of-rat
#6
S L Wu, L R Xu, Z J Zhou
Objective: To explore effect of fluorochloridone on primary co-cultured sertoli-germ cell of rat and its possible mechanism. Methods: primary co-cultured sertoli-germ cell was made by two steps of en-zyme digestion with SD rat testes, after 24h of Sertoli-germ cell isolation, A 0.1% DMSO solvent control group and three FLC exposure groups (10(-6)、10(-7)、10(-8) mol/L) were selected, cultured cell for 24h, then MTT assay and index detection of oxidative stress were performed. Results: The mortality of primary co-cultured sertoli-germ cell exposed to 10(-6) mol/L FLC was significantly higher than control group and FLC exposure groups (10(-7)、10(-8) mol/L) (P<0...
November 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28042077/symptom-burden-in-advanced-soft-tissue-sarcoma
#7
Nicholas Gough, Jonathan Koffman, Joy R Ross, Julia Riley, Ian Judson
CONTEXT: There is little information on symptom prevalence and severity in advanced soft tissue sarcoma (STS). Understanding symptom burden will aid clinical consultations, clarify which symptom interventions are needed and better define optimum timings of palliative and supportive care referrals. OBJECTIVES: To describe symptom prevalence and severity in patients undergoing different treatment options for advanced STS: [i] First-line palliative chemotherapy (FLC) [ii] Active surveillance (AS) pre and post-FLC and [iii] Palliative care (PC) alone...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28040409/antifungal-effects-of-phytocompounds-on-candida-species-alone-and-in-combination-with-fluconazole
#8
REVIEW
Mengjiao Lu, Tao Li, Jianjian Wan, Xiuyun Li, Lei Yuan, Shujuan Sun
Invasive fungal infections caused by Candida spp. remain the most predominant nosocomial fungal infections. Owing to the increased use of antifungal agents, resistance of Candida spp. to antimycotics has emerged frequently, especially to fluconazole (FLC). To cope with this issue, new efforts have been dedicated to discovering novel antimycotics or new agents that can enhance the susceptibility of Candida spp. to existing antimycotics. The secondary metabolites of plants represent a large library of compounds that are important sources for new drugs or compounds suitable for further modification...
December 15, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28036132/diagnostic-accuracy-of-salivary-and-serum-free-light-chain-assays-in-primary-sj%C3%A3-gren-s-syndrome-a-pilot-study
#9
Pulukool Sandhya, Pamela Christudoss, Jayakanthan Kabeerdoss, Santosh K Mandal, Ramya Aithala, Gowri Mahasampath, Victoria Job, Debashish Danda
OBJECTIVE: To estimate levels of salivary and serum free light chains (FLCs) and explore its utility as a biomarker in primary Sjögren's syndrome (pSS). METHODS: Patients with pSS classified by American European Consensus group 2002 or American College of Rheumatology 2012 criteria between January 2015 and August 2015 were included. Healthy staff and non-first degree relatives of patients constituted controls. Serum and salivary FLCs were measured by immunoturbidometry using FREELITE(™) Human Kappa(κ) and Lambda(λ) Free Kit (Binding site, Birmingham, UK), on a Roche Modular P800...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28034954/a-flowering-locus-c-homolog-is-a-vernalization-regulated-repressor-in-brachypodium-and-is-cold-regulated-in-wheat
#10
Neha Sharma, Philip Ruelens, Mariella Dhauw, Thomas Maggen, Niklas Dochy, Sanne Torfs, Kerstin Kaufmann, Antje Rohde, Koen Geuten
Winter cereals require prolonged cold to transition from vegetative to reproductive development. This process, referred to as vernalization, has been extensively studied in Arabidopsis thaliana. In Arabidopsis, a key flowering repressor called FLOWERING LOCUS C (FLC) quantitatively controls the vernalization requirement. By contrast, in cereals, the vernalization response is mainly regulated by the VERNALIZATION genes, VRN1 and VRN2. Here we characterize ODDSOC2, a recently identified FLC ortholog in monocots, for the first time knowing that it belongs to the FLC lineage...
December 29, 2016: Plant Physiology
https://www.readbyqxmd.com/read/28031206/physiological-differences-in-c-neoformans-in-vitro-versus-in-vivo-and-their-effects-on-antifungal-susceptibility
#11
Nina T Grossman, Arturo Casadevall
Cryptococcus neoformans is an environmentally ubiquitous fungal pathogen that primarily causes disease in people with compromised immune systems, particularly those with advanced AIDS. There are estimated to be almost one million cases per year of cryptococcal meningitis in patients with human immunodeficiency virus, leading to over 600,000 annual deaths, with a particular burden in sub-Saharan Africa. Amphotericin B (AMB) and fluconazole (FLC) are key components of cryptococcal meningitis treatment: AMB is used for induction, FLC for consolidation, maintenance, and in occasional individuals, prophylaxis...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28007919/delivery-of-parasite-rna-transcripts-into-infected-epithelial-cells-during-cryptosporidium-infection-and-its-potential-impact-on-host-gene-transcription
#12
Yang Wang, Ai-Yu Gong, Shibin Ma, Xiqiang Chen, Yan Li, Chun-Jen Su, Dana Norall, Jing Chen, Juliane K Strauss-Soukup, Xian-Ming Chen
Cryptosporidium parvum is an important opportunistic parasite pathogen for immunocompromised individuals and a common cause of diarrhea in young children. Previous studies have identified a panel of RNA transcripts of very low protein-coding potential in C. parvum Using an in vitro model of human intestinal cryptosporidiosis, we report here that some of these C. parvum RNA transcripts were selectively delivered into the nuclei of host epithelial cells during C. parvum infection. Nuclear delivery of several such parasitic RNAs, including Cdg7_FLc_0990, involved heat-shock protein 70-mediated nuclear importing mechanism...
December 22, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28007737/serum-flc-measurements-for-monitoring-mm
#13
(no author information available yet)
No abstract text is available yet for this article.
December 22, 2016: Blood
https://www.readbyqxmd.com/read/27999085/the-binding-specificity-of-phd-finger-domain-of-vin3-moderates-vernalization-response
#14
Donghawn Kim, Sibum Sung
Vernalization is a response to winter cold to initiate flowering in spring. VERNALIZATION INSENSITIVE 3 (VIN3) is induced by winter cold and is essential to vernalization response in Arabidopsis. VIN3 encodes a PHD-finger domain that binds to modified histones in vitro. An alteration in the binding specificity of the PHD-finger domain of VIN3 results in a hyper-vernalization response. The hyper-vernalization response is achieved by increased enrichments of VIN3 and tri-methylation of Histone H3 Lysine 27 at the FLC locus without invoking the increased enrichment of Polycomb Repressive Complex 2...
December 20, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27995877/-the-diagnostic-and-prognostic-values-of-serum-free-light-chain-in-patients-with-primary-light-chain-amyloidosis
#15
C L Zhang, J Feng, K N Shen, W Su, C L Zhang, X F Huang, X X Cao, L Zhang, D B Zhou, J Li
Objective: To investigate the diagnostic and prognostic values of serum free light chain (sFLC) in patients with primary light chain amyloidosis (pAL). Methods: Patients diagnosed with pAL between January 2009 and June 2015 at Peking Union Medical College Hospital were included in this study to retrospectively evaluate the clinical data, sFLC, treatment and survival. Results: In total, 126 newly diagnosed pAL patients with complete sFLC data were included in this study. The median age was 57 years old (range, 37-81 years) and male to female ratio was 1...
November 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27968983/aprf1-promotes-flowering-under-long-days-in-arabidopsis-thaliana
#16
Georgios Kapolas, Despoina Beris, Efthimia Katsareli, Pantelis Livanos, Aris Zografidis, Andreas Roussis, Dimitra Milioni, Kosmas Haralampidis
Arabidopsis thaliana flowering time mutants revealed the function of numerous genes that regulate the transition from vegetative to reproductive growth. Analyses of their loci have shown that many of them act as chromatin modifiers. In this study, a combination of molecular and genetic approaches have been implemented, to characterize the function of APRF1 (ANTHESIS POMOTING FACTOR 1) gene in A. thaliana and to investigate its role in plant development. APRF1 encodes for a low molecular weight nuclear WDR protein which displays functional homology to the Swd2 protein, an essential subunit of the yeast histone methylation COMPASS complex...
December 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27965280/longitudinal-systolic-strain-cardiac-function-improvement-and-survival-following-treatment-of-light-chain-al-cardiac-amyloidosis
#17
Francesco Salinaro, Hans K Meier-Ewert, Edward J Miller, Shivda Pandey, Vaishali Sanchorawala, John L Berk, David C Seldin, Frederick L Ruberg
AIMS: To determine whether echocardiographic longitudinal systolic strain (LS) parameters identify short-term improvement following chemotherapy for light-chain (AL) cardiac amyloidosis (CA). Among patients with CA, standard echocardiographic measures are commonly unchanged at 1 year following successful chemotherapy, despite observed reductions in cardiac biomarkers. METHODS AND RESULTS: We retrospectively identified 61 patients with AL-CA treated with high-dose melphalan or bortezomib-based regimens...
December 12, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27927996/post-translational-modifications-of-flowering-locus-c-modulate-its-activity
#18
REVIEW
Jun Soo Kwak, Ga Hyun Son, Jong Tae Song, Hak Soo Seo
Flowering Locus C (FLC) is a key floral repressor that precisely controls flowering time. The role of FLC has been extensively studied at the transcriptional level using molecular biological and epigenetic approaches. However, how FLC functions and how its stability is controlled at the post-translational level are only beginning to be understood. Recent studies show that various post-translational modifications (PTMs) control the stability and activity of FLC. In this review, we focus on three types of PTMs that regulate FLC function: phosphorylation, ubiquitination, and sumoylation...
December 7, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27925396/arabidopsis-sumo-protease-asp1-positively-regulates-flowering-time-partially-through-regulating-flc-stability
#19
Xiangxiong Kong, Xi Luo, Gao-Ping Qu, Peng Liu, Jing Bo Jin
The initiation of flowering is tightly regulated by the endogenous and environment signals, which is crucial for the reproductive success of flowering plants. It is well known that autonomous and vernalization pathways repress transcription of FLOWERING LOCUS C (FLC), a focal floral repressor, but how its protein stability is regulated remains largely unknown. Here, we found that mutations in a novel Arabidopsis SUMO protease 1 (ASP1) resulted in a strong late-flowering phenotype under long-days, but to a lesser extent under short-days...
December 7, 2016: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/27921059/duodenal-recurrence-of-fibrolamellar-carcinoma-12-years-after-partial-hepatectomy-and-adjuvant-chemotherapy
#20
Héctor Adrián Díaz Hernández, Ismael Antonio Gómez Ruiz, Aldo Torre
Fibrolamellar carcinoma (FLC) has a better prognosis than hepatocellular carcinoma; however, it is a highly recurrent disease. A 17-year-old woman presented with FLC with regional disease at the right lobe of the liver and underwent right hepatic lobe resection plus adjuvant chemotherapy with interferon α and adriamycin. She then presented at age 29 years with anemia. Endoscopy revealed an exofitic lesion in the duodenum, which was a recurrence of FLC. The patient underwent duodenal partial resection of a metastatic FLC tumor with disease-free edges and without neural or lymphoid-vascular involvement, a nonreported site of recurrence...
August 2016: ACG Case Reports Journal
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