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https://www.readbyqxmd.com/read/29923256/statins-a-role-in-breast-cancer-therapy
#1
REVIEW
Signe Borgquist, Olöf Bjarnadottir, Siker Kimbung, Thomas P Ahern
Statin drugs have been used for more than two decades to treat hypercholesterolemia and as cardio-preventive drugs, resulting in a marked decrease in cardiovascular morbidity and mortality worldwide. Statins halt hepatic cholesterol biosynthesis by inhibiting the rate-limiting enzyme in the mevalonate pathway, hydroxymethylglutaryl-coenzyme A reductase (HMGCR). The mevalonate pathway regulates a host of biochemical processes in addition to cholesterol production. Attenuation of these pathways is likely responsible for the myriad benefits of statin therapy beyond cholesterol reduction-the so-called pleiotropic effects of statins...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29915722/new-therapies-and-immunological-findings-in-cutaneous-t-cell-lymphoma
#2
REVIEW
Kazuyasu Fujii
Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Both diseases are considered T-helper cell type 2 (Th2) diseases. Not only the tumor cells but also the tumor microenvironment can promote Th2 differentiation, which is beneficial for the tumor cells because a Th1 environment enhances antitumor immune responses...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29915603/notch-signaling-in-myeloid-cells-as-a-regulator-of-tumor-immune-responses
#3
REVIEW
Fokhrul Hossain, Samarpan Majumder, Deniz A Ucar, Paulo C Rodriguez, Todd E Golde, Lisa M Minter, Barbara A Osborne, Lucio Miele
Cancer immunotherapy, which stimulates or augments host immune responses to treat malignancies, is the latest development in the rapidly advancing field of cancer immunology. The basic principles of immunotherapies are either to enhance the functions of specific components of the immune system or to neutralize immune-suppressive signals produced by cancer cells or tumor microenvironment cells. When successful, these approaches translate into long-term survival for patients. However, durable responses are only seen in a subset of patients and so far, only in some cancer types...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29914619/the-treatment-of-gliomas-in-adulthood
#4
Roland Goldbrunner, Maximilian Ruge, Martin Kocher, Carolin Weiss Lucas, Norbert Galldiks, Stefan Grau
BACKGROUND: Gliomas are the most common intrinsic tumors of the brain, with an incidence of 6 per 100 000 persons per year. Recent years have seen marked changes in the diagnosis and treatment of gliomas, with molecular parameters now being an integral part of the diagnostic evaluation. METHODS: This review is based on pertinent articles retrieved by a selective search in PubMed, with special attention to the new WHO glioma classification. RESULTS: The classification of gliomas on the basis of additional molecular parameters enables more accurate prognostication and serves as a basis for therapeutic decision-making and treatment according to precisely specified algorithms...
May 21, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29908123/cold-atmospheric-plasma-treatment-inhibits-growth-in-colorectal-cancer-cells
#5
Christin Schneider, Stephanie Arndt, Julia L Zimmermann, Yangfang Li, Sigrid Karrer, Anja-Katrin Bosserhoff
Plasma oncology is a relatively new field of research. Recent developments have indicated that cold atmospheric plasma (CAP) technology is an interesting new therapeutic approach to cancer treatment. In this study, p53 wildtype (LoVo) and human p53 mutated (HT29 and SW480) colorectal cancer cells were treated with the miniFlatPlaSter - a device particularly developed for the treatment of tumor cells - that uses the Surface Micro Discharge (SMD) technology for plasma production in air. The present study analyzed the effects of plasma on colorectal cancer cells in vitro and on normal colon tissue ex vivo...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29905756/tumor-treating-fields-time-for-demystification
#6
M Weller
No abstract text is available yet for this article.
June 14, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29900825/synchronous-but-separate-bladder-and-vaginal-rhabdomyosarcoma-a-novel-genetic-case-report
#7
Bradley A Morganstern, Samantha Scaccia, Wayland Wu, Alex K Williamson, Lane S Palmer
Embryonal rhabdomyosarcoma is a rare cancer that often requires multimodality therapy to treat; however, these therapies can cause changes in the biology of the tumor. Several reports have documented pathologic changes but only recently have genetic changes been mapped. We present case of two separate synchronous primary rhabdomyosarcomas in a 17-month-old patient and discuss the pathophysiology and genetic changes that occur with treatment. We hypothesize that a genetic field defect arising in development of the urogenital sinus caused the tumors, but that treatment modalities may have caused genetic alterations changing clinical behavior of the tumors and responses to treatment...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29900476/mixed-adenoneuroendocrine-carcinoma-of-the-esophagogastric-junction-a-case-report
#8
Miho Yamamoto, Soji Ozawa, Kazuo Koyanagi, Junya Oguma, Akihito Kazuno, Yamato Ninomiya, Kentaro Yatabe, Kazuhito Hatanaka
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a tumor of the gastrointestinal tract that contains both exocrine and endocrine components, with each component exceeding 30% of the total tumor area. Because MANECs are exceedingly rare, no therapeutic strategies have been established yet. CASE PRESENTATION: An 81-year-old man was referred to our hospital with a 5-month history of dysphagia. Esophagogastroduodenoscopy revealed an ulcerated mass in the lower thoracic esophagus, extending up to the esophagogastric junction (33 to 40 cm from the incisors)...
June 14, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29898747/recurrence-pattern-analysis-after-68-ga-dotatate-pet-ct-planned-radiotherapy-of-high-grade-meningiomas
#9
Barbara Zollner, Ute Ganswindt, Cornelius Maihöfer, Stefanie Corradini, Nathalie Lisa Albert, Christian Schichor, Claus Belka, Maximilian Niyazi
BACKGROUND: The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrence patterns. METHODS: Twenty patients with a neuropathological diagnosis of a high-grade meningioma (WHO°II or °III) treated with adjuvant or definitive radiotherapy between 2010 and 2015 were included in the present retrospective analysis. All patients were planned PET-based...
June 14, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29890894/stereotactic-body-radiotherapy-treatment-for-recurrent-previously-irradiated-head-and-neck-cancer
#10
Luke Stanisce, Yekaterina Koshkareva, Qianyi Xu, Ashish Patel, Christian Squillante, Nadir Ahmad, Kumar Rajagopalan, Gregory J Kubicek
PURPOSE: Locally recurrent, previously irradiated primary head and neck tumors have historically been associated with poor outcomes. Stereotactic body radiation therapy has emerged as a feasible and promising treatment option for tumor recurrence, particularly in nonsurgical candidates. This study aimed to assess the associated outcomes of stereotactic body radiation therapy used in this setting. METHODS: Retrospective analysis of a prospectively collected database of 25 patients treated with CyberKnife for unresectable, recurrent head and neck cancer in a previously irradiated field...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29874299/repeated-in-field-radiosurgery-for-locally-recurrent-brain-metastases-feasibility-results-and-survival-in-a-heavily-treated-patient-cohort
#11
Panagiotis Balermpas, Susanne Stera, Jens Müller von der Grün, Britta Loutfi-Krauss, Marie-Thérèse Forster, Marlies Wagner, Christian Keller, Claus Rödel, Volker Seifert, Oliver Blanck, Robert Wolff
PURPOSE: Stereotactic radiosurgery (SRS) is an established primary treatment for newly diagnosed brain metastases with high local control rates. However, data about local re-irradiation in case of local failure after SRS (re-SRS) are rare. We evaluated the feasibility, efficacy and patient selection characteristics in treating locally recurrent metastases with a second course of SRS. METHODS: We retrospectively evaluated patients with brain metastases treated with re-SRS for local tumor progression between 2011 and 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29863571/case-report-of-myeloid-sarcoma-masquerading-as-in-transit-metastasis-at-a-previous-melanoma-site-avoiding-a-diagnostic-pitfall
#12
Jonathan L Curry, Michael T Tetzlaff, Sa A Wang, Gene Landon, Nail Alouch, Sapna P Patel, Priyadharsini Nagarajan, Shiva Gupta, Phyu P Aung, Catherine E Devine, Joseph D Khoury, Sanam Loghavi, Victor G Prieto, Courtney D DiNardo, Jeffrey E Gershenwald
Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobiliary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies...
June 1, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29846300/long-term-survival-after-surgery-and-radiotherapy-for-recurrent-or-persistent-ovarian-and-tubal-cancer
#13
Robert Rome, Joanna Dipnall, Sam Leung
OBJECTIVE: This study examines the factors associated with long-term disease-specific survival (DSS) and complications after radiotherapy (RT) for recurrent or persistent ovarian and tubal cancer. METHODS/MATERIALS: Between 1980 and 2015, 65 women with ovarian (57), tubal (3), or co-existent ovarian/endometrial carcinoma (5) received RT (>45 Gy) with curative intent for recurrent (45) or persistent cancer (20) found at second-look surgery. Surgery to debulk (± restage) was integrated into the management of all but 7 cases...
May 24, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29846098/cytotoxicity-of-carboplatin-on-human-glioblastoma-cells-is-reduced-by-the-concomitant-exposure-to-an-extremely-low-frequency-electromagnetic-field-50-hz-70-g
#14
Maryam Amiri, Mohsen Basiri, Hossein Eskandary, Zeinab Akbarnejad, Marzie Esmaeeli, Yaser Masoumi-Ardakani, Meysam Ahmadi-Zeidabadi
Glioblastoma multiforme (GBM) is a malignant brain cancer that causes high mortality in patients. GBM responds weakly to the common cancer treatments such as chemotherapy and radiotherapy and even surgery. Carboplatin is an alkylating agent widely used to treat cancer. However, resistance to this drug is a common problem in its use in cancer treatment. Concomitant exposure to extremely low-frequency electromagnetic fields (ELF-EMFs) and carboplatin is one unexplored possibility for overcoming this resistance...
May 30, 2018: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/29813130/optimal-radiotherapy-strategy-for-primary-or-recurrent-fibromatosis-and-long-term-results
#15
Seo Hee Choi, Hong In Yoon, Seung Hyun Kim, Sang Kyum Kim, Kyoo-Ho Shin, Chang-Ok Suh
PURPOSE: Although locally invasive or recurrent fibromatosis is primarily treated with surgery, radiotherapy (RT) produces local control for recurrent/unresectable tumors or those with positive surgical margins. Herein, we describe our updated institutional experience with RT to treat fibromatosis. METHODS: Forty-seven patients with fibromatosis received RT between 1990 and 2015, and were followed for ≥12 months. Eight patients received RT for gross tumors, and 39 received postoperative RT after single/multiple prior surgeries...
2018: PloS One
https://www.readbyqxmd.com/read/29794110/genetics-informs-precision-practice-in-the-diagnosis-and-management-of-pheochromocytoma
#16
Hartmut P H Neumann, William Young, Tobias Krauss, Jean-Pierre Bayley, Francesca Schiavi, Giuseppe Opocher, Carsten Boedeker, Amit Tirosh, Frederic Castinetti, Juri Ruf, Dmitry Beltsevich, Martin K Walz, Harald Groeben, Ernst Von Dobschuetz, Oliver Gimm, Nelson Wohllk, Marija Pfeifer, Delmar Muniz Lourenço, Mariola Peczkowska, Attila Patocs, Joanne Ngeow, Ozer Makay, Nalini Shah, Arthur S Tischler, Helena Leijon, Gianmaria Pennelli, Karina Villar Gómez de Las Heras, Thera P Links, Birke Bausch, Charis Eng
Although the authors of the present review have contributed to genetic discoveries in the field of pheochromocytoma research, we can legitimately ask whether these advances have led to improvements in the diagnosis and management of patients with pheochromocytoma. The answer to this question is an emphatic Yes! In the field of molecular genetics, the well-established axiom that familial (genetic) pheochromocytoma represents 10% of all cases has been overturned, with >35% of cases now attributable to germline disease-causing mutations...
May 24, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29790485/bibliometric-analysis-of-tumor-immunotherapy-studies
#17
Kaining Lu, Shan Yu, Meng Yu, Dan Sun, Zhihong Huang, Haotian Xing, Jianbin Bi, Zeliang Li, Zhenhua Li, Xiankui Liu, Chuize Kong, Yuyan Zhu
BACKGROUND Cancer immunotherapy is the use of the immune system to treat cancer. After years of research, there have been a significant number of publications in this field. We analyzed the literature and performed a hotspot analysis to identify important areas of future scientific research. MATERIAL AND METHODS Articles (2945) related to cancer immunotherapy published in the past 3 years were selected as the research sample. BICOMB software was then used to retrieve the high-frequency words and construct a text/co-word matrix...
May 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29788940/two-cases-in-which-3d-mri-was-used-to-differentiate-between-a-disc-mass-that-mimics-a-tumor-and-neurinoma
#18
Jingyu Jia, Qiangqiang Wei, Tianlong Wu, Dingwen He, Xigao Cheng
BACKGROUND: Since disc sequestration that mimics a tumor is rare and sometimes presents with an atypical appearance upon magnetic resonance imaging (MRI), it is often confused with other more common epidural and intradural neoplasms, particularly neurinoma. Open surgery is necessary due to the difficult of achieving a definitive diagnosis using computed tomography, MRI, and gadolinium- enhanced MRI prior to operation. Herein, we describe the use of coronal MR images of 3D fast-field echo with water selective excitation in the diagnosis of disc sequestration mimicking a tumor...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29774663/dual-responsive-carbon-dot-for-ph-redox-triggered-fluorescence-imaging-with-controllable-photothermal-ablation-therapy-of-cancer
#19
Cheong A Choi, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Young Kwang Kim, Insik In, Ji Hoon Jeong, Sung Young Park
We described fluorescence resonance energy transfer for pH/redox-activatable fluorescent carbon dot (FNP) to realize "off-on" switched imaging-guided controllable photothermal therapy (PTT). The FNP is a carbonized self-crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions in cancer therapy. The capability for fluorescence bioimaging was achieved via the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds were reduced and benzoic imine were cleaved under acidic conditions...
May 18, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29772367/patterns-of-clinical-utilization-of-stereotactic-laser-ablation-sla-an-analysis-of-the-multi-center-prospective-registry
#20
Robert C Rennert, Usman Khan, Stephen B Tatter, Melvin Field, Brian Toyota, Peter E Fecci, Kevin Judy, Alireza M Mohammadi, Patrick Landazuri, Andrew Sloan, Eric Leuthardt, Clark C Chen
BACKGROUND: Stereotactic laser ablation (SLA), also termed laser interstitial thermal therapy (LITT), is a minimally invasive procedure that is increasingly utilized in neurosurgery. We wished to examine how/if SLA is changing the landscape of treatment options for neurosurgical patients. METHODS: Patients undergoing stereotactic laser ablation were prospectively enrolled in the Laser Ablation of Abnormal Neurological Tissue (LAANTERN) registry. Data from the first 100 enrolled patients are presented here...
May 14, 2018: World Neurosurgery
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