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https://www.readbyqxmd.com/read/29670880/targeting-tumor-associated-macrophages-as-a-potential-strategy-to-enhance-the-response-to-immune-checkpoint-inhibitors
#1
REVIEW
Luca Cassetta, Takanori Kitamura
Inhibition of immune checkpoint pathways in CD8+ T cell is a promising therapeutic strategy for the treatment of solid tumors that has shown significant anti-tumor effects and is now approved by the FDA to treat patients with melanoma and lung cancer. However the response to this therapy is limited to a certain fraction of patients and tumor types, for reasons still unknown. To ensure success of this treatment, CD8+ T cells, the main target of the checkpoint inhibitors, should exert full cytotoxicity against tumor cells...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29669122/a-shock-to-the-system-tumor-treating-fields-plus-temozolomide-for-glioblastoma
#2
Nikita Alexiades, Guy M McKhann
No abstract text is available yet for this article.
May 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29666669/-egfr-amplification-induces-sensitivity-to-anti-egfr-therapy-in-pancreatic-acinar-cell-carcinoma
#3
Corentin Richard, Julie Niogret, Romain Boidot, Francois Ghiringhelli
Pancreatic acinar cell carcinoma (PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses...
April 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29661142/neutrophils-in-primary-gastric-tumors-are-correlated-with-neutrophil-infiltration-in-tumor-draining-lymph-nodes-and-the-systemic-inflammatory-response
#4
Soichiro Hiramatsu, Hiroaki Tanaka, Junya Nishimura, Chie Sakimura, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based prognostic factor for gastric cancer. This study aimed to investigate the distribution of CD15+ neutrophils in the primary tumor and Tumor-Draining Lymph Nodes (TDLNs), and to examine the association of TANs with the clinicopathological features (including NLR) of patients with gastric cancer...
April 16, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29658357/analysis-of-clinical-data-to-determine-the-minimum-number-of-sensors-required-for-adequate-skin-temperature-monitoring-of-superficial-hyperthermia-treatments
#5
Akke Bakker, Rebecca Holman, Dario B Rodrigues, Hana Dobšíček Trefná, Paul R Stauffer, Geertjan van Tienhoven, Coen R N Rasch, Hans Crezee
PURPOSE: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients. METHODS: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with reirradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351-396 cm2 )...
April 16, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29656632/long-term-survival-in-patients-treated-with-a-robotic-radiosurgical-device-for-liver-metastases
#6
Sebastian Stintzing, Jobst von Einem, Christoph Fueweger, Alfred Haidenberger, Michael Fedorov, Alexander Muavcevic
Purpose: The treatment of liver metastases with local procedures is a fast progressing field. For the most, long-term survival data is missing raising questions with regard to the efficacy of such modalities when compared to surgical resection. Radiosurgery using the CyberKnife device enables the treatment of liver lesions with a single-session approach. Here we present long-term survival data to explore the curative potential of this strategy. Materials and Methods: Patients with oligo-metastatic disease limited to the liver have been treated with single-session or hypo-fractioned radiosurgery in curative intent and prospectively followed until death...
April 16, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29644485/acceptance-and-compliance-of-ttfields-treatment-among-high-grade-glioma-patients
#7
Julia Onken, Franziska Staub-Bartelt, Peter Vajkoczy, Martin Misch
BACKGROUND: Tumor treating fields (TTFields) significantly prolong both progression-free and overall survival in patients with newly diagnosed glioblastoma (GBM). TTFields are delivered to the brain tumor via skin transducer arrays and should be applied for a minimum of 18 h per day (≥ 75% compliance). This may cause limited acceptance by patients because of obstacles in daily routine. So far, there are limited data on factors influencing therapy acceptance and compliance. METHODS: In this retrospective study, fourty-one patients with primary GBM or recurrent high grade glioma (rHGG) have been treated with TTFields in our department...
April 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29644158/bilateral-simultaneous-temporal-relapses-of-medulloblastoma
#8
Mauricio Martinez-Moreno, Olga O Galván de la Cruz, Christian H Flores-Balcázar, Samuel Rosales-Pérez, Daniel Rembao-Bojórquez, Sergio Moreno-Jiménez
Supratentorial relapses are a common component of medulloblastoma after failure of treatment. Craniospinal irradiation (CSI) to cerebrospinal fluid-bearing areas is an essential part of the management of these tumors both in adults and children. Failure of treatment in specific anatomical regions can be attributable to technical inaccuracies in CSI technique leading to radiation underdosing in such areas. We present two cases of patients with bilateral simultaneous metastasis of a primary medulloblastoma treated, in both cases, four years before the recurrence...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29643953/individualized-laparoscopic-b-ultrasound-guided-microwave-ablation-for-multifocal-primary-liver-cancer
#9
Zhifeng Xu, Zhangwei Yang, Jianghua Pan, Yiren Hu
Introduction: Liver cancer is one of the most common malignancies of the digestive system. Minimally invasive ablation procedures have become one of the major means for treating unresectable multifocal liver cancer and have been extensively applied in primary and metastatic liver cancer treatment. Laparoscopic B-ultrasound-guided microwave ablation is an example of the progress made in this field. Aim: To analyze and summarize the results of and experience with laparoscopic B-ultrasound-guided microwave ablation for multifocal primary liver cancer; moreover, the ablation effects were compared between tumors of different sizes...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29643359/il23-and-tgf-%C3%A3-diminish-macrophage-associated-metastasis-in-pancreatic-carcinoma
#10
S Mazher Hussain, Leighton F Reed, Bradley A Krasnick, Gustavo Miranda-Carboni, Ryan C Fields, Ye Bi, Abul Elahi, Abidemi Ajidahun, Paxton V Dickson, Jeremiah L Deneve, William G Hawkins, David Shibata, Evan S Glazer
The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-ß expression in PDAC. We hypothesized that IL23 expression is associated with metastatic development and survival in PDAC. We investigated IL23 and TGF-ß protein expression on resected PDAC patient tumor sections who were divided into short-term (<12 months) survivors and long-term (>30 months) survivors...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29619980/targeting-myeloid-derived-suppressor-cells-and-programmed-death-ligand-1-confers-therapeutic-advantage-of-ablative-hypofractionated-radiation-therapy-compared-with-conventional-fractionated-radiation-therapy
#11
Jie Lan, Rui Li, Li-Mei Yin, Lei Deng, Jun Gui, Bao-Qing Chen, Lin Zhou, Mao-Bin Meng, Qiao-Rong Huang, Xian-Ming Mo, Yu-Quan Wei, Bo Lu, Adam Dicker, Jian-Xin Xue, You Lu
PURPOSE: Ablative hypofractionated radiation therapy (AHFRT) presents a therapeutic advantage compared with conventional fractionated radiation therapy (CFRT) for primary and oligometastatic cancers. However, the underlying mechanisms remain largely unknown. In the present study, we compared the immune alterations in response to AHFRT versus CFRT and examined the significance of immune regulations contributing to the efficacy of AHFRT. METHODS AND MATERIALS: We established subcutaneous tumors using syngeneic lung cancer and melanoma cells in both immunocompetent and immunocompromised mice and treated them with AHFRT and CFRT under the same biologically equivalent dose...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29615841/the-incidence-of-postoperative-radiotherapy-induced-acute-dermatitis-in-breast-cancer-and-its-influencing-factors-for-chinese-women
#12
Jingxian Ding, Yonghong Guo, Qingge Li, Jun Chen, Pinghua Hu, Qiuming Liu, Yali Cao, Jiong Wu
Purpose: To investigate the incidence of skin acute reaction and its influencing factors in postoperative breast cancer radiotherapy patients. Methods: One hundred and seventy three cases of breast cancer patients treated with postoperative radiotherapy were consecutively enrolled from June 1, 2016 to July 31, 2017 in our breast cancer center. Irradiation technology includes conformal intensity-modulated radiotherapy and a conventional two-dimensional one with conventional fraction...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29611210/interplay-effect-on-a-6-mv-flattening-filter-free-linear-accelerator-with-high-dose-rate-and-fast-multi-leaf-collimator-motion-treating-breast-and-lung-phantoms
#13
Tucker Netherton, Yuting Li, Paige Nitsch, Simona Shaitelman, Peter Balter, Song Gao, Ann Klopp, Manickam Muruganandham, Laurence Court
PURPOSE: Using a new linear accelerator with high dose rate (800 MU/min), fast MLC motions (5.0cm/s), fast gantry rotation (15sec/rotation), and 1cm wide MLCs, we aimed to quantify the effects of complexity, arc number, and fractionation on interplay for breast and lung treatments under target motion. METHODS: To study lung interplay, eight VMAT plans (one to six arcs) and four nine-field sliding-window IMRT plans varying in complexity were created. For the breast plans, four four-field sliding-window IMRT plans were created...
April 2, 2018: Medical Physics
https://www.readbyqxmd.com/read/29610941/pilot-in-vitro-and-in-vivo-study-on-a-mouse-model-to-evaluate-the-safety-of-transcutaneous-low-frequency-electrical-nerve-stimulation-on-cervical-cancer-patients
#14
Shiyan Wang, Xiuli Sun, Wenjin Cheng, Jue Zhang, Jianliu Wang
INTRODUCTION AND HYPOTHESIS: To clarify whether the pulse electrical field (PEF) caused by transcutaneous low-frequency nerve electrical stimulation (TENS) enhances the proliferation of cervical cancer cells, leading to recurrence and metastasis, and the effect of such a PEF on a cervical cancer mouse model. METHODS: 1. In vitro experiment: SiHa cervical cancer cells treated with one session of microsecond PEFs for 30 min were divided into four groups: three experimental groups and the control group...
April 2, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29607158/thoracoscopic-wedge-resection-in-single-lung-patients
#15
Davide Zampieri, Giuseppe Marulli, Giovanni Maria Comacchio, Marco Schiavon, Andrea Zuin, Federico Rea
Background: The thoracoscopic approach has become a standard procedure in the field of lung resections. However, its advantage in single-lung patients has not yet been well studied. We describe a series of successful thoracoscopic wedge resections in patients presenting with lung cancer after contralateral pneumonectomy. Methods: Eight patients, with a previous pneumonectomy (5 right and 3 left) for lung cancer, underwent resection for a suspicious neoplasm on the remaining lung...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606051/multistaged-multidirectional-strategy-for-safe-removal-of-large-meningiomas-in-the-pineal-region
#16
Naoki Otani, Kentaro Mori, Kojiro Wada, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi
OBJECTIVE Pineal region meningiomas are rare and tend to be discovered only after they grow. Several simultaneous multidirectional approaches performed as a single operation have been proposed, but the best strategy to remove these deeply situated large meningiomas involving the deep vital venous system remains to be established. The authors advocate a multistaged, multidirectional approach to safely remove these challenging tumors. METHODS Four consecutive cases of meningioma in the pineal region were treated between April 2013 and June 2016...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29597047/nanomagnetic-modulation-of-tumor-redox-state
#17
Valerii E Orel, Marina Tselepi, Thanos Mitrelias, Alexander Rykhalskyi, Andriy Romanov, Valerii B Orel, Anatoliy Shevchenko, Anatoliy Burlaka, Sergey Lukin, Crispin Barnes
Modulation of reactive oxygen and nitrogen species in a tumor could be exploited for nanotherapeutic benefits. We investigate the antitumor effect in Walker-256 carcinosarcoma of magnetic nanodots composed of doxorubicin-loaded Fe3 O4 nanoparticles combined with electromagnetic fields. Treatment using the magnetic nanodot with the largest hysteresis loop area (3402 erg/g) had the greatest antitumor effect with the minimum growth factor 0.49 ± 0.02 day-1 (compared to 0.58 ± 0.02 day-1 for conventional doxorubicin)...
March 26, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29594036/dosimetric-impact-of-a-tumor-treating-fields-device-for-glioblastoma-patients-undergoing-simultaneous-radiation-therapy
#18
Taoran Li, Gaurav Shukla, Cheng Peng, Virginia Lockamy, Haisong Liu, Wenyin Shi
Purpose: A recent randomized phase III clinical trial in patients with glioblastoma demonstrated the efficacy of tumor treating fields (TTFields), in which alternating electric fields are applied via transducer arrays to a patient's scalp. This treatment, when added to standard of care therapy, was shown to increase overall survival from 16 to 20.9 months. These results have generated significant interest in incorporating the use of TTFields during postoperative concurrent chemoradiation...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29589147/-primary-vitreoretinal-lymphoma
#19
D Jaehne, S E Coupland
Primary vitreoretinal lymphoma (PVRL) is the most common intraocular lymphoma. It is a high grade malignant B‑cell lymphoma, which is thought to arise in the retina. It often infiltrates the central nervous system (CNS) and is therefore associated with a poor prognosis. The PVRL must be differentiated from other forms of intraocular lymphoma, such as the low-grade B‑cell lymphoma that rarely arises in the choroid. The choroidal lymphomas do not spread to the brain, they can be treated with low-dose external beam radiotherapy and the patients have a good prognosis...
March 27, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29582943/-advances-in-the-treatment-of-retinoblastoma-at-hadassah-in-the-last-three-decades
#20
Shahar Frenkel, Michael Weintraub, Ido Rot, Naomi Shoshani, Jacob Pe'er
INTRODUCTION: Retinoblastoma (RB) is a malignant tumor presenting in the eyes of infants and children, which endangers life, the eye and vision. The treatment of RB has undergone marked changes in recent years, and great progress has been made in our ability to preserve eyes. Over the last three decades most Israeli patients with RB have been treated in the National Specialty Ocular Oncology Service at the Hadassah-Hebrew University Medical Center in Jerusalem. AIMS: To describe advances in the primary treatment of RB with an emphasis on eye-preserving treatments...
March 2018: Harefuah
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