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https://www.readbyqxmd.com/read/28338439/stereotactic-radiosurgery-in-the-treatment-of-parasellar-meningiomas-long-term-volumetric-evaluation
#1
Or Cohen-Inbar, Athreya Tata, Shayan Moosa, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE Parasellar meningiomas tend to invade the suprasellar, cavernous sinus, and petroclival regions, encroaching on adjacent neurovascular structures. As such, they prove difficult to safely and completely resect. Stereotactic radiosurgery (SRS) has played a central role in the treatment of parasellar meningiomas. Evaluation of tumor control rates at this location using simplified single-dimension measurements may prove misleading. The authors report the influence of SRS treatment parameters and the timing and volumetric changes of benign WHO Grade I parasellar meningiomas after SRS on long-term outcome...
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28336905/a-nanostructured-matrices-assessment-to-study-drug-distribution-in-solid-tumor-tissues-by-mass-spectrometry-imaging
#2
Silvia Giordano, Valentina Pifferi, Lavinia Morosi, Melinda Morelli, Luigi Falciola, Giuseppe Cappelletti, Sonja Visentin, Simonetta A Licandro, Roberta Frapolli, Massimo Zucchetti, Roberta Pastorelli, Laura Brunelli, Maurizio D'Incalci, Enrico Davoli
The imaging of drugs inside tissues is pivotal in oncology to assess whether a drug reaches all cells in an adequate enough concentration to eradicate the tumor. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) is one of the most promising imaging techniques that enables the simultaneous visualization of multiple compounds inside tissues. The choice of a suitable matrix constitutes a critical aspect during the development of a MALDI-MSI protocol since the matrix ionization efficiency changes depending on the analyte structure and its physico-chemical properties...
March 21, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336375/tumortropic-adipose-derived-stem-cells-carrying-smart-nanotherapeutics-for-targeted-delivery-and-dual-modality-therapy-of-orthotopic-glioblastoma
#3
Wen-Chia Huang, I-Lin Lu, Wen-Hsuan Chiang, Yi-Wen Lin, Yuan-Chung Tsai, Hsin-Hung Chen, Chien-Wen Chang, Chi-Shiun Chiang, Hsin-Cheng Chiu
Chemotherapy is typically used to treat malignant brain tumors, especially for the tumors in surgically inaccessible areas. However, owing to the existence of blood-brain barrier (BBB), the tumor accumulation and therapeutic efficacy of clinical therapeutics is still of great concerns. To this end, we present herein a prominent therapeutic strategy adopting adipose-derived stem cells (ADSCs) capable of carrying nanotherapeutic payloads selectively toward brain tumors for thermo/chemotherapy. The nanoparticle (NP) payload was obtained from co-assembly of poly(γ-glutamic acid-co-distearyl γ-glutamate) with poly(lactic-co-glycolic acid), paclitaxel (PTX), and oleic acid-coated superparamagnetic iron oxide NPs in aqueous solution...
March 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28331616/ex-vivo-akt-inhibition-promotes-the-generation-of-potent-cd19car-t-cells-for-adoptive-immunotherapy
#4
Ryan Urak, Miriam Walter, Laura Lim, ChingLam W Wong, Lihua E Budde, Sandra Thomas, Stephen J Forman, Xiuli Wang
BACKGROUND: Insufficient persistence and effector function of chimeric antigen receptor (CAR)-redirected T cells have been challenging issues for adoptive T cell therapy. Generating potent CAR T cells is of increasing importance in the field. Studies have demonstrated the importance of the Akt pathway in the regulation of T cell differentiation and memory formation. We now investigate whether inhibition of Akt signaling during ex vivo expansion of CAR T cells can promote the generation of CAR T cells with enhanced antitumor activity following adoptive therapy in a murine leukemia xenograft model...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28327623/long-term-effectiveness-of-irreversible-electroporation-in-a-murine-model-of-colorectal-liver-metastasis
#5
P Sánchez-Velázquez, Q Castellví, A Villanueva, M Iglesias, R Quesada, C Pañella, M Cáceres, D Dorcaratto, A Andaluz, X Moll, J M Burdío, L Grande, A Ivorra, F Burdío
Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with a high dose of IRE and which histological changes it induces in tumoral tissue, IRE ablation was performed in forty-six athymic-nude mice with KM12C tumors implanted in the liver by applying electric current with different voltages (2000 V/cm, 1000 V/cm). The tumors were allowed to continue to grow until the animals reached the end-point criteria...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326455/neutralization-of-mmp-2-and-tnfr1-regulates-the-severity-of-s-aureus-induced-septic-arthritis-by-differential-alteration-of-local-and-systemic-proinflammatory-cytokines-in-mice
#6
Sahin Sultana, Rana Adhikary, Biswadev Bishayi
Despite advancement in the field of antibiotics septic arthritis remains a serious concern till date. Staphylococcus aureus is the most common bacterium that causes septic arthritis. Severity of this disease is directly correlated with chronic inflammation induced by proinflammatory cytokines like TNF-α, interleukin (IL)-1β, IL-6, and induction of matrix metalloproteinases (MMPs) including MMP-2. The objective of our study was to evaluate the role of MMP-2 and tumor necrosis factor receptor 1 (TNFR1) in the pathogenesis of S...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28315947/impact-of-18-f-fdg-pet-ct-on-surgical-management-in-patients-with-advanced-melanoma-an-outcome-based-analysis
#7
Andrea Forschner, Susann-Cathrin Olthof, Brigitte Gückel, Peter Martus, Werner Vach, Christian la Fougère, Konstantin Nikolaou, Ulrike Keim, Thomas Kurt Eigentler, Claus Garbe, Christina Pfannenberg
PURPOSE: To evaluate the influence of (18)F-FDG-PET/CT on clinical decision making and outcome in advanced melanoma patients planned for radical metastasectomy. METHODS AND MATERIALS: A cohort of 333 patients with mainly stage III/IV melanoma having a PET/CT for clinical reasons was prospectively enrolled in our oncologic PET/CT registry between 2013 and 2015. Referring physicians completed questionnaires regarding their intended management for each patient before and after PET/CT...
March 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28303729/case-of-glioblastoma-patient-treated-with-tumor-treating-fields-therapy-at-recurrence-degenerating-to-sarcoma
#8
Pejman Majd, Daniel E O'Connell, Ronald C Kim, Daniela A Bota, Jose A Carrillo
Optune(®) treatment is a US FDA-approved treatment for glioblastoma (GBM) that employs alternating electric fields. Tumor treating field (TTF) therapy can exert its effects on GBM via cell cycle mitosis disruption and cytokinesis. We describe a patient with recurrent GBM who had disease progression following standard surgical treatment and concomitant chemoradiotherapy, and was found to have sarcomatous transformation after initiation of TTF therapy with bevacizumab. Upon tumor progression, repeat surgical resection revealed transformation into a GFAP-negative, reticulin-positive sarcoma with rhabdomyoid features...
March 17, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28303236/treating-the-critically-ill-with-radiotherapy-lessons-learned-from-a-young-woman-with-cardiac-angiosarcoma
#9
Emma C Fields, Bryan Squires, Harry Lomas
BACKGROUND: Treating patients who are critically ill with radiotherapy (RT) brings a unique set of challenges as it involves treating patients who require mechanical life support, unconventional positioning, and a multidisciplinary team approach to ensure safety. However, when the benefits of such treatment outweigh the risks, the challenges can be overcome, as demonstrated in this unique case of cardiac angiosarcoma. CASE DESCRIPTION: This is a case of a 42-year-old female with a right sided cardiac angiosarcoma who quickly developed cardiac tamponade and respiratory failure related to compression of her right heart by the tumor...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28302530/regorafenib-overcomes-chemotherapeutic-multidrug-resistance-mediated-by-abcb1-transporter-in-colorectal-cancer-in-vitro-and-in-vivo-study
#10
Yi-Jun Wang, Yun-Kai Zhang, Guan-Nan Zhang, Sweilem B Al Rihani, Meng-Ning Wei, Pranav Gupta, Xiao-Yu Zhang, Suneet Shukla, Suresh V Ambudkar, Amal Kaddoumi, Zhi Shi, Zhe-Sheng Chen
Chemotherapeutic multidrug resistance (MDR) is a significant challenge to overcome in clinic practice. Several mechanisms contribute to MDR, one of which is the augmented drug efflux induced by the upregulation of ABCB1 in cancer cells. Regorafenib, a multikinase inhibitor targeting the RAS/RAF/MEK/ERK pathway, was approved by the FDA to treat metastatic colorectal cancer and gastrointestinal stromal tumors. We investigated whether and how regorafenib overcame MDR mediated by ABCB1. The results showed that regorafenib reversed the ABCB1-mediated MDR and increased the accumulation of [(3)H]-paclitaxel in ABCB1-overexpressing cells by suppressing efflux activity of ABCB1, but not altering expression level and localization of ABCB1...
March 13, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28302222/-advances-in-the-treatment-of-relapsed-small-cell-lung-cancer
#11
Bin Liu, Jianwen Qin, Jingmin Zhou
Small cell lung cancer (SCLC) is a highly malignant tumor. The initial treatment of radiotherapy and chemotherapy are more sensitive, high remission rate, but susceptible to drug resistance and relapse after treatment. Although the treatment of lung cancer has undergone enormous changes in recent years, treatment for relapsed SCLC is still a difficult problem in clinical field. In view of the serious resistance of recurrent SCLC to the existing chemotherapeutic drugs, the research on recurrent SCLC around the world is focused on the clinical trial of new drug development, optimization of chemotherapy regimen and target drug development...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28301996/management-of-hepatocellular-carcinoma-prevention-surveillance-diagnosis-and-staging
#12
Digdem Ozer Etik, Nurettin Suna, Ahmet Sedat Boyacioglu
More than 600 000 people die from hepatocellular carcinoma each year. Worldwide, research on the disease needs to be intensified in both the medical and pharmaceutical fields, with a focus on providing help to geographic areas where resources are limited. Treatment approaches depend on the stage of the disease at diagnosis and on access to complex treatment regimens. However, advanced disease is not curable, and treating these patients is expensive and only marginally effective for increasing quality-adjusted life-years...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28301304/neuroprotective-and-therapeutic-effect-of-caffeine-on-the-rat-model-of-parkinson-s-disease-induced-by-rotenone
#13
Yasser A Khadrawy, Ahmed M Salem, Karima A El-Shamy, Emad K Ahmed, Nevein N Fadl, Eman N Hosny
The present study aimed to investigate the protective and therapeutic effects of caffeine on rotenone-induced rat model of Parkinson's disease (PD). Rats were divided into control, PD model induced by rotenone (1.5 mg/kg intraperitoneally (i.p.) for 45 days), protected group injected with caffeine (30 mg/kg, i.p.) and rotenone for 45 days (during the development of PD model), and treated group injected with caffeine (30 mg/kg, i.p.) for 45 days after induction of PD model. The data revealed a state of oxidative and nitrosative stress in the midbrain and the striatum of animal model of PD as indicated from the increased lipid peroxidation and nitric oxide levels and the decreased reduced glutathione level and activities of glutathione-S-transferase and superoxide dismutase...
September 3, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28298023/alternating-electric-tumor-treating-fields-for-treatment-of-glioblastoma-rationale-preclinical-and-clinical-studies
#14
Sandeep Mittal, Neil V Klinger, Sharon K Michelhaugh, Geoffrey R Barger, Susan C Pannullo, Csaba Juhász
OBJECTIVE Treatment for glioblastoma (GBM) remains largely unsuccessful, even with aggressive combined treatment via surgery, radiotherapy, and chemotherapy. Tumor treating fields (TTFs) are low-intensity, intermediate-frequency, alternating electric fields that have antiproliferative properties in vitro and in vivo. The authors provide an up-to-date review of the mechanism of action as well as preclinical and clinical data on TTFs. METHODS A systematic review of the literature was performed using the terms "tumor treating fields," "alternating electric fields," "glioblastoma," "Optune," "NovoTTF-100A," and "Novocure...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297307/development-and-evaluation-of-a-clinical-model-for-lung-cancer-patients-using-stereotactic-body-radiotherapy-sbrt-within-a-knowledge-based-algorithm-for-treatment-planning
#15
Karen Chin Snyder, Jinkoo Kim, Anne Reding, Corey Fraser, James Gordon, Munther Ajlouni, Benjamin Movsas, Indrin J Chetty
The purpose of this study was to describe the development of a clinical model for lung cancer patients treated with stereotactic body radiotherapy (SBRT) within a knowledge-based algorithm for treatment planning, and to evaluate the model performance and applicability to different planning techniques, tumor locations, and beam arrangements. 105 SBRT plans for lung cancer patients previously treated at our institution were included in the development of the knowledge-based model (KBM). The KBM was trained with a combination of IMRT, VMAT, and 3D CRT techniques...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28288673/using-field-size-factors-to-characterize-the-in-air-fluence-of-a-proton-machine-with-a-range-shifter
#16
Jiajian Shen, Jarrod M Lentz, Yanle Hu, Wei Liu, Danairis Hernandez Morales, Joshua B Stoker, Martin Bues
INTRODUCTION: The range shifter (RS) is used to treat shallow tumors for a proton pencil beam scanning system (PBS). Adding RS certainly complicates the commissioning of the treatment planning system (TPS) because the spot sizes are significantly enlarged with RS. In this work, we present an efficient method to configure a commercial TPS for a PBS system with a fixed RS. METHODS: By combining a spiral delivery with customized control points, we were able to significantly improve measurement efficiency and obtain 250 field size factors (FSF) within three hours...
March 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28286243/use-of-stereotactic-ablative-radiotherapy-sabr-in-non-small-cell-lung-cancer-measuring-more-than-5-cm
#17
Hilâl Tekatli, Saar van 't Hof, Esther J Nossent, Max Dahele, Wilko F A R Verbakel, Ben J Slotman, Suresh Senan
BACKGROUND: Stereotactic ablative radiotherapy (SABR) is currently not the guideline recommended treatment for lung tumors measuring more than 5 cm. However, improvements in radiotherapy techniques have led to an increasing use of SABR for larger tumors. METHODS: We analyzed the clinical outcomes in patients with a primary or recurrent non-small cell lung cancer measuring >5 cm, treated with 5 or 8 fractions of SABR at our center. Patients who had prior thoracic radiotherapy were excluded...
March 7, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28281173/glioma-subclassifications-and-their-clinical-significance
#18
REVIEW
Ricky Chen, Matthew Smith-Cohn, Adam L Cohen, Howard Colman
The impact of targeted therapies in glioma has been modest. All the therapies that have demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation, chemotherapy (temozolomide and PCV [procarbazine, lomustine, vincristine]), and tumor-treating fields, are based on nonspecific targeting of proliferating cells. Recent advances in the molecular understanding of gliomas suggest some potential reasons for the failure of more targeted therapies in gliomas. Specifically, the histologic-based glioma classification is composed of multiple different molecular subtypes with distinct biology, natural history, and prognosis...
March 9, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28281024/retinal-toxicity-after-cisplatin-based-chemotherapy-in-patients-with-germ-cell-cancer
#19
Simon Dulz, Niels H Asselborn, Klaus-Peter Dieckmann, Cord Matthies, Walter Wagner, Jens Weidmann, Christoph Seidel, Christoph Oing, Lars A Berger, Winfried Alsdorf, Blanche Mankichian, Christian Meyer, Malte W Vetterlein, Philipp Gild, Tim A Ludwig, Armin Soave, Philipp Schriefer, Andreas Becker, Sascha A Ahyai, Karin Oechsle, Carsten Bokemeyer, Lars Wagenfeld, Margit Fisch, Michael Hartmann, Felix K-H Chun, Luis A Kluth
PURPOSE: Visual impairment represents an infrequent form of cisplatin-induced neurotoxicity; however, visual deterioration has been reported in several studies. To evaluate potential morphological and functional retinal alterations in patients with germ cell cancer (GCC) treated with cisplatin-based chemotherapy (CBC). METHODS: Multi-disciplinary and multi-institutional study design. Examination of 28 eyes of 14 male GCC patients, who had received at least one cycle of CBC...
March 9, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28275683/colorectal-cancer-liver-metastasis-evolving-paradigms-and-future-directions
#20
REVIEW
Luai R Zarour, Sudarshan Anand, Kevin G Billingsley, William H Bisson, Andrea Cercek, Michael F Clarke, Lisa M Coussens, Charles E Gast, Cristina B Geltzeiler, Lissi Hansen, Katherine A Kelley, Charles D Lopez, Shushan R Rana, Rebecca Ruhl, V Liana Tsikitis, Gina M Vaccaro, Melissa H Wong, Skye C Mayo
In patients with colorectal cancer (CRC) that metastasizes to the liver, there are several key goals for improving outcomes including early detection, effective prognostic indicators of treatment response, and accurate identification of patients at high risk for recurrence. Although new therapeutic regimens developed over the past decade have increased survival, there is substantial room for improvement in selecting targeted treatment regimens for the patients who will derive the most benefit. Recently, there have been exciting developments in identifying high-risk patient cohorts, refinements in the understanding of systemic vs localized drug delivery to metastatic niches, liquid biomarker development, and dramatic advances in tumor immune therapy, all of which promise new and innovative approaches to tackling the problem of detecting and treating the metastatic spread of CRC to the liver...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
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