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https://www.readbyqxmd.com/read/29168899/global-scales-for-cognitive-screening-in-parkinson-s-disease-critique-and-recommendations
#1
REVIEW
Matej Skorvanek, Jennifer G Goldman, Marjan Jahanshahi, Connie Marras, Irena Rektorova, Ben Schmand, Erik van Duijn, Christopher G Goetz, Daniel Weintraub, Glenn T Stebbins, Pablo Martinez-Martin
BACKGROUND: Cognitive impairment is a common nonmotor manifestation of Parkinson's disease, with deficits ranging from mild cognitive difficulties in 1 or more of the cognitive domains to severe dementia. The International Parkinson and Movement Disorder Society commissioned the assessment of the clinimetric properties of cognitive rating scales measuring global cognitive performance in PD to make recommendations regarding their use. METHODS: A systematic literature search was conducted to identify the scales used to assess global cognitive performance in PD, and the identified scales were reviewed and rated as "recommended," "recommended with caveats," "suggested," or "listed" by the panel using previously established criteria...
November 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29168580/resveratrol-pterostilbene-and-dementia
#2
REVIEW
Klaus W Lange, Shiming Li
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia...
November 23, 2017: BioFactors
https://www.readbyqxmd.com/read/29168235/effects-of-nutraceuticals-on-sexual-satisfaction-and-lower-urinary-tract-symptoms-in-a-cohort-of-young-old-men
#3
Anna Perri, Alessandro Ilacqua, Marina Valenti, Antonio Aversa
The aim of this study was to evaluate the effects of nutraceuticals containing multiple supplemental facts (Virherbe®/Rekupros®) on sexual satisfaction and lower urinary tract symptoms (LUTS) in young-old men. In an open-label trial, 40 males (mean age 66 ± 13) with sexual disturbances and mild LUTS but without cognitive/motor impairment and clinical hypogonadism were enrolled. Sexual desire (SD; IIEF-SD domain) and satisfaction (Global Assessment Question; GAQ), the capacity to perform daily activities (evaluated by 6-min walking test [6MWT]), and International Prostate Symptoms Scores (IPSS) were evaluated before and after oral administration of 2 capsules/day of each supplement for 8 weeks...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29167639/disrupted-thalamus-white-matter-anatomy-and-posterior-default-mode-network-effective-connectivity-in-amnestic-mild-cognitive-impairment
#4
Thomas Alderson, Elizabeth Kehoe, Liam Maguire, Dervla Farrell, Brian Lawlor, Rose A Kenny, Declan Lyons, Arun L W Bokde, Damien Coyle
Alzheimer's disease (AD) and its prodromal state amnestic mild cognitive impairment (aMCI) are characterized by widespread abnormalities in inter-areal white matter fiber pathways and parallel disruption of default mode network (DMN) resting state functional and effective connectivity. In healthy subjects, DMN and task positive network interaction are modulated by the thalamus suggesting that abnormal task-based DMN deactivation in aMCI may be a consequence of impaired thalamo-cortical white matter circuitry...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29166674/unpredictable-chronic-mild-stress-differentially-impairs-social-and-contextual-discrimination-learning-in-two-inbred-mouse-strains
#5
Michiel van Boxelaere, Jason Clements, Patrick Callaerts, Rudi D'Hooge, Zsuzsanna Callaerts-Vegh
Alterations in the social and cognitive domain are considered important indicators for increased disability in many stress-related disorders. Similar impairments have been observed in rodents chronically exposed to stress, mimicking potential endophenotypes of stress-related psychopathologies such as major depression disorder (MDD), anxiety, conduct disorder, and posttraumatic stress disorder (PTSD). Data from numerous studies suggest that deficient plasticity mechanisms in hippocampus (HC) and prefrontal cortex (PFC) might underlie these social and cognitive deficits...
2017: PloS One
https://www.readbyqxmd.com/read/29165763/neuropsychological-intervention-of-minimal-cognitive-impairment-including-language-deficits
#6
Y Zhao, H Li
OBJECTIVE: Mild Cognitive Impairment (MCI) is an early dementia or discrete memory loss. The cognitive deficit in MCI impedes people's daily activities, which influences multiple aspects of thinking and acting including attention, reading, writing, reasoning, language, and judgment. This review aims to assess the outcome of various neuropsychological interventions in treating MCI. MATERIALS AND METHODS: MCI causes memory problems and is characterized by the cognitive damage that is disproportionate about individual education background and age...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165538/augmented-reality-sustaining-autonomous-way-finding-in-the-community-for-older-persons-with-cognitive-impairment
#7
K Sejunaite, C Lanza, S Ganders, A Iljaitsch, M W Riepe
BACKGROUND: Impairment of autonomous way-finding subsequent to a multitude of neurodegenerative and other diseases impedes independence of older persons and their everyday activities. OBJECTIVE: It was the goal to use augmented reality to aid autonomous way-finding in a community setting. DESIGN: A spatial map and directional information were shown via head-up display to guide patients from the start zone on the hospital campus to a bakery in the nearby community...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29165085/a-speech-recognition-based-solution-for-the-automatic-detection-of-mild-cognitive-impairment-from-spontaneous-speech
#8
Laszlo Toth, Ildiko Hoffmann, Gabor Gosztolya, Veronika Vincze, Greta Szatloczki, Zoltan Banreti, Magdolna Pakaski, Janos Kalman
BACKGROUND: Even today the reliable diagnosis of the prodromal stages of Alzheimer's disease (AD) remains a great challenge. Our research focuses on the earliest detectable indicators of cognitive decline in mild cognitive impairment (MCI). Since the presence of language impairment has been reported even in the mild stage of AD, the aim of this study is to develop a sensitive neuropsychological screening method which is based on the analysis of spontaneous speech production during performing a memory task...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29165083/subjective-spatial-navigation-complaints-a-frequent-symptom-reported-by-patients-with-subjective-cognitive-decline-mild-cognitive-impairment-and-alzheimer-s-disease
#9
Cerman Jiri, Andel Ross, Laczo Jan, Vyhnalek Martin, Nedelska Zuzana, Mokrisova Ivana, Sheardova Katerina, Hort Jakub
BACKGROUND: Great effort has been put into developing simple and feasible tools capable to detect Alzheimer's disease (AD) in its early clinical stage. Spatial navigation impairment occurs very early in AD and is detectable even in the stage of mild cognitive impairment (MCI). OBJECTIVE: The aim was to describe the frequency of self-reported spatial navigation complaints in patients with subjective cognitive decline (SCD), amnestic and non-amnestic MCI (aMCI, naMCI) and AD dementia and to assess whether a simple questionnaire based on these complaints may be used to detect early AD...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29165082/easy-screening-for-mild-alzheimer-s-disease-and-mild-cognitive-impairment-from-elderly-speech
#10
Shohei Kato, Akira Homma, Takuto Sakuma
OBJECTIVE: This study presents a novel approach for early detection of cognitive impairment in the elderly. The approach incorporates the use of speech sound analysis, multivariate statistics, and data-mining techniques. We have developed a speech prosody-based cognitive impairment rating (SPCIR) that can distinguish between cognitively normal controls and elderly people with mild Alzheimer's disease (mAD) or mild cognitive impairment (MCI) using prosodic signals extracted from elderly speech while administering a questionnaire...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29164603/18f-pet-with-florbetapir-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#11
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Xavier Bonfill Cosp, Leon Flicker
BACKGROUND: (18)F-florbetapir uptake by brain tissue measured by positron emission tomography (PET) is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using amyloid biomarkers tests like (18)F-florbetapir...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164602/18f-pet-with-flutemetamol-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#12
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Leon Flicker, Xavier Bonfill Cosp
BACKGROUND: (18)F-flutemetamol uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and the confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like (18)F-flutemetamol...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164600/18f-pet-with-florbetaben-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#13
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Leon Flicker, Xavier Bonfill Cosp
BACKGROUND: (18)F-florbetaben uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like (18)F-florbetaben...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164119/spontaneous-reversion-of-clinical-conditions-measuring-the-risk-profile-of-the-individual-from-frailty-to-mild-cognitive-impairment
#14
REVIEW
Marco Canevelli, Giuseppe Bruno, Francesca Remiddi, Carlo Vico, Eleonora Lacorte, Nicola Vanacore, Matteo Cesari
The number of people living with disabilities worldwide is rapidly growing due to a longer life expectancy and the subsequent increasing burden of chronic diseases. The need of developing and implementing effective strategies aimed at delaying or preventing disability has been repeatedly underlined and is currently the main focus of several health-care policies. In this scenario, a special attention is addressed to the identification of specific clinical conditions measuring the risk profile of the individual of developing an overt disability and other negative outcomes...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29163142/low-serum-phosphorus-correlates-with-cerebral-a%C3%AE-deposition-in-cognitively-impaired-subjects-results-from-the-kbase-study
#15
Jong-Chan Park, Sun-Ho Han, Min S Byun, Dahyun Yi, Jun Ho Lee, Kyua Park, Dong Young Lee, Inhee Mook-Jung
Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29162287/sustained-attention-in-school-age-children-with-congenital-hypothyroidism-influence-of-episodes-of-overtreatment-in-the-first-three-years-of-life
#16
L García Morales, M D Rodríguez Arnao, A Rodríguez Sánchez, E Dulín Íñiguez, M A Álvarez González
INTRODUCTION: Children with congenital hypothyroidism (CH) are at risk of developing mild cognitive impairment despite normal overall intellectual performance. These deficits may be caused by disease-related and treatment-related factors. This study explores the impact of abnormal thyroid function during the first 3 years of life on attention performance at school age. METHODS: We included 49 children diagnosed with CH and receiving treatment for the condition: 14 boys (mean age 9...
November 18, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29160740/effects-of-regular-physical-activity-on-the-cognitive-performance-of-type-2-diabetic-patients-a-systematic-review
#17
Natalie Podolski, Klara Brixius, Hans G Predel, Christian Brinkmann
BACKGROUND: Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS: PubMed was systematically searched for relevant publications up to July 2017. RESULTS: Four cross-sectional, one longitudinal observational, and nine interventional studies with a total of ∼7000 T2DM subjects are included in this review...
November 21, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29159812/the-i-in-autism-severity-and-social-functioning-in-autism-are-related-to-self-processing
#18
Karri Gillespie-Smith, Carrie Ballantyne, Holly P Branigan, David J Turk, Sheila J Cunningham
It is well established that children with autism spectrum disorder (ASD) show impaired understanding of others and deficits within social functioning. However, it is still unknown whether self-processing is related to these impairments and to what extent self impacts social functioning and communication. Using an ownership paradigm, we show that children with ASD and chronological- and verbal-age-matched typically developing (TD) children do show the self-referential effect in memory. In addition, the self-bias was dependent on symptom severity and socio-communicative ability...
November 21, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/29159268/olfactory-identification-in-subjective-cognitive-decline-and-mild-cognitive-impairment-association-with-tau-but-not-amyloid-positron-emission-tomography
#19
Shannon L Risacher, Eileen F Tallman, John D West, Karmen K Yoder, Gary D Hutchins, James W Fletcher, Sujuan Gao, David A Kareken, Martin R Farlow, Liana G Apostolova, Andrew J Saykin
Introduction: We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods: Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159266/analysis-of-macrolinguistic-aspects-of-narratives-from-individuals-with-alzheimer-s-disease-mild-cognitive-impairment-and-no-cognitive-impairment
#20
Cíntia Matsuda Toledo, Sandra Maria Aluísio, Leandro Borges Dos Santos, Sonia Maria Dozzi Brucki, Eduardo Sturzeneker Trés, Maira Okada de Oliveira, Letícia Lessa Mansur
Introduction: The depiction of features in discourse production promotes accurate diagnosis and helps to establish the therapeutic intervention in cognitive impairment and dementia. We aimed to identify alterations in the macrolinguistic aspects of discourse using a new computational tool. Methods: Sixty individuals, aged 60 years and older, were distributed in three different groups: mild Alzheimer's disease (mAD), amnestic mild cognitive impairment, and healthy controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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