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https://www.readbyqxmd.com/read/28926815/cognitive-function-and-walking-velocity-in-people-with-dementia-a-comparison-of-backward-and-forward-walking
#1
Hanna Johansson, Lillemor Lundin-Olsson, Håkan Littbrand, Yngve Gustafson, Erik Rosendahl, Annika Toots
How forward and backward walking, both central to everyday life, relate to cognition are relatively unexplored in people with dementia. This study aimed to investigate if forward and backward walking velocity respectively, associated with global cognition and executive function in people with dementia, and whether the association differed according to walking aid use or dementia type. Using a cross-sectional design, 161 participants (77% women), a mean Mini-Mental State Examination (MMSE) score of 15, and mean age of 85...
September 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28926416/blood-pressure-variability-and-cognitive-function-among-older-african-americans-introducing-a-new-blood-pressure-variability-measure
#2
Siny Tsang, Scott A Sperling, Moon Ho Park, Ira M Helenius, Ishan C Williams, Carol Manning
BACKGROUND: Although blood pressure (BP) variability has been reported to be associated with cognitive impairment, whether this relationship affects African Americans has been unclear. We sought correlations between systolic and diastolic BP variability and cognitive function in community-dwelling older African Americans, and introduced a new BP variability measure that can be applied to BP data collected in clinical practice. METHODS: We assessed cognitive function in 94 cognitively normal older African Americans using the Mini-Mental State Examination (MMSE) and the Computer Assessment of Mild Cognitive Impairment (CAMCI)...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28925738/psychometric-properties-of-the-saint-louis-university-mental-status-examination
#3
Susan K Shwartz, Robin D Morris, Suzanne Penna
The Saint Louis University Mental Status (SLUMS) Examination is a brief screening measure for mild neurocognitive disorder developed for use with veterans. To date, there has been a paucity of research on its psychometric properties. The purpose of this study is to evaluate the psychometric properties of the SLUMS in a referred sample to a specialty clinic. Using a sample of 148 male veterans referred to a Mild Cognitive Impairment (MCI) Clinic for evaluation, the ability of the SLUMS to discriminate between MCI versus Major Depressive Disorder (MDD) or no diagnosis was compared to results from a more comprehensive neuropsychological battery...
September 19, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28925333/depression-and-cognitive-function-in-mild-cognitive-impairment-a-1-year-follow-up-study
#4
Seoyoung Yoon, Cheolmin Shin, Changsu Han
BACKGROUND: The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in depression symptoms affect cognition longitudinally. METHODS: For the study, 161 patients with MCI were divided into a depressed group (D+) and a nondepressed group (D-)...
September 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28922966/plasma-lipids-metabolism-in-mild-cognitive-impairment-and-alzheimer-s-disease
#5
Alana C Costa, Helena P G Joaquim, Orestes Forlenza, Leda L Talib, Wagner F Gattaz
OBJECTIVES: Expression of phospholipids and related molecules could provide panels of multiple biomarkers searching for the signature of Alzheimer's disease (AD). The aim of the present study was to quantify ten phospholipids and simultaneously determine phospholipase A2 (PLA2) activity in blood of mild cognitive impairment (MCI) and AD patients. METHODS: Thirty-four AD, 20 MCI and 25 controls were enrolled. The phospholipids where analysed using the AbsoluteIDQ(®) p180 Kit...
September 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28922158/tailored-and-adaptive-computerized-cognitive-training-in-older-adults-at-risk-for-dementia-a-randomized-controlled-trial
#6
Alex Bahar-Fuchs, Shannon Webb, Lauren Bartsch, Linda Clare, George Rebok, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: Computerized Cognitive Training (CCT) has been shown to improve cognitive function in older adults with mild cognitive impairment (MCI) or mood-related neuropsychiatric symptoms (MrNPS), but many questions remain unresolved. OBJECTIVE: To evaluate the extent to which CCT benefits older adults with both MCI and MrNPS, and its effects on meta-cognitive and non-cognitive outcomes, as well as establish whether adapting difficulty levels and tailoring to individuals' profile is superior to generic training...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922157/longer-term-investigation-of-the-value-of-18f-fdg-pet-and-magnetic-resonance-imaging-for-predicting-the-conversion-of-mild-cognitive-impairment-to-alzheimer-s-disease-a-multicenter-study
#7
Yoshitaka Inui, Kengo Ito, Takashi Kato
BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and magnetic resonance imaging (MRI) for predicting conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD) in longer-term is unclear. OBJECTIVE: To evaluate longer-term prediction of MCI to AD conversion using 18F-FDG-PET and MRI in a multicenter study. METHODS: One-hundred and fourteen patients with MCI were followed for 5 years...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922154/atrial-fibrillation-is-independently-associated-with-cognitive-impairment-after-ischemic-stroke
#8
Russell Jude Chander, Levinia Lim, Sagarika Handa, Shaun Hiu, Angeline Choong, Xuling Lin, Rajinder Singh, Daniel Oh, Nagaendran Kandiah
BACKGROUND: While atrial fibrillation (AF) is an important risk factor for ischemic strokes and mild cognitive impairment (MCI) in Alzheimer's disease, the association between AF and post-stroke cognitive impairment (PSCI), and the factors mediating this association, is unclear. OBJECTIVE: To investigate the role of AF in PSCI, especially in relation to other markers of cerebrovascular disease. METHODS: 445 subjects with mild ischemic stroke without pre-stroke cognitive decline were assessed 3-6 months post-stroke for cognitive deficits...
September 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922149/the-relationships-between-components-of-metabolic-syndrome-and-mild-cognitive-impairment-subtypes-a-cross-sectional-study-of-japanese-older-adults
#9
Seongryu Bae, Hiroyuki Shimada, Sangyoon Lee, Hyuma Makizako, Sungchul Lee, Kazuhiro Harada, Takehiko Doi, Kota Tsutsumimoto, Ryo Hotta, Sho Nakakubo, Hyuntae Park, Takao Suzuki
BACKGROUND: The associations between components of metabolic syndrome (MetS) and mild cognitive impairment (MCI) subtypes remain unclear. OBJECTIVE: The study aim was to identify the prevalence of MetS for MCI subtypes and to investigate sex differences in the association between MetS and MCI subtypes in older Japanese adults. METHODS: The study analyzed data from 3,312 men and women aged 70 years or more. MetS was diagnosed according to International Diabetes Federation criteria...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922067/conceptual-elaboration-versus-direct-lexical-access-in-wais-similarities-differential-effects-of-white-matter-lesions-and-gray-matter-volumes
#10
Sven-Erik Fernaeus, Åke Hellström
Wechsler Adult Intelligence Scale (WAIS) subscale Similarities have been classified as a test of either verbal comprehension or of inductive reasoning. The reason may be that items divide into two categories. We tested the hypothesis of heterogeneity of items in WAIS-Similarities. Consecutive patients at a memory clinic and healthy controls participated in the study. White-matter hyperintensities (WMHs) and normalized temporal lobe volumes were measured based on Magnetic resonance Imaging (MRI), and tests of verbal memory and attention were used in addition to WAIS-Similarities to collect behavioural data...
September 18, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28920567/electronic-devices-for-cognitive-impairment-screening-a-systematic-literature-review
#11
J Antonio García-Casal, Manuel Franco-Martín, M Victoria Perea-Bartolomé, J Miguel Toribio-Guzmán, Carlos García-Moja, Miguel Goñi-Imizcoz, Emese Csipke
OBJECTIVES: The reduction in cognitive decline depends on timely diagnosis. The aim of this systematic review was to analyze the current available information and communication technologies-based instruments for cognitive decline early screening and detection in terms of usability, validity, and reliability. METHODS: Electronic searches identified 1,785 articles of which thirty-four met the inclusion criteria and were grouped according to their main purpose into test batteries, measures of isolated tasks, behavioral measures, and diagnostic tools...
September 18, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28920528/the-diagnostic-accuracy-of-the-montreal-cognitive-assessment-in-inpatient-stroke-rehabilitation
#12
Abhishek Jaywant, Joan Toglia, Faith M Gunning, Michael W O'Dell
The Montreal Cognitive Assessment (MoCA) is a commonly used screening measure for cognitive impairment; however, the diagnostic accuracy and optimal cutoff points in inpatients with mild stroke severity is unknown. We examined the diagnostic accuracy of the MoCA in an acute inpatient stroke rehabilitation unit (N = 95). The criterion neuropsychological assessment was the 30-minute National Institute of Neurological Disorders and Stroke-Canadian Stroke Network battery, modified to include the Symbol-Digit Modalities Test and Trail Making Test A & B...
September 18, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28919975/mild-cognitive-impairment-in-parkinson-s-disease-a-distinct-clinical-entity
#13
REVIEW
Ming-Ching Wen, Ling Ling Chan, Louis C S Tan, Eng King Tan
BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD-MCI) is a common clinical condition. Understanding its pathology and clinical features is important for early intervention before the onset of dementia. In the past, variable definitions and differences in neuropsychological batteries generated divergent results of the affected cognitive patterns. MAIN BODY: The introduction of PD-MCI criteria by the Movement Disorders Society (MDS) Task Force provides a more uniform system for defining and measuring PD-MCI and may improve the validity of future research...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28919857/divergent-roles-of-vascular-burden-and-neurodegeneration-in-the-cognitive-decline-of-geriatric-depression-patients-and-mild-cognitive-impairment-patients
#14
Qing Ye, Fan Su, Liang Gong, Hao Shu, Wenxiang Liao, Chunming Xie, Hong Zhou, Zhijun Zhang, Feng Bai
Both geriatric depression and mild cognitive impairment (MCI) confer an increased risk for the development of dementia. The mechanisms underlying the development of cognitive impairment in geriatric depression patients remain controversial. The present study aimed to explore the association of cognitive decline with vascular risk, white matter hyperintensity (WMH) burden and hippocampal volume in both remitted geriatric depression (RGD) subjects and amnestic mild cognitive impairment (aMCI) subjects. Forty-one RGD subjects, 51 aMCI subjects, and 64 healthy elderly subjects underwent multimodal MRI scans and neuropsychological tests at both baseline and a 35-month follow-up...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28919856/visualizing-hyperactivation-in-neurodegeneration-based-on-prefrontal-oxygenation-a-comparative-study-of-mild-alzheimer-s-disease-mild-cognitive-impairment-and-healthy-controls
#15
Kah Hui Yap, Wei Chun Ung, Esther G M Ebenezer, Nadira Nordin, Pui See Chin, Sandheep Sugathan, Sook Ching Chan, Hung Loong Yip, Masashi Kiguchi, Tong Boon Tang
Background: Cognitive performance is relatively well preserved during early cognitive impairment owing to compensatory mechanisms. Methods: We explored functional near-infrared spectroscopy (fNIRS) alongside a semantic verbal fluency task (SVFT) to investigate any compensation exhibited by the prefrontal cortex (PFC) in Mild Cognitive Impairment (MCI) and mild Alzheimer's disease (AD). In addition, a group of healthy controls (HC) was studied. A total of 61 volunteers (31 HC, 12 patients with MCI and 18 patients with mild AD) took part in the present study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28918757/relationship-between-cognitive-performance-and-measures-of-neurodegeneration-among-hispanic-and-white-non-hispanic-individuals-with-normal-cognition-mild-cognitive-impairment-and-dementia
#16
Shanna L Burke, Miriam J Rodriguez, Warren Barker, Maria T Greig-Custo, Monica Rosselli, David A Loewenstein, Ranjan Duara
OBJECTIVES: The aim of this study was to determine the presence and severity of potential cultural and language bias in widely used cognitive and other assessment instruments, using structural MRI measures of neurodegeneration as biomarkers of disease stage and severity. METHODS: Hispanic (n=75) and White non-Hispanic (WNH) (n=90) subjects were classified as cognitively normal (CN), amnestic mild cognitive impairment (aMCI) and mild dementia. Performance on the culture-fair and educationally fair Fuld Object Memory Evaluation (FOME) and Clinical Dementia Rating Scale (CDR) between Hispanics and WNHs was equivalent, in each diagnostic group...
September 18, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28915856/exercise-prescription-for-patients-with-multiple-sclerosis-potential-benefits-and-practical-recommendations
#17
Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian, Maryam Abolhasani
BACKGROUND: Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression. Patients with MS frequently decrease physical activity due to the fear from worsening the symptoms and this can result in reconditioning. Physicians now believe that regular exercise training is a potential solution for limiting the reconditioning process and achieving an optimal level of patient activities, functions and many physical and mental symptoms without any concern about triggering the onset or exacerbation of disease symptoms or relapse...
September 16, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28915800/association-of-body-mass-index-with-amnestic-and-non-amnestic-mild-cognitive-impairment-risk-in-elderly
#18
Feng Wang, Minghui Zhao, Zhaoli Han, Dai Li, Shishuang Zhang, Yongqiang Zhang, Xiaodong Kong, Ning Sun, Qiang Zhang, Ping Lei
BACKGROUND: Previous studies focused on the relationship between body mass index and cognitive disorder and obtained many conflicting results. This study explored the potential effects of body mass index on the risk of mild cognitive impairment (amnestic and non-amnestic) in the elderly. METHODS: The study enrolled 240 amnestic mild cognitive impairment patients, 240 non-amnestic mild cognitive impairment patients and 480 normal cognitive function controls. Data on admission and retrospective data at baseline (6 years ago) were collected from their medical records...
September 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28914221/-the-default-setting-of-memory-is-forgetting
#19
D Draaisma
From the age of about 60, many people begin to experience difficulties with tasks that require the use of prospective memory and begin to have trouble finding words and names. Worried that these symptoms may be indicative of the onset of Alzheimer's disease, many of them fill in online self-tests or consult their family doctor. In the vast majority of cases, symptoms like these indicate completely natural age-related forgetfulness. Physicians should encourage a socially active lifestyle to slow down further decline...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28914204/a-review-on-the-effects-of-testosterone-supplementation-in-hypogonadal-men-with-cognitive-impairment
#20
Mohamad Nur Vaizura, Soelaiman Ima-Nirwana, Kok-Yong Chin
Cognitive function and testosterone level of men decline concurrently with aging. Low testosterone levels are associated with higher risk of Alzheimer's disease and mild cognitive impairment in men. There are continuous debates on whether this relationship is casual or causal. This paper aims to summarize the current evidence on the association between testosterone level and cognitive function in elderly men. The presence of testosterone, androgen receptor and its responsive genes hint that testosterone has biological functions in the central nervous system...
September 13, 2017: Current Drug Targets
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