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https://www.readbyqxmd.com/read/29792874/pet-staging-of-amyloidosis-using-striatum
#1
Bernard J Hanseeuw, Rebecca A Betensky, Elizabeth C Mormino, Aaron P Schultz, Jorge Sepulcre, John A Becker, Heidi I L Jacobs, Rachel F Buckley, Molly R LaPoint, Patrizia Vanini, Nancy J Donovan, Jasmeer P Chhatwal, Gad A Marshall, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Reisa A Sperling, Keith A Johnson
INTRODUCTION: Amyloid PET data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a three-stage PET classification: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid; hypothesizing this model could better reflect Alzheimer's dementia progression than a model based only on cortical measures. METHODS: We classified PET data from 1433 participants (646 normal, 574 mild cognitive impairment, and 213 AD), explored the successive involvement of cortex and striatum using 3-year follow-up PET data, and evaluated the associations between PET stages, hippocampal volumes, and cognition...
May 21, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29791634/effects-of-health-education-in-the-elderly-with-mild-cognitive-impairment
#2
Francine Golghetto Casemiro, Diana Monteiro Quirino, Maria Angélica Andreotti Diniz, Rosalina Aparecida Partezani Rodrigues, Sofia Cristina Iost Pavarini, Aline Cristina Martins Gratão
OBJECTIVE: to analyze the effects of health education on both cognition and depressive/anxiety symptoms in the elderly with Mild Cognitive Impairment (MCI). METHOD: this is a randomized and controlled clinical trial. Participants (n=22) were recruited from a specialized outpatient clinic, and assigned into two groups: a Health Education Group (HEG) (n=10) and a Control Group (CG) (n=12). The participants were evaluated before and after the intervention, which was composed of classes and dynamics...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791460/are-saving-appearance-responses-typical-communication-patterns-in-alzheimer-s-disease
#3
Masateru Matsushita, Yusuke Yatabe, Asuka Koyama, Akiko Katsuya, Daisuke Ijichi, Yusuke Miyagawa, Hiroto Ikezaki, Noboru Furukawa, Manabu Ikeda, Mamoru Hashimoto
INTRODUCTION: To keep up appearances, people with dementia sometimes pretend to know the correct answer, as seen during administration of neuropsychological tests such as the Mini-Mental State Examination (MMSE). These saving appearance responses (SARs) of people with dementia often lead to caregivers and/or medical staff underestimating the severity of dementia and impede proper early initiation of treatment. However, most descriptions of SARs are based on empirical knowledge of clinicians...
2018: PloS One
https://www.readbyqxmd.com/read/29790690/validation-of-the-portuguese-version-of-addenbrooke-s-cognitive-examination-iii-in-mild-cognitive-impairment-and-dementia
#4
Bruno Peixoto, Milene Machado, Patricia Rocha, Carla Macedo, António Machado, Élia Baeta, Gerly Gonçalves, Paulo Pimentel, Emanuela Lopes, Luis Monteiro
BACKGROUND: Cognitive assessment is central to the diagnosis of cognitive impairment and dementia, and it should be performed in all patients in the early stages of the disease. Recently, the 3rd version of Addenbrooke's Cognitive Examination (ACE-III) has been developed in order to improve the previous versions. OBJECTIVES: The aim of this study was to determine the psychometric properties of the Portuguese version of ACE-III, namely: reliability and discriminative validity (sensitivity and specificity) in the identification of mild cognitive impairment (MCI) and dementia, in comparison to other neuropsychological screening tests, as well as to establish its concurrent and divergent validity...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790638/comparative-efficacy-and-acceptability-of-anti-diabetic-agents-for-alzheimer-s-disease-and-mild-cognitive-impairment-a-systematic-review-and-network-meta-analysis
#5
Bing Cao, Joshua D Rosenblat, Elisa Brietzke, Caroline Park, Yena Lee, Natalie Musial, Zihang Pan, Rodrigo B Mansur, Roger S McIntyre
The current meta-analysis compares the efficacy (i.e., pro-cognitive effects) and acceptability of anti-diabetic agents for Alzheimer's disease (AD) and mild cognitive impairment (MCI). Cochrane Library (CENTRAL), PubMed/MEDLINE, EMBASE and PsycINFO were searched from inception to January 15, 2018 for randomized controlled trials (RCTs) comparing anti-diabetic agents with placebo and/or another active anti-diabetic agent for the treatment of AD or MCI. Nineteen eligible studies (n = 4,855) evaluating the effects of six different anti-diabetic drugs (i...
May 23, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29789032/neuropsychological-correlates-of-instrumental-activities-of-daily-living-in-neurocognitive-disorders-a-possible-role-for-executive-dysfunction-and-mood-changes
#6
Martina Amanzio, Sara Palermo, Milena Zucca, Rosalba Rosato, Elisa Rubino, Daniela Leotta, Massimo Bartoli, Innocenzo Rainero
ABSTRACTSince baseline executive dysfunction predicts worsening Instrumental Activities of Daily Living (i-ADL) over time and progression to Alzheimer's Disease (AD), we aimed to analyze the role of neuropsychological variables to outline which factors can contribute to functional impairment. Specific attention to executive functions (EFs) has been given.A total of 144 subjects complaining of different cognitive deficits - ranging from "MCI likely due to AD" to "mild AD patients" - underwent an overall neuropsychological assessment...
May 23, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29788232/chronic-stress-exposure-reduces-parvalbumin-expression-in-the-rat-hippocampus-through-an-imbalance-of-redox-mechanisms-restorative-effect-of-the-antipsychotic-lurasidone
#7
Andrea C Rossetti, Maria Serena Paladini, Martina Colombo, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Mariusz Papp, Marco A Riva, Raffaella Molteni
Background: Psychiatric disorders are associated with altered function of inhibitory neurotransmission within the limbic system, which may be due to the vulnerability of selective neuronal subtypes to challenging environmental conditions, such as stress. In this context, parvalbumin (PVB) positive GABAergic interneurons, which are critically involved in processing complex cognitive tasks, are particularly vulnerable to stress exposure, an effect that may be the consequence of dysregulated redox mechanisms...
May 18, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29788013/cerebrospinal-fluid-bace1-activity-and-sa%C3%AE-pp%C3%AE-as-biomarker-candidates-of-alzheimer-s-disease
#8
Panagiotis Alexopoulos, Nathalie Thierjung, Timo Grimmer, Marion Ortner, Polychronis Economou, Konstantinos Assimakopoulos, Philippos Gourzis, Antonios Politis, Robert Perneczky
BACKGROUND/AIMS: The utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive. METHODS: BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48)...
May 22, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29787954/the-effectiveness-of-a-cognitive-training-program-in-people-with-mild-cognitive-impairment-a-study-in-urban-community
#9
Chalermpong Sukontapol, Sasithorn Kemsen, Sirintorn Chansirikarn, Daochompu Nakawiro, Orawan Kuha, Unchulee Taemeeyapradit
OBJECTIVE: To assess the effectiveness of a cognitive training program on global cognition among people with mild cognitive impairment. METHODS: In this experimental study, using purposive sampling, 60 participants age 50 years and over who complained of subjective memory impairment were screened in their communities by public health volunteers with the Abbreviated Mental Test. Those with dementia were excluded as well as those with depression, which were screened out by the Thai Geriatric Depression Scale (TGDS-15)...
May 19, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29787739/apathy-in-individuals-with-parkinson-s-disease-associated-with-mild-cognitive-impairment-a-neuropsychological-investigation
#10
Alberto Costa, Antonella Peppe, Silvia Zabberoni, Francesco Scalici, Carlo Caltagirone, Giovanni Augusto Carlesimo
Apathy is frequently reported in individuals with Parkinson's disease (PD) and is hypothesized to be associated with frontal-striatal related cognitive functions. Available data, however, do not provide univocal results. Moreover, this relationship has been poorly investigated in PD patients with mild cognitive impairment (MCI). This study was aimed at investigating the association between severity of apathy of PD patients and their performance on neuropsychological tests investigating executive abilities. Individuals with PD (i...
May 19, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29785710/insomnia-in-community-living-persons-with-advanced-age
#11
Brienne Miner, Thomas M Gill, H Klar Yaggi, Nancy S Redeker, Peter H Van Ness, Ling Han, Carlos A Vaz Fragoso
OBJECTIVE: To evaluate the epidemiology of insomnia, including demographic and clinical correlates, in older adults. DESIGN: Cross-sectional. SETTING: Community. PARTICIPANTS: Yale Precipitating Events Project participants (N=379; mean age 84.3; 67.8% female; 11.9% African American). MEASUREMENTS: Insomnia Severity Index (ISI), with scores of 8 and higher indicating insomnia, which was further stratified according to ISI score as mild (8-14), moderate (15-21), or severe (22-28)...
May 21, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29785624/longitudinal-neuroimaging-hippocampal-markers-for-diagnosing-alzheimer-s-disease
#12
Carlos Platero, Lin Lin, M Carmen Tobar
Hippocampal atrophy measures from magnetic resonance imaging (MRI) are powerful tools for monitoring Alzheimer's disease (AD) progression. In this paper, we introduce a longitudinal image analysis framework based on robust registration and simultaneous hippocampal segmentation and longitudinal marker classification of brain MRI of an arbitrary number of time points. The framework comprises two innovative parts: a longitudinal segmentation and a longitudinal classification step. The results show that both steps of the longitudinal pipeline improved the reliability and the accuracy of the discrimination between clinical groups...
May 21, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29784544/classifying-alzheimer-s-disease-with-brain-imaging-and-genetic-data-using-a-neural-network-framework
#13
Kaida Ning, Bo Chen, Fengzhu Sun, Zachary Hobel, Lu Zhao, Will Matloff, Arthur W Toga
A long-standing question is how to best use brain morphometric and genetic data to distinguish Alzheimer's disease (AD) patients from cognitively normal (CN) subjects and to predict those who will progress from mild cognitive impairment (MCI) to AD. Here, we use a neural network (NN) framework on both magnetic resonance imaging-derived quantitative structural brain measures and genetic data to address this question. We tested the effectiveness of NN models in classifying and predicting AD. We further performed a novel analysis of the NN model to gain insight into the most predictive imaging and genetics features and to identify possible interactions between features that affect AD risk...
April 24, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29782316/from-subjective-cognitive-decline-to-alzheimer-s-disease-the-predictive-role-of-neuropsychological-assessment-personality-traits-and-cognitive-reserve-a-7-year-follow-up-study
#14
Valentina Bessi, Salvatore Mazzeo, Sonia Padiglioni, Carolina Piccini, Benedetta Nacmias, Sandro Sorbi, Laura Bracco
The aim of this study was to evaluate the accuracy of neuropsychological assessment in predicting conversion from subjective cognitive decline (SCD) and mild cognitive impairment (MCI) to Alzheimer's disease (AD) and the effect of personality traits and cognitive reserve in progression from SCD to MCI. As part of a longitudinal, clinical-neuropsychological-genetic survey on SCD and MCI, 284 patients referred to our hospital between 1990 and 2017 were included. All patients underwent clinical-extensive neuropsychological evaluation and Apolipoprotein E genotyping; personality traits were assessed in a subgroup...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782314/a-retrospective-belgian-multi-center-mri-biomarker-study-in-alzheimer-s-disease-remember
#15
Ellis Niemantsverdriet, Annemie Ribbens, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Roxanne Bladt, Lene Claes, Peter Paul De Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Jean-Claude Lemper, Eric Mormont, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Dirk Smeets, Hanne Struyfs, Evert Thiery, Jos Tournoy, Eric Triau, Anne-Marie Vanbinst, Jan Versijpt, Maria Bjerke, Sebastiaan Engelborghs
BACKGROUND: Magnetic resonance imaging (MRI) acquisition/processing techniques assess brain volumes to explore neurodegeneration in Alzheimer's disease (AD). OBJECTIVE: We examined the clinical utility of MSmetrix and investigated if automated MRI volumes could discriminate between groups covering the AD continuum and could be used as a predictor for clinical progression. METHODS: The Belgian Dementia Council initiated a retrospective, multi-center study and analyzed whole brain (WB), grey matter (GM), white matter (WM), cerebrospinal fluid (CSF), cortical GM (CGM) volumes, and WM hyperintensities (WMH) using MSmetrix in the AD continuum...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781669/trajectories-of-irregular-word-reading-ability-as-a-proxy-for-premorbid-intelligence-in-alzheimer-s-disease-mild-cognitive-impairment-and-healthy-aging-a-longitudinal-study
#16
Michael Weinborn, Romola S Bucks, Hamid R Sohrabi, Stephanie R Rainey-Smith, Belinda M Brown, Samantha L Gardener, Aleksandra Gozt, Daniel Christensen, Greg Savage, Simon M Laws, Kevin Taddei, Paul Maruff, Joanne S Robertson, Kathryn A Ellis, David Ames, Colin L Masters, Christopher C Rowe, Ralph N Martins
The ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders. However, studies evaluating decline of this skill in Alzheimer's disease (AD) have produced conflicting results. Irregular word reading was assessed three times over 36 months in a large (N = 995) sample, including healthy control, AD, and Mild Cognitive Impairment (MCI) groups. At baseline, MCI and AD groups read correctly an average of 3...
May 21, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29781630/mental-orientation-a-new-approach-to-assessing-patients-across-the-alzheimer-s-disease-spectrum
#17
Gregory Peters-Founshtein, Michael Peer, Yanai Rein, Shlomzion Kahana Merhavi, Zeev Meiner, Shahar Arzy
OBJECTIVE: This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task. METHOD: A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spectrum. A functional MRI study (Experiment 2) in young adults compared activations evoked by the mental-orientation and standard-orientation tasks as well as their overlap with brain regions susceptible to Alzheimer's disease pathology...
May 21, 2018: Neuropsychology
https://www.readbyqxmd.com/read/29780874/the-personalized-alzheimer-s-disease-cortical-thickness-index-predicts-likely-pathology-and-clinical-progression-in-mild-cognitive-impairment
#18
Annie M Racine, Michael Brickhouse, David A Wolk, Bradford C Dickerson
Introduction: An Alzheimer's disease (AD) biomarker adjusted for age-related brain changes should improve specificity for AD-related pathological burden. Methods: We calculated a brain-age-adjusted "personalized AD cortical thickness index" (pADi) in mild cognitive impairment patients from the Alzheimer's Disease Neuroimaging Initiative. We performed receiver operating characteristic analysis for discrimination between patients with and without cerebrospinal fluid evidence of AD and logistic regression in an independent sample to determine if a dichotomized pADi predicted conversion to AD dementia...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780872/neuropsychology-and-neuroimaging-profiles-of-amyloid-positive-versus-amyloid-negative-amnestic-mild-cognitive-impairment-patients
#19
Clémence Tomadesso, Vincent de La Sayette, Robin de Flores, Pierrick Bourgeat, Victor L Villemagne, Stéphanie Egret, Francis Eustache, Gaël Chételat
Introduction: Patients with amnestic mild cognitive impairment (aMCI) are heterogeneous as regard to their amyloid status. The present study aimed at highlighting the neuropsychological, brain atrophy, and hypometabolism profiles of amyloid-positive (Aβpos) versus amyloid-negative (Aβneg) aMCI patients. Methods: Forty-four aMCI patients and 24 Aβneg healthy controls underwent neuropsychological, structural magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780871/computer-based-evaluation-of-alzheimer-s-disease-and-mild-cognitive-impairment-patients-during-a-picture-description-task
#20
Laura Hernández-Domínguez, Sylvie Ratté, Gerardo Sierra-Martínez, Andrés Roche-Bergua
Introduction: We present a methodology to automatically evaluate the performance of patients during picture description tasks. Methods: Transcriptions and audio recordings of the Cookie Theft picture description task were used. With 25 healthy elderly control (HC) samples and an information coverage measure, we automatically generated a population-specific referent. We then assessed 517 transcriptions (257 Alzheimer's disease [AD], 217 HC, and 43 mild cognitively impaired samples) according to their informativeness and pertinence against this referent...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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