keyword
MENU ▼
Read by QxMD icon Read
search

connectome

keyword
https://www.readbyqxmd.com/read/28209314/connection-between-bilateral-temporal-regions-tractography-using-human-connectome-data-and-diffusion-spectrum-imaging
#1
Peng-Hu Wei, Zhi-Qi Mao, Fei Cong, Bo Wang, Zhi-Pei Ling, Shu-Li Liang, Xin-Guang Yu
Temporal lobe epilepsy often propagates inter-hemispherically. Although the pathway of the propagation was verified by electrophysiology, the trajectory remains poorly defined. DTI can depict fiber trajectory but it has limited angular resolution and cannot adequately assess cortical regions. We visualized potential pathways of bitemporal epilepsy propagation using diffusion spectrum imaging (DSI) with data consisting of 8 groups of 514 directions and diffusion templates of 842 subjects from the human connectome project (HCP)...
February 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28182904/neuroscience-needs-behavior-correcting-a-reductionist-bias
#2
REVIEW
John W Krakauer, Asif A Ghazanfar, Alex Gomez-Marin, Malcolm A MacIver, David Poeppel
There are ever more compelling tools available for neuroscience research, ranging from selective genetic targeting to optogenetic circuit control to mapping whole connectomes. These approaches are coupled with a deep-seated, often tacit, belief in the reductionist program for understanding the link between the brain and behavior. The aim of this program is causal explanation through neural manipulations that allow testing of necessity and sufficiency claims. We argue, however, that another equally important approach seeks an alternative form of understanding through careful theoretical and experimental decomposition of behavior...
February 8, 2017: Neuron
https://www.readbyqxmd.com/read/28182017/using-connectome-based-predictive-modeling-to-predict-individual-behavior-from-brain-connectivity
#3
Xilin Shen, Emily S Finn, Dustin Scheinost, Monica D Rosenberg, Marvin M Chun, Xenophon Papademetris, R Todd Constable
Neuroimaging is a fast-developing research area in which anatomical and functional images of human brains are collected using techniques such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and electroencephalography (EEG). Technical advances and large-scale data sets have allowed for the development of models capable of predicting individual differences in traits and behavior using brain connectivity measures derived from neuroimaging data. Here, we present connectome-based predictive modeling (CPM), a data-driven protocol for developing predictive models of brain-behavior relationships from connectivity data using cross-validation...
March 2017: Nature Protocols
https://www.readbyqxmd.com/read/28179163/the-epidemic-spreading-model-and-the-direction-of-information-flow-in-brain-networks
#4
J Meier, X Zhou, A Hillebrand, P Tewarie, C J Stam, P Van Mieghem
The interplay between structural connections and emerging information flow in the human brain remains an open research problem. A recent study observed global patterns of directional information flow in empirical data using the measure of transfer entropy. For higher frequency bands, the overall direction of information flow was from posterior to anterior regions whereas an anterior-to-posterior pattern was observed in lower frequency bands. In this study, we applied a simple Susceptible-Infected-Susceptible (SIS) epidemic spreading model on the human connectome with the aim to reveal the topological properties of the structural network that give rise to these global patterns...
February 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28176164/whole-brain-high-resolution-structural-connectome-inter-subject-validation-and-application-to-the-anatomical-segmentation-of-the-striatum
#5
Pierre Besson, Nicolas Carrière, S Kathleen Bandt, Marc Tommasi, Xavier Leclerc, Philippe Derambure, Renaud Lopes, Louise Tyvaert
The present study describes extraction of high-resolution structural connectome (HRSC) in 99 healthy subjects, acquired and made available by the Human Connectome Project. Single subject connectomes were then registered to the common surface space to allow assessment of inter-individual reproducibility of this novel technique using a leave-one-out approach. The anatomic relevance of the surface-based connectome was examined via a clustering algorithm, which identified anatomic subdivisions within the striatum...
February 7, 2017: Brain Topography
https://www.readbyqxmd.com/read/28174617/parameterizable-consensus-connectomes-from-the-human-connectome-project-the-budapest-reference-connectome-server-v3-0
#6
Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz
Connections of the living human brain, on a macroscopic scale, can be mapped by a diffusion MR imaging based workflow. Since the same anatomic regions can be corresponded between distinct brains, one can compare the presence or the absence of the edges, connecting the very same two anatomic regions, among multiple cortices. Previously, we have constructed the consensus braingraphs on 1015 vertices first in five, then in 96 subjects in the Budapest Reference Connectome Server v1.0 and v2.0, respectively. Here we report the construction of the version 3...
February 2017: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/28174609/disrupted-development-and-imbalanced-function-in-the-global-neuronal-workspace-a-positive-feedback-mechanism-for-the-emergence-of-asd-in-early-infancy
#7
REVIEW
Chris Fields, James F Glazebrook
Autism spectrum disorder (ASD) is increasingly being conceptualized as a spectrum disorder of connectome development. We review evidence suggesting that ASD is characterized by a positive feedback loop that amplifies small functional variations in early-developing sensory-processing pathways into structural and functional imbalances in the global neuronal workspace. Using vision as an example, we discuss how early functional variants in visual processing may be feedback-amplified to produce variant object categories and disrupted top-down expectations, atypically large expectation-to-perception mismatches, problems re-identifying individual people and objects, socially inappropriate, generally aversive emotional responses and disrupted sensory-motor coordination...
February 2017: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/28167349/proportional-thresholding-in-resting-state-fmri-functional-connectivity-networks-and-consequences-for-patient-control-connectome-studies-issues-and-recommendations
#8
Martijn van den Heuvel, Siemon de Lange, Andrew Zalesky, Caio Seguin, Thomas Yeo, Ruben Schmidt
Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or network involves "thresholding" of the connectivity matrix, selecting the set of edges that together form the graph on which network organization is evaluated. To avoid systematic differences in absolute number of edges, studies have argued against the use of an "absolute threshold" in case-control studies and have proposed the use of "proportional thresholding" instead, in which a pre-defined number of strongest connections are selected as network edges, ensuring equal network density across datasets...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28165911/acute-severe-depression-induced-by-stimulation-of-the-right-globus-pallidus-internus
#9
Johanna Philipsson, Rickard L Sjöberg, Jerome Yelnik, Patric Blomstedt
Depressive symptoms may occur after Deep Brain Stimulation (DBS) in the subthalamic nucleus. This is often explained by reduced pharmacological treatment after surgery, and not as a direct effect of DBS. Pallidal DBS seems not to be associated with such side effects and have not, to our knowledge, previously been reported. We present a patient with acute depressive symptoms induced by pallidal DBS. We believe this case strengthen the hypothesis that the basal ganglia and structures involved in the functional connectome of these nucleuses play a role not only in regulation of movement but also in regulation of mood...
February 6, 2017: Neurocase
https://www.readbyqxmd.com/read/28163141/probabilistic-conversion-of-neurosurgical-dbs-electrode-coordinates-into-mni-space
#10
Andreas Horn, Andrea A Kühn, Angela Merkl, Ludy Shih, Ron Alterman, Michael Fox
In neurosurgical literature, findings such as deep brain stimulation (DBS) electrode positions are conventionally reported in relation to the anterior and posterior commissures of the individual patient (AC/PC coordinates). However, the neuroimaging literature including neuroanatomical atlases, activation patterns, and brain connectivity maps has converged on a different population-based standard (MNI coordinates). Ideally, one could relate these two literatures by directly transforming MRIs from neurosurgical patients into MNI space...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28161314/groupwise-structural-parcellation-of-the-whole-cortex-a-logistic-random-effects-model-based-approach
#11
Guillermo Gallardo, William Wells Iii, Rachid Deriche, Demian Wassermann
Current theories hold that brain function is highly related to long-range physical connections through axonal bundles, namely extrinsic connectivity. However, obtaining a groupwise cortical parcellation based on extrinsic connectivity remains challenging. Current parcellation methods are computationally expensive; need tuning of several parameters or rely on ad-hoc constraints. Furthermore, none of these methods present a model for the cortical extrinsic connectivity of the cortex. To tackle these problems, we propose a parsimonious model for the extrinsic connectivity and an efficient parceling technique based on clustering of tractograms...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28161310/statistical-power-and-prediction-accuracy-in-multisite-resting-state-fmri-connectivity
#12
Christian Dansereau, Yassine Benhajali, Celine Risterucci, Emilio Merlo Pich, Pierre Orban, Douglas Arnold, Pierre Bellec
Connectivity studies using resting-state functional magnetic resonance imaging are increasingly pooling data acquired at multiple sites. While this may allow investigators to speed up recruitment or increase sample size, multisite studies also potentially introduce systematic biases in connectivity measures across sites. In this work, we measure the inter-site effect in connectivity and its impact on our ability to detect individual and group differences. Our study was based on real, as opposed to simulated, multisite fMRI datasets collected in N=345 young, healthy subjects across 8 scanning sites with 3T scanners and heterogeneous scanning protocols, drawn from the 1000 functional connectome project...
February 2, 2017: NeuroImage
https://www.readbyqxmd.com/read/28156110/architecture-mapping-of-the-inner-mitochondrial-membrane-proteome-by-chemical-tools-in-live-cells
#13
Song-Yi Lee, Myeong-Gyun Kang, Sanghee Shin, Chulhwan Kwak, Taejoon Kwon, Jeong Kon Seo, Jong-Seo Kim, Hyun-Woo Rhee
The inner mitochondrial membrane (IMM) proteome plays a central role in maintaining mitochondrial physiology and cellular metabolism. Various important biochemical reactions such as oxidative phosphorylation, metabolite production, and mitochondrial biogenesis are conducted by the IMM proteome and mitochondria-targeted therapeutics have been developed for IMM proteins which is deeply related for various human metabolic disease including cancer and neurodegenerative diseases. However, the membrane topology of the IMM proteome remains largely unclear because of the lack of methods to evaluate it in live cells in a high-throughput manner...
February 3, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28154795/connectomic-profile-and-clinical-phenotype-in-newly-diagnosed-glioma-patients
#14
Jolanda Derks, Anne R Dirkson, Philip C de Witt Hamer, Quinten van Geest, Hanneke E Hulst, Frederik Barkhof, Petra J W Pouwels, Jeroen J G Geurts, Jaap C Reijneveld, Linda Douw
Gliomas are primary brain tumors, originating from the glial cells in the brain. In contrast to the more traditional view of glioma as a localized disease, it is becoming clear that global brain functioning is impacted, even with respect to functional communication between brain regions remote from the tumor itself. However, a thorough investigation of glioma-related functional connectomic profiles is lacking. Therefore, we constructed functional brain networks using functional MR scans of 71 glioma patients and 19 matched healthy controls using the automated anatomical labelling (AAL) atlas and interregional Pearson correlation coefficients...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28149942/cognitive-complaints-in-older-adults-at-risk-for-alzheimer-s-disease-are-associated-with-altered-resting-state-networks
#15
Joey A Contreras, Joaquín Goñi, Shannon L Risacher, Enrico Amico, Karmen Yoder, Mario Dzemidzic, John D West, Brenna C McDonald, Martin R Farlow, Olaf Sporns, Andrew J Saykin
INTRODUCTION: Pathophysiological changes that accompany early clinical symptoms in prodromal Alzheimer's disease (AD) may have a disruptive influence on brain networks. We investigated resting-state functional magnetic resonance imaging (rsfMRI), combined with brain connectomics, to assess changes in whole-brain functional connectivity (FC) in relation to neurocognitive variables. METHODS: Participants included 58 older adults who underwent rsfMRI. Individual FC matrices were computed based on a 278-region parcellation...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28148956/micro-connectomics-probing-the-organization-of-neuronal-networks-at-the-cellular-scale
#16
REVIEW
Manuel Schröter, Ole Paulsen, Edward T Bullmore
Defining the organizational principles of neuronal networks at the cellular scale, or micro-connectomics, is a key challenge of modern neuroscience. In this Review, we focus on graph theoretical parameters of micro-connectome topology, often informed by economical principles that conceptually originated with Ramón y Cajal's conservation laws. First, we summarize results from studies in intact small organisms and in samples from larger nervous systems. We then evaluate the evidence for an economical trade-off between biological cost and functional value in the organization of neuronal networks...
February 2, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28146554/fundamental-activity-constraints-lead-to-specific-interpretations-of-the-connectome
#17
Jannis Schuecker, Maximilian Schmidt, Sacha J van Albada, Markus Diesmann, Moritz Helias
The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to experimental observations. Nevertheless, structurally realistic network models of spiking neurons are necessarily underconstrained even if experimental data on brain connectivity are incorporated to the best of our knowledge. Guided by physiological observations, any model must therefore explore the parameter ranges within the uncertainty of the data...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28141820/the-missing-link-predicting-connectomes-from-noisy-and-partially-observed-tract-tracing-data
#18
Max Hinne, Annet Meijers, Rembrandt Bakker, Paul H E Tiesinga, Morten Mørup, Marcel A J van Gerven
Our understanding of the wiring map of the brain, known as the connectome, has increased greatly in the last decade, mostly due to technological advancements in neuroimaging techniques and improvements in computational tools to interpret the vast amount of available data. Despite this, with the exception of the C. elegans roundworm, no definitive connectome has been established for any species. In order to obtain this, tracer studies are particularly appealing, as these have proven highly reliable. The downside of tract tracing is that it is costly to perform, and can only be applied ex vivo...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28140365/multichannel-activity-propagation-across-an-engineered-axon-network
#19
Han-Chiao Isaac Chen, John Wolf, Douglas Smith
OBJECTIVE: Although substantial progress has been made in mapping the connections of the brain, less is known about how this organization translates into brain function. In particular, the massive interconnectivity of the brain has made it difficult to specifically examine data transmission between two nodes of the connectome, a central component of the "neural code." Here, we investigated the propagation of multiple streams of asynchronous neuronal activity across an isolated in vitro "connectome unit...
January 31, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28139694/elevated-temperature-induced-acceleration-of-pact-clearing-process-of-mouse-brain-tissue
#20
Tingting Yu, Yisong Qi, Jingtan Zhu, Jianyi Xu, Hui Gong, Qingming Luo, Dan Zhu
Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a relative simple clearing method based on incubation, which has a great advantage on tissue transparency, fluorescence preservation and immunostaining compatibility for imaging tissue blocks. However, this method suffers from long processing time. Previous studies indicated that increasing temperature can speed up the clearing. In this work, we aim to systematacially and quantitatively study this influence based on PACT with graded increase of temperatures...
January 31, 2017: Scientific Reports
keyword
keyword
10381
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"