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https://www.readbyqxmd.com/read/29475195/instant-messaging-and-nursing-students-clinical-learning-experience
#1
Christoph Pimmer, Florian Brühlmann, Titilayo Dorothy Odetola, Oluwafemi Dipeolu, Urs Gröhbiel, Ademola J Ajuwon
BACKGROUND: Although learning in clinical settings is a key element of nursing education, for many learners these are challenging developmental contexts often marked by isolation and a lack of belongingness. Despite the massive appropriation of mobile instant messaging (MIM) platforms and the connective properties attendant to them, very little is known about their role in and impact on nursing students' clinical learning experiences. APPROACH AND METHODS: To address this gap, the study, which was part of a multinational research project on the use of mobile social media in health professions education in developing countries, examined the use of the instant messaging platform WhatsApp by nursing students during placements and potential associations with socio-professional indicators...
February 10, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29475192/infants-understanding-of-the-definite-indefinite-article-in-a-third-party-communicative-situation
#2
You-Jung Choi, Hyun-Joo Song, Yuyan Luo
The present study examines how infants use their emergent perspective-taking and language comprehension abilities to make sense of interactions between two human agents. In the study, one agent (Agent1) could see only one of two identical balls on an apparatus because of a screen obstructing her view while the infant and another agent (Agent2) could see both balls. 19-month-old English-learning monolingual infants seemed to expect Agent2 to grasp the ball visible to Agent1 when she said to Agent2 "Give me the ball" but not when she said "Give me a ball...
February 20, 2018: Cognition
https://www.readbyqxmd.com/read/29475172/brain-network-alteration-in-patients-with-temporal-lobe-epilepsy-with-cognitive-impairment
#3
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance...
February 20, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29475142/neural-electrical-activity-and-neural-network-growth
#4
F M Gafarov
The development of central and peripheral neural system depends in part on the emergence of the correct functional connectivity in its input and output pathways. Now it is generally accepted that molecular factors guide neurons to establish a primary scaffold that undergoes activity-dependent refinement for building a fully functional circuit. However, a number of experimental results obtained recently shows that the neuronal electrical activity plays an important role in the establishing of initial interneuronal connections...
February 9, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29475076/from-percept-to-concept-in-the-ventral-temporal-lobes-graded-hemispheric-specialisation-based-on-stimulus-and-task
#5
Paul Hoffman, Matthew A Lambon Ralph
The left and right ventral anterior temporal lobes (vATL) have been implicated as key regions for the representation of conceptual knowledge. However, the nature and degree of hemispheric specialisation in their function is unclear. To address this issue, we investigated hemispheric specialisation in the ventral temporal lobes using a distortion-corrected spin-echo fMRI protocol that enhanced signal in vATL. We employed an orthogonal manipulation of stimulus (written words vs pictured objects) and task (naming vs recognition)...
February 2, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29475059/ventro-lateral-motor-thalamus-abnormal-connectivity-in-essential-tremor-before-and-after-thalamotomy-a-resting-state-fmri-study
#6
Constantin Tuleasca, Elena Najdenovska, Jean Régis, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
OBJECTIVE: To evaluate functional connectivity (FC) of the ventro-lateral thalamus, a common target for drug-resistant essential tremor (ET), resting-state data were analyzed before and 1 year after stereotactic radiosurgical thalamotomy (SRS-T), and compared against healthy controls (HC). METHODS: 17 consecutive patients and 10 HC were enrolled. Tremor network was investigated using ventro-lateral ventral (VLV) nucleus as region-of-interest (ROI), extracted using automated segmentation from pretherapeutic diffusion MRI...
February 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29474956/the-clock-gene-period-differentially-regulates-sleep-and-memory-in-drosophila
#7
Robin Fropf, Hong Zhou, Jerry C P Yin
Circadian regulation is a conserved phenomenon across the animal kingdom, and its disruption can have severe behavioral and physiological consequences. Core circadian clock proteins are likewise well conserved from Drosophila to humans. While the molecular clock interactions that regulate circadian rhythms have been extensively described, additional roles for clock genes during complex behaviors are less understood. Here, we show that mutations in the clock gene period result in differential time-of-day effects on acquisition and long-term memory of aversive olfactory conditioning...
February 20, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29474955/title-prior-knowledge-modulates-the-neural-substrates-of-encoding-and-retrieving-naturalistic-events-at-short-and-long-delays
#8
Kyra Bonasia, Melanie J Sekeres, Asaf Gilboa, Cheryl L Grady, Gordon Winocur, Morris Moscovitch
Congruence with prior knowledge and novelty have long been identified as two prominent factors that, despite their opposing characteristics, can both enhance episodic memory. Using narrative film clip stimuli, this study investigated these effects in naturalistic event memories - examining behaviour and neural activation to help explain this paradox. Furthermore, we examined encoding, immediate retrieval, and one-week delayed retrieval to determine how these effects evolve over time. Behaviourally, both congruence with prior knowledge and incongruence/novelty enhanced memory for events, though incongruent events were recalled with more errors over time...
February 20, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29474905/a-non-catalytic-function-of-setd1a-regulates-cyclin-k-and-the-dna-damage-response
#9
Takayuki Hoshii, Paolo Cifani, Zhaohui Feng, Chun-Hao Huang, Richard Koche, Chun-Wei Chen, Christopher D Delaney, Scott W Lowe, Alex Kentsis, Scott A Armstrong
MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutagenesis studies and CRISPR-Cas9 domain screening show the enzymatic SET domain is not necessary for AML cell survival but that a newly identified region termed the "FLOS" (functional location on SETD1A) domain is indispensable. FLOS disruption suppresses DNA damage response genes and induces p53-dependent apoptosis...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29474883/newly-observed-anterior-thalamocortical-fiber-of-the-thalamus-with-7-0t-super-resolution-magnetic-resonance-tractogarphy-and-its-implication-for-the-classical-papez-circuit
#10
Sang-Han Choi, Young-Bo Kim, Zang-Hee Cho
Here, we have employed recently developed super-resolution tractography using 7.0T-MRI to analyze the fine structures involved in thalamocortical connections, something that has proved difficult using conventional techniques. We detail a newly observed thalamocortical pathway connecting the anterior nucleus of the thalamus and the cingulate cortex not via the internal capsule but via the septal area. The observed pathway is believed to be a classical pathway of the Papez circuit but had not been previously identified...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29474873/expression-of-nucleotide-excision-repair-in-alzheimer-s-disease-is-higher-in-brain-tissue-than-in-blood
#11
Helge Leander B Jensen, Meryl S Lillenes, Alberto Rabano, Clara-Cecilie Günther, Tahira Riaz, Shewit T Kalayou, Ingun D Ulstein, Thomas Bøhmer, Tone Tønjum
Age-related changes are increased in patients with Alzheimer's disease (AD), including oxidative stress and DNA damage. We propose that genotoxic stress and DNA repair responses influence neurodegeneration in the pathogenesis of AD. Here, we focus on nucleotide excision repair (NER). Real-time qPCR and mass spectrometry were employed to determine the expression levels of selected NER components. The mRNA levels of the genes encoding the NER proteins RAD23B, RPA1, ERCC1, PCNA and LIG3 as well as the NER-interacting base excision repair protein MPG in blood and brain tissue from four brain regions in patients with AD or mild cognitive impairment and healthy controls (HC), were assessed...
February 20, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29474733/bacmeta-simulator-for-genomic-evolution-in-bacterial-metapopulations
#12
Aleksi Sipola, Pekka Marttinen, Jukka Corander
Summary: The advent of genomic data from densely sampled bacterial populations has created a need for flexible simulators by which models and hypotheses can be efficiently investigated in the light of empirical observations. Bacmeta provides fast stochastic simulation of neutral evolution within a large collection of interconnected bacterial populations with completely adjustable connectivity network. Stochastic events of mutations, recombinations, insertions/deletions, migrations and microepidemics can be simulated in discrete non-overlapping generations with a Wright-Fisher model that operates on explicit sequence data of any desired genome length...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474729/the-science-of-peer-support-as-applied-to-behavioral-medicine-and-the-care-of-individuals-surviving-with-cancer-a-commentary-on-peer-mentors-delivering-a-physical-activity-intervention-for-cancer-survivors-effects-among-mentors-by-pinto-et-al
#13
Christine Rini, Kristi D Graves, Suzanne C O'Neill, Kenneth P Tercyak
There is a critical gap between the resources available to promote health and wellness after cancer and services that address these public health goals. Researchers, policy makers, healthcare providers, and community stakeholders increasingly recognize the benefits of filling this gap with trained peer mentors who can provide health-promotion services to fellow cancer survivors. This commentary addresses a mixed-method study by Pinto and colleagues that investigated the responses and experiences of trained peer mentors who delivered their telephone-based physical activity intervention for breast cancer survivors...
February 21, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29474701/the-direction-of-carbon-and-nitrogen-fluxes-between-ramets-changes-during-ontogeny-under-simulated-competition-for-light
#14
Jana Duchoslavová, Jan Jansa
Resource sharing is universal among connected ramets of clonal plants and is driven both by the developmental status of ramets and resource gradients. Aboveground competition forms spatial light gradients, but the role of resource sharing in such competition is unclear.We examined translocation of resources between mother and daughter ramets of Agrostis stolonifera under light heterogeneity throughout ramet ontogeny. We labelled ramets 13C and 15N to estimate bidirectional translocation of the resources at three developmental stages of daughters...
February 21, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29474564/long-term-outcomes-of-total-correction-for-isolated-total-anomalous-pulmonary-venous-connection-lessons-from-50-years-experience
#15
Takahiko Sakamoto, Mitsugi Nagashima, Kentarou Umezu, Ryogo Houki, Jin Ikarashi, Junko Katagiri, Kenji Yamazaki
OBJECTIVES: Isolated total anomalous pulmonary venous connection (TAPVC) is a relatively rare congenital cardiac defect, while pulmonary venous obstruction (PVO) is associated with poor prognosis. We reviewed the long-term outcome of total correction for isolated TAPVC at our institute and analysed the risk factors for mortality and morbidity. METHODS: A total of 290 isolated TAPVC patients evaluated between 1965 and 2016 were divided into 2 groups: Group Early (n = 151) underwent surgery before 1989; Group Late (n = 139) underwent surgery after 1990...
February 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29474489/insect-tissue-specific-vitellogenin-facilitates-transmission-of-plant-virus
#16
Yan Huo, Yuanling Yu, Liying Chen, Qiong Li, Mengting Zhang, Zhiyu Song, Xiaoying Chen, Rongxiang Fang, Lili Zhang
Insect vitellogenin (Vg) has been considered to be synthesized in the fat body. Here, we found that abundant Vg protein is synthesized in Laodelphax striatellus hemocytes as well. We also determined that only the hemocyte-produced Vg binds to Rice stripe virus (RSV) in vivo. Examination of the subunit composition of L. striatellus Vg (LsVg) revealed that LsVg was processed differently after its expression in different tissues. The LsVg subunit able to bind to RSV exist stably only in hemocytes, while fat body-produced LsVg lacks the RSV-interacting subunit...
February 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29474411/predicting-financial-trouble-using-call-data-on-social-capital-phone-logs-and-financial-trouble
#17
Rishav Raj Agarwal, Chia-Ching Lin, Kuan-Ta Chen, Vivek Kumar Singh
An ability to understand and predict financial wellbeing for individuals is of interest to economists, policy designers, financial institutions, and the individuals themselves. According to the Nilson reports, there were more than 3 billion credit cards in use in 2013, accounting for purchases exceeding US$ 2.2 trillion, and according to the Federal Reserve report, 39% of American households were carrying credit card debt from month to month. Prior literature has connected individual financial wellbeing with social capital...
2018: PloS One
https://www.readbyqxmd.com/read/29474358/technical-feasibility-study-for-production-of-tailored-multielectrode-arrays-and-patterning-of-arranged-neuronal-networks
#18
Matthias Schürmann, Norman Shepheard, Natalie Frese, Kevin Geishendorf, Holger Sudhoff, Armin Gölzhäuser, Ulrich Rückert, Christian Kaltschmidt, Barbara Kaltschmidt, Andy Thomas
In this manuscript, we first reveal a simple ultra violet laser lithographic method to design and produce plain tailored multielectrode arrays. Secondly, we use the same lithographic setup for surface patterning to enable controlled attachment of primary neuronal cells and help neurite guidance. For multielectrode array production, we used flat borosilicate glass directly structured with the laser lithography system. The multi layered electrode system consists of a layer of titanium coated with a layer of di-titanium nitride...
2018: PloS One
https://www.readbyqxmd.com/read/29474352/a-biophysical-model-of-dynamic-balancing-of-excitation-and-inhibition-in-fast-oscillatory-large-scale-networks
#19
Romesh G Abeysuriya, Jonathan Hadida, Stamatios N Sotiropoulos, Saad Jbabdi, Robert Becker, Benjamin A E Hunt, Matthew J Brookes, Mark W Woolrich
Over long timescales, neuronal dynamics can be robust to quite large perturbations, such as changes in white matter connectivity and grey matter structure through processes including learning, aging, development and certain disease processes. One possible explanation is that robust dynamics are facilitated by homeostatic mechanisms that can dynamically rebalance brain networks. In this study, we simulate a cortical brain network using the Wilson-Cowan neural mass model with conduction delays and noise, and use inhibitory synaptic plasticity (ISP) to dynamically achieve a spatially local balance between excitation and inhibition...
February 23, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29474282/online-physician-reviews-in-female-pelvic-medicine-and-reconstructive-surgery-what-do-patients-really-want
#20
Kian Asanad, Pooja S Parameshwar, Justin Houman, Brennan M Spiegel, Timothy J Daskivich, Jennifer T Anger
OBJECTIVES: This study aimed to qualitatively analyze online reviews of Female Pelvic Medicine and Reconstructive Surgery (FPMRS) specialists to better understand patients' experiences and improve patient satisfaction. METHODS: Fifty urologists and urogynecologists were randomly sampled from the Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction membership website. We evaluated patient ratings and reviews of physicians from 4 websites: Yelp, Healthgrades, Vitals, and UCompareHealthCare...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
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