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https://www.readbyqxmd.com/read/28538944/gauging-the-auditory-dimensions-of-dysarthric-impairment-reliability-and-construct-validity-of-the-bogenhausen-dysarthria-scales-bodys
#1
Wolfram Ziegler, Anja Staiger, Theresa Schölderle, Mathias Vogel
Purpose: Standardized clinical assessment of dysarthria is essential for management and research. We present a new, fully standardized dysarthria assessment, the Bogenhausen Dysarthria Scales (BoDyS). The measurement model of the BoDyS is based on auditory evaluations of connected speech using 9 scales (traits) assessed by 4 elicitation methods. Analyses of the BoDyS' reliability and construct validity were performed to test this model, with the aim of gauging the auditory dimensions of speech impairment in dysarthria...
May 23, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28538820/communication-resources-of-managers-and-business-professionals
#2
Clarissa Araujo Pedrotti, Mara Behlau
Purpose: To analyze the communication resources reported by managers in the business environment and compare the resources used to those reported by business professionals. Methods: 82 professionals volunteered to participate in the research, divided into 50 managers (MP) and 32 business professionals (BP) from industry section in Caxias do Sul and the surrounding region (Brazil). A questionnaire with 4 topics was used: personal data, self-assessment of communicative behavior, self-assessment of communicative resources, and selection of positive and negative resources influencing communication...
May 22, 2017: CoDAS
https://www.readbyqxmd.com/read/28538739/multiplex-pcr-method-for-minion-and-illumina-sequencing-of-zika-and-other-virus-genomes-directly-from-clinical-samples
#3
Joshua Quick, Nathan D Grubaugh, Steven T Pullan, Ingra M Claro, Andrew D Smith, Karthik Gangavarapu, Glenn Oliveira, Refugio Robles-Sikisaka, Thomas F Rogers, Nathan A Beutler, Dennis R Burton, Lia Laura Lewis-Ximenez, Jaqueline Goes de Jesus, Marta Giovanetti, Sarah C Hill, Allison Black, Trevor Bedford, Miles W Carroll, Marcio Nunes, Luiz Carlos Alcantara, Ester C Sabino, Sally A Baylis, Nuno R Faria, Matthew Loose, Jared T Simpson, Oliver G Pybus, Kristian G Andersen, Nicholas J Loman
Genome sequencing has become a powerful tool for studying emerging infectious diseases; however, genome sequencing directly from clinical samples (i.e., without isolation and culture) remains challenging for viruses such as Zika, for which metagenomic sequencing methods may generate insufficient numbers of viral reads. Here we present a protocol for generating coding-sequence-complete genomes, comprising an online primer design tool, a novel multiplex PCR enrichment protocol, optimized library preparation methods for the portable MinION sequencer (Oxford Nanopore Technologies) and the Illumina range of instruments, and a bioinformatics pipeline for generating consensus sequences...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28538719/inter-city-connections
#4
(no author information available yet)
No abstract text is available yet for this article.
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28538709/minimal-invasive-cystometry-and-intra-abdominal-pressure-assessments-in-rodents-a-novel-animal-study
#5
Yafei Yang, Jin Yang, Lin Chen, Jianyun Hu, Shasha Xing, Bastian Amend, Arnulf Stenzl, Xin Wei, Haifeng Hu
BACKGROUND The abdominal straining pattern can act as a novel parameter for improving the prediction of bladder outlet obstruction (BOO). To preserve detrusor function in the early stage of urinary system impairment, such as BOO, we establish a novel method for cystometry and Intra-abdominal pressure (IAP) assessments in rodents without cystostomy. MATERIAL AND METHODS Twenty mice and rats were divided into three groups (control, sham-operated and BOO group) respectively. The cystometry and IAP assessments were measured by the pediatric venous indwelling sheath and coronary dilatation catheter connected to Laborie urodynamic system on postoperative day 7...
May 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28538701/chlorpromazine-increases-the-expression-of-polysialic-acid-polysia-in-human-neuroblastoma-cells-and-mouse-prefrontal-cortex
#6
Chikara Abe, Saki Nishimura, Airi Mori, Yuki Niimi, Yi Yang, Masaya Hane, Ken Kitajima, Chihiro Sato
The neural cell adhesion molecule (NCAM) is modified by polysialic acid (polySia or PSA) in embryonic brains. In adult brains, polySia modification of NCAM is only observed in restricted areas where neural plasticity, remodeling of neural connections, or neural generation is ongoing although the amount of NCAM remains unchanged. Impairments of the polySia-expression and several single nucleotide polymorphisms (SNPs) of the polysialyltransferase (polyST) ST8SIA2 gene are reported to be associated with schizophrenia and bipolar disorder...
May 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28538669/the-peroxisome-mitochondria-connection-how-and-why
#7
REVIEW
Marc Fransen, Celien Lismont, Paul Walton
Over the past decades, peroxisomes have emerged as key regulators in overall cellular lipid and reactive oxygen species metabolism. In mammals, these organelles have also been recognized as important hubs in redox-, lipid-, inflammatory-, and innate immune-signaling networks. To exert these activities, peroxisomes must interact both functionally and physically with other cell organelles. This review provides a comprehensive look of what is currently known about the interconnectivity between peroxisomes and mitochondria within mammalian cells...
May 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28538653/development-of-diamond-and-silicon-mems-sensor-arrays-with-integrated-readout-for-vapor-detection
#8
Maira Possas-Abreu, Farbod Ghassemi, Lionel Rousseau, Emmanuel Scorsone, Emilie Descours, Gaelle Lissorgues
This paper reports on the development of an autonomous instrument based on an array of eight resonant microcantilevers for vapor detection. The fabricated sensors are label-free devices, allowing chemical and biological functionalization. In this work, sensors based on an array of silicon and synthetic diamond microcantilevers are sensitized with polymeric films for the detection of analytes. The main advantage of the proposed system is that sensors can be easily changed for another application or for cleaning since the developed gas cell presents removable electrical connections...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28538571/angiosome-based-allografts-vascularized-composite-allotransplantation-for-tailored-subunit-reconstruction-with-volkmann-ischemic-contracture-as-a-case-in-point
#9
G Ian Taylor, David S Sparks, Adam C Gascoigne, Russell J Corlett, Mark W Ashton
BACKGROUND: As we enter an age with new approaches to tissue reconstruction, the emphasis on the adage "like for like" has become even more relevant. This study illustrates the potential for several tailored vascularized composite allotransplantation reconstructive techniques and, in particular, for the management of Volkmann contracture. METHODS: Twenty fresh cadaver dissections and 30 archival lead oxide radiographic studies were examined to (1) identify potential upper limb vascularized composite allotransplantation donor sites (i...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538520/radiation-induced-cerebellar-cerebral-functional-connectivity-alterations-in-nasopharyngeal-carcinoma-patients
#10
Qiongmin Ma, Ling-Li Zeng, Jian Qin, Zhiguo Luo, Jianpo Su, Donglin Wu, Shijun Qiu, Dewen Hu
The current study aimed to investigate the altered cerebellar-cerebral functional connectivity (FC) induced by radiotherapy to nasopharyngeal carcinoma (NPC) patients. Twenty-four NPC patients without treatment, and 35 NPC patients receiving radiotherapy underwent functional MRI scanning. Montreal cognitive assessment (MoCA) was performed to evaluate the cognitive status of all participants. FC between 10 predefined cerebellar seeds, which were demonstrated to be involved in different brain functional networks, and all brain voxels was obtained for each participant...
May 19, 2017: Neuroreport
https://www.readbyqxmd.com/read/28538516/left-lateralization-of-resting-state-functional-connectivity-between-the-presupplementary-motor-area-and-primary-language-areas
#11
William Lou, Kyung K Peck, Nicole Brennan, Arka Mallela, Andrei Holodny
An abundance of evidence points to the role of a presupplementary motor area (pre-SMA) in human language. This study explores the pre-SMA resting state connectivity network and the nature of its connections to known language areas. We tested the hypothesis that by seeding the pre-SMA, one would be able to establish language laterality to known cortical and subcortical language areas. We analyzed data from 30 right-handed healthy controls and performed the resting state functional MRI. A seed-based analysis using a manually drawn pre-SMA region of interest template was applied...
May 19, 2017: Neuroreport
https://www.readbyqxmd.com/read/28538483/connecting-police-violence-with-reproductive-health
#12
John C Weed
No abstract text is available yet for this article.
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28538420/prediction-of-the-outcome-of-bladder-dysfunction-based-on-electrically-induced-reflex-findings-in-patients-with-cauda-equina-syndrome-a-retrospective-study
#13
Dong Gyu Lee, Sang Gyu Kwak, Min Cheol Chang
The evaluation of the electrically induced bulbocavernosus reflex (BCR) using electromyography (EMG) is a useful tool for evaluating the integrity of sacral spinal segments 2 to 4, and that of their afferent and efferent connections in the urogenital region. In the current retrospective study, the value of this technique in predicting the outcome of bladder dysfunction was investigated in patients with cauda equina syndrome (CES). Electrically induced BCR (E-BCR) was evaluated in 40 patients with bladder dysfunction due to CES at the subacute stage (7-90 days)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538231/informal-peer-assisted-learning-groups-did-not-lead-to-better-performance-of-saudi-dental-students
#14
Maha AbdelSalam, Maha El Tantawi, Asim Al-Ansari, Adel AlAgl, Fahad Al-Harbi
OBJECTIVES: To describe peer-assisted learning (PAL) groups formed by dental undergraduate students in a biomedical course and investigate the association of individual and group characteristics with academic performance. SUBJECTS AND METHODS: In 2015, 92 4th yr. students (males: 43; females: 49) in the College of Dentistry, University of Dammam, Saudi Arabia were invited to form PAL groups to study a unit in a biomedical course. An examination was used to assess their knowledge after two weeks...
May 23, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28538225/pavlov-s-reflex-before-pavlov-early-accounts-from-the-english-french-and-german-classic-literature
#15
Sven Jarius, Brigitte Wildemann
The concept of classical conditioning (CC), strongly connected with the name and work of the Russian physiologist Ivan Petrovich Pavlov (1849-1936), has become the foundation of the modern science of learning and, in particular, of the influential theories of Watson and Skinner and the entire school of behaviourism. In this paper, we give a number of forgotten accounts of CC in the English, French, and German classic literature that pre-date Pavlov's reports by decades or even centuries. These instances are taken from works of the 16th, 18th, and 19th centuries - authored by some of the finest writers of England (Sterne, Locke), France (Rabelais), and Germany (Jean Paul) - and indicate that the psychological mechanisms now described as CC were known long before Pavlov and his successors elaborated on them in a systematic way...
May 25, 2017: European Neurology
https://www.readbyqxmd.com/read/28538224/transcortical-sensory-aphasia-after-left-frontal-lobe-infarction-loss-of-functional-connectivity
#16
Miseon Kwon, Woo Hyun Shim, Sang-Joon Kim, Jong S Kim
BACKGROUND: The underlying mechanism of transcortical sensory aphasia (TSA) caused by lesions occurring in the left frontal lobe remains unclear. We attempted to investigate the mechanism with the use of functional MRI (fMRI). METHODS: We studied 2 patients with TSA after a left frontal infarction identified by diffusion-weighted MRI. As control subjects, a patient with transcortical motor aphasia and a healthy normal adult were chosen. The Korean version of Western Aphasia Battery was performed initially and at 3 months post stroke...
May 25, 2017: European Neurology
https://www.readbyqxmd.com/read/28537945/making-sense-of-effective-partnerships-among-senior-leaders-in-the-national-health-service
#17
Mahima Mitra, Timothy Hoff, Paul Brankin, Sue Dopson
BACKGROUND: Changing health care systems depend on strong organizational leadership that realizes the collaborative potential of both physician and nonphysician leaders. PURPOSE: The aim of this study was to seek insight into the everyday health care leader experience by examining 24 physician and nonphysician leaders working in the U.K. National Health Service. We explored (a) how they make sense of and act with respect to specific collaborative tensions in their interactions and (b) which aspects of their everyday leadership contexts heighten the probability for producing and resolving such tensions...
May 22, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28537852/-i-felt-like-i-was-being-abused-all-over-again-how-survivors-of-child-sexual-abuse-make-sense-of-the-perinatal-period-through-their-narratives
#18
Jane Byrne, Cordet Smart, Gilli Watson
Sequelae following child sexual abuse pervade the lives of adult survivors, significantly impacting on pregnancy and childbirth. Symptoms of this distress are recognized, but meanings for women are less understood. This research aimed to examine the meaning for women themselves of the impact of child sexual abuse on experiences of pregnancy, childbirth, and the postnatal period. Taking a critical feminist perspective, three open-ended interviews with three survivors enabled women's narratives of pregnancy and childbirth to be heard, explored the structure of these narratives, including how experiences were connected, and identified key themes and how selves and others were positioned...
May 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28537786/designing-a-community-based-population-health-model
#19
Christopher J Durovich, Peter W Roberts
The pace of change from volume-based to value-based payment in health care varies dramatically among markets. Regardless of the ultimate disposition of the Affordable Care Act, employers and public-private payers will continue to increase pressure on health care providers to assume financial risk for populations in the form of shared savings, bundled payments, downside risk, or even capitation. This article outlines a suggested road map and practical considerations for health systems that are building or planning to build population health capabilities to meet the needs of their local markets...
May 24, 2017: Population Health Management
https://www.readbyqxmd.com/read/28537719/synthesis-and-characterization-of-the-lithium-rich-phosphidosilicates-li10si2p6-and-li3si3p7
#20
Henrik Eickhoff, Lorenzo Toffoletti, Wilhelm Klein, Gabriele Raudaschl-Sieber, Thomas F Fässler
The lithium phosphidosilicates Li10Si2P6 and Li3Si3P7 are obtained by high-temperature reactions of the elements or including binary Li-P precursors. Li10Si2P6 (P21/n, Z = 2, a = 7.2051(4) Å, b = 6.5808(4) Å, c = 11.6405(7) Å, β = 90.580(4)°) features edge-sharing SiP4 double tetrahedra forming [Si2P6](10-) units with a crystal structure isotypic to Na10Si2P6 and Na10Ge2P6. Li3Si3P7 (P21/m, Z = 2, a = 6.3356(4) Å, b = 7.2198(4) Å, c = 10.6176(6) Å, β = 102.941(6)°) crystallizes in a new structure type, wherein SiP4 tetrahedra are linked via common vertices and which are further connected by polyphosphide chains to form unique ∞(2)[Si3P7](3-) double layers...
May 24, 2017: Inorganic Chemistry
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