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Preeclampsia

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https://www.readbyqxmd.com/read/28923940/defective-decidualization-during-and-after-severe-preeclampsia-reveals-a-possible-maternal-contribution-to-the-etiology
#1
Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quiñonero, Patricia Diaz-Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla-Iserte, Michael McMaster, Olga Genbacev, Alfredo Perales, Susan J Fisher, Carlos Simón
In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with control cells, they failed to decidualize in vitro as demonstrated by morphological criteria and the analysis of stage-specific antigens (i...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923887/author-response-long-term-cerebral-white-and-gray-matter-changes-after-preeclampsia
#2
Timo Siepmann, Henry Boardman, Amy Bilderbeck, Ludovica Griffanti, Yvonne Kenworthy, Charlotte Zwager, David McKean, Jane Francis, Stefan Neubauer, Grace Z Yu, Adam J Lewandowski, Yrsa Bergmann Sverrisdottir, Paul Leeson
No abstract text is available yet for this article.
September 19, 2017: Neurology
https://www.readbyqxmd.com/read/28923886/letter-re-long-term-cerebral-white-and-gray-matter-changes-after-preeclampsia
#3
Antonio Culebras
No abstract text is available yet for this article.
September 19, 2017: Neurology
https://www.readbyqxmd.com/read/28923490/the-association-of-maternal-asthma-and-early-pregnancy-vitamin-d-with-risk-of-preeclampsia-an-observation-from-vitamin-d-antenatal-asthma-reduction-trial-vdaart
#4
Hooman Mirzakhani, Vincent J Carey, Thomas F McElrath, Nancy Laranjo, George O'Connor, Ronald E Iverson, Aviva Lee-Parritz, Robert C Strunk, Leonard B Bacharier, George A Macones, Robert S Zeiger, Michael Schatz, Bruce W Hollis, Augusto A Litonjua, Scott T Weiss
BACKGROUND: Maternal asthma, uncontrolled asthma, and low vitamin D levels during pregnancy have been individually linked to increased risk of preeclampsia. OBJECTIVE: To investigate the association of history of physician-diagnosed asthma and uncontrolled asthma status during pregnancy with the risk of preeclampsia and the effects of early pregnancy vitamin D concentrations on this relationship. METHODS: A total of 816 subjects with available pregnancy outcome data and risk factors of interest were analyzed...
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28921730/comparison-of-the-percentages-of-cd4-%C3%A2-cd25-high-%C3%A2-foxp3-cd4-%C3%A2-cd25-low-%C3%A2-foxp3-and-cd4-%C3%A2-foxp3-tregs-in-the-umbilical-cord-blood-of-babies-born-to-mothers-with-and-without-preeclampsia
#5
Farha El-Chennawi, Ibrahim Mohamed Rageh, Amira Ibrahim Mansour, Mohammed Ibrahim Darwish, Ashraf Antar Elghzaly, Basma El Sayed Sakr, Khaled Mohsen Elbaz
PROBLEM: Little is known about how preeclampsia affects regulatory T-cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4(+)  CD25(high)  FOXP3(+) , CD4(+)  CD25(low)  FOXP3(+) , and CD4(+)  FOXP3(+) Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. METHOD OF STUDY: The percentage of umbilical cord blood CD4(+)  CD25(high)  FOXP3(+) , CD4(+)  CD25(low)  FOXP3(+) , and CD4(+)  FOXP3(+) Tregs were analyzed by flow cytometry...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28921728/undifferentiated-connective-tissue-diseases-and-adverse-pregnancy-outcomes-an-undervalued-association
#6
REVIEW
Arsenio Spinillo, Fausta Beneventi, Roberto Caporali, Veronique Ramoni, Carlomaurizio Montecucco
Undifferentiated connective tissue diseases (UCTDs) are a heterogeneous group of disorders characterized by symptoms and signs suggestive of systemic autoimmune rheumatic disease (ARD), but which do not fulfill all the established criteria for definite diagnosis of a condition. Although a third of UCTDs can progress to a definite ARD within months or years, most UCTDs can remain stable for years with minimal disease activity. The annual incidence of UCTD in the general population ranges from 14 to 140 per 100 000 people...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28920713/estradiol-decreases-blood-pressure-in-association-with-redox-regulation-in-preeclampsia
#7
Goran M Babic, Snezana D Markovic, Mirjana Varjacic, Natasa Z Djordjevic, Tamara Nikolic, Isidora Stojic, Vladimir Jakovljevic
In this study, we tested a hypothesis that a short-term estradiol therapy may reduce blood pressure in preeclampsia by modulating plasma oxidative stress. The intramuscular injections of 10 mg 17-beta-estradiol were prescribed to preeclamptic pregnant women during the 3-day therapy before a labor induction. The analyses of mean arterial pressure (MAP), serum estradiol concentrations, plasma superoxide anion (O2.), hydrogen peroxide (H2O2), nitrites (NO2(-)), and peroxynitrite (ONOO(-)) were conducted before and during the therapy...
September 18, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28919605/current-trend-of-using-anti-hypertensives-in-pregnancy-and-postpartum-period-in-a-tertiary-level-hospital
#8
M Sultana, S K Saha, A K Sarker, S Khatun, M M Sarker, T Sultana, F Noor, M M Faysal
Hypertensive disorders are one of the most common disorders in pregnancy. They are amongst the major cause of maternal and perinatal morbidity and mortality. Incidence is increasing in developing countries like Bangladesh. This cross sectional descriptive study has done to observe the utilization of antihypertensive drugs in hypertensive disorders of pregnancy and conducted from January 2016 to December 2016 in the department of Pharmacology in collaboration with department of Gynecology and Obstetrics in Mymensingh Medical College Hospital, Mymensingh, Bangladesh...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28919298/mxra5-is-decreased-in-preeclampsia-and-affects-trophoblast-cell-invasion-through-the-mapk-pathway
#9
Lan Ding, Shaocong Li, Yanshang Zhang, Junfeng Gai, Jianfang Kou
Preeclampsia causes gestational failure in a significant number of women annually. Insufficient trophoblast cell invasion plays an essential role in preeclampsia pathogenesis. Matrix-remodeling associated 5 (MXRA5) is a proteoglycan involved in adhesion and matrix remodeling. This study sought to explore the role of MXRA5 in trophoblast cell invasion. Preeclamptic villi were obtained for the delineation of MXRA5 expression. Specific MXRA5 siRNA and pcDNA3.1/MXRA5 were used to manipulate MXRA5 expression in HTR-8/SVneo...
September 14, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28918595/successful-pregnancy-in-a-ckd-patient-on-a-low-protein-supplemented-diet-an-opportunity-to-reflect-on-ckd-and-pregnancy-in-mexico-an-emerging-country
#10
Julia Nava, Silvia Moran, Veronica Figueroa, Adriana Salinas, Margy Lopez, Rocio Urbina, Abril Gutierrez, Jose Luis Lujan, Alejandra Orozco, Rafael Montufar, Giorgina B Piccoli
Pregnancy is probably the most important challenge in young women with chronic kidney disease (CKD). The challenge is greater in developing countries, in which access to dialysis is uneven, and prenatal care for CKD patients is not uniformly available. This case report summarizes some of the challenges faced by pregnant CKD women in a developing country. A 35-year-old woman, affected by an undiagnosed kidney disease, experienced preeclampsia at 24 years of age, and started dialysis in emergency at age 31 in the context of severe preeclampsia in her second pregnancy...
September 16, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#11
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. STUDY DESIGN: Secondary analysis of a prospective cohort of 18-40 year old women with 1-2 prior pregnancy losses (n=1193) participating in a multi-center randomized, placebo-controlled trial of low-dose aspirin...
September 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28915802/determinants-of-pre-eclampsia-eclampsia-among-women-attending-delivery-services-in-selected-public-hospitals-of-addis-ababa-ethiopia-a-case-control-study
#12
Teklit Grum, Abiy Seifu, Mebrahtu Abay, Teklit Angesom, Lidiya Tsegay
BACKGROUND: Pre-eclampsia is a pregnancy-specific hypertensive disorder usually occurs after 20 weeks of gestation. It is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. In Ethiopia, the major direct obstetric complications including pre-eclampsia/eclampsia account for 85% of the maternal deaths. Unlike deaths due to other direct causes, pre-eclampsia/ eclampsia related deaths appear to be increasing and linked to multiple factors, making prevention of the disease a continuous challenge...
September 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28915528/-antenatal-steroid-therapy-in-threatened-premature-birth-state-of-the-art
#13
Dimitra Stavropoulou, Roland Hentschel
The aim of this work is to provide an overview of the recommendations in the current literature for the induction of lung maturation therapy. In particular, special attention is focused on specific situations, such as chorioamnionitis, intrauterine growth retardation and preeclampsia, which often lead to premature birth. Additionally, some aspects of antenatal steroid therapy, despite its widespread use, still require clarification. Among them is the repetitive administration of steroid therapy. On the basis of the Cochrane analysis of 2015, advantages and disadvantages for children and pregnant women are explained...
September 15, 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28915449/increased-expression-of-nlrp3-inflammasome-in-placentas-from-pregnant-women-with-severe-preeclampsia
#14
Ingrid C Weel, Mariana Romão-Veiga, Mariana L Matias, Eduardo G Fioratti, Jose C Peraçoli, Vera T Borges, João P Araujo, Maria T Peraçoli
Preeclampsia is a pregnancy disorder characterized by imbalance between pro- and anti-inflammatory cytokines associated with high plasma levels of uric acid and Interleukin-1 beta (IL-1β). The inflammasome is a protein complex that mediates innate immune responses via caspase-1 activation promoting secretion of IL-1β and IL-18 in their active forms, and also release of the high-mobility group box 1 protein (HMGB1). As the placenta seems to play an important role in the pathogenesis of PE, the present study investigated the expression of genes and proteins related to the inflammasome in placentas from pregnant women with severe preeclampsia...
September 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28915160/current-insights-in-obstetric-antiphospholipid-syndrome
#15
Karen Schreiber, Massimo Radin, Savino Sciascia
PURPOSE OF REVIEW: Antiphospholipid syndrome (APS) is defined as the association of thrombotic events and/or obstetric morbidity in patients persistently positive for antiphospholipid antibodies (aPL). In this review, we will highlight the most important clinical presentations of APS with a focus on the obstetric morbidity, the current management strategies and the outlook for the future. RECENT FINDINGS: The use of aspirin and heparin has improved the pregnancy outcome in obstetric APS and approximately 70% of pregnant women with APS have a successful pregnancy outcome...
September 14, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28914979/systemic-evaluation-of-vascular-dysfunction-by-high-resolution-sonography-in-an-n%C3%AF-nitro-l-arginine-methyl-ester-hydrochloride-induced-mouse-model-of-preeclampsia-like-symptoms
#16
Ying Zhao, Ning Yang, Hanying Li, Wei Cai, Xin Zhang, Yongqiang Ma, Xiulong Niu, Guohong Yang, Xin Zhou, Yuming Li
OBJECTIVES: The purpose of this study was to evaluate vascular function, including arterial resistance and endothelial function, by high-resolution sonography in an Nω -nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced mouse model of preeclampsia-like symptoms. METHODS: Pregnant mice were subcutaneously injected with a saline solution (control; n = 10) or l-NAME (n = 10) between the 7th and 18th days of gestation. The resistive index and pulsatility index (RI and PI, indicators of arterial resistance) of the uteroplacental, umbilical, femoral, and common carotid arteries and the flow-mediated dilatation (index of endothelial function) of the femoral artery were measured by high-frequency sonography in both groups...
September 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28913144/effect-of-pigtail-catheter-application-on-obstetric-outcomes-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-pregnancies-following-hyperstimulation-syndrome
#17
Pınar Çağlar Aytaç, Hakan Kalaycı, Selçuk Yetkinel, Didem Alkaş, Seda Yüksel Şimşek, Bülent Haydardedeoğlu, Esra Bulgan Kılıçdağ
OBJECTIVE: To evaluate the effects of percutaneous pigtail catheter drainage on the outcomes of intracytoplasmic sperm injection (ICSI) pregnancies following moderate or severe ovarian hyperstimulation syndrome (OHSS). MATERIALS AND METHODS: This retrospective study included 189 patients hospitalized for OHSS following ICSI treatment in a tertiary in vitro fertilization unit between 2006 and 2014. Pigtail catheters were applied in 63 patients; the other 126 patients did not need that treatment...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28913132/the-incidence-risk-factors-and-mortality-of-preterm-neonates-a-prospective-study-from-jordan-2012-2013
#18
Nadin M Abdel Razeq, Yousef S Khader, Anwar M Batieha
OBJECTIVE: To explore the incidence of preterm delivery, maternal risk factors for having a preterm neonate, and preterm neonates' mortality in Jordan. MATERIALS AND METHODS: A cross-sectional population-based design was applied. Socio-demographic, perinatal, delivery risk factors, and survival information were gathered in pre- and post-hospital discharge interviews with 21075 women who gave birth to live neonates at ≥20 weeks of gestation in 18 hospitals in Jordan...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28913131/the-significance-of-reverse-flow-in-ductus-venosus-between-sixteen-and-twenty-weeks-gestation
#19
Gökhan Karakoç, And Yavuz, Serenat Eriş Yalçın, Mehmet Özgür Akkurt, Nuri Danışman
OBJECTIVE: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks' gestation and trisomy 21 and adverse perinatal outcomes. MATERIALS AND METHODS: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus venosus Doppler (DVD) measurements were obtained throughout the 6-month period from women who underwent amniocentesis procedures due to increased risk for trisomy 21 in terms of first or second trimester screening test results...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912817/the-effects-of-vitamin-d-supplement-on-prevention-of-recurrence-of-preeclampsia-in-pregnant-women-with-a-history-of-preeclampsia
#20
Sanam Behjat Sasan, Farnaz Zandvakili, Nasrin Soufizadeh, Elaheh Baybordi
INTRODUCTION: Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. METHOD AND MATERIALS: The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks...
2017: Obstetrics and Gynecology International
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