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Preeclampsia

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https://www.readbyqxmd.com/read/29353343/the-decreased-expression-of-stat3-and-p-stat3-in-preeclampsia-like-rat-placenta
#1
Zhan Zhang, Xiaofang Wang, Jinming Wang, Linlin Zhang
This study aims to investigate the expression of Stat3 and p-Stat3 in the placenta of a preeclampsia-like rat model induced by Nωnitro-L-arginine methyl ester (L-NAME). Two-to three-month-old (20 males, 40 females) Sprague-Dawley rats were used in this study. After conception was confirmed by vaginal smears, on the thirteenth day of pregnancy, the animals were allocated into two groups: control (0.9% NaCl administered) group and L-NAME (75 mg/kg) group. After the treatment of L-NAME, there was a significant increase in systolic blood pressure (SBP) levels in the L-NAME group (148...
January 20, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29349936/preeclampsia-increases-the-incidence-of-postpartum-cerebrovascular-disease-in-korean-population
#2
Yejin Park, Geum Joon Cho, Log Young Kim, Tae Seon Lee, Min Jeong Oh, Young Han Kim
BACKGROUND: Multiple studies have been reported regarding preeclampsia as a possible risk factor of cerebrovascular disease (CVD). However, the correlation of preeclampsia and CVD, whether it is a cause-effect relationship or they are sharing common predisposing condition, is not well understood. Therefore, the aim of this study was to investigate the association between the preeclampsia during pregnancy and development of postpartum CVD. METHODS: A total of 1,384,550 Korean women who had a delivery between January 1, 2010 and December 31, 2012, were enrolled...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29348884/alpha-1-antitrypsin-functions-as-a-protective-factor-in-preeclampsia-through-activating-smad2-and-inhibitor-of-dna-binding-4
#3
Yaling Feng, Nan Wang, Jianjuan Xu, Jinfang Zou, Xi Liang, Huan Liu, Ying Chen
Pre-eclampsia (PE) is one of the most common reason for high morbidity and mortality of maternal and prenatal infants. Production from oxidative stress results in maternal ROS system and anti-oxidation defense system imbalance to promote tissue ischemia and hypoxia, and ultimately impairs the maternal organs and placenta. Our previous study showed that exogenous Alpha-1-antitrypsin (AAT) and overexpression of AAT in umbilical vein cell (HUVEC) hypoxia-reoxygenation model could increase the activity of antioxidant enzymes, and played a protective role in preeclampsia animal model...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29347927/prevalence-of-hypertensive-disorders-of-pregnancy-in-ethiopia-a-systemic-review-and-meta-analysis
#4
Abadi Kidanemariam Berhe, Getachew Mullu Kassa, Gedefaw Abeje Fekadu, Achenef Asmamaw Muche
BACKGROUND: Although hypertensive disorders of pregnancy are the leading cause of poor perinatal outcomes in Ethiopia, there is no study that shows the national prevalence. Therefore, the aim of this study was to estimate the national pooled prevalence of hypertensive disorders of pregnancy from studies conducted in different parts of the country. METHODS: Databases; MEDLINE, PubMed, HINARI, EMBASE, Google Scholar and African Journals Online were searched by using different search terms on HDP and Ethiopia...
January 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29344946/preeclampsia-and-scleroderma-a-prospective-nation-wide-analysis
#5
Mads Kamper-Jørgensen, Hilary S Gammill, J Lee Nelson
In a preliminary case-control study, women with scleroderma more frequently reported having had hypertensive complications during pregnancy compared with healthy women. To prospectively investigate this possible association, we conducted a nation-wide cohort analysis of a major hypertensive complication during pregnancy, namely preeclampsia, and later scleroderma. Analyses were based on Danish register-based birth and hospital contact data on preeclampsia and scleroderma. We followed 778,758 women from time of giving birth between 1978 and 2010 to end of follow-up, emigration, death, or scleroderma diagnosis, whichever occurred first...
January 18, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29341340/bias-from-restricting-to-live-births-when-estimating-effects-of-prescription-drug-use-on-pregnancy-complications-a-simulation
#6
Elizabeth A Suarez, Suzanne N Landi, Mitchell C Conover, Michele Jonsson Funk
PURPOSE: Administrative claim databases are increasingly being used to study the safety of medication exposures during pregnancy. These studies are restricted to live births due to a reliance on algorithms for estimating gestational age that are based on codes associated with live delivery. Conditioning on live birth may induce selection bias when studying the effect of a drug on a pregnancy complication if fetal death is a competing risk for the complication or is caused by the complication...
January 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29340329/a-salivary-urea-nitrogen-dipstick-to-detect%C3%A2-obstetric-related-acute-kidney-disease-in-malawi
#7
Rhys D R Evans, William Cooke, Ulla Hemmila, Viviane Calice-Silva, Jochen Raimann, Alison Craik, Chimwemwe Mandula, Priscilla Mvula, Ausbert Msusa, Gavin Dreyer, Nathan W Levin, Roberto Pecoits-Filho
Introduction: Obstetric-related acute kidney injury (AKI) is associated with adverse outcomes for mother and fetus, particularly in low-income countries. However, laboratory-independent tools to facilitate diagnosis are lacking. We assessed the diagnostic performance of a salivary urea nitrogen (SUN) dipstick to detect obstetric-related acute kidney disease in Malawi. Methods: Women at high risk for AKI admitted to an obstetric unit in Blantyre, Malawi, were recruited between 21 September and 11 December 2015...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29334762/altered-redox-state-modulates-endothelial-kca2-3-and-kca3-1-levels-in-normal-pregnancy-and-preeclampsia
#8
Shinkyu Choi, Ji Aee Kim, Hai-Yan Li, Sae-Jin Lee, Ye Seon Seok, Tae Hun Kim, Ki-Hwan Han, Mi Hye Park, Geum Joon Cho, Suk Hyo Suh
AIMS: Altered redox state has been related to the development of normal pregnancy (NP) and preeclampsia (PE). Endothelial KCa2.3 and KCa3.1 (KCas) play an important role in vasodilation, and KCas levels are affected by oxidative stress. We investigated the mechanisms of oxidative stress-mediated KCas expression modulation during NP and PE. RESULTS: Human uterine microvascular endothelial cells were incubated in serum from normal non-pregnant women (n=13) and women with NP (n=24) or PE (n=15), or in VEGF, oxidized low-density lipoprotein (ox-LDL), progesterone, or estradiol-17-containing medium for 24 hours...
January 15, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29334489/association-between-arterial-stiffness-and-wave-reflection-with-subsequent-development-of-placental-mediated-diseases-during-pregnancy-findings-of-a-systematic-review-and-meta-analysis
#9
Mohamed Waseem Osman, Mintu Nath, Eamonn Breslin, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
OBJECTIVE: We present a comprehensive systematic review of published literature to examine, whether arterial stiffness and wave reflection measurements during pregnancy differed between healthy patients and patients with placental-mediated diseases including preeclampsia (PET), small for gestational age (SGA), fetal death, and placental abruption, and a quantitative assessment of the findings using the meta-analysis approach. METHODS: We searched Medline, Embase, and The Cochrane Library for studies of arterial stiffness in pregnancy, analyzed pregnancy outcomes and conducted the meta-analysis of data evaluated by trimesters of pregnancy...
January 13, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29331477/atypical-presentation-of-pregnancy-related-hemolytic-uremic-syndrome
#10
Salim Baghli, Catherine Abendroth, Umar Farooq, Jennifer A Schaub
The cause of acute kidney injury during pregnancy and in the postpartum period can be particularly challenging to diagnose, especially when it is necessary to differentiate among preeclampsia; eclampsia; hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome; and thrombotic microangiopathies (TMAs). All these disease entities can present with kidney failure, microangiopathic hemolytic anemia, and thrombocytopenia. We present a teaching case of atypical hemolytic uremic syndrome in the postpartum period in a young woman who was found to have mutations of uncertain clinical significance in the complement cascade, including in C3, CFH, and CFI...
January 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29330892/ophthalmic-artery-doppler-prediction-of-preeclampsia-a-systematic-review-and-meta-analysis
#11
REVIEW
Erkan Kalafat, Ariana Laoreti, Asma Khalil, Fabricio Da Silva Costa, Basky Thilaganathan
OBJECTIVE: To determine the accuracy of ophthalmic artery Doppler in pregnancy for the prediction of preeclampsia. METHODS: MEDLINE (1947-2017), EMBASE (1974-2017), CINAHL (inception-2017) and the Cochrane Library (inception-2017) were searched for relevant citations without language restrictions. Two reviewers independently selected studies that evaluated the accuracy of ophthalmic artery Doppler to predict the development of preeclampsia and performed data extraction to construct 2 × 2 tables...
January 12, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29329728/gene-expression-patterns-associated-with-human-placental-trophoblast-differentiation
#12
Shi-Wen Jiang, Wei Zhou, Jianhao Wang, Lauren M Little, Lynn Leaphart, Jacob Jay, Eseosaserea Igbinigie, Haibin Chen, Jinping Li
Cell fusion is a hallmark of placental trophoblast cell differentiation and the mature syncytiotrophoblasts play essential roles for fetal-maternal exchange and production of pregnancy-related hormones. Using a well-established in vitro trophoblast differentiation model, we performed a microarray analysis on mRNA expression in trophoblast and syncytiotrophoblast cell cultures. Dramatic changes in gene expression patterns were detected during trophoblast differentiation. Real-time PCR analysis confirmed the reliability of the microarray data...
January 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29328602/aspirin-versus-placebo-in-pregnancies-at-high-risk-for-preterm-preeclampsia
#13
Kypros H Nicolaides
No abstract text is available yet for this article.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29328601/aspirin-versus-placebo-in-pregnancies-at-high-risk-for-preterm-preeclampsia
#14
Loïc Sentilhes, Elie Azria, Thomas Schmitz
No abstract text is available yet for this article.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29328396/placenta%C3%A2-associated-serum-exosomal-mir%C3%A2-155-derived-from-patients-with-preeclampsia-inhibits-enos-expression-in-human-umbilical-vein-endothelial-cells
#15
Li Shen, Yujing Li, Ruotian Li, Zhenyu Diao, Muyi Yany, Mengfei Wu, Haixiang Sun, Guijun Yan, Yali Hu
Preeclampsia (PE) is considered to be initiated by abnormal placentation in early pregnancy and results in systemic endothelial cell dysfunction in the second or third trimester. MicroRNAs (miRs) expressed in the human placenta can be secreted into maternal circulation via exosomes, which are secreted extracellular vesicles that serve important roles in intercellular communication. The present study hypothesized that upregulation of placenta‑associated serum exosomal miR‑155 from patients with PE may suppress endothelial nitric oxide synthase (eNOS) expression in endothelial cells...
January 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29327149/gestational-diabetes-and-risk-of-cardiovascular-disease-up-to-25%C3%A2-years-after-pregnancy-a-retrospective-cohort-study
#16
Safyer McKenzie-Sampson, Gilles Paradis, Jessica Healy-Profitós, Frédérique St-Pierre, Nathalie Auger
AIMS: The risk of cardiovascular disease in women with gestational diabetes is poorly understood. We sought to determine whether gestational diabetes increases the risk of cardiovascular disease more than two decades after pregnancy. METHODS: We carried out a retrospective cohort study of 1,070,667 women who delivered infants in hospitals within Quebec, Canada, between 1989 and 2013. We followed 67,356 women with gestational diabetes and 1,003,311 without gestational diabetes for a maximum of 25...
January 11, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29326280/autoantibodies-against-angiotensin-and-adrenergic-receptors-more-than-a-biomarker
#17
Rugina Neuman, A H Jan Danser
Agonistic autoantibodies (AAs) directed against receptors of the sympathetic nervous system and the renin-angiotensin system have been suggested to contribute to cardiovascular and renal disease, in particular hypertension, preeclampsia, and graft failure in kidney transplantation patients. Consequently, they are now also being studied as biomarker for these conditions. This commentary summarizes our current understanding of these AAs, critically discussing whether they truly act as agonist, and focusing on the wide array of assays that are currently used for their quantification...
January 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29325458/a-diagnostic-test-accuracy-meta-analysis-of-maternal-serum-ischemia-modified-albumin-for-detection-of-preeclampsia
#18
Varikasuvu Seshadri Reddy, Munikumar Manne, Pragathi Duggina, Neelakant Varma
BACKGROUND/AIMS: Ischemia-modified albumin (IMA) has been widely accepted as a serological biomarker. IMA has been proposed as a simple and novel marker of oxidative stress in preeclampsia (PE). This systematic review and diagnostic test accuracy meta-analysis aims to evaluate the diagnostic accuracy of this novel serological biomarker, IMA to detect PE. METHODS: A systematic search of major databases was performed to identify all published diagnostic accuracy studies on IMA...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29325324/-obstetric-outcome-in-pregnancy-complained-with-pulmonary-hypertension
#19
C X Zhu, W Xiong, J Yang, H Q Chen, G Niu, Z L Wang
Objective: To identify whether pregnancy outcomes vary by the severity of pulmonary hypertension. Methods: A retrospective study was conducted on 78 cases of pregnancies complained with pulmonary hypertension who delivered in the First Affiliated Hospital, Sun Yat-sen University from 2006 to 2016.The selected cases were divided into three groups according to severity of pulmonary hypertension: mild pulmonary hypertension group (mild PAH group) was defined as a mean pulmonary artery pressure 30-49 mmHg, moderate pulmonary hypertension (moderate PAH group) as mean pulmonary artery pressure 50-69 mmHg and severe pulmonary hypertension (severe PAH group) as mean pulmonary artery pressure 70 mmHg or greater...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29325127/inhibiting-trophoblast-par-1-overexpression-suppresses-sflt-1-induced-anti-angiogenesis-and-abnormal-vascular-remodeling-a-possible-therapeutic-approach-for-preeclampsia
#20
Yin Zhao, YanFang Zheng, XiaoXia Liu, QingQing Luo, Di Wu, XiaoPing Liu, Li Zou
STUDY QUESTION: Is it possible to improve vascular remodeling by inhibiting the excessive expression of protease activated receptor 1 (PAR-1) in trophoblast of abnormal placenta? SUMMARY ANSWER: Inhibition of trophoblast PAR-1 overexpression may promote placental angiogenesis and vascular remodeling, offering an alternative therapeutic approach for preeclampsia. WHAT IS KNOWN ALREADY: PAR-1 is high-affinity receptor of thrombin. Thrombin increases sFlt-1 secretion in trophoblast via the activation of PAR-1...
January 9, 2018: Molecular Human Reproduction
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