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Farahnaz Keshavarzi, Shervin Mehdizadeh, Habibolah Khazaie, Mohammad Rasoul Ghadami
OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP) > 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (+ 1 in dipsticks) in random samples...
July 19, 2018: Hypertension in Pregnancy
Frederick Odun-Ayo, Jagidesa Moodley, Thajasvarie Naicker
OBJECTIVE: To determine the level and effect of urinary clusterin (CLU) and glutathione-s-transferase (GST) proteins in normotensive and preeclamptic pregnant women with HIV infection. METHODS: The urine concentration of CLU and GST in normotensive (n = 38) and preeclamptic pregnant (n = 38) women stratified by HIV status were estimated using the Bio-Plex® ProTM immunoassay. RESULTS: Across the group, a significant down-regulation of CLU (p = 0...
July 19, 2018: Hypertension in Pregnancy
Ranjeeta Gadde, Dayanand Cd, S R Sheela
Placental protein 13 (PP13), a glycan binding protein predominantly expressed in syncytiotrophoblast, dimeric in nature, lacks N-terminal signal peptide, bypasses the endoplasmic reticulum, and secretes into maternal circulation as exosomes or microvesicles. PP13 has jelly roll fold conformation with conserved carbohydrate recognition domain which specifically binds to β-galactosides of the glycan receptors during placentation. PP13 binds to glycosylated receptors on human erythrocytes and brings about hemagglutination by the property of lectin activity; other functions are immunoregulation and vasodilation during placentation and vascularization...
January 2018: Journal of Circulating Biomarkers
Hilary S Gammill, Rakesh Chettier, Alina Brewer, James M Roberts, Raj Shree, Eleni Tsigas, Kenneth Ward
Background -Preeclampsia (PE), is associated with diastolic dysfunction, peripartum cardiomyopathy (CM), and both preexisting and subsequent maternal cardiovascular disease (CVD). Gene mutations causing idiopathic CM were recently implicated in peripartum CM. We sought to determine whether CM gene mutations are also a contributory factor in PE. Methods -Subjects were participants in The Preeclampsia Registry and Biobank. After providing informed consent, subjects with a history of PE completed a detailed questionnaire and provided medical records for diagnostic confirmation...
July 18, 2018: Circulation
Zhi-Hui Xiong, Jing Wei, Meng-Qi Lu, Mei-Yuan Jin, Hong-Ling Geng
AIM: This study aims to investigate the effect of human umbilical cord mesenchymal stem cell exosomes (hucMSC-Ex) on placental tissue and angiogenesis in rats with preeclampsia (PE). METHOD: The expression of MSC surface markers were identified by flow cytometry. Alizarin red staining and oil red O staining were used to examine osteogenic and adipogenic differentiation of hucMSCs. Western blotting was used to determine expressions of CD63 and CD81 in hucMSC-Ex. PE rat models were established using endothelial nitric oxide synthase, eNOS)NG -Nitro-l-arginine Methyl Ester, which were then treated with exosome (Exo) of low dosage (L-Exo), Exo of medium dosage (M-Exo) and Exo of high dosage (H-Exo)...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
N Auger, M Duplaix, M Bilodeau-Bertrand, E Lo, A Smargiassi
No abstract text is available yet for this article.
October 2018: Environmental Pollution
Linda J E Meertens, Hubertina C J Scheepers, Sander M J van Kuijk, Robert Aardenburg, Ivo M A van Dooren, Josje Langenveld, Annemieke M van Wijck, Iris M Zwaan, Marc E A Spaanderman, Luc J M Smits
INTRODUCTION: This study assessed the external validity of all published first trimester prediction models for the risk of preeclampsia (PE) based on routinely collected maternal predictors. Moreover, the potential utility of the best-performing models in clinical practice was evaluated. MATERIAL AND METHODS: Ten prediction models were systematically selected from the literature. We performed a multicenter prospective cohort study in the Netherlands between July 1, 2013, and December 31, 2015...
July 18, 2018: Fetal Diagnosis and Therapy
Xuan Shao, Yongqing Wang, Yanlei Liu, Xuejiang Guo, Dong Li, Ran Huo, Wentong Jia, Guangming Cao, Yu-Xia Li, Ming Liu, Jiahao Sha, Yangyu Zhao, Yan-Ling Wang
BACKGROUND: Preeclampsia, a serious pregnancy-associated syndrome, is the leading cause of maternal and perinatal morbidity and mortality. Significant exacerbation of the hypercoagulation status as well as imbalanced steroid hormones have been reported in developed preeclampsia. However, it remains unclear whether the two pathological changes are directly associated. METHOD AND RESULTS: Our proteomic analysis revealed a significantly elevated SerpinF2/α2-antiplasmin level in preeclampsia plasma...
July 16, 2018: Journal of Hypertension
Jose Ramon Duncan, Ana Marie Tobiasz, Zoran Bursac, Eric Vincent Rios-Doria, Mauro Humberto Schenone, Giancarlo Mari
OBJECTIVE: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term. METHODS: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Our primary outcome was to compare the UtAPI-AP and UtAPI-PP between subjects with HTNP (gestational hypertension, preeclampsia with and without severe features) and normotensive participants...
July 18, 2018: Hypertension in Pregnancy
Hyeon Ji Kim, Shin Ho Yang, Sun Hye Yang, Seung Su Han, Gwang Jun Kim
Paraganglioma in pregnancy is an extremely rare condition and its diagnosis is often delayed because the clinical symptoms can mimic those of preeclampsia or gestational hypertension. Here, we report the case of a 32-year-old, gravida 2, para 1 woman who presented with severe headache, palpitation, and sweating at 37 weeks' gestation. Although emergent cesarean section was performed on the assumption of severe preeclampsia, blood pressure fluctuated and heart rate remained tachycardiac. We suspected that she might have thromboembolic lesion in the chest or pheochromocytoma...
July 2018: Obstetrics & Gynecology Science
Timothy Wen, Jason D Wright, Dena Goffman, Mary E D'Alton, William J Mack, Frank J Attenello, Alexander M Friedman
BACKGROUND: There is limited data on when postpartum readmissions for thromboembolism occur after delivery hospitalizations on a population basis in the United States. OBJECTIVE: To characterize risk factors for and timing of postpartum venous thromboembolism (VTE) readmission after delivery hospitalization discharge. STUDY DESIGN: The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk for readmission for venous thromboembolism within 60 days of discharge from a delivery hospitalization...
July 11, 2018: American Journal of Obstetrics and Gynecology
José L Mansura
The main source of vitamin D is produced by the exposure of sunlight on the skin. It has been proven that the deficit is frequent and also occurs in pregnant women. Possible consequences may be preeclampsia and others. The level of vitamin D in breast milk depends on the level of the mother, so that deficient mothers produce milk with low concentration. Possible consequences for the baby are rickets and seizures, but also lower respiratory tract infections or risk of type 1 diabetes. Various suggestions have been published...
August 1, 2018: Archivos Argentinos de Pediatría
Hongxia Li, Guangming Cao, Nawei Zhang, Tong Lou, Qiushi Wang, Zhenyu Zhang, Chongdong Liu
Insufficient trophoblast invasion is associated with preeclampsia (PE) development. Retinol-binding protein 4 (RBP4) is important for regulating cell differentiation, migration and invasion. The aim of the present study was to determine RBP4 expression and function in the human placenta and to examine the underlying mechanisms. In the present study, RBP4 expression was determined in serum samples from 35 pregnant women with PE and 30 healthy pregnant women using enzyme-linked immunosorbent assays. Cell proliferation was assessed by Cell Counting Kit-8 assays, and cell invasion was examined with transwell assays...
July 3, 2018: Molecular Medicine Reports
Chunhong Liu, Feng Xing, Yuanying He, Shanshan Zong, Chengfeng Luo, Chunqing Li, Tao Duan, Kai Wang, Qian Zhou
Aberrant gene expression during placental development may affect fetal growth and contribute to preeclampsia. The high‑temperature requirement A (HTRA) family of proteins are serine proteases that may serve in the quality control of misfolded or mislocalized proteins. Recently, the potential involvement of HTRA1 and HTRA4 in the normal development of the placenta and in the pathogenesis of preeclampsia has been reported. The present study collected placental tissues from patients with severe preeclampsia and gestational age‑matched control samples...
July 16, 2018: Molecular Medicine Reports
Li-Juan Lv, Lin-Lin Wu, Ji-Ying Wen, Qiong Lei, Jun Miao, Hong-Li Duan, Wen-Jie Ji, Dong-Mei Duan, Yi-Fei Luo, Li Xiao, Bin Li, Yu-Ming Li, Xin Zhou, Jian-Min Niu
BACKGROUND: The associations between umbilical cord coiling, feto-placental vascular resistance and maternal blood pressure (BP) are not well understood. METHOD: We retrospectively analyzed 502 pregnant women suspected of hypertensive disorders in the third trimester from a hospital-based cohort, who underwent ambulatory BP monitoring and umbilical artery Doppler velocimetry examinations within 14 days before delivery. By applying quantile regression, a significant quantile-dependent positive association between umbilical cord coiling index and umbilical artery pulsatility index (UAPIMOM; converted to multiples of median) was observed from above 0...
July 13, 2018: Journal of Hypertension
Martin R Salazar, Walter G Espeche, Carlos E Leiva Sisnieguez, Betty C Leiva Sisnieguez, Eduardo Balbín, Rodolfo N Stavile, Carlos March, Ricardo D Olano, Adelaida Soria, Osvaldo Yoma, Marcelo Prudente, Soledad Torres, Florencia Grassi, Claudia Santillan, Horacio A Carbajal
OBJECTIVE: The aim of this study was to test if hypertension detected by ambulatory blood pressure monitoring (ABPM) performed at mid-pregnancy, is a useful predictor for preeclampsia/eclampsia (PEEC). METHODS: The study was performed in women coursing high-risk mid-pregnancies. Office blood pressure (BP) was estimated as the mean of three values, taken by a specialized nurse after a 15-min interview, and office hypertension defined as at least 140/90 mmHg. Immediately after, an ABPM was started...
July 13, 2018: Journal of Hypertension
H Zeisler, E Llurba, F J Chantraine, M Vatish, A C Staff, M Sennström, M Olovsson, S P Brennecke, H Stepan, D Allegranza, M Schoedl, S Grill, M Hund, S Verlohren
OBJECTIVE: The soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is mostly elevated some time before and at the clinical onset of preeclampsia. The PROGNOSIS study validated a ratio cut-off of ≤ 38 to rule out onset of preeclampsia for 1 week in women with suspected disease. This analysis assessed the mid-term predictive value of the sFlt-1/PlGF ratio and the effect of repeat measurement vs a single test. METHODS: An exploratory post-hoc analysis of data from PROGNOSIS was performed in pregnant women (≥ 18 years, gestational weeks 24 + 0 to 36 + 6 days at Visit 1) with suspected preeclampsia...
July 16, 2018: Ultrasound in Obstetrics & Gynecology
Jean Guglielminotti, Ruth Landau, Cynthia A Wong, Guohua Li
Background The incidence of severe maternal morbidity (SMM) during childbirth is increasing in the United States. A better characterization of risk factors for SMM may identify targets for improving maternal outcomes. This study aims to characterize patient-, hospital-, and neighborhood-level factors associated with SMM during childbirth. Methods SMM during childbirth was identified in the 2013-2014 State Inpatients Database for New York. Hospital and neighborhood characteristics were abstracted from the American Hospital Association and the Area Health Resources files...
July 16, 2018: Maternal and Child Health Journal
Tijana Drobnjak, Hamutal Meiri, Maurizio Mandalá, Berthold Huppertz, Sveinbjörn Gizurarson
Introduction: Human placental protein 13 (PP13) is a galectin predominantly expressed by the placenta. Low serum concentrations of PP13 in early pregnancy indicate a higher risk of developing preeclampsia. Methods: The pharmacokinetic disposition and bioavailability of PP13 were determined by single intravenous and subcutaneous administration to 12 healthy New Zealand White rabbits. The serum pharmacokinetic values were determined by enzyme-linked immunosorbent assay, and are best described by a two-compartment model...
2018: Drug Design, Development and Therapy
Venkata Ramana Vaka, Kristen M McMaster, Mark W Cunningham, Tarek Ibrahim, Rebekah Hazlewood, Nathan Usry, Denise C Cornelius, Lorena M Amaral, Babbette LaMarca
Placental ischemia is believed to be the initial event in the development of preeclampsia. Mitochondrial dysfunction is a cause of reactive oxygen species (ROS) generation and oxidative stress, however, there are not many studies examining the role of mitochondrial ROS in the pathology of preeclampsia. The purpose of this study was to not only examine the effect of placental ischemia on mitochondrial-mediated oxidative stress in reduced uterine perfusion pressure (RUPP) rat model of preeclampsia but to also examine the role of mitochondrial ROS in contributing to hypertension in response to placental ischemia...
July 16, 2018: Hypertension
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