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gallbladder diseases

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https://www.readbyqxmd.com/read/29238914/clinical-and-genetic-implications-of-dna-mismatch-repair-deficiency-in-biliary-tract-cancers-associated-with-lynch-syndrome
#1
Jordan M Cloyd, Yun Shin Chun, Naruhiko Ikoma, Jean Nicolas Vauthey, Tlhomas A Aloia, Amanda Cuddy, Miguel A Rodriguez-Bigas, Y Nancy You
PURPOSE: Patients with Lynch syndrome (LS) have a significantly elevated lifetime risk of developing biliary tract cancers (BTCs) compared to the general population. However, few studies have characterized the clinical characteristics, genetic features, or long-term outcomes of mismatch-repair deficient (dMMR) cholangiocarcinomas associated with LS. METHODS: A retrospective review of a prospectively maintained Familial High-Risk GI Cancer Clinic database identified all patients with BTCs evaluated from 2006 to 2016 who carried germline mutations in MLH1, MSH2, MSH6, or PMS2...
December 14, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29234972/staging-treatment-and-future-approaches-of-gallbladder-carcinoma
#2
REVIEW
Sanjeev Kumar Shukla, Govind Singh, K S Shahi, Bhuvan, Prabhat Pant
BACKGROUND: Gallbladder cancer is the most common malignant cancer of the bile ducts and third most common gastrointestinal malignant in the world for public health. Its relatively low incidence and confused symptoms result in advanced disease at the time of presentation, contributing to poor prognosis and reduced survival associated with this disease. The main function of the gallbladder is to store excreted bile acids from the liver in preparation for a meal. Its main risk factor is prolonged exposure to biliary calculations, although bacterial infections and other inflammatory conditions are associated...
December 12, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29234813/hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#3
Gerald Gartlehner, Sheila V Patel, Cynthia Feltner, Rachel Palmieri Weber, Rachel Long, Kelly Mullican, Erin Boland, Linda Lux, Meera Viswanathan
Importance: Postmenopausal status coincides with increased risks for chronic conditions such as heart disease, osteoporosis, cognitive impairment, or some types of cancers. Previously, hormone therapy was used for the primary prevention of these chronic conditions. Objective: To update evidence for the US Preventive Services Task Force on the benefits and harms of hormone therapy in reducing risks for chronic conditions. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries from June 1, 2011, through August 1, 2016...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29231557/-discussion-on-rules-of-acupoint-selection-for-vascular-dementia
#4
Shuai Li, Jie Tan, Hong Zhang, Guilan Huang, Duoxi Deng, Quanrui Jiang
OBJECTIVE: The clinical research literature regarding acupuncture treatment for vascular dementia was reviewed and analyzed to provide the references for clinical selection and compatibility of acupoints. METHODS: With computer and manual retrieval method, the clinical literature regarding acupuncture treatment for vascular dementia in recent 10 years was collected. The acupoint type, meridian and use frequency were analyzed. RESULTS: Totally 38 articles of acupuncture treatment for vascular dementia were screened; the most selected meridians were the governor vessel, gallbladder meridian, stomach meridian and spleen meridian; the main acupoints with frequency of more than 5 times were Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV 24), Fengchi (SP 40) and Shuigou (GV 26); the matching acupoints with frequency of more than 5 times were Fenglong (ST 40), Zusanli (ST 36), Taichong (LR 3), Taixi (KI 3), Sanyinjiao (SP 6), Xuehai (SP 10), Zhongwan (CV 12), Neiguan (PC 6), Fengchi (GB 20)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29225328/gallbladder-hypoplasia-a-congenital-abnormality-of-the-gallbladder-a-case-report
#5
Christophoros S Kosmidis, Georgios D Koimtzis, Maria S Kosmidou, Fotini Ieridou, Triantafyllia Koletsa, Katerina T Zarampouka, Eleni Georgakoudi, Isaac Kesisoglou
BACKGROUND There are different variations in the anatomy of the gallbladder. Congenital abnormalities of the gallbladder such as agenesis and hypoplasia are rare conditions and difficult to diagnose with imaging studies. Patients are usually asymptomatic or have symptoms that mimic gallstone disease. The diagnosis is often made intraoperatively and is established by histopathological examination. CASE REPORT We report a case of a 62-year-old male who had cholelithiasis symptoms and was falsely diagnosed with gallstone disease by abdominal ultrasound scan...
December 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29221432/sex-and-ethnic-racial-specific-risk-factors-for-gallbladder-disease
#6
Jane C Figueiredo, Christopher Haiman, Jacqueline Porcel, James Buxbaum, Daniel Stram, Neal Tambe, Wendy Cozen, Lynne Wilkens, Loic Le Marchand, Veronica Wendy Setiawan
BACKGROUND: Gallbladder disease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations. METHODS: We performed a prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Native Hawaiian (n = 6942) and Latino (n = 39,168)...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29217907/synchronous-breast-cancer-and-gallbladder-diseases-a-chromosomal-analysis-a-pilot-study-at-a-tertiary-care-centre
#7
Devendra Chaudhary, Rahul Ahluwalia, Arvind Rai
Out of a total of 50 study-eligible patients, 15 patients were found to have synchronous breast cancer and gallbladder diseases. Fourteen such patients had breast cancer and cholelithiasis while 1 patient had breast cancer with gallbladder cancer. Amongst these 15 patients, 7 patients tested positive for chromosomal aberrations on karyotyping. Aberrations in these patients were seen on chromosomes 13 and 17 with 2 patients having deletion 13q, 2 having deletion 17q, and 2 having deletions on 17p while one patient had multiple deletions on chromosomes 13q and 17p...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29214888/minimally-invasive-surgical-approach-for-radicalization-of-incidental-post-cholecystectomy-gallbladder-carcinoma-safety-feasibility-and-outcomes
#8
Emanuele Sinagra, Stefano Garritano, Salvatore Marco Iacopinelli, Marco Messina, Dario Raimondo, Francesca Rossi, Massimiliano Spada, Guido Martorana, Marcello Giuseppe Spampinato
BACKGROUND AND AIMS: Gallbladder carcinoma is a rare but aggressive malignant neoplasm. The incidence of intra- or post-operative incidental gallbladder carcinoma diagnosis following laparoscopic cholecystectomy is estimated to be 1-2%. Aggressive re-resection is warranted as the majority of patients have residual disease either in the liver or the lymph nodes. However the use of a minimally invasive surgical approach (MISA) to perform a radicalization in these patients has not been investigated yet...
December 7, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29212080/clinical-evaluation-of-continuous-renal-replacement-therapy-in-combination-with-ultrasound-guided-percutaneous-transhepatic-gallbladder-drainage-for-acute-severe-biliary-pancreatitis-a-retrospective-study
#9
Qingyun Zhu, Xinting Pan, Yongxian Cao, Hongqiao Wang, Ning Yu, Fuguo Liu, Shigang Yang, Yunlong Wang, Yunbo Sun, Zhengbin Wang
BACKGROUND/AIMS: This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS: Between January 2010 and January 2016, 40 cases of patients with ASBP who received routine CRRT (CRRT group) and 40 of those who received CRRT+PTGD (CRRT+PTGD group) at the Affiliated Hospital of Qingdao University (Qingdao, China) were retrospectively reviewed...
November 30, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29209116/gastric-xanthelasma-and-metabolic-disorders-a-large-retrospective-study-among-chinese-population
#10
Yi Chen, Xin-Jue He, Min-Jian Zhou, You-Ming Li
AIM: To gain knowledge of xanthelasma, a large population-based study was conducted. METHODS: Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China during Jan 2009 to Nov 2016 were included. General characteristics as well as clinical data were collected, including blood routine, serum biochemical analysis, endoscopic findinds, histological evaluation and comorbiditie. Statistical analyses was performed using SPSS 20...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29205503/gallbladder-mucocele-variables-associated-with-outcome-and-the-utility-of-ultrasonography-to-identify-gallbladder-rupture-in-219-dogs-2007-2016
#11
J A Jaffey, A Graham, E VanEerde, E Hostnik, W Alvarez, J Arango, C Jacobs, A E DeClue
BACKGROUND: Gallbladder mucocele (GBM) is an increasingly recognized extrahepatic biliary disease in dogs. OBJECTIVES: To investigate cases of GBM and identify variables associated with survival and the sensitivity and specificity of ultrasonography to identify gallbladder rupture. ANIMALS: Two hundred and nineteen client-owned dogs with GBM. METHODS: Multicenter, retrospective study of dogs with GBM, presented from January 2007 to November 2016 to 6 academic veterinary hospitals in the United States...
December 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29201805/porcelain-gallbladder
#12
Apoorv Goel, Ayush Agarwal, Shalabh Gupta, Tripta S Bhagat, Gaurav Kumar, Atul K Gupta
Porcelain gallbladder or calcified gallbladder is a rare entity and is considered as the end stage of chronic cholecystitis. This disease is rarely diagnosed preoperatively and usually mimics carcinoma gallbladder. Hereby, we present a rare and interesting case of porcelain gallbladder that was diagnosed preoperatively and managed by cholecystectomy. How to cite this article: Goel A, Agarwal A, Gupta S, Bhagat TS, Kumar G, Gupta AK. Porcelain Gallbladder. Euroasian J Hepato-Gastroenterol 2017;7(2):181-182.
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29199665/metastasectomy-for-recurrent-or-metastatic-biliary-tract-cancers-a-single-center-experience
#13
I Park, Y S Kim, S J Sym, H K Ahn, K K Kim, Y H Park, J N Lee, D B Shin
PURPOSE: To assess efficacy or long-term result of metastasectomy for recurrent or metastatic biliary tract carcinoma (BTC), we conducted a retrospective review of the outcomes of metastasectomy for recurrent or metastatic BTCs, comprising intrahepatic cholangiocellular carcinoma (IHCCC), proximal and distal common bile duct cancer (pCBDC and dCBDC), gallbladder cancer (GBC), and ampulla of Vater cancer (AoVC). PATIENTS AND METHODS: The clinicopathological features and outcomes of BTC patients who underwent surgical resection for the primary and metastatic disease at the Gachon University Gil Medical Centre from 2003 to 2013 were reviewed retrospectively...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29197189/incidental-gallbladder-cancer-at-cholecystectomy
#14
Faik Tatli, Abdullah Ozgönül, Yusuf Yucel, Hüseyin Cahit Yalcin, Resit Ciftci, Mehmet Gümer, Firat Erkmen, Rabia Altuntas, Ali Uzunkoy
BACKGROUND: Gallbladder tumours rank fifth in the world among gastrointestinal system tumours. Coincidental gallbladder tumours are diagnosed during cholecystectomies, or by examining the cholecystectomy material. AIMS: In this study, we aimed to evaluate the incidence of gallbladder cancer among patients undergoing cholecystectomies due to gallbladder disease. STUDY DESIGN: Retrospective study METHODS: The files of 341 patients who had undergone routine cholecystectomy operations between January 2013 and March 2016 were reviewed, and their pathology results were recorded...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29195671/alcohol-smoking-and-benign-hepato-biliary-disease
#15
REVIEW
Daniel Mønsted Shabanzadeh, Srdan Novovic
Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29191686/ct-features-of-hepatic-veno-occlusive-disease-a-meta-analysis
#16
Song Yang, Jing Wu, Si Lei
RATIONALE AND OBJECTIVE: The computed tomography (CT) features of hepatic veno-occlusive disease (HVOD) could play a role in its diagnosis. We aimed to perform a meta-analysis of studies examining the CT features of HVOD. METHODS: Relevant studies published up to May 3, 2017 were searched in major electronic databases. The extracted data included the proportion of various CT features in patients with HVOD. The meta-analysis was conducted using R 3.3.3 with the "meta" package...
November 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29188076/epithelial-to-mesenchymal-transition-in-gallbladder-cancer-from-clinical-evidence-to-cellular-regulatory-networks
#17
REVIEW
Sunwang Xu, Ming Zhan, Jian Wang
Gallbladder cancer (GBC), with late diagnosis, rapid disease progression and early metastasis, is a highly aggressive malignant tumor found worldwide. Patients with GBC have poor survival, low curative resection rates and early recurrence. For such a lethal tumor, uncovering the mechanisms and exploring new strategies to prevent tumor progression and metastasis are critically important. Epithelial-to-mesenchymal transition (EMT) has a prominent role in the early steps of tumor progression and metastasis by initiating polarized epithelial cell transition into motile mesenchymal cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/29187474/plasma-glutathione-peroxidase-gpx1-levels-and-oxidative-stress-in-gallstone-patients-operated-with-two-different-cholecystectomy-techniques-a-randomized-study-with-special-reference-to-cancer-patients
#18
Jari Kärkkäinen, Samuli Aspinen, Jukka Harju, Petri Juvonen, Kari Pulkki, Matti Eskelinen
BACKGROUND/AIM: The plasma glutathione peroxidase (GPX1) levels in gallstone patients operated with laparoscopic cholecystectomy (LC) or minicholecystectomy (MC) versus cancer patients is unknown. PATIENTS AND METHODS: Initially, 114 patients with symptomatic gallstone disease were randomized into LC (n=53) or MC (n=61) groups. Plasma levels of C-reactive protein (hs-CRP) and the oxidative stress marker GPX1 were measured at three time points; before (PRE), immediately after (POP1) and 6 hours after operation (POP2)...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29183521/utility-of-laparoscopic-subtotal-cholecystectomy-with-or-without-cystic-duct-ligation-for-severe-cholecystitis
#19
Shoji Hirajima, Toshimori Koh, Tomohito Sakai, Taisuke Imamura, Shunji Kato, Yukihisa Nishimura, Koji Soga, Minoru Nishio, Atsushi Oguro, Noboru Nakagawa
We use open cholecystectomy (OC) to treat severe cholecystitis in cases in which we are worried that inflammation might cause anatomical changes in Calot's triangle. Furthermore, in cases of severe cholecystitis in which marked inflammation leads to fibrosis, we perform subtotal cholecystectomy (SC), i.e., incomplete gallbladder resection. Laparoscopic SC (LSC) without cystic duct dissection is considered to be effective at reducing the incidence of serious complications in patients with severe cholecystitis...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29178198/association-between-helicobacter-pylori-infection-and-gallbladder-diseases-a-retrospective-study
#20
Mei-Yan Xu, Jia-Hui Ma, Bao-Shi Yuan, Jian Yin, Lan Liu, Qing-Bin Lu
BACKGROUND AND AIMS: The association between Helicobacter pylori (H. pylori) and gallbladder diseases is still unclear and is controversial. We conducted a retrospective study to clarify the prevalence of gallbladder diseases, and factors related to gallbladder diseases, and relationships between H. pylori infection, gallstones, cholecystitis and cholecystic polypus. METHODS: The retrospective study was performed at the Aerospace Center Hospital in Beijing. The subjects in this study were a healthy population who underwent health examinations at the hospital between 2012 and 2015...
November 27, 2017: Journal of Gastroenterology and Hepatology
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