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https://www.readbyqxmd.com/read/28735098/cholangiocytes-cell-transplantation
#1
REVIEW
Lorenzo Ridola, Maria Consiglia Bragazzi, Vincenzo Cardinale, Guido Carpino, Eugenio Gaudio, Domenico Alvaro
BACKGROUND: Due to significant limitations to the access to orthotropic liver transplantation, cell therapies for liver diseases have gained large interest worldwide. SCOPE OF REVIEW: To revise current literature dealing with cell therapy for liver diseases. We discussed the advantages and pitfalls of the different cell sources tested so far in clinical trials and the rationale underlying the potential benefits of transplantation of human biliary tree stem cells (hBTSCs)...
July 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28733222/molecular-classification-of-hepatocellular-adenoma-in-clinical-practice
#2
REVIEW
Jean-Charles Nault, Valérie Paradis, Daniel Cherqui, Valérie Vilgrain, Jessica Zucman-Rossi
Incidental liver lesion depicted on preoperative imaging for bariatric surgery (BMI = 42) in a 34 year-old woman with oral contraceptive use of 15 years, normal blood liver tests and high CRP (11 mg/L, Nl <6). MRI showed a 6 cm liver nodule in segment V close to the gallbladder. The nodule was moderately hyperintense on T1 (in-phase) and showed a marked and heterogeneous drop in signal intensity on opposedphase sequence suggesting the presence of fat. On T2, the nodule was heterogeneous, hyperintense at the periphery and hypointense in most of the central part...
July 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28731820/uncommon-neoplasms-of-the-biliary-tract-radiological-findings
#3
Vincenza Granata, Roberta Fusco, Orlando Catalano, Salvatore Filice, Antonio Avallone, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Roberto Grassi, Francesco Izzo, Antonella Petrillo
OBJECTIVES: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features. METHODS: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-, and late-phase on US, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary-phase on MRI...
July 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28730246/spontaneous-cholecystocutaneous-fistula-as-a-primary-manifestation-of-gallbladder-adenocarcinoma-associated-with-gallbladder-lithiasis-case-report
#4
Bogdan Vasile Micu, Octavian Aurel Andercou, Carmen Maria Micu, Valentin Militaru, IonuŢ Isaia Jeican, Cătălina Ileana Bungărdean, Stelian ŞtefăniŢă Mogoantă, Dan Radu Miclăuş, Tudor Radu Pop
Spontaneous cholecystocutaneous fistula (SCF) is a rare complication of neglected calculous biliary disease and also an extremely rare complication of gallbladder neoplasm. This pathology has become even rarer because of prompt diagnosis and expedient surgical intervention for gallstones. So far, there is one published report of a SCF due to gallbladder adenocarcinoma. We present the case of a woman aged 87 years, admitted to the Vth Department of Surgery, Clinical Municipal Hospital of Cluj-Napoca (Romania) for a tumoral mass located in the epigastrium...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28719966/safety-and-complications-of-interventional-endoscopic-ultrasound
#5
Monica Saumoy, Michel Kahaleh
Endoscopic ultrasound (EUS) has become an essential tool for the diagnostic and therapeutic intervention of gastrointestinal diseases. Beyond the drainage of fluid collections, it enables decompression of inaccessible bile and pancreatic ducts, the gallbladder, and the creation of anastomosis within the gastrointestinal tract using fully lumen-apposing stents. This review explored the safety and efficacy of these novel procedures and discussed the training pathway that is necessary to perform them efficiently and safely...
July 19, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28709483/what-remains-to-surgeons-in-the-management-of-abdominal-tuberculosis-a-10-years-experience-in-an-endemic-area
#6
Rabii Noomene, Asma Ouakaa, Raja Jouini, Anis Ben Maamer, Abderraouf Cherif
BACKGROUND: Tuberculosis (TB) is a common endemic disease in Tunisia. Abdominal location is rare. Early diagnosis of abdominal TB remains difficult due to its non-specific clinical presentations. The aim of our study is to highlight the characteristics of the different presentations, to characterize tools contributing to a positive preoperative diagnosis, and finally to assess the role of surgery in the management of this entity. MATERIALS AND METHODS: A retrospective review from 2005 to 2015 identified 90 cases of confirmed abdominal TB managed in the Department of General Surgery of the Habib Thameur Hospital...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28706888/comparison-of-the-outcomes-of-robotic-cholecystectomy-and-laparoscopic-cholecystectomy
#7
Eun Kyoung Lee, Eunyoung Park, Won-Oak Oh, Nah-Mee Shin
PURPOSE: This study compared the effects of robotic single-port cholecystectomy (RC) and 3-port laparoscopic cholecystectomy (LC) on patients' surgical pain, postoperative complications, and satisfaction. METHODS: One hundred twenty patients with gallbladder disease scheduled for either LC or RC were recruited. Each patient was followed up for 1 week after hospital discharge. RESULTS: Time stayed in operating room was longer in patients with RC, however their hospital stay was shorter than those with LC (t = 3...
July 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28702136/chronic-cholecystitis-in-the-pediatric-population-an-underappreciated-disease-process
#8
Brian P Blackwood, Julia Grabowski
AIM: We hypothesize that chronic cholecystitis accounts for the majority of inflammatory diseases in the pediatric population and it is difficult to predict with preoperative ultrasound. BACKGROUND: Despite the increase in gallbladder disease, there is a paucity of data on pediatric cholecystitis. Most pediatric studies focus on cholelithiasis and biliary dyskinesia rather than inflammatory gallbladder disease. METHODS: We performed a single center retrospective review of all patients who underwent cholecystectomy from 1/1/10 - 1/1/15...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28695876/impact-of-obesity-on-surgical-outcome-after-single-incision-laparoscopic-cholecystectomy
#9
Toru Obuchi, Noriaki Kameyama, Masato Tomita, Hiroaki Mitsuhashi, Ryohei Miyata, Shigeaki Baba
INTRODUCTION: Single-incision laparoscopic cholecystectomy (SILC) is widely used as a treatment option for gallbladder disease. However, obesity has been considered a relative contraindication to this approach due to more advanced technical difficulties. The aim of this report was to review our experience with SILC to evaluate the impact of body mass index (BMI) on the surgical outcome. PATIENTS AND METHODS: Between May 2009 and February 2013, 237 patients underwent SILC at our institute...
July 7, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28695432/gallbladder-polypoid-lesions-what-are-they-and-how-should-they-be-treated-a-single-center-experience-based-on-1446-cholecystectomy-patients
#10
Anan Xu, Yu Zhang, Hai Hu, Gang Zhao, Jinli Cai, Anhua Huang
BACKGROUND AND AIM: Gallbladder polypoid-lesions (GPs) are commonly seen on ultrasonography (USG), but several aspects of this problem are ill-defined. This study aimed to analyze clinic and pathologic characteristics of 1446 USG-detected GPs, identify predictive factors for cholesterol lesions and malignancy, and provide comments and recommendations on specific aspects of GPs. METHODS: We retrospectively analyzed clinic files of 1446 patients who underwent cholecystectomy for USG-detected GPs between 2008 and 2015 in Gallbladder Diseases Center, East Hospital of Tongji University...
July 10, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28693792/cholangiocarcinoma
#11
REVIEW
Michela Squadroni, Luca Tondulli, Gemma Gatta, Stefania Mosconi, Giordano Beretta, Roberto Labianca
Biliary tract cancer accounts for <1% of all cancers and affects chiefly an elderly population, with predominance in men. We distinguish cholangiocarcinoma (intrahepatic, hilar and distal) and gallbladder cancer, with different pathogenesis and prognosis. The treatment is based on surgery (whenever possible), radiotherapy in selected cases, and chemotherapy. The standard cytotoxic treatment for advanced/metastatic disease is represented by the combination of gemcitabine and cisplatin, whereas fluoropyrimidines are generally administered in second line setting...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28692469/surgical-management-of-gallbladder-cancer-simple-versus-extended-cholecystectomy-and-the-role-of-adjuvant-therapy
#12
Gyulnara G Kasumova, Omidreza Tabatabaie, Robert M Najarian, Mark P Callery, Sing Chau Ng, Andrea J Bullock, Robert A Fisher, Jennifer F Tseng
OBJECTIVE: To assess if simple cholecystectomy with adjuvant therapy could provide outcomes comparable to extended cholecystectomy. BACKGROUND: Current guidelines recommend extended/radical cholecystectomy for T2/T3 gallbladder cancer; however, many tumors are discovered incidentally at laparoscopic cholecystectomy. METHODS: The national Cancer Data Base 2004 to 2014 was queried for patients with pT2/T3 gallbladder adenocarcinoma who underwent resection...
July 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28683987/node-negative-esophageal-cancer-with-short-interval-isolated-metastasis-to-the-gallbladder-a-case-report
#13
Christopher M Hart, Kelly R Haisley, Christian Lanciault, James P Dolan
A 55 year old male smoker presented with clinical T3N0 esophageal adenocarcinoma of the GE junction. He completed neoadjuvant chemoradiotherapy with carboplatin/paclitaxel and 5040cGy of radiation. He had limited clinical response on restaging but no evidence of metastatic disease and completed a minimally invasive three field esophagectomy. This was complicated by a chyle leak requiring thoracic duct embolization from which he recovered well. Surgical pathology showed no apparent nodal disease or metastases but a poorly differentiated primary tumor with signet-cell features...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28682919/successful-treatment-using-corticosteroid-combined-antibiotic-for-acute-acalculous-cholecystitis-patients-with-systemic-lupus-erythematosus
#14
Wei Liu, Weijie Chen, Xiaodong He, Qiang Qu, Tao Hong, Binglu Li
There is no consensus of treatments for acute acalculous cholecystitis with systemic lupus erythematosus (SLE). The study was aimed to investigate the effect of the corticosteroid for these patients.A series of patients who were diagnosed as acute acalculous cholecystitis with SLE in the period from January 2012 to December 2016 at our hospital were included. They accepted 2 different conservative treatment strategies initially: the treatment using moxifloxacin (the antibiotic group), and the treatment using corticosteroid combined moxifloxacin (the corticosteroid group)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28680009/contrast-enhanced-harmonic-endoscopic-ultrasonography-in-gallbladder-cancer-and-pancreatic-cancer
#15
Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Yuki Sato, Takuto Hikichi, Hiromasa Ohira
Endoscopic ultrasonography (EUS) plays a major role in diagnosing gallbladder (GB) cancer and pancreatic cancer (PC). In cases of GB cancer, EUS allows for precise observations of morphology and wall layers. However, proficiency is required for the morphologic diagnosis of GB tumors. Therefore, contrast-enhanced harmonic EUS (CH-EUS) began to be performed to diagnose GB lesions. CH-EUS enables real-time observation of the hemodynamics of GB tumors. The enhanced patterns generated by CH-EUS improve precision in the diagnosis of such tumors...
July 5, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28677740/isoform-switch-of-cd44-induces-different-chemotactic-and-tumorigenic-ability-in-gallbladder-cancer
#16
Takeshi Miwa, Takuya Nagata, Hirofumi Kojima, Shinichi Sekine, Tomoyuki Okumura
Gallbladder cancer (GBC) is one of the most unfavorable prognostic tumor, and immediate growth and distant metastasis are important factors associated with the poor prognosis of patients with this disease. Standard and variant isoforms of CD44 are associated with tumor growth, metastasis, and epithelial-mesenchymal transition (EMT), although their roles in GBC are unclear. We investigated the relationship between the CD44 isoforms with EMT, chemotaxis, and tumorigenicity. We analyzed CD44 expression in the GBC cell line NOZ and found that it comprises a major population that expressed CD44std+/CD44v9- (CD44s) and the minor population that expressed CD44std-/CD44v9+ (CD44v)...
July 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28669660/aga-institute-series-focus-on-enhancing-high-value-care-when-does-assessment-for-bile-duct-stones-need-to-be-performed-prior-to-cholecystectomy-for-calculus-gallbladder-disease
#17
Dennis Yang, Patrick Yachimski
No abstract text is available yet for this article.
June 29, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28669532/intraoperative-cholangiography-during-cholecystectomy-among-hospitalized-medicare-beneficiaries-with-non-neoplastic-biliary-disease
#18
Elizabeth J Lilley, John W Scott, Wei Jiang, Anna Krasnova, Nikhila Raol, Navin Changoor, Ali Salim, Adil H Haider, Joel S Weissman, Eric B Schneider, Zara Cooper
BACKGROUND: Prior studies of Medicare beneficiaries with both neoplastic and non-neoplastic indications for cholecystectomy demonstrated a reduced risk of common bile duct (CBD) injury when intraoperative cholangiography (IOC) was used. We sought to determine the association between IOC and CBD injury during inpatient cholecystectomy for non-neoplastic biliary disease and compare survival among those with or without CBD injury. METHODS: Retrospective study of patients ≥66 who underwent inpatient cholecystectomy (2005-2010) for gallstones, cholecystitis, cholangitis, or gallbladder obstruction...
June 23, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28667672/is-cystic-artery-lymph-node-excision-during-laparoscopic-cholecystectomy-a-marker-of-technique
#19
Arkadiusz P Wysocki, Skyle Murphy, Robert S Ware
BACKGROUND: In order to minimize bile duct injury, experts suggest that dissection during laparoscopic cholecystectomy (LC) should be performed lateral to the lymph node (LN). This study aims to determine whether the frequency of excision of the LN is related to patient factors, disease severity or surgical difficulty. METHODS: All LCs performed or supervised by one surgeon were identified from a prospective database. The presence of LN was retrospectively determined by reviewing the gallbladder histology report...
July 1, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28666456/effect-of-cholecystectomy-on-hepatic-fat-accumulation-and-insulin-resistance-in-non-obese-hispanic-patients-a-pilot-study
#20
Víctor Cortés, Nicolás Quezada, Sergio Uribe, Marco Arrese, Flavio Nervi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Experimental studies have shown that cholecystectomy (XGB) increases hepatic fat content in mice and appears associated to NAFLD in large retrospective population-based studies. The aim of this study was to prospectively assess the effects of XGB on hepatic fat content (HFC) and insulin resistance (IR) in non-obese, middle aged Hispanic subjects. METHODS: Twenty-six gallstone patients undergoing elective XGB and 16 control subjects with normal livers and gallbladders at ultrasonography were prospectively followed 24 months for changes in HFC and IR...
June 30, 2017: Lipids in Health and Disease
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