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Van Hoan Nguyen, Audrey Dubot-Pérès, Fiona M Russell, David A B Dance, Keoudomphone Vilivong, Souphatsone Phommachan, Chanthaphone Syladeth, Jana Lai, Ruth Lim, Melinda Morpeth, Mayfong Mayxay, Paul N Newton, Hervé Richet, Xavier De Lamballerie
The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD(®) kit)...
August 24, 2017: Scientific Reports
Jean-François Longevial, Khaled El Cheikh, Dina Aggad, Aurélien Lebrun, Arie van der Lee, Frederik Tielens, Sébastien Clément, Alain Morère, Marcel Garcia, Magali Gary-Bobo, Sébastien Richeter
Porphyrins fused to imidazolium salts across two neighboring beta-pyrrolic positions were used as N-heterocyclic carbene (NHC) precursors to anchor Au(I)-Cl complexes at their periphery. Then, synthesis of several thiolato-Au(I) complexes was achieved by substituting chloride by thiolates. Photodynamic properties of these complexes were investigated; the data obtained show that the Au-S bonds could be cleaved upon irradiation. The proposed mechanism to explain the release of thiolate moiety involves the S atom oxidation by singlet oxygen generated in the course of irradiation...
August 1, 2017: Chemistry: a European Journal
Yves-Marie Lahaie, Hervé Watier
The history of antimicrobial humoral immunity usually focuses on the works of the German school at the end of the 19th century, born in the tradition of chemistry and disinfection. Starting from an old quarrel of priority about serotherapy between Emil von Behring (1854-1917) and the French physiologists Charles Richet (1850-1935) and Jules Héricourt (1850-1938), we first confirm that the latter stated the principle of serotherapy in 1888 and put it into practice before the seminal Behring's article in 1890, observing several adverse effects of this new immunotherapy...
July 2017: MAbs
Laure Guillotin, Nicolas Richet, Pierre Lafite, Richard Daniellou
Glycoside hydrolases can be turned into thioglycoligase by mutation of the acid/base catalytic carboxylate residue. These mutants have proven valuable to generate S-glycosides, however, few examples in literature have described efficient thioglycoligase activity, and even fewer the underlying molecular mechanism. DtMan, a GH2 family β-d-mannosidase from the thermophilic Dictyoglomus thermophilum was cloned and expressed in E. coli. The recombinant protein is highly specific for β-d-mannosides, and exhibits efficient catalysis constants coupled to thermostability...
June 2017: Biochimie
L Magro, J Gauthier, M Richet, M Robin, S Nguyen, F Suarez, J-H Dalle, T Fagot, A Huynh, M-T Rubio, R Oumadely, S Vigouroux, N Milpied, A Delcampe, I Yakoub-Agha
Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. The aim of this work was to assess the efficacy and tolerability of scleral lenses to treat severe cGvHD-related KCS. In this retrospective, multicenter study, we included 60 consecutive patients diagnosed with cGvHD-related KCS and fitted with scleral lenses. Patients were evaluated at baseline and at 2 months with the following tests: the Ocular Surface Disease Index (OSDI) to assess quality of life, the Oxford score to grade corneal damage and the logarithm of minimal angle of resolution (Log MAR) scale to determine visual acuity...
June 2017: Bone Marrow Transplantation
Donato Belmonte, Carlo Gatti, Giulio Ottonello, Pascal Richet, Marino Vetuschi Zuccolini
Thermodynamic and thermophysical properties of Na2SiO3 in the Cmc21 structural state are computed ab initio using the hybrid B3LYP density functional method. The static properties at the athermal limit are first evaluated through a symmetry-preserving relaxation procedure. The thermodynamic properties that depend on vibrational frequencies, viz., heat capacities, thermal expansion, thermal derivative of the bulk modulus, thermal correction to internal energy, enthalpy, and Gibbs free energy, are then computed in the framework of quasi-harmonic approximation...
November 10, 2016: Journal of Physical Chemistry. A
Sulaf Alwassouf, Carla Maia, Nazli Ayhan, Monica Coimbra, Jose Manuel Cristovao, Herve Richet, Laurence Bichaud, Lenea Campino, Remi N Charrel
Sandfly-borne phleboviruses are endemic in the Mediterranean basin. However, levels of exposure of human and animal populations are inadequately researched. Toscana virus (TOSV) is present in Portugal where it causes human infection and disease; in contrast there are few data for sandfly fever Sicilian virus (SFSV) which has neither been isolated nor detected by molecular tests and for which there are only limited serological data. The sera collected from 1160 dogs and 189 cats in southern Portugal were tested for the presence of neutralizing antibodies against TOSV and SFSV, two viruses recognized as distinct serocomplexes in the Mediterranean region...
November 2016: Journal of General Virology
F Fenollar, P Minodier, A Boutin, R Laporte, V Brémond, G Noël, S Miramont, H Richet, S Benkouiten, J-C Lagier, J Gaudart, J-L Jouve, D Raoult
Tropheryma whipplei was detected in preliminary studies in faeces of young children with diarrhoea and also in faeces of asymptomatic persons, not only in Europe but also in Africa. In this study, the link between this bacterium and the presence of acute diarrhoea was evaluated in a large group of children. From December 2009 to January 2013, rectal swabs collected from 3796 children in the emergency departments of university hospitals in Marseille, France, were analysed: 555 children (245 female and 310 male, from 6 days to 6 years old) with acute diarrhoea defined as at least three loose stools per day for <1 week and 3241 children (1444 female and 1797 male, from 22 days to 6 years old) without diarrhoea...
October 2016: Clinical Microbiology and Infection
María Rodríguez-Castillo, Gustavo Lugo-Preciado, Danielle Laurencin, Frederik Tielens, Arie van der Lee, Sébastien Clément, Yannick Guari, José M López-de-Luzuriaga, Miguel Monge, Françoise Remacle, Sébastien Richeter
The reactivity of benzimidazol-2-ylidenes with respect to gold nanoparticles (AuNPs) has been investigated using a combined experimental and computational approach. First, the grafting of benzimidazol-2-ylidenes bearing benzyl groups on the nitrogen atoms is described, and comparisons are made with structurally similar N-heterocyclic carbenes (NHCs) bearing other N-groups. Similar reactivity was observed for all NHCs, with 1) the erosion of the AuNPs under the effect of the NHC and 2) the formation of bis(NHC) gold complexes...
July 18, 2016: Chemistry: a European Journal
Andrea Graus
In 1888, the spiritist Ercole Chiaia challenged Cesare Lombroso to go to Naples and study a brilliant though still unknown medium: Eusapia Palladino. At that time Lombroso turned down the challenge. However, in 1891 he became fascinated by the medium's phenomena. Despite the abundant literature on Palladino, there is still an episode that needs to be explored: in 1888, the Spanish doctor Manuel Otero Acevedo accepted the challenge rejected by Lombroso, spent three months in Naples studying the medium and invited the Italian psychiatrist to join his investigations...
July 2016: Journal of the History of the Behavioral Sciences
Emmanouil Angelakis, Herve Richet, Didier Raoult
To further characterize human infections caused by Rickettsia sibirica mongolitimonae, we tested skin biopsy and swab samples and analyzed clinical, epidemiologic, and diagnostic characteristics of patients with a rickettsiosis. The most common (38%) indigenous species was R. sibirica mongolitimonae. Significantly more cases of R. sibirica mongolitimonae infection occurred during spring and summer.
May 2016: Emerging Infectious Diseases
Mathieu Nivon, Loïc Fort, Pascale Muller, Emma Richet, Stéphanie Simon, Baptiste Guey, Maëlenn Fournier, André-Patrick Arrigo, Claudio Hetz, Julie D Atkin, Carole Kretz-Remy
During cell life, proteins often misfold, depending on particular mutations or environmental changes, which may lead to protein aggregates that are toxic for the cell. Such protein aggregates are the root cause of numerous diseases called "protein conformational diseases," such as myofibrillar myopathy and familial amyotrophic lateral sclerosis. To fight against aggregates, cells are equipped with protein quality control mechanisms. Here we report that NFκB transcription factor is activated by misincorporation of amino acid analogues into proteins, inhibition of proteasomal activity, expression of the R120G mutated form of HspB5 (associated with myofibrillar myopathy), or expression of the G985R and G93A mutated forms of superoxide dismutase 1 (linked to familial amyotrophic lateral sclerosis)...
June 1, 2016: Molecular Biology of the Cell
Raymond Ardaillou, Pierre Ronco
Gabriel Richet who died in Paris in October 2014 was the fourth of a brilliant dynasty of professors of medicine including a Nobel prize, his grandfather, Charles Richet. He behaved courageously during the Second World War and participated in the Campaign of France in 1940 and in the combats in the Vosges Mountains in 1945. His family participated in the resistance during the German occupation of France and three of his parents including his father, one of his brothers and one of his cousins were deported in Germany...
February 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Pierre Legrand, Barry Collins, Stéphanie Blangy, James Murphy, Silvia Spinelli, Carlos Gutierrez, Nicolas Richet, Christine Kellenberger, Aline Desmyter, Jennifer Mahony, Douwe van Sinderen, Christian Cambillau
UNLABELLED: The Gram-positive bacterium Lactococcus lactis, used for the production of cheeses and other fermented dairy products, falls victim frequently to fortuitous infection by tailed phages. The accompanying risk of dairy fermentation failures in industrial facilities has prompted in-depth investigations of these phages. Lactococcal phage Tuc2009 possesses extensive genomic homology to phage TP901-1. However, striking differences in the baseplate-encoding genes stimulated our interest in solving the structure of this host's adhesion device...
January 26, 2016: MBio
Michèle Chevrier, Sébastien Richeter, Olivier Coulembier, Mathieu Surin, Ahmad Mehdi, Roberto Lazzaroni, Rachel C Evans, Philippe Dubois, Sébastien Clément
Poly(3-hexylthiophene)s end-functionalized with π-extended porphyrins have been synthesized in a one-pot procedure. The polymers show a broad absorption profile extending to 700 nm and a fibrillar microstructure, which can be tuned through judicious selection of the porphyrin molar ratio.
January 4, 2016: Chemical Communications: Chem Comm
S Hansen, F Schwab, P Gastmeier, D Pittet, W Zingg, H Sax, P Gastmeier, S Hansen, H Grundmann, B van Benthem, T van der Kooi, M Dettenkofer, M Martin, H Richet, E Szilágyi, O E Központ, P B Heczko, A Holmes, Y Kyratsis, R Ahmad, B Allegranzi, A Magiorakos, B Cookson, A W Wu
Hand hygiene is considered to be the most effective way of preventing microbial transmission and healthcare-associated infections. The use of alcohol-based hand rubs (AHRs) is the reference standard for effective hand hygiene. AHR consumption is a valuable surrogate parameter for hand hygiene performance, and it can be easily tracked in the healthcare setting. AHR availability at the point of care ensures access to optimal agents, and makes hand hygiene easier by overcoming barriers such as lack of AHRs or inconvenient dispenser locations...
December 2015: Clinical Microbiology and Infection
Nadim Cassir, Silvestre De La Rosa, Anthony Melot, Adamou Touta, Lucas Troude, Anderson Loundou, Hervé Richet, Pierre-Hugues Roche
BACKGROUND: Surgical site infection (SSI) after neurosurgery has potentially devastating consequences. METHODS: A prospective cohort study was conducted over a period of 24 months in a university center. All adult patients undergoing neurosurgical procedures, with exception of open skull fractures, were included. Multivariate logistic regression analysis was used to identify independent risk factors. RESULTS: We included 949 patients. Among them, 43 were diagnosed with SSI (4...
December 1, 2015: American Journal of Infection Control
Xavier Fritel, Renaud de Tayrac, Georges Bader, Denis Savary, Ameth Gueye, Xavier Deffieux, Hervé Fernandez, Claude Richet, Joëlle Guilhot, Arnaud Fauconnier
OBJECTIVE: To compare, in an unselected population of nulliparous pregnant women, the postnatal effect of prenatal supervised pelvic floor muscle training with written instructions on postpartum urinary incontinence (UI). METHODS: In a randomized controlled trial in two parallel groups, 282 women were recruited from five university teaching hospitals in France and randomized during the second trimester of pregnancy. The physiotherapy group received prenatal individually supervised exercises...
August 2015: Obstetrics and Gynecology
Jenifer Rubio-Magnieto, Elias Gebremedhn Azene, Jérémie Knoops, Stefan Knippenberg, Cécile Delcourt, Amandine Thomas, Sébastien Richeter, Ahmad Mehdi, Philippe Dubois, Roberto Lazzaroni, David Beljonne, Sébastien Clément, Mathieu Surin
The combination of DNA and π-conjugated polyelectrolytes (CPEs) represents a promising approach to develop DNA hybridization biosensors, with potential applications for instance in the detection of DNA lesions and single-nucleotide polymorphisms. Here we exploit the remarkable optical properties of a cationic poly[3-(6'-(trimethylphosphonium)hexyl)thiophene-2,5-diyl] (CPT) to decipher the self-assembly of DNA and CPT. The ssDNA/CPT complexes have chiroptical signatures in the CPT absorption region that are strongly dependent on the DNA sequence, which we relate to differences in supramolecular interactions between the thiophene monomers and the various nucleobases...
August 28, 2015: Soft Matter
Mélanie Mauriat, Jean-Charles Leplé, Stéphane Claverol, Jérôme Bartholomé, Luc Negroni, Nicolas Richet, Céline Lalanne, Marc Bonneu, Catherine Coutand, Christophe Plomion
Trees adjust their growth following forced changes in orientation to re-establish a vertical position. In angiosperms, this adjustment involves the differential regulation of vascular cambial activity between the lower (opposite wood) and upper (tension wood) sides of the leaning stem. We investigated the molecular mechanisms leading to the formation of differential wood types through a quantitative proteomic and phosphoproteomic analysis on poplar subjected to a gravitropic stimulus. We identified and quantified 675 phosphopeptides, corresponding to 468 phosphoproteins, and 3 763 nonphosphorylated peptides, corresponding to 1 155 proteins, in the differentiating xylem of straight-growing trees (control) and trees subjected to a gravitational stimulus during 8 weeks...
August 7, 2015: Journal of Proteome Research
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