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https://www.readbyqxmd.com/read/29150094/-geriatric-assessment-and-prognostic-scores-in-older-cancer-patient-additional-support-to-the-therapeutic-decision
#1
REVIEW
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29075972/clinical-benefits-of-single-incision-laparoscopic-surgery-for-postoperative-delirium-in-elderly-colon-cancer-patients
#2
Yujiro Nishizawa, Taishi Hata, Ichiro Takemasa, Makoto Yamasaki, Hiroshi Akasaka, Ken Sugimoto, Koki Tamai, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Chu Matsuda, Tsunekazu Mizushima, Masakazu Ikenaga, Hirofumi Yamamoto, Kohei Murata, Hiromi Rakugi, Yuichiro Doki, Masaki Mori
BACKGROUND: The number of elderly patients with colon cancer is increasing in Japan. Postoperative delirium (POD) is a major complication for elderly patients who undergo surgery, and postoperative pain is a common inducer of POD. We reported previously that single-incision laparoscopic surgery (SLS) significantly reduces postoperative pain compared to conventional laparoscopic surgery (CLS). Data are lacking about the effect of SLS on POD. This retrospective study evaluated the clinical benefits of SLS for POD in elderly patients with colon cancer...
October 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29068978/treatment-prognostic-markers-and-survival-in-thymic-neuroendocrine-tumors-a-single-center-experience-of-41-patients
#3
Kefeng Ma, Yi Liu, Zhiqiang Xue, Xiangyang Chu
Neuroendocrine tumors of the thymus (NETTs) are rare but aggressive, and lead to poor overall survival. This retrospective study was designed to analyze factors that correlate with the prognosis of patients with NETTs.From 1999 to 2015, 41 ongoing patients with NETTs were enrolled in this study. The clinical data and outcome were compiled. Overall survival (OS) rate was analyzed using the Kaplan-Meier method in univariate analysis and the Cox-model was used in multivariate analysis.Of the 41 NETTs patients analyzed (31 male and 10 female), 12 were typical carcinoma, 14 were atypical carcinoma, 14 were small-cell carcinoma and, 1 was large-cell carcinoma...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29063810/the-use-of-uhear%C3%A2-to-screen-for-hearing-loss-in-older-patients-with-cancer-as-part-of-a-comprehensive-geriatric-assessment
#4
Michelle Lycke, Philip R Debruyne, Tessa Lefebvre, Evi Martens, Lore Ketelaars, Hans Pottel, Koen Van Eygen, Sofie Derijcke, Patrick Werbrouck, Philippe Vergauwe, Karin Stellamans, Philippe Clarysse, Ingeborg Dhooge, Patricia Schofield, Tom Boterberg
OBJECTIVE: We previously validated uHear™ to screen for hearing loss in older patients with cancer without a known hearing loss, as part of a comprehensive geriatric assessment (CGA). In view of low specificity, we tested a new modified uHear™ scoring system as described by Handzel. METHODS: Patients, aged ≥70 years, were evaluated by uHear™ and conventional audiometry, which is considered the gold standard, as part of a CGA. The pass or fail screening cut-off for uHear™ was defined as having ≥2 consecutive hearing grades starting from the moderate-severe threshold zone ranging from 0...
October 24, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29054805/factors-predicting-adherence-to-a-tailored-dose-adjuvant-treatment-on-the-basis-of-geriatric-assessment-in-elderly-people-with-colorectal-cancer-a-prospective-study
#5
Maite Antonio, Alberto Carmona-Bayonas, Juana Saldaña, Valentí Navarro, Cristian Tebé, Ramon Salazar, Josep Maria Borràs
BACKGROUND: Selecting elderly people with colorectal cancer (CRC) for adjuvant chemotherapy is challenging. Comprehensive geriatric assessment (CGA) can help by classifying them according to their frailty profile. The supposed benefit of chemotherapy is on the basis of the rate of treatment adherence. In this study we evaluated tolerance and adherence to tailored-dose adjuvant therapy on the basis of CGA in a cohort of older patients with high-risk stage II and stage III CRC. PATIENTS AND METHODS: This was a prospective study in 193 consecutive patients aged 75 years or older...
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28980157/expression-of-the-cholecystokinin-b-receptor-in-neoplastic-gastric-cells
#6
Patricia Mjønes, Ivar S Nordrum, Øystein Sørdal, Liv Sagatun, Reidar Fossmark, Arne Sandvik, Helge L Waldum
Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus, cholecystokinin-B receptor (CCKBR) becomes of interest. The aim of our study was to explore whether CCKBR is expressed in stomach cancers. Thirty-seven tumors from 19 men and 18 women diagnosed with either adenocarcinoma or neuroendocrine neoplasm (NENs) were included in this study...
October 4, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28958666/pearls-of-optimizing-nutrition-and-physical-performance-of-older-adults-undergoing-cancer-therapy
#7
Antonio Vigano, Popi Kasvis, Jonathan Di Tomasso, Chelsia Gillis, Robert Kilgour, Franco Carli
As the global population continues to age, the prevalence of cancer is increasing, with more than half of new cancer diagnoses occurring in those aged 65years and older. As a result of improved oncological care, a greater number of older patients undergo treatment, either chemoradiotherapy or surgery or both. The older oncology patient is not part of a homogenous group; chronological age poorly describes the health status of an individual. Comprehensive geriatric assessment (CGA) identifies domains, assessed by a multidisciplinary team, that should be considered to guide appropriate oncological treatment decisions...
November 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28927761/comprehensive-geriatric-assessment-and-caring-for-the-older-person-with-cancer
#8
REVIEW
Janine Overcash, Mary Alice Momeyer
OBJECTIVES: To discuss the evolution and effectiveness of the comprehensive geriatric assessment (CGA), the need for interprofessional collaboration, and the role of oncology nurses in the assessment and care coordination of the older patient with cancer. DATA SOURCES: Historical and recent publications. CONCLUSION: Oncology nurses collect and synthesize geriatric data and can be a central resource to the multidisciplinary team. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses can incorporate CGA and results into their practice to enhance the care of the older person...
November 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28890334/crispr-mediated-base-editing-enables-efficient-disruption-of-eukaryotic-genes-through-induction-of-stop-codons
#9
Pierre Billon, Eric E Bryant, Sarah A Joseph, Tarun S Nambiar, Samuel B Hayward, Rodney Rothstein, Alberto Ciccia
Standard CRISPR-mediated gene disruption strategies rely on Cas9-induced DNA double-strand breaks (DSBs). Here, we show that CRISPR-dependent base editing efficiently inactivates genes by precisely converting four codons (CAA, CAG, CGA, and TGG) into STOP codons without DSB formation. To facilitate gene inactivation by induction of STOP codons (iSTOP), we provide access to a database of over 3.4 million single guide RNAs (sgRNAs) for iSTOP (sgSTOPs) targeting 97%-99% of genes in eight eukaryotic species, and we describe a restriction fragment length polymorphism (RFLP) assay that allows the rapid detection of iSTOP-mediated editing in cell populations and clones...
September 21, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28870943/prospective-evaluation-of-neuromediator-dynamics-in-castration-resistant-prostate-cancer-patients-during-docetaxel
#10
MULTICENTER STUDY
Jost VON Hardenberg, Maike Schwartz, Thorsten Werner, Stefan Fuxius, Markus Müller, Thomas Frangenheim, Christian Bolenz, Christel Weiss, Elmar Heinrich
AIM: Aim of the study was to detect small cell/neuroendocrine (SCNC) transformation in metastatic castration-resistant prostate cancer (mCRPC) that is a challenging procedure. We investigated the role of neuromediator dynamics as potential evidence of SCNC in patients undergoing docetaxel therapy. PATIENTS AND METHODS: A multi-institutional, prospective observational study was conducted. Patients undergoing docetaxel treatment were included. Chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin releasing peptide (Pro-GRP) were sequentially evaluated at predefined time points...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28853910/coffee-consumption-and-disease-correlations
#11
Büşra Başar Gökcen, Nevin Şanlier
Coffee is one of the most widely consumed beverages in the world. It has primarily consumed due to its stimulant effect and unique taste since the ancient times. Afterwards, its consumption has been historically associated with a lower risk of some diseases such as type 2 diabetes mellitus, obesity, cardiovascular disease and some type of cancer and thus it has also consumed due to health benefits. It contains many bioactive compounds such as caffeine, chlorogenic acids and diterpenoid alcohols which have so far been associated with many potential health benefits...
August 30, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28804908/influence-of-abiraterone-acetate-on-neuroendocrine-differentiation-in-chemotherapy-naive-metastatic-castration-resistant-prostate-cancer
#12
Baijun Dong, Liancheng Fan, Yanqing Wang, Chenfei Chi, Xiaowei Ma, Rui Wang, Wen Cai, Xiaoguang Shao, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Xiaonan Kang, Lixin Zhou, Wei Xue
BACKGROUND: To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted an analysis in 115 chemotherapy-naïve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone-specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment...
May 2017: Prostate
https://www.readbyqxmd.com/read/28797032/comprehensive-geriatric-assessment-in-326-older-women-with-early-breast-cancer
#13
MULTICENTER STUDY
D O Okonji, R Sinha, I Phillips, D Fatz, A Ring
BACKGROUND: One-third of new early breast cancer diagnoses occur in women over 70 years old. However, older women are less likely to receive radical curative treatments. This study prospectively evaluated a cohort of older women using a Comprehensive Geriatric Assessment (CGA) to determine whether fitness explained the apparent under-treatment in this patient group. METHODS: In this multi-centre prospective study, patients aged ⩾70 years with Stages I-III breast cancer underwent a pretreatment baseline CGA consisting of eight assessment tools...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28738329/distinct-involvement-of-the-sonic-hedgehog-signaling-pathway-in-gastric-adenocarcinoma-of-fundic-gland-type-and-conventional-gastric-adenocarcinoma
#14
Yuzuru Tajima, Takashi Murakami, Tsuyoshi Saito, Takafumi Hiromoto, Yoichi Akazawa, Noriko Sasahara, Hiroyuki Mitomi, Takashi Yao, Sumio Watanabe
BACKGROUND/AIMS: Gastric adenocarcinoma of fundic gland type (GAFG), which is a rare variant of gastric cancer, is reportedly associated with both Wnt/β-catenin signaling activation and guanine nucleotide binding protein, alpha stimulating complex (GNAS) mutations. This study aimed to elucidate potential roles of the Sonic hedgehog (Shh) signaling pathway in GAFG. METHODS: We performed immunostaining for β-catenin and Shh signal-associated proteins, including Patched (Ptch), Smoothened (Smo), and Glioma-associated oncogene-1 (Gli1), and the direct sequencing of GNAS/BRAF/KRAS in 27 GAFGs, and compared them with 30 conventional gastric adenocarcinomas (CGAs)...
2017: Digestion
https://www.readbyqxmd.com/read/28719146/natural-compounds-in-cancer-prevention-effects-of-coffee-extracts-and-their-main-polyphenolic-component-5-o-caffeoylquinic-acid-on-oncogenic-ras-proteins
#15
Alessandro Palmioli, Carlotta Ciaramelli, Renata Tisi, Michela Spinelli, Gaia De Sanctis, Elena Sacco, Cristina Airoldi
Recent epidemiological studies have demonstrated that the consumption of healthy foods that are particularly rich in polyphenols might reduce the incidence of cancer and neurodegenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiquitously in food and represent the most abundant polyphenols in the human diet. A number of beneficial biological effects of CGAs, such as anti-inflammatory activity, anti-carcinogenic activity, and protection against neurodegenerative diseases, have been reported...
July 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28688872/paraganglioma-of-the-urinary-bladder-a-series-of-22-cases-in-a-single-center
#16
Hongyun Zhai, Xin Ma, Wenyuan Nie, Hongzhao Li, Cheng Peng, Xintao Li, Yu Zhang, Xu Zhang
OBJECTIVE: Paraganglioma of the urinary bladder (PUB) is rare in bladder cancer, and currently, a study examining large number of cases from a single center has not been reported. This study aimed to present the clinical features, treatments, pathological characteristics, and prognosis of PUB. PATIENTS AND METHODS: From January 2006 to June 2016, 22 patients were pathologically diagnosed with PUB in our hospital. Their clinical records, operative notes, pathological reports, and follow-up records were retrospectively reviewed...
March 28, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28659138/the-effect-of-geriatric-intervention-in-frail-elderly-patients-receiving-chemotherapy-for-colorectal-cancer-a-randomized-trial-gerico
#17
C M Lund, K K Vistisen, C Dehlendorff, F Rønholt, J S Johansen, D L Nielsen
BACKGROUND: Better surgical techniques, chemotherapy and biological therapy have improved survival in patients with colorectal cancer (CRC), most markedly in younger patients. About half of patients over 70 years receive dose reductions or early treatment discontinuation of the planned adjuvant or first-line treatment due to side effects. The Comprehensive Geriatric Assessment (CGA) is a multidisciplinary evaluation of an elderly individual's health status. This assessment in older patients with cancer can predict survival, chemotherapy toxicity and morbidity...
June 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28592379/comprehensive-geriatric-assessment-in-men-aged-70-years-or-older-with-localised-prostate-cancer-undergoing-radical-radiotherapy
#18
G E C Osborne, S A Appleyard, D C Gilbert, C I Jones, C Lorimer, M Villanueva, E Peasgood, A Robinson, A Nikapota, A Ring
AIMS: Treatment decisions for men aged 70 years or over with localised prostate cancer need to take into account the risk of death from competing causes and fitness for the proposed treatment. Objective assessments such as those included in a comprehensive geriatric assessment (CGA) might help to inform the decision-making process. The aim of this study was to describe the CGA scores of a cohort of older men with prostate cancer, evaluate potential screening tools in this population and assess whether any CGA component predicts significant acute radiotherapy toxicity...
September 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28585679/diagnostic-value-of-selected-biochemical-markers-in-the-detection-of-recurrence-of-medullary-thyroid-cancer-comparison-of-calcitonin-procalcitonin-chromogranin-a-and-carcinoembryonic-antigen
#19
Kosma Woliński, Jarosław Kaznowski, Aleksandra Klimowicz, Adam Maciejewski, Dagny Łapińska-Cwojdzińska, Edyta Gurgul, Adrian D Car, Marta Fichna, Paweł Gut, Maria Gryczyńska, Marek Ruchała
INTRODUCTION: Medullary thyroid cancer (MTC) is a malignancy of the thyroid gland, which derives from parafollicular C cells. Periodic measurement of biochemical markers of MTC remains a crucial part of patient follow-up and disease monitoring. The aim of the study was to compare the diagnostic value of four selected markers - calcitonin (Ct), procalcitonin (PCT), chromogranin A (CgA), and carcinoembryonic antigen (CEA). METHODS: Patients with histopathologically confirmed MTC hospitalised in a single department between January 2015 and December 2015 were included in the study...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28578586/origin-of-somatic-mutations-in-%C3%AE-catenin-versus-adenomatous-polyposis-coli-in-colon-cancer-random-mutagenesis-in-animal-models-versus-nonrandom-mutagenesis-in-humans
#20
REVIEW
Da Yang, Min Zhang, Barry Gold
Wnt signaling is compromised early in the development of human colorectal cancer (CRC) due to truncating nonsense mutations in adenomatous polyposis coli (APC). CRC induced by chemical carcinogens, such as heterocyclic aromatic amines and azoxymethane, in mice also involves dysregulation of Wnt signaling but via activating missense mutations in the β-catenin oncogene despite the fact that genetically modified mice harboring an inactive APC allele efficiently develop CRC. In contrast, activating mutations in β-catenin are rarely observed in human CRC...
July 17, 2017: Chemical Research in Toxicology
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