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Multiple Scelerosis

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https://www.readbyqxmd.com/read/27400972/a-central-role-for-atp-signaling-in-glial-interactions-in-the-cns
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Andrea Rivera, Ilaria Vanzulli, Arthur M Butt
The purine ATP has a prominent regulatory role in CNS function and pathology due to its actions on glial cells - microglia, astrocytes and oligodendrocytes. ATP serves as a ubiquitous 'gliotransmitter' that is released by astrocytes to activate purine receptors on neighbouring cells. In pathology, ATP release from glia and damaged cells mediates both tissue destruction and repair. The actions of ATP on glia are mediated via a wide range of receptors, broadly divided into ionotropic P2X and metabotropic (G-protein coupled receptors (GPCR) P2Y receptors, of which there are multiple subtypes (P2X1-P2X7 and P2Y1-P2Y14)...
July 11, 2016: Current Drug Targets
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