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https://www.readbyqxmd.com/read/29792935/lp533401-restores-bone-health-in-5-6-nephrectomized-rats-by-a-decrease-of-gut-derived-serotonin-and-regulation-of-serum-phosphate-through-the-inhibition-of-phosphate-co-transporters-expression-in-the-kidneys
#1
Dariusz Pawlak, Beata Znorko, Bartlomiej Kalaska, Tomasz Domaniewski, Radosław Zawadzki, Paweł Lipowicz, Michał Doroszko, Urszula Łebkowska, Piotr Grabowski, Krystyna Pawlak
LP533401 is an orally bioavailable small molecule that inhibits tryptophan hydroxylase-1, an enzyme responsible for the synthesis of gut-derived serotonin (GDS). Recently, we showed that increased GDS in rats with chronic kidney disease (CKD) affected bone strength and metabolism. We tested the hypothesis that treatment with LP533401 could reverse CKD-induced bone loss in uremia. Sixteen weeks after 5/6 nephrectomy, rats were randomized into untreated (CKD), treated with vehicle (VEH) and LP533401 at a dose of 30 or 100 mg/kg daily for 8 weeks...
May 21, 2018: Bone
https://www.readbyqxmd.com/read/29792728/single-acquisition-triple-bolus-dual-energy-ct-protocol-for-comprehensive-evaluation-of-renal-masses-a-single-center-randomized-noninferiority-trial
#2
Dinesh Manoharan, Sanjay Sharma, Chandan J Das, Rajeev Kumar, Geetika Singh, Pratik Kumar
OBJECTIVE: The primary objective of this study was to compare triple-bolus dual-energy CT (DECT) against standard triple-phase MDCT in terms of appropriateness of patient treatment. SUBJECTS AND METHODS: One hundred twenty-four patients with suspected renal masses seen at ultrasound were randomized into triple-bolus DECT and triple-phase MDCT groups. Patients in the triple-bolus DECT group underwent synchronous corticomedullary nephrographic delayed-phase triple-bolus DECT...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792370/efficacy-and-safety-of-intravenous-belimumab-in-japanese-patients-with-systemic-lupus-erythematosus-a-subgroup-analysis-of-a-phase-3-randomized-placebo-controlled-trial
#3
Yoshiya Tanaka, Damon Bass, Myron Chu, Sally Egginton, Beulah Ji, Herbert Struemper, David Roth
OBJECTIVES: To assess the efficacy and safety of intravenous belimumab plus standard systemic lupus erythematosus (SLE) therapy (SoC) in Japanese patients with SLE. METHODS: A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, randomized 2:1 to belimumab 10 mg/kg plus SoC or placebo plus SoC to Week 48. RESULTS: Sixty of 707 randomized patients were enrolled from study centers in Japan (belimumab, n = 39; placebo, n = 21)...
May 24, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29792125/characteristics-of-apixaban-treated-patients-evaluation-of-the-dose-prescribed-and-the-persistence-of-treatment-a-cohort-study-in-catalonia
#4
Ainhoa Gomez-Lumbreras, Jordi Cortes, Maria Giner-Soriano, M Angeles Quijada-Manuitt, Rosa Morros
BACKGROUND: Apixaban is a direct oral anticoagulant, which inhibits factor Xa. It has demonstrated clinical efficacy in prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation and a better safety profile compared to warfarin. OBJECTIVES: (1) To describe the characteristics of patients with nonvalvular atrial fibrillation beginning treatment with apixaban, (2) to analyze concomitant prescriptions of medications that could potentially interact with apixaban, (3) to evaluate the level of appropriate usage according to the recommended dosage, and (4) to estimate the level of apixaban persistence among naive and non-naive patients...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29791921/does-gastroplus-support-similarity-and-dissimilarity-factors-of-in-vitro-in-vivo-prediction-in-biowaiver-studies-a-lower-strength-amlodipine-as-a-model-drug
#5
Abdel Naser Zaid, Naser Shraim, Asmaa Radwan, Nidal Jaradat, Samah Hirzallah, Ibrahim Issa, Aya Khraim
BACKGROUND: Many generic pharmaceutical products are currently available on the market place worldwide. Recently, there is a growing concern on the quality and efficacy of generic products. However, health care professionals such as physicians and pharmacists are in difficult situations to choose among alternatives. PURPOSE: The aim of this study is to assess the effectiveness of the in silico technique (Gastro Plus® ) in the biowaiver study and whether similarity and dissimilarity factors ( f 2 and f 1 respectively) are effective in this regard...
May 23, 2018: Drug Research
https://www.readbyqxmd.com/read/29791917/hybrid-diffuse-reflectance-spectroscopy-non-erythemal-in-vivo-testing-of-sun-protection-factor
#6
Mathias Rohr, Nikolai Ernst, Andreas Schrader
BACKGROUND/AIMS: In order to define a label sun protection factor (SPF) of topically applied sunscreens, in vivo test methods like ISO 24444, FDA guideline, or the Australian standard are used worldwide. The basis of all these methods is provoking an erythemal skin reaction by UV irradiation to find the level of unprotected and protected minimal erythemal doses (MED). In vitro methods replacing the human skin by any kind of non-human material are still not available. Thus, offering the new hybrid diffuse reflectance spectroscopy (HDRS) technique that is able to stay on an in vivo level for SPF testing but meanwhile neglecting the UV-dose-related erythemal skin reaction is a perfect combination to take care of sun protection and any ethical concerns in SPF testing nowadays...
May 23, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29791314/analgesic-anti-inflammatory-and-anti-arthritic-properties-of-aqueous-and-methanolic-stem-bark-extracts-from-nauclea-pobeguinii-rubiacee-in-rats
#7
Mbiantcha Marius, Tsafack Eric Gonzal, Ateufack Gilbert, Nana Yousseu William, Bomba Tatsinkou Francis Désiré, Djuichou Nguemnang Stephanie Flore, Mbankou Ngassam Sorelle, Wego Kamgaing Marius Tresor
Background Nauclea pobeguinii is a plant species found in the centre region of Cameroon. The stem bark of this plant is traditionally used to ease pain and cure inflammation. Method This study was undertaken to evaluate the effects of doses 150 and 300 mg/kg of the aqueous and methanolic stem bark extracts from Nauclea pobeguinii on acute pain, acute and chronic inflammation induced by formalin and arthritis induced by zymosan A in rats. Oxidative stress parameters such as catalase, malondialdehyde and nitric oxide were measured in rats subjected to chronic inflammation...
May 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29791260/assessment-of-the-power-required-for-optimal-use-of-current-inhalation-devices
#8
Gerhard Pohlmann, Jens M Hohlfeld, Peter Haidl, Jelena Pankalla, Rolf Michael Cloes
BACKGROUND: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a clear overview on performance requirements of standard inhalation devices that should be met by the patient's breathing power and to develop a new method to measure the individual performance data. MATERIALS AND METHODS: An optimum and still acceptable required breathing power (P in watts) was calculated for each device with the aid of individual device flow rates (determined by a literature search) and the flow resistances (by measuring the pressure drop over the different inhalation devices)...
May 23, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29791199/localization-of-the-inferior-alveolar-canal-using-ultralow-dose-ct-with-iterative-reconstruction-techniques
#9
Asma'a Abdulrahman Al-Ekrish, Wafa Alfaleh, Romed Hörmann, Ameera Alabdulwahid, Wolfgang Puelacher, Gerlig Widmann
OBJECTIVES: To compare subjective and objective localization of the inferior alveolar canal (IAC) on multidetector computed tomography (MDCT) images obtained by ultralow doses in combination with the reconstruction techniques of filtered backprojection (FBP), Adaptive Statistical Iterative Reconstruction (ASIR), or Model Based Iterative Reconstruction (MBIR) as compared to standard dose MDCT and FBP. METHODS: Three cadavers were imaged with a reference standard dose MDCT examination (CTDIvol: 29...
May 23, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29791046/impact-of-intensive-dosing-of-mycophenolate-on-pancreas-allograft-survival
#10
Jillian L Descourouez, Margaret Jorgenson, Nathan Menninga, Glen Leverson, Jon Odorico, Robert Redfield
PURPOSE: Evaluate the effect of mycophenolate (mycophenolic acid, MPA) dose on pancreas allograft survival following simultaneous pancreas kidney (SPK) transplant. METHODS: This was an observational study of adult SPK recipients transplanted between 1/1/2002-6/30/2015. Recipients were divided into cohorts based on MPA dose at discharge; high dose (HD) 1000mg three times daily mycophenolate mofetil (MMF) and standard dose (SD) 1000mg twice daily MMF. Primary outcome was pancreas allograft survival...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29790859/neutron-track-length-estimator-for-gate-monte-carlo-dose-calculation-in-radiotherapy
#11
Halima Elazhar, Thomas Deschler, Jean Michel Letang, Abdelmjid Nourreddine, Nicolas Arbor
The out-of-field dose in radiation therapy is a growing concern in regards to the late side-effects and secondary cancer induction. In high-energy X-ray therapy, the secondary neutrons generated through photonuclear reactions in the accelerator are part of this secondary dose. The neutron dose is currently not estimated by the treatment planning system (TPS) while it appears to be preponderant for distances greater than 50~cm from the isocenter. Monte Carlo (MC) simulation has become the gold standard for accurately calculating the neutron dose under specific treatment conditions but the method is also known for having a slow statistical convergence, which makes it difficult to be used on a clinical basis...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29790820/towards-quantitative-18f-fdg-pet-mri-of-the-brain-automated-mr-driven-calculation-of-an-image-derived-input-function-for-the-non-invasive-determination-of-cerebral-glucose-metabolic-rates
#12
Lalith Ks Sundar, Otto Muzik, Lucas Rischka, Andreas Hahn, Ivo Rausch, Rupert Lanzenberger, Marius Hienert, Eva-Maria Klebermass, Frank-Günther Füchsel, Marcus Hacker, Magdalena Pilz, Ekaterina Pataraia, Tatjana Traub-Weidinger, Thomas Beyer
Absolute quantification of PET brain imaging requires the measurement of an arterial input function (AIF), typically obtained invasively via an arterial cannulation. We present an approach to automatically calculate an image-derived input function (IDIF) and cerebral metabolic rates of glucose (CMRGlc) from the [18F]FDG PET data using an integrated PET/MRI system. Ten healthy controls underwent test-retest dynamic [18F]FDG-PET/MRI examinations. The imaging protocol consisted of a 60-min PET list-mode acquisition together with a time-of-flight MR angiography scan for segmenting the carotid arteries and intermittent MR navigators to monitor subject movement...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29790278/the-split-dose-4-l-polyethylene-glycol-regimen-for-patients-with-previous-colorectal-surgery-in-bowel-preparation-before-colonoscopy-a-randomized-controlled-single-blind-study
#13
Zhu Liu, Yue-Yue Li, Xue-Ting Luo, Chuan-Guo Guo, Ming-Ming Zhang, Zhen Li, Li-Xiang Li, Yan Zhang, Yan-Qing Li
AIM: In some Asian countries, guidelines recommend 2-L polyethylene glycol (PEG) without any additions as the standard bowel preparation (BP) regimen before colonoscopy, which is not sufficient for patients with previous colorectal surgery. The objective of this study was to investigate the efficacy of the split-dose 4-L PEG regimen on the quality of BP in Asian patients with previous colorectal surgery. METHODS: This was a single-center, prospective, randomized-controlled, endoscopist-blinded study...
May 22, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29790263/herbicide-hormesis-can-act-as-a-driver-of-resistance-evolution-in-weeds-ps-ii-target-site-resistance-in-chenopodium-album-l-as-a-case-study
#14
Regina G Belz
BACKGROUND: Herbicide hormesis may play a role in weed resistance evolution by increasing resistance selection. A standard herbicide rate may be subtoxic to resistant plants and make them more fit than untreated plants. If this increase in fitness is ultimately expressed in reproductive traits, resistance genes can accumulate more rapidly and exacerbate resistance evolution by magnifying the selection differential between resistant and sensitive plants. The hypothesis of hormetically enhanced reproductive fitness was studied for a PSII target-site resistant (TSR) biotype of Chenopodium album exposed to the triazinone metamitron in comparison to its wild type...
May 23, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29789994/performance-evaluation-of-a-semi-automated-method-for-18-f-fdg-uptake-in-abdominal-visceral-adipose-tissue
#15
Stefanie A de Boer, Daan S Spoor, Riemer H J A Slart, Douwe J Mulder, Melanie Reijrink, Ronald J H Borra, Gerbrand M Kramer, Otto S Hoekstra, Ronald Boellaard, Marcel J Greuter
PURPOSE: Severity of abdominal obesity and possibly levels of metabolic activity of abdominal visceral adipose tissue (VAT) are associated with an increased risk for cardiovascular disease (CVD). In this context, the purpose of the current study was to evaluate the reproducibility and repeatability of a semi-automated method for assessment of the metabolic activity of VAT using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT)...
May 22, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29789934/induction-prednisone-dosing-for-childhood-nephrotic-syndrome-how-low-should-we-go
#16
Matthew Sibley, Abishek Roshan, Alanoud Alshami, Marisa Catapang, Jasper J Jöbsis, Trevor Kwok, Nonnie Polderman, Jennifer Sibley, Douglas G Matsell, Cherry Mammen
BACKGROUND: Historically, children with nephrotic syndrome (NS) across British Columbia (BC), Canada have been cared for without formal standardization of induction prednisone dosing. We hypothesized that local historical practice variation in induction dosing was wide and that children treated with lower doses had worse relapsing outcomes. METHODS: This retrospective cohort study included 92 NS patients from BC Children's Hospital (1990-2010). We excluded secondary causes of NS, age < 1 year at diagnosis, steroid resistance, and incomplete induction due to early relapse...
May 22, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29789899/-review-of-clinical-trials-in-retinopathy-of-prematurity-current-state-and-future-perspectives
#17
REVIEW
Andreas Stahl
BACKGROUND: The treatment of retinopathy of prematurity (ROP) has gained a new dynamic since the introduction of anti-vascular endothelial growth factor (VEGF) therapy. This review summarizes clinical trial data in order to aid informed decision-making. METHODS: In this article, pivotal clinical trials are summarized and discussed with regard to their implications for ROP therapy. RESULTS: The longest follow-up phase exists for children treated in the CRYO-ROP study, which used retinal cryocoagulation to treat ROP...
May 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29789774/pilot-study-of-dose-response-effects-of-exercise-on-change-in-c-reactive-protein-cortisol-and-health-related-quality-of-life-among-cancer-survivors
#18
Jeanette M Ricci, Victoria Flores, Isabela Kuroyama, Arash Asher, Heather P Tarleton
Fatigue, stress, and depression contribute to poor health-related quality of life (HRQoL) among cancer survivors. This study examined the effects of combined aerobic and resistance training (CART) on HRQoL and biomarkers of stress. Cancer survivors ( n  = 76, 91% female, 39% breast cancer, 32% gynecologic cancer) were enrolled in CART for three 60-min sessions, weekly, for 26 weeks. Participants completed the National Institutes of Health's Patient Reported Outcomes Measurement Information System (NIH PROMIS) fatigue assessment and the SF-36...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#19
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789356/risk-adapted-treatment-of-acute-promyelocytic-leukemia-results-from-international-consortium-for-childhood-apl
#20
Anna Maria Testi, Andrea Pession, Daniela Diverio, David Grimwade, Brenda Gibson, Amilcar Cardoso de Azevedo, Lorena Moran, Guy Leverger, Sarah Elitzur, Henrik Hasle, Jutte van der Werff Ten Bosch, Owen Smith, Marisa De Rosa, Alfonso Piciocchi, Francesco Lo Coco, Robin Foà, Franco Locatelli, Gertjan J L Kaspers
Pediatric acute promyelocytic leukemia (APL), a rare childhood neoplasm, can be cured with all-trans retinoic acid (ATRA) and anthracycline. However, most published trials to date have employed high cumulative doses of anthracyclines. Here, we report the outcome of patients with newly diagnosed APL enrolled into the International Consortium for Childhood APL (ICC-APL-01) trial, which reduced anthracycline exposure but extended that of ATRA. The study recruited 258 children/adolescents with molecularly/cytogenetically-proven APL...
May 22, 2018: Blood
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