Naomi Dicks, Karina Gutierrez, Luke Currin, Mariana P de Macedo, Werner G Glanzner, Rafael G Mondadori, Marek Michalak, Luis B Agellon, Vilceu Bordignon
Conditions of impaired energy and nutrient homeostasis, such as diabetes and obesity, are associated with infertility. Hyperglycemia increases endoplasmic reticulum stress as well as oxidative stress and reduces embryo development and quality. Oxidative stress also causes deoxyribonucleic acid damage, which impairs embryo quality and development. The natural bile acid tauroursodeoxycholic acid reduces endoplasmic reticulum stress and rescues developmentally incompetent late-cleaving embryos, as well as embryos subjected to nuclear stress, suggesting the endoplasmic reticulum stress response, or unfolded protein response, and the genome damage response are linked...
July 2, 2021: Biology of Reproduction