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https://www.readbyqxmd.com/read/29221664/mechanisms-of-damage-to-the-gastrointestinal-tract-from-non-steroidal-anti-inflammatory-drugs
#1
REVIEW
Ingvar Bjarnason, Carmelo Scarpignato, Erik Holmgren, Michael Olszewski, Kim D Rainsford, Angel Lanas
Non-steroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract, causing widespread morbidity and mortality. Although mechanisms of damage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or COX1) and PTGS1 (COX2), other factors are involved. We review mechanisms of gastrointestinal damage induction by NSAIDs, via COX-mediated and COX-independent processes. NSAIDs interact with phospholipids and uncouple mitochondrial oxidative phosphorylation, which initiates biochemical changes that impair function of the gastrointestinal barrier...
December 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29216527/laparoscopic-management-of-a-drain-site-evisceration-of-the-vermiform-appendix-a-case-report
#2
Anisse Tidjane, Benali Tabeti, Nabil Boudjenan Serradj, Salim Bensafir, Nacim Ikhlef, Noureddine Benmaarouf
INTRODUCTION: Peritoneal cavity drainage is not riskless and several publications reported drain induced complications. However, till this day, abdominal drainage is still a subject of divergence between necessity and usual operative practice. We describe in this publication an exceptional complication of drainage, which is the drain site evisceration of the appendix. CASE PRESENTATION: We report the case of a 47-years-old patient, initially operated for perforated ulcer peritonitis, in whom an evisceration occured 48h after the removal of an intraperitoneal drain placed in the Douglas pouch, the physical examination predicated the presence of a herniated omentum fringe, as a precaution a laparoscopic exploration was performed and revealed that the eviscerated organ was the vermiform appendix, then a two trocars appendectomy was performed and the orifice of the evisceration was safely closed...
November 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29215393/therapeutic-effects-of-lamellar-keratoplasty-on-terrien-marginal-degeneration
#3
Lin Li, Hualei Zhai, Lixin Xie, Jun Cheng, Weiwei Liu
PURPOSE: To evaluate the therapeutic effects of lamellar keratoplasty (LK) on Terrien marginal degeneration (TMD). METHODS: Retrospective interventional case series. Medical records of 63 patients (71 eyes) who received LK for TMD at Qingdao Eye Hospital, Shandong Eye Institute from December 1995 to March 2014 were reviewed. A total of 56 eyes were treated with partial LK and 15 eyes with total LK. Complications, visual acuity recovery, and graft status were evaluated...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29207867/updated-treatment-strategies-for-intestinal-beh%C3%A3-et-s-disease
#4
Yong Eun Park, Jae Hee Cheon
Behçet's disease (BD) is a chronic, idiopathic, relapsing immune-mediated disease involving multiple organs, and is characterized by recurrent oral and genital ulcers, ocular disease, gastrointestinal ulcers, vascular diseases, and skin lesions. In particular, gastrointestinal involvement in BD is followed by severe complications, including massive bleeding, bowel perforation, and fistula, which can lead to significant morbidity and mortality. However, the management of intestinal BD has not yet been properly established...
December 8, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29207760/epituberculosis-revisited-case-report-and-review
#5
Lavina Vishnu Mirchandani, Sindhu S Kamath, Jayalakshami Thelapurath Kutty, Aparna Iyer
Primary pulmonary tuberculosis can involve regional lymph nodes which may resolve spontaneously or on treatment; or they may enlarge causing extrinsic bronchial compression; or cause endobronchial inflammation and ulceration; or a node may erode through the bronchial wall with extrusion of caseous materials into the bronchial tree, causing focal or lobar pneumonia. This erosion is seen radiologically as hilar lymphadenopathy, with atelectasis and consolidation and described as "epituberculosis". It is more common in infants than older children...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29201803/massive-lower-gastrointestinal-bleed-caused-by-typhoid-ulcer-conservative-management
#6
Apoorv Goel, Roli Bansal
Typhoid fever is caused by gram-negative organism Salmonella typhi. The usual presentation is high-grade fever, but complications like gastrointestinal (GI) hemorrhage and perforation are also seen frequently. With the advent of antibiotics, these complications are rarely seen now. We present a case of a young female who was admitted with a diagnosis of typhoid fever presented with a massive GI bleed from ulcers in the terminal ileum and was managed conservatively without endotherapy and surgery. How to cite this article: Goel A, Bansal R...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29197190/percutaneous-treatment-with-radiofrequency-ablation-of-varicose-veins-recurring-after-vein-stripping-surgery-a-preliminary-study
#7
Giovanni Turtulici, Ermenegildo Furino, Giorgia Dedone, Riccardo Sartoris, Jeries Zawaideh, Aldo Fischetti, Enzo Silvestri, Gennaro Quarto
AIM: The aim of our study was to evaluate the efficacy of a new treatment of recurrent varicose vein after stripping of the great saphenous vein with rigid radiofrequency needles. MATERIAL OF STUDY: 37 patients enrolled (11 males and 26 females). 10 patients had recurrent varicose veins for the presence of residual reflux in the Saphenous-Femoral Junction (SFJ) stump, whilst 21 patients for the presence of a single or multiple re-chanalized and refluxing perforator veins, and 6 had mixed rechanalization due to perforator veins and refluxing saphenous stump...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29181171/subserous-invasion-of-vegf-c-producing-cancer-cells-is-a-possible-risk-factor-for-ileal-ulceration-in-the-non-metastatic-mucosal-layer-during-bevacizumab-combined-chemotherapy-for-recurrent-ovarian-cancer-a-case-report
#8
Takeo Matsumoto, Yasunari Mizumoto, Kyohei Nakade, Takeshi Obata, Ayumi Matsuoka, Subaru Myojo, Masanori Ono, Mitsuhiro Nakamura, Hiroshi Fujiwara
A 65-year-old woman received chemotherapy using taxane and carboplatin prior and following optimal debulking surgery for ovarian cancer stage IV. Five months later, intra-abdominal recurrence was diagnosed, and second-line chemotherapy using nogitecan and bevacizumab was administered. After five courses, the patient presented with a symptom of subileus and subsequent intestinal perforation occurred. An emergent surgery revealed two perforation sites and longitudinally extended ulcerative lesions in the ileum...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29180201/laparoscopic-repair-of-perforated-peptic-ulcer-simple-closure-versus-omentopexy
#9
Being-Chuan Lin, Chien-Hung Liao, Shang-Yu Wang, Tsann-Long Hwang
BACKGROUND: This report presents our experience with laparoscopic repair performed in 118 consecutive patients diagnosed with a perforated peptic ulcer (PPU). We compared the surgical outcome of simple closure with modified Cellan-Jones omentopexy and report the safety and benefit of simple closure. METHODS: From January 2010 to December 2014, 118 patients with PPU underwent laparoscopic repair with simple closure (n = 27) or omentopexy (n = 91). Charts were retrospectively reviewed for demographic characteristics and outcome...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29179680/stercoral-colitis-complicated-with-ischemic-colitis-a-double-edge-sword
#10
Maliha Naseer, Jenil Gandhi, Noor Chams, Zain Kulairi
BACKGROUND: Stercoral colitis is a rare inflammatory process involving the colonic wall secondary to fecal impaction with high morbidity and mortality; especially if complicated with ischemic colitis, stercoral ulcer formation and subsequent perforation. There are several case reports published on abdominal perforation resulting from stercoral colitis. However, stercoral colitis complicated by ischemic colitis is rare. The purpose of this case report is to describe the potential challenges in the diagnosis and management of stercoral colitis with ischemic colitis...
November 28, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29178963/chloral-hydrate-enteral-infusion-for-sedation-in-ventilated-children-the-chosen-pilot-study
#11
Ari R Joffe, Jessica Hogan, Cathy Sheppard, Gerda Tawfik, Jonathan P Duff, Gonzalo Garcia Guerra
BACKGROUND: We aimed to test a novel method of delivery of chloral hydrate (CH) sedation in ventilated critically ill young children. METHODS: Children < 12 years old, within 72 hours of admission, who were ventilated, receiving enteral tube-feeds, with intermittent CH ordered were enrolled after signed consent. Patients received a CH loading-dose of 10 mg/kg enterally, then a syringe-pump enteral infusion at 5 mg/kg/hour, increasing to a maximum of 9 mg/kg/hour...
November 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29165521/-gastrointestinal-tuberculosis-as-a-cause-of-massive-gastrointestinal-bleeding-in-a-patient-with-hiv-infection
#12
Omayra Chincha, Jaime Cáceres, Carlos Seas
Gastrointestinal tuberculosis is a rare and fatal complication in patients with HIV infection. It occurs in 3%-16% of extra pulmonary forms. The main location in 90% of cases is the ileocecal valve and colon. The most unusual presentation of gastrointestinal tuberculosis is massive bleeding with the presence of one or multiple ulcers in the colon. The diagnosis can be confirmed by biopsy and by culture of intestinal tissue. Surgical resection is the treatment of choice. We report a case of a HIV-infected patient, who did not receive antiretrovirals, and who developed disseminated tuberculosis with intestinal perforation, presenting a fatal massive intestinal bleeding...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29155448/influence-of-national-centralization-of-oesophagogastric-cancer-on-management-and-clinical-outcome-from-emergency-upper-gastrointestinal-conditions
#13
S R Markar, H Mackenzie, T Wiggins, A Askari, A Karthikesalingam, O Faiz, S M Griffin, J D Birkmeyer, G B Hanna
BACKGROUND: In England in 2001 oesophagogastric cancer surgery was centralized. The aim of this study was to evaluate whether centralization of oesophagogastric cancer to high-volume centres has had an effect on mortality from different emergency upper gastrointestinal conditions. METHODS: The Hospital Episode Statistics database was used to identify patients admitted to hospitals in England (1997-2012). The influence of oesophagogastric high-volume cancer centre status (20 or more resections per year) on 30- and 90-day mortality from oesophageal perforation, paraoesophageal hernia and perforated peptic ulcer was analysed...
November 20, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29149927/gastrointestinal-involvement-in-beh%C3%A3-et-disease
#14
REVIEW
Ibrahim Hatemi, Gulen Hatemi, Aykut Ferhat Çelik
Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. This article highlights the current knowledge on the epidemiology, clinical findings, diagnosis, and management of GI involvement of BD, with emphasis on recent findings.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29146893/von-hippel-lindau-disease-with-multi-organ-involvement-a-case-report-and-8-year-clinical-course-with-follow-up
#15
Ali Yaghobi Joybari, Payam Azadeh
BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. A nucleotide scan showed left adrenal involvement...
November 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29142512/non-steroidal-anti-inflammatory-drug-induced-enteropathy
#16
REVIEW
Sung Jae Shin, Choong-Kyun Noh, Sun Gyo Lim, Kee Myung Lee, Kwang Jae Lee
Non-steroidal anti-inflammatory drugs (NSAIDs) are well known to be associated with serious upper gastrointestinal complications, such as peptic ulcer, bleeding, perforation, and obstruction. Recently, attention has been mainly focused on the small bowel injuries caused by NSAIDs, and new endoscopic techniques such as capsule endoscopy and double balloon endoscopy can help in detecting such injuries. This article reviewed the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of small bowel injuries caused by NSAIDs...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29140941/phenotype-and-management-of-infantile-onset-inflammatory-bowel-disease-experience-from-a-tertiary-care-center-in-china
#17
Ziqing Ye, Ying Zhou, Ying Huang, Yuhuan Wang, Junping Lu, Zifei Tang, Shijian Miao, Kuiran Dong, Zhinong Jiang
BACKGROUND: Infantile-onset inflammatory bowel disease (IBD) comprises rare and clinically severe disorders. We examined the phenotypes and genetic causes of patients with infantile-onset IBD from a tertiary medical center. METHODS: We enrolled 38 patients with infantile-onset IBD and applied standardized treatment with medical, surgical, and supportive care. Targeted sequencing and whole-exome sequencing were performed. Clinical data were retrieved from medical records...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29134185/infiltrative-intraocular-conjunctival-squamous-cell-carcinoma-after-local-resection-and-brachytherapy-clinical-and-pathological-findings
#18
Magnolia Trinidad Cano-Suárez, María Antonia Saornil-Álvarez, Ciro García-Álvarez, Francisco López-Lara, Jesús María Frutos-Baraja, Elena García-Lagarto
A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctival squamous cell carcinoma (CSCC). Excisional biopsy showed a well-differentiated CSCC with positive margins and the patient underwent adjuvant brachytherapy. Six weeks later, examination of the anterior segment revealed cells in the anterior chamber and a neurotrophic corneal ulcer with corneal perforation. Considering the high suspicion of intraocular invasion of CSCC, the left eye was enucleated...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29129978/a-case-of-peripheral-ulcerative-keratitis-associated-with-autoimmune-hepatitis
#19
Hamoon Eshraghi, Aria Mahtabfar, Mohammad H Dastjerdi
Purpose: To describe a case of peripheral ulcerative keratitis in the setting of autoimmune hepatitis and possible overlap syndrome with primary sclerosing cholangitis. Case Report: A 48-year-old African American female with autoimmune hepatitis with possible overlap syndrome with primary sclerosing cholangitis presented with tearing, irritation, and injection of the left eye that was determined to be peripheral ulcerative keratitis. The patient was treated with topical and systemic steroids, immunosuppressant drugs (azathioprine and mycophenolate mofetil), a biologic (rituximab), and surgery (conjunctival resection), and the peripheral ulcerative keratitis epithelialized but ultimately led to corneal perforation...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29122603/the-role-of-colorectal-endoscopic-submucosal-dissection-in-patients-with-ulcerative-colitis
#20
Satoshi Kinoshita, Toshio Uraoka, Toshihiro Nishizawa, Makoto Naganuma, Yasushi Iwao, Yasutoshi Ochiai, Ai Fujimoto, Osamu Goto, Masayuki Shimoda, Haruhiko Ogata, Takanori Kanai, Naohisa Yahagi
BACKGROUND AND AIM: Patients with ulcerative colitis have an increased risk of colorectal dysplasia. Endoscopic submucosal dissection (ESD) for the neoplastic lesions in ulcerative colitis remains controversial. The aim of this study was to clarify the role of ESD in treatment strategy for ulcerative colitis. METHODS: We retrospectively investigated 25 patients with ulcerative colitis in clinical remission who underwent colorectal ESD at two referral centers. We analyzed short-term and long-term outcomes...
November 6, 2017: Gastrointestinal Endoscopy
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